<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHD9</accession>
    <name>A0A139SHD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NGN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713253.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08115"/>
    <dbReference type="EnsemblBacteria" id="KXU33992">
        <property type="protein sequence ID" value="KXU33992"/>
        <property type="gene ID" value="AXK12_08115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="22484" checksum="A5A8363EF2D1B451" modified="2016-05-11" version="1">MALKGNSEGPAAPACNGEPPVQERGGEDNAPDKNSLPLWWVCHCKPRCEKKVAALMQAHGFEHYLPLVRSERRYGARIKVFTKPLFPGYVFAKIPPEKKPLIYQQDLLARAFEVEDVPRLLAQLDDIRALLASGLDFTLKPLLTKGRRVRIISGPLKGVEGFVEAPESSGKHHGSGGGNTSGVLLSIDVLQQGLLVPVPAADLKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHE9</accession>
    <name>A0A139SHE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_08175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713271.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34002">
        <property type="protein sequence ID" value="KXU34002"/>
        <property type="gene ID" value="AXK12_08175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010100">
        <property type="entry name" value="TonB-dep_Cu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01778">
        <property type="entry name" value="TonB-copper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299196" evidence="6">
        <location>
            <begin position="20"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="203"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="673" mass="72085" checksum="0657066EF79A03A8" modified="2016-05-11" version="1">MKSFSFVFLATALTAFAQAESLSASDAVSVLSPLVVTSVRAQSKPLTVISSTQTPVQPIPAQDGADTLKAIPGFSVGRKGGTGGEVTLRGQAGSRLDLLLDGQSVLGGCPNRMDPPTAYIFPASFDRVRVLKGPQTVLYGPGNSAGVVLFERELRRYVQRTAQADASATLGSFGRRDAWASARAGSALGYGEVSLNHTRAADYEDGDGARVHSQYERTSVNAALGWTPDAQTLVELSGTWSEGEAAYGHSMMDATQLDRESLALRVERTELSSKVARVEAQLAYNHADHIMDDFRLRVPGMMPMGESRPDHRVWSGRVLGEFAASEALELRLGGDFREGRHRSKDSGAWVADAKIGSTGVFAEAEMGLGDRGRVLAGARLDRWEAQDFRQSLASGMMGMGGSVPNPTANAKRRTTLAAGFVRYEHGSQEQEGLTSYAGLGYTERAPDYWELVRHESLGTRSAFGTRPEKTAQLDIGLNYARGPFTAFVAAFANRVDDFILLQNGVVKGMRTVTAVRNVDAESWGGEAGLGYTLAEQWHVDTSLAYVRGRNRSDAAALAQQPPLEGRLSVSYAAPRWSVGALARAVAAQNRVAVGQGTIAGQDLGRTPGFGVLSLNAGWRVTERATLTAGVDNVFDKTYAEHLSRAGAAVNGYPTTARINEPGRTLWTTLRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI4</accession>
    <name>A0A139SHI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713280.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08195"/>
    <dbReference type="EnsemblBacteria" id="KXU34006">
        <property type="protein sequence ID" value="KXU34006"/>
        <property type="gene ID" value="AXK12_08195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="522" mass="57793" checksum="AF4E24E8EAB00BF9" modified="2016-05-11" version="1">MAQNDNNGGTLGFEAELFKAADKLRGNMEPSDYKHVALGLIFLKYISDAFEARHAELLAEDAAAAEDKDEYLADNIFWVPKQARWSHLQANAKQSSIGTLIDEAMRAIEKDNESLKGVLPKDYARPALNKVMLGELIDLISGIALNEGNDTSKDVLGRVYEYFLGQFAGAEGKRGGEFYTPRSVVRTLVDMLEPYQGRVYDPCCGSGGMFVQSEKFVSEHGGRIGDIAIYGQESNYTTWRLAKMNLAVRGIDSDIRWNNEGSFHKDELRELKADFILANPPFNISDWGGERLREDVRWKFGVPPVGNANYAWLQHIFHHLAPHGFAGVVLANGSMSSQQSGEGDIRKAMLEAANGAGVVDCMVALPGQLFYSTQIPACLWILAKDRSNGLVKESKLRDRRGEVLFIDARKMGVLVDRTRRELTDSEIRKIADTYHAWRGEAEAGEYSDIPGFCKSATVDEIRKHGHVLTPGRYVGAAAVEDDSEAFEDKMQRLTAQLGEQMKRGAELDAVIRKNLGALGHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI6</accession>
    <name>A0A139SHI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713350.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08040"/>
    <dbReference type="EnsemblBacteria" id="KXU34038">
        <property type="protein sequence ID" value="KXU34038"/>
        <property type="gene ID" value="AXK12_08040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="292" mass="32090" checksum="D0C561534DDDD465" modified="2016-05-11" version="1">MTETVALFHRDLGENRAGAVAEGEGERPPLILLHGLLGSSRNWQAVGRDLAQSAAAWPGQEAASECAAGSEARVRVFALDARNHGQSPHSDSMDHASMAEDLRAWLDSQKISEPVDLLGHSMGGRTAMAFACRYPERVRRLIVVDTAPRAYEWAGGRPEFAAMNALDLRTLSSRAEAERVMEPRVPDWGMRKFLTTNLERDEEGQWRWSINLAGITAALPALEASPLAAGECFEGEAHFIVCGRSPYVRAEDHALIREHFPAAQITVLPDSGHNPHMEAREAFLRTILRIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM3</accession>
    <name>A0A139SHM3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713237.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08070"/>
    <dbReference type="EnsemblBacteria" id="KXU33984">
        <property type="protein sequence ID" value="KXU33984"/>
        <property type="gene ID" value="AXK12_08070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="528" mass="57214" checksum="EDF7E4E672F56630" modified="2016-05-11" version="1">MSACARVLSKSVFAVKAELGPPQFRASMSARGLLSFDAPPFVFHTPMLPRIFRTRFPFFAAFSFSLVAMPGLGFVRAAEVRILAAAEVDALFTHEADTFVGVHAEAPGSAGLHELLVAREFTLGEALGVVSQSSLEVLISREAVTQAIEAQRQTRSGLLPRVTLDAAQRRSQVATLGGAPQPSPSNRFDGALNARLDLVNPVNLARYSAARAAVTVAQLGEAGTRQAILAAVAETYFAHLRNLERTRVLEDNIARAQRLLELATHQLNAGVATQIDVTRAEALVVVAEQALIQQGTVVHSSELALKRLLAFDNMHAPLALAPFELPRALPSRRRDEGEVFAHRAELRAARALLEQNLIEIRAARSNRLPSLALVGNYGYASAVAFNGDERKAWTTSAAVSVPIFDGAQTRAMTRQARSRHRAQTLRVRSLENQVSAEHQLAMQDAASRLAQIGVAETQLALAREELDLAEKRFEQGVADNREIIEAQGRLATAEDNLVEAIFLYNVSRVELARAQGEVLEILSGGNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHX3</accession>
    <name>A0A139SHX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713158.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07870"/>
    <dbReference type="EnsemblBacteria" id="KXU34182">
        <property type="protein sequence ID" value="KXU34182"/>
        <property type="gene ID" value="AXK12_07870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="29859" checksum="33331DB04B2BE034" modified="2016-05-11" version="1">MHKLNYYLKLWLASVRYSVTRTLMFRADFLLWSTVELFWMGINILLVSVIYAHTDSIAGWSKYEMLLLLGTSMLVQRLLIGFFWANIHELGDNIRTGKFDFFLAQPGNLMFMASTRKLDLDSLANSVVAIALVAYSARELGLSPSLLDLATYAFLVGCGLVIHYSFMLTMVSLSFWITNAQGLEGSYFTLFSFSRIPREAFRGVTQLVFVWTLPVVIVSNAPAQTILYGFNPQLCLWLAGAAAFWFALTVIVFHCGLKRYSSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI14</accession>
    <name>A0A139SI14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713118.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34161">
        <property type="protein sequence ID" value="KXU34161"/>
        <property type="gene ID" value="AXK12_07725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="465" mass="51915" checksum="94DE4CD117CF6544" modified="2016-05-11" version="1">MNLSRSLSDRFLSPGGLLILSFAVVSSILVALLPSSEPEGIEYWVFVQEHASAYEARIERWNRENPDRVFAMKLLHAGALERRMLSGFLTGTPTADLMEVTVGMSPKAFLGPIDRVGFLDLTERLHEEGLYEQFNKPSLSPHTSRGHIFGLPHDVHPAVLAYRADIVEAAGIDVSEIETWEDYFRVMRPLMVDLDGDGRPDRYSLNFSEFDQDMIIGFLLQNDGVIFDEQEQPAFANERNARSLATMVTWVTGPERASTPVPIHSPSGLKQLMDGLVIGTPIGDIQLGMWKFNTPRLGGMMKVMPLPAWERGGRRTTVLGGGTMIGINKRSPNIEAAWEMAKELYMSREIAEATYRTNMIISPVMAFWDEAFYHEPDPFFCGQSPGSFLVAAAPDVPTRPSSPYTPTAYSRIGVAMITLRAYADKHGIYDAEGLYPEALRLLQEEEESLNKLISRNLLYSESSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI81</accession>
    <name>A0A139SI81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712963.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07320"/>
    <dbReference type="EnsemblBacteria" id="KXU34282">
        <property type="protein sequence ID" value="KXU34282"/>
        <property type="gene ID" value="AXK12_07320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="28606" checksum="589F749AE8FEE0C2" modified="2016-05-11" version="1">MRNKLRTIGYPCATGALVIALWYGLWHRLSPETRFLLPLPHEVLAALRDNFALLTRAILNTTQAALLGFGLAILASVACAVVLSLSRLIRLSLYPYLMILQMTPIIIMVPILILWVGPGLPSVVMVTFLMCFFPLVVNTTQGLISADRGLVDLFKLYRATEAQTLWRLRLPGALPYFFTGLRIAAVLAPIGALVGDYTAGSTVRGAGGLGFQAVLFSSQGKYAALFATAGLTCLLGFLFVCTVLGLSWLCLHKWHSSYHQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIA1</accession>
    <name>A0A139SIA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713017.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07475"/>
    <dbReference type="EnsemblBacteria" id="KXU34308">
        <property type="protein sequence ID" value="KXU34308"/>
        <property type="gene ID" value="AXK12_07475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="227" mass="25469" checksum="9E3A3B60C4321ED6" modified="2016-05-11" version="1">MIDAVKHLIDFILHIDVHLKEIVEQYGTATYAFLAMIVFAETGLVVTPFLPGDSLLFAAGALASPVESQLNVHLLALTLFGCAVAGDSLNYWIGSRIGPAVFKREDSIFLRKKHLERAHAFFERYGGRAIILARFVPIVRTFVPFVAGVGTMSYRHFMAYNVLGGFAWVYFFTYAGFFFGELPFIQSNFKLVILAIIVLSVIPMVVEGLQAWRRSRREQRAALSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB3</accession>
    <name>A0A139SIB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713031.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07515"/>
    <dbReference type="EnsemblBacteria" id="KXU34315">
        <property type="protein sequence ID" value="KXU34315"/>
        <property type="gene ID" value="AXK12_07515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="350" mass="38975" checksum="1EF75D40214F683F" modified="2016-05-11" version="1">MNKGTTRLGTIWYDCTKSAKATHRSGLQRVAHKLLEELGEAATPTQGLEWVPRARAEDWFLTAEVFGPSERPEFAEILANRPCRMAAIFYDAIPLKQPHITWPASVARHPAYMKMLASFDLVLAISEASRRELLDYWAWMGLSRVPRVEAIQLGSNFAASPRALPKPERAEGPALLLCVGIIEPRKNQRFLLDVCAPLWAEGAEFELHVVGRVNPHFGKPIIEQMKRVARGRSRVRYHKHLSDEGLAGLYERATVNVFPTIAEGCGLPVLESLWRGVPCLCSDIPAIRENATDGGVLLLPPNDGEAWARALREVTQSGSVLWERLRSEVAARPLPTWADTAKQALGYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC2</accession>
    <name>A0A139SIC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712996.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07415"/>
    <dbReference type="EnsemblBacteria" id="KXU34299">
        <property type="protein sequence ID" value="KXU34299"/>
        <property type="gene ID" value="AXK12_07415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="767" mass="84346" checksum="553A85D24B378817" modified="2016-05-11" version="1">MKPSLIAAAFGLCSCVFRLTPELVAQSRPYTADQAQQADDEMVVLPTFTIESDTVDRYRAADALSSARVRTQLIETPSSISVIPRVFLEDVVPVRLYEAAKYIAGVQDARGNTFQDRVTIRGFESAGRLVNNFSDTGAHNIDESLIERVEISKGPNAILSPGGNPGGTINIVTKAPEFTAKHSITALVGQYDAQKVSIDTTAPLPDSDRFAYRVIAAYQDTRRYVSSEAKLRTKVIAPQFTWKISPTSELITRYDYLETITFREQFMIIDPEAVGTKAPAPAPGFNWRGTNGAPGWSNLAYQKHSFSLEFNTSFNQYLTMRLAGRFQRARETSEQAAIVVPGLADRYNPYTGIQTPNQTWGLVDPNLDHDEVLNPYVPTDSPYYDPTNIEVRATRNLGSYTNTYSLQNDWVLSVEVPYAKLQTVAGFAWANDKGVGLAGEGALAPLNLFDLASYDPNPTWGSALIADNESKATNWQLYLNQRVTFWEDRIALTGGVLRYDTDGKGRDKLVGGPWNGLAEAKDLFLGSVLVRITPSASVYYSHSTNATPTVVDSVPTWREGKQQEWGAKMEFFNRRLGVNIAYFEIRQTNVVTGNPEYYAGDLTQPPEILTDYGNHGTEFEVTGALTRNLSVVGSVTDLKMRDPRGRRVRSIADRLAGLMLNYHFDEGALKGLSLKLGGNYVGGRAGDLPSGEFTQLGVVRQTSFFVPSQTLLNAGASYEWGGFGVRLIVNNLADKKNYFSGAGGRFSGTGLFTATGRNIRGAFTVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN5</accession>
    <name>A0A139SIN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712936.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00555"/>
    <dbReference type="EnsemblBacteria" id="KXU34435">
        <property type="protein sequence ID" value="KXU34435"/>
        <property type="gene ID" value="AXK12_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="281" mass="30605" checksum="9E8DCF512FEE2EFE" modified="2016-05-11" version="1">MNPHPSKPADIGELKRRATQLRRHMLTMAHGQGQGYIGQGLGMADVLAALYFHELRYDPANVNWPERDRFLLSTGHYSIGLWAALAEAGVLPLEELPTYGADGSRLEMSTLDTTPGVEMIGGALGHGLGQGVGQALGLRLDGSTARVFVELSDGEMQEGSTWEAAMSASHFKLDHLVALIDCNGIQADGPMVLDMEPIAEKWAAFGWETQEIDGNDISAVVTALERARARQGKPHAIVLRTLPGKGVRRIETSEKAHFFRVNTDQWDDIIAEFEHSLEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP7</accession>
    <name>A0A139SIP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712903.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34419">
        <property type="protein sequence ID" value="KXU34419"/>
        <property type="gene ID" value="AXK12_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="105" mass="11854" checksum="FD80D4E8E1A83EDE" modified="2016-05-11" version="1">MTTTIPNSPLPGLRLSTDNPNHHLWNNHGTWFLHYTTHPTPFTKERIRRSLGTKSLETARERRDVFFAQLAREVAIRRGGCSTQNFGNVAHCAIALHHAAEEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIR1</accession>
    <name>A0A139SIR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712920.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34426">
        <property type="protein sequence ID" value="KXU34426"/>
        <property type="gene ID" value="AXK12_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299221" evidence="1">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="200" mass="22906" checksum="41E487EFBF15140D" modified="2016-05-11" version="1">MKTPLTRPTRFLFALLACAAAFLLTAREGIAKSNTRYIRIDPVEHSGFDIDDLKKAFAAVSATLDKIADERFGPQSGNYQRLRRSVPVKVQVVDLSNHTPYEFEKVVLRGAQLQEIRDKKGSLWTRYTASDPTRLRWAKTDYKLMLLAHVGLDREASTEDDPRFYYQWRLSELFGDYKVVATGREPLRARDPATLRLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIV3</accession>
    <name>A0A139SIV3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dinB</name>
        <name evidence="14" type="ORF">AXK12_00485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712916.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00485"/>
    <dbReference type="EnsemblBacteria" id="KXU34424">
        <property type="protein sequence ID" value="KXU34424"/>
        <property type="gene ID" value="AXK12_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="43196" checksum="2800A36A8136B247" modified="2016-05-11" version="1">MPRPPLPTIVHLDADAFFVSCELARRPELRGKRCAVGGGPQRGIISSASYEARAVGVYTPMPTARALRVCPDLILLPHDNEHYAKTSQAMFDLCETVTPLVQRNSIDEGYLDLGPCACASVAAVEAKVRGLVARIWEELQIPVSIGIGTSLLVSQIASKLRKPRGFVTVPVGEEAAFLAPLPIEQLPGIGKKTAEEVKARGLRTIGDVVRKTDSALAGILGRDWRQVAAWARGIDTRAVETERAAPKSYSQQETFLEDRAFGDFEDIERGLKRMLDELLVKLRADGKRARTLTVKVRYPDFTNSSHAQSLPEPSDLERPFYPLVGDLLRAAWTRRRQPLRLVSVRLSGLTEGPAQLDLFTSANEAKHRHLAAVVDRLNANGKKPRVYHGYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIX8</accession>
    <name>A0A139SIX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34525">
        <property type="protein sequence ID" value="KXU34525"/>
        <property type="gene ID" value="AXK12_07165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="19248" checksum="E26DE457D95AA607" modified="2016-05-11" version="1">MGKSPSSENSPRWGAFLRKARLRIGRGVIPLRVVVFSCARIFILSVMTLAWGVGFFHSSLCAADWLPDHEHHHPAYHDPANPHAHEHTVGDGGDQEPLWAAQPTSHASLLLAVLTALLLAPLFLSPRWTLSALLRVARPKVAPRWRINGSHTRDPIWHFVRRCAPDIAAPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJJ2</accession>
    <name>A0A139SJJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712772.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07055"/>
    <dbReference type="EnsemblBacteria" id="KXU34693">
        <property type="protein sequence ID" value="KXU34693"/>
        <property type="gene ID" value="AXK12_07055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="37186" checksum="F8DA1F593117EFB4" modified="2016-05-11" version="1">MPLPSRETFPLITVGVPTYNRADVLRQMLECLVRQDYPPERLELLVIDNNSPDNTREIVAEFEKDAAEARPALGQFSHCVSYVHEPKQGLGHARNRAIAEARGDIIVLPDDDILAEPDWLRTLCAPLIAEWREGGHSIGCVAGEVLPIFPDGLPDWVRDWHGPQGFRSAEEGAGPLPKTAYPMGANFAFPRWAFERLGPFSTELDRKGASFFGGGDREMLRRIHEADYAVWFVPAARVLHQMPASRTTFRYAARHAFDSARSRVVERARLGRKSSYLVSRFFGNALKALGFAFVALGCALLFQRGAAKRALVRAWRCCGYLYQIARSLFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR2</accession>
    <name>A0A139SJR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712712.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34809">
        <property type="protein sequence ID" value="KXU34809"/>
        <property type="gene ID" value="AXK12_06895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="96" mass="10966" checksum="89419F996E159432" modified="2016-05-11" version="1">MVISASLYCILIGLFFLGLWLYYDRRDHKRFERKRRRRTYHCIRCNHLYQFPAGDWSAASASAEGAANESAWGAKSGAPSTAKCPHCGHENTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY0</accession>
    <name>A0A139SJY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712525.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06395"/>
    <dbReference type="EnsemblBacteria" id="KXU34865">
        <property type="protein sequence ID" value="KXU34865"/>
        <property type="gene ID" value="AXK12_06395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="293" mass="32172" checksum="6977C5EBAD63ED67" modified="2016-05-11" version="1">MELRHLRYFVAVAEALNFRRAAERLHVAQPALSKQIKQLEEGIGVQLLSRNTGGVSLTDAGAVLLDEARDILERVEMAASAAADAAIGKSGRLNVGNLGLLTASFLPTVLSEFRARYPQVDVNLIEVGMVDQLSALQAGQVHVGFMVGRTVSLPVGFEWVEVLSARPAVIMSREHPLASRPSIALSELAMEPLLTVAEPGKQTRHQQYLNETFAVRGIRHRPPRRVSSFESLIAMVESGLGVSILLPLSRGFDNVVFRPLKDKEDDLTAHLFAVWRKGTESRILKNFLKVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY9</accession>
    <name>A0A139SJY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_06430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712538.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06430"/>
    <dbReference type="EnsemblBacteria" id="KXU34871">
        <property type="protein sequence ID" value="KXU34871"/>
        <property type="gene ID" value="AXK12_06430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="43"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="278" mass="30144" checksum="AA47C7A0E5BFD08C" modified="2016-05-11" version="1">MAKRRQLRSFDLKQLSGGAGSASSSTRVSLSASRSGGAVEWLIGVDEAGRGALAGPVVAAAVRVGRDFLEGRWALANASRVSDSKQLSPAEREALCFDFEVLAGQGQLRLHWGLADVDEIAQFNILGATKLAMRRALEGLYPPSAFAPEQPPEPDLFSEPETLAAYQPPVSARILIDGLALRHFPYPHTGVVKGDARSLCIAMASIIAKVKRDRLMTELAAEFPGYGFEQHKGYGTGQHREALLARGRTPQHREVFLRKLFAKRADPAQVDFWVSPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ2</accession>
    <name>A0A139SJZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712507.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34856">
        <property type="protein sequence ID" value="KXU34856"/>
        <property type="gene ID" value="AXK12_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="592" mass="66894" checksum="9932021A6E4F8615" modified="2016-05-11" version="1">MQIGRVARLLLLVATVCVVWLTIENRWGSNFQLPTRYAYDAHYVLGMMKLAQEGDLGLFSHIYTKSLGAPFVGQLNDFPQTERVIIWVGGQVARVVGLMPAANAMLILSCVLAALSFYLSARLWKINRVPAWVFAVTYAFLPHNSRSIQHLGIIFTGLLPLQFYILWYVSAAQKLSWRSRRFRLTLVVSLLSGLLNIYWIFFFLQLYVLALLFRIIKRSRDFTKALIPFAITCLSAGVFLGSFIIYRISYGDNAMAVVRSYADIEQWALKPIDLFLPKTPPPLPIVSTVLSRYYDGGMIKIGENFGSYIGLFAALGLLALLFKSSQRQISRKSISLPCLAAIWIIAYTAFGGLHSVFSLVFDFYEIRATNRYSTAIATIGLLYFVFISHKLTRKWNPTLRLFFLGVGAVCGLLEQSWSAYRTPSPPPALYEVADYVKADKALVSRLEHGLEPGSMIYILPATDFPEPFWGRGKFKGDFHHYQAMRPFLYSTKLRYSYGSNKGRQGADWQLDVQELAPRGMAATLESYGFAGILLNRKGYEDRGEQVLAELARAGWPMEFEQGVDNEWVFIRLTPEQNPVLPTPTPYALTPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK00</accession>
    <name>A0A139SK00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">AXK12_06515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712568.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06515"/>
    <dbReference type="EnsemblBacteria" id="KXU34885">
        <property type="protein sequence ID" value="KXU34885"/>
        <property type="gene ID" value="AXK12_06515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="226" mass="24469" checksum="74D0738E5A273EFE" modified="2016-05-11" version="1">MLRLVRLLQLASPALPVGAYTYSQGLEWAVESGAVTDEATAARWIGDALSYTLARLEAPLTAALLAAWRTGDDARVSELNADFNASRETMELRAETVQMGWSLLRLLSELDAFAGLPGWRDRLVAVNEPAFPTVWTAAAAAWGIAAEQALTAYLWMWLENQVMAAVKAIPLGQSAGQRLLATLGKRIPGLAAEAASLPEPQWSNFSPGLAITSSLHETQYTRLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK21</accession>
    <name>A0A139SK21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">AXK12_06745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712634.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06745"/>
    <dbReference type="EnsemblBacteria" id="KXU34922">
        <property type="protein sequence ID" value="KXU34922"/>
        <property type="gene ID" value="AXK12_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="157" mass="17766" checksum="2E056B88D34E937E" modified="2016-05-11" version="1">MSRRHRATKRKITPDARYNSPLVAHLVNVVMKDGKKNTAQRIVYGAFEKVSEKLDKGNPVDLLLGAMENTRPRLEVKSRRVGGATYQVPVEISFERQESVALRWLVAAANNRKAMPMRDALAAEIVDAYNNTGVVVKKKDDTHRMAQANRAFAHLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK46</accession>
    <name>A0A139SK46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712503.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06330"/>
    <dbReference type="EnsemblBacteria" id="KXU34854">
        <property type="protein sequence ID" value="KXU34854"/>
        <property type="gene ID" value="AXK12_06330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="136" mass="14508" checksum="7C0B0901F922DFCE" modified="2016-05-11" version="1">MSNSKLYVGNLPFKANEDDLRAHFAQFGDVTDVYVAMDRMSGRPRGFAFVTMGTEEEAKQAAEKLNGTDFDGRQLTVNEARPKEERPAGGGFGGGGRGGFGGGGRGGFGGGRDRGGFGGGGRDRDRGGYDRDRERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK51</accession>
    <name>A0A139SK51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ORF">AXK12_06210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712461.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06210"/>
    <dbReference type="EnsemblBacteria" id="KXU34958">
        <property type="protein sequence ID" value="KXU34958"/>
        <property type="gene ID" value="AXK12_06210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="105"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="374" mass="40311" checksum="E4F934038FF48F2A" modified="2016-05-11" version="1">MPARPRVDLYSLTRAELGEVLAAWGVNPVHAGPAWRALYWDCVRDFAELRAVGCVPPRVCALLEERATLGTLPAVLEGDSSDGFTRKFLLGLHDGERIETVLMRYTGRVTACVSSQVGCAMGCVFCATGQRGYTRHLTAGEIVAQAVYVQRALLGGDACGLPSVTNPASRAKVSVRDASQRLRNIVLMGMGEPLHNYEAVMRAVEILSDGTGLAIAAERITLSTVGVVPGILRLAREQRRVHLAVSLHAANQEERAAIVPTARKWPLAQLMDACRTYSAETGRRIFYEWTLIEGKNDSPEQAREVGRLLAGLPAQVNLIPLNPTKGYAGAATRSEAARAFQRVLIEEFGIPSTVRQRRGIDIAAGCGQLAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK97</accession>
    <name>A0A139SK97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712611.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34910">
        <property type="protein sequence ID" value="KXU34910"/>
        <property type="gene ID" value="AXK12_06665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299306" evidence="2">
        <location>
            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="179" mass="19627" checksum="A315C30439F198C2" modified="2016-05-11" version="1">MNTIFLSVRSRHSSRRRLVTALLAAALLVAVASQVRASEPQKPIADPATQEDSTPRDGLSMRAPLSQFRLPTFNAQGHRSMLIESSEAIVGPNQIELTNLNLTLFDGTAQSAIETILLSPQATALTDEETISGEGPVRIIRDDVEITGIGWRYEHAARKVSIAKNTRIRFQSSLPDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA7</accession>
    <name>A0A139SKA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable potassium transport system protein kup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kup</name>
        <name evidence="12" type="ORF">AXK12_06565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712658.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34930">
        <property type="protein sequence ID" value="KXU34930"/>
        <property type="gene ID" value="AXK12_06565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="645" mass="69870" checksum="8C46974A188D5CD1" modified="2016-05-11" version="1">MPPAASGSHAPPPADPHKHTRAGLALIALGVVFGDIGTSPLYALRQSVALLPAEEVTSGLLGILSLIFWSLVGVVSVKYMGFVTRADNRGEGGIFALFVKSRLDSPDKKKKHQHRLRPHTILILIGACMLCGEGVITPAISVLSATEGLSLVAPETSPLVVPLAIMLLLGIFWFQSKGSEKIGRIYGPIMLLWFTVLGGLGLWQVIREPLVLQALAPWHGWRLLWQHPLEVSALLGAVVLAITGVESIYADMGHFGRRAIMHAWYVVALPALVLNYFGQGAHILAEHAAGHSVDNPFLAIAPEGAARLALMLLSVLAAVIASQALISGTFSMIRSAIQFGFFPRLKVLHTSAAHRAQIYIPLANAALCIGSITIVLAFQTSSSVAAAYGVAVTGAMVITTFAFYLVAQRAWGWSRARALPLCALFGVVDLAYFYSNLHKFADGGWVPLAISVALLVVMHTWRSGKNEVFARVYANDITEDELCNIAASPHITRVRGTAVFMAGNPKGTPLVLLHHVKANKVLHETVVLLSVMTSDAPYVPANERIEVRPIGENGVWRAIAHYGYMESPDVAALIEQLRDQGGVPLVPAEATYYFNREMIMSGGVARLPEWQKHFYGFLSRNARQARDYYQLPPMQIIEVGLPIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKC2</accession>
    <name>A0A139SKC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712664.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06760"/>
    <dbReference type="EnsemblBacteria" id="KXU34934">
        <property type="protein sequence ID" value="KXU34934"/>
        <property type="gene ID" value="AXK12_06760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="146" mass="15495" checksum="2B968BEFCEAA1E55" modified="2016-05-11" version="1" fragment="single">MITSLLGKKLGMTQVYDANNVLVPVTVVEAGPCSVVQVKTTERDGYNAVQLGFATKKDKNASLAELNHAKKAGLDSAPRVLSEVRLDSAPEAKPGDTVTVEIFSEGQFVDVFGTSKGKGFQGVMKRFRVGGGPASHGSMFHRRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD6</accession>
    <name>A0A139SKD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">AXK12_00165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712358.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00165"/>
    <dbReference type="EnsemblBacteria" id="KXU35021">
        <property type="protein sequence ID" value="KXU35021"/>
        <property type="gene ID" value="AXK12_00165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="275" mass="29146" checksum="4732CB034F9A8C81" modified="2016-05-11" version="1">MAAAVVASSRIQKTFSRTQAEGRAAFVAYLCAGDPDLETSLAACRTVIENGVDVLELGVPFSDPLADGVTNQLAAQRALRAGIGRKQVFELVRRIRAEFSELPIVLYTYYNLVFANGIDDYVREARAAGVDGLLTLDLPPEEAGELSAACEEQGLQTVFIVAPTTPAERVTRIVECTTGFIYYVSREGVTGTRDSLVAGLGEAVAKIKARTTLPVVVGFGISKREHVQVVGTVADGVVVGSLLVGTIADNIGSTERVCAALAEQMRELSPGLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD8</accession>
    <name>A0A139SKD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712459.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34957">
        <property type="protein sequence ID" value="KXU34957"/>
        <property type="gene ID" value="AXK12_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="257" mass="29908" checksum="E45E36355EA10C40" modified="2016-05-11" version="1">MTTLIKLPKALAFILLLPLLSAVGLAETVTVYLENGTERQISINIPMTQFGKSDHYRKAYVLEYMEWWNIGIGLSTRNLPYTFDREKYKNTTPPLEIDKRVEQAVRDHFLKGNPRKGDSFYRKVEREAQAYLQKVRYTGDQNVSEMVVDKIGGLGLQPNIKVPIPPRFSSRAEEYAKAYAIQYMRHWNSLWLEKSDDYPNLSITRNSYDFGRYERREPFVSGDIKKYVEQVFAREGIDNKVADALEEHLKAQSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF2</accession>
    <name>A0A139SKF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712392.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00270"/>
    <dbReference type="EnsemblBacteria" id="KXU35038">
        <property type="protein sequence ID" value="KXU35038"/>
        <property type="gene ID" value="AXK12_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="323" mass="35089" checksum="7FFD165817BE31AE" modified="2016-05-11" version="1">MPRDTQPLFVQKHLLILGCGYLGQYVAREALWRGMRVTALTRNETHAVALRAQGLGVIVADLASEDWHALAPREVDYVLNCVSSGAASAAARAALSPASASEDKLAARRRSYVDGMRSLTRWLRDAERVGTIVYTSSTSVYPQGGGAVVDEDSPTVPPDTNTRAGILTAAEQRLQRDCPPAPKRWFILRLAGLYGPGRSHLLDQVLKNAPSLGPVSQRLNLVHVEDAAAAIWAAFAAPATFANRVYNVADDAPAPKCEVLTWLAEQVGPISPDSAKTATVSAAQRSSRQVLDRIISNVRLKREIGWQPRYPDYRAGYAKMLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF4</accession>
    <name>A0A139SKF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00115"/>
    <dbReference type="EnsemblBacteria" id="KXU35052">
        <property type="protein sequence ID" value="KXU35052"/>
        <property type="gene ID" value="AXK12_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="40815" checksum="012F0F252B0DA8AC" modified="2016-05-11" version="1">MLGACLAAVGLFGFVLLLGNAIRDLLGGVLAGQLPALVFLKLLVLLVPYVAAYALPMGILTGVLLTLGRLSADSEITAMRAAGISVWRLSRAIFALGLLGSGLGLYLNFEAMPRARTRYQHELAETVRANPLRFIIPRTFIRDFPGFVVYVGEKEGAQLRDFWLWELDAQQRVHRIVHAENGQFDFDEEGNALLLSLHHVQVESRDRANPEDFSKPPLVGTFERTEQVRLPLDSIFARRSVRQKLKWLSYSELRRRAAEISQNATPEGLRQKMELRLVIQEKQQNALAILSFALIGIPLGIRISRRETSANLGIAVALSLGYYFLTVAINWLDRSPELRPDLLLWLPNLLCLGLAALLFRRIGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKT5</accession>
    <name>A0A139SKT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712124.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05645"/>
    <dbReference type="EnsemblBacteria" id="KXU35188">
        <property type="protein sequence ID" value="KXU35188"/>
        <property type="gene ID" value="AXK12_05645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018760">
        <property type="entry name" value="DUF2326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10088">
        <property type="entry name" value="DUF2326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2326" evidence="2">
        <location>
            <begin position="455"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="598" mass="68528" checksum="6188238BA302033A" modified="2016-05-11" version="1">MKLSKLYSNKPDVFEPVDFAPGLNVVMAEIRLPENRNKDTHNLGKTTLGRLLDFGFLAGKDPKFFLLKHFDLFKNFVFFLEIELEDGSFITIRRSVEDATKIAFKQHEAGHQDLSALALAEWGHRDVPFERARKLLDGLLDWRALKPWSYRKALGYLLRSQEDFREVFQLRKFASKHADWKPFLAYLLGFDAKLIADHYAKEHELAKKQATAQTIKNELGGSVEDISKIEGILLLKQKDAEKKQVLLDAFDFRAQDKDHTKKVVDEVDERIAALNSERYSLSQNRKKVQASLQEDQILFSPDEAQRLFGEVGVLFQGQIKKDFQQLIAFNRAITDERRGYLQEELAEIDEELKRVSAELNALGKKRSEMLSFLSGTDVFTKYKQLSDEMVALRADITSLEHQKGHLHRLQALRTEIRSLTEERDHLQERIQADVDKQNSDQASLFSMIRIFFSEIVEEVIDRKALLSVAINQAGHLDFKAEILDESGNATSADLGHTYRKLLCVAFDMAVLRAHLGEKFPRFVYHDGVLESLDDRKKENLLTVVCRYADLGLQPVITLIDSDLPVRAEDKAPVFTAGEIVVTLHDEGDHGRIFKMRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW0</accession>
    <name>A0A139SKW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35186">
        <property type="protein sequence ID" value="KXU35186"/>
        <property type="gene ID" value="AXK12_05625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="225" mass="23814" checksum="9A459B5A6B9BAB74" modified="2016-05-11" version="1">MTVKIEELIGGVWVQRALEMFWGGDGPHVPHADAWAIRLSLYRDSSLGELLDQRIVPIAADSGTAGPPGIPGPKGDKGPKGDQGDKGPPGPPGANAPAPTLRGLSFEANGDVSFTGQGPYVHGTAAAISCAVNNNNKLFDKWEKAGGPGNINQVSNVNASSTSVLMTAEIKLRAKLKNKEPQTVEELRATAQHPPDQVRPFGLLGNLAQKTLSTFLDFSRRPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ2</accession>
    <name>A0A139SKZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712196.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05820"/>
    <dbReference type="EnsemblBacteria" id="KXU35219">
        <property type="protein sequence ID" value="KXU35219"/>
        <property type="gene ID" value="AXK12_05820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="16784" checksum="182D8D2E61C3E509" modified="2016-05-11" version="1">MRVAVFSDTHDRFPLGLAERFSVGSADEIWHLGDVCEPSGLVEFEQLGVPLRVVQGNCDWDVRWPLSLTLERAGLRFYLTHIPPSPSEVRRDVHAVLHGHTHQPRDEMIGGLRWLNPGSASQPRGGSRAGFAWLEVEGGRLTRWERVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL17</accession>
    <name>A0A139SL17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712257.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05980"/>
    <dbReference type="EnsemblBacteria" id="KXU35246">
        <property type="protein sequence ID" value="KXU35246"/>
        <property type="gene ID" value="AXK12_05980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="492" mass="54885" checksum="FD00F2E0F0C5A6D9" modified="2016-05-11" version="1">MNKTLLLIIIDFLFLNLIALTQWEKVEVSRPPVPLGPQIVAEPGDGPSPIENDLVAAMQLSLADEAARRAALAAELGTLSENLAEREAQLVQTESALQQREQNLSLLTEEQRAAELAAREREAEAALLAEEIQRALAQAQRDAALSREQMERLRRELEMKEAEAQAQAAEMARLEQERAAEAARVAAAQQEIQGLTVAVQVAEQEKQFLQQMAENFRGQAELEREDRVRVQEHTVRLAQGIGELAEEADGLKREIRENRPINANIIFDEFLKNRVTVFLSASRPGVLGQVKRNRHPRSILVNDGEQIFILLHIEDSPFSVAEQASDWDRLRIAVSNYGNNRAEVERISFLDSDPRLVALPLTQEQAEALGMKIYNLASDPFKFPEAVLVSGGGAGYGETPFKLNPAYANYVKLDNRLINRLMGNFSPSRGDLVFSKSGELLGIMVNKDYCAIVTKLEARHSIKTGDNIRAQQTRHVLNFVGGRYRALPVQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL19</accession>
    <name>A0A139SL19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712286.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06065"/>
    <dbReference type="EnsemblBacteria" id="KXU35261">
        <property type="protein sequence ID" value="KXU35261"/>
        <property type="gene ID" value="AXK12_06065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="348" mass="38865" checksum="81EEA63D240A8F5A" modified="2016-05-11" version="1">MPRPVTLFTGQWADLPIAELAPLAKKMGYDGLELACWGDHFDVDQALNNPKYVAEKWQLLLDNGLSSYSISNHLLGQAICDRIDERHQAVLPPDVWGDGDPEGVRQRAAAKMIVTGQAARKFFDAKPGLSDADKGKTAVVNGFTGSSIWHSLYSFPPTPKSYWDAGFADFAARFGPILEAFDKVNVNFALEVHPTEIAFDAASAQMALDAVKGHRRFGFNYDPSHFGYQGVDYVGFIRRFADRIYHAHMKDVWWGHGDGTVGVFGGHTEFGDARRAWDFRSVGRGDIRFEDVIVALNDIRYSGPLSVEWEDIRMDRVHGATESAAFVRRLDFPRNDVAFDAAFDKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL30</accession>
    <name>A0A139SL30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fucose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712290.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06075"/>
    <dbReference type="EnsemblBacteria" id="KXU35263">
        <property type="protein sequence ID" value="KXU35263"/>
        <property type="gene ID" value="AXK12_06075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="421"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="542" mass="59965" checksum="4CB32A4AD57A30FE" modified="2016-05-11" version="1">MKKLPAKTIQLIANGDLRQSANQATWPLQAAMEKQLTQAVAALGYKLLRAHPYKPKLGHGFIGSQKEGMQVFAKIDPRRPLIVAESVWQYSHHILHGLISHRGPILIVANWSGSAPGLVGMLNLNGSLTKAGVPYSTLWSEAFTDAFFLKNLEQWLKTGKVVHKQNHVRPLARCTLPTRAKTLGKKLAAELRQRKSIMGIFDEGCMGMYNAIIPDELLFQTGVYKERLSQSALYYETTQISDSEARDVYAWLKEKGLKFHLGEDPATELTEAQVLSQCKLYIAALRIADEFGCEAIGIQYQQGLKDLLPASDLVEGLLNNSDRPPVKNAAGKEILPGQPLTHFNEVDECAGLDGIFTARVHRALKQPVENTLHDLRWGAPAHTGTVDDYVWVFLISGATPPAHHIGGYAGSDSHRQPPMYFRLGGGTLRGIAKPGEIVWSRIFIENGKLKMDLGRAKVVELPREETERRWRETTPQWPIMHAVTYGVSRDQMMARHKANHIQVAYATDAASADLALYTKAALAKELGLEVSLCGTKADGSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL41</accession>
    <name>A0A139SL41_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="10" type="ORF">AXK12_05670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712318.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05670"/>
    <dbReference type="EnsemblBacteria" id="KXU35276">
        <property type="protein sequence ID" value="KXU35276"/>
        <property type="gene ID" value="AXK12_05670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="267" mass="27135" checksum="CA955148C79CE181" modified="2016-05-11" version="1">MPSSPTLGSLLAKLRRERPLVQCITNYVAMNTAANVLLAAGASPAMVHAEAEAAGFARLAAALTINIGTLSPSWVEGMRGAAKAAQTSGKPWVLDPVAHFVSPFRRDVVAELVALSPTIIRGNASEIIALAGQANHGSGADSGDSVAAAEAAARELARRHKAVIAVTGEIDFVTDGARASHIYGGSPLMPQVTALGCSLTALIGAFAAVSPDDTFTASLAALALFAVAGERAARSAAGPGSFSWQFLDALAALTPEALDAEARIVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL68</accession>
    <name>A0A139SL68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">AXK12_05490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712072.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05490"/>
    <dbReference type="EnsemblBacteria" id="KXU35302">
        <property type="protein sequence ID" value="KXU35302"/>
        <property type="gene ID" value="AXK12_05490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="12925" checksum="B520EC6ECD05B069" modified="2016-05-11" version="1">MSNITKDQVIEWLSAQPVLELAALVKDLEEKWGVSAAAAVVAAGPAAAAAAPAEEKTEFDVILAEAGGNKIGVIKEVRAITGLGLKEAKDLVEGAPKPIKEGAAKEEAEEIKKKLEAAGAKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF4</accession>
    <name>A0A139SLF4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05590"/>
    <dbReference type="EnsemblBacteria" id="KXU35320">
        <property type="protein sequence ID" value="KXU35320"/>
        <property type="gene ID" value="AXK12_05590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="287" mass="31489" checksum="17AA6FA0946ECF61" modified="2016-05-11" version="1">MFSACDPRDKGPQGAEIDDPNYRLGQRLVKQGRSQEALAAYLRVIAERGEAAPESHLEAGIIYLQQIKDPIAAIYYFRKYLERSPNSPQAPQVRGLVEGAKREFARTLPANPLENQSERLDMVEQINRLQRENEQLKAELLSAVRSAASQPSSVTQVRVPTNGVLLVPSRDSAAQQASAARLTHEPPPRPAQDSPLSLAPIRSSVVSTTPSAPTRPRELASAAGGRNAASTTAAAARRHVVVRGDTLFGLAQRYYGDRARWRDIYNANREILPNENSLAVGMELRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF8</accession>
    <name>A0A139SLF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">AXK12_05240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711963.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05240"/>
    <dbReference type="EnsemblBacteria" id="KXU35377">
        <property type="protein sequence ID" value="KXU35377"/>
        <property type="gene ID" value="AXK12_05240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="14">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="657" mass="72377" checksum="D809907BE17FDB96" modified="2016-05-11" version="1">MPVIKPSCVRDLKLRVPIADVVSRVVTLRGTGGRRMKGLCPFHNEKTPSFHVDTDKGFYKCFGCGQAGDIISFVRETEQLGFSEAVETIGQRFGIEIEYEEGSGGPSREERSLRSELFELHELAADHYHQAFRVSSPLGDFMRHYWSDSRHFDLAIAEEFRIGAAGADGADTLAALLLKKRFSEDALRHCGLFFIRDGTPISPATLRPRFRGRLMIPIRDHQGRVVAFTARQTALTPSDDPARDAKYTNSPETPIFTKGNLLFNLDRARSAVGEGRPFVLVEGQLDAIRCWSIGLKTAVAPQGTAITDTQLRLLRRYHAQIECFFDGDSAGQKAALRFLPLALRAGLEARFLVAPDSGNIGDNSAATANTPPPLDDPDSLFLAQGLAAYDALHQGSLSAMHYAARALLPVPTHATAEEKSRAAHALMEIIANAESQVAQSEFVAEAAAHLRIAPHAMQRDFHRLKLRRGRGTAARAALGERAPNPLSADTRPALDGEPTTRRQEKEPKTPPEEHLLLVCLHFEQIGPALAQTLPHDWIDTRHTAGALLNRFLAEFEQANWPGRDHLDPLLETDAERALVTTLLFDPPAFEDPHKIASEALRLLRARALEPRLHQIALDLARHDADSPAPPNLGALLQEQLEIKRQLLRPLLLSTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS4</accession>
    <name>A0A139SLS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05090"/>
    <dbReference type="EnsemblBacteria" id="KXU35498">
        <property type="protein sequence ID" value="KXU35498"/>
        <property type="gene ID" value="AXK12_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020992">
        <property type="entry name" value="Tail_Prtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040573">
        <property type="entry name" value="TSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11818">
        <property type="entry name" value="DUF3340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17804">
        <property type="entry name" value="TSP_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="328"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="908" mass="99225" checksum="2C3717530D62B6D5" modified="2016-05-11" version="1">MTTQKNAVLRSEPFAQSLSQSGTHALTLTPPLPFPTPTLFSPHASPALMTRRRHRTPRSLLPLLLLGLAVALLSPRPAQSQSQAQAPRAAKAAPTANATTTTATTTTAAPRISSSTADRREFTTSPALSTEARILVQLLSQAHYNRDTVRSSSYIEVIKDYMSALDGQRMFFLKSDRDLFEKKHSTSLYWNVSRLGNIDAAYEIFSRYELRAHERVDWIFRNIDAALADLDSDDHHRIDRRKVEWPDSPAEADSLWLNRLKFELIAELLNKRSPEKAAEAVRTRYERLLKNLAETETSDVGEMFLATIARLYDPHTAYLSGDTFEDFNIQLKLELVGIGALLTVEDDYCVVKELVPGGPAALGGELKANDKIISVAQGEDGDFLEIIGLKLRKIVDQIRGEKGSTVRLLVQPGDATDPAARREVLITRDTVKLNSARAYAGLFQVPTGEHIAAPSGDATDHSPSTARTAPIGVITLPSFYGAAEEGGPDGEENSSATHDVARLIAQLQAQGIQGLVLDLRGNGGGLLNEAIDITGLFIPRGPVVQVKSYSGEIRVSSDESPTIAYTGPLAVLVDHFSASASEIVAGALQNYGRAIIIGDRSTHGKGSVQALEEMRRYVPQLARSGAKTGATKFTVQKYYLPNGDSTQRKGVVPDIILPSIEDHLPIGEAELPRALAWDEIPSTFFDGAPIDDNLLATLRDASLARQNSLEEFDYLRRNIDWFKQRQDEKLVSVNLEKRRARRDEDKALRKAFLAERKRLAALDYAYEEFWLSPPEERQTTTATKNADGTASVEIDEAATDAADDDALLAEADTTANVNDASRAEPANDSASPTREISDTLLASDGTEDSPASDDDDDLEEEEDDTGAYAKVDVHLKESLRVVADVIALGHDPSNWIHNAPPLTARTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM43</accession>
    <name>A0A139SM43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711812.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04835"/>
    <dbReference type="EnsemblBacteria" id="KXU35646">
        <property type="protein sequence ID" value="KXU35646"/>
        <property type="gene ID" value="AXK12_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="161"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29275" checksum="F36930A1FAB645F2" modified="2016-05-11" version="1">MDKKIGVIGLGIIGRVWAGHYAAAGVLGGTWNRTPRAEAPLPLGSPEAVARAVDVVQIVVADPAAVEAVLARVVPELGPGKVLVQSSTIDPQSSERFRAQVVATGARYLEAPFTGSKPAAEARQTVYYLGGEAGLVAELDALLGTVSSLRLHVGDHQQACALKLAMNLNIAAQMQALCEALTLVRRAGVADEVFFNALRPNVAYSGVTKLKEPKLRAEDYAPQFSVKHMLKDIRLSGLTASEGSSDPFAVRAAVLGRLAAADAQGYGEEDICALLKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB9</accession>
    <name>A0A139SMB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ORF">AXK12_04925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711840.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04925"/>
    <dbReference type="EnsemblBacteria" id="KXU35659">
        <property type="protein sequence ID" value="KXU35659"/>
        <property type="gene ID" value="AXK12_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="316" mass="33303" checksum="88F7FF26DB6407B1" modified="2016-05-11" version="1">MTLYESRVAVAPEAVEGIDEAIQEAGLLGWNLVGDVIERTAALVGLFPSEQEGQAAWAELVAACPSLAGAQPQLRKIAEEEWREGYRAHFKAWQFGRLHWVPVWHKPQASASGAGALAGVEAQRSADDHTGFIAPDGHEVLWLDPGLAFGTGNHETTRLCVERAVAFSEGRIDLAATRVIDAGCGSGILALSAAKLGFGSVVGFDNDPEAVRVSEENAALNALTGAVTFYEGDLVSGLAGRQAELVLANILAPVLIEFAANLVAAVAPGGTLVLSGILASEGEQVRTAFARAAADWHFEESRVLGEWCDVVCVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMC1</accession>
    <name>A0A139SMC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711873.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05005"/>
    <dbReference type="EnsemblBacteria" id="KXU35610">
        <property type="protein sequence ID" value="KXU35610"/>
        <property type="gene ID" value="AXK12_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005618">
        <property type="entry name" value="OMPW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36920">
        <property type="entry name" value="PTHR36920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03922">
        <property type="entry name" value="OmpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299348" evidence="1">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="203" mass="21850" checksum="67E6CDFC739605F0" modified="2016-05-11" version="1">MKANTIKTLLAAAASVVLLGSTGFSQAAGTWNLGLGVHNISPKSSNSQALGGARTTVDDDLQPTITLEYFIYENLGIELLASLPFRHSVKAGGDYIGQTKLLPPTLSVQYYFVNASKFTPFVGVGLNYTTFFDTRASGFDLAAEDSWGFAAHAGVDYKLTERSSIRLDARWVDVETELKANGAKLGKLALDPIVFGAAWVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMC2</accession>
    <name>A0A139SMC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_04815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04815"/>
    <dbReference type="EnsemblBacteria" id="KXU35691">
        <property type="protein sequence ID" value="KXU35691"/>
        <property type="gene ID" value="AXK12_04815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="261" mass="27933" checksum="5792FA9DC07DA8CB" modified="2016-05-11" version="1">MNLVLFQPEEIARALPRGDARAEHILGVLRRRVGDSLDVGLANGPRGKATLLSITASALDFAFSWEPAPPPQPPPTTLIIGLPRPQTARKILQDSAALGTRALHFVRCERSEASYADSRLWSSGEWQRHLEAGAAQAFCTHIPQVSHGHTLAEVIREFTLPTETATTPPKTGSAPRPHGVKRSVRVALDNYEASAALSSIALEADTPLIVALGPERGWSGSERDTLRDAGFTLAHLGPRVLRLETAVTASIAITAAARGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMC7</accession>
    <name>A0A139SMC7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ORF">AXK12_04825</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711808.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04825"/>
    <dbReference type="EnsemblBacteria" id="KXU35695">
        <property type="protein sequence ID" value="KXU35695"/>
        <property type="gene ID" value="AXK12_04825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="694"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="952"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain" evidence="13">
        <location>
            <begin position="569"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1092" mass="118259" checksum="E72A019EB29F5B8A" modified="2016-05-11" version="1">MPKRSDIQSILIIGAGPIVIGQACEFDYSGTQACKALREEGYRIVLVNSNPATIMTDPEFADVTYIEPLTVEILEKIIATERPSALLPTLGGQTALNLAMELHEAGILEKYGVEMLGAKPEAIAKGEDRELFKQAMLKIGLDVAHSCVVKTMDEARAAAEEIGSYPLIIRPSFTLGGAGGGIAYNKEEFEHITANGLDLSPVHEVLIEECLLGWKEYEMEVMRDHKDQCVVICSIENFDPMGVHTGDSITVAPAMTLSDKEYQAMRDASFAVIREIGVATGGSNIQFSLDPKTGRQVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELRNDITRVTPASFEPTIDYVVTKIPRFTFEKFPDADSTLTSAMKSVGEAMAIGRTFKESMQKALRSLEIGARGFGGGGGKYGLDTPPDESEIRARLATPNAERIFYIRYAFMVGMTVDDIFELSKIDPWFLHQLREIYDMERALKNAGSAAEGAKAGGAALAALDPVLLRRAKQFGFSDVQLAHFLGCEPEAVRARREALGLGTSYRLVDTCAAEFEAFTPYYYSSYGDENEIGAPSAKPKIMILGGGPNRIGQGIEFDYCCVHASFALREIGYETVMVNSNPETVSTDYDTSDRLYFEPLTLEDVLEIYTQEKCDGAIVQFGGQTPLNLASALKARGVNIIGTSPESIDTAEDRKRFAAILDGLDLKQPANRTAMNQEEALHFAREIGFPVLLRPSFVLGGRGMFIVYNEAEFQAVIRQAFEVMPDKPVLIDQFLEDAVELDVDCISDGETSVIGGMLEHIEFAGVHSGDASMVMPPHTLGAEILDTVRRATHALARALQVVGLMNVQFAIKAGQLYVLEVNPRASRTVPFVAKAIGVPLAKLAAKVMAGKTLKELGFTRELSPKHWCVKEAVFPFVRFPGAMITLGPEMRSTGEVMGLDADLGRAFAKAQAAAKPGLPTSGNVFLSVKDADKPRAVKLARELAALGFALYSTSGTAKVLEENAVPVTRLAKIDEGRPTAVDMVKNGQIQMVINTPGGMIPRRDENAIRAASYAHSVCIMTSITGAEAALNGIRALSTGQLGVKPIQHYKDNVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMY2</accession>
    <name>A0A139SMY2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">AXK12_00075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00075"/>
    <dbReference type="EnsemblBacteria" id="KXU35854">
        <property type="protein sequence ID" value="KXU35854"/>
        <property type="gene ID" value="AXK12_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="342" mass="38178" checksum="B95F96B6286BF69A" modified="2016-05-11" version="1">MSAPDFWDNQDRAQKHIAALNGLKRAVLPLVAFRKKVDDLDVLAEFAESSEGTEQESYERELEQTTAALLAELDGLEIASFLTGQFDRNNAILSIQAGAGGTESNDWAAMLFRMYTRWAEERGFTAEITDVQEGDQAGISRATLILSGENAYGYAKAERGVHRLVRISPFDSNKRRHTSFCAVDVVAEVDDTIDIDIPESEIRVDVYRSSGKGGQGVNTTDSAVRLTHLPTGLVVVCQNERSQIKNRASALKVLKARLYEKRLDEQRSEMERFYGEKGEIGWGSQIRSYVMQPYQMVKDLRTGVSTADVSGVLDGELDSFVNAWLRAGCPRHRNKDIQMEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA0</accession>
    <name>A0A139SNA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711700.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04620"/>
    <dbReference type="EnsemblBacteria" id="KXU35970">
        <property type="protein sequence ID" value="KXU35970"/>
        <property type="gene ID" value="AXK12_04620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="525" mass="59947" checksum="43FED1EECF383587" modified="2016-05-11" version="1">MANRKGYARLAPLMTKHLHFRTALCTLIVCTGLGAVHGSPHKPAQRNPELRKNTEERPGERQFFGPLAATGAAPTGGHYSTIRPLWLRQESDGELDAAGQKIPTSVEHSFLYPLFSYKRSANGTVDWSLFKLVNFSGESRTRVGDDASLSFELWPVYASKQTGTPETSYRAVFPIAGQIKSRFGYDSLQWVLFPLSFRSEKAGRVTHSALWPIFKKRSGEGHTGFSVWPLYGVAQKEGAYRNRYFLWPLIYDSVRYGAATSASTGAAPHPAHHSLGVLPFYAREVRPGSISESYLWPFFGYTRQDAPLAPYQETRYLWPLFVQGQGSEHRLNRWAPFYSHSVRRGIDKRWFLWPLLRHETWREQDLIRTKDQVLFFLYSSERQRSAAQPDLPAAHKTHLWPLLSTWNNGAGRAQTQLLSPLAVFFPNNEKVQLLYNPLFALYRHDQQTPDEVRHEVLWRLVTWRRSGKTRELRILGPTLGLRKNAAGEWRPFLFDFSRKSRTLDATTETPAAQPPRAANPEPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND2</accession>
    <name>A0A139SND2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711613.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04420"/>
    <dbReference type="EnsemblBacteria" id="KXU36069">
        <property type="protein sequence ID" value="KXU36069"/>
        <property type="gene ID" value="AXK12_04420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="222" mass="23910" checksum="CCB3EEDCF5D584F6" modified="2016-05-11" version="1">MEPVYGLFHYLFASAYGMFFRGEVEGQAHLPREGGFLIAANHASFLDPPMIGAQVSRQLAFFARKTLWGNGRSDNKWLSLGGFASWWLDTVGTIPVDRDGGQDVSAIKRVLGALKTGRGLILFPEGTRTSDGQLQAPKAGVGLIACRAQVPVVPARIFGSREAMGKGQPLRLGTPVSVVFGPPILASNYDPGSSAGKERYQVASERIFEQIAALEAPTRHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNL4</accession>
    <name>A0A139SNL4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711638.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04490"/>
    <dbReference type="EnsemblBacteria" id="KXU36082">
        <property type="protein sequence ID" value="KXU36082"/>
        <property type="gene ID" value="AXK12_04490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="78" mass="8567" checksum="AF83BB4B175D1AD3" modified="2016-05-11" version="1">MESLRAYLQKLAVPQQHEYAERAGTSLGYLRKSLSVGSRFGGVLARRLDEASGGEVPRYELRPDIFGEGPEEAAGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM2</accession>
    <name>A0A139SNM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711596.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36061">
        <property type="protein sequence ID" value="KXU36061"/>
        <property type="gene ID" value="AXK12_04370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299378" evidence="1">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="301" mass="32590" checksum="284C054FA492187F" modified="2016-05-11" version="1">MLRFSQRAFCFMLLLATGLAVSPPGDYEAELTEWHAQRVARLTAAEGWLSLIGLHFLSEGEQQVGTAEGNDIVLGAGPLSLGVIDLQPSGRVMLRVTPGAGVRVDGREVLSEELIPQGRGPRGQTTTVSCGSMSFYVIVRGGRMALRVQDTASPRRRGFAGIERFPTDESWRVEAEWEAFAAPREVTITNTLGQESQALVLGRAVFEREGQRLALLPLQETLGEPLFFIIADETSGHETYGAARFVYADPPDESGRVIIDFNKAINPPCAFTPYATCPLPPSENVLSIAVRAGEKAPLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP9</accession>
    <name>A0A139SNP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TbpB_B_D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711656.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04545"/>
    <dbReference type="EnsemblBacteria" id="KXU36091">
        <property type="protein sequence ID" value="KXU36091"/>
        <property type="gene ID" value="AXK12_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001677">
        <property type="entry name" value="TbpB_B_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01298">
        <property type="entry name" value="TbpB_B_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TbpB_B_D" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="84" mass="8577" checksum="01A285F8E6058AD4" modified="2016-05-11" version="1">MNFATGWGFGSIVGLAQSGKVDLEAAQVMGNRINGKATVAVAPNADVDYTLGFYGPNAEEVAGAVWTNDPALEGASEIGFGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR4</accession>
    <name>A0A139SNR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03855"/>
    <dbReference type="EnsemblBacteria" id="KXU36198">
        <property type="protein sequence ID" value="KXU36198"/>
        <property type="gene ID" value="AXK12_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="310" mass="34994" checksum="6F9DEE81FAEF42B7" modified="2016-05-11" version="1">MSLAAEARVPSPAPAALPPQLKIATYNVENYGSLNRRTPHGFRANYPKSEAAKRALRQTIREIDADILVLQEMGPVEYLLELQRDLKAEGSDYPYSVLMRGPDAARHIAALSRIPFARVHEHSPLRFEYQDGVEDVKRGLLELHFATPAGPLTLWALHLKSRYTTNKADPESAIRRAAEAMRIREFILQRIADTQADLYLILGDFNDTKVSPPLRYLMQRSELKFSHLLPSSDSRGEHWTYHNTRDDSYSRVDHILASSAVLPFVKNGSAEIADGPQVRSASDHRPIFVTLDFSAFPQSPNWEVPRSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNW4</accession>
    <name>A0A139SNW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_03680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711348.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03680"/>
    <dbReference type="EnsemblBacteria" id="KXU36247">
        <property type="protein sequence ID" value="KXU36247"/>
        <property type="gene ID" value="AXK12_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="10">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="595" mass="63544" checksum="489CEF1456785587" modified="2016-05-11" version="1">MSQTAPSPDLVTVNIDGQEIAVPKGTNVIEAARKLAVDIPHYCYHEKLSVAGNCRMCLIEMGMPAVDPATKAPIIDEATGKQKVNWIPKPVIGCGTNVSPGMHIRTTTPMVKDARESVMEFLLINHPLDCPICDQAGECKLQEQATGYGRGYSRYIEPKNVKPKRTVLGPRVTLDDERCILCSRCIRFSREIAKDDVLGFTERGSYSTLTCFPGRELANNYSLNTVDICPVGALTSTDFRFKMRVWFLKQTNSICTESSVGANTVVWSREGTIYRITPRQNDAVNDTWMTDSGRMLYKEVQAENRLTRPLVRGVAVTADAALDAATELLRSAQPGTVAIVGSGRSSVEEQFLTRKLAEALGDKVGAPVSVVSRVGEGDGLLLSADRNPNLRGALITGLIEALPPTYAPLAALAAAIEAGEVKTVISVGEDLAEAGLSAEQLAKVSVIYLSTHANATSQAAAVVLPTLTVFEKSGSFVNQQFRIQKFAQAVPGPAGAADDLATLSALIAIAGGGRGGPVSDRNAVPNGRVETLWKALAAEVPAFANVTYQEIPDDGLLLDATPYASLPFVEGETLHHKPTTPISPLNERATTSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ4</accession>
    <name>A0A139SNZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711383.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03610"/>
    <dbReference type="EnsemblBacteria" id="KXU36266">
        <property type="protein sequence ID" value="KXU36266"/>
        <property type="gene ID" value="AXK12_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="158" mass="17728" checksum="7DDF5D26E6F3E5A1" modified="2016-05-11" version="1">MRCLGIDYGTRRIGLSFGDEVGVATPLPALVQGEAEARWAALERVVRERRLTDFVLGYPFNMDGTVGFKAREVDQFAAELRARFGLPVHLMDERLTSYQAEAEARPSKRGARAQRQFRASGVVDSRAATLILQDFLNQRVPPPVPEFYEEEEVNDEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP08</accession>
    <name>A0A139SP08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711454.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36181">
        <property type="protein sequence ID" value="KXU36181"/>
        <property type="gene ID" value="AXK12_03975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="533" mass="59110" checksum="3338BB77AEECD7A3" modified="2016-05-11" version="1">MKGWILDIFRTVWALFYWNLRKTTYALSVRRSGAGAGISGPAPCQDASDSGEGMKTGCEACRTWARRSRFQRVCPLLTQTAEGYWLCGVDATKVRPFWGRAFGYFGGSVVTMLILAVAVLYGTMHGIGYDVSIRQLVWPLAWRELRGVRAELFIKQARESYKAGEIQQAIQALVVAYQLNPTDLKTAMTLAQFYQISRPSQADVLYQNVLIQHPEAGDEASQVWFHSLLARGRLDVIAELAQQRLAANTPQAPTWSYALIFAARMMPEKVDLAALADDTAIPIAPRGVFYLASRVEQRAKFSAEAARKELLEAAPVAGFPLDRIYRVEALLRLGFAEDALQLMSQWKDDFSGRDMGRLLLRAYSVMGEHEQLRAEFRAMLAPTRELRSPELTMMAVHLVHFPDASLTRLLVEALPRLKSTEDDSGQWLEAVNAVFCAAGVNGDKEGMASVRQLLVDTYGVSGTILEILALFFQGDSEIMQIGTILPHLRPLVTDLNYALLERYGVPRSEQFEVEDPALAPSRASGGPPPASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP83</accession>
    <name>A0A139SP83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711240.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03325"/>
    <dbReference type="EnsemblBacteria" id="KXU36415">
        <property type="protein sequence ID" value="KXU36415"/>
        <property type="gene ID" value="AXK12_03325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="431" mass="46518" checksum="EE86ED03F3D17180" modified="2016-05-11" version="1">MADLIVNGGKPLSGTITPSGNKNSVLPILCATLLTDEPVTLHNVPNITDVEKLLAFFAAQGSQLTWDRDSCTLTVSHRNFDTEQLAGELPAGMRSSVLLFAPILQRMGRLRLPSNAKGCSLGIRELDPHLEILEKLGAKLSQSGDAHTLKLDGRFRAARHWPDYMSVTATENFAMAAVLAEGESVLINAASEPHVQDLCQVLVSMGAQISGLGTSQLVITGVERLRGGTFTINSDHHEVVTFLALGAITGGEVRVRHSVPQHFDLIGRAFGKLGVAIEHEADTALVRARQPLHIAAPFTTNLLPRIEAAPWPYFPVDLLPCMIALAVRAEGTMQFWNKVYEGGFGWMHELAKFGAHIAVSDPHRVIVFGARPLHPTIVDAPYIIRAAVALYMVAASIPGSSVVKNADTIRRAHPNFVGNLRSLGAEVEWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPC2</accession>
    <name>A0A139SPC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711270.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03460"/>
    <dbReference type="EnsemblBacteria" id="KXU36354">
        <property type="protein sequence ID" value="KXU36354"/>
        <property type="gene ID" value="AXK12_03460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="28002" checksum="00BF2AF9369A4C29" modified="2016-05-11" version="1">MLKLLFIGDIVGRPGRDIVNAQLAALRQRHALDFVVANAENSAAGAGITGKIAQSLLGAGVDAITLGDHVWDQREWASEIGQLDRVCRPANLPASCPGWDHLVIEARGFRLGLFTVLGRHFLGMKAECPFLCADRMIEKLRGQVDAILVEVHAEATSEKQALGWYLDGRVTAVLGTHTHVPTADARVLPKGTAFMCDVGMTGPYASVLGREIEPVVGKFLDGMPRRFGVATDDVRLSAALVEISARNTHAQKIELLTVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD1</accession>
    <name>A0A139SPD1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="11" type="ORF">AXK12_03185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711216.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03185"/>
    <dbReference type="EnsemblBacteria" id="KXU36465">
        <property type="protein sequence ID" value="KXU36465"/>
        <property type="gene ID" value="AXK12_03185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="179"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="636" mass="71691" checksum="F2EB86FD35F97E48" modified="2016-05-11" version="1">MTPLEEIRHSCSHVLASAVLRLFPDAKLDIGPPTDTGFYYDLDLDHKLSAEDLVRIEDEMRKIVKENQAFVRKEVPRDEAAALIRQLGQERYKLGRLADIPENEAITFYTNGDFTDLCGGPHVRYTSKLKAFKLLSIAGAYHRGNEKNKQLQRIYGTAFETKEELAAHLERLEQARARDHRKLGKELKLFHIDEEVGQGLVLWLPKGAVIRQELQNFISEELRKQGYSQVFTPHIGKLSLYKTSGHFPYYKDSQFPAIAEPDALAQLADCGCSCAELTARLEGVSRQLADGLNARSGQTLIEDERVMDPERLLDGFLLKPMNCPHHIKIFASQPHSYRDLPVRLAEFGTVYRWEQSGELNGMTRVRAFTQDDAHIFCTESQVAEELIGCLALVKTVLTTLGMGDYRVRVGLRDPDSGKYTGDAAHWDKAEEACRQAARSLGMPFTEEPGEAAFYGPKIDFVVKDVIGREWQLGTVQVDYNLGVRFDLSYIGADNQAHRPVLIHRAPFGSMERFVGVLIEHFNGDFPLWLAPEQVRILPISDKVADYSRALLAKLRAADIRATLDEHSDKLGAKIRRAELEKIPHTLVIGQKEAEQESLSLRSRALGDEGTLRADDYLARLKHEIASRALPPTRQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD6</accession>
    <name>A0A139SPD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="5">5.4.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AXK12_03335</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine = (3S)-3,6-diaminohexanoate</text>
            <dbReference type="Rhea" id="RHEA:19177"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57434"/>
            <dbReference type="EC" id="5.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711241.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03335"/>
    <dbReference type="EnsemblBacteria" id="KXU36416">
        <property type="protein sequence ID" value="KXU36416"/>
        <property type="gene ID" value="AXK12_03335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022459">
        <property type="entry name" value="Lysine_aminomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00283">
        <property type="entry name" value="L-lysine_2_3-aminomutase_(LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="119"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="411" mass="46772" checksum="62BC5D600D7F8F7C" modified="2016-05-11" version="1">MPYKEDRATWYEGQGLWADVPASDWNSWGWQLRNRITTLEQLERYLTPTREERAGILFAKQKLSLAITPYFFNLIDRDDPDCPIRKQVIPRAGEMQLAEEEMLDSLGEDEHSPVPGLVHRYPDRVLFLVTDRCASYCRYCTRSRMVSNAQHYDFHPQHEAALAYIAAHPEVRDVLLSGGDPLLLSDGKLDMLLGRLRAIPHVEFIRIGSRIPVFLPQRVTPELCEIFKKHGPIWMSIHVNHPRECTQALKDACERLAFAGVPLGNQSVLLRGINDDPEVMKALVHRLLRMRVRPYYIYQMDLITGGAHFKADVRRGIEIIEALRGHTTGYAVPQYVIDAPGGGGKVPINPEYLDKITDEEVVFHNFEGRRFRYPLKSTPLVGARVPDEAAPQKPVSEPERVAEPIAEPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPF3</accession>
    <name>A0A139SPF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36469">
        <property type="protein sequence ID" value="KXU36469"/>
        <property type="gene ID" value="AXK12_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="141" mass="16194" checksum="0C41FACC5280B335" modified="2016-05-11" version="1">MNSIRQNSRQGIVSGGVQNGRDSHAQMGKLPTQRIDKFGQRARHRPARPDKERHNHKLAFARLARALVTAHALARVSALQLFAQKRLDALRRYASERGSRNLVRVCKRNRKNGPPDSLRQPPRHLAQREHHSRLQRAIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPH2</accession>
    <name>A0A139SPH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711267.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36351">
        <property type="protein sequence ID" value="KXU36351"/>
        <property type="gene ID" value="AXK12_03440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="7919" checksum="50B9CF90D836125B" modified="2016-05-11" version="1">MLRYEFLTQPKEPAAMTATMTLTEKGIAAVTTNPSAHLAVYGEVKRGHRHMEPKAPLACGGEAPTAGSEFFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPU0</accession>
    <name>A0A139SPU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711196.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03095"/>
    <dbReference type="EnsemblBacteria" id="KXU36609">
        <property type="protein sequence ID" value="KXU36609"/>
        <property type="gene ID" value="AXK12_03095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="291" mass="32769" checksum="2A12D3276018485B" modified="2016-05-11" version="1">MSASTAPSPNATKAARPLKRRQYDWPKHIVLMTLIGIELFPLYMMLQVSFKDTSTFLQQPWLPLPISQWDWSNWSFGIKLIAPYLANTVFVTTCATFGTFFFALLGAYFFARSKLPGKGILWTLFLILLIMPGVGTFVPVFMLLKSLHLLNTLFALIILGVSGGQVLNVFILRHFIEDIPKDLFEAAEMDGASHFQRMVHIVIPMAAPIIGTLSIFAFMGGWNDFMMPLIILRDQELFTLGVGLIYLEGEYVKPWGKIMATYFISSVPLLIMLLFTMKFFVRSFSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ66</accession>
    <name>A0A139SQ66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711180.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03045"/>
    <dbReference type="EnsemblBacteria" id="KXU36745">
        <property type="protein sequence ID" value="KXU36745"/>
        <property type="gene ID" value="AXK12_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="238" mass="25755" checksum="18E6AD48CBB8C9C8" modified="2016-05-11" version="1">MPNAMPASVIADLRFIGLESASVKSLSGFNKKRHTLPDSANATTNAFLARLCAPELAERGEALFQAVREAMGYKRREVSLSIDADGGLARLSARDFSLELFYELEPSSPEFYLFRQTLLDAKTSELLHNAAFNEVFAGTFSELSFTLQKGVQVEAVIDAVEGLDEVGNAAHSPLRVTYPSDCSVCEIAVAGVEARVRCTGASIDMIFPRAGSPLELLQEFAAVRSAFSLSELLRGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ77</accession>
    <name>A0A139SQ77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ORF">AXK12_02770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711134.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02770"/>
    <dbReference type="EnsemblBacteria" id="KXU36698">
        <property type="protein sequence ID" value="KXU36698"/>
        <property type="gene ID" value="AXK12_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU36698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="20448" checksum="50E7DAD452E8D344" modified="2016-05-11" version="1">MLPLLLAVSDAAAQATDAAPGMIETFGLESKFVIMQAISFLILFAVIYKFGIKPTLSTMEQRNAKIESGLKYAEEMREKLTASQRESAEIVQNAQVKAGDIINEARTTAKDFLEKQTQEATQKANDLLTKAQQAIELERLKTIAQAREEISRLVIATTERVLAKQLSDADRAAYNESATRELNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ84</accession>
    <name>A0A139SQ84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711144.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02835"/>
    <dbReference type="EnsemblBacteria" id="KXU36708">
        <property type="protein sequence ID" value="KXU36708"/>
        <property type="gene ID" value="AXK12_02835"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="504" mass="54792" checksum="26FA7F078649FD3D" modified="2016-05-11" version="1">MAKERSDIGLIGLAVMGQNLALNIADHGFQISVYNRTTEKTEKFVAENPDTPGGLVATTTLKAFAASLARPRKAIILVQAGRPTDAVIDGLCEVFEPGDIIIDGGNALWTDTIRREKALKEKGFLFIGSGVSGGEEGARFGPSLMPGGDRDAFKHLEPIWKAIAAKVDKTTGKPLLGAAPGKPVKGGVPCTTYIGENGAGHYVKMVHNGIEYGDMQMICEAYDLMKGLLGLKPAEMGAIFSDWNEGVLDSFLIEITADILKQKDPVTKKPLVDIVLDTAGQKGTGKWTSVNALDMGVAAPTIAESVFSRCLSAIKEERVAASKILKGPKLEKLSPSPAKKKALIEAIRDALYCSKICSYAQGFQLMRQAQDEFGWKLNFGKIAQIWRGGCIIRAAFLQKITEAYAANPRLANLLLDPYFNKTIQAAQTNWRKVVSLAAENGIPVPTFASALAYYDGYRSARLPANLLQAQRDYFGAHTYERTDEKRGRFFHIDWPDPARPQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ91</accession>
    <name>A0A139SQ91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711149.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02865"/>
    <dbReference type="EnsemblBacteria" id="KXU36713">
        <property type="protein sequence ID" value="KXU36713"/>
        <property type="gene ID" value="AXK12_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="13"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="318" mass="32943" checksum="22123D8B13FBE90F" modified="2016-05-11" version="1">MPQNPTTPNSLRLGIDGGGTKTDFILVDAQGELLGQRRAPGSSPSLGNADTITQLIAENIHALIQSTGSTLAISHCCLCMAGSRLFWQDFAKTLAQRLPQLGQVHAFDDSIPILELATASGPGLALHSGTGSFIAARAPDGTAHYAGGLGWRIGDPGSAQDLGRRAAERALGEAQGWATASPLGRAVCAAIRAHHIDSLLREIYAEDGSHNTPAALAQLSPLVTEHAAQADAAAITILRDSVSALAQIAKAVSERLFGKESPPKDAPTAAAIPVGLSGPILRSTLAQQTIAETLGPTHPLHPITDAPLEGLRRLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ97</accession>
    <name>A0A139SQ97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4878 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711171.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03000"/>
    <dbReference type="EnsemblBacteria" id="KXU36736">
        <property type="protein sequence ID" value="KXU36736"/>
        <property type="gene ID" value="AXK12_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024267">
        <property type="entry name" value="DUF4878"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12870">
        <property type="entry name" value="DUF4878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4878" evidence="2">
        <location>
            <begin position="78"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="215" mass="23956" checksum="B1C02FD007D8F43E" modified="2016-05-11" version="1">MLEPTQSNIVRTEPRQADGIQTPMRSSRKLTSHNLYSITRADAVSLATLSLYLTGVFMSATRLIRLFWLSLTVLALTACGASDKPEDVAQAYYKAAAAANVDAVLKLMYFKETPADQMAQAKGKVNTMINEIAGRARANDGLKKIEVLETSFEKENEAKVKVKVTFGNGKEHTESVELLRNDKKWQVRIWVRMRPEQAEWPSRRGESPEAATPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA0</accession>
    <name>A0A139SQA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711153.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02885"/>
    <dbReference type="EnsemblBacteria" id="KXU36717">
        <property type="protein sequence ID" value="KXU36717"/>
        <property type="gene ID" value="AXK12_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="313" mass="34741" checksum="8A9CB40B1AF9A0CB" modified="2016-05-11" version="1">MTSPASLPIQTADHWQDYQLLDCADGMKREQWGPYSLLRPDPQIIWGRAPLSPPPENAREPLPHAIYHRSDKGGGHWEIRQKLPESWTLAYAPLGLRFKIRPTNFKHTGLFPEQAVNWEWASALIKAALSKNGSAPRPRVLNLFAYTGAATCAAAKAGAEVAHVDAAEGMVKWARENATLSGLAEAPIRYLCDDCLKFVRRENRRGRRYDAIIMDPPSYGRGSGGQMWKLETHLWPLLQECRALLSDTPLFFLINAYTAQLSPTVLANLLGELFAAQPDCTISAGELGLPIQADGKTLPCGIFGRAQWTRTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA3</accession>
    <name>A0A139SQA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711130.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02750"/>
    <dbReference type="EnsemblBacteria" id="KXU36694">
        <property type="protein sequence ID" value="KXU36694"/>
        <property type="gene ID" value="AXK12_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="461" mass="50174" checksum="D3B821AC28A54370" modified="2016-05-11" version="1">MSWVLPILAVALGAAFYALWARREGLLALESYRRGQLSELSATLGNLQEAVLVVDAENRVRLANHALRRIFADAESLVGARLDAERHGQALLDYLDVVRLRQRTPRRRIEFEAKPRFTGEPERGAGPLVGGASPNNRGEPVAQSVWAEVAGTLMPPLGNDAIGQGAWVLVVLHDITQQHKLETMRKDFVANVSHELRTPLSVIMGYVETLVDAHRTIPEETREQFLLKIQRHTQRLNSLLDDLLSLSRLESEAPNAGGAGSVRERVDLAKLISGVVEDYRGRPAVLEGRFRLCSELIDCGPPAATEGTAPSASVLAESGADAGLYVLGDALQLTRALENLIDNALKYTPSGSEICVSARRVAAAVGADEAEPMDARRLASREVVEVRVRDDGPGIPAEDLPHIFERFYRVDKGRSRAQGGTGLGLSIVKHIVQLHGGRVWARARDEVAGQGTAIYFTLPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQC1</accession>
    <name>A0A139SQC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02970"/>
    <dbReference type="EnsemblBacteria" id="KXU36733">
        <property type="protein sequence ID" value="KXU36733"/>
        <property type="gene ID" value="AXK12_02970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="2">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="3">
        <location>
            <begin position="158"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="353" mass="39815" checksum="DEE710EE13080B0B" modified="2016-05-11" version="1">MPPAPRSTAAPAASQLSRPPLERMLKIHAQLRRGARVNGTQLAEQIEVSRKTIVRDIAFMRDRLDLPIAFDPQLNTYRYTHQVEAFPTVNVTEGELLALLVAQRALEQYRGTPFHRQLSIAFEKLTSNLRDQISFSPSEEFHAVSFKNIGTSKTDLTLFNALSTAVQQQEEVQFEYRKPGSAATTHSAEPSSGEKGAEPASLVRHVRPYHLANRENLWYLIGYDLDRQALRTFALPRISALKRARRHFERPADFSPEQFFANALGVLGGAGDWQVRIRFSATVAERVSEREWHDSQELRALPDGTLELSLRLGALEEVEQWVLSWGAHAEVLGPPELRTKMQATAKKLVAIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD3</accession>
    <name>A0A139SQD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711159.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02920"/>
    <dbReference type="EnsemblBacteria" id="KXU36724">
        <property type="protein sequence ID" value="KXU36724"/>
        <property type="gene ID" value="AXK12_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="227" mass="24519" checksum="4858ECE9462B251B" modified="2016-05-11" version="1">MPSKTVIIEDETVFRQMLSLALKKVSGLQLVGEFSDGRSGLDFCLAEKPQLLVVDMYLPEVHGMEIVKEVRAQSPGTRILVLTGHPDGDLPARLLRAGVHGMVDKTAPLSYVLQAVEAVMRGGMFFAASVPPIPNAEDKPEPSFYRMPHTQPPPSAPSLAAAATLTPRELEIVGLVSEGFSSKEVAGQLNLSVRTVEKHRANAMEKLDVHDVASLVRYCIKAGIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQI8</accession>
    <name>A0A139SQI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711156.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36721">
        <property type="protein sequence ID" value="KXU36721"/>
        <property type="gene ID" value="AXK12_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="20904" checksum="3EA68E87FE0D0CBF" modified="2016-05-11" version="1">MLKYQDTILVLRKPNGVTAIQGNVFVNRGGHLDFDTSHQLARSSVVTLNEGELYLGNWGGDITQSFKQLIVDNSGVLYFEGDDGSSSIHKLYLDDLLIHASGELIFKRWKEGRDFILVKKTSENVEDALKKMKFEGYDPSKIQLADYNNEYWEVKGAPEPATYGAGLMLGVLGLVRYRRRQNSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR1</accession>
    <name>A0A139SQR1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ORF">AXK12_02565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711094.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02565"/>
    <dbReference type="EnsemblBacteria" id="KXU36916">
        <property type="protein sequence ID" value="KXU36916"/>
        <property type="gene ID" value="AXK12_02565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="213"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="512" mass="56898" checksum="91995DDE57776B3F" modified="2016-05-11" version="1">MSDSSRHPFLHGLSKHRGAPPTVVVIFGASGDLTARKLIPAVYNLGVDNLLPTDFHLVGYGRKEIPDEEFRSLAVDSIREFSRRALQEEVWDRIAANTTYVAGGYDDLAAFDRLARHIEAIERQVGREVQVLFYISTPPSVFAPILENLGAVGLAQKHLGAAHHAKVIIEKPFGRDLTSAQSLNTTIRSVFREHQVYRIDHYLGKETVQDLLVQRFANAIFEPLWNRNYIDSVQITVAEEVGVGTRGGYYEQSGALRDMIQNHTMQLLALTAMEPPVSLDAEAIRDEKVKLLKAIQPLRLGLGGDVARAQYASGMRDGQPAKGYLEEGGIAPDSNTETYVALRLSINNWRWQGVPFYLRSGKRMARRVSEIAINFKQPPGTLFAGSEQFSLAGNTLAFQIQPDEGLSLILNAKIPGLQTRMQPVKMNFRYATTFGSNTPEAYERLVLDAMVGDGTLFIRGDEAETSWRLCTPLLEHWEASGREGMDSYPSGGWGPPSADALLAENNHRWRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQS4</accession>
    <name>A0A139SQS4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711127.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36887">
        <property type="protein sequence ID" value="KXU36887"/>
        <property type="gene ID" value="AXK12_02700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="271" mass="30973" checksum="2191CCA92E7B94C3" modified="2016-05-11" version="1">MQLNQRLGSPVLAIFSRWLRWLVFGFGVAHLCVAFELIDRPFWVLAVAFMLLWFLIETIYNWLGIQALSVSPLPLFPRYIESPNGEEWPTLPRFLKIREWLRANGFSLVQPVKAEIGGGIHLRSCVYQDQAGGIRLQITFMPLSAATLGVCYSLVSHTAGGQRLVTDNFYIPYAGFYPEHWFVERLPLTRSLAKLVARHRARLAGEAAIPFTSEPVADLNAQQHELDQLNTQLGFLNPHGEREEFGKISQAGRYRIWKEVWMLNYLGRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR74</accession>
    <name>A0A139SR74_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_02335</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711053.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02335"/>
    <dbReference type="EnsemblBacteria" id="KXU37099">
        <property type="protein sequence ID" value="KXU37099"/>
        <property type="gene ID" value="AXK12_02335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="339" mass="36637" checksum="DAB7B0CE16C8D004" modified="2016-05-11" version="1">MTDRAFSLALTQRPRRLRRSASLRALVEETVLRPADFIAPLFVIEGEGPPEEIASLPGVRRLPIHALVSECRELWALGIPAVDLFAKVADSEKDAVGSVALGDESLVARAIRAVKAAVPELTVITDIALDPYTTHGHDGLLTEDGRDVDNDSTVEQLIAMALAHARAGADLVAPSDMMDGRVAAIRAALDAAGFEQVGILAYSAKFASGFYGPFREAVGSSKVGTVAGPADKKTYQLDPANRREAIREALLDEAEGADILMVKPAGLYLDIIRDLRERTHTPIAAYQISGEYAQIHAAAERGWIDYERCRDESLIAIKRAGADMILSYFAKEVARGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS27</accession>
    <name>A0A139SS27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02060"/>
    <dbReference type="EnsemblBacteria" id="KXU37405">
        <property type="protein sequence ID" value="KXU37405"/>
        <property type="gene ID" value="AXK12_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="45"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="251" mass="26759" checksum="C79777598DC7C7F7" modified="2016-05-11" version="1">MLSAFVSSASLMAAIVEKPISYEHSGATLHGLLVYDEAKVGGGERLPGVLVIHQWMGRGEFEAAQARQLAAEGYVAFALDMYGEQPKNTAEARALTAQFYGKALMAERAGAGLDQLLSSDFVDSEKVAAIGYCFGGTTAMALAYSAAPLAGIVSFHGGLIEAPETAPEPLRAKFLICHGAVDPFVPWAQVQATLDSLEAAKIDYQFIAYQGAVHSFTDPAATGEGSPGAKYQREAAERSWAHMIQFFEEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS38</accession>
    <name>A0A139SS38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_02030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02030"/>
    <dbReference type="EnsemblBacteria" id="KXU37415">
        <property type="protein sequence ID" value="KXU37415"/>
        <property type="gene ID" value="AXK12_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="296" mass="33558" checksum="6F9D2DF5CC631BAF" modified="2016-05-11" version="1">MQIYLQEISKTPLLTIQEEIALAERIQKGDIAAREHMIKANLRLVVKIAMDYKDFGLPLLDLISEGNIGLVKAVERFDPAKGGKLSTYAAWWIKQSIKRALANQSKTISLPVHLVDKIAKMRRTAAALNEELGREPTDEEIARELQIPTAKVAHLRSVSVRPASLDAPLGDDSDSSSLGEIIGDENAINPFDSLRNRLQNSDLHEMIASLDQREAEIIRLRFGLEGREPLTLEEVGRHFHVTRERIRQLEYLALNKIRRAMAKHEAIRSADEVEDERRRVQRLQTLRNFAASKTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS67</accession>
    <name>A0A139SS67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ORF">AXK12_01955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710974.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01955"/>
    <dbReference type="EnsemblBacteria" id="KXU37387">
        <property type="protein sequence ID" value="KXU37387"/>
        <property type="gene ID" value="AXK12_01955"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="333" mass="35066" checksum="2B3800253486691B" modified="2016-05-11" version="1">MAKPPTIRIFGTGAHAPSRVLTNAELSAKIETSDEWIVTRSGIRERRVAGPEEGTSDMAAAAARAALADAGVAPSEIDLLILATITPDLSMPASACSVQHKLGLSPTTACFDISAACSGFVYGLDTAAAMLQSGRYKRALLIGSEKLSTIIDWSDRTTCVLFGDGAAAFVLGASDEPDDTAGLIDIKLGAYGDSLDLLYIPKGGSTHPPTAESIAAGDHFIKMKGKELFKLAVRAMAESARDILAKNGLTPDDISLIIPHQANLRIIEAVAKLLQIPLERFFVNVDRYGNTSAASIPIAIDEARRSGRIRSGDVTLLVAFGAGLTYGSALLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS79</accession>
    <name>A0A139SS79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="7" type="ORF">AXK12_01700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01700"/>
    <dbReference type="EnsemblBacteria" id="KXU37436">
        <property type="protein sequence ID" value="KXU37436"/>
        <property type="gene ID" value="AXK12_01700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M_2" evidence="6">
        <location>
            <begin position="221"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="445"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="603" mass="65059" checksum="408DD50437406B80" modified="2016-05-11" version="1">MIAPQLDSRNANTLWASVLVETLYRCGVRQVVISPGSRSTPLAFAFARHATIEAIPVLDERSAAFFALGLARQARSATSRQRVARQVSRPATALVCTSGTAVANYLPAIIEAHESGVPLIVLTADRPPELRDCASGQTIDQQKIFGGFVRFYHELAVPEPRYALLCYLRQTVANACKLASDQHGPVHLNIPFRDPLVPSEDGGEAARVFGEMRESFFEHLHAEQSHSLEVVELKTLTAARGVIVAGPEWGSDPREYAAQVGRLARELGWPVLADGVSPLRHHPVEGAVVVTAYDAILRNDAAARALMPDQVLCLGDWPTSKVLRASVAAWEPEIIQVTSPSRNRDALHGRTRQITAPLASLRVAQMPPTLDYLNAWAKAEASSRRLLDTLTLSAHPPQQEAEILEAAIVPTLARALPEGAVVFVASSMPIRDVESFWPKTERGFEFHFNRGANGIDGTLSAALGVAHNASAALAPTPRPTFLLCGDLSFLHDSNGLLLAQKLGGSLTVILINNHGGGIFEHLPVANYEPPFEAFFATPQEVDFGKLCAAHGVAHCSIATLAELETELGHSPQQGCRVLELNTDRKRSAAHRKALLAQVSASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS95</accession>
    <name>A0A139SS95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgC</name>
        <name evidence="7" type="ORF">AXK12_02045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710988.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02045"/>
    <dbReference type="EnsemblBacteria" id="KXU37402">
        <property type="protein sequence ID" value="KXU37402"/>
        <property type="gene ID" value="AXK12_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="431" mass="47092" checksum="FAF3B45BF704597F" modified="2016-05-11" version="1">MTTRKRVLAVIMGGGRGTRLQPLTAERCKPAVPLAGKYRLVDIPISNCINSEINRMFLLTQFNTASLHRHIRETYHFDAFGGGFVEVLAAEQTEKSVDWYQGTADAVRRNLNHFRVFDHDLVLILSGDQLYKMDFRELIDAHIASGADVTLSAIPVPVSKVEGLGLMKVNDALEIEDFAEKPSDPAVIEGLALSPKIEKRLHAPTIGREKHCLASMGIYLFNRKALTEALDNTMADFGKEVIPSLRGRKKLCAHIFEGYWEDIGTVKAFYEANLALAQPLPPFNFFDPRAPVYTLDRYLPPSKINLCTVDNIVVGDGSILSNGVLTHCVFGLRSFVADGCALEDVVLMGADFYETPDDQAENKRLGRPNIGVGKNCTIRGAIIDKNARVGDGCTLDATGKADGRYAAGAVIVRDGVLVVPRGGIVPPNTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSE3</accession>
    <name>A0A139SSE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37381">
        <property type="protein sequence ID" value="KXU37381"/>
        <property type="gene ID" value="AXK12_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="247" mass="27575" checksum="6D50183CD20F3BEE" modified="2016-05-11" version="1">MYLPAEDRIPLLAAFMKTPPNNTPPAAPEPWPMKWIVLALLPCLAAYTFVTLQYRKPGHAFEPYNDLKARAQIHQLLEAGFQRIPLEIRDATDSRPLNKEPDFPDYAENPANKRTLYALITRTAEGGLPENLAAALIEPPHLIRETSTSLGPADLHEGGDFVLKARFYASAEPVAAQLYVHGNQIFLVVELAGPDAPEDDFDAEHVEYRKWLIAPKVPLKPGRYTGLLIGAEESMLWGLKVYEAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSG2</accession>
    <name>A0A139SSG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">AXK12_02040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710987.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02040"/>
    <dbReference type="EnsemblBacteria" id="KXU37401">
        <property type="protein sequence ID" value="KXU37401"/>
        <property type="gene ID" value="AXK12_02040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="324"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="496"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="647" mass="69610" checksum="7F1DEAFCB14E6CEF" modified="2016-05-11" version="1">MCGIVGYTGKQHATPFIIEGLKRLEYRGYDSAGLAVTTAATGSEPGEPDSAKARAPSAAKLHYLKRIGRVAELELAAAQQHSALPALAHCGIGHTRWATHGGVTEANAHPHLSNDHRIALVHNGVIENFHSIKTFLLGHGYTFASETDTEVLCNLIAYHYAKTPPQNAHNANDAQDARLLVAVRGALRHVEGTYGLVALCVDAPDELVAARKGSPLILGIGEGEHLVASDAAALISRTQKVVYLNDGELAHLSPTDLRLSSLNAAPLEPVVDQITWSIAQAELGDYAHFMQKEIFEQPDALENTMRGRFSEDGSTAQFGGLNLNADELRNVDRIILCACGTAWHACLVTKHLIERFARLPVEVDYASEFRYRNAPLSPTNTLCLVMSQSGETIDTLAALREAKRKGLRVLAVTNVVGSTIAREADGGIYQHAGPEIGVASTKAFTSQLLIGAMLALYLARLRTMSFTDGAAAVAALRAVPALIRKTLEQAPRIAEIATRYAQVTDMLFLGRLALFPIALEGALKLKEISYIHAEGYPAAELKHGPIALISPDCPSVFFVTRGELFSKVVSSMQEVKARGGPIIAICTEGLELPEKLADARIDIPDCHEAILPLVATIPVQLLSYEIAKQRGCDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSH2</accession>
    <name>A0A139SSH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710920.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01645"/>
    <dbReference type="EnsemblBacteria" id="KXU37513">
        <property type="protein sequence ID" value="KXU37513"/>
        <property type="gene ID" value="AXK12_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="337" mass="37197" checksum="7AD62E990AC2AA18" modified="2016-05-11" version="1">MSTCTSRPSRLSRLLFQPATAPLPALTHIADFLAEFRTVAASLQNNGRSASLGGGASALGGKLETIGEVSGHPLFAWTRRVPAHSWYPAETGDPHLTPPLHQSGRRQGLKPTRPMPSSARRQDARQIKQPAIPKIYLSAGVHGDEPAGPLALLELLAEGFFDDRAHWFICPVLNPLGFVKGTRENADGIDLNRDYLACHSAEVRAHIAWLQSQPPFDLTFCLHEDWESTGFYLYEHNPKGRPSLAPALLDAARPHMPIEPAHIIDERPIDEPGILRPEIKAQDRDDWPEQLYLREHFHYDLGYTMETPSSLPLAPRIAAQKALVATAVEGLLKELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SST7</accession>
    <name>A0A139SST7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="8" type="ORF">AXK12_01415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710878.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01415"/>
    <dbReference type="EnsemblBacteria" id="KXU37626">
        <property type="protein sequence ID" value="KXU37626"/>
        <property type="gene ID" value="AXK12_01415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="358"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="488"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="510" mass="56215" checksum="3332B1FB36C06BC1" modified="2016-05-11" version="1">MSSSLFSSRLIADVGISFGDEGKGRLIPEVADELRGTPAQVSVVLKVNGGANSGHTAGGIKLNLLPAGVVVPDVAHLCMGAGVVADPRKIWWEARPLEHKGYAILSRLRIDERTMVSDLSHRLLDLATEHYRTHTLGEEPRGSTGRGITPAYQEEVGQWQITYSDFLAGPNYFARKLAQRAQRALDTIRHVYRVDAASFAAFFDTLTAAETRANEEALALGLFTPDEFDFTRFRGTEAFTLKLDELTRVYWEAGTALAANIGEVRELILREQSAGRSVIGEFGQAYWLDKRHGYSPNVTASHTYVPEFFESAGIPLQALHTIAVAKAYDTKVGTHTFITQMDDAHPLAARLKKLEFGTSTGRQRMVGWYDAVEKGDALRYGGFADLMINKIDALTGADELLICTAYEDANGRRYAHVPRNEAIRKTLRPVYTRYPGWAEDISQVRHFAQLPANAQRYTAAMLRALIDVAYEGVARPADAALPRLRYLGVGPEPSQIIKDLPPTAELVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSY1</accession>
    <name>A0A139SSY1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HemS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710896.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01520"/>
    <dbReference type="EnsemblBacteria" id="KXU37644">
        <property type="protein sequence ID" value="KXU37644"/>
        <property type="gene ID" value="AXK12_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007845">
        <property type="entry name" value="HemS/ChuX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010413">
        <property type="entry name" value="HutX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06228">
        <property type="entry name" value="ChuX_HutX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05171">
        <property type="entry name" value="HemS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299413" description="HemS domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="HemS" evidence="2">
        <location>
            <begin position="285"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="422" mass="45940" checksum="3D60A3BBEA73A332" modified="2016-05-11" version="1">MTRSRHLFAALASLSAAALLLTACNTTDTTGAPSQVASTAGTSDAIAPAQTSLDLPAASTLSAGTRSTAEKIGHLQTVGRHERVREATRLGLSEAHLFAADVGKNVIRLKDGRETALEILNRRLHELGRLRASARNDDVSLSVIGTPRPPRLIPATEEREARTFPGYFGPPIDLRPDFSNWQFTFAQITFTRDGQVQRSLTFFDNQGRAVQRLIIDTLDGIPAFEQIIQDFRAETQSSEIVLTPEEPADPIRPDAQVDVPSLIAAWDAITDVHQFSTAVLAKHDVTRLQALRLAGPERAQRLDSPKALNALLSAAAHEKLEIMAFVSNSANTQIFTGKIEAPTKARGGWLRVGDEHGASLSINEAGIDQIWLVKKPSSIGILSTVEVYNAKGEVIVQFYSKREPRKPESDTWRALLAKLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST37</accession>
    <name>A0A139ST37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710894.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01510"/>
    <dbReference type="EnsemblBacteria" id="KXU37642">
        <property type="protein sequence ID" value="KXU37642"/>
        <property type="gene ID" value="AXK12_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299415" evidence="1">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="225" mass="24411" checksum="44C41DEFC996330D" modified="2016-05-11" version="1">MNKLPLLLALALFALAPISLSRAHSVWIEDNDAQQLVVRFGQVGESYESSPGYLDDLHLNSAWTADADGKLAPLSIEKKSDHYLLDGAAPDQATLGETTFYVMQHGKSPAIWPILYVRWQPTTAEIPAEPALTLDLLPTGTPGEIRVTFRGKPLPGAIVSIASEEDADHKTPKLTANAEGIITYTPQSPGLVVLTANHREALPGFTRGKAYELISHTGAISWRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB2</accession>
    <name>A0A139STB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710845.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01260"/>
    <dbReference type="EnsemblBacteria" id="KXU37819">
        <property type="protein sequence ID" value="KXU37819"/>
        <property type="gene ID" value="AXK12_01260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="20457" checksum="CA7F32DD38F63BB1" modified="2016-05-11" version="1">MSSAVDASPAPSPSALPATALPYKIAVLVFLENVHGEHLLLLRAKPPNFGIWSPIGGKLETALGESPFECAVRETREETGFEIAVSDLHLFAMIAEKAYEGETHWLMFLFRCKRPILALPDAISEGRFGFFSREAIDSLPVPETDRQALWPIYDRYREGFVALRADCAPGEPIRVEVEQITGTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN4</accession>
    <name>A0A139STN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">AXK12_01195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710871.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01195"/>
    <dbReference type="EnsemblBacteria" id="KXU37842">
        <property type="protein sequence ID" value="KXU37842"/>
        <property type="gene ID" value="AXK12_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="315" mass="33310" checksum="D56568F7D9ADE0D1" modified="2016-05-11" version="1">MGSDPIALPLLNWLWESTEGPAVAQIVGVFTQPDRPVGRGQKITANAIKQWALARGLPVYQPETLDTFALDTLASLRADLSLVMAYGHILRDEFIAAPRLGTLNLHASILPAYRGASPIQMAVANGETETGLSLMRIVRELDAGAVADVERVPIAPLDTALEVEAKLAAACVPLLARNLPKLARGELVFHEQDHARATFCRRLEKSDGVLDFTRPAAELAARINGLFPWPACSFQVGEKSIKCGLADVAPSAVASVAAHATGPGTVLGADAEGLLISTGEGILRVRRLQRPGGQMLPAADFLRGNPILAGTVCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN9</accession>
    <name>A0A139STN9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">AXK12_00860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710772.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00860"/>
    <dbReference type="EnsemblBacteria" id="KXU37943">
        <property type="protein sequence ID" value="KXU37943"/>
        <property type="gene ID" value="AXK12_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="129" mass="14457" checksum="22B467E36542AF76" modified="2016-05-11" version="1">MARATNSPASRKRRKKVLKYAKGYFGNKSRLFRYANDAVKHAWQHAYIARRKKKSDMRALWIVRLNAACREAGISYSRFMEGLKAAQIELDRRVLSNLAIEDAAAFAQLVKQAQDALKAKAASTAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP0</accession>
    <name>A0A139STP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">AXK12_01160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01160"/>
    <dbReference type="EnsemblBacteria" id="KXU37801">
        <property type="protein sequence ID" value="KXU37801"/>
        <property type="gene ID" value="AXK12_01160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="23531" checksum="DBC27DF37859CB1D" modified="2016-05-11" version="1">MCGLTSLRDARYAEQCGADYLGFILHRRSPRFVSPERFFEMRPALPPQKKVAVVVEPDEELLGEMLEAGFDFFQVHFRHTVEPALLRHWSTALRGERLWLAPKLPPGEDVPEAWFPLCAAVMLDTFSPDKFGGTGEVGDWAKFARHRVRYPTQQWILAGGLGPDNIGEAVRASGARFVDVNSGVEAAPGVKDLRKLERFTAELARARAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STZ9</accession>
    <name>A0A139STZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38053">
        <property type="protein sequence ID" value="KXU38053"/>
        <property type="gene ID" value="AXK12_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU38053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="533" mass="57496" checksum="BC020C4EAD900A35" modified="2016-05-11" version="1">MLEEDADDFFGEVVISGAQLTLKGEGRLTEAERFLIQNGGTLFLDNSAVAHDDRLGSTADIALNAGTLAFDPGNFGFLSQELGYIDLLGGANQIDLYLGSVLGGRLFAETVWLADNAQIGKPTSTLNIRYIDPTGIAPINVRLEVDDDWGFPSIEGILPWATITRGSQVDWVQWEYGESTVFTPLTAYHTSTGSPADWNTGKDMLIEASTAELNDPGILNPQITSLKLANGGSLVLGEPGDLKIISGGLLSTGSTGNKISGRGSIWNGYDIPNTFYLHIHADLLVSGEIQFHAFGFPMIKTGEGTLRFTDDASIAVGSLVINQGIVAFEKNTRMELFEVIIGDGTGTDILELPASHNDPITNPSAEWDPGALPNITLHGTPYSTSPGSGAADAAILRFGGSTVQHAQLLHVEGRGTLDFVGGTIAKPNMLYLEEFTLADFDTALLFIRHWEDGRDVLLAHYENNKGTINAAFLARIKFEGYDAPAEWVSWGDGTYWEIRVAPEPHTYGAILGALGLGLFVWRKRKRGERAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU26</accession>
    <name>A0A139SU26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">AXK12_00895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710813.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00895"/>
    <dbReference type="EnsemblBacteria" id="KXU37982">
        <property type="protein sequence ID" value="KXU37982"/>
        <property type="gene ID" value="AXK12_00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="416" mass="45756" checksum="7F69074517931800" modified="2016-05-11" version="1">MSREILFVLEYMEKEKGIGRADMINTIANAVKTAAQKGVNSGQELKIEINERNGQMHAWALLKVVDSVSDPKTEIHVERAQAIQPGAQLGDIVELEIDPSTLGRIAAQTARQAVMQRLRQFEKERIYDDFKDQVGNIVTGTVRRRERGDLYIDLGKAEAVLRSREQVPGEEYQPDERIRCLLLGIDSTPRGPEIILSRASPRFVRRLFELEVTEIADGTVKIEAFAREPGYRTKIAVTSTDPRVDPVGACVGARGARVKTIVRELGGEKVDIIKYFSDPREMVLEAFKPAVPREIIINEVDHRILLKVATDDLAVAIGRKGQNARLTSRLIGWRLDIEEFKAAGDDPVRSAIDLLVATFGIDASSASRLVEMGINSPGAFEGVDAEDLIDAGFSADEAQTIIARVSASTAEASAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU32</accession>
    <name>A0A139SU32_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">AXK12_01025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710801.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01025"/>
    <dbReference type="EnsemblBacteria" id="KXU37970">
        <property type="protein sequence ID" value="KXU37970"/>
        <property type="gene ID" value="AXK12_01025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="238"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="267"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="481" mass="52903" checksum="223E8B081AD846B0" modified="2016-05-11" version="1">MASAPSPLKNAPKGQDYIVRDLSLAAWGRKELNIAEHEMPGLIALRKKFGAKKPLKGVRITGSLHMTIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWELTWRALSFPGDKGPQLIVDDGGDATLLLHKGYEMEQGSDWVNTASESEEEEVIKKLLKKIGRTQKGIFAKRVSEWRGVSEETTTGVHRLYQLHEKGQLLVPAINVNDSVTKSKFDNLYGCRESLADGLKRATDVMIAGKVACVCGYGDVGKGSAHSLRGFGARVIVTEIDPINALQAAMEGFEVNTIESTLGQADIYVTTTGNKDVITLEHMRRMKDQAIVCNIGHFDNEIQGARLAAAKDVTHVNIKPQYDQYTFGKNGPTIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIDLWQNKDKYAPGVYRLPKHLDEEVARLHLDKIGAKLTRLTKEQADYLGVPVGGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU89</accession>
    <name>A0A139SU89_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">AXK12_00655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710739.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00655"/>
    <dbReference type="EnsemblBacteria" id="KXU38052">
        <property type="protein sequence ID" value="KXU38052"/>
        <property type="gene ID" value="AXK12_00655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU38052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="498" mass="53739" checksum="D4DE02201F2C208F" modified="2016-05-11" version="1">MSEKVILALDQGTTSSRAILFDRRGENRGLAQKDFRQLFPQPGWVEHDPREIWESQIGVARELVAKAAAEGLEVAGLGITNQRETTLVWERASGAPIYNAIVWQDRRTAGDCDALRAAGHVDTIRQKTGLVVDAYFAATKLKWILDHVPDARARAERGELCFGTVDTWLVWNLTGGARFITDASNASRTMLFNIHTLDWDEDLLALFEIPRAMLAEVRESSEVYGTTAANIFPSPVPIAGIAGDQHAALFGQLCLSPGMVKNTYGTGCFLMMNTGAQPVLSENKLLTTIAWTLGGEVSYALEGSVFIGGAAIQWLRDGLGIIDRAEEVNALAASVADSGGVVFVPALTGLAAPHWDAYARGTILGITRGTTAGHIARATLEGIALQVCDIVKAMEADAGARCAELRVDGGASASDLLMQIQCDLLGFKTKRPKTLETTALGAAYLAGLALGLWSGVAEIQTQWSVERDFVPQMLREQADTISRTWQKAVARSRDWVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH72</accession>
    <name>A0A139SH72_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_08395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713364.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08395"/>
    <dbReference type="EnsemblBacteria" id="KXU33915">
        <property type="protein sequence ID" value="KXU33915"/>
        <property type="gene ID" value="AXK12_08395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="270" mass="30665" checksum="41087E40ECA09B15" modified="2016-05-11" version="1">MLRIFCPNFITDLWRHRELLWQFTRRNIELRHRGSHLGLVWSFLNPLLMLGLYVMVFGYIFSGKFGVMESETRIDYGLGIFLGLTLFHFISETLGTAPNVILGNPNFVKKVVFPLEVLPAANVGSAAFHLVISLSLTLIGTIWLGPGLHLGLLWLPVILLPLFLMALGISWLLSAVGTFFRDVAQVIGFINMVLLWTSGVFFTAHKYAEAWTWLRYNPLLLAIDLARNAVLWEHPLVTAHLLYVYAWGAGLCLFGYWIFKKTKPIFADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH73</accession>
    <name>A0A139SH73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="6" type="ORF">AXK12_08410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713370.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08410"/>
    <dbReference type="EnsemblBacteria" id="KXU33918">
        <property type="protein sequence ID" value="KXU33918"/>
        <property type="gene ID" value="AXK12_08410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU33918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="328" mass="37082" checksum="2722D2D79C243CEC" modified="2016-05-11" version="1">MAKKALITGITGQDGSYLAEFLLEKGYEVHGLVRRASTLNRARIDHLQGFEHGENPRLILHYGDLADSVSLVKLLYSLQPDEIYNLAAQSHVRVSFDIPEYTSDVTGVGAGRILEAIIESGIGKKVRFYQASSSEMFGKVQAVPQTETTPFYPRSPYGCAKVFAHWLTVNYRESYNLFACSGILFNHESPRRGESFVTRKISIAAARIKKGLQKELYLGNLDAKRDWGYAKEYVEGMWLMLQQDKPDDYVLATNETHTIEDFLSAAFGHLDLDWRDYVKFDSRYLRPAEVDLLIGDYSKAKRALGWEPQTRMHGLAKLMVDADLAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF1</accession>
    <name>A0A139SHF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_08135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713258.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08135"/>
    <dbReference type="EnsemblBacteria" id="KXU33995">
        <property type="protein sequence ID" value="KXU33995"/>
        <property type="gene ID" value="AXK12_08135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="265"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="407" mass="43248" checksum="0E00F541A49851DD" modified="2016-05-11" version="1">MPRIVQKYGGTSVGDVERIKKVAERIKATRERSGSVVAVVSARAGVTNELLARARSVSEQPPRERELDQLLAVGEQETCALMAMALHGLGLEAVSYTGAQAGIRTDNVHTRAKIRMIDPAAIERDLAAGRVVIVAGFQGINDHGHTTTFGRGASDLSAIALAAALKADKCEIYTDVDGVYTADPRVVPDARKLDEIAYDEMLELASSGSKVMMSRSVELAKKYNVIFEVRSSFNYNPGTIVKEEVAYMEKVVVRGVAVDKDQAKVIVSNIPDKPGTAASVFRALADANVNVDMIVQNVGRGGVANLTFTVPQGDSHRAVETLQPVLAELGGGEVSIQDHIAKLSVVGVGMRSHSGVAATLFQTLAAAGINIEMISTSEIKISIVLDQLRADDAARLAHAAFHLDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI7</accession>
    <name>A0A139SHI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713231.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08055"/>
    <dbReference type="EnsemblBacteria" id="KXU33981">
        <property type="protein sequence ID" value="KXU33981"/>
        <property type="gene ID" value="AXK12_08055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="31069" checksum="64F03A086D883001" modified="2016-05-11" version="1">MEPPPNIDATWWRRLPLGRGVELIAHDANGVAALYKPTGLLSHPNAAGDEARALLRATYDFKEECYELGSLAVTDKRRDADERPARKENLWLLNRLDSATSGLLLVCANRELALKIRQRFRERAVHKVYAALVFGKLGQSLRGGAQPVVWRDRLSIEKRGGQIRTKASARGSAGVSAETRVKVLRVGQGVSLLQLEPLTGRSHQLRVQCARRGLPIVGDATYGDFAANRLFSKAHTGTRGRLFLHSLETRFDYEWRGRTVRFAARAPLPEEFARLVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI9</accession>
    <name>A0A139SHI9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ORF">AXK12_08285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713305.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08285"/>
    <dbReference type="EnsemblBacteria" id="KXU34017">
        <property type="protein sequence ID" value="KXU34017"/>
        <property type="gene ID" value="AXK12_08285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="86" mass="9565" checksum="59BD2AFD9845AB67" modified="2016-05-11" version="1">MADHKTIEQRVKEIIVKQLNVNEEQVTPSASFLDDLGADSLDTVELIMAFEEEFREEIKGEIPEADAEKLQTVGQVSDYIKAKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM8</accession>
    <name>A0A139SHM8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">folD</name>
        <name evidence="12" type="ORF">AXK12_08310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713313.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08310"/>
    <dbReference type="EnsemblBacteria" id="KXU34021">
        <property type="protein sequence ID" value="KXU34021"/>
        <property type="gene ID" value="AXK12_08310"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="10">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="11">
        <location>
            <begin position="143"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="314" mass="32838" checksum="29C562AA711603BD" modified="2016-05-11" version="1">MSSKLIDGNEIAAAIIAELKAEVATLAKAQATSSRDEPAASGPHDKRAQHLPTLALVRVGDDPASVSYVRKKEKTAAEIGIASRVILPPITTTQAELEALIDELNADDSVDGILVQSPLPAPLDELRIFRRIAPEKDVDGLGTMNLGKVAQDDDTGFVSCTPAGIMALLARSGVDLRGKHVVVVGRSLLVGKPVALLALQKKAGANGTVTICHSGTADLPALTRQADVLIAAIGRPEFITRDMVKPGAVVIDVGINRVEDPTRKTGYRLTGDVAFAQVAEIASLITPVPGGVGPMTVAMLMSNTLKAYRQRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI34</accession>
    <name>A0A139SI34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor Soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713156.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07860"/>
    <dbReference type="EnsemblBacteria" id="KXU34181">
        <property type="protein sequence ID" value="KXU34181"/>
        <property type="gene ID" value="AXK12_07860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="266" mass="28474" checksum="DF6AE515D4B95AF3" modified="2016-05-11" version="1">MPTTSPPSRTTVFTIANQKGGVGKTTTAVNLAAALAAQEIPTLLIDLDPQANATSALGLEKTEGRSLYGPLRGEGEAAEMLTPTAIDGLTIIPSEEDLAAAEIEIAQSENYLSLLSRVLAPIRASGDYRAILIDCPPALGMLSMNSLCAADSLLITLQCEYMALEGLGQILRNVERLKTANINPDLQLGGIVMTMFDARTNLSRQVVEEVKAHLPDKIFKTLIPRSVRLSEAPSFGQTIFDYDPQSAGSLAYRALGEEVITRFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID2</accession>
    <name>A0A139SID2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713103.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07480"/>
    <dbReference type="EnsemblBacteria" id="KXU34309">
        <property type="protein sequence ID" value="KXU34309"/>
        <property type="gene ID" value="AXK12_07480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="304" mass="33140" checksum="BB902C7C4674C075" modified="2016-05-11" version="1">MLLKYQFDYDLRHLTSFFAVAQLLHFSRAAELLGIAQPALSRQIAHLEEALGTALFARTRRSVELTAAGHALFERLQPLLGALQRLPTELAAVSAGEVGQVRIGFTGLAMATVLPKILRAFAQTHPAIRVELSESPTAAQIDALRSGEIDCGFFHPAQEKPEGIRTRQLLREPNGVLLPVTHPLAKKKMLHLGELGDTPFVLFPRHLNPSFYDRILTSCTRAGITLKIADEIWPRANAIGLVRAGLGATFITPSEAQTLPGDIVFRPLEGPSPESRLVAGWCLNASQSPPAQAFLHLVANLHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID3</accession>
    <name>A0A139SID3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_07470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713015.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07470"/>
    <dbReference type="EnsemblBacteria" id="KXU34307">
        <property type="protein sequence ID" value="KXU34307"/>
        <property type="gene ID" value="AXK12_07470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="325"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="621" mass="66481" checksum="493B91707D78337A" modified="2016-05-11" version="1">MNTQLLIVLVLLCACIGLFIINKPRMDVVALCVIILLPLCGIMSVQEALLGFSDTNVVLIGALFIVGEGLSRTGISFRVGDWLLRRAGNSETRLVVLLIVAVVVLGSMISSTGIVAIFIPVVLSCASRMRVPPSRLMMTLSFAALISGMQTLVSTPPNMMVDSALRREGFEGLKFFSYTPIGLVVLVLGVGYMLVARHWLNGTDKAAGDDDGQPAGDGALVGSSQRRLQDFITDYQLEGRAHRARVKIHSPLVGLKLRELTLRQDYGANIVAVERRGRFSDELREPNSGLELRDGDVLLIDLFREGADIAALCRAMSLEPLAMPEGYFTDESRAIGMAEVLLPPDSGIIGKTVPEAALRRRYGLNVVGLRRGRKALGPVALDQPFHAGDTLLVIGSWKAIRRLQRRLEDFLVLTMPAESEVVAPALSRAPYALLSLAVMVGLMVTGIVPNVIAALLACLLMGVFRCVDLTSAYKSIHWPSLVLIAGMIPFALALERTGGVDIAVNGLVNALGDSGPRVLLGGLFFVTVATTLFISNTATAVLMAPVAVTLATRLEVSPLPFAITVALAASTAFSTPVASPVNMLVLGPGGYRFIDFVKVGLPFSIVVLLVCMLLVPLFFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE9</accession>
    <name>A0A139SIE9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713053.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34327">
        <property type="protein sequence ID" value="KXU34327"/>
        <property type="gene ID" value="AXK12_07580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="226"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="436" mass="47674" checksum="572A290798262ACC" modified="2016-05-11" version="1">MPPTKEDAFSRKQYWIALATPIVIALPPLLVLCLIWGEGYLAFIYYFAWAALACCAPAAALSYTTLRMIQRMGKEAMKSREALLSGFEQVERILPRNTMISAVLLLLGGGSAVITIAPFIGGRGFFYCVGVVIILVPMGLWSLFRHVYPMLRRPLPDGAGRVTGRAITREQAPKVWELVEQVSTRARVVMPDNIIIGLDASFYATESALYLSGATQPVTGRSLFLSVPYMAFMSRDELAVVIGHELAHFTGADTEYTLKFARIYARAHQHYEAMDLDENENDSRKGPPWLTAPARALVAYFLSNFDLAVQHWSRDREFLADAVGAAAAPSPAAAAIALMRTTTLAHVIEPVLHTFAYNGGRSSHPGGLLASVLEAVAQAPELDPLKHLEESQPHPRESHPPTQQRIEALGVALNADLVLSASSREPSGLLEELGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH1</accession>
    <name>A0A139SIH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713041.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34321">
        <property type="protein sequence ID" value="KXU34321"/>
        <property type="gene ID" value="AXK12_07545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="200" mass="22390" checksum="B87D4C2B1DAA37DE" modified="2016-05-11" version="1">MLYALVMTALTVAYRLVAATALEIPNFSPVMALAFCGAIYLREKWLWAVPFVALILSDLWLNHYYLAQYDYGWALKELLLRYGCYGAALGLGWLVSRRKSWSAIFGGALAASFVFYLVTNTAAWAVDKTYAQTLAGWWQAMTIGHPEYPSTIFFFKNSLISDLSFTTLFAVVMEYAALRAGKPSLLTPANPHPPKLHYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH7</accession>
    <name>A0A139SIH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-glucosidase/alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713097.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07710"/>
    <dbReference type="EnsemblBacteria" id="KXU34349">
        <property type="protein sequence ID" value="KXU34349"/>
        <property type="gene ID" value="AXK12_07710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="8">
        <location>
            <begin position="201"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="496" mass="54542" checksum="CB2C515B6A14FFE9" modified="2016-05-11" version="1">MAPQKISPLKIAFVGAGSIGFTRKLLADLLTVPEFANVEFSFTDINKRNLDMVAEICRRDIAANGLKAKVSATLNRRTALRGANYVFCVVRVGGIEAFTHDIEIPLKYGIDQCVGDTLCAGGIMYGQRGIAVLLDICKDIREVAAPNCLLLNYANPMAMMTWAATVYGGVRCVGLCHGIQHGMLGIAAAIGASAKDLDVICIGINHQTWYTQVKHNGVDVPMDKILAGFENDPEASRDEKVRIDMMRRFGYFSTESNGHLSEYLPWYRKRPAEIKNWISNTDWITGETGGYLRVVTEGRHWFEEEFGEGRLPTTVEFTAENRSSEHGSYILEAMETGRVYRGFFNLANRNTISNLPADAIIEAPGFVDRFGFNMPQFGDLPLGCAAVCNASISVQRMGAMAAATGDITLLRQAMLMDPLVGAVCNPPEVWQLVDEMLVAQAEWLPQYSEAIKGAKARLAKGPLIKTKANNKGAARKKIRTTAEIRAQEKKNPREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SII2</accession>
    <name>A0A139SII2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_07360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07360"/>
    <dbReference type="EnsemblBacteria" id="KXU34290">
        <property type="protein sequence ID" value="KXU34290"/>
        <property type="gene ID" value="AXK12_07360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00382"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="210" mass="23089" checksum="23ED97380202C62D" modified="2016-05-11" version="1">MKELGAVCVVVLSVRFNLPNILTISRVPALFAIVALMYGDFRWGATFAFWLFVAAAFSDWLDGKLARSGGQVSTFGRFMDAVIDKVMVVGLMVALVNGGYFVQWRTTAMVLLLCVIGREFIISGLRMVAASKGVVVEADAGGKLKTFMQLNAIGWLLAWRMLAHNFIPEPHGLGLQVVHTIGLLFFAASVLLALTSGWSYWRKHGYVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIJ3</accession>
    <name>A0A139SIJ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_07550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07550"/>
    <dbReference type="EnsemblBacteria" id="KXU34353">
        <property type="protein sequence ID" value="KXU34353"/>
        <property type="gene ID" value="AXK12_07550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="301" mass="33503" checksum="1A738B8784DBA858" modified="2016-05-11" version="1">MLAIDLGVFQRKAHEVKMKEALGWCAVWVTLALAFNGLIWWWRGAAAAQEFLAAYLIELSLSIDNVFVFILVFTSFKVATRYQHRVLFWGIVGAVVMRAVFILVGVSIIARFHWVLYLFGAFLIYTGIKMALPSKAEADVNPEHSFTVKLFRRFFPISDKPHDGQFFIKEKRSEEAGGSRKLRRVATSLFVVLIVIETSDLVFALDSLPAVLAITRDGFIALTSNVFAILGLRSLYFALNGIMELFRYLKVGLALVLCFIGVKMLIEMADIHIGIGASLTVIASVLGTAIVASLLIPERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP8</accession>
    <name>A0A139SIP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-3-oxopropionate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07405"/>
    <dbReference type="EnsemblBacteria" id="KXU34350">
        <property type="protein sequence ID" value="KXU34350"/>
        <property type="gene ID" value="AXK12_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="29878" checksum="E005907648354178" modified="2016-05-11" version="1">MGGNMARRLVDCGYAVTAVYDAHSENATALAKEIGAKHAETLAEVTAAADIIFTVVTDDAAQLSLFDEAGNNTDTLLTSAQGKLFINCATISPKTHVEVERRAQAAGAATLEACMASSIPQARQGTLYLMCAGAETDFARAEPILKTLSSSLRYIGRTGQAAQVKALVNMVMNINTAGLAEGLGLGEALGLDLDMLREVFSQTGAASHVLKTDGEDMQRRDHECYFSAAHAAKDSGIAWTLGVEAGLPLPLASAAKQQYERLVARGLGGLDKSGVAEITFKGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIX9</accession>
    <name>A0A139SIX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">AXK12_07205</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712827.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07205"/>
    <dbReference type="EnsemblBacteria" id="KXU34532">
        <property type="protein sequence ID" value="KXU34532"/>
        <property type="gene ID" value="AXK12_07205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="228" mass="25046" checksum="38B9B4369F1C70D9" modified="2016-05-11" version="1">MRIDVLTLFPGMLDGFLSESIIGRARERGHLEIGVHNIRDWATDKHRTTDDRPLGGGAGMVMKCEPVFAAIEAVQSPGCRRIYLTPDGAPFSSARAEALSRESHLVFLSGHYEGIDQRIRDTVIDEELSIGDYVLTNGTLAAAVIIDALARFIPGVLGEEKSLTHESFTACLLDFPQYTRPATYRGMAVPEVLLSGNHTAIGKWRRAEQERKTALLRPDLLNSSNTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ09</accession>
    <name>A0A139SJ09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712835.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07230"/>
    <dbReference type="EnsemblBacteria" id="KXU34537">
        <property type="protein sequence ID" value="KXU34537"/>
        <property type="gene ID" value="AXK12_07230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299312" evidence="3">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="463" mass="49392" checksum="70FE6C619082235B" modified="2016-05-11" version="1">MLSRFSILCAVTALFASLALAQPSPPSGQSTASLATPTLTLPDALRYAIEHNPAIAQARERIREQQGVVLEVRAQQIPNLALSGDISANDRDLSAGSPAQNRNWGMGVVASQLLYSGGGALASSRSARLAVQAAELELQAIVNEALLSVRTLFYGALLAKEQVAVQEENLKLLEEQLKDVQSRFAAGSVSNFEVLRAQVALANGQPDLITARNDYRLAIEELRRALGVPRAATSALASAATPAQAATSLPPLAGELALEGTPAQTVDEASLMASLSAARANRPELQRLSKLAQAGENQVVAARSGYLPRLSAFGRYDWQRGGPSTGWSDRRDGWTAGLQTQWAVFDGRATAGRSAQAKSRLVQTRLALEETELAIDVEVRRAHSSLTEASELVSASAKVVEQADEALRLARVRYAAGTATQLDVLTSQVELTRARLNQWQSVYRYNVALAALRQATGTPDPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ10</accession>
    <name>A0A139SJ10_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712840.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34539">
        <property type="protein sequence ID" value="KXU34539"/>
        <property type="gene ID" value="AXK12_07245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="153" mass="16924" checksum="F6158AEE269142C1" modified="2016-05-11" version="1">MKNDTQAFANQLLITTLVMIVLTGSIGMGTVWMRHQISTTANHTKVLHARLTETERLINSTRADVERAQDPAMLKLLNAQWRLGLVPPDPQKTATLDEMPVPYLAAKHNRELFGSDGDDAYFRADAGDVSRSSRPVPQATTVSFRGVPVRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJG9</accession>
    <name>A0A139SJG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">AXK12_07035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712764.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07035"/>
    <dbReference type="EnsemblBacteria" id="KXU34689">
        <property type="protein sequence ID" value="KXU34689"/>
        <property type="gene ID" value="AXK12_07035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="89" mass="10583" checksum="525F88459AD9FC26" modified="2016-05-11" version="1">MSTTTVSKPEIIAEYKIHDKDTGSSEVQIALLTARINHLTEHLRTHRKDFHSRRGLLQMAARRRKLLDYVKRHNLAKYTELLQRLHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ0</accession>
    <name>A0A139SJQ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">AXK12_06800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712678.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06800"/>
    <dbReference type="EnsemblBacteria" id="KXU34792">
        <property type="protein sequence ID" value="KXU34792"/>
        <property type="gene ID" value="AXK12_06800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="137" mass="15186" checksum="4970C8F2E4FCB1F8" modified="2016-05-11" version="1">MALAPARTKYRKSQKGRNTGNAKRGNTLAFGEFGLQSLTRGPMTGRQIEAARVTITRHLKRKGKLWIRVFPHKPVTSKPAEVRMGKGKGSVDHYVAVIKPGTMLFELSGVPATIAKEAFRLADAKLPFHCRFLTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJU7</accession>
    <name>A0A139SJU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="11" type="ORF">AXK12_06860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712700.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06860"/>
    <dbReference type="EnsemblBacteria" id="KXU34803">
        <property type="protein sequence ID" value="KXU34803"/>
        <property type="gene ID" value="AXK12_06860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="500" mass="54453" checksum="08BA93F28E5997D1" modified="2016-05-11" version="1">MFSAFTNSLKIPELRSRIFYTLALLFVARVAAHIPLPGIDPHPLQSFFADQTAGGGGTLVGLYNMFTGGALVKGAIAALGIMPYISASIVFQLMTALVPALSRLQQEGDVGRQKLTQYTRYATVLICLVQGTLLILALENPGRLFPGYDVTIYGPIVMVGKLGFLFTSVIYMTAGTMLLMWLGEQITQRGIGNGVSLLITVGILADIPAAATATYQLFFAPIGVARLGLPQAIVMILLFLAVTMGIIMVVQGQRKIPVQYAKRVVGNKVMGGQSSFLPLKVNYSGVMPVIFASAIILFPQQIFSQIGAAFNIKFLTEFSQQLLRGHWSYYAIYTCLILFFSYFWVSIMFKPIQIADDLKKYGGYIPGVRPGAPTAQFLDFIMTRLTLAGAIFLTVIAVMPDFLLFELNVPQRIAIFFGGTGMLITVGVILDTMRQMETFLLQRHYDGFLKKGRVRARAAGARQGMTGDALSSEAVMKLVVPTGIIFAIGIIAWAIQAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX1</accession>
    <name>A0A139SJX1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712505.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06335"/>
    <dbReference type="EnsemblBacteria" id="KXU34855">
        <property type="protein sequence ID" value="KXU34855"/>
        <property type="gene ID" value="AXK12_06335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299240" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="768" mass="84369" checksum="3C3FFFD4CDFA8A42" modified="2016-05-11" version="1">MKSPQLLPVALGLCAFVCCIAPELVAQSSPYSTDQAQQTDDETVVLPAFSVAGDTVDRYRAADAVSSARVRTQLIETPSSITVLPRDLIEDIAPTRVYDATKYIAGVQDGRGNSYQDRITLRGFELSGRTVNSFADTGNHNFDEALIERIEVSKGPNAILSPGGPPGGTVNIVTKAPEFRAKHSLTALVGDFDAQKVTLDTTAPLPGSDRFAYRLIAAYQDTERYLSSTAKLRNKVIAPQLAWRISPTSELVVRYDWFETRTFREQLMIVDPEVVQRGQTPSPAPGFNWRGTNGTPPWSGLSYQKHSLSLEFSTSFNQYLSMRLAGRFQRTGEGSDQAHITTPSASNRYNPYTGILTPNQTWALADPSLAHDANLNPYVATNSPYYDPTAIQLQVSRGLYARGDTYSIQNDWVLSFDTPYAKLQTVAGFAGSDSESVSRGVNGTIAPLNLFDIASHDSTPTWDTALSTDNENEATNWQAYLNQRVTFWEDRIALTGGALHYDTQSKSRNKVRGTSGGLDASKDMFLGSALVRVTPNASLYYSYSTNAAPATFNSQPLWREGKQHEWGAKMEFFERRLGVNFAYFEITQTNFVVANPAYYAGDLNQPTDLLSDYSNHGAELEVMGALTRNLSVMASVTNLKMRDARGRNVRAVADHLAAAMLNYRLQDGALKGLSFTLGANYASERAGDIPVPDFTPLGVVTQTSFFVPSHTRWSAGASYQWSRYTLRLMVDNLTDKKNYFSGAGARFSQPGLASADGRNIRGTITVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX8</accession>
    <name>A0A139SJX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ORF">AXK12_06370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712517.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06370"/>
    <dbReference type="EnsemblBacteria" id="KXU34861">
        <property type="protein sequence ID" value="KXU34861"/>
        <property type="gene ID" value="AXK12_06370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="248" mass="26804" checksum="EE36A30FDC273F25" modified="2016-05-11" version="1">MNDEPPSPSSNAVKYKRIVLKLSGEVLRGGKSGDPIDAPTLQAICNQIKEIHALGVQICVIIGGGNIFRGLQGSKQGVDRTTGDYMGMLATVINGLAIMDCLEKLGVTTRVQSAIPMNQIGEPFILRRAVRHLEKGRVVIFVAGTGNPYFSTDTTAALRASEMRADIIMKATKVDGIYDKDPVLHPDAVKYDELTFLDALKQRLSVMDSTAFSLCLDNNVPILVFDLSDEHAIRKAIAGEKVGTLVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK24</accession>
    <name>A0A139SK24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">AXK12_06305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712497.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06305"/>
    <dbReference type="EnsemblBacteria" id="KXU34850">
        <property type="protein sequence ID" value="KXU34850"/>
        <property type="gene ID" value="AXK12_06305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="32999" checksum="6AC82705844263AB" modified="2016-05-11" version="1">MTYAEIAAALPEQARTASPSLPFPRIASGKVRELFDLGDALLLVASDRLSAFDAILPDGIPGKGIILTQMSLWWFEQTAQLIPNHLLPDQAGEFARRGLTDPDLQLRSMIVRKLRPLPIECVARGYLIGGGWNAYQQAGALCGIPLPAGLRQAEKLPAPLFTPTTKAPKGQSDAPITEPEATALLGSALFEQVKAASLALYEFGATRAEAAGLILADTKFEFGTDEQGALHLIDEVLTPDSSRYWPADRYQIGISPPSYDKQFVRNHLVAIEWDPQSPPPKLPPEVIRRTQQKYLAALEKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK31</accession>
    <name>A0A139SK31_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LptD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06630"/>
    <dbReference type="EnsemblBacteria" id="KXU34903">
        <property type="protein sequence ID" value="KXU34903"/>
        <property type="gene ID" value="AXK12_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LptD" evidence="1">
        <location>
            <begin position="314"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="734" mass="82136" checksum="F07C026900521778" modified="2016-05-11" version="1">MASGSRRLKSPLDKPLISKRLPSVIFRQSLRYPFSLCLLLLSAALLSPAQEESGEPTPAPAAGEAQLSAERSAFDEISGEVIFSGGARFSDGETLLEADEIRYSHTTGEAVAAGHVAFTRGRERLLADSLHYWRADKSFRAQNIRLGRAPYYISGTSAEGTGDEVLVHDALLIAHEPGAFQPRIAARSVRYRHDRDVVARNARFGIGAFTPIVLPKFTYRLNIPLASSLSFDAGYRSTLGAFAETGLYLPLGPDTRIGGVVSGYSKRGVMLGPEAHYEIERSAGLITAGDLQTGFINDYGDRLSDRLGRAVPKHRSFIQWWHSQDVTERLQLSAQLHYWEDSEVLRDFRPSLFYRNQSPDTYVQAVYAADRFFVSGLARLRPNDFAAVQERLPELRFDLPALRLGASGLHAQLQASAAALRERPPGSGAASTRSDRLDTYAALSRPISHADWFSLTPIVGARATHYAKASGGKRRYTRLLGEFGFDAALRASKTWNYQNPVWQIDGLRHLLTPTLGYRYVPQATKGRTWIPPIDTAPFSSYLPVLGLGDTRNIDALEPQHLLRLGLNNTWQTRAADYGSRDLLTLDLAQDLRFDRAAGQRRGSDLHAALAFMPAPWLQFDLYQRTRVDDFSLREVNAGLTLRDGPAWSLRLDSHYLRREINEYVLRYEVAVNEAITLLTRLHYDSRRSRFNEQAYGLRQNLGNIWSVQYTVSIYDGRRRESDFGFNFSVQALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK42</accession>
    <name>A0A139SK42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712442.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06165"/>
    <dbReference type="EnsemblBacteria" id="KXU34949">
        <property type="protein sequence ID" value="KXU34949"/>
        <property type="gene ID" value="AXK12_06165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299278" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="812" mass="89269" checksum="9996B70AD845129B" modified="2016-05-11" version="1">MQKTPFLLLSAALFFGGVSDAASSGDRADFSDSDLVELDRYEVAGLPLADSINPLARATDGLFGDYRSPLETPRAASTITQALLRERGIGGVREFMLYTPGARAAASFGKVTAPTVRGDVAETFLNGQRISYNYFGVFPSFNGIEAIDVVRGPGSAIYGSGFFTGGYVNYVTKQPQFIPETTLTLRVGTWVPGGGAGSASWLNGSWQVDTTAPTADGRSAWRVSYEGKADKTFFRRAGARDDRQDLFLAWTRRPSGSSSGGLTLDANAQVLWQASPQLLGVNRPTQELIDHGIYYSGALPDLGLNPDTGAIAGTINGVTTAKIRRDATLFSPGDFSNAVLTRGQFIATARPSADQKFINRTLGEYINRRRYHEFEYAEYAEQLTIENRSEWHTRFALWGRPHALIAGGTLRYEERESYTNYFNEYFFQYDLSAPPKPEDGKAARYNHPRDYPQSYWEGFRGPGGRLFFPLSYGSSETSASTLWNPALFVQDDVELTDSLALLVGGRLDGFIAKARDPLGEASGIDWRDTRSESAFSWNGSLRYRPRGLADRASFYATYQRAYAVQGHVAGGGIILKEDPDDPTRGVIDPDDFANLSRLAELGAKFALRENALYLGVALYDQRRSEFELGGGRKNLKARGAELELVYQPDARLNATFNVALSDARLDNSTASQAGGTSLYNLYAKGAGPGGRGNGKGFTWEKLPPGDYRIAGHSRLVFNTSGSYQLKNGFGAGLGASWQSEAPGNLTNEYHIPAQLFVDVFVFYRGPRWSVNLDILNALDRRNWAHNGGNFSNHQIVFQELPLRFEGYVKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK54</accession>
    <name>A0A139SK54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712523.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06390"/>
    <dbReference type="EnsemblBacteria" id="KXU34864">
        <property type="protein sequence ID" value="KXU34864"/>
        <property type="gene ID" value="AXK12_06390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="203" mass="22524" checksum="B4E44736D84B1B45" modified="2016-05-11" version="1">MYAALITISYHSANNKVILAAPFYSTLRASKTMPPPSARHEPARQILFAAARADHPEATEPKCKTLFTLVDTCRLLENGLQRDLASSEITENGFLLLALLIREEPKTFTPSEMADQLHLGRPVISTTLGRLEVSGLIRRERSTTDLRSLVVRVTEKGRSVFSAAVAECLKSITHLMAEIPAEELAQLDATCSRLRQHFLNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK61</accession>
    <name>A0A139SK61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_06285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712486.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06285"/>
    <dbReference type="EnsemblBacteria" id="KXU34972">
        <property type="protein sequence ID" value="KXU34972"/>
        <property type="gene ID" value="AXK12_06285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="7">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="8">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="213" mass="24517" checksum="5AC8310A14374262" modified="2016-05-11" version="1">MSLADLRQEYSLAGLRESDLEKDPFRQFDKWFGEAQAAQILEPNAMTLATATHDGRASARVVLLKNFDTRGFVFYTNFESRKGHELSENPHATLLFAWLPIERQVIVSGQVTKVAQEEALAYFHSRPRASQLGAWASQQSSVIPSRDVLDERLRALDAQYAERPIPLPPYWGGYRLAPESVEFWQGRRSRLHDRLRYRRESEGGEWIIERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK63</accession>
    <name>A0A139SK63_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712623.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06700"/>
    <dbReference type="EnsemblBacteria" id="KXU34916">
        <property type="protein sequence ID" value="KXU34916"/>
        <property type="gene ID" value="AXK12_06700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="34812" checksum="878F99392CA9EF82" modified="2016-05-11" version="1">MSSHLSLKALDALLKKIAARRILVVGDVMLDHYIWGDATRISPEAPVPVVDIARDTWTAGGAANVALNIASLGAACTVAGFVSDDEAGSRLRSILDAHHIALLPTPGTGTTILKTRVLVQHQQLCRLDRESPPSAYQFSPKAAEALLAEEIAHADAVILSDYAKGILTDTLVARVTKLARAAGKFIALDPKPKRKLKFRDLDLITPNRRESYELAGLEPAPHAPYPAAEICRRIHRAHGTRHLVITLGEDGLLLSTGGKVTRTIPTAAREVFDVSGAGDTALASLVLALSAGADLETAAHFANAAAGVVVGKLGTAPVTPEELRASSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK79</accession>
    <name>A0A139SK79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureE</name>
        <name evidence="8" type="ORF">AXK12_06510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712566.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06510"/>
    <dbReference type="EnsemblBacteria" id="KXU34884">
        <property type="protein sequence ID" value="KXU34884"/>
        <property type="gene ID" value="AXK12_06510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="176" mass="18838" checksum="E8D8CC9C803B4030" modified="2016-05-11" version="1">MLQLDTRYDGPEPATDTLELDFAARSKTRQRVRLASGEEAALLLERGTLLRGGQKLKASNGRIIAVVAAPEALLEARCQGPLALARAAYHLGNRHVPVEIGEGWLRIQADHVLEHMLLGLGASVHALNAPFEPESGAYAHGGHSHSHDHDPAHSHSHSHAHSHGEGGGAKIHMMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK82</accession>
    <name>A0A139SK82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712584.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06600"/>
    <dbReference type="EnsemblBacteria" id="KXU34897">
        <property type="protein sequence ID" value="KXU34897"/>
        <property type="gene ID" value="AXK12_06600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="737" mass="79695" checksum="FDEA10DCFE9F1578" modified="2016-05-11" version="1">MLVATAHAQLLPPPARRSDTAWPEVETPASPEAEITAATAPRPDSVFPQSTLKRLPAPAAAPEFAADFAADLFNYLAEPESDAITPHAELVISDGKVIELERDWHVTLGTSAGQIRWAGSGGFAAYGRDRFLWVHGDTFPLIWGKTTHFIGASDVLVFGTVDSDATLIWDKKIDLGGGPRTIRLIDNPADRWRTAVRFNQGFTNGDLVFEGIGVADLSAANNDWQGNLTVNQAELRVNVGASLHGLYSITIEQGARFVVDNLGNHASSLGGHYLENRLSQFTTINLNSGAFSYLGQKSGNSFERTGIIELLGGANVIDVTNYRPGQSTVLTLGGLYRDSGATLNLTNSNAAWGGAFGTGGYTPQLKFRDRAGPWAMPELEGGILPWATVNGEHFATLKGKHLVAYTDYYTGDPNTWEAPHNASLTTHQYLSTDRSINSLRFAADSSLQLDAHTKLTLNAGALLSTGGDGLQAIHGGELLTPERELLVHVYKGWFSIHSNIRQTLPSNSSGIGLVKSGDGTLVLESKDLSALRGDHYLHEGTLILARRGDGIGLGGHLFVGNGGRDGAKLELYGDNQLQRSASMTLRGNRIREGIFPDHSNTSLELYSVEQYLDTLTIEGACALNFANGPSVNDLIGFDHIVIADNTSELIVYGWEELTKHLLIHRSAEAEIAQYLGRIKFGYDEDPAHLIDYNADYFEIVPTWYNGAPEPGTTGAVLAAGALGFFAWRRRRVANKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK98</accession>
    <name>A0A139SK98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">AXK12_06635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712598.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06635"/>
    <dbReference type="EnsemblBacteria" id="KXU34904">
        <property type="protein sequence ID" value="KXU34904"/>
        <property type="gene ID" value="AXK12_06635"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="307" mass="31292" checksum="3149E73A3449E10C" modified="2016-05-11" version="1">MAILVTPETKVLIQGITGAFGAKHAQLSLDYGSAVVAGVTPGKGGQVFEHAGHRVPIFNSVAEAAAATGATVSAIFVPPPFAADAILECVDAELDLAVAITEGIPVKDMVRVKRAMQGRKTRLIGPNCPGLVTPGTGADSHGGCRIGIAPGYIHRKGHVGIVSRSGTLTYEAVYQFTTRGIGQSTCVGIGGDPVNGTSHLDVIKLFNDDPDTHAIIMIGEIGGSAEVEAARWIKAHCKKPVAGFIAGTTAPAGRRMGHAGAIVGGAEDTAAAKIASFKECGIEVAETPSDMAEALIRAAKAKGVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA0</accession>
    <name>A0A139SKA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712457.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06200"/>
    <dbReference type="EnsemblBacteria" id="KXU34956">
        <property type="protein sequence ID" value="KXU34956"/>
        <property type="gene ID" value="AXK12_06200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="14974" checksum="A84AF51302CE01E6" modified="2016-05-11" version="1">MSDTPAFFATPGYGERQLKTFHYSQAVRVGARIETSGQGGWTDDFQFPHAELRDEIAQAFENVGRTLACAGASWEHVIQVNSYHVGFTPEVNTIMTELFRKHMPNHAPIWTLLGVAALGDPKMRVEIRVTAIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE3</accession>
    <name>A0A139SKE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_06245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06245"/>
    <dbReference type="EnsemblBacteria" id="KXU34964">
        <property type="protein sequence ID" value="KXU34964"/>
        <property type="gene ID" value="AXK12_06245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="7"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="528" mass="57020" checksum="29E86A99C5F21345" modified="2016-05-11" version="1">MEIIHTDCLVIGSGLAGSAYALHAARAGLRVELLCLDTPLAANSDWAQGGIIYENSAQPELLAADIITASDGTANPAAVEHLVREGPAALKALLLDELAVPFDRDTGGGLEFTREGGHSTRRIIHAKDTTGHAILKTVAQRVDATPNITRRSGGVAIDLLTLSHNSREPADRYAPLTCYGAYVLDSTRGEVRAIIAKKTVLATGGLGQIFRHSTNQPGSVGHGIAMAYRVGARLIDLEYVQFHPTVFFKKNAPRFLITEAIRGEGAVLVNARGNRFMEAAHPLGELAPRDIVSRAIHEELAATGEPCVYLDLSALAPDFIKNRFPAILARCAEHGVDITRDPIPVVPAAHFSCGGVHSDLQGRTNVRHLNAIGETGCTGLHGANRLASTSLLECLTSAQFTAQADAAEIATLGDSGFRLPKPPAWKAAKRDADPTLIRQDLQLLRSTMWNYAGVVRSPKRLTRARRILLELREEIQSFYRDCRVTRELVELRNAIETSLLVVRAASLNPISKGCHYLRSRPSTAQQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY1</accession>
    <name>A0A139SKY1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine synthase</fullName>
            <ecNumber evidence="5">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_05690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05690"/>
    <dbReference type="EnsemblBacteria" id="KXU35196">
        <property type="protein sequence ID" value="KXU35196"/>
        <property type="gene ID" value="AXK12_05690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4 5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pterin-binding" evidence="10">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="13">
        <location>
            <begin position="335"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="12">
        <location>
            <begin position="438"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="11">
        <location>
            <begin position="589"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="7">
        <location>
            <begin position="448"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="7">
        <location>
            <begin position="892"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="927" mass="101120" checksum="A66F08AD3CBAC997" modified="2016-05-11" version="1">MPSPELTPSPSDALTQSAPATPQPQNRSASFIVIGERTNITGSPKFARALKAADWDTCLSIAKQQVENGANLIDINVDEALIDGEATIVTLLNLIAAEPDICRVPIMLDSSKWSVLEAGLRCLQGKGIVNSISLKDGEAEFLRRARLIQRYGAAAVVMAFDEQGQAATRDEKVRICTREYRLLTEQLGFPPEDIIFDPNVLTVATGIEEHNHYAVDFFEATALIKQTLPHARVSGGISNISFSFRGNNPVREAMHTAFLYHGIKAGLDMGIVNAGLLGVYDQIEPTLRDLVDDVLLDRRADATERLIEHADQLKATSEAKASGTTAETSSSAAAAANAWRDAPVAARISHALVKGIDAYIEADTEEARQSLPRPLDVIEGPLMDGMRVVGDLFGAGKMFLPQVVKSARVMKRAVAYLTPFMDEEKRQLLARGGEARAQGKVIMATVKGDVHDIGKNIVGVVLACNNYEVIDLGVMVPCEKILATARETGADIIGLSGLITPSLDEMVHVAKEMTRADLRIPLLIGGATTSAAHTAVKIAPEYAHGVIHVLDASRVVGVVSALLSDTQKPGFLAENAAKQDKQRADFAARLGKRALLPLATARSRAPRYDWATIDIPRPEFLGTRVYSSAEKRSKDVVALTLQEIADYIDWRPFFSTWELHGRFPDLLTDPVVGEEATKLYRDAQTMLADIIAENRYTARAVLAFWPANRIGDSVEIYTDESRAQVRHTFHFLRQQLEKPADQHNHCLADYIAPRDSGRVDYLGGFAVTAGPEVEESAARFKTAGDDYNAIMAQALGDRLAEALAELMHKKAREACGYGRAETLTMADIIRERYRGIRPAPGYPACPDHTQKPPLFALLDATTATGIQLTESCAMTPGSSVSGFYFNHPDSKYFAVGKLARDQVEDYATRSGEPLESTEKWLAPYLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY4</accession>
    <name>A0A139SKY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AXK12_05940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712240.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05940"/>
    <dbReference type="EnsemblBacteria" id="KXU35238">
        <property type="protein sequence ID" value="KXU35238"/>
        <property type="gene ID" value="AXK12_05940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="64"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="477"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="590"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="901"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="944" mass="102928" checksum="4A26B484111587A2" modified="2016-05-11" version="1">MASKTTKKAPAKKAAPKATQKNSGSPAAAKVSAAKAKTGKATKSPKYVYTWGAGKADGDGTMKALLGGKGANLAEMTRIGLPVPAGFTITTEVCTYYYANKRSYPKELEAQMQAGVANMEKVMGHKFGDAKGFPLLVAVRSGARDSMPGMMDTILNLGLNDDTVRSLEKATGNARFAWDCYRRFVQMYGDVVLGVQKREGEDHEPFESVIEHYKHEVYGRDIIDSELSAEDQQELVKRFKALVKERTGKVFPHDPWAQLRGAAGAVFGSWMNDRAIVYRRKYNIPTEWGTAVNVQAMVFGNTGEASGSGVAFTRNPANGENEFYGEFLINAQGEDVVAGVRTPEPVSKLKAAMPKAYAELLKVRKTLEKHFKDVQDVEFTVQDGKLYMLQTRNGKRTAAAALKFAADMVKERLIDWKTAVLRNPADQLEQLLAPIFDLAEIKKAKAIATGLPAGPGAASGKIYFNADRAAAAAEKGEKVLLVRVETSPEDLRGMIAAEGILTARGGVSSHAALVARQMGKVCVCGAADIQIDYERRVATVKGQNFAEGDYLSIDGTAGTVYAGQIPTAPSEIIDGLLNGNKAAQKTEKFKNYVQLMDWCKKATKLKVRTNADTPEQTAQALAFGAEGIGLTRTEHMFFEGDRIDAMREMILAETQADRETALAKLLPYQRKDFFGIFKALKGFPATIRLLDPPLHEFLPHSKEQQLDFSKKIGVAVEKVMTRVHELHEFNPMLGFRGCRLGVKYPEITKMQVRAILEAAAEATKKGFKAKPEIMIPLVGFKKELDQQVALVHEVAAAIEKEKKVKLSYQVGTMIEVPRGALTADEIAETAEFFSFGTNDLTQTTLGMSRDDSGSFLGAYQETEIMPKNPFASVDQSGVGQLMEIAIEKARRTRADIKLGICGEHGGDPDSVKFCHRIGLAYVSCSPYRVPVARLAAAQAAIANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL52</accession>
    <name>A0A139SL52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712054.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05455"/>
    <dbReference type="EnsemblBacteria" id="KXU35296">
        <property type="protein sequence ID" value="KXU35296"/>
        <property type="gene ID" value="AXK12_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="315" mass="35395" checksum="834657FDDE016334" modified="2016-05-11" version="1">MLDIKKGSPIGVLRRLEWRVRHAVENVLSGEYRSAFRGRGMEFDQVVRYEFGDDVRDIDWNVTARLGEPYRKKFVEERELTLLVLFEDTPSLNFGSGAQTKREALLELAGLLMLLGAVNRDRVGFIHTAPDGHGGEAHTFRPPVRGRGAILHHAAQLLSIPPPAMTSPAETKAETARQRLTTIIKGSATPRHSIVVWLGDFAPRAQPEGWPALCRRYQMMGFRVDDPWERQFPTDAAFGSLVDGPLAAYDPLAGRLVTLENSAAARAAHATWVRQREDAWAALFPIAHNRLVLSTEDDRLDALVRFFQKRMQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL69</accession>
    <name>A0A139SL69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35309">
        <property type="protein sequence ID" value="KXU35309"/>
        <property type="gene ID" value="AXK12_05535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="268" mass="28248" checksum="460CE3BB05925DC8" modified="2016-05-11" version="1">MSGGSKRVGPRPEDSPRRLWGAALAVAALALLLLLGLLSLNLGGELEPSEVARTAPSRNRAAQPVGLQPIRSQQSPHGESDLVAAEALFFDPSPLFLPTRWNAGAVDMPETILQEAEELFEDYAPQLSFAREGIGSGLLGNTDSAELRAAELVFSDEDGVGLSVIGRGAEEPARLPERSGRLEVRETATARRVVVRDLVPPTTPAGAANWQPLELAAVIDAAGLVGPVTLVHSSGVEAVDEFFRDYVVSGLHLGERVGPGVYQILAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL73</accession>
    <name>A0A139SL73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="8" type="ORF">AXK12_05495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712079.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05495"/>
    <dbReference type="EnsemblBacteria" id="KXU35303">
        <property type="protein sequence ID" value="KXU35303"/>
        <property type="gene ID" value="AXK12_05495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="189" mass="19716" checksum="6CCC26ED5ACFE245" modified="2016-05-11" version="1">MRAEKQYLVAEVETHLKKSDYVILTNFAGITVSDVAELRTSLAAEKAEFHVVKNSSLRVAAKGLGLPDIDESLKGPTAIVVGGENSAGVAKVLKKFFESKQKLEIKLGVMEQKLVSAAELSAIADLPSFDALRAQFLSLLQANASAFVRVLDAKVKKDNEGAPAAEAASEAPAAAEAPAAEAAAAPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE9</accession>
    <name>A0A139SLE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711970.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05265"/>
    <dbReference type="EnsemblBacteria" id="KXU35381">
        <property type="protein sequence ID" value="KXU35381"/>
        <property type="gene ID" value="AXK12_05265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="645" mass="72044" checksum="1DBDE12D1B05B9AC" modified="2016-05-11" version="1">MSSKTEKTLDFAALPDKRWPGRLIVGGKTLDDFVAIAEEPSQEAGWTVRVFQSTTAPELQIRAQWRTIGAVTEWIPTLINNSAKPSERVTGVRSLAASWPTRGPVDFYGNKGSEARLDDFLDRTELDIDTITLMPNGGRSSDGIFPFFALTDRHDSLAIGIGWSGRWDATLRHASGTLEIEIGLPQVGFVLRPGESVRLPSILLAQAPEATADQARRLVRAHLMKHVVPRGPDGNIFNLISHGTMHQYHVTRVVSEQIEIEAMERAAALGFEAHWVDACWYGNTTDWDNEVGNWNIRRSDFPRGLRPISDRAHELGMKFIIWMDPERARPNTEWPRTHPELFLSYPDPNSPDPYTRRGILLNLGDPRAVDLAFEKISSLITEFNADIYRQDFNMAPLEAWYAADAPDRVGITEIRHVEGLYALWDRIRAAHPGIMIDNCASGGRRIDLETLRRAVMLTRSDAVDVGEEGASEMDIVNQIQCWGLGHWLVVHSGLNATFDAYAIRGALCAGFMAYRVLPENDQDPEYADAIAAVSEMKRLRSFVAEERIGLIAPDLEKEAWTAYQHHRHSDSSGIIVALRGPGADTDSVTLHPEHIDANATYQVIRWDDYRQSPATQLSGAALKEMVVTIAQTRSSVLVEYQRVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH4</accession>
    <name>A0A139SLH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712003.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05355"/>
    <dbReference type="EnsemblBacteria" id="KXU35397">
        <property type="protein sequence ID" value="KXU35397"/>
        <property type="gene ID" value="AXK12_05355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="320" mass="35184" checksum="B1544458BCF42BDE" modified="2016-05-11" version="1">MKDILRFHPVYQQRVWGGRAIETAFGRQLPAGEVIGESWEIVDRPEAQSVVASGPQAGRTLGELVKTQAAELLGPQWPSDRAFPILVKWLDCRERLSLQVHPPAEQARELGGEPKTENWYIADTAEGGAELTVGLKKGVTREGFERAIIEQRVEDCVHTFRVAEGDSILVHSGQVHAIGPGNLILEIQQNSDSTYRVCDWGRVGLDGRPRELHVHESLKCIQWDDYEPAPVRAAPTSEVIADCDEFRIRRLVLGPGERLSFAAGEQPRILSVVSGRLRVDEGGSLGGELVRGDHALVPYSAGFEAEAGEFGIVLVTENFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLL9</accession>
    <name>A0A139SLL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711987.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35390">
        <property type="protein sequence ID" value="KXU35390"/>
        <property type="gene ID" value="AXK12_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="420" mass="44998" checksum="B6657CB724B67250" modified="2016-05-11" version="1">MKTLLRDFRIRRLIIANILSSMGVGITLITIPWLIVQREGGAELYGWNNIAATIVLLIFAPYYGSWLDKHSRKTALVAGEAFGALTAAAMTAWILATGVSENWQLLLLFFCGVLYYSLHFPAKFAFIQQVFDRRHYQSLLGLMEVQGQIATMLAGGLASVLIDRLPFGLILLFNAATYAASFFILRTLPYRATHLAADDSANHDHPDPTTAAPTPPESPVMSFITGLRWMMGERLAFSVFLICTLAPFIAVMVGGYMFPVYVQTVLEASASVYGRGEVALAIGAILAGLALPRLITGHSQAGLAIGLMGLFLAGLGLLSLVPGTGAFYVALLMLGLGNAGARVVRGSVMLHSVPNALMGRVNVVMATAERLIRTLLMLGAIALISRGLSPTLGFAGLILFMLLSVGLAWATRRAVSPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS0</accession>
    <name>A0A139SLS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711907.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05080"/>
    <dbReference type="EnsemblBacteria" id="KXU35496">
        <property type="protein sequence ID" value="KXU35496"/>
        <property type="gene ID" value="AXK12_05080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="78" mass="8657" checksum="BE4A43B6F8C3640F" modified="2016-05-11" version="1">MANKADKWENNVAGSFYVDQQCIDCDLCRETAPDFFNRFDEGGYSYVYNQPTSEDDLALCMEALEGCPVEAIGNDGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM52</accession>
    <name>A0A139SM52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">AXK12_05015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711876.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05015"/>
    <dbReference type="EnsemblBacteria" id="KXU35611">
        <property type="protein sequence ID" value="KXU35611"/>
        <property type="gene ID" value="AXK12_05015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="1-deoxy-D-xylulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="249" mass="27063" checksum="5A66FE51BFB19F43" modified="2016-05-11" version="1">MILLGLNIDHCATLRQARYRDVTHRGNPIVEPDVLALALVAEAAGADGITAHLREDRRHMQDADIVELRARIATRINLEMACTPEMVALALRVRPDSVCLVPESREEVTTEGGLDVAGQRDRVREVVAAMSAAGVATSLFIDPEPVQIDLAAELGAPWVELHTGAYANAYYANDGRRATEFARLREGALRAHALGLRVNAGHGINYTNIAEVRTLPHLHELNIGHSIISRALATGLAEAVREMRALMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM56</accession>
    <name>A0A139SM56_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YiiD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711838.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04920"/>
    <dbReference type="EnsemblBacteria" id="KXU35658">
        <property type="protein sequence ID" value="KXU35658"/>
        <property type="gene ID" value="AXK12_04920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012660">
        <property type="entry name" value="YiiD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09500">
        <property type="entry name" value="YiiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02447">
        <property type="entry name" value="yiiD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="YiiD_C" evidence="2">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="153" mass="16609" checksum="1584CC553AB893DB" modified="2016-05-11" version="1">MKSLKVPAFQLFLHEMIPLAKMMGVGVEVSDDRALVLKAPKEQNVNSLGTAFGGSLVSLATLAGYGVVWELMKGKNTAEWRIVVKESRAAYRRPVLGDLRAICERPAQAAINEFKDALTRYGKAKLKLHARVVEEGQTAVDVRAAFVVSKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SML9</accession>
    <name>A0A139SML9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00080"/>
    <dbReference type="EnsemblBacteria" id="KXU35846">
        <property type="protein sequence ID" value="KXU35846"/>
        <property type="gene ID" value="AXK12_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="138" mass="14606" checksum="F4A5144FE2BFB243" modified="2016-05-11" version="1">MSTETPPSDTTANASAPLGGSSTAAILSYIPVIGFIIALILHNGQKTELGTYHLRQSLGLHLTAFVLFFGATIFFMIVGIIPLVNIVFGAIAMVYFPLLSLGSVVFFILGLISAAQGQQKPLPLVGGKYQSWFANSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA3</accession>
    <name>A0A139SNA3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_04240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711550.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04240"/>
    <dbReference type="EnsemblBacteria" id="KXU36039">
        <property type="protein sequence ID" value="KXU36039"/>
        <property type="gene ID" value="AXK12_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022625">
        <property type="entry name" value="TypeI_RM_Rsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12008">
        <property type="entry name" value="EcoR124_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="295"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118766" checksum="9E197C56318B568C" modified="2016-05-11" version="1">MVDFSKPIAESNNFIVLDRYVKEWKVAESYQSEGDLEREFIQDLVNQGYEYLPELKTPEALLINVREQLQALNHVRFSDGEWARFMETWLDKPGDGIVEKTRKIHDDYIHDFVFDDGRIQNITLLDKKHITRNKVQVIKQFEQTGSHVNRYDVTVLVNGLPLVQVELKKRGVAIREAFNQVHRYSKESFNSEHSLFRYLQLFVISNGTDTRYFANTTQLSKHSFDFTIHWAKADNSPITDLKDFTATFFQQHTLVNVLLTYSVFDVGNALLVMRPYQIAATERILWKIKSAYQAKHWSRTEGSGYVWHTTGSGKTLTSFKAARLATALEFIDKVFFVVDRKDLDYQTMKEYQRFSPGSVNGSDSTAGLKRNLGKNDNKIIVTTIQKLNNLMRSEHDLPVYRQQVVFIFDECHRSQFGEAQKNLKKRFKRFYQFGFTGTPIFPDNALGAKTTASVFGCRLHSYVITDAIRDEKVLKFKVDYNDVRPQFKAIESEQDEKKLSAAENRQALLHPERIREITRYILNNFQQKTHRLQAGSNGYNAMFAVSSVDAAKLYYESFKVLQKDGDKPLKVATIFSFAANEEQHAKGDIADESFEISALNKSAKEFLSAAIADYNTLFKTNFGVDGKGFQNYYRDIAKRVKQQEVDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLIQAYSRTNRIHDASKSFGNIVTFRDLEQATIDAITLFGDKNTHNVVLEKSYRDYMEGFTDATTDKTRRGFMDVVSELEQRFPDPAQIIRESDKKSFVKLFGEYLRLENVLQNYDEFASLKALQNIDMNDVQAVEAFKARYYLSDADLTALQAIKLPSKRTIQNCSSTYHDIREWQRQKRFAAEKESSSIDWNDVVFEVDLLKSQEINLDYILGLVFENNKKINNKDALIEDIRRMIRASLGNRAKETLVVDFIHQTDLDQLGDKPEMIAAFFSFAQAEQQREARAIIDAEGLQPEAATRYLQISLKRECASENGTELNALLPKMSPLNPAYLTKKQSVFQKIAAFVEKFKGVGGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA5</accession>
    <name>A0A139SNA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711584.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36055">
        <property type="protein sequence ID" value="KXU36055"/>
        <property type="gene ID" value="AXK12_04340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="552" mass="60280" checksum="884F410DA14EF5D6" modified="2016-05-11" version="1">MFAKPRSRAALLLLVAAAVAFVGQGVSLFLGAKTLAKAKSELAAKEGWLTSLANAEPAPTQAVADALAREFAELRNAVGQAESLWRDNSITRALCDSPPPPNSRAAYFEIARYRQALAGLAGEQGIEIAQDEFFGFRAYANVGPSEADILRVYTQRLGLERVLGALFRSKPQRLLAVIREERNASPEAPWQDESGSADASYRFQIRFLGTTAVLRTWLNELASDRLPVLVRSVTVEPGAERQVIPDRGRPTAALSLSSFGETGDSDGFELLVRPSGSEFLVTLDYVELGAEEEVEALTEGFSRFSENSPERVMTWPAPESQVRGPQWIFDVFTPPEIFYHPAEQQFRVKALRPSADPALTAHALPDSQNGELTVPRLLGVRREDYPLQLSGYIGGAGSDGLRGDCVGPFLGLFENRESGELLLLRGGDRVESLGIEVLDFRVEMQSVAHDEGTPFRAPRAVARIRDVQGERRSLYEGERAEGHALIAEVEWYGERLELREGDVVAGEEGALLTVSEIQCAPQPRAVMKSHATAPESEWLVFTLESAPAGSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH9</accession>
    <name>A0A139SNH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711458.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03990"/>
    <dbReference type="EnsemblBacteria" id="KXU36183">
        <property type="protein sequence ID" value="KXU36183"/>
        <property type="gene ID" value="AXK12_03990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="349" mass="37608" checksum="11614D35D1B51E36" modified="2016-05-11" version="1">MSDPVSISALKTYTIQNEAGASADILNYGGIITALRVPDRAGVLGDVVLGFAKPEEYLAEPYKKNSCPYLGSILGRIAGRVTGGKLRLPNGRTYELAITDGPNHLHGGVCALDKRLWEVKHTAPDSITLFYHSPDGEEGYPGALDITLSYTLRHDNALVVETTAINRSDFATPLSLSQHSYFNLAGEGSGDVLDHEVQILADHIIPPLDDTLTLSGALTSVAGRADDLRKARRLGDVVSGLFLEHGAHYFLRAKALTPDWPELVARAYEPKSGRQLEVLTNDCGLQFYTGSGLNLSCVGKSGLPYGPHAGLCFECEGYPDGAHRPELGDILVHPGTPQRRSTIYAFSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ5</accession>
    <name>A0A139SNJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine diphosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711615.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04430"/>
    <dbReference type="EnsemblBacteria" id="KXU36070">
        <property type="protein sequence ID" value="KXU36070"/>
        <property type="gene ID" value="AXK12_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="234" mass="24926" checksum="6E7869B67E7E08E3" modified="2016-05-11" version="1">MHAADFFALPESLSCFTPHFAAEAAPWEWLRQIGPALAVAQQQTQRLSPSLPPAEIPSGVHIEGWVHLDPSVKLPAYATLIGPLWIGAGTEIRPGAYLRGNVIVGAGCVLGNACEFKNALLLDRVQVPHFSYVGDSVLGNRTHLGAGVVCSNLRLDQAEIAVDVGEQVVMTGLRKFGAILGDEAEVGCNAVLMPGTVLGRRSVVMPLTPFGGVLEADTSARCRPTISRRVVCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ7</accession>
    <name>A0A139SNJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711598.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04375"/>
    <dbReference type="EnsemblBacteria" id="KXU36062">
        <property type="protein sequence ID" value="KXU36062"/>
        <property type="gene ID" value="AXK12_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="557" mass="58959" checksum="53929DD101803123" modified="2016-05-11" version="1">MIGQLLGGIGLFLLGILLLTDGLRTAAGQTLKRILSQFTERKTSAFLSGLTITAMVQSSSATTLATIGFVSAGLITFSQSIGVIIGSSVGTTTTGWIVSLLGLKLSLFTIAMPLVGIGALMRLMLKGRIASVGFAIAGFGLIFIGIDTLQHGMNSLAAHVQPEAFPEPSLTGRLILVGIGIALTVIMQASSAAVATAITAYHSGTLDIAQALSIVIGASIGTTLTAGIAAIGASTSARRTALVHILFNSFSAAIGFALMPLYVWLLTHLDPESNSAPGAWSIAVFHTLFHIVGAGIALPGAEAFSRIITRLIPERKPAPTSHLDDSLAQVPEVAFEALRRALVECTLILTAWIKHRSDSRHPEAALSPEAVHDSLEHGYAFLSRLPATVPIKPGATNPRLSLIHAMDHLDQIVGVLKTVHSYPESDPSGRLDQAREKLFALFTELERLVSSHSLKTDENAEAQRSDSTEALAQIEQLSQTLAALRRTGRHALLRETAEAALSPAKADELLEAVRWMDTAAYHLWRAAYHLAHAADPAEQDPHKHAPAHGPECATAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN2</accession>
    <name>A0A139SNN2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 20" type="primary">secA</name>
        <name evidence="20" type="ORF">AXK12_04560</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711662.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04560"/>
    <dbReference type="EnsemblBacteria" id="KXU36094">
        <property type="protein sequence ID" value="KXU36094"/>
        <property type="gene ID" value="AXK12_04560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="3"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="544"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="954"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KXU36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113973" checksum="C017AE975E4481A8" modified="2016-05-11" version="1">MFSFLFKRFAGRHYKKFLERSRPIVAQINEFEASYQSLSDEQLRAKTDEFRARIAAAEDKHAALAELLPEAFAVVKNAARRLQGRTITVCDHELVWDMVHFDVQLIGGLAIHEGRIAEMATGEGKTLVSTLPLYLNALTGRNTQLVTVNDYLARRDSEWMGHLYNFLGVTVGCVQQQMPSELRREMYSRDITYGTASEFGFDYLRDNGMATRREDQVQRDHWFCIVDEIDSILVDEARTPLIISGPAPVEREQPFTRLRPAIDRLVSAQERLCNTLIAEARATLEKGSAASEDERRAAITKMLQVKIGHPKNKQLLRLQETAEWRKALDKFETEMSSDFNKAEYYRLKEALYYAIDERQQQADLTELGRQQLRPDNPDAFVLPDLATEYSELDRESAGTPEEREAGKLAAQQRFAEVSEEIHSISQLLRAYSLYEKDIEYVVQDGKVMIVDENTGRVMPGRRWSDGLHQAIEAKEGVTIERETRTYATITIQNYFRMYEKLAGMTGTAETEASEFHDIYKLAVQVVPTNKPCIRIDANDSIFKTRRDKYNAVVKEIEDAHRRGQPVLVGTVSVESSEVLSRMLKRAGIIHTVLNAKFHEQEAEIVARAGLSGAVTIATNMAGRGTDIKLGPGVREAGGLYVIGTERHESRRIDRQLRGRCSRQGDPGMTKFFLSLEDNLMRLFLQGNLASRLMEGSMKEGEELAHPWLNRSIESAQKKVEQQNYSIRKRLLQYDDVLNQQREVIYGIRNAAIHSERPKDIIFEQVQEEILTRFENAGYGEKAAPGAAEIDQLVGWINSHFPIGLKPEELSATGDLDTLAADVLARVEKAYAVKESVEIPEALGALERYVIINAIDRHWQEHLTEMEELRRSIGLRSYGQKDPLVEYKGEAFKYFEELMNNVRLQICTGLFRSASNIEAFENMLALLSRSARAQGPADALPAGAAGARGSVNTANRLGASSSSGAAPASGAASAPGGSREIQLPKVTIRRDMPKVGRNDPCPCGSGKKYKNCHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP0</accession>
    <name>A0A139SNP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03950"/>
    <dbReference type="EnsemblBacteria" id="KXU36176">
        <property type="protein sequence ID" value="KXU36176"/>
        <property type="gene ID" value="AXK12_03950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="159"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="378" mass="39844" checksum="F8BC36649E749F3E" modified="2016-05-11" version="1">MPRQAHFSPPAKPTAPSRPFGFAIVGSGMIAHYHARAIAATAGARLVGIASRNAETAQKLADEARSFLPTGHAAPTATTDLATLLAHPEVDVVCVATPSGAHLEPALAAIAAAKHLVIEKPLEITTARIDQLLAAALAADVVVAPIFQARFGKNAQHIKAALDAGRFGRIVLASAYVKWFREPAYYRGWKGTRALDGGGATMNQAIHGIDLLQWFVGMPTQVVGHSTRRVHTGIESEDTAVAALRYPSGALGTIEASTAAYPGWARRIEICGEHGSVTLEDDALTRWDFRDKRPEDSAILAAAADSAMGSGATNPSAISAEGHTRQIRDLVAHLSARREGRAELPRLGIEAHEARNAVSLIRALYDSASQGSQPVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNQ8</accession>
    <name>A0A139SNQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711672.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36101">
        <property type="protein sequence ID" value="KXU36101"/>
        <property type="gene ID" value="AXK12_04140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="346" mass="36859" checksum="A13777005BBD9BC5" modified="2016-05-11" version="1">MRLLIVGTGSMAAYHVEAFKKIPNVEIVGGVDVRAEQLAAFNEKHGIANGFASVEEAITWGQFDAASNVTPDRFHYPTTLSLLAAGKHVLCEKPLATNAAHALEMAEAAAKAGVVNAVHFSYRRGAALQKAAELVSEGAIGEVRFFEASYLQNWLHLEWQTRPECLWRLSTAHGSRGALGDTGVHIVDFTTYVAGQAVTSVSGLLTTYDNKAPGGKVGDYVLDANDSATMQLKLANGAVGTITTTRVASGHGNDLRLRIYGTKGGLEVSDKDGASQMRACIGADMETSEWRVVDCPAITPIHERFIAAIRGEKTPLPPNFARGAEVQRVLDAAEESAAKGSQIITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS2</accession>
    <name>A0A139SNS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711328.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03620"/>
    <dbReference type="EnsemblBacteria" id="KXU36237">
        <property type="protein sequence ID" value="KXU36237"/>
        <property type="gene ID" value="AXK12_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="310" mass="34139" checksum="37548F8B4D2B1D8B" modified="2016-05-11" version="1">MQDYIQANTNGHLHDAREASISPLDRGFLYGDAVYEVWRTYDSVVFAWAEHWARLEQSAAALGFILRCSPEQMFGEIRRTAAAYRVATSDTSDLYIRLQITRGAGTIGLDPGLADGASFVILVRANKGIPDDKLRAGYTLSLATTLRRNSSETLNPAWKTGNYLNNILCLGEARRRGADEVVMTNLAGEVAESSVCNLGFVRRSAGESGAVEIVTPPLRSGILAGITRELMLAKIAPEAGFAMREAVIRPEDFSDFEECFLMATTRDIAPVGQIDGRHFRVGERTVTMRLKAAFSDYVARYVAVHPEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNX8</accession>
    <name>A0A139SNX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_04025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04025"/>
    <dbReference type="EnsemblBacteria" id="KXU36190">
        <property type="protein sequence ID" value="KXU36190"/>
        <property type="gene ID" value="AXK12_04025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="364"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="479" mass="52813" checksum="FF6A85E5132EFDBF" modified="2016-05-11" version="1">MSPGRHYLSRRTKIIFTIGPATESEQMLEALICAGADVIRLNMAHANHEWTRTIMRRIRTVSARVGRDVAILMDIKGPEIRTGDLETPIELRVGEIFDFTVKPGSDRRDAEEVRSVDVNYRDLVNDIRVGDTVLVDNGLITLEVLAKDDAHIRCRVLAGGELKSRRHINLPGVTVNLPSLTEKDRADAAVGIEEGVDFIALSFVRSAADIALLREFLAEKKSKARIIAKVEDQSGITNLDEIVLSSDALMIARGDLGIECPLEELPIIQRRAVRSCLANARPVIVATHMLESMITQPIPTRAEITDVANAIYELADCVMLSGETTVGRYPLECVQTLDKVARRIERETNGLPPDIALFTSERMKILHSATVLANQIPGSKILTFTRRGTMPHGLAALRPASAPILTFTPDAALLRQLRLLRAVEPYLMPLPSEPEAMIEDAIRLLKQAGRITTGDKLIVATDILSGDRFVESVQLRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNY7</accession>
    <name>A0A139SNY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711413.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03865"/>
    <dbReference type="EnsemblBacteria" id="KXU36200">
        <property type="protein sequence ID" value="KXU36200"/>
        <property type="gene ID" value="AXK12_03865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="157" mass="16927" checksum="39D196AB4658EF85" modified="2016-05-11" version="1">MDIKQIKQIIDLIRRSELTEFAIEEKDFKLKICREGTAAAAAPVVLPAQSLLAPSAPLPTAPASAASISAPAPAEEEDVTYIKSPMVGTFYHASSPDSAPFVEEGTKVTETSLVCIIEAMKIMNEIQAETKGTIIEVLVENGQPVEYGQHLFKVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP11</accession>
    <name>A0A139SP11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711296.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36220">
        <property type="protein sequence ID" value="KXU36220"/>
        <property type="gene ID" value="AXK12_03520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="121" mass="12656" checksum="ADAFDA5CC499712D" modified="2016-05-11" version="1">MNPSRSPLPPHAPQSRRSVDETWATLIRAARHASVDDTETSAPLGFSVRVAALGLAARRAAPSLLESFSLRALGLAGLAAVLAFAVHFSVPKSVAAADEELFFTVEDPSALLLGESGGTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP13</accession>
    <name>A0A139SP13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711248.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03365"/>
    <dbReference type="EnsemblBacteria" id="KXU36339">
        <property type="protein sequence ID" value="KXU36339"/>
        <property type="gene ID" value="AXK12_03365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="30984" checksum="11D06DACCF77697D" modified="2016-05-11" version="1">MNLIDTHTHLDSFVQRGELDAVLERATAAGVGALVTVGTGSDDWPLYREIATTHSGGGCAVYYTVGLHPCSVGADWESEVAQIEAYFSDAVGVGLGRADSADAQNKKGARPPVALGECGLDRFHLPKDDPAQAEQVFAWQRAAFSAQLAIARRLGCPVEVHSRGAFAESVALIDESGVDWGKVVFHCFSEGPAEMSELVARGGRGSFTGILTYKNAQSVREAAQVQGLKRLMLETDAPYLTPMPHRGKRPNEPAFLRHTADYAAEFFGVSVETLAEITTRNAREFFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP26</accession>
    <name>A0A139SP26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711273.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03470"/>
    <dbReference type="EnsemblBacteria" id="KXU36355">
        <property type="protein sequence ID" value="KXU36355"/>
        <property type="gene ID" value="AXK12_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="90"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="343" mass="38301" checksum="38DFEA7328AF5A1A" modified="2016-05-11" version="1">MPKYKLEYIWLDGYSPLANLRSKTQIKEFAAFPTLADLPQWNFDGSSTKQAEGSSADCLLKPVGVYPDSTRKNGVLVMCEVLLPDGSPHPSNTRATIPDDEGAWFGFEQEFFFYKDGAPLGFPPGGYPAPQGLYYTGVGFESIGALARDLVEQHMDICLDAGLNYEGTNAEVAKGQWEFQIFGKGSKKAADEIWVARYLLTRLTERYGIDIEWECKPIRGRFGTPLDWNGSGMHANFSTKHMREVGGKDYFEKLMGAFSKYMDEHIAVYGPDNHMRLTGLHETQSIDKFTYGVADRGSSIRIPHVFVNNGYRGYLEDRRPNSAADPYLVAGRILKTVQSVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP28</accession>
    <name>A0A139SP28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA processing protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711377.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03795"/>
    <dbReference type="EnsemblBacteria" id="KXU36264">
        <property type="protein sequence ID" value="KXU36264"/>
        <property type="gene ID" value="AXK12_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="375" mass="40223" checksum="A42E16D80DD190F0" modified="2016-05-11" version="1">MTDELTLTQARLILNALPEIGPITLNRLLEDLGDDPREVLCASPQKLESTRGVGPKISATVHGWRSHFDLPREEARMADAHTDFIIPEDGIYPPLLREISDPPIGLYRKGDYDFSLPSIAIVGSRRTTLYGQAIAKKFAAELARLGFCIVSGLAQGIDTAAHEGALSVGGKTVAVLGNGIDIVYPPQNLDLYRQIEATGAIISEFPFGRRADRQTFPMRNRVISGICDAVLVVESAVSGGSMITARFAGEQNRLLCAIPGRIDQATSGGCHQLIRDGAVLATSVEDILSELDYGHGQQPRFPPLDGNGEDEKTATPALTEQEAQILACFAGGAILTPDTLAAQTGLSASALAPALMMLELKHCLTRRLDGSWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP60</accession>
    <name>A0A139SP60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711391.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03715"/>
    <dbReference type="EnsemblBacteria" id="KXU36270">
        <property type="protein sequence ID" value="KXU36270"/>
        <property type="gene ID" value="AXK12_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="24009" checksum="21F1C222D88D2B6F" modified="2016-05-11" version="1">MLKALIVWGGWSGHEPKPCADVVEKILTEEGFAVQVEEGTQAFAAHDLNSFDLIVPIVTMGKLESEEGARLFEAVKNGVGLAGFHGGAGDSFRGNLGYQYMIGGQFISHPGGHIDYAVNITRPDDPIVSGISDFVYHSEQYYMHVDPSNEVLATTTFTGEHDYWIEGTVMPVVWKRKFGKGRVFYSALGHDAKEFEVPQMREILRRGMLWATRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPE2</accession>
    <name>A0A139SPE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711226.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03250"/>
    <dbReference type="EnsemblBacteria" id="KXU36475">
        <property type="protein sequence ID" value="KXU36475"/>
        <property type="gene ID" value="AXK12_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="137" mass="15110" checksum="B93F24C8BABB7C27" modified="2016-05-11" version="1">MKISVKVDYACRVLAEMARLQGSGELAQIDHLAKTEAVPANFLAQILSELRNAGLIISKRGIQGGYALARPADQISLYDVMVAIDGDLLELSGNHKGRSGPRVKEIWLTLRETLHTQARAHTLDTFVIKETADMYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPI3</accession>
    <name>A0A139SPI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03205"/>
    <dbReference type="EnsemblBacteria" id="KXU36467">
        <property type="protein sequence ID" value="KXU36467"/>
        <property type="gene ID" value="AXK12_03205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="319" mass="36732" checksum="782516A17A65749A" modified="2016-05-11" version="1">MGRLAVLMFFAISGFVIPSSLRGGRWEGVKRFALRRFWRLYPAYWLVLLMTCFWGFSYPIERLPWDATMLPSLRRFAGLGWAHGFLHFWTLEVELIFYITLAFLFMIFGRLRLRLLLFGYISLVLCTTWGAFPVGAAPQYSPIPSIMVMFWGAVCREILRFDFSKYTEFVPMKGVNWSRSLAIGLVTAPLVIIGLYYFIYGGSNEWGRVETRFGLSLLFAVIGFLFWVVLTPIRINWLSAVGRWTYSTYLFHFLIIIGVRNFIASNNPGGLSFILHGWPLPVYVVGLLVLCFAVGAVAYRWIEQPSDRVGKWLTAKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPR4</accession>
    <name>A0A139SPR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711221.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03220"/>
    <dbReference type="EnsemblBacteria" id="KXU36470">
        <property type="protein sequence ID" value="KXU36470"/>
        <property type="gene ID" value="AXK12_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="255" mass="26459" checksum="1D0864FDE6C6EDC6" modified="2016-05-11" version="1">MSLVGAGPGAVDLLTIRGQRLLAQADVVVYDDLANAELLDFCPDEARRIYVGKRGGRRSLPQEQITQILVSEALKGLHVVRLKGGDPLVFGRGGEEIAVLAEAGIAYEIVPGVTAAVAAGASIGVPLTHREHASSVVFVTGHECAGKGPEQEGVNWPALAASGATLCIYMGVRRLAEIVGKLIDGGAQGTTPVAIVANATLRSQELYTTTLAEAAQFAEQLKGKPSLIIVGQVVRLAGSGTSHWESVISQVPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPR8</accession>
    <name>A0A139SPR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711232.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03280"/>
    <dbReference type="EnsemblBacteria" id="KXU36480">
        <property type="protein sequence ID" value="KXU36480"/>
        <property type="gene ID" value="AXK12_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="295" mass="34138" checksum="AB99C577DB7252B2" modified="2016-05-11" version="1">MQIENFKIFADLVETKSFSKSAKLNGITQSAVSQQARAMERHFKSLLIDRSQKQFQLTREGQQVYESAKDILHTYEKLLSELQELKKVISGTIRISTIYSIGLHELPPYIKKFLQDYPSVNVRVEYRRSNLVYEDILHNSVDFGLVAFPVKTRQIEILPFREDKLMLITHPTHPLSRRVDVELKDLVGQRFIGFDPDIPTRKAVDMIFRDHRIELDPIMEFDNIETVKRAVEIDHGIAIVPYATVMQEVKQGSLAAVPFREENFTRPLAILHRKGRVLTPAMRKFIETLGHNLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPT9</accession>
    <name>A0A139SPT9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711222.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03225"/>
    <dbReference type="EnsemblBacteria" id="KXU36471">
        <property type="protein sequence ID" value="KXU36471"/>
        <property type="gene ID" value="AXK12_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="354"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="479"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="599" mass="65001" checksum="DD8E91F8579EA715" modified="2016-05-11" version="1">MSTATATPASTEAPKLSKNELLKDAAPTLAGNLAATMADPAADRFSEDDTQFLKFHGAYQQDDRDLRKTGKKFMMMIRARIPGGVMTANQYRVFDDLSTEYGNNTMRLTTRQSIQFHGVLLHGLGPLIKRINDSLLSTLAACGDVNRNITASPTPATTRARELVYQDSVRLAEALAPQTKAYHSIWIDGVQLDLDDPENKDFVDPLYGKTYLPRKFKTSLVIPPVNDMDVLTNDLGFIAITEGDTLLGYNVVAGGGMGRSHGQVQTFPRLASLIGFTKPEDVIEVAKAVLTIHRDYGDRTNRKHARLKYVVQEKGAEWVTAEVNRRTGGLLAAARPYEFTTTADLYGWNRAVDGSLFLTLYVQTGRIKDSEGHALKTALRQVAEKFPHIEFRLSANQNVILANIPEADRAAIDALLSSHGVKTADQAPILHAASMACPSLPTCGLALAESERMLPGLIDRIATLGGSLGLGGEEIIIRSTGCPNGCARPYMAELAFVGKAPGRYQVWIGGNASGTRLNRVFKEMIKEADVETEIGPLFARWKAERVANERFGDFAARVIWPELEIAQAAAADEARKKAAAAAASATTPAPAPKPKLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ08</accession>
    <name>A0A139SQ08_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ORF">AXK12_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711131.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02755"/>
    <dbReference type="EnsemblBacteria" id="KXU36695">
        <property type="protein sequence ID" value="KXU36695"/>
        <property type="gene ID" value="AXK12_02755"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="24512" checksum="FA1E180F87B29175" modified="2016-05-11" version="1">MSIAEAQSIIENRAAELRVQLAALPSDWKHAATRDGRSGVTLEIGCGHGHFIAAYAAAHCEEPCLAIDIIAERLARAQKKLDRAALTNVVLLRSEARLLLDNLPDWLRFRRVFVLFPDPWPKRRHHKNRLLQPDFLKSLARHCTADARLYFRTDHAPYFAEVAELLRTHPDWEMAGDGEPWGFEQETVFQKRAGGYYQSCIARVGAGEWAARKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ28</accession>
    <name>A0A139SQ28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase F0F1 subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711135.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02775"/>
    <dbReference type="EnsemblBacteria" id="KXU36699">
        <property type="protein sequence ID" value="KXU36699"/>
        <property type="gene ID" value="AXK12_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="132" mass="14163" checksum="A228A6BB04EEC941" modified="2016-05-11" version="1">MAAAPSKASQQLARQLFGLSLANGLVTAERVEGVLAYLEKHPPAQPLAVLEAYRRLVARELAKGELIVEHAGPIAEGILRSLEGAFTQKYKRQVTARSVHNASLIAGLRLHIGDDLYEASIAQQLSQLTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ44</accession>
    <name>A0A139SQ44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711160.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02925"/>
    <dbReference type="EnsemblBacteria" id="KXU36725">
        <property type="protein sequence ID" value="KXU36725"/>
        <property type="gene ID" value="AXK12_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="353"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="525" mass="57310" checksum="BA6CC122901447EE" modified="2016-05-11" version="1">MFKKLISAVRGVFTPAKPASKKNPSSATTRRKSASTENPRRNPRGEKTRKTGGAAGERGSRGAAGESREGRGGEGSRGKPRSDSKGRSRSERANRAAPKKRVADDFEHPRREPIKPVVPVDVPKMDSAFSALGLCDALAYAVQEKGYTEPTPIQAQSIPVILEGRDLIGSAQTGTGKTAAFALPIIQKLGGHGPLRCLVLEPTRELALQVEEAFQHYAKFTDLAVTIVYGGVGYGKQLEDLQRGVDILAATPGRLLDHLEQGNCSLADVDILVLDEVDRMLDMGFLPDVKRIVQQTPKSRQTLFFTATVPPEIASLAGWALRDPVRVEIGRQRSPAETVAHAFYPVVATQKFELLELLLEQTEFKSVIVFTRTRMGADRIASRLRESGHTVGVLHSDRSQRERVEALQGFKSGKFEVLVATDIAARGLDIAGVSHVVNYDVPENAEDYVHRIGRTGRAQTSGDAFTLVTEEDVRDARSIERYMGVAVERKKIDGFPYIYSALFDEGAQGGASPKPASRLHRGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ53</accession>
    <name>A0A139SQ53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">AXK12_02760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711132.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02760"/>
    <dbReference type="EnsemblBacteria" id="KXU36696">
        <property type="protein sequence ID" value="KXU36696"/>
        <property type="gene ID" value="AXK12_02760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299315" description="ATP synthase subunit a" evidence="12">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="31239" checksum="6019987275FD5A59" modified="2016-05-11" version="1">MSLAPKLALPALFLSSGMSAFAAVDPAASQFLGGWVTNSMLTGWAVSLVLALVIVKLIGKPSLLPTKRQAVFESLLEALRGLFEPIVGKKAFPAAFPLLVTFFIFILVQNYAGLLPGVGTVGYGHTDAEGHFHITRALVRPFTADFNSTIALALISFGAWLIIIFKYAGPKMILWDLFGNKADKKDTPGWLYPILSLVFLVVGLIEVFSICIRPFTLSVRLFGNVFGGENLLHGTGFVFVFYFMELMVGLIQAIVFTLLSAVYIGLITNHDDGHDAEHGDAAHPAEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ82</accession>
    <name>A0A139SQ82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711184.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03080"/>
    <dbReference type="EnsemblBacteria" id="KXU36749">
        <property type="protein sequence ID" value="KXU36749"/>
        <property type="gene ID" value="AXK12_03080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="318" mass="33750" checksum="9C6BD34D452370AB" modified="2016-05-11" version="1">MTFSEQLAHYTAQVEDALDALLPPATARPTRLHEAMRYAVLGGGKRLRPTLCLAAAELFEPTKLRRGGDDTAPSETACAPAPPAAAFGAAVSIECLHCYSLVHDDLPCMDDDDLRRGRPTTHRAFDEATALLAGDALLTHAFALLAEHYADSPALAHALTRELAHAAGSRRLIGGQMEDLLAEKKQGTENAVTAETLDFIHLNKTAAMIEAALVMGGLVGGADGPQCETLRTVGRHLGLGFQIVDDILDATADTATLGKTAGKDARAEKTTYVSLYGIDAAQARAEEETQRALAALATLPGDTRFLADLTRSLTDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA7</accession>
    <name>A0A139SQA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711157.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36722">
        <property type="protein sequence ID" value="KXU36722"/>
        <property type="gene ID" value="AXK12_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="147" mass="17029" checksum="10D8B3EE7C57D849" modified="2016-05-11" version="1">MKKLRFLLLFAALGLLVGCNTFEKRLTQRPGVFESLDADTQAKIRAGIIDIGYTADMVFLAIGNPDSRSDHITATERKKVWIYNAYHRDYHGVQHVGYHRYLRYNPVAKTYYPIYVPIMADVYSDRIELRLRVVFEDGKVSQIEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQF2</accession>
    <name>A0A139SQF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36720">
        <property type="protein sequence ID" value="KXU36720"/>
        <property type="gene ID" value="AXK12_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021557">
        <property type="entry name" value="DUF3016"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11454">
        <property type="entry name" value="DUF3016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="169" mass="18735" checksum="87025C37D0FECE40" modified="2016-05-11" version="1">MALVGSGCESLAVKNAAAAEAAAAKVEVEFVDPETFTDVKDALVATEKGRAHTIEEVRQYLVETAARYVPEGQHLKITVADIDMAGDYEFWGRTGHSDIRIIKAIYPPSIDLAFVLSDASGTVLKAGERRLHDLAFQMRIDLRDTDRLRYEKALIDDWLRDEFGPPIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQK1</accession>
    <name>A0A139SQK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711117.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36879">
        <property type="protein sequence ID" value="KXU36879"/>
        <property type="gene ID" value="AXK12_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="117" mass="14097" checksum="BAC6041CFC188E63" modified="2016-05-11" version="1">MYQVTFSEQSLRELKQLDTLAQLELIEPISSLKPSDLARPREPLGRFKRGETLYYRLRAGDYRFYFEAQGETLHTHYILHKNSLEDFLLRNKLPVSEEQLFEQHSKFWKYLESLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQU2</accession>
    <name>A0A139SQU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">AXK12_02575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711096.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02575"/>
    <dbReference type="EnsemblBacteria" id="KXU36918">
        <property type="protein sequence ID" value="KXU36918"/>
        <property type="gene ID" value="AXK12_02575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="369"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="436" mass="47225" checksum="A43EC090D6FF9A85" modified="2016-05-11" version="1">MNLIEDLKWRGLLADCTDLDALAERLASERPITLYCGFDPTGDSLHVGHLMGQLTLRRFQLAGHHPLALAGGATGMVGDPSGKSAERNLLSPDALAHNVACIKAQLARLLDFDSPTNPARLVDNAAWTAPISFLDFLRDVGKHFSLNAMIAKDSVRSRMEGDHGISYTEFSYQLLQAHDFYHLRKTHNCELQIGGSDQWGNITAGTDLIRKKLGTPAWGWTFPLITKSDGTKFGKTAGGAVWLDPQKTSPYKFYQFFINTEDAKVCEYLRKFTFLSRAQIESLEAAHAANPGAREAHKALAREVTTLVHGADAVDAAIKASAILFGAEIGDISEATFRDVVGEIPTIPFAKTALEAQSDSGNGEATVGAPLIELLVHSGLCPSKGQARKDISGGGIYLNNVRETAPTRSVTTADLLFGKHLLLRKGKRSYAVITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRA6</accession>
    <name>A0A139SRA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="7" type="ORF">AXK12_02355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711058.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02355"/>
    <dbReference type="EnsemblBacteria" id="KXU37010">
        <property type="protein sequence ID" value="KXU37010"/>
        <property type="gene ID" value="AXK12_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="40"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="495" mass="50723" checksum="386642B0908D52BA" modified="2016-05-11" version="1">MSAQSGIPLEPTAPAVGQDALLEASAAETPPATDFPPPPLIKLVGVGGAGVNIVSRLSAEPFASAGGGAGEAGGGESGDPCANAVGGLALAVMDCDARKLGESPVGEKWLLGEGQRRGLSAGGDIELGRQAAEASREMIASAGGGADLLFLVAGLGGGTGSAAASLVATEASKAGGLVIGFAVLPFSFEGGRRSKQAEAALVSLRRVCDAVIVLPNDLLLQEASEGASALAAFEQADEWIARAVRALWRLLCKTGLMNVDFAALQRAFEYRGSKTVFGLGFGTLAAEPLTPDALADQVLASLRACPLMHAPEAARRADRLLVSVAGGASVLTLSLVNRLVHSIGEHFGRSAELIVGATLDEDLGERIELCLIGASDIGGNSRRAMTSATHARTTRAARHSASPQNESGEAASQKTRESVDSRERTAPPRGGVERLAALKGRGSLNARSDTPHQGEFGFSAEAERGYFSNTEATLFDGQDLDPPTYLRKGIKIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRQ3</accession>
    <name>A0A139SRQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">AXK12_02195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02195"/>
    <dbReference type="EnsemblBacteria" id="KXU37160">
        <property type="protein sequence ID" value="KXU37160"/>
        <property type="gene ID" value="AXK12_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="184" mass="20192" checksum="9513384ED6A4C652" modified="2016-05-11" version="1">MSATALLPTSLLATTETLVLGGGCFWCTEAAFKLLPGVTEVTSGYAGGVTDNPSYEEVCAGHTGHAEVIRIQYNPQEISLERLLDFFWEAHDPTTLNRQGADAGTQYRSIILYQSPEQKAAAAAAITRAQPRFSAAIVTELVPLARFWPAEDYHQDYFRKNPQAGYCRLVIAPKVQKLEKAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRX5</accession>
    <name>A0A139SRX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711010.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02105"/>
    <dbReference type="EnsemblBacteria" id="KXU37230">
        <property type="protein sequence ID" value="KXU37230"/>
        <property type="gene ID" value="AXK12_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="SSF110069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="139" mass="15013" checksum="9950C9CF231D4C22" modified="2016-05-11" version="1">MSLPSCELPGLSARLDKLCYHNGGVSLPADKPHAFVYFITLRNASDRTVKLLARKWVLEHEDGSRAVLEGDGIVGETPRLAPGEAFSYNSYHVTGSSAVAHGAFHGVDAYGNKIHVILPPFAMKVPEGQIQENRTGDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS17</accession>
    <name>A0A139SS17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase sigma-54 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_02000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710981.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02000"/>
    <dbReference type="EnsemblBacteria" id="KXU37395">
        <property type="protein sequence ID" value="KXU37395"/>
        <property type="gene ID" value="AXK12_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="11">
        <location>
            <begin position="130"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="10">
        <location>
            <begin position="342"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="501" mass="55651" checksum="50FDD500787B9001" modified="2016-05-11" version="1">MAAPEFYHSQEQRQTQSLVLAPQMRQALKLLQVAAIDLHAEIQEELQKNPTLEELPSDSDSISLDAPPTPPSGHAEAGSPSTENESTLPSPAELDFAKSGEPLLPSGSDTQQPYSNADAERRQHFFDSLVAAPSLYEQLAAQAALADLSPAQQRALDYLIGALDERGFLSQSLEDAAAQSGLALSDISTAAEALRNFDPPGIGARSLPECLLLQLRHKTADQDLPAEHSEESAASFALAERIIAEQFELLTRRRIGELTRALGASPEAVQRAIELIGRLDTAPGRRFAADSNQIIEPDIEVWRDSDRQWQLMLNRRYIPRLRISATYRDLIAKGTLAESERDYLRERMRAGRTLIDSIEQRQHTLERLARELLTLQHAFFEHGPTHLKPLTMGELAERLGVHETTVSRAAANKFIKTPHGLFPLRYFFTTGYQADSGTPVANTSVKEWIADLIAAEDRDAPLSDQAIVEKLRERGLHLARRTVTKYREALNLPPSNLRKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS22</accession>
    <name>A0A139SS22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YfiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710973.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01950"/>
    <dbReference type="EnsemblBacteria" id="KXU37386">
        <property type="protein sequence ID" value="KXU37386"/>
        <property type="gene ID" value="AXK12_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299407" description="YfiO domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="168"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="358" mass="40100" checksum="41B4660C2F09B7F5" modified="2016-05-11" version="1">MAFLKNRAVALRGLLSTAALIALSLLAPAARAVDVTWDPASGWSSESGTPVGLSSLDDRKSALALMNRARAAEERGNNGAAVKRYRRVVKRYPTSIYTPEALYRSADLYLKRHQYNKAFDAYSQLIARYPNTDRFNEIVGRQYQIASSMLEGARNRWWGLIPGFKDRTKGVQQFEVVVWEAPYSDYAPLSMMAIGRGHQHLGNELEAIDAYDRMINNYPDSPLGPDAYLRLAEAHASLVDGPEYDQASTQEAATYFEDFLILFPGDPGVARAEEGLDEMRTVLAESKVKMGDFYFKKRDNYTAARVFYNEAITTYPDSEIAERARAQLVKVEAAAAKHQPADDAAPARAKRKKRFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS51</accession>
    <name>A0A139SS51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">plsX</name>
        <name evidence="5" type="ORF">AXK12_01960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710975.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01960"/>
    <dbReference type="EnsemblBacteria" id="KXU37388">
        <property type="protein sequence ID" value="KXU37388"/>
        <property type="gene ID" value="AXK12_01960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="376" mass="39232" checksum="57B771DB293703A9" modified="2016-05-11" version="1">MPQPRDTQRIAVDAMGGDLGPAEVVEAVKLALAQQPALNPITLVGDEAQLVPLLDRAGLRVGDSERLALLHAPEVITMDDKPVLALRRKKNSSMLRAIELVKDGSASVVVSCGNTGALMAGGTLRLRTMQGVARPALAAVVPRAGGHFVLIDAGANPDARPEHLLHNAILGSHYCRVRLHTKATTAPRVGLMSIGTEEGKGNALTAEAHALLRSAHDAGILNYSGQIEGFQVFAEAGGGGVDVVVCDGFVGNIMLKSWESLVKFFSSIIKTELRANPLRMAGALMAKGAFSALKSRIDPDSHSGAPLLGLRGNILKAHGSSKRTAICAAICAAGEIITAEMNQHIEADVRRAAPLLSSSAQARAEIASSPPPSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS66</accession>
    <name>A0A139SS66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01860"/>
    <dbReference type="EnsemblBacteria" id="KXU37372">
        <property type="protein sequence ID" value="KXU37372"/>
        <property type="gene ID" value="AXK12_01860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299410" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="343" mass="37362" checksum="8595B7547CC52EE3" modified="2016-05-11" version="1">MSVCGFRFMTFPLRLLSFVSSCALLVGCGPTDQSAPSKNADEAAAGLTPVIMQTDWFPQAEHGGFYQALARGFYREAGLDVDVRPGGPSSHVRLRVARGDADFGLLRSDDTAMAISQGLPLVMVAASLQHDGEALLVHADSPVQDFSDLDGQTVMAPLSMVWVSYIQKKYDVVFKLVPTTYGLASFFADPALVRSCYLTSEPFLAQERGVPVRALPLIDAEYDAYAGVVVRRELVRSSPELVRAFVAATLRGWEDYLNGDPSPADTLILERNPQMSQGQLDYSRAALIEHSMVAGFPEKGERIGAIDMGRLQHEIDRLREFDALAKALSAEDIATLEFLPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS69</accession>
    <name>A0A139SS69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710940.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01755"/>
    <dbReference type="EnsemblBacteria" id="KXU37426">
        <property type="protein sequence ID" value="KXU37426"/>
        <property type="gene ID" value="AXK12_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="600" mass="66503" checksum="8D32E54187CE92C5" modified="2016-05-11" version="1">MLKRSFIIAALVLTLALPFALRPPSEKSRRGEKADDTLVIISPHNEAIRYEFGRAFRHWYRERTGRSITVDWRAIGGTSEITRFIESEYLTAFQNHWTKTLGRPWSAEVQAAFANPQLDRNDESGDDAAFDGEVKNGSVTPRVARAAFLASEVSCGIDLFFGGGAYDFIRQAAAGRLVPSRIFQTHPQWFADDVVPQHYAGEPYWDAQGRWAGVVLGGYGILYNKDALARLGVEEAPQQWADLCDPRFFREVALCDPTKSGSIAKAFENLIQQQMQARLAELLRANASAGASLVNPQFDGNETLGVNTAFDGEAKNGASTLRAVREGWEAGLRIIQLMGANARYFTDSAQKPPIDVSQGDSAVGICIDFYGRYQAEATTRRDNTDRRAAPVSDRATPLAAGRLVYVSPRGGSVSSADPIGLLRGAPHREAAELFIEFTLSMEGQTLWNFKVGTEGGPTRFALRRIPIRRDFYAREEWRRLRSDPDTRPYAQEDALVYNAAWTGPLFREMAFVIRVMCLDTHDELVAAWREIIAAGMPADALAVLQDMSLLSYDRVGGEIRASLRSKNRADELRLARELGAQLRTQYAKAAAIARAATPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSB5</accession>
    <name>A0A139SSB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01850"/>
    <dbReference type="EnsemblBacteria" id="KXU37370">
        <property type="protein sequence ID" value="KXU37370"/>
        <property type="gene ID" value="AXK12_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1103" mass="118250" checksum="A597FA3CDDEE064F" modified="2016-05-11" version="1">METNINGTVYFSANTGWDGFIINHSQGGLRFGGLIQGSRYLRVSGSGATHFAGNLDIGGGIETVPGSGTHLILSGEALYYLNLRVGAETLVFVKRNKALGSVNSYLTIDYGGTLGIRSHVGESLNYSEQATLNVSGPGAVRALGRPAVGAIYHDGGGSPTDLNQFAGTIIMTGDTTFGARGDAGGLLLSGEVYSSTYPSNDSFSKVGLGLITLSNPNNDWTGSTIIWDGVLRTAIDTTFGAPPGSAIPTFSTIYLKGGILELGDTNFNGVLGSKIQWGDDFGNDASGGFSAFGGNRSVEIQNWAGGLAWLTWGAGGFVGNNRALLLSSRYANAQIDFKNPINLGNGSREIRVERGHTDAHARLSGAITASGFGRLVKTGPGMLWLTEPIDYQVQVNEGVLRGTLGGGFGNSNLRLSGGVFGLDSDFTGSLGTGPGQVIWGSDFGLPASGGFAAYGGDRIVRLNNTPFWADIAGHPGFVQPDQELRFGHYTADGTVIWDKELSIERIRVERGRNPNVADVRFTQAILPEWFSGSEIRFVGDGRADITSHIARTTHVSGVELRLHDGGMISGNNVFLNILNGGVVTLDNLTGSNHPDRLNDSSKVSVFLSGGTLRLWGQPNGTSQELADPLLLQSIFQSSPGTLAASNTIELKHNSTGISDFTELRFAFLYKEDFFTLNYRTYDRFNAILEDFSKARLSFTFWSPSDAINHVATGTKITPWGVVNGLDFMTPVAANGVTELRPVTNYYTNTNSNNWNPSINLFLDEYSTSTLVGNRAINSLKIGDGASLTSNANYTLTINSGGLLAYSGEANTGGRLTIRTANNRPLYAHIYGSSLGLTGSSRFDVPNLVKTGPGALNLGSAATHNVPNLYIHEGTVNLSQGTLHVNNIYIGDGAGRDILVLPANSTDALRRATGRTFPNVFLRGTPHGLDPSNVYGGEQSDQAILRLSGNTKQHLAVLNVMERGTIDFAGGEVGLANILWIDQLNFLNAAGNSYDPSARLFIRNWYQYEDYLLISRGWINTYQPTQLAEFLNQIVFDGYQDFRLVALDYDSQYYAITPFNHVSGVPEPQTYGAILAAVGIGMVVWAKRRPVRQRARRSVKQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSD1</accession>
    <name>A0A139SSD1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="16" type="ORF">AXK12_01970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01970"/>
    <dbReference type="EnsemblBacteria" id="KXU37390">
        <property type="protein sequence ID" value="KXU37390"/>
        <property type="gene ID" value="AXK12_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299358" description="Undecaprenyl-diphosphatase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="347" mass="36422" checksum="68C1FFA1E1D8B24E" modified="2016-05-11" version="1">MRRNLPILSFPTLALACLFTLTTRAHARAETPEHSEVAAPLAPLTPGQAIVLGLVEGVTEFLPVSSTGHLILTNQFLALDSEEALRDAAGSPLWHKPPNPDAPEGEPLTIKVAADTYTVVIQVGAILAVLSLYWPSCLKLLRGLLGRDREGLLLLRNLVLAFVPVALVGLLASDFIEAYLFSVAAVIGGLVGGAVLMLAVEAWRRKKTPSAAHPTDADKQPAQLTPTESLKVGLIQCLALWPGASRSMLTIVGGYWAGLSPARAAEFSFLVGLPVLAGAAILKGWRSGPEMIAVFGAPSVLLGMAVAAISAALAVKFLIKILTRSGLAPFALYRLVLAAAVAVVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSH6</accession>
    <name>A0A139SSH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710934.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01715"/>
    <dbReference type="EnsemblBacteria" id="KXU37421">
        <property type="protein sequence ID" value="KXU37421"/>
        <property type="gene ID" value="AXK12_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="92" mass="10400" checksum="82DE21CC5A301FA0" modified="2016-05-11" version="1">MDNMQYEQVYFSGRVQGVGFRQAVLQAAREFEVAGFVQNLSDGRVLLEVEGKAAEIDGLVSAVEERMHGYVRQTERGEPEQREAVYAGFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSI0</accession>
    <name>A0A139SSI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710924.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01655"/>
    <dbReference type="EnsemblBacteria" id="KXU37517">
        <property type="protein sequence ID" value="KXU37517"/>
        <property type="gene ID" value="AXK12_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="128" mass="14746" checksum="415740BFDE9CFB54" modified="2016-05-11" version="1">MNRTNAHEVIISGIHLDLTPSLKTYVNEKTERLFRHEERIMRIRVELECDSKASVDSRFIAKGHMSINGPELTASVASDECHKAISLLTDKLDRMLRRRARLFKEKRNHPRAIDLPDVELPKLQFAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST45</accession>
    <name>A0A139ST45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710902.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01555"/>
    <dbReference type="EnsemblBacteria" id="KXU37651">
        <property type="protein sequence ID" value="KXU37651"/>
        <property type="gene ID" value="AXK12_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="480" mass="52854" checksum="3E473436E46BD3BF" modified="2016-05-11" version="1">MDELQEHPFLQGALSHLLTVAGFLLALFLIARLLSEKRQPGNTFAWLLGIVLVPYIGVPLYFLFGGRKLRRLMARKTPVEPTLPVTDFTPGHHANRPIARAVSHAGGSPPLPCNSLQLVTTGEDAYRQLVEQIRHAQHHIHITTFILGRDDTGRRLIDLLAERARDGIKVRLLLDSVGSMFITRHFVRPLVEAGGEVQWFMPVLPFSSRRSSANLRSHRKIAVIDHSTALIGGHNLATDYMGPDAHDGRWTDFGTVVRGPAAILLNDVFIADWCFASHQAIEKIRAEIPPETASQVCGPAELQVVASGPDVHGDPLYEGLVAMIQSANQSICIITPYFIPDEVLQRSLIVKARSGVAVTLLVPAKSNHPITDFARRHYLRELREAGVTVKLHGPRMLHSKATIVDGAIALFGSANFDLRSLFVNFEIGVLVHSQAEVAQIAAWADSLLANAAHSPTAPKRHQRFVQHLLEDLSRLLAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STM6</accession>
    <name>A0A139STM6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37832">
        <property type="protein sequence ID" value="KXU37832"/>
        <property type="gene ID" value="AXK12_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="190" mass="19244" checksum="A4755A5132F0BF58" modified="2016-05-11" version="1">MAATARLAALAKGGGGGLGTIALESALRAQQAEQPMQLSSSLVLAVGLAVSLAATVSAGAHGVRHQVEQTRATVITLTYDDGTPLVGARFEAGPAGAAQATLSGQTDARGRAVVIADTPGPWQLRAFATDGHGARVEFDVSASAGADRAQAGLNGSGAATLPKWLGLVLIAAVFAALQQWLRTRTRRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STM9</accession>
    <name>A0A139STM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ORF">AXK12_00880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710776.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00880"/>
    <dbReference type="EnsemblBacteria" id="KXU37947">
        <property type="protein sequence ID" value="KXU37947"/>
        <property type="gene ID" value="AXK12_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="498" mass="52729" checksum="E1B75C1DACF05859" modified="2016-05-11" version="1">MSTATSAPSALAPLHSQTIAELSARLVRGELSAVELTKAVIERTRAVEPQVKAFNSFDEADALAQAAASDVRRAAGEALGPLDGIPIGLKDVIAVRDQPLTASSRMLANFVSPYDATVTERLKNAGAVLWGRLNLDEFAMGSSTENSATQTTRNPWDLACVPGGSSGGSAAAVAAGQAIATLGSDTGGSIRQPAAFCGVVGLKPSYGLVSRYGLIAFASSLDQIGPFTRTVEDAALLLQAIAGHDARDSTSFNTQIPDYRAALAQAGKPSAWKLGVPKEYFGEGIDAEVSAAVERAIEFYRAQGCEIVEVSLPHTRYCLDVYYVLATAEASSNLARYDGIRYGHRAQGASDIVDLYFKSRAEGFGEEVKRRIILGTYVLSSGYYDAYYLRAQKVRRLVTQDFLNAYAKVDALITPTVPAPAFKVGAKADPLALYLCDIYTIGANLAGLPAISLPCGFTAGGLPIGLQLIGQPFGEAALLRIAQAYETAHDWHRRVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN3</accession>
    <name>A0A139STN3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00890"/>
    <dbReference type="EnsemblBacteria" id="KXU37949">
        <property type="protein sequence ID" value="KXU37949"/>
        <property type="gene ID" value="AXK12_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021272">
        <property type="entry name" value="DUF2851"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11013">
        <property type="entry name" value="DUF2851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="401" mass="44944" checksum="A74D726D820CE0BC" modified="2016-05-11" version="1">MGTYGPFTFSEKLFQKIWDQGAFDQARLETVDGQRIRIERRGKWNHLGGPDFRHARLRIGEEGRAVEGDIELHLYAGDWAAHGHAADPAYDRVRLHVVLFPPAEGKRTFARDGSEIPTACLLPLLHHDLEEYAAEEAVETLAGRRTDTLAEAIRALAPEALRERLVGLAAQRWAQKLRYAGLRVRRLGFDEACHQTALEVLGFRFNRVPMLNLALRYPLATWAGVDEAELDARFAEQEQAWARAAVRPANQPRRRLAQYARWASACPQWPTRLGELAVGWPVPSMEDDTRALRRGLSRAALRDEISLKICDRAVRGTRLDTLICDGLLPLAALRTGRDFSGLWWHWWAGDLPGFLRNARSDLRSVVTPQCQGAIQALIAWALELEAVSSLRAAADTAASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ4</accession>
    <name>A0A139STQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapF</name>
        <name evidence="4" type="ORF">AXK12_00950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710787.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00950"/>
    <dbReference type="EnsemblBacteria" id="KXU37956">
        <property type="protein sequence ID" value="KXU37956"/>
        <property type="gene ID" value="AXK12_00950"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="35982" checksum="70EE90E947410373" modified="2016-05-11" version="1">MKFYKYHALGNDYLVLNPADFPAQATSACKLLDGPAGNDRTPSKWGSAPPSEAEVRLLCHRHYGLGSDGILWGPVETLDNVADAVGDRAKQDNAAQPRPNGRPRMLRIYNPDGSEAEKSGNGLRIFARYLAEHGLVQGDTFTLQTVGGLARVEIIDRAAWRLCIGMGRATFASAEIPVAGPSRDVLGESLDLGRDRHFSFCAASVGNPHCVVPLPEISEELARRYGPEIETHPLFPNRINVQFMQVIDRANIRIEIWERGAGYTLASGTSSSAAAAVAHRLGLVDSQVTVHMPGGTLEINIAPDWEITLTGTVTKVSEGQLSPDLFSFLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STX5</accession>
    <name>A0A139STX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710745.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00695"/>
    <dbReference type="EnsemblBacteria" id="KXU38058">
        <property type="protein sequence ID" value="KXU38058"/>
        <property type="gene ID" value="AXK12_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299443" evidence="1">
        <location>
            <begin position="23"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="148"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU38058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="674" mass="76340" checksum="A93FEA07391B28D8" modified="2016-05-11" version="1">MHRRFFPHTLSALAAAALLLTACGPKTDSTKPRADSQAPAALSDNTGAAQARAFYAEHPEFFHFKTPADIPADLAWEDGAELPEVGSPAAKKGGTFNTWMQDFPRTLRTVGPDSNGSFRGWILDNVSLGYAHRHPNLTDLREDGFHYLPALADRWALDRETKTVYIHLNPAARWNDGVPITTDDALFSFFFYRSPHIRAPWYNNFYGTKYAGITRFDAHTFALHFHALRPDIYSLALGLSPTPAHFYADFGEDFTERYQWRVAPSTGPYTIARDADIAKGRSITLTRVKDWWARDLKHFRYRFNPDRIRISVIRDSAKAFEAFRKGDLDTYGLGLAEDWYDKLPDTAPEVAKGYIQKIKFYNDTPRPTYGLWMNQATPLLANRDIRLGVQHATNWQLVIDKFARGDWSRMQTTADGYGDFTHPTLRARDYDIDAALAHFAAAGFTRRGPDGILVNAAGQRLSLQLTTGYEHFKDMLTILQEEAIKAGLDLRIEILDGTAAWKKAQEKKHEILFAAFNVGAEMFPRYWETYHSVNAYDVPFIENADGSLAPNPARKPKPQSNNLQSIADPQIDAMIDAYDRSDDLAEMRALAYRLEEALHADASFSPGFVTPFLRHGAWRWLRLPEDGNVKIANSLESSLLFWIEPDLKKETLDARKTGKAFEPAILIFDQYKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STY6</accession>
    <name>A0A139STY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">AXK12_00855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710771.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00855"/>
    <dbReference type="EnsemblBacteria" id="KXU37942">
        <property type="protein sequence ID" value="KXU37942"/>
        <property type="gene ID" value="AXK12_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="64" mass="7028" checksum="0D0D2A814C3ED02F" modified="2016-05-11" version="1">MQKTKKSVAKRFKLSATGKLMHRSPGTRHLASTKTSKQKRRLGQAKALAVGHAVPLKRCLPHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STY8</accession>
    <name>A0A139STY8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710746.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00700"/>
    <dbReference type="EnsemblBacteria" id="KXU38059">
        <property type="protein sequence ID" value="KXU38059"/>
        <property type="gene ID" value="AXK12_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="160"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU38059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="371" mass="41103" checksum="78EA29DB89E67417" modified="2016-05-11" version="1">MALNPLTLRKLRRFRSIKSGYWSFLILAGLVVLSLGGELLVNNRPLVIRYEGRWFFPTYGANLPGTTFGYDYGYETDYRALAARFHAETAEAKTRTDAPPTARSRNWLVMPLVPFNPNENAAYEGVFKPAPPSWAGGPPGHWLGTDTTGRDIFARLFYGFRITILFALGFTALTYLIGIAVGCLMGYYGGVFDLIVQRAIEIWSNIPFLYIVIILFSVVPATFSIPMRITLLLLVMVLFSWTSMTYYMRTATYREKARDYTAAAVVLGAGPGRIIFYHILPNTISTLVTFMPFTIASAITAVTALDFLGFGLPPPSPSIGELLKQGTQSLTTAPWIVGSAFAALVSILILVTFIGEALREAFDPKKFTTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU25</accession>
    <name>A0A139SU25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710770.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00835"/>
    <dbReference type="EnsemblBacteria" id="KXU37941">
        <property type="protein sequence ID" value="KXU37941"/>
        <property type="gene ID" value="AXK12_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="93"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="222" mass="23862" checksum="B06AAD77F4D74438" modified="2016-05-11" version="1">MITQLLPMAFLMNLTLMELFIHGGPIMWPILLTSFIAITVIVERIIFIIRENSSRDEEAVEAILDKAEKNDIEGAIAIGKKSGDYVARVLVYALEHRKSSFANALVRASNRELARFQQGLPTLDTVIPIVQLMGLLGTVTGMMRVFGALGEGDIAANAGQITGGVGEALIAVATGLAIAITAMLPFNYLNTRAEQAKHDLADASNALEIILHKHEAATAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU44</accession>
    <name>A0A139SU44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710792.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00975"/>
    <dbReference type="EnsemblBacteria" id="KXU37961">
        <property type="protein sequence ID" value="KXU37961"/>
        <property type="gene ID" value="AXK12_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010415">
        <property type="entry name" value="LpxI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043167">
        <property type="entry name" value="LpxI_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041255">
        <property type="entry name" value="LpxI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06230">
        <property type="entry name" value="LpxI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17930">
        <property type="entry name" value="LpxI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LpxI_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="LpxI_C" evidence="1">
        <location>
            <begin position="156"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="284" mass="30718" checksum="5035615052B0AC7F" modified="2016-05-11" version="1">MPNTPLSAFLPENFDPTRPLGLIAGKGHYPLLVAEAARRTGVAVRLIAFEGETSAELLALFPPAEREIILVGQLGKLLKTLARFGCGSALMAGQITPRRLFKGLHPDLKAAQILFSLKRRNAETIFGAIAAEIEKLGIPLLDARSFLDAHLPTEGCMTGGKFAIAPEYLEHGIQIARECARLDIGQGCVVRKGTVLAVEAFEGTDEMLRRAGQFKTEEALFVKTVKPAQDYRFDVPCFGLHTLEVMREAGIHAAALKVGSVILLDKPAILARAREAKIALLGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH86</accession>
    <name>A0A139SH86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713373.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08415"/>
    <dbReference type="EnsemblBacteria" id="KXU33919">
        <property type="protein sequence ID" value="KXU33919"/>
        <property type="gene ID" value="AXK12_08415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="503" mass="55980" checksum="30F192DE75FE43B7" modified="2016-05-11" version="1">MPGRPKVLRLLVDLEALLPGGSNGGIKPALREQFRWLGAQREQPFEFIYLCRPEVAPELRREWMRPNDRLIFAQEAAPNIAELEHCDLVYSAFGMTRWAYPGIPTVKMEVDVLHRDYPESLSEGERQHRERHFCEAVEKADLFQVNSDYTGQRLGHYYGVEPERIVRTYQPIQHRFTGYAASATGAKRPPAAPYFFYPANAWAHKNHKTLLVAYALYRHEAQCAAEPVWRLVLTGTDDESMRALRALAHTLSLEEHVDFRGFVDEATLSRLWAEAGALVFPSLHEGFGIPLLEAMSLEVPILANRATAIPEVAGDAALLVDARSPEKLACGLRQIANDAPLRAALVERGRARLTHFSLPNDFGPLIPALRALVGKSTRLKHWGYYEDRLTGPLATFALPVESQDLGTATLHYQTEPLGHPRTVEIHVDGQLVATLDIPATAPASGEIPLPMGARTLSLHTTNAARVNKADSRKLGIRLTQLEVRHALSEQIIDLLPAPRSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ9</accession>
    <name>A0A139SHJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34027">
        <property type="protein sequence ID" value="KXU34027"/>
        <property type="gene ID" value="AXK12_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="116" mass="12634" checksum="DEB9E14CC79C840A" modified="2016-05-11" version="1">MSNATSHTPFAPAQKKACRCDCASLLAVLGCFALFLLLVSLAYLPKKQGTERGPFDQDGIRTPAERLEKLAEIRANEAAAAHAYAWLDQSAGQLQIPIERAMELIAQRHSAKSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHL5</accession>
    <name>A0A139SHL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_08245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713294.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34011">
        <property type="protein sequence ID" value="KXU34011"/>
        <property type="gene ID" value="AXK12_08245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="18049" checksum="9F4E8A61AA22F4CE" modified="2016-05-11" version="1">MSSSLRAAPLSLLALAAVLVFAGLGSGCVLWTKPPPQPGAHAWFLLEADAEQEGVPLVLPVSGVAIRVAPKPVISEFDIVEAAVVEVDLGRCLGLRLTGEAARDLYRMSVSQMGRRLVLLVNGQALGARVIDGAIEGGVLFVFVEVADEELHALAREINTFAAAISAAKAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHQ7</accession>
    <name>A0A139SHQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">AXK12_07975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713210.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07975"/>
    <dbReference type="EnsemblBacteria" id="KXU34108">
        <property type="protein sequence ID" value="KXU34108"/>
        <property type="gene ID" value="AXK12_07975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="57"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="447" mass="47969" checksum="3A2A7DF12EA59BAB" modified="2016-05-11" version="1">MKTHTPPLWIRNARIIDPATNRDAPGELFVKDGCFVDSLSATDRAAATQIDAHGLVASPGLIDIQVHLREPGQVHKETIGTGSRAAAAGGFTSVVCMANTSPVGDSPATIQLIHDAIKRDAVIRVYPTGCITVGMRGEQLAPIGSLARAGIVAITDDGDCVQSNELMRRACEYAKMFDLPLLDHCQDHTLTAGAVMNEGTVSTRLGLRGWPNAAEDIIVARNIILSHYTGAHIHMQHLTSAYSVELLRDAKARGIRVTGEATPHHIALTDEALASYNTHFKMNPPLRTEADRQALIAGLRDGTIDAIATDHAPHANYEKDREFDHAPFGILGLETSLPITLSVLHREAGMSLSQVLDLMTRRPANVLKLHDGAGTLSAGAPADICLFAPDETWRYETARGFSKSQNSPWDGQELTGRVHTTICAGKIVYDQGRITADAADAASTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHR1</accession>
    <name>A0A139SHR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713311.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34020">
        <property type="protein sequence ID" value="KXU34020"/>
        <property type="gene ID" value="AXK12_08305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299248" evidence="1">
        <location>
            <begin position="27"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="318" mass="33734" checksum="AF1B75E4FC576363" modified="2016-05-11" version="1">MANLLSLLTRTALASLCTALTLNSFAQTTARLAPNENAAVLRSLPAGSKLTPATTPTELPPAWEAITLDGPFTLYVRNGDIDKGLAIKPSSPLYLEPDNAAAVVTYAAVGDAISITGLRGRWTQIELQKPLTAYVARSAAGNAAATTSDTAPTISTLPVPIPAPEETASPTASTKDATVELPEALPAETETPETLAVVDSEPIGQTEPLAQAANPPRAIDSAATTPSQINRSASAPLNRSQIQGKLVSTRKRFGPRRPYDWQINAKSNFRIAYLDFSQMQGTDQLARYEGRAVVVYGLVRPLGDDGQYVMLVESIRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHT3</accession>
    <name>A0A139SHT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07980"/>
    <dbReference type="EnsemblBacteria" id="KXU34109">
        <property type="protein sequence ID" value="KXU34109"/>
        <property type="gene ID" value="AXK12_07980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29640" checksum="B3613C7D73620A7D" modified="2016-05-11" version="1">MLGPQIVGLIEVVFVVSGLFLLVRHVLSASGRKAAAAARARADTTLLWDISSTDFLLFIFCVITGGLLAQMICSPLLALFGIDINAESDRSAATLLLGGAFHGGMLAGVAFFRLALRREEKTRTAPRSVWARGLGTLLIALPLVAASALAWQSLLRLCGIEIHEQDLVGIFAETDSALILGSMALLAVVSAPITEELVFRAGLFRFLRTRTPRWVALALPALLFAAMHANLASFVPLAVLGIVFALAYERSGTIAVPILAHALFNLNTIVMILAGLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHT6</accession>
    <name>A0A139SHT6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08100"/>
    <dbReference type="EnsemblBacteria" id="KXU34040">
        <property type="protein sequence ID" value="KXU34040"/>
        <property type="gene ID" value="AXK12_08100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="18472" checksum="7C2A579230DE8650" modified="2016-05-11" version="1">MSEANASSESLPSRNSPVELIAEAAGKFGRRPTWDEYFMATAVLISTRSSCERLNVGCVIVTAGESHKNRIVAAGYNGHLPGSPHTSRMRDGHEQATVHAEQNAISDAARRGSSVEGCTAYVTHYPCINCAKILASAGIAKICYRLDYHNDPLVKPMLAEAGIEIVQLGEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI07</accession>
    <name>A0A139SI07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713122.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07735"/>
    <dbReference type="EnsemblBacteria" id="KXU34163">
        <property type="protein sequence ID" value="KXU34163"/>
        <property type="gene ID" value="AXK12_07735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299238" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="75"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="777" mass="86582" checksum="3ED2894CBDB315E7" modified="2016-05-11" version="1">MPPKKLIPTGLVLALSCSLLSSASLFAQESPSWDQAAETVEDTYVLPTFTVESETVDRYRAADAVSAVRIRTQMIETPATISVLTKDFIEDVAPVRILDATRYSAGVQAGYHQAFADTMTMRGFESAWKTIDNFLETSGYLMEPAVIERIEISKGPNAILSAGIRPGGHVNIVTKSPQFERSTSITGIYGEWDANKFSFDTTGPLDDSGRFAYRLIGVYQDTHRYWSKDFERSRRVIAPSFTWRINPTTELVIRYNYRNTTEAHSAHAILDPSVTQRGQKPILAPGFSYRGMNGIPRWAVLNYAGGTAQAQLTSSFNEHITMRLAVFADRGGETSAVVRPNLPQLADTVTPYTGNDRYDPYTGYLTQDYVWSRQNPSLPYDEQTNPYISTFSPYYDPTNIQVRALDISAWAKTRVIQNDWVFNYELPVVKLQTVTGWAYKHREAEYRAIVGAMAPYSLYDLENQDQSVVWGNSFESNNESADRTTEIFLNQRASFWEDKIAISGGVMYYETMNSVTDKVRPSDSSRLSDSQEMYMGSALYRITEQASVYYSYSTNSIPTAANGVAMWSEGKQHEYGVKSEFFNRRLSINLAYFEITQTNVTSGNPARIAGDMNAPATLVSDQKNHGFEVEVNGALTRNLSALASFSQVKMSDQWGRDVRFVSKNLAAALLTYRVHDGALSGLSATLGAVYTGEFAGEVPSLDLTPLGVVVQPSFYIPSYTLVNAGLGYDWGRYQVRLYVDNVLDKKNYVQTGGARYGSEGLFTGAGRLFKVQATVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI13</accession>
    <name>A0A139SI13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713171.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07915"/>
    <dbReference type="EnsemblBacteria" id="KXU34189">
        <property type="protein sequence ID" value="KXU34189"/>
        <property type="gene ID" value="AXK12_07915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="178" mass="20049" checksum="4B4B768A348C15CD" modified="2016-05-11" version="1">MEQLHPYWRMDYIAAPRYPETERPFTDLPALGDDARALIVHRSRLSYVLMNRYPYNPGHLLAIPYREVTDLDQLDAAERADLSDSILYAKKLLTATLRPDGFNIGYNLGSAAGGSIAHLHAHIVPRWQGDSNFMPVIGQTRTLPQSLDTLWARLREVAATLADQNDAEPPNNDSSEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI84</accession>
    <name>A0A139SI84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712969.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07335"/>
    <dbReference type="EnsemblBacteria" id="KXU34285">
        <property type="protein sequence ID" value="KXU34285"/>
        <property type="gene ID" value="AXK12_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="290"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="384" mass="41047" checksum="079BD2B7D8521FA0" modified="2016-05-11" version="1">MRSALTALGIIIGVAAVIAMVGIGNGAKSQVEAQIAGLGQNVILIWPGTSTTGGLRGGWGSSSTLTRADAQAIANEIPGVIGVSAEMRGMAQLIANGLNWRSQVLGEEVDYLQIRSWPLAEGAMFTEQDQDRYAKVVVIGQTVVEQLFPDEDPVGQSIRIFNSPFRVVGTLSPKGFNSFGQDQDDVVIMPITSYLSRFSWQRNLSSILVQADAPEHMPRIQEAIEDLLAERRPGGRVDFTVRNQVEIAEAATATTRTMTLLLGAIAGVSLLVGGIGIMNIMLVSVTERTREIGIRLAIGARSRDVMLQFLTESVVLSAFGGLLGVALGIGLSQLMSRLNGWPTLVSTDAMLIAVLFSAAVGIFFGYYPARKAALLDPIDALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID0</accession>
    <name>A0A139SID0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">AXK12_07610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713061.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07610"/>
    <dbReference type="EnsemblBacteria" id="KXU34332">
        <property type="protein sequence ID" value="KXU34332"/>
        <property type="gene ID" value="AXK12_07610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="198" mass="21530" checksum="C176DD0DE21D58C1" modified="2016-05-11" version="1">MASPRIATLSRKTAETDIQLTLGIDGSGTSRVDTGIPFFNHMLELFARHGLFDLEVKAVGDVEVDYHHTVEDVGLVLGNAFREAVGDKLGIRRYGFFLLPMDETLARVAVDLSGRACLAYDVAAPTMFVRDFNLILVKEFARAFSNALGCNLHVTLLYGEEPHHIAEAIFKGLARALDAATQIDPRSANSLPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE5</accession>
    <name>A0A139SIE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713088.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07685"/>
    <dbReference type="EnsemblBacteria" id="KXU34345">
        <property type="protein sequence ID" value="KXU34345"/>
        <property type="gene ID" value="AXK12_07685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="227" mass="25016" checksum="DA8DF0D870713BA1" modified="2016-05-11" version="1">MSRSAAILLAAGSGRRMRGSVSDKVLAPLAQRPVFTYSAAAFAASGVADYYAVVYRDRQQLTALAAHAPTPSVLVKGGRTRQDSVMNALAALPSDIEFVFIHDCARPLIQPDQLRALHKIVRRESAVILAHRVADTVKERRDGDRFRTLKRDALWAAETPQVFSRELIVRAYQRVADRELLVTDDAAAVELLKHPIAILENTQPAPKLTTPADLAWLEYLLTRSPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF3</accession>
    <name>A0A139SIF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713023.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07495"/>
    <dbReference type="EnsemblBacteria" id="KXU34352">
        <property type="protein sequence ID" value="KXU34352"/>
        <property type="gene ID" value="AXK12_07495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="209" mass="22036" checksum="31365820421AD100" modified="2016-05-11" version="1">MTIFAAIEVFTGAGLLIYPLGLCSAVAVYILCERGFALRRAAVMPQDLVEAVIANRPLTGGRHTVLARIVEFAEAHREDEGAVRAFARLEINRMERGIPYLDVIYAAAPLIGLTGTVTGLLRVFSQISPETGLPDPVAFTSGVALALSATVIGLVIAIPALVGGGWLQRRVENYAAQLDVLLERILKNGKAATTTPLSSPVAATASRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF5</accession>
    <name>A0A139SIF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713057.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34329">
        <property type="protein sequence ID" value="KXU34329"/>
        <property type="gene ID" value="AXK12_07595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299213" evidence="1">
        <location>
            <begin position="27"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="253" mass="27828" checksum="A4DFA62442F73D90" modified="2016-05-11" version="1">MKPKLHRSLFTALLAFTVFAATAAHAAELPIITKARAYLAKDPALDAVKNLQIYGTLDLGSAGADLKEPITVEITFEKPYRQRSVIRSERGVEVTVLDGYDAWHHVVPAADKNQWSLSVLQAPQIKNLRANAFENLSFYRGLESAGGRIEDQGSATVDGQPCRKVAFIHDRDIVFYRYFNQVTGRLVMTETARGETIRESGVIETAGIKFPQKLTTTAPLPDGSRQITVINFDRIVVNGPIAADAFETPSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIQ1</accession>
    <name>A0A139SIQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712897.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34416">
        <property type="protein sequence ID" value="KXU34416"/>
        <property type="gene ID" value="AXK12_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="162" mass="17886" checksum="408F34768922B88A" modified="2016-05-11" version="1">MTLLRSLSLFSILALLGGLSFSGCQTRYKISGIAIAVTDLQPTAASTATGNHRRAVMTLRFFNDNIMPVAFAETKHKLYLEGNYVGLATNRQALGIPPAGNVEREVFVEIEKPQVLRQLAERGLSGPVNYRLVTTMRYRLGNETEHIPVQSRGQIDLTALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIQ2</accession>
    <name>A0A139SIQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase subunit GlcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712940.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00570"/>
    <dbReference type="EnsemblBacteria" id="KXU34437">
        <property type="protein sequence ID" value="KXU34437"/>
        <property type="gene ID" value="AXK12_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009339">
        <property type="term" value="C:glycolate oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004490">
        <property type="entry name" value="GlcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00387">
        <property type="entry name" value="glcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="499" mass="53898" checksum="0EA778D3A8060308" modified="2016-05-11" version="1">MSILYDERIDGALPVVDRAALLRALAAEIPDLEILSEPDELVPYECDALSVYRTTPMLVALPKRLEQVEALLKLCYARRVPVIARGAGTGLSAGVLPLPNAVLLVMERFTQILEIDPAARRARVQPGVRNVSISKACAPFGLYFAPDPSSQIACSIGGNVAENAGGVHCLKYGLTVHNILKLEILTVEGERLTIGSEALDTPGFDLLALFTGSEGMLGIITEITVKLLPKPKVAQVLLAAFDSVEKAGRAVADIIAAGIIPSGLEMMDNPAIRAAEDFIHAGYPIDAAAILLCELDGVEVDVEEDCERARNLLQNAGASEVRQAADEAERALFWAGRKNAFPAAGRLSPDYYCMDGTIPRRALPEVLRGIGRLSDEYKLRVTNVFHAGDGNMHPLILFDANKDDELERAETLGGKILELCVKVGGTITGEHGVGREKINHMCMQFNAKELTAFHAVKAAFDPEGLLNPGKNIPTLHRCAEFGGMHVHMGKMPFPELERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIR3</accession>
    <name>A0A139SIR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Addiction module antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712887.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34411">
        <property type="protein sequence ID" value="KXU34411"/>
        <property type="gene ID" value="AXK12_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="104" mass="11461" checksum="878D47939DC7E712" modified="2016-05-11" version="1">MTKTLKISSLPEFDLAEHLKTNEDVANYLTLVLEENDPAELAHALGVIARARGMSEVAKASGLTREALYKALRPESQPRFDTIMRVCGALGVRFVAEPRHSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIR5</accession>
    <name>A0A139SIR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glcF</name>
        <name evidence="6" type="ORF">AXK12_00580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712944.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00580"/>
    <dbReference type="EnsemblBacteria" id="KXU34439">
        <property type="protein sequence ID" value="KXU34439"/>
        <property type="gene ID" value="AXK12_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="412" mass="44939" checksum="89FDA7D3971CD794" modified="2016-05-11" version="1">MQTTLSQRAKGLTRADDAERILRSCVHCGFCNATCPTYQLLGDELDGPRGRIYQIKEVLEGKPASPLTQLHLDRCLACSSCETTCPSGVEYHTLLDIGRAVVDEQVTRPIGQRLLRTSLRHVVTKPRLFKVLVKIGSTLQPILPAVLQRKLPRSIPRAAKLPTTHHPRQMLMLDGCVQPAFSPNTNAAAARVLDRFGISIIPVREAVCCGAVDYHLDAQAAGLNRARRNIDAWWPAIERGAEAIVQTASGCGAFIKDYAALLKHDPAYAAKAERVSALSRDLVEILRDEPLDTLALDTRHQRLAVHCPCTLQHSQPLGGVVETVLTRLGFDLTPVADAHLCCGSAGAYSIVQPELAQQFRDDKIAALEQGKPDVIVTANVGCQTHLDSARRTPVRHWIELVDEALLPTPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ13</accession>
    <name>A0A139SJ13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferrochelatase</fullName>
            <ecNumber evidence="6">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemH</name>
        <name evidence="9" type="ORF">AXK12_07170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712816.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07170"/>
    <dbReference type="EnsemblBacteria" id="KXU34526">
        <property type="protein sequence ID" value="KXU34526"/>
        <property type="gene ID" value="AXK12_07170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="394" mass="43756" checksum="951281C394C25C5B" modified="2016-05-11" version="1">MSARRAVLIVNLGSPASTALEDVREYLEEFLGDPRVIDRPRWRWLRRTIVNRIIIPRRLKNSAHAYSQIWTKQGSPLITTSRSVCEKLAAALSRPANAPPQQADASPTRPDEAAPEQSDHALAKVYLGMRYGQPSIPEIAAQIAATGVKKVLIFPQYPHYAMSSWETVVVRVCEEFAKRAPDIRLDCVKPFYADADYIDALAAVCRPYLEARPNPAPHDHLLFSYHGIPVRHVDIASLRGVTANFVDHPLAQWTPETGGLSYVEHIKQTTEKLLLRLGGLAPRHSLAYQSRLVGEPWLSPYTDIELVRLAQEEGVRRLFVLCPAFTTDCLETLEEIQCQGRDSFLGANGDKCDSASGDAGGSLGGDSFQQIPCLNDHPAYIDFLASRVRHWAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ23</accession>
    <name>A0A139SJ23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane protein assembly factor BamA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712867.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07110"/>
    <dbReference type="EnsemblBacteria" id="KXU34549">
        <property type="protein sequence ID" value="KXU34549"/>
        <property type="gene ID" value="AXK12_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="185"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="277"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="358"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="770" mass="87500" checksum="D87BD6C39B625540" modified="2016-05-11" version="1">MGFAGLASSPLVVAQPFYQGEGREGQPEIRVGEIAVRFLGIANVSEEVVRANMQIREGRAVDDTMIDRDIRALYRTGLFEFIEVKREALPGNVFNLVVEVTPKYRVMSVSYRGNRKIKDNRLDREIKTRANASLDERQIKEDSEKIREHYQKEGYNQVSVTYAIERDRATGFGAVIFNIREGNRSKIGSIRFVGNDNIKSRKLRKAMDTRKWWWLSWLTGKGRFKDDAFEEDLDKLRDYYREEGYLDVEILPENISFSYPSPKKLLITIAVDEGRQYRIGEVEVTNATIYPPQLLKRLLRQRTGMVYSPSKLDKDVERLEDAYGTAGYLDTRVRMIRKPNITTGDIDLEYEIEESEKFSVESIAIEGNTKTKSVVILRELVLGPGDVYDTVREKISKLRLDNTRFFEDVQLSPQETNIPGRRNLRVAVREARTGNLTFGAGFSSLDRATVFAEVSQGNFDLFNYRSFFQGDGQKFRLRMQLGSRSSEALLSFEEPWLFERQLAMGFTLYRTSSEYNSDYYNQIASGGEVYLRKRLFELVDGRLSYTYEVVEIKDVTSEGLTLVQPGRTEISRVGLQILRDTRDKIIGTTTGNRVELNIDVAGGPFGGNVDYYKLDFRGAQYYPTFEFQNQVMSVMGRAGVIDSYGDSTSVPYYYSFFLGGPYTLRGFEYNDVAPRNSAGLLRGGKSYGMLSLEYSMDVVNPIRIAAFYDAGFVNPGAYDFNPSGLHDNIGVGIQLFVAGAPLRLDYGIPLSSSKQADKGGQFNFSFGTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ92</accession>
    <name>A0A139SJ92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">AXK12_07185</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712871.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07185"/>
    <dbReference type="EnsemblBacteria" id="KXU34550">
        <property type="protein sequence ID" value="KXU34550"/>
        <property type="gene ID" value="AXK12_07185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="427"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KXU34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="684" mass="76977" checksum="0FF4C08A97F1F0EA" modified="2016-05-11" version="1">MLFQLKSDYAPTGDQPQAIEKLVSSIQAGNRDQTLLGVTGSGKTFTMANVIARCDRPTLIISHNKTLAAQLYSEFKNFFPDNAVEYFVSYYDYYQPEAYIASSDTYIEKDSSINDEIERLRIAATSALVSRRDVIVVASVSCIYGLGSPEEFTEMRIELRRGENFGRDRLLERLVENLYERNDVQLKRGAFRVRGDVVDITPAYSEQGLRVEFFGDEVEAISEFDLLTGQVLRVLEHFDLYPANQYVTSRGKLEPAIVAIKTELDARVAELEAQGKLLEAQRVRMRTNYDLEMLQEMGFCNGIENYSRHLSGRAPGERPLCLIDFFPKDFLLMIDESHATVPQIGGMFNGDRARKQNLVDFGFRLPSALDNRPQSFEEFRSVTGQTLFVSATPAKFELEHSAVIAEQLIRPTGLLDPEIVLHPIKGQVEHLIGEIRAAVEAGERVLVTTLTKRLSEDITSYLREAKIRVEYLHSDIDAIERVEILRNLRLGNFDVLVGINLLREGLDLPEVALVAILDADKEGFLRSETSLVQTAGRAARHERGRVIFYADKQTDSIRRTMEVVAYRREKQLAYNREHGITPRSVQRAAQASLHVYDGSGARAGQDEESRLLAVAEGVEDREAVIAELENEMLAASRKLEFERAAVIRDQIDALCSGKGLQPDTARGSFSRKPKRTTIKPARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJJ0</accession>
    <name>A0A139SJJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712778.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07080"/>
    <dbReference type="EnsemblBacteria" id="KXU34696">
        <property type="protein sequence ID" value="KXU34696"/>
        <property type="gene ID" value="AXK12_07080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="99" mass="11045" checksum="61B29D0B599012BE" modified="2016-05-11" version="1">MTQTKRNYLATFIIDNRNNPDSLAQIVDEIKAEIAAVEGEVTAVEELGKRDFARVTDRKFTGAPYVRIAYSAPGTAPSALRERLRLNNNVYRTFIQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJL1</accession>
    <name>A0A139SJL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34690">
        <property type="protein sequence ID" value="KXU34690"/>
        <property type="gene ID" value="AXK12_07040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="70" mass="8029" checksum="DD8A613C0D6EF62D" modified="2016-05-11" version="1">MPVRFASEPNRDFEMPPPILSQRDRENTFKFGISLSRDSAMRNPKLNGCSDTLPPHAQWSRLLSQRASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJM9</accession>
    <name>A0A139SJM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06965"/>
    <dbReference type="EnsemblBacteria" id="KXU34762">
        <property type="protein sequence ID" value="KXU34762"/>
        <property type="gene ID" value="AXK12_06965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="4">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="5">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="284" mass="30005" checksum="6CCDBC2D9D1A9074" modified="2016-05-11" version="1">MAVSVANRVTVSRLETSEASEGGGIFAERESDARAQKMVAKVAARFFEECGRERFSFSYRIEGEVPRSRGLGSSVTVRAGIVAALNQLSGAGLSRDQLVRLVSELEGHPDNAAAGILGGFCVARSDPQTGHYVDTIRAAVPESLVFVTAAPLFEVSTQASRGVLPQTLPYFDAVRSINSAGYLIAAMLTGDYERLRGAVSDFMHEPYRLPGIPGAVETIAAGVRAGALTGWLSGSGSSVMCAAYREDGPRVLAAMRESFERLGQSCEAVILNADNEGLRINAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJP2</accession>
    <name>A0A139SJP2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06970"/>
    <dbReference type="EnsemblBacteria" id="KXU34772">
        <property type="protein sequence ID" value="KXU34772"/>
        <property type="gene ID" value="AXK12_06970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="150" mass="16590" checksum="229D57BE74440C57" modified="2016-05-11" version="1">MHIVLFEPQIAPNTGNIGRLCAVTRSRLHLIHPLGFEISDRTLRRAGMDYWRSLDVHEHADWAAFRASAAAPSRLWIFTTKSAQSFWSAGFADGDGLVFGNEGHGAPDWLHAEIGAAHSLTIPQRNPELRSLNLSTAVGVATYEAYRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ5</accession>
    <name>A0A139SJQ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="6" type="ORF">AXK12_06835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712692.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06835"/>
    <dbReference type="EnsemblBacteria" id="KXU34799">
        <property type="protein sequence ID" value="KXU34799"/>
        <property type="gene ID" value="AXK12_06835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="130" mass="14582" checksum="E554164A1D415F73" modified="2016-05-11" version="1">MHDPISDFLTRLRNASRARLAECSAPHSKLKESIASILKGDGYIADYTQGTDSRGHKTLVVKMKYVDGQPVLTDLQRVSKPGRRLYYRYTEIPRVLNGLGISILSTSQGLMKDQDCRRNKAGGELVCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ9</accession>
    <name>A0A139SJQ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">AXK12_06815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712684.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06815"/>
    <dbReference type="EnsemblBacteria" id="KXU34795">
        <property type="protein sequence ID" value="KXU34795"/>
        <property type="gene ID" value="AXK12_06815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="121" mass="13112" checksum="B3E26E277115D270" modified="2016-05-11" version="1">MIQLRSRLVIADNTGARKAAMIRKAGQNTDTAGIGDIVTIHIRESSTDASVKKGEVVKAVVVRTKAPVRRADGSYLRFDSNAVVIIDANNNPKGTRIFGPVARELRAKNFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR1</accession>
    <name>A0A139SJR1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">AXK12_06870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712704.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06870"/>
    <dbReference type="EnsemblBacteria" id="KXU34805">
        <property type="protein sequence ID" value="KXU34805"/>
        <property type="gene ID" value="AXK12_06870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="124" mass="13973" checksum="4721C015FB08A0AE" modified="2016-05-11" version="1">MPRLLGVEIPGHKKVAYSLRYINGIGPTRADLIVAEAGLDPNMRANDLDEEQLSKVLHIITEHKWLLEGDLRREIASNLKRLQAINCYRGIRHRRGLPVRGQRTSTNARTRKGARKTIGAKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJS4</accession>
    <name>A0A139SJS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">AXK12_06850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06850"/>
    <dbReference type="EnsemblBacteria" id="KXU34815">
        <property type="protein sequence ID" value="KXU34815"/>
        <property type="gene ID" value="AXK12_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="154" mass="16098" checksum="6C965A174627EA7A" modified="2016-05-11" version="1">MEKVVFINRCAKVVKGGRRFSFSALSVVGDGKGKIGIGYGKANEVPEAIRKSTAHANKQMVPVQIKGDTIPHEVIGEYDGGRVLLRPATTGTGLIAGGGVRAVLEAAGVKNVLTKSLGSKNHIAVVNATFEGLRKLRISEAYKNALKSEGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY5</accession>
    <name>A0A139SJY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">AXK12_06810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712682.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06810"/>
    <dbReference type="EnsemblBacteria" id="KXU34794">
        <property type="protein sequence ID" value="KXU34794"/>
        <property type="gene ID" value="AXK12_06810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="109" mass="12231" checksum="9BCBA2877E21BC9C" modified="2016-05-11" version="1">MSQHIRHNSRKTLIGFVTSRSGDKSIKVTIPYKAPHPLYHKVVNRQTVVHAHDEKNETHPGDKVEIMETRPLSRLKRWRIVSILERAASIEDVAASVAESATAEEAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ3</accession>
    <name>A0A139SJZ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_06570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712579.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06570"/>
    <dbReference type="EnsemblBacteria" id="KXU34892">
        <property type="protein sequence ID" value="KXU34892"/>
        <property type="gene ID" value="AXK12_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13342">
        <property type="entry name" value="Toprim_Crpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="830"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="950" mass="105883" checksum="17D253FF8FC6C4B0" modified="2016-05-11" version="1">MKSLIIAEKPSVAADLARALGKLPKKSDFFENDRYVISSAVGHVVELRMPEDIDKKKYGFWRLETLPIIPEKFELKPIESSKDRFALLKKLLARKDIDEVINACDAGREGELIFNYLYQLTKCAKPVRRAWIQTMTPQGIRTAFERLRSAEEMAGLGDAARCRSESDWLIGINGTRAITKRMFGSRAGNVASVGRVQTPTLALIVGRERDIRSFQPRDYWRITATFQIAAGTYEGTYQRPDFKKSDDEHDRVDRLWEKTAAEAILADCEKAPLARVSEEKKAATQAPPRLYDLTTLQREANSRLGLSARRTLQIAQALYERHKVISYPRTDSRALPEDYIPTCRDVLAQITGADLAPHASRVLDAGWVRPNKRIFNNAQISDHFAIIPTTQSAAKLDDIEAKVFDMIARRFVAVFHPAAEFAVTTRTSEIGPHRFKTEGKVLTAPGWLAVYGRSAIDEDEADSANRSGSSSKKADSAKASTGNKALPALGPTEADAKTLSAELHAEATKAPPRYTEATLLTAMETAGKLLDAEELAEAMKERGLGTPATRADTIDGLINQRYLEREGRELAPTPKAEQLLDFLTAVKAEALTSPAMTGEWEFKLRQMEQSRFARSDFMAEIVEQTKALVENVKHFEEDAASGRETTIPSPTDGLPLRETLRAYKSQDGRLSIYKVIGGRKMEEDEVATLVRDRAVGPLDGFVSAKTRSRFAAALKLVEDPETGKWKTELDFGDKVDLGELAPVWRDEKTGAELCETGPHYVLRQRKADSDEWEQAFRVGRLMCQKPITLDHAKQLVTEGKTELIQGFISKRGRPFDAYLTRDGARIRWEFPPRAPKLGKDGKPSARKPKTPPDLSAATVLGESKLHRGGELVQTADAYYVRKPDEDGRIVFEIKRSLCGRELQPEEIQQLVSDGKTGLLAGFTSKRGSEFSAYLVLSPRKSKADFEFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK23</accession>
    <name>A0A139SK23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_06460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712654.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06460"/>
    <dbReference type="EnsemblBacteria" id="KXU34928">
        <property type="protein sequence ID" value="KXU34928"/>
        <property type="gene ID" value="AXK12_06460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="477" mass="52984" checksum="16A7ADF41DF7EABB" modified="2016-05-11" version="1">MLPSVLIVDDEKHTREGLQQALEESYDVCVAANATEAFNLMDAQPFDAVVTDLRMPGKSGLKVIDKALSLSPRPAVLMMTAYGNIETAVEAMKRGAVDFLTKPVNIERLEVLIQRALRTRTLETEVKQLHERLDEKFNFDHIVGNSEKLREVIERVRLVAPSRATLLVEGESGTGKELIAQAIHQASPRSRGPLVAVHCAALADNLLESELFGHERGAFTGANERRIGRFESASGGTLFLDEIGEISASTQVKLLRFLETKSIERVGGSKAIELDVRLVAATNRDLEQRVREGKFREDLFFRLNVVRIVMPPLRERVSDIPLLLAHYLKLFAAENQVSPLTLTAGALRALQSYPWPGNIRELRNFCENAVVLHRGPELSEYDLEPKFRNAGFAESQASAASLTGEGGAKPELGVATQRHFSMAPNRLLSIEENEKRLLHEALIKSRGNRTKAAALMGVSRRTLHRKLAQWPELDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK45</accession>
    <name>A0A139SK45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">AXK12_06360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712515.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06360"/>
    <dbReference type="EnsemblBacteria" id="KXU34860">
        <property type="protein sequence ID" value="KXU34860"/>
        <property type="gene ID" value="AXK12_06360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="287"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="380" mass="40172" checksum="C12EC77264DCEA76" modified="2016-05-11" version="1">MKAENAQSREKPPPARVVIKLGTGVLTRGIGELDTERIASVCSQVAALRAAGTEVFLVSSGSVALGMGRLGLSRRPSDVVKKQACAAIGQGLLMQMWQSHFTPHGITVAQVLLTHEDLRSRDRHLAVKATLESLIAYGVVPVINENDTVSAAEIEALLRFGDNDTLSAMVASLVHAQHLFILSTAPGLIDLDGTGEIVPFVAKITPEVEAMARGTTSETAVGGMVSKLSAAKLALRAGCGVFIASGAEPDIVARLLRGEAPGTFFAPSGPTLEAKKRWLLHFQRPSGTLHINDCAVPVLRDQGRSLLSVGITHASGKFEAGDIVNVAAPDGTLIARGKATYSASEIPTIAGLKSADVKARYPDRRHHEVIHRNDLAVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK71</accession>
    <name>A0A139SK71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712451.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06185"/>
    <dbReference type="EnsemblBacteria" id="KXU34953">
        <property type="protein sequence ID" value="KXU34953"/>
        <property type="gene ID" value="AXK12_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="32685" checksum="F6E4B59F9B8F36AD" modified="2016-05-11" version="1">MLPPPTLLVLAAGMGSRYGGLKQLDPLGPSGETVLDYGVYDAARAGFGRVVFIIRRDFDAQFRNQVGAKYAGHLAVDYAYQALDALPKGYRMPEGREKPWGTGHAVWCAREQLDGPFAVINADDFYGADSFAQLAQFLQNASPENASKARAAMVGFQLKNTLSENGAVSRGICLADAQSGQLQSITEHTGILATEVGTAPSARYSGDEITSMNCWGFGAPSSAFLDGLDTELRHFLDSQGRDLKSEFYLPAAVSALIARNETTVQLLPTTSQWFGVTYREDRAQVVARIAALVAAGEYPKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA8</accession>
    <name>A0A139SKA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712473.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34966">
        <property type="protein sequence ID" value="KXU34966"/>
        <property type="gene ID" value="AXK12_06255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010331">
        <property type="entry name" value="ExoD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41795">
        <property type="entry name" value="PTHR41795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06055">
        <property type="entry name" value="ExoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033239">
        <property type="entry name" value="ExoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="209" mass="23085" checksum="96A586C391C82B95" modified="2016-05-11" version="1">MSDAPAPQKLSVELARLRDRLGNRPVTLCEVIATLRGRAYVLVVILFALPFVTPIPLPGLSTPLGLVIGFIALRQSLGLRPWLPKSWQRRELPAGFFKKTFTIAGRVIAWLERVLRPRLAWVSRPALAQQAHAVVILICAIILLLPLPIPFSNTFPAWAILLIASGNLERDGLFILLGYIASIAGLLYLLLLGTAAQKMSVSFWHWLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKB5</accession>
    <name>A0A139SKB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712354.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00155"/>
    <dbReference type="EnsemblBacteria" id="KXU35019">
        <property type="protein sequence ID" value="KXU35019"/>
        <property type="gene ID" value="AXK12_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299282" evidence="2">
        <location>
            <begin position="40"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="509" mass="55567" checksum="CB5A1B9730CCEB5A" modified="2016-05-11" version="1">MQRLLPAPTYLKRLTPRAFAQLAALALSVALLPLSPAQAALAKSAPGSTAPLTLQACIERALDKNFGLAIQRFDAANALESLTIARADYDPALTLTTGRSASQADNADTSLVGTRNDNFSTRLGVSQKIPTGATLSLSQSLNRRGTNNAFALMNPAYTADLSLSVSQPLLRGAGSRVALASIRRAELGTEIASLNTTARILQVVRDTEAAYYSLVYARESLKVRNQSLDLAQRLLAENTTRLGTGVATNLDVLQAEVGVENARRSVLLAEQTVRDAEDRLLNLIGQFEFDEALGEVSLPPTATFSPDYAISYALALKQQPEYRAATESIKQLQIDLSTARRNRLPSLDLNAAGGYNTRDASLNRAYNRLPDGDGYSWQLDLALRFPWGLRAERARYNTALNTLRREETRLRQIEQNLALDVRSAVRSVETNLASVSISRKATELSTRQYELERARFDAGLSTSRRVLEAQDDLESARVAELQAQVNLRTAMAELNRIDGTSLALYNIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKC6</accession>
    <name>A0A139SKC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712444.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06170"/>
    <dbReference type="EnsemblBacteria" id="KXU34950">
        <property type="protein sequence ID" value="KXU34950"/>
        <property type="gene ID" value="AXK12_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41878">
        <property type="entry name" value="PTHR41878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="SSF159941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="210" mass="24249" checksum="8A214587595E62B3" modified="2016-05-11" version="1">MQAWFALRFAFMISLLEGSAAKVRKKVPEKVFALRLEIVGTAPVIWRRLLVRESMWVSQLHEAIQVVFDWFDYQTHAFVFDGLRLGNPVRRDDWLVEDDRDVRLSDLNIEQLGRFGYEYHFGESWRVSATVEHVGLLEKGQVYPHCAAGERAGPPEDCGGLESFADMLHCIREPDSELGREWLEWLGESYDPQHCDLEKINKALGKLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKC7</accession>
    <name>A0A139SKC7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_00220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712373.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00220"/>
    <dbReference type="EnsemblBacteria" id="KXU35029">
        <property type="protein sequence ID" value="KXU35029"/>
        <property type="gene ID" value="AXK12_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="238"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="479" mass="51733" checksum="972AC5B3EFBB9C75" modified="2016-05-11" version="1">MRGLSEPKNPPAFQIHKRSRRIFGLSREEAIRAFFGGQALVAVVVLALITVFLFREGFGFFAQQRAELTRYRRSGVEFVDLLRAQEKAHGELGRRLGLRGEAADRFADAIVPLRALLGELGEWALEIKESEESRADGAPTRFGEVAEITAQYPKIEDTFGELTAQLGTITESSPGLSPEQRAQLEKHLSGFGATLAKLRAWDAEKPVSGWQAARSFFFGRQWLTASFWQDFYGVVPLFTGSLLVSAIALGLAVPLGLGAAIYVSQIAGARERSVIKPAIEFIAAIPSVVLGFFGIAVLGQALRALSQVEWLAWLPGFPYAERLNALTAGCLLALIAVPTIFTLAEDALASVPRALKEGSYALGARRMQTVARVIVPSALSGMVSAVLLGLGRVIGETMVVLLCAGNRIAIPDFSAGLGVVTQPVHTMTGIIAQEMGEVATGTIHYRALFVVGLLLFLIALTLNYSAQKILGRYRLPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE1</accession>
    <name>A0A139SKE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712482.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06275"/>
    <dbReference type="EnsemblBacteria" id="KXU34970">
        <property type="protein sequence ID" value="KXU34970"/>
        <property type="gene ID" value="AXK12_06275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="255" mass="28117" checksum="00594727338C9DD3" modified="2016-05-11" version="1">MKLHLLPERCGSAAENMATDLLLLQRYPTAPAAVRLRHYTWQRPAITFGYSQKYALVREQLAAIAPDGGHFDLTRRATGGGLVDHRDDWTYALVIPRGHDLEARPASQSYRLVHKALAAALTNQGVPATLKRASDTCSTPKATAQKVAPATQCFQRAECFDVIRADHSGTARAETKIAGAAQKRTKHGLLFQGSVSRAAAAGEATDWDRFYADFATELAHLLDIEVEPLGWPDFAEAELEGLIEQYSSPEWLEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF7</accession>
    <name>A0A139SKF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00305"/>
    <dbReference type="EnsemblBacteria" id="KXU35043">
        <property type="protein sequence ID" value="KXU35043"/>
        <property type="gene ID" value="AXK12_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="36385" checksum="BA3FF49EBEBB5679" modified="2016-05-11" version="1">MPNRSSTVPPALVSILIPAYNAAQWIVETLHSALSQTHPNCEIIVVDDGSRDDTLERAKAFAANASAARIRIKSQKNAGASAARNHALRLAQGDFIQFLDADDLLAPGKIGLQLAALKKHPLLTLAMGTWGRFTTDPTQTVWAEHEAVYHARSGVEFLQLKLETHSMIQPGAWLVPRTLCERVAPWEESLSLNDDGEYFARVALQAEHLLHVPEARVHYRSAISSSLSRRRSPRALDSLYRSEQLTISHLLAANDSPRSCTAAALGWRRLAGELYPEAADLARRARQAARELGAENDTPIGVPNWVSYAARLVGWPNARRLQFLRNRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ4</accession>
    <name>A0A139SKZ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712160.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35205">
        <property type="protein sequence ID" value="KXU35205"/>
        <property type="gene ID" value="AXK12_05740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299253" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="154" mass="16549" checksum="8953F78F7B315655" modified="2016-05-11" version="1">MKKLIPQLLLVLALLLSPSAPALFAQDGAGEAADTSEIPPPVAELEAIIEEFGNREASEGQASRALVDEFFGRIDQLLEKYAGDRSEGVAHVAFARAFMLFELRGDAERAIELLSAIPKDFPDTEIAAHIPTVLARLDERIAQASSGHAPDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL04</accession>
    <name>A0A139SL04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35226">
        <property type="protein sequence ID" value="KXU35226"/>
        <property type="gene ID" value="AXK12_05870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="61" mass="6938" checksum="ADB2FDFF25A4E303" modified="2016-05-11" version="1">MIVFFPAVALPAQCDVSSEAPETLACGEAFRENEYSGTGSERYIQRRDSLSDCIHYYWLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL07</accession>
    <name>A0A139SL07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35207">
        <property type="protein sequence ID" value="KXU35207"/>
        <property type="gene ID" value="AXK12_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="115" mass="12928" checksum="CADAD668A83786B4" modified="2016-05-11" version="1">MYFFFGKVRGVIAAFMLQTAHIKVVVSAASIRRISRLIGETQRFPLFKFQPQQGTVKTTTTDLLKSLRKKNRSLADEKITGPTAGDRITRAGFNRPSSLLHRVLNGVTQQVTHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL08</accession>
    <name>A0A139SL08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712242.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05945"/>
    <dbReference type="EnsemblBacteria" id="KXU35239">
        <property type="protein sequence ID" value="KXU35239"/>
        <property type="gene ID" value="AXK12_05945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="31135" checksum="A513954FC0C4E0A4" modified="2016-05-11" version="1">MTNPTTIPLITLNDGRQIPQVGLGTFGLPDEKVILRALEIGYRHIDTAQCYHTEGIVGRAVRESGLPREEVFVTTKLWNPDHGRAREALEGSLEKLGFDYVDLYLIHWPTVELNKRAEAWAAMEQARSEGLIRSIGVSNFTPPFLNEILEKGTIVPAANQMECHPTYRQEAVEAANTAAGVVTVAHTPLGRTDGVNNPVIQRVAAELGRTPAQVILRWHLQAGRVVIPKTSNLARLEENFAVTDFALSAEQVAAINALDGGSTVSTMNGEPRLADAKAFDEREGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL36</accession>
    <name>A0A139SL36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05775"/>
    <dbReference type="EnsemblBacteria" id="KXU35210">
        <property type="protein sequence ID" value="KXU35210"/>
        <property type="gene ID" value="AXK12_05775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="38660" checksum="962E39EA308CAA00" modified="2016-05-11" version="1">MTPNQNPAPSAAAAQPATATPRQKKGSSTLKTKLSPATVGAFVMGACALGIIALLSFGGMSFLSKPQRFVVDFDESIHGLDLGSPVKLRGVRVGRVADLGVRFDAQSGRAIATVICELNRDIVNDAQGQPLDLSSRAALEALVAQGLRAQLGIIGLATGLLYVELDFYDSPAAEQFASTRPDGRYAKVPALRSTISELQASLSDIFANLREVDLAALSSELLALSASVRGQVDTLDLAALSTEWAQAGAALNALVSSPEAAQLFTSLDETLADLRGVLDRLDTQLEASGAGLDTTLQEARSALEGFGAASRAAEKLMTAPNGLGEEATVALRRLSEAASAIERLADMLEENPRALIFGKKKKRPAAPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL47</accession>
    <name>A0A139SL47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712275.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06025"/>
    <dbReference type="EnsemblBacteria" id="KXU35255">
        <property type="protein sequence ID" value="KXU35255"/>
        <property type="gene ID" value="AXK12_06025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="253" mass="28214" checksum="5E767C82E24F7531" modified="2016-05-11" version="1">MRHFLTILSHEVRMLLVAPSTYVAATLFLAVMGFFFTSILQDYSNAAQEVPPPQIFFQLFWFPVLFMVPLLTMKCLAEERRLGTLETLLTTPVTTTEVVLGKYAAAYLLYLALWASTGGFFYILHRFASDLRFIDPGALIGGYLFIAVSGLLFIAIGVFASSLSRNQAVAGILGFTLLFALIFGSGLLQNASWLDRELFNPAREALHYAQIIQHREDFARGIVDTRQLLFYLSGTTLALIFSILGVEAKLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL57</accession>
    <name>A0A139SL57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-synt_1c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712063.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05475"/>
    <dbReference type="EnsemblBacteria" id="KXU35299">
        <property type="protein sequence ID" value="KXU35299"/>
        <property type="gene ID" value="AXK12_05475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="280" mass="31297" checksum="D70C4EF8E28CC659" modified="2016-05-11" version="1">MPSSPKPSTYVGRLAPSPTGYLHVGHARTFSIATERAKAADGKLLLRIDDLDRERCRPEFTEAAIEDLRGLGLHWDGPPLLQSQRLPLYRRALETLHAAGLIYPCTKTRKEIRAAAARLASTQRGPSSPPQDRTNEEQDSEPLYPLHFRPSPDSPLPPLGTHISTNWRFRTPDGDTLRFDDGAQGEQIAQVGHDFGDFLVWKKDDLPSYQLACVVDDIALGITEVVRGADLLRSTFRQQLLYRALGAQPPAYYHCELVRDETGTRLAKRRASASLRNRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL91</accession>
    <name>A0A139SL91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712273.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06020"/>
    <dbReference type="EnsemblBacteria" id="KXU35254">
        <property type="protein sequence ID" value="KXU35254"/>
        <property type="gene ID" value="AXK12_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="42"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="497" mass="54839" checksum="558486DA792450CE" modified="2016-05-11" version="1">MFSPDSFRAARWLRSCNLLLQALLFVSLFSGLNYLARSYAWRFDLTAQQLHSLSPETRAYLAGLQRPVRIVVTLSENDENPEIAQAYRDLRGLLREYSYASQNNPNGPITAEFIDIYRQHHIAGQLGLAEPNTILLLCGEARQQVALSDLYGVSERERKDFRGEQALTAAILSVSNPARKKIYFLTGNGELRPDDVDPARGLSGLASELKLRNYAIELLALPAPGGVPEDADLVIAATPQGRYDPHTQEQLRDYLSLREGRLIVLCASGIAHGLDDLFYDWGILVDDVLVRDSAASSYTDNGDLIVRHFAPHPITRTLIDYRLPLRIGAARSVRPDPGRSIGGGLEVSVLAATAPTAWGEVSYRQRGPMGYNPGIDLKGQPNLAPADRLGLVAASERVQARGNLPFSVRSGRIVVIGTGDLVANHRIATPGNQSLFLNAVKWSIDRDAQLNIPPRPIERFQLSLDQRELLKLRSLLVFALPLATAALGLIVYWSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL95</accession>
    <name>A0A139SL95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712284.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35260">
        <property type="protein sequence ID" value="KXU35260"/>
        <property type="gene ID" value="AXK12_06060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="388" mass="42353" checksum="E82BAD1BB5B2560A" modified="2016-05-11" version="1">MSASKRKLRYGMVGGGRGAFIGAVHRCAAYIDGQADLVAGAFSSEAERAKASAEDLFVAPNRAYGSYKEMAEKEAKLPAGERLDFVSIVTPNHQHFPPAKLFLEKGFNVVLEKPATFDLAEAKALKKIVEKTGKVLVLTHNYTGNVMVKQARELVRSGHLGDIRKVVAEYPQGWLSTLAEKGDNKQAGWRTDPKRSGAAGCIGDIGTHAENLARYITGLEIDSLCADLTTFVKGRKLDDDGNILVRYKGGAKGLLHASQISVGEENALNIRVYGTKAGIEWHQEHPNQLIVKYPDKPTEIWGRGNGYISDGLKKFTRTPSGHPEGYLEAFANVYAEAFRAIRAEVSGKKQPKDLDFPTIADGVYGMAFIETTVKSSKLGAKWLKFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL97</accession>
    <name>A0A139SL97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_06115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712306.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06115"/>
    <dbReference type="EnsemblBacteria" id="KXU35270">
        <property type="protein sequence ID" value="KXU35270"/>
        <property type="gene ID" value="AXK12_06115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="648" mass="71913" checksum="8F1E6590A808E8D7" modified="2016-05-11" version="1">MDTTLTQTHFTGGHEEPQIAPTRASAFWRPTAKTGLISWLTTVDHKRIGIMYAIAALFFFLVGGLEALLIRLQLAVPNNDLLSAEQYNTLFTMHGTTMIFLSIMPLSSAFFNYIMPLQIGARDVAFPRLNAFAFWTFLAGAIVINIGWLLPDGPPDGSWVGYAPLTTRAYNPDQSIDMWVMGLQILGVSSIAGSLNFIVTIINMRAPGMTMMRMPVFSWMTLITAFLIILSFPAITIALVELMMDRMFGTNFFEISQGGLPILWQHLFWIFGHPEVYILILPAMGIVSEILPCFARKPLFGYAIVVFSGATIGFLGFAVWSHHMFTTGLGTVATAAFSLATMAIAVPTGVKIFNWIGTIWGGHLKMTTPMMFALGFIWMFMMGGFSGIMHSAAPADAQQHDSYFVIAHFHYVLIGGALFALLAGIHYWFPLAFGRKVDEFWGKLSFWVIFIGFNVTFFPMHFLGLNGMPRRTFTYDGNLGWNEPNLIATIGAGILGIGIAIYFAVMVYTYFKGTKTKRDPWDGRTLEWSIPTPPPEYNFAVTPTVHARDAFWYEKHHKEEIAKEHAAHHAEEEAHGGIHMPFKSIYPLVTSSGMLIMGIGAAVLPVDAGATMRIAVSVVGILVMIGGIFMWAHEGQEGYHIHPNEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLB9</accession>
    <name>A0A139SLB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712330.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35280">
        <property type="protein sequence ID" value="KXU35280"/>
        <property type="gene ID" value="AXK12_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299303" description="Ysc84 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="106"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="230" mass="25083" checksum="F3DE65D45020546F" modified="2016-05-11" version="1">MRSPFRLLLLTLLFAAPLLGELHAALPTREDYVRRVETCEAILQEFMTSPDYGIPREVLRHAKGIIIVNQFSAGFLLGVKDGWGVIMVRRTDGTWSVPALLTAGEGSLGLQVGASANETIFILNDESTPRLLFKGRFHIGADAKAVGGPKTAANEYTLADAVAQPILVYSKNRGLYAGAAFKAGHLSSNDKANRVLYATQHSLPEILYSNWITVPDEVRPLMNYVSSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF2</accession>
    <name>A0A139SLF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711993.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05335"/>
    <dbReference type="EnsemblBacteria" id="KXU35393">
        <property type="protein sequence ID" value="KXU35393"/>
        <property type="gene ID" value="AXK12_05335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="602" mass="67781" checksum="15DD7F795AA67F5E" modified="2016-05-11" version="1">MSVPPPPSSSSNPPTSGKSPSQQKHAAPTTAAKDLRDYDEELANPPPIVDAPHVSSDELKAEAAKRAKDRPFIQRVLSTFKKEKPSYRELIINAEPLERRVALLVDGRLEKFEIERDSDTRMVGGIYKGRIKNLDPGLKAAFVDIGYTKNAFLHYWDMLPAAADSSVEVVRVNKRKNAPARPAAEPTVKDIPRLYPPGSEIVIQVTKGPIGTKGPRTTTNLSIPGRYLILMPFSDGCGISRKIEDPAERKRLKQMLNELTIPEGMGVIVRTAGEGKKTRYFVRDLHLLLKQWEKITAKTQTERSPASLYQEPDLLERTVRDFLTEEVDRVLIDDPTGFERTQDLVGQISKRSRSKISLYNDTIPIFERFNIERQIEQTFQRKVPLPSGGEIIIDETEALISIDVNTGSHKNSGGDEKNTIYAVNLEAAVEAARQIRLRNLGGLIIIDFIDMKERRHRNAIYEKMVSGMALDKAKSHILPISTLGILQMTRQRQQESLSSNLYSPCPYCRGRGIVKSATTMSVELQRKLSSVIRRLTARDAKSQHSLRVLVHPSILERIRSEDADLLIRMETLYGVKLAFRADPNYHVENYKILNATTGEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG1</accession>
    <name>A0A139SLG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712114.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05460"/>
    <dbReference type="EnsemblBacteria" id="KXU35324">
        <property type="protein sequence ID" value="KXU35324"/>
        <property type="gene ID" value="AXK12_05460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="92"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="343" mass="37066" checksum="69ABCB60E7A72CCE" modified="2016-05-11" version="1">MGGAGGAGGFRFAEPLWFLALGLLPLIFWLRGRRSVSVLIVPFSAAWAAPSLTPASRWPAALGTLGLVLLVTALARPQRVQDRHEVDARGYDIMLAIDLSGSMLAEDYEARGARINRLQAIKPVIQAFINERTSDRIGIVVFAGRAYTMAPLTFDHDWLARQTARLKIGLIEDGTAIGDGLGIALTRLEQVARQSSSGQREGAFVILLTDGANNRGALSPEQAAQIAEKRGIPVYTIGAGRSGLVPMPVLDAQGNKVGMRQVLSDLDETSLRQIAKMTGGRYFRADDNRAIRAAFTQVDQAQKIAFQAQSYLLTRELFHWPAAPGLAALLLAGLLSRRRANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH5</accession>
    <name>A0A139SLH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711949.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35406">
        <property type="protein sequence ID" value="KXU35406"/>
        <property type="gene ID" value="AXK12_05185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="127" mass="14176" checksum="1447B973ED88DB75" modified="2016-05-11" version="1">MQSKPQLLAWITCDGVHIDPSTGKHTILGAFSNIQAKHFPATHPHMVWFMTLTDCAVGEHQVQISLGQDPTAMRPLIQRGFESPSPLQRINLINEIRNLSFPEPGEYSILIEVDEEPILATSIHVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH8</accession>
    <name>A0A139SLH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712024.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05315"/>
    <dbReference type="EnsemblBacteria" id="KXU35408">
        <property type="protein sequence ID" value="KXU35408"/>
        <property type="gene ID" value="AXK12_05315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="232" mass="24463" checksum="12241E72D498F9F3" modified="2016-05-11" version="1">MSNWTAQPIHFVDFEGSLASGIVEYGVVTLIAGEVRELHTRLCAPRGRLRQADIAVHGLGEGELAGAAPVAEDFARFAAWRQSGPLAAHFAGTENTLLKSVWPYSRASPDFTRGGVGSGGAAGAAGACAEWGPWVDTGALYRQLYPQLGSYKLAELVSRCGLQAELDALAAQLCPSERCRYHAAPYDALAGALLLCALAHEPQVAALSTLQLLALSTLDGAKRDAIQQTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLR7</accession>
    <name>A0A139SLR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">AXK12_05095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711911.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05095"/>
    <dbReference type="EnsemblBacteria" id="KXU35499">
        <property type="protein sequence ID" value="KXU35499"/>
        <property type="gene ID" value="AXK12_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="134"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="328" mass="35499" checksum="45D716AD5F970952" modified="2016-05-11" version="1">MRSVLEIITASSDYLAARGIENARLNAEHLIGHALGLPRMQLYLQFERPLVERELEAIRVLLRRRAAREPLQYIVGETEFFGLTLKVDARALIPRPETEYLVSLLTERLGASEGPVTSAHTQCSPSTPALTHCPPRRILDLGTGTGAIALALAKYWEDAQVVALDASTDALALARENAERNGLADRVEFLASDWFSALASGAEARVNTPFDLIVSNPPYLSAEEVSESLAEVKNHEPAQALSPGQSGMEAFYKIVAEAPRYLRRSEASESGEGAGGRGGAGVRGGVLALETGIAQHAELAGLFREAGFAHYEFLPDLAQRPRYALAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM11</accession>
    <name>A0A139SM11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711853.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04940"/>
    <dbReference type="EnsemblBacteria" id="KXU35599">
        <property type="protein sequence ID" value="KXU35599"/>
        <property type="gene ID" value="AXK12_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="637" mass="71257" checksum="C6D4417C9B296773" modified="2016-05-11" version="1">MSDKVTHECGVALVRLLKPLSYYQEKYGNPLWGFTKLFLLMEKQHNRGQDGAGVACVKLGMPAGEPFMFRERSVEPEPLNKVFKSLLAQYDQQVQAGTVHPEFPETVKRGFSFGGELLMGHLRYGTSGGYSMLSCHPYFRRSPWPTRNLALCGNFNLTNTTELNASLTAMGQHPIFATDTQAILEKIGFSLDEAHQELYRQLRAEGLPGDAISQRISRDLDLGRVFTRSAEGWDGGYTLCGLIGNGDAFIARDPLGIRPCFYFQNDEVVAFASERAPLMTVFDLEAPQVSELAPGHVMVVKHDGSLSQTQFAAPQPRAECSFERIYFSRGNDIDIYEERKSLGARLLPQVIAAIDHDWERSVFSCIPNTAEVAYYGLMSALRERRRSEVKAAILAAHRSGALDDVLLDELILSNWPRSEKVVSKDIKLRTFIGQETLRNQLASHVYDITYGSVNPGDTLVCVDDSIVRGTTLRKSILRILQRLHPRKIVIVSTAPQIRYPDCYGIDMSQLGKFIAFEAAVELIKERGMTELLREVYDLCRAEVSGGEPARTNHVKKIYSPFSAEEISAKVAQLVSPPPNGWGGQIEVIFQTVENLRAAVPNHTGDWYFTGNYPTPGGYRVVNQAYLNFYEKTEARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM17</accession>
    <name>A0A139SM17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711871.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05000"/>
    <dbReference type="EnsemblBacteria" id="KXU35609">
        <property type="protein sequence ID" value="KXU35609"/>
        <property type="gene ID" value="AXK12_05000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="461" mass="51141" checksum="D31E9DAB10BBBB75" modified="2016-05-11" version="1">MTTLLATLLFAALAIPLAWFVARQQQTLIASKLADQEKERERLSAALTEAQAELNTLRARLAETEKTLAVERGRFAERETHLDQRLRDLEQVKAAMKTEFEAAAAQIFGEKTKTFTEQNEQRLGLLLGPLSQRIIEFRQSVEAAQKSDSTQHGELKAQLEQLRELNKTIGKEAEELSSALKGKSQVRGAWGELVLERLLESTGMRKGEEFLIQESLNTTEGEGGKSRRLRPDVILRLPEGRHLVIDSKVSLVAYEHAATASDATAREAAAKTHARAVRQHIDELSAKRYDDTGVLITPDYVLMFVPIEPAYALAIETDPALYDYAFGKRVILTTASSLLICLKAADTLWRQDRQTKNVQQIADRAGKLHEKFAGLLKDLQKLDAQLINTRETYDSAMSKLYSGRGNLHSQVAALEKLGAKTKTALPAVPETYALDEAETAELEPDDTVTRAPQTKPAVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM61</accession>
    <name>A0A139SM61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="3">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispG</name>
        <name evidence="5" type="ORF">AXK12_04980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04980"/>
    <dbReference type="EnsemblBacteria" id="KXU35622">
        <property type="protein sequence ID" value="KXU35622"/>
        <property type="gene ID" value="AXK12_04980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017178">
        <property type="entry name" value="IspG_atypical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037336">
        <property type="entry name" value="IspG_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="723" mass="77277" checksum="8B20E7D8988EE780" modified="2016-05-11" version="1">MRPRLAARVEAGTARTHEVRVGSVGIGGTNPLRIQSMTTSDTQDIDATVRQAIALAEVGCEIVRITAPNPAAAKCLGPIRKKLSEAGFPDIPLVADIHFLPSAAMEAIEHVEKVRVNPGNYADKKKFAVKEYSDADYERELQRLHEAFSPLVLRARTLGRALRIGTNHGSLSDRIMNRYGDTPLGMVESALEFLRIAESHGFKQIVLSMKASSPKVMIQAYRLLVARMAQEDMYYPLHLGVTEAGDGEDGRIKSAIGIGTLLAEGLGDTLRVSLTEDSVYEIPVARALADKGAQTRLLSGPPDSVRSTALAAKASALGATEPPSFSNLEEAPSRRDTAEFELAGGVKIGAGQVPAVIVRAASLTALGKVRAAFAAEPAHRLADTPLEGLLIPIERASEVSEVANASARGEVPSRFVVLELAPDIPTAVLAEALLAAPLPRGNVLLREFTADEGEALNALAQIARQHGLALAVALRPENVAPLADTFRELSETLPLIFTLADPHAKAGDSGPALTAYRQLAKALDRADSPKRGEGLRPEDRLLSQKKPSERLWIRNTEQSAVAPKPDFLSRLLDAATLSGALLCDGIGDMVSIETEPDPIRALKLTYNVLQGAGARTTKTEFVACPSCGRTLFDLQTTTQRIRAKTGHLKGVKIAIMGCIVNGPGEMADADFGYVGGAPGKINLYVGKQCIRYNIPQAEADDRLIDLIKEHGKWTEPSAAELPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM80</accession>
    <name>A0A139SM80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711810.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04830"/>
    <dbReference type="EnsemblBacteria" id="KXU35645">
        <property type="protein sequence ID" value="KXU35645"/>
        <property type="gene ID" value="AXK12_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="144"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="389" mass="42078" checksum="71414635C4EEDBA1" modified="2016-05-11" version="1">MSQAKKSVKVGLIGCGNRGTTVVKHLLEGAGSDQIELAALYDPRAGATAALNTKLGTAAVAQPSLDALLADSGIDWVIIASPNCHHVEQASAALRAGKHVFCEKPLATTFEDCLRLREARLAAPDRHFFFGLVLRYTPLYQKAKELLASGILGKLISFEFNETLSFTHGGYIHGNWRRYRDQAGTHLLEKCCHDIDLVNWLIDSLPVRAASFGGKDVFAPKNRHLAEAIGPDENGRPAYRGWPDPEGIDPFSEGATIVDNQVAILEYANGARATFHTNCNCALPERRMYLVGTEGTLLLNAITNTITHRKNGHKTEPETFALTAGDMHLGGDAFMASHLRATMLESKAPLAGIDDGYTSAISAFGIDQAMDSGQVVDMRGMWTRAGVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMX4</accession>
    <name>A0A139SMX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711732.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00065"/>
    <dbReference type="EnsemblBacteria" id="KXU35844">
        <property type="protein sequence ID" value="KXU35844"/>
        <property type="gene ID" value="AXK12_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1534" mass="164716" checksum="41527BC589950EAC" modified="2016-05-11" version="1">MTTSRRLLLSSTLAGFLLLLTVLLIVPGRAQQQPAAATLAELHERAAADDPEALFLLGSLYETGQAGGADLPKAAQYYRRAADLGLPHAQFNLGNMYASGHGVAADPFESILWLRRAADAGLPEAQFNLAVAYEQGHGVRADLGTAKRWYERAAEQDYPEALYNLAMMYEDGHGVAKNDTRAAELYQRAARQGYGAAQNNYGIMLAEGRGGLAANLVDAYAWLSLSSEQSGRTQGRDLVAQHLNNEQRAAATRRLAQLKSELTGEPIPTPALVPSEAPAIQVASLNESAPVAQVAAAPDARATTAHQMNQPVAVPEPRSSGVRPKPAAQPSFPRPGSPAARVAADREAQQAPSGQVAASAAAPTPSATAAAQAPIPEPRSTGRRTPPPVAVPTSRPINASAAPTVAVTAPGVSSGAVTAPVVSSGGVNTAAATSAKIKELEAANAALNDEVKRSTIQLSTLYRELTAAKDALAKAQGNAKDARPTGARQEEASSTLAELRAANAKLLAENNQLTQQVAQAKQGSRDVPTTSARQTKGAAPSSSADSRELAKLEAENKELRADLESATRTLTTLQRQTKSAARPAAGSVAQVDNTKAIAAAVEREAAKYNRRIDDLLADSRRLADENRELSQKLQSATLALSTAPASHEIEHLQEANASLTEELKRAKHAATLAREQAESRVSSVSGETARLNRRIEELNANAQKLAAQNRDLADQVQSAKLALASTVPAAELRSLEGEKDVLRAEIDRLKSERSQAQSLVATTSDEKNRISRELTELRSTNQRLSTQIEELRQQSQSAAMRLASAVPASEAQQLQSQNASLSDQLARATGELDSLRRELRETGASAETKLQLAVAAAVDAASSKHRRELDELQATNARLLAENRSLNEAKQSSSRALATSVPAEQLRLLEAEKTRLLNELRRAEQERDQIQARSSSAMLAQAENHRQIEELTATNEQLSAQTRDLEARLAAAQQSATSGAASASELQRLEREKSALLAEVSRLRTAESQLASTSTETAELNRRVQELSANSDRLLAQNRDLETQLKLAKQAVATGSASAADLRRLETEKATLAAELNRLKSAGASTETQLATAANQSAELNRRVQELSANSERLAARNRELETQVNMAKQAVALTVPVADFKRLEAQHETLTAQLARSQQTIDGLQSALAKAESTQANTAREFQTRLASAVDAEASKAHSQVEQLLASTQQLTAQNRELAAQVHTLRSTLAASVPADRLQELEAEKALAQAELDRAKNESALQLQIAEQKANKANSELSALSRQVEQLAGERQQLVNDNLALSNQVQLAQLNLAASVPADELKRIESEKALLEMNLKRMQLEHEQTQARFAEVANSANDHRRQLDELRANSNRLLSENRDLAQRLHAQEVALAAAPLPETVKKLESEKALLANALDRAKREHDLYRQLSEARAAAAKAATELASHHRENGTGGDDQLARMVETLREQNTALRQKNDRLSAMALEMANMRANAASAYATGSSAASPSDAEALRRRILELEKQLLEERVTTTRYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN33</accession>
    <name>A0A139SN33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pilus assembly protein PilC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_04150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711518.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04150"/>
    <dbReference type="EnsemblBacteria" id="KXU36023">
        <property type="protein sequence ID" value="KXU36023"/>
        <property type="gene ID" value="AXK12_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="11">
        <location>
            <begin position="291"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="422" mass="46316" checksum="A4F6D17FB507BFEC" modified="2016-05-11" version="1">MPSFAYSAIEQHTGREVSGELEARSQEAAVLELKRLRLVPLEIKRSETRKSGAGSQEVSPRPAASLKKKSAFTIGRSVRPKELAVFTRQLSSLIKAGMPFLRSLEVLERQERNRHFRLIIAALGDLIRGGGTFSEGLQQHPKVFERFYVNMVRAGEAGGVLAVVLERLAQFQEKSLRLHGRIRSAMTYPMVIILVAVSIVVALMVFVVPKFEAIFATTLKGQALPRLTQVVIGTSNFFKDHSLLAVGLTAVLAVSFRFATKSKRGIRLIDTISLRIPVLGDLLLKTAIARFARTFGTLLPSGVPILDALRIARDTSANMRIAEAITLVHDRVKEGDSVADPLRATRVFPDMVPSMIEVGEETGALPEMLIRIADNYDEEVDNSVNALTSLIEPVMIVIMAVMVGTIVIALFLPIMQIIQSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN78</accession>
    <name>A0A139SN78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711686.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04575"/>
    <dbReference type="EnsemblBacteria" id="KXU35962">
        <property type="protein sequence ID" value="KXU35962"/>
        <property type="gene ID" value="AXK12_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="189" mass="20468" checksum="3924A11625999D82" modified="2016-05-11" version="1">MLLVIDNFDSFTFNLVQYFGQLGEALRVFRNNAITPAEALALAPDRVLISPGPCSPSEAGVSLAMIAAFAEKRTPLLGVCLGMQSIGQHFGGRVIRAAQLMHGKTSPIQHDGRDLFAGLPQNFAATRYHSLAVERATLPDCLEATAHSADGELMGLRHKSLPIWGVQFHPESIATEHGLDLLKNFLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN89</accession>
    <name>A0A139SN89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36035">
        <property type="protein sequence ID" value="KXU36035"/>
        <property type="gene ID" value="AXK12_04215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="66" mass="7753" checksum="B39DD7BFDFE3EA3F" modified="2016-05-11" version="1">MFLQIENADLRSVFPYPIILKRLMAYRLSKVENLALVIQQSPSTSIFWILSMINMPTLKNIFLRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN90</accession>
    <name>A0A139SN90_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ORF">AXK12_04555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711660.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04555"/>
    <dbReference type="EnsemblBacteria" id="KXU36093">
        <property type="protein sequence ID" value="KXU36093"/>
        <property type="gene ID" value="AXK12_04555"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="268"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="567" mass="63018" checksum="F2686C5FEABED173" modified="2016-05-11" version="1">MNDDQVPSRAGNDSTPNKKGSASERPTETAEFTELSFLKRNRDRLAAIGVFLVTSVLTVLSFPPFNTSEFAYAFAAPAVFWAYLRPSFRLYAGTLLAAQAVAWCVILGWLHHVTWVGLLLLGPFVGAWIGLWYLAVWWAMPRMWTRRPLQRILVILGLAGLWALIEWTRGWVLGGFPWLPLAASQWQRSIVLQVASLTGSAGVSFLLILFNLGIAAYAHRLLRQSHQGLRKRCPEFMFALMLLIFPAFLMLGDTFRQQRVDVARLALVQPHIPQEIKWEPAHGTEIAATLEALTLEAARQWPDAILWPEAVTPWAVQGEPRARDFVSTLALRARVPLVLGSIAIEEADRADEAWFNAVLIATPEGGVSPSFYAKRRLVPFGEYVPLRPLLGWLSKVVPVGDDFARGHDPHPLILPMQRGIAVLGPLICYEDTYPQLARASVRSGAEILTVHTNNGWFGEDGAAVQHAAHAVLRAIETRRPLVRVGNSGWSGWIDEFGNVREMMADAEGSIYYRGVKTISVSRDMRWADRQSVYVRYGDWFVLMSAVLASAAGALLRLSAPPTEPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB6</accession>
    <name>A0A139SNB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTS EIIA type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711564.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04275"/>
    <dbReference type="EnsemblBacteria" id="KXU36046">
        <property type="protein sequence ID" value="KXU36046"/>
        <property type="gene ID" value="AXK12_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="160" mass="17331" checksum="D3BCE9C4AFB360EE" modified="2016-05-11" version="1">MNARLSTLLAPELVTLYLRATTHEAALREAAEPLRTHPDVGGFEPFFEQVIERERLDSTYLGNSVALPHARTAHVKRVVLAVGRSAEGLHFENCEEPVHLLFVLGTPPSSPGDYLRVVSTLCKILASAENRAALLMAASAEAFIAAIAKAEEMLFPAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC3</accession>
    <name>A0A139SNC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711650.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04525"/>
    <dbReference type="EnsemblBacteria" id="KXU36088">
        <property type="protein sequence ID" value="KXU36088"/>
        <property type="gene ID" value="AXK12_04525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="381" mass="42280" checksum="9132B3D38A058C41" modified="2016-05-11" version="1">MTTHKVGIIMNGVTGRMGTNQHLLRSIKAIIDQGGVRLSDSERILPDPILVGRSEAKLAALAARAGISRYTTDLDTALADAGNQIYFDATLTGQRPHGVRKAIAARKHIYCEKPTATTSAEALALAQEVEAAGLKNGVVQDKLWLPGLLKLKYLIDTGFFGRILSVRGEFGYWVFTGEHEALQRPSWNYRKEEDGGIIVDMLCHWQYVIQNLFGEIQSLSCLGATHIPQRWDEAGQPYKCTADDAAYATFQLANGTICHFNSSWCVRVDRDDLLTLQVDGTHGSAVAGLRDCKAQPLAATPRAVWNPDIDSPIDYKAGWSRVPTNAVYDNAFKVQWELFLRHVVKDEPFRWSLREGAKGVQLAELGLKSWAERRWVDVEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC6</accession>
    <name>A0A139SNC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711624.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36075">
        <property type="protein sequence ID" value="KXU36075"/>
        <property type="gene ID" value="AXK12_04455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8226" checksum="E41D82CF5A992B14" modified="2016-05-11" version="1">MAATEENFKDYKRVEKKALELLAEMRATNGQTVDIELALLVAIFELHKGTLPAQTIGSIIQGHLKQIIPYYAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE8</accession>
    <name>A0A139SNE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">AXK12_04115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711508.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04115"/>
    <dbReference type="EnsemblBacteria" id="KXU36020">
        <property type="protein sequence ID" value="KXU36020"/>
        <property type="gene ID" value="AXK12_04115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="97"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="392"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="416"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="649" mass="71688" checksum="D5654025D77F0A86" modified="2016-05-11" version="1">MTDQTITSVSRESRVFKPSAEFKAQANLGSEAAYKRLYAESVNSPARFWGRQAKDFLTWRKPFSQTLQWKTPHAKWFTGGMLNAAENCLDRHLGTARENKAAIIFEGEPGDIRTLTYKQLHREVCKFANVLESLGLRKGERAAIYMPMVPEAAVAMLACARLGVVHTVIFGGFSSEAIKDRINDCNAKLVITADGGWRRGKIVELKESVDRALSSSPSVEHVVVLKRTGNTVAMQEGRDLWWHELMAAAPAVHKAKPLPSEHPLFILYTSGSTGKPKGVLHTTAGYLLGATMTTHYVFDVKETDIYWCTADIGWITGHSYVVYGPLSAGATVLMYEGAPNQPAPDRFWEIIDRHGVTIFYTAPTAIRSFMRWGDEYLAKHSLASLRLLGSVGEPINPEAWMWYHKMVGKKRCPIVDTWWQTETGAIMVTPLPGVTPTKPGSCARPFFGVVPKILDENGKEVRRGEGGKLFLTQPWPSMLRTLWGDDSRFKKQYWSEVPGLYFAGDGARFDKDGYLWVVGRIDDVLNVSGHRIGTAEVESALVSHPAVAEAAAVGRPDELKGQALVCFVTLKGNQTASDELKDQLRAHVAKEIGAIARPDALRFAAALPKTRSGKIMRRILKEIAAGGDVKGDITTLEDFNVVASLQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG6</accession>
    <name>A0A139SNG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711520.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36024">
        <property type="protein sequence ID" value="KXU36024"/>
        <property type="gene ID" value="AXK12_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="323" mass="35892" checksum="4657AD09F40296A0" modified="2016-05-11" version="1">MPLIDKPLAELYTYQGLNPRPSDFDAYWDEALRELDATDPQPKLVPSTAIAPQNAEVFDLWFTGVGGARIYAKYLRPKNRAAGKCPAVLQFHGYSGNGGEFSPKLAYTGEGFCVASLDARGQGGRSEDIGGVQGSTLAGQIIRGLPDPDPRKLLFRQIFLDTAQLARVVMGFDEVDPERVGAMGPSQGGALTLACAALEPRIKRAASVYPFLCDYKRVWEMDLAYGAAYEELGRYFRTFDPRHEREEEIFTRLGYIDCQYLAPRIKAEVLMYTGLMDTICPPSAQFAAYNKISSKKDVVIYPDFGHDHLPDEADKTFDFMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ6</accession>
    <name>A0A139SNJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36031">
        <property type="protein sequence ID" value="KXU36031"/>
        <property type="gene ID" value="AXK12_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18226" checksum="8597152F0BE73F92" modified="2016-05-11" version="1">MPLGKAGYKVDVMFEVPRLPRRATHLSHLIGLRILFTTGDLSLRDALEAHPVKVRLSLHRIEDGKEVRIPLFDSKRVSGFGEYPYRYETFEIPEGIATASGYYADHSGAPEGTPNGSTRVLNLAHASTAVTPGVDRFQVETLEDIPALSGFTSFFVYEKYLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNL8</accession>
    <name>A0A139SNL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711443.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03945"/>
    <dbReference type="EnsemblBacteria" id="KXU36175">
        <property type="protein sequence ID" value="KXU36175"/>
        <property type="gene ID" value="AXK12_03945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299366" evidence="1">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="270" mass="29463" checksum="717485FD5EA95AD4" modified="2016-05-11" version="1">MKKTKRFSLLILFFTLSIGFIHAKSEADSGDNTVVFYFVRHGKTILNTLGRLQGWVDAPLTAEGRVVAEQLGRGIQREGIEFKRVYSSDSARAKTTASIVLAESGRVLPINETSALRELALGSYEGELDEKMLREVALYMGYKSGEELLEAEKTGIAVIIQALAAVKALDTLGIAEDYYDLKARAEVFIREIAEKEASDGGGNILVISHGFTIGILLSELDDEADYPTAIDVKNASVSKVSYKDGKFTIESVGDMHYVEKGSVIDAIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM8</accession>
    <name>A0A139SNM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711617.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36071">
        <property type="protein sequence ID" value="KXU36071"/>
        <property type="gene ID" value="AXK12_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="80" mass="8694" checksum="217894821FB56C29" modified="2016-05-11" version="1">MAYFRFFVALLIAALLCRLGLSAFRDYPLFGPTDIPAHSPFNNEGLPPEAISETGGNTLYRADAARGVINTQDPNIRIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP6</accession>
    <name>A0A139SNP6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Competence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711411.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03860"/>
    <dbReference type="EnsemblBacteria" id="KXU36199">
        <property type="protein sequence ID" value="KXU36199"/>
        <property type="gene ID" value="AXK12_03860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="217"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="532" mass="58344" checksum="6EDE7F7D91F63B8B" modified="2016-05-11" version="1">MLPLVCGLSLGHSGLKPSTLCAGVAIFTLFALFTVSRLRKWPRLFPLCFGCAALTVLGSAYYGYTRHFPADWDWLPPREAELELRVTRTFAQQRADRTSGIAVIAATAPHLSELVGQRVYFSLKLPGGMPPPLRSTRIEGIGVISALPSNPSPEDFAHYLDNAGVNFRFSQGQVLRTLKPASAYRQFCARMAERFSRTLGAGIEARHPLRTGILRAMLLGQKSELNEAQSWLFRTSGTMHVFAISGLHIGVIAAALHWLISLLSLPGKPRLFIELAALWLYVDITGTAPSAVRAFVMVALFLIAFVLRLPVNPIAALTASALIVICFDPLQVFSASFQMSYGIVAALLLIGLPLAESWQAAWQPYAMLPNATWHWHQRALDRVRRWGLGLLGIGVAASLVSAVTGVQFFQLFTPGSLLINLLVIPAASFAIMSGFGSLLLGLIGFELGSIAANYAALFFLSITELGIRGFMTLPQLWFQATFKAPWMGSVTLAALLLSLLIGYFRQWTGWNRFYWAPFAVLLLGFLFGVHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS6</accession>
    <name>A0A139SNS6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">AXK12_03605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711324.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03605"/>
    <dbReference type="EnsemblBacteria" id="KXU36235">
        <property type="protein sequence ID" value="KXU36235"/>
        <property type="gene ID" value="AXK12_03605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="151"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="253" mass="27902" checksum="18DA0DDA2E8D7F8E" modified="2016-05-11" version="1">MRACDFVPRRRKCVCAYDGTGFAGWQSQAAGRGLAIQDVIEARLAAIFGQPVRIAGSGRTDAGVHALGQVFHFDAAWSHGEEKLLLALRTGLPSTIQIKSTRPVRADFHARFDARGKRYEYRIHLGDADPFARPYCWTVFRPLDVDAIRAAAARLIGRHDFRAFTALNGPAREDTVRMLHRLDVLQRGRRLRIVCEGDGFLYKMVRSLVGALVSVGEGKLSAADLAAILASRHRTATVQTAPAKGLFLAKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU1</accession>
    <name>A0A139SNU1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711362.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36255">
        <property type="protein sequence ID" value="KXU36255"/>
        <property type="gene ID" value="AXK12_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="86" mass="9375" checksum="35502510FAC8365F" modified="2016-05-11" version="1">MTAPKKTVTPLGVAIDLILVAGFFLFLFNVVQSHVPSNNPQMILLWSALSAACLSGTFWIAIQMFRVVLKAQLARNSGTDSPDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU8</accession>
    <name>A0A139SNU8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">AXK12_03600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03600"/>
    <dbReference type="EnsemblBacteria" id="KXU36265">
        <property type="protein sequence ID" value="KXU36265"/>
        <property type="gene ID" value="AXK12_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="176" mass="19093" checksum="7764C48FB97CCBC2" modified="2016-05-11" version="1">MQKKFLSQRKIFLWGAVTDTTAKDLTEKLLYLEATAPGEAITLYINTPGGSISAGMAVYDTMQLISSPVTVVVTGMAASMGSILLSGAAKGRRLLYPHARVLIHQPLISGHFSGPATDINIQAQEMEKLRAELNQILAKVSGQPLERIEQDTDRDFYLNAQEALAYGLADQIVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP29</accession>
    <name>A0A139SP29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_03360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711247.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03360"/>
    <dbReference type="EnsemblBacteria" id="KXU36338">
        <property type="protein sequence ID" value="KXU36338"/>
        <property type="gene ID" value="AXK12_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="438"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="730"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="851"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="976" mass="106612" checksum="B915A809FE29FC59" modified="2016-05-11" version="1">MIALFKSLRPRSFAQKIQWAIGLVIAAVLLVAGTFDYLSSNRLIQAQTQSTAFGHIESIAKELDGVISAVGNLPRSIAAFQETLGSTSDPAIDGFLRALIRDTPADQVYGVYLAFESLPASAPRSSLRINRKTYPEIVALNYDYHSPLYEWYHGPRRTGRLHITEPRQNSDGHTTRMVNVSAPIRSEDGRFIGAAAASIPLTSLLPTVRSRGFEGGQSHTNDDSEYTYIVSQDGNIIAHPDETLMLGDDGVSPSNIADLVAGPYVSSAPRGHARIEVEGEPRLLYWIQAPHSGWKIVLDVSEEKIRSPIDRLALRDILIVAAALLLTFIVVSYIARRMTAPITWLKSAAHALEHGEFSPDSLDPIAARTDELGELAHSFQNMARTITQREQSLAELAENLEQTIQSRTAQLAQAVTDAQNARAHAEQANQTKSEFLANMSHELRTPMNAIIGYSEMLIEEAEAAKKPHVVADLQKIRNAGKHLLDLINDILDLSKVEAGKMPLYIEQFDVREMLNEVVTTISPLIEKNQNTLDLHFADDLGTMKADVTKVRQTLFNLLGNATKFTEKGTVTFEARREVVPADSDTAPDGQSGSLSERLVFVVHDTGIGMTPDQLSRIFEAFMQADSSTTRKYGGTGLGLPISRNFCLLMGGDLLVESEYGKGSTFTIVLPAKVSRKTANTQSLGGDTGDDDDASESGSENDDATDSGAVSVTKGSSLADAAQATAPDGATILVIDDDPVMRDITSRNLTREGYHVLLASDGPKGLAIARAEKPAAIVLDILMPGMDGWAVLSALKKDPELRPIPVILASQLDEKEVGFALGAHDYLIKPVDKDRLVTAIRRHLDDPGDARPLLLVEDDKTTREMVQRLLEKEPFTIDTAEDGRAALEHLEHAQPLPAVILLDLLMPTMDGFEFLTRLRERDEWRGIPVIVLTAMDLSMAERDTLLTRAKYILPKASTGKVELIDKIRAALEGEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPU9</accession>
    <name>A0A139SPU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36481">
        <property type="protein sequence ID" value="KXU36481"/>
        <property type="gene ID" value="AXK12_03175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="31596" checksum="864A557E0230E7E5" modified="2016-05-11" version="1">MLDAAHVTEADLAAAAEAFHRDGYFIARGNFSPEEIEELNSTFMKMHADGGVPGFYEPGKLDGWRDEDDRADNKDQVDPLAVWPRVMHAHRFNEKARAYFLHPKIRVYIEKFFGGEPVGTQTMYYFKPPGARGQAMHQDNFYILVSPGTCMAAWTACDDCDAENGGLMVVPNSQNTDLVCPDIADLNISYTPHKVPIPKGLKPIPAHMKAGDTLFFNGNVIHGSGPNRSKDRFRRSWICHYAKGDIAKISEYYAPVVTMDGRDIMVESEKNGGPCGGTWKGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ88</accession>
    <name>A0A139SQ88_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpD</name>
        <name evidence="12" type="ORF">AXK12_02790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711138.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02790"/>
    <dbReference type="EnsemblBacteria" id="KXU36702">
        <property type="protein sequence ID" value="KXU36702"/>
        <property type="gene ID" value="AXK12_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="147"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="472" mass="50863" checksum="F50E0EE6746CFCE3" modified="2016-05-11" version="1">MSNTGKIAQVIGPVVDVQFSENEIPPIYQALSVEFEAAGKPERLTLEVQQHLGGGLARAIAMSSSEGLKRGMEVEDTGAPISVPVGEGVLGRIFDVTGTPVDGRGPVAYQKKYPIHRAAPSLADQDTNAEILETGIKVIDLIAPFTKGGKVGAFGGAGVGKTVVIMELINNIAKAHGGYSVFAGVGERSREGNDLYHEMSEAGVIDQKNLANSKVALVYGQMNEPPGARMRVALSALAMTEYFRDEKNQDVLLFVDNIFRFSQAGSEVSALLGRSPSAVGYQPTLSNEMGQLQERITSTKKGSITSFQAVYVPADDLTDPAPANTFAHLDSTIVLERAIAEKGIYPAVDPLASVSKALEPGIVGEEHYHVARECQRVLQRYKDLQDIIAILGLDELSPEDKQTVFRARKIERFFSQPFHVAEVFTGSPGKYVSVKDTVRGFKMILDGELDDVAEGDFYMKGSIDEVLAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD9</accession>
    <name>A0A139SQD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711182.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03060"/>
    <dbReference type="EnsemblBacteria" id="KXU36747">
        <property type="protein sequence ID" value="KXU36747"/>
        <property type="gene ID" value="AXK12_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="404"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="851" mass="95270" checksum="29B89D414631466D" modified="2016-05-11" version="1">MTAHNPLIRAWLSSLKSGYIEYAHDWGQVDVPAVRLRGGEGVEATPLFARLEFAPRHAAARRYGYFVREDGALVFALPSAAVPEGERVFVSGDFNHWQGAGDPVWELKPYADSSEAEGKYAASGAAAQGFSEVEPDLRPLCCCVVPPARRRAAMRKLRDGRRVQFKFVTGEQLWLNVPEDSPNRVADELGHFNYQIDVQRTGRQFFKFTLRWPLDLSQRWWVAPLALGGLEAGVPLEPGNFFFSLASELPLGAMVEDGQTYFRLFAPRASAVRVLLSESPEPSAPAEVVSLERLGSQPYIWEACVEGNLHGRYYWYQLLGEVGGDKSASAGGGERGARVLDPYALACVGREGPGIVIDRALLARPGLAEHFSTPQWQDLVIAEAHVRDLAAQAPIELSAEERLGFSGLRKWVESEDFYLQRLGVNCVELQPVQEFDNCTREEYHWGYMPVNWFAPASAYALDPARASGIRELQDLVLAFHRRGIAVVLDVVYNHQGVPAGLAAIDRQYYFEHNAQGELSNWSGCGNDLRAHAAMAKRLIIDSCRHMIECFGVDGFRFDLAELIGVDVLREIEHALKKVKPDVILISEPWSYRGHIAGALRDTGWSSWNDGYRDFVRDYVRGGSLPETFEYFIKGAPWFWAKWPAQTVNYSESHDDRAWIDVITENPDHNGSVPTLNDRRRTHLMAALLFASLGIPMIAAGQDFLRSKGGVSNTYQRGDLNALDYRRLLRYPATHAYFADWIAFRRSEAGRFLRQWRLPSAGFFRFYHAPNSTACAVVYNFDASQGRQRLLFAINPTGAEVEIPLGEALPTVSRWTQIANHECFLGANGVRQPLTSRLWLPALSCGLWQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR34</accession>
    <name>A0A139SR34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37018">
        <property type="protein sequence ID" value="KXU37018"/>
        <property type="gene ID" value="AXK12_02405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="46468" checksum="274FFC3133C16254" modified="2016-05-11" version="1">MQRDSRAPVGRTRASEPVPKKSVCDSGFALVLVLSLVSLLMAAVYTISLISKVDAEIGATDAYRLQARQNALLGLGLAIAELQRAAGDSAAVTAPATLRLTNSTTLAYPSLTGVWSAGSFSENPDNWFVSGNFEELGPNQITPAVLPPESSAITLIGNGTVSATRDMARALRVPIADTNGGYAFWVGDEGAKAALAILPADSPLAPNGAPLVIDPRRDIPSFAHNSPVRAQPFLWNDLRRLVGSTNMKARFRSYTTKAQWVEGSALVGGRFNINTSNPISWEAVLRAYENARDPSQPELSAAKAQALAERLAANIGPKQWANAKPQFGPFFSLAAFWDSELVQESLEDAGITTLTQGDLHSILWPMLAVRSDTFRIRAYGDARNPADFANPTAPPQAAAYCEVIVQRTPHPDPLGNGLRFEIVYFRWLGAADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRC6</accession>
    <name>A0A139SRC6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_02235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711036.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02235"/>
    <dbReference type="EnsemblBacteria" id="KXU37082">
        <property type="protein sequence ID" value="KXU37082"/>
        <property type="gene ID" value="AXK12_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="409" mass="43547" checksum="5873A2CA14001C51" modified="2016-05-11" version="1">MRGIREAFPILHQSVNGKPLVYLDNAATTQKPRAVIDALVHYYERDNSNVHRGLHALSMRATDGYEGARARVARFIGAADPCEILFTRGTTESVNLVAQTWGRANLRPGDVVLATEMEHHGNLVPWQELARASGATLRLVPLLGENGEGGLDLAALDSLLTPQVKLFAFTHVSNTLGTINPAAQLCAKARAVGALTLVDAAQSAGHQPIDVQAMGCDFLAISGHKMCGPTGIGALYGRRELLEKLVPYETGGGMVATVSYDGATWKPTPERFEAGTPNIAGAIGLAAACDYLDSVGREHIAAHCHELGRIAYERLSELPGIRLLGPAAGAERSGIVSFALADVHAHDVVTFADEDGLALRGGHHCNQPLMHKLGLTSTTRASFALYNTAGEIDTLVASLRRIQKFFAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRM0</accession>
    <name>A0A139SRM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">dnaK</name>
        <name evidence="9" type="ORF">AXK12_02285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711045.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02285"/>
    <dbReference type="EnsemblBacteria" id="KXU37091">
        <property type="protein sequence ID" value="KXU37091"/>
        <property type="gene ID" value="AXK12_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="651" mass="69709" checksum="E1C10E2B18F0DE2E" modified="2016-05-11" version="1">MSRILGIDLGTTNSCMAVMEGGEPVVIPNAEGARTTPSIVAFTKNGERLVGQAAKRQAVTNPRNTVFSAKRLIGRKFSEIQEEVKTLPYKVVAGKNGDAFIEVQVADKTEQFAPQQISAFLLAKLKADAEAYLGEKITQAVITVPAYFNDSQRQATKDAGKIAGLDVQRIINEPTAASLAYGLDKKRDEKIAVFDLGGGTFDMSVLEIGDGVFEVKATNGDTHLGGDNWDDALINWLVDEFRKENGIDLRNDPMALQRLKEEAEKAKIALSSAQSVDINLPFITADATGPKHLNVQLTRAKMEQVCDSLFERCRPPFQNCLKDAELSSSQIDELVLVGGMTRMPKVVEIAKSLAGKTPHQGVNPDEVVAIGAAVQGGVLKGDVRDVLLLDVTPLTLGIMTAGDVATPMIPRNTTIPSKKTQTFSTYSDNQPSVEIVVLQGERPMARDNKTLGTFKLDGIPPAPRGTPQIEVTFDIDANGILHVSAKDLGTGKDQKITVQGSSGLSQEEVERMTKEAELHAEEDKKRKEAVETRNQLDSSIYQLEKTLGEAGDKLPAEKKAPIESALADAKKALESDDAAQMKAALENLSKVGAELYAEAQQAAQAAAQAGGAADASSAGASSAADSGKRPEKQADVVDADFEVVEDDKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS47</accession>
    <name>A0A139SS47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01830"/>
    <dbReference type="EnsemblBacteria" id="KXU37367">
        <property type="protein sequence ID" value="KXU37367"/>
        <property type="gene ID" value="AXK12_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299408" evidence="4">
        <location>
            <begin position="33"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="35127" checksum="6040064DF2A37F74" modified="2016-05-11" version="1">MTTTTKCPKPSVAAVLKCAARAAMLLFLGLVAACTPHQDDAASAAANSAASTKAPSAKLRVVTTFTILQDLAQNVAGDCAVVESITKPGAEIHGYEPTPQDIIKAQQADLVLWNGLGLELWFERFFVRLKDVPSVVLSAGVTPIAIAEGPYSGRPNPHAWMSPRAALVYIENVRAALVAHDPANAATYNANAAAYGAQFAAVEADLRARLSRIPAAQRWLVTSEGAFSYLAHDFGMKELFLWAVNADQQGTPQQVKKVIDAVRANAIPVIFSESTISDKPARQVARETGIRYGGTLYVDSLTAADGPAPTLLRLIGYNAEVILRGFNLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS59</accession>
    <name>A0A139SS59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ligand-gated channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_01810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710949.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37435">
        <property type="protein sequence ID" value="KXU37435"/>
        <property type="gene ID" value="AXK12_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0798">TonB box</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299354" evidence="10">
        <location>
            <begin position="25"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="12">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="11">
        <location>
            <begin position="234"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="713" mass="79717" checksum="7F6DBF565315340F" modified="2016-05-11" version="1">MNLRNLHFAQAVFRNALCCALLCAAVPLGWGQAALQEDASPIQLDALEIVADVLDRDDSRQKVVSTATKMAMDARDVPQTINTLEMSKYKVYGLNDLSVLLDGTPGLDTSYDMRSDGITIRGFAADSNDIYRDGVRNAGQIRRGTANVERIEIVKGPASVLYGRGLGGGVVNLISKQARFDAVSSIGVRGGSWENRGATVDVNQVVTDNVVVRLTTDFEQSDSFRRGISNRNRMFSPSILIDNKQGLSWLAQYTYDKVWRRPDRAPAFDALPEGVSSRTAYAHPDDFVEDIAESIRSELNYAFNSNWSLKWTAAWNESAQDFDHLYAGRYNPTKGTMTFTRAWQETSNTTFINTIDLSGHFNTGPISHTLLFGGEASREKRLPNLATSGASSDPGLLYPWEIDPYDPVFIESKTPRGEAKTSNRHRATSEALYVQDLMSVGEHWKVLLGGRFDRFHFRSHNLITDKQRGYRGDTFSPRVGVIWQPSESQSLYVSYSKNFAPYGGRGLMSVSVDDTAVYDADPQYSRQYEVGIKSEWFDDRLSSQVSVYELELYNIRYRPDPDNDPFLWAVRGSERSRGAELSLTGKILESGLYVRSGVGLQEAKIIEDKSTPANEGRHKRGIARKTGNLFLRYAPKSPFYAEIGVTYKGPIYNDLANTSQRSGYTRWDASVGWRVMPWTVTLAMTNLAGKDYWRSSSMPGAPRSFLLSANYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS68</accession>
    <name>A0A139SS68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710952.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01790"/>
    <dbReference type="EnsemblBacteria" id="KXU37439">
        <property type="protein sequence ID" value="KXU37439"/>
        <property type="gene ID" value="AXK12_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Mg_chelatase_C" evidence="2">
        <location>
            <begin position="409"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="512" mass="55460" checksum="5512FC1FA56500C7" modified="2016-05-11" version="1">MLASIHSATLQGIVAAPVQVEVNSGESGDPRLVLVGLPDAAVKESEDRVHSALSNSGFAMPETRTTINLAPADIRKEGPLYDLPIALGILLSTGQLTPVLNPADYLVAGELGLSGITRPIRGALAIAQLARKLGKTGLLLPPRSAEEAALVEGIAVYRVESLDQAHRFLSGTLALAPLRGDRHFLRKSDSALSGDFSEIKGQHALRRAVEVAVAGNHNLLMIGPPGSGKSMIAKRIPTIMPEPTLDESLEILSIHSAAGRTISGEAPWCERPFRSPHHTISDVGLLGGGTMPGPGEISLAHHGVLFLDELPEFKRSALEVLRQPLEDGEVTISRSAGKVTLPCAFMLTAAMNPCPCGYLGDPQHECRCSPIQIQRYRSRISGPLLDRIDIHIDAPTLSIRELRTESASESSVAMRERIQAARTRQHTRFAATRTTSNARMTHTQIRQFCRIDSTLGDLLQQAMEQLSLSARAYDRILKVTRTIADLAGSEHIEPPHLLEAIQYRSLDRKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS76</accession>
    <name>A0A139SS76_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">AXK12_01915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711000.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01915"/>
    <dbReference type="EnsemblBacteria" id="KXU37382">
        <property type="protein sequence ID" value="KXU37382"/>
        <property type="gene ID" value="AXK12_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="108" mass="12285" checksum="47880BBEE1BFC5C6" modified="2016-05-11" version="1">MTVIVETSPVTHPESDTLTERAPARRWLVVVLNDPVNLMSYVVMVFRKVFGFDETAARKHMLEVHEQGRSVLWSGPREQAEAYAYTLQQWQLTAVLESEEGDDGYASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS93</accession>
    <name>A0A139SS93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710942.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37428">
        <property type="protein sequence ID" value="KXU37428"/>
        <property type="gene ID" value="AXK12_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="20389" checksum="FBABD7DF81DB6826" modified="2016-05-11" version="1">MNHFTFTQQFREIYDRALALYAEGRRGAENYFTPEELAFLTANGITAQHIYDYVEDQHNEDVPGYDTALSIEIIRRDYFLNVQNGQWTGKKEDPETWPAKPESLAGIVWLPRILRKVRAKLRGELPDSAMFCCGGDRRFFKANNIHPSEFINLAWRAGDDDQPIIDFVVARSKTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB7</accession>
    <name>A0A139STB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710831.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01180"/>
    <dbReference type="EnsemblBacteria" id="KXU37805">
        <property type="protein sequence ID" value="KXU37805"/>
        <property type="gene ID" value="AXK12_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="188" mass="19643" checksum="36FC85E85C1A9A03" modified="2016-05-11" version="1">MNPVLKLLMESSGGGVAASAATSALGSVAQLAQLAGLSEAEVKAQFDELKTQGVFLGWRPVLDWARVSAASGSASAGEGGAAVAQGTVRAVIEVRLTPERGGGFNRLAKRISLFDEVESCFLMSGGYDLLVFVKGQSMQKVAGFVSEKLSTISGVLSTSTHFQLRCYKDQGFVLDPDQGEAERLSIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD9</accession>
    <name>A0A139STD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD</name>
        <name evidence="3" type="ORF">AXK12_01405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01405"/>
    <dbReference type="EnsemblBacteria" id="KXU37847">
        <property type="protein sequence ID" value="KXU37847"/>
        <property type="gene ID" value="AXK12_01405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="291" mass="31127" checksum="4D7ED15D08C3F34A" modified="2016-05-11" version="1">MVATFDKPTYSVRRTRRKEIGHGLYIKDPVSGETLFTKDVVENQMVIPSSGHHLPIGARERLGFLMDEGSFVESDAKLRSADPLGFKDSIAYPDRLRKYEKASGLSEAVICGVGAIQGIEVAIAVMDFRFCGGTLGSATGEKITRTIETAISRKIPCIIFSTSGGARMQEGILSLMQMAKTSAALGRLAEAGLPYISVLTHPTTGGVSASYATLGDVIIAEPGALIGFAGPRVIKDTTKVTLPEGFQTSEFLLNLGLIDLIVPRPQMRAQIAALLQALYVGKRPEAEAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STE3</accession>
    <name>A0A139STE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalamin biosynthesis protein CbiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710876.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01340"/>
    <dbReference type="EnsemblBacteria" id="KXU37846">
        <property type="protein sequence ID" value="KXU37846"/>
        <property type="gene ID" value="AXK12_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="236" mass="24164" checksum="9AABE86C06608CBE" modified="2016-05-11" version="1">MHIPDGFLSPATYLSAGAVAVGGWAWAGRGLGSRLEAEAVPRLAVLTALAYGLGLVMLPLPGATSGHLIGVPLLALVFGVRQAFLAYSLVLLLQSLLFGAGGITALPVNALVIGLLGALTARGVFSALRRVSEAGAVMLAAWCAVVISAAALGAILGLQPLIAHDAQGRPLFCPFGWAVVLPAILLPHLLIGVAEAALTWMVWCFAKKRGWGLAAAQRSAKKTTPTAPSPSPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STI8</accession>
    <name>A0A139STI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01110"/>
    <dbReference type="EnsemblBacteria" id="KXU37792">
        <property type="protein sequence ID" value="KXU37792"/>
        <property type="gene ID" value="AXK12_01110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29435" checksum="1B0DBFAD748D9A17" modified="2016-05-11" version="1">MRICVKCLSGDVARHPLFPMIDAPKSPQSNAAKNAEKQPAASSATAGFTLIELLTVIAIIGILAAIIIPTVNGVRARAQRSVDGSNLRQVIQAALTYAADNNDRLPNPDVPGLLSATENVFLWPGLLARAGSLNEPSMYFSQVDPAFDGTMPPTILNPQNRNLVDAAFSTGRELSWEFVGGLRMSDPATTPVAFTRGLLPTGSWDPANGVYGDTGGYVVFLGGNVEFFSDTASAKFINTQTGQRTDNLLEALPRRPGIKVWATSRGGIGLPSGTPAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STM1</accession>
    <name>A0A139STM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transporter ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710768.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00825"/>
    <dbReference type="EnsemblBacteria" id="KXU37939">
        <property type="protein sequence ID" value="KXU37939"/>
        <property type="gene ID" value="AXK12_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="146" mass="16289" checksum="A6CF9FDA4A0BDAD3" modified="2016-05-11" version="1">MTGNDSSGGPKKARIEIIPLIDVIFFLLATFILFTLSLEKIQSLPVELPKAAPPSAATSQEDETVTLQVSEFGNCYWTHRKTTELIDVSDVRPRLQNYKANTADPRVLITTDDRAKFSLAIRVLDEVRLADIDKVSVETRVRTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN2</accession>
    <name>A0A139STN2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710765.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00810"/>
    <dbReference type="EnsemblBacteria" id="KXU37936">
        <property type="protein sequence ID" value="KXU37936"/>
        <property type="gene ID" value="AXK12_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="181" mass="21210" checksum="3D0516B6D71E5B9E" modified="2016-05-11" version="1">MKKVHVLFPLIAMILFGGYWWNYNKQYEAEQEAKKERDRQALVAKREKEAQDRELAIKLAIEKQAEQRREREIREAKRQKEREDRQTAREARERADRERQKLRRQAELLDQDIVKETEAVAKLEERKQYLLAEEGFLQEYVRKAESNEGGITEVIQRIAAAEAARAAAAAEAAQASSRRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ9</accession>
    <name>A0A139STQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710847.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01270"/>
    <dbReference type="EnsemblBacteria" id="KXU37821">
        <property type="protein sequence ID" value="KXU37821"/>
        <property type="gene ID" value="AXK12_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299460" evidence="6">
        <location>
            <begin position="24"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="339"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="748" mass="83416" checksum="963DCD9E414F2266" modified="2016-05-11" version="1">MKSPKLLPIALSLCTFALGSLHAQQTPDQSDEEIVRLSPFSVQESADVGRYQAVESTSGARIRMDLMDSTQSISVVTNEFLNDIGTARLNDAMKYVAGISSNAQPNALDIMSVRGFVSLGATLDGFNQFNWINQDPIIIDRIEVVKGPNAILAPQGLPGGVVNNITKKPLFTNKGSVSYQVGRWDADRAEFDANYVVRPDKLAVRVVGAVTDSDDYGRGEFHQNITVMPMFTYRVSQSTELTVQFHAYNASLTANNGVPISLYAVNRSNVWLQDGLPRDFQILGRNISRHQNGQNTRFFLTSQITDKLSMRLVGNQIEQSTRTNFLGPTAALDVNGTPGEVITLDPITGQWSWDGVTRNDSPRYRLGGANEWPKITHANLQNDFVYEHSGLSWKSQTVAGYAINYHSQHQRIKNYVADPTLYDLTDNFVPPPYTLEADWRDNWSSRNRSNQVYVYEVLSLFDDRLVLSGSLSQNRYFGEGINNLTGARTENKGEATLPSGGVVYKITPGISVYYGFSKQELLGGSDEDAGIPPHTVPSRQHEGGIRVKLFDGKLYATLAYFDILQENLYEQNFANYVQPRPVPPLPPVLAERTSKGFEFELTWAPTKNFSLIGSYTDYESRDRDNQRYTNAPERMAAAWASYTFSETGPLRGLSVGVGASYVGERPSDTIGQYTSPPPGFTPARIQPSFWLPSYTVVEASASYRFNEHWKAQLVIKNLLDEDYIIGSFNRSIFVSTPINPKLTLRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU58</accession>
    <name>A0A139SU58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710741.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00665"/>
    <dbReference type="EnsemblBacteria" id="KXU38054">
        <property type="protein sequence ID" value="KXU38054"/>
        <property type="gene ID" value="AXK12_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU38054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="561" mass="60083" checksum="1CE87174BA48E829" modified="2016-05-11" version="1">MLPAPVVESYSEVDIHGLGTAVLEEDAPNFFGEVIISGAQLTLKDGGRLTNAWRVLVKNGGTLFLDNSAAAHGDRLGSTAEIRLNAGTLAFAPGDFGFLTQELSYLTLSGGANQIDLHLGSTSGGLLLAQELSRAATSTLNIRYIDPTNGSAAPINVRLEVQNWSIFTQLDILPWATITHGSQVDWAPWKAGGIVFNPFTNYYTGSPANWNTVHNVLIDSSTTTLNNPGGVTWVRSLKLANGGALILGGPGNSQILDLDSGGLLSTGSAGNQISGVGEIRLGFDFFNALLIHVHGGNLSVSGTITLDSILAPIIKTGEGTLRLNGDIWMQGGPLVINQGIVSFEKGKGMDFMTVLIGDGTGTDVLELPASHDNPITSSWDPSGWPSIVLHGTPYSTSPGSGAADAAILRFRGGTVQNAQLLHVEGRGMLDFLGGTVAKPNMLYLEEFTLADFDTTLLFIRHWEDGRDILLAHREKNKDRIDADFLARIKFEGYDAPAEWVYWGDGTYWEIRVAPEPHTYGAILGALGLGFFVWRKRKRGSANAASVRSTREWRAASQMPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH61</accession>
    <name>A0A139SH61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000066">
        <property type="protein sequence ID" value="KXU33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713387.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00630"/>
    <dbReference type="EnsemblBacteria" id="KXU33899">
        <property type="protein sequence ID" value="KXU33899"/>
        <property type="gene ID" value="AXK12_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="PTHR41729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="199" mass="22093" checksum="42A4B4F75A6F8488" modified="2016-05-11" version="1">MSSEITDSYDKARALIDAAHAADPTRAEDGRAAELVYADRVEAWVARLVPDAAPALLLAARCQHLERFLTPRHSYPEGRVGYLKWRQFLYKKQAERAHQLALEAGLAPTEADQIARWVSKTDLRKDPGSQALEDAAILVFLENEIGAFAAQHADYTREKFIDILRKTWRKLSPAAQPHARALALPPAIADLIHAALAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHA8</accession>
    <name>A0A139SHA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000066">
        <property type="protein sequence ID" value="KXU33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00640"/>
    <dbReference type="EnsemblBacteria" id="KXU33901">
        <property type="protein sequence ID" value="KXU33901"/>
        <property type="gene ID" value="AXK12_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299273" evidence="7">
        <location>
            <begin position="32"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="320"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="443"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="533" mass="56176" checksum="3E81B9E148EEF5C7" modified="2016-05-11" version="1">MNTPAPIKRFTTLLLALAMLAVPALAPNLHAADNNKAAAAKTEKTPKPKRTKGKADTPEPRDALALQIDATPIDRDDALRVSYSGVVQKAAPGVVYIFTTKFLKPRPELAPFFNDPQFRRFFGIPDSDGEGQGSGSGRGGQGGRSAPTQRAQGLGSGVIISRDGYVLTNNHVVDGADEVRVAYGEPRRELKAEVVGRDPKTDIAVLKIDASELPAATLGDSDQLEVGDTVFAIGNPFGVGMTVTQGIVSALGRGGLGVETYEDFIQTDAAINPGNSGGALVDSQGRVIGINTAILSRSGGFNGVGFAIPINFARSLAEQLVATGKIRRGFMGVTTQPLDSDLAAQFGVEQGALVTDVTSGSPADKAGFKSGDIITKVNGRPIADSRRLQLAIVRLAPGTEVQIEYVRDGETATATFTLGELSNRGELADGHFSPGSGEGVLNGVTVTDLSDQLRSRHRIPERIEGAFVAAVEPDSASARDGLREGDIILSLERRPVRNAEDAVKLSEELEGPKVLVLIWRAGLSRYLVITEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHN1</accession>
    <name>A0A139SHN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinuclear metal center protein, YbgI/SA1388 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713249.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08105"/>
    <dbReference type="EnsemblBacteria" id="KXU33990">
        <property type="protein sequence ID" value="KXU33990"/>
        <property type="gene ID" value="AXK12_08105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="254" mass="27715" checksum="28A45A745A7DB8EE" modified="2016-05-11" version="1">MPTTAELVAYCDQRTRRTAFVDAPAAHNGLQMDNSGKVTRIGAAVDAGLIPFQKAAAAGIDFLIVHHGMYWDMPRPIVGPVYERVATLLRADCALYSSHLPLDAHPEIGNNALIARQLGLGPERGFAPNPGGDIGLICRNTLTRDALEARLREHYRQVTAICYGAEAPREVALCSGSGNSALRELVGHDGRAIVDTLITGELREEHFNLAQEARLNLYLCGHYATEVHGVRALAAELANRFELPWEFIETENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHQ6</accession>
    <name>A0A139SHQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="3" type="ORF">AXK12_07985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713217.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07985"/>
    <dbReference type="EnsemblBacteria" id="KXU34112">
        <property type="protein sequence ID" value="KXU34112"/>
        <property type="gene ID" value="AXK12_07985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="311" mass="33614" checksum="2879FCE4FB66F070" modified="2016-05-11" version="1">MHPFTDKRSESVSALGEVRLLDKIRDWLGSAAPAEPYGMGDDCAILPRGKAARLITIDPVVYGGHFNDTMSPRATAQKLLKRNLSDLAAMGGLPTAAVLALTLEPRTSLRWLAGFYRALADCARHYAVPIVGGDITASTVPGHLSASLTLLGNPAHGSRTLTRRGAQAGDSIYVTGQLGNTLGTGHHYRFTPRLAEGAWLACQRAVRSMIDISDGLAKDLKSLQSPGLEAEILAEKLPLRRGANPRSAICDGEDYELIFTLAAKARRSDFERRWRAAFPKTSLTRLGQFVLAGTRSEAALNLANYHGYEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHY5</accession>
    <name>A0A139SHY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">AXK12_07930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07930"/>
    <dbReference type="EnsemblBacteria" id="KXU34192">
        <property type="protein sequence ID" value="KXU34192"/>
        <property type="gene ID" value="AXK12_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="180" mass="19625" checksum="0857471479E61F73" modified="2016-05-11" version="1">MSALIVEIANQHPRLHVKRAEVKRAFATLAKFAEQIVLPKTLPAGTKTEPPTAARQAKATASPVTLSVVFMTDDALAQLHADFLDDPTPTDVITFEGSPELGTAGEICVSADRAAAFAAEHQRDFSEELTLYLVHGWLHLAGYDDLKPTLKRQMRAAETRAMRCLSEAEAIPHFTIAAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI27</accession>
    <name>A0A139SI27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="11" type="ORF">AXK12_07875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713160.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07875"/>
    <dbReference type="EnsemblBacteria" id="KXU34183">
        <property type="protein sequence ID" value="KXU34183"/>
        <property type="gene ID" value="AXK12_07875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="210"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="31121" checksum="EAE78D2F71CDBA75" modified="2016-05-11" version="1">MNAPHQNLTSGQGPLANEEGLRPLQKKIGYAFRNLRLLEQALTHPSALNELPRRRAGNDRSPQKTVCERDRDQSNQRLEFLGDSVLQLILSEALYSLYPDDREGALSTKRFALVKGSTLSALAREIALYEHIRVGQSERTNTGTANTGNPTGSDNTSATASLRDSILEDAFEALVAAIYLDSDLPTAREIVLRLYGDIAQKLAAAAPDTNPKGRLQERVQPRYGNDALHYEVIATHGEAHAREFEVALRLRDQRIATGRGSSKQRAEEAAAREALAHWTDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI54</accession>
    <name>A0A139SI54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713193.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07815"/>
    <dbReference type="EnsemblBacteria" id="KXU34201">
        <property type="protein sequence ID" value="KXU34201"/>
        <property type="gene ID" value="AXK12_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="109" mass="11578" checksum="AB7E8A35F615582F" modified="2016-05-11" version="1">MSPLFDALNLLAQADAAPAPGGLLGGMLPIILLFGAMYFLMIAPQRKKQKAHDAMLKALVSGDEVVTTGGIYGQITNVKDDRFVVRIADNVKIEVGKSFISACVKKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB5</accession>
    <name>A0A139SIB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712977.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34289">
        <property type="protein sequence ID" value="KXU34289"/>
        <property type="gene ID" value="AXK12_07355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299208" evidence="1">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="21773" checksum="E108E1B928D79B78" modified="2016-05-11" version="1">MNHSRLLLPSYTLRRLAPFAHRLLLALLACTAAAFTAGVARAQPLPQGGYPISAPAPLDLRLLHAQANIGKKDYTLSPDAPPIVYPLGENFYRLELKMKRNSRKSWRSDETVKVHFYYDGVALTFFGDRNGNERPDRREKRQEHLIRHKHELVTEGNRTFNRSIDLHLELFGGEVSSASSLRSLKLHFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID5</accession>
    <name>A0A139SID5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713070.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07625"/>
    <dbReference type="EnsemblBacteria" id="KXU34335">
        <property type="protein sequence ID" value="KXU34335"/>
        <property type="gene ID" value="AXK12_07625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="242" mass="26529" checksum="723726BDA4B65520" modified="2016-05-11" version="1">MSQAIDELRRTIARLRGPGGCPWDQEQTHESLVRCLIDEVSELIETIDQADMPHMREELGDVLIQVVFHAQLAEEAGHFDLDDVAREVNAKLIRRHPHVFGEGAARTAVENTAQLFVQWDAIKAQEKAARGVSNASAQPRLFKAQPPRLPALMFAEGVWKQARKQSLTSALPVEVAQIAQRAEGLDEAQLGRALFELCAAAQQAGLNPEDALRRWTSQLVDHAEAVSSPAANAHAAKSENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE4</accession>
    <name>A0A139SIE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34319">
        <property type="protein sequence ID" value="KXU34319"/>
        <property type="gene ID" value="AXK12_07535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="70" mass="7658" checksum="CF8090A0619B31A9" modified="2016-05-11" version="1">MIEVPGGIAQLAPILPAGHIEHPPNRFSGDAHNHIVACGSLERSKGCFRILYMLQHFTTHEKIGTIAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH2</accession>
    <name>A0A139SIH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713091.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07695"/>
    <dbReference type="EnsemblBacteria" id="KXU34347">
        <property type="protein sequence ID" value="KXU34347"/>
        <property type="gene ID" value="AXK12_07695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="76"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="537" mass="60417" checksum="BFE01C2D9273AF06" modified="2016-05-11" version="1">MFARAFLSLFALTLLSACWPRESAVERGNRTQTLHRSLSADVAELDPHLVTGLPEIAVVTALFEGLIGEDPHDLSPVPGVAERWEVSDDGLRYTFHLRADARWSNGAPLTAQDFLASYARVLSPTLAADYASSLYLIQNAQAYHRGLCDFNDVGLSAPNPRTLVITLDHPVPHFLTLLTQPIWVPIYLPALEKTGQADTRGNPWTRPENFVGNGPFVLKQWKPDRRIVVERNPHYWDVASVRLSAIHFHPSSSVEAEERAFRAGQVHLTESLPLSKIERYAREHPDLLHVAPFLDTYFYRLNVTRPILNEVKVRRALSLAIDREAIVRLTAGRQRVATSFTPPGLAGYTAPQSTVRHDPVAARALLAEAGYEAGRGLPTLELLINNSGNHRIIAEAVQAMWQRELGLRVSIVNMEQKTLLAQRRALDYQLLRSDWAGDYLDPMTFLEIFSSTSGNNHTGWSSADYDALLYRAGRTLDANTRYSLLARAEEILLREAPIIPIYYYTTVRLISPSVRGWYPTLLDRHPYKYLWLDAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH9</accession>
    <name>A0A139SIH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ORF">AXK12_07605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07605"/>
    <dbReference type="EnsemblBacteria" id="KXU34331">
        <property type="protein sequence ID" value="KXU34331"/>
        <property type="gene ID" value="AXK12_07605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="43"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="405" mass="43086" checksum="F4B8CA64948A9519" modified="2016-05-11" version="1">MPSPNTTPSATASTPPDFDSLALPHVAALHAYTPGLQPTEPGWIKLNTNECPYPPSPAVAKAVAAELGADGAAGEVGAALRLYPEPTSAVLRAAIAAHHNTTLSAAGINGTSALRVANVCVGNGSDDILNLLVRCFCAEGAGQGSESGRAAGFTLPSYSLYPVLVGIANGQSIEIKFDRSMRLPLEQIASSGAAIFFLTSPNAPTGVGFSAAQIEALLAAYDGLLVVDEAYAPFAREDAVGLLARYPRLIVVRTFSKAYALAGIRVGYCLAHERVIALLDRVRDSYNVNRLSQAAALAALGDPQYYAHVIARVCATRDAALTRFAEQGWFCYPSQANFLFVEPRNGRGETGAAVAQAAYDFLRERRILVRHFPSPLTAPFLRITVGTDEQMLTLWHTLQEWLHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN7</accession>
    <name>A0A139SIN7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713080.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07655"/>
    <dbReference type="EnsemblBacteria" id="KXU34340">
        <property type="protein sequence ID" value="KXU34340"/>
        <property type="gene ID" value="AXK12_07655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="602"/>
            <end position="604"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="742" mass="79545" checksum="29D256A9BF755A9E" modified="2016-05-11" version="1">MSKPTIIYTKTDEAPALATYSLLPIVQAFAKHADIAVETRDISVGARILAQFPEKLSDAQRVGDALAELGALTLKPEANIIKLPNISASLPQLKEAIAELQAHGYAVPDYPENPTNDAERDAKARYDRVKGSAVNPVLREGNSDRRAPKAVKDYARAHPHSMGAWSQDSKTAVASMSGDDFYANEKSTTLAAATTARIEFAPAAGGAPKVLLEKLPLLAGEIIDATRLSKRALVAFYEAQITRAKAEGVLFSLHLKATMMKVSDPILFGHAVRVFFKDLLVKHAAALASLGVDLNNGLGDLLEKTKTLPAAERSAIEADITAALASGPAVAMVNSDHGITNLHVPSDVIVDASMPAMIRAGGKMWNAEGKPQDALAVIPDRCYAGIYQAVIDFCKTHGALDPRTMGSVPNVGLMAQAAEEYGSHNKTFEAPADGTIRIVDANSAAVLLEHRVEAGDVWRACQTKDAPVRDWVKLAVTRARLSNTPAVFWLDKARAHDAQIIAKVEAYLKDHDTSALDLRILPPAEACRFSLERIVKGEDTISVTGNVLRDYLTDLFPILEVGTSAKMLSIVPLMNGGGLFETGAGGSAPKHVEQFLAENYLRWDSLGEFFALAASLEHLALTFKHPRAKVFADALDTANGRFLENDKSPGRKLGTIDNRGSHFYLSLYWAQALAEQSADAELAATFRPIAEKLAASESQICAELLGVQGSPTDIGGYYQPDDARATAAMRPSATFNAILASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIQ4</accession>
    <name>A0A139SIQ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoF synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712891.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00420"/>
    <dbReference type="EnsemblBacteria" id="KXU34413">
        <property type="protein sequence ID" value="KXU34413"/>
        <property type="gene ID" value="AXK12_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="52191" checksum="51B654A196275700" modified="2016-05-11" version="1">MTSQPQFANSAEPFVREREAVEPSRLPEPLEDEIRAIYRRSPLYAERFPLHPEPLHWACYREIPALSKEEIVARGAEAFFQNYTEVERGLQEARYEYESTGGTTQRPMTVIMERGWWEAQTERAYRASPILREFVGRRYRKCVLAPVGCSSNLCPYEDHAFPNRYFDGTVYLNLSSDPFSFPESEWDRIVLELQATKPEVLEGEPVYLSLLARALARRGVRVPSVRVVILTYGKASRQHAARVSEVFPGARLVDLYGSTEAGYLFVGEAFCDNAQPVEENAFIELASFDWGAVGVPPTSGRAPGTGMPNERGCDRDVREIVVTTRGREAMPLLRYRTGDLVRKLPSGYRVLGRARDLYWRPHDSALISVYEVDAALPGDFACWHYQLVQTSAARWDFYYVADATYPAAKLEAALAELLGAGQGSSVRVNAFRRRVIAPSASGKFSPLRLLSKVSGFNQQVVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIT4</accession>
    <name>A0A139SIT4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712930.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34431">
        <property type="protein sequence ID" value="KXU34431"/>
        <property type="gene ID" value="AXK12_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="81"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="253"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="716" mass="79782" checksum="702A4EEA5CB6672B" modified="2016-05-11" version="1">MNKTKHPRPSTLLLTAISALTLGLVASIPLVAATSRDSALDLADADAPYQLDALSVEARDEVGAGWRPTRQVTATRISTPLEDVPRSVSVVTGEVMADLGETRIERTLDFAGGITRGNDFGGLNMASFNVRGFDTSAVYRNGFSASRGNNSPPDAATIERVEVLKGPASGLFGRGDPGGIVNLVTKRPQRETFTRISASAGSWDRYRATLDTNTPLNASGTLLARFNMALEDTRSFRDHIETQRYLFAPSLSWQVTEKTLLTLEAQYIRNDNLFDRGIPAVDGDFGRVRSKNFYGEPANGKVKNKNHSLQAALEHQLAQHWKLRVAGQFYHGHYHGHTMHMDAPLPSTPTIVRRTYEWRNAQWQDYHQHAEVHGKFTLFGAEHHVLVGAEYEHYRNGQFYPRTGYTNTFGVDIFEPAKDYGKTPPPYTLVSDNLSREESYALNLQDQIYFTPELIGSLGLRHDSVKTSSHQRLSSIRSSYERDATVPRAGVLYKFTPQISGFANASRSFKPNGVDSNGEIHKPEEGTGYELGTKFNLFQGRLGGTLSLFNIVRENVKVPHPDPTVVDQITVGEQRSRGLDLQITGKLTDELRFIAAYAYIDAEVTKDTRPGYQGQRLAGVPEHNASLFAIYALPRGLEIGTAYTTFGARKTSITGTLKVPSYQTVDLFARWRANDRLHLTLNLYNLLDEQYFNNGYNWWSVPGDPRSFKLTATYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ26</accession>
    <name>A0A139SJ26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712804.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34521">
        <property type="protein sequence ID" value="KXU34521"/>
        <property type="gene ID" value="AXK12_07145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="224" mass="23858" checksum="2A294D3840ADCBF7" modified="2016-05-11" version="1">MSLRSLLIIAPGALLLIAALAFVFVNKDDGHGHDHHGHSHGAHSDHDHDGHSHGSATASTSAPHDHAGHSHSHGGPAPQVSIEHSDEWRAHYSSASLPLVFKSLLAARDALRYGLDQDAELPALTRYAETIHLTAHALLDQVVLPQPAEQQRLNASLAQTAALADALLEPLHHSERAAARTSFSRLNSAIGVVSIRLPELLQSQAEQLSEAPIFAPAPAHTHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJN1</accession>
    <name>A0A139SJN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ORF">AXK12_06780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712670.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06780"/>
    <dbReference type="EnsemblBacteria" id="KXU34788">
        <property type="protein sequence ID" value="KXU34788"/>
        <property type="gene ID" value="AXK12_06780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="127"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="31381" checksum="984787C793968881" modified="2016-05-11" version="1">MPLKASRPTTASQRFTTLNHQPHLAKKRPERALTESKHKSGGRNVYGRITSRRRGGGHKQLYRIIDFKRAILDIPARVQAIEYDPNRSANIALVAYANGEKRYIIAPEKLAVGATIVTSNTAGHNDFKVGNNYPLSLIPPATRIHAVELVPGRGAQLARSAGASIELVAVENGFAQLKMPSGEIRLVNPKCRATIGEVGNSDHSNQSLGKAGRKRWLGRRPRVRGIVMNPIDHPNGGGNGLSKSGGGRQHLVSPWGQLAKGYPTRRRSKPSNSQIIVHANGRKPRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ1</accession>
    <name>A0A139SJQ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">AXK12_06785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712672.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06785"/>
    <dbReference type="EnsemblBacteria" id="KXU34789">
        <property type="protein sequence ID" value="KXU34789"/>
        <property type="gene ID" value="AXK12_06785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="91" mass="10067" checksum="12EECE2C983B5E2A" modified="2016-05-11" version="1">MARSIKKGFFVDYHLLEKIEKAAAAGSHKPIQTWSRRSTITPDFVGLTFSVHNGKAFVPVHVTENMVGHKLGEFSPTRTFKSHGATTKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJT9</accession>
    <name>A0A139SJT9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">AXK12_06805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712680.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06805"/>
    <dbReference type="EnsemblBacteria" id="KXU34793">
        <property type="protein sequence ID" value="KXU34793"/>
        <property type="gene ID" value="AXK12_06805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="68" mass="7920" checksum="2754F418D2DE5C89" modified="2016-05-11" version="1">MTSKEIRELSPTEITAKLRELRDQLLQLRLRKQTGQLEKTHELRALRKTIARLETILNEKSRPQVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV2</accession>
    <name>A0A139SJV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">AXK12_06875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06875"/>
    <dbReference type="EnsemblBacteria" id="KXU34816">
        <property type="protein sequence ID" value="KXU34816"/>
        <property type="gene ID" value="AXK12_06875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="133" mass="14170" checksum="83D91F02D97B5C44" modified="2016-05-11" version="1">MLKEELGTIKIRKAKGSKNISSGVANVLASFNNTIVSITDPKGQVISWSSAGKCNFRGSRKSTAYAAQIVAQDAARTAMSHGLKEIVIRLSGPGMGRDSAVRGLQAIGLEITSIIDVTPVPHNGCRPRKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV8</accession>
    <name>A0A139SJV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34813">
        <property type="protein sequence ID" value="KXU34813"/>
        <property type="gene ID" value="AXK12_06925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="440" mass="46625" checksum="198106701EF6C324" modified="2016-05-11" version="1">MIFLTIFIDLLGFTIIFPLFPAILDHYFALEGNRGLLGALLGGIDRLAELSGSAGNYRAVLFGGVLGSVYALLQFTFSPVWGSLSDRIGRRPVLLMTVAGTAASYVLWFFSGSFLLFIIARLLGGAFAGNLSVATAAAADVTSRENRAKGMGIVGVAFGLGFLFGPAIGSIAAFYDLSASTVENCATATGGTVRAAGLLSFSVNPFSLPALLALGFSLINLVWIALKFRETLNPAKCEEAPARVRFPIGALRELERGPARRTNWLHFVFSLAFSGMEFSLPFLATERFGYAPTDMFKVFVFLGLVLILTQGLVVRRAVPRFGEKAVLICGLLSVSIGITLMGSAASIPAFYVGLAVTGLGSGLINPSVSALVSLYSPASQQGLTLGVYRSLGSLARGLGPLVACFCYWWQGATTTYLLVALVTLIPWLMAIALPRPVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJW8</accession>
    <name>A0A139SJW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06310"/>
    <dbReference type="EnsemblBacteria" id="KXU34851">
        <property type="protein sequence ID" value="KXU34851"/>
        <property type="gene ID" value="AXK12_06310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="194"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="391" mass="44272" checksum="B07D23344137D2EA" modified="2016-05-11" version="1">MTTVSKIERPRQLERIEEAMALSPVTALLGPRQCGKTWLVRELASGPGNYFDLYDYASRSLLAEHHFSALDRLTGTVVIDEAQLLPELFMKLRILADRPEQPAHFVITGSASPYIVRGVSESLAGRVRLLPVSGFNCSEVGWENWERLWLRGSYPRSYLNAKSEASLDWRLDYVVQFVSKDLRGIADIKLSDEQLQRLLQMVANYHGQYWNHSQAAELVGVSYKTVQRILELFKGAFITRELPRFFTNSGKRLRKAPKIYLRDSGLLHAMLMVRDYQQLLAHPILGASWEGFCIEQIIALSEARAEDCFTWGLQSGAEIDLVLVRPSGTYGFEFKASGTPKRSRSMLRALADLPLKKLFVVYPGQRNYSIDEKIEAIGLPNLMDAIAQMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK08</accession>
    <name>A0A139SK08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06345"/>
    <dbReference type="EnsemblBacteria" id="KXU34857">
        <property type="protein sequence ID" value="KXU34857"/>
        <property type="gene ID" value="AXK12_06345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="362"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="905" mass="100865" checksum="3208D614CF6AE9F3" modified="2016-05-11" version="1">MPGEEDQSEAGLTDVLTLAAFEVSSDRIERTAYEGNMDLLRSEYDVQPYSIIGREVITRSGATTVEDLLRQQLTMNTAFSSSAQSATGYGGSASSFSLRGLSAAETLVLINGRRVAGVGRSSSTEAGDQPDLNGIPLAAIERIEVLPASASAIYGSSAVGGVINVVLRREYSGHELNTRFEMTDDWHAPIETFNWTSSFQFEGGRTQLLISAQYQDTRALYGHQRDFQRKGRAQILENDPDAFYVPAGTRASPPWGALVNIRSRDGSPLFGPGSSHFTHIPKGYRGWQIDGLQPLIDNQGTYNLDLARGMASGFTADAEIMAASRSKSLSLNGSREMTEKLKVFFDGGYSHSEQNPYDSWYGAWTVRLFADSPNNPFGQDVQVTYPVRNVDRRSSSEVNTTIRGERVAVGFEYELPRRWRVVGNYSWSHSVNHHQYLTRYGSPTREDAIHDGVLDVLRDTSSFPTLIDEYAGMLHRITNAWSSDSTLRAAGGLGDWWYAGEIILANGIERRELRQFGIGGNSDDLHPPPVHRRQQVDSFYTEATVPLVASHQRRRWLHSAELQLAARHERFNVETAGSKYDTTVPTFGIRYLPVRELIFRTSYGRGFRAPTYAQLTEPTLSTSTSTVNDPKRGGEAVDIFTLRGGNTAITPETSRNLNIGLVWSPERIPGLRFSADWYRIEKRNNITTPGTQALLDEEDEYPGRVIRGPVDPSDPYYPVGPVIQINRAVMNMLKMETSGIDLGARYLWRGGSFGDVDIAANATLSDYYRTQTSITSGVLERRGIPSQSGPLNQRINGSLVWTRGPWSCGWATQYYSRYRITPTSTTSIRRQGGPLVASQIYHDVFVRYRVSTRGRHRAFEGLELTLGAKNVLDKAPPTDMSRGYYYSTFGDPRMRRLYANVKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK12</accession>
    <name>A0A139SK12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712615.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06675"/>
    <dbReference type="EnsemblBacteria" id="KXU34912">
        <property type="protein sequence ID" value="KXU34912"/>
        <property type="gene ID" value="AXK12_06675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="358"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="677" mass="74230" checksum="D5C6D9D71995A921" modified="2016-05-11" version="1">MLPTIPTRLEARTLRCEDLENRRTEALLQLYAWMYLSRATDNRILDLFRQGLIKGTVTGGQGNEALIVPLALLADKARDVVSFTHRGLGGHLIWSGHLCEHLNQYFANAQSPTKAREGNVHHGDPANRSLPMISHLGTMISNVLGATDAQRRNGEPAVGFAFFGDGSSSTGDVHESLNLASLLGLPIVFVIENNRYAYSTPTEEQYPQNVQLWQRAAGYGIEGISADATDAEAFAQTLGAAIDRVRANSQPILIEAHTLRLRGHAAYDTCDYLKPGENDAFHAADPLPRFREKLVREGQDSALSEIEAELDHYLEACVKHSLAIPGPSAGDMLGELFAAPTARAPITWAATPAEPQPLNFAQAITAAHRKILSERPESLILGQDIGRYGGAFKVTDGLLDEFGRSRVFNTPLAESACTGYAIGLALSGYRPIEEFQFADFATEAVTQITQNAATYFFRAGAACPLVLRFPCGSVQLGSFHSQELEATFLSFPGLKALYPSTPQDAFDALLAAYEDNNPVLLFENKALYRSPKQPVAWNPDYKKIWEPKQLAQGDAATVISYGEAVRRTEAVCAYLADEYEITLDLFDLRALSPLKLDQIETSLARTGRLAIIHEGRRTHGFGAELAARLTESHFAHMKAPPLRIGSMDVPVPFSSELENVYRPQQDSIIEQLLNWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK27</accession>
    <name>A0A139SK27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06705"/>
    <dbReference type="EnsemblBacteria" id="KXU34932">
        <property type="protein sequence ID" value="KXU34932"/>
        <property type="gene ID" value="AXK12_06705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="178"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="415" mass="45047" checksum="964BE86991CF5A68" modified="2016-05-11" version="1">MAHLTTINPRSPHVTSPRSSPASEKKSREAATLIYADTATNADQLYFSRVDVHDPFIAFGIGGKRYTVQSALEFGRVKKARSFDEVLALEEWSERAKKAFSARAKNTTSARTRTPVAIGPAEIIATIAKAKRIRRFRVASDFPAALFVKLGALGVEVEIADGPLFPEREIKSPREAAAIREGNRLSSVGFSAVEDILRRTKIRGRELIFEGRPLSSERLHFAIQAAILAEGGRADDTIAAGGDQACDPHERGHGPLRPHELIIVDIFPRVVKTGYFGDMTRTYLKGRASEAQRRLVATVHAAQRAGIAAVREGVDGAHVHGEVLKTFAAAGYETRRGPHGSVGFFHGTGHGVGLAIHEAPRVNSQPYTLKKGSVITVEPGLYYPGLGGCRIEDVVQVGARGAKPLSSHPYDWEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK36</accession>
    <name>A0A139SK36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="8" type="ORF">AXK12_06740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068630664.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06740"/>
    <dbReference type="EnsemblBacteria" id="KXU34921">
        <property type="protein sequence ID" value="KXU34921"/>
        <property type="gene ID" value="AXK12_06740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="14004" checksum="AE19DD2E759BA5DF" modified="2016-05-11" version="1">MPTINQLVRKGRRKVVAKSKSPALDSNPFRRGVCVQVMTRTPKKPNSAIRKVAKVRLTNGIEVISYIPDEGHSLQEHSIVLVRGGRVKDLPGVRYHIVRGALDATGVEKRRRSRSKYGVKRPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE8</accession>
    <name>A0A139SKE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712366.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00190"/>
    <dbReference type="EnsemblBacteria" id="KXU35025">
        <property type="protein sequence ID" value="KXU35025"/>
        <property type="gene ID" value="AXK12_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="269" mass="28775" checksum="E743AD0BC63D1ADD" modified="2016-05-11" version="1">MPLLFWLKKAVTYFLLPLQLSLTLMLLGGILVWLTRRKILGRLCLTSGLLLLLGFSLKPVGRALLGPLETRYAPIPELAVGEALPPELAECRAIVVFAGGAANTARLPATLRLSEAGLARLVEGVRLARLLPEATLILTGPARDKGAPESETAAATLARAAESLGIEPQRMRLLTTALDTEGEVAALAALYGPNTPLALISSAAHMPRIMAYAEKAGLHALPCPANFAIRPDPKFRWNEYSADISGLTHSTGGIYERLGLLWAYLRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKH0</accession>
    <name>A0A139SKH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-beta hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712386.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00250"/>
    <dbReference type="EnsemblBacteria" id="KXU35035">
        <property type="protein sequence ID" value="KXU35035"/>
        <property type="gene ID" value="AXK12_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="342" mass="37536" checksum="1B35F305A26E9699" modified="2016-05-11" version="1">MSSHTSSGSSTLVTGGTGFLGKRLVLRLLAEERRVTVLSRRADAELASRGVRFVCASLDDVQAVRAACAGQGTVFHTAAKVGVWGRYTEFYKTNVLGTRAVIEGCREHGVARLVYTSTPSVVYNGRDIAGGDESLPLTTRCPSPYPLTKAIAEREVLAANSENLRTAALRPHLIWGAGDPHLVPRLLAAARCGRLRIVGDGKNRVDMVHVENAVDAHLLAEAALHRDFARNTAAGRPYFITDGEPVRLWDWVDGLLRALGEPSVTRRISLRGALRLGGFCEGLWRALPFLLRGEPPMTRFIAAELAKDHWFDIGAARRELGYVPRVSMEQGFRELIDWLHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW7</accession>
    <name>A0A139SKW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712126.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05650"/>
    <dbReference type="EnsemblBacteria" id="KXU35189">
        <property type="protein sequence ID" value="KXU35189"/>
        <property type="gene ID" value="AXK12_05650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="434" mass="48167" checksum="6C100DC68FD9D07C" modified="2016-05-11" version="1">MLHLNVFLFGCGHHRAAWCHPDSAAERLGDIAWYESLARTAERGKLDAVFFADGHSAGAFGMGSDGPLWYLEPLTMLSAMARATERIGLVSTVSSTFFTPFHAARMLASLDHISGGRMGWNVVTSMFDAEARNHGFEAMPDHAWRYARAEEFVEAVLRLWDSWDDNALIVDRRAGDYVRPGAVRRIDHRGEHFRVDGPLTVPRPPQGHPVMFQAGASEQGRDLAARYAEAIYAVAYDLPSAQAYYRDVKRRVRAAGRRDPVPIMPGLVTYVGSTEAEARAKQAELDALLPTESSLRQLQTFIDQDCMDWDLDAPVPPLPPLDAFKGPKGRYATILRIIDTERPTLRQLLGRLAAGGGHCTMVGTPEQIADRMEQWLREGGADGFNLMPPSLPHSLDDFIDQVVPVLQARGLFRRDYEAGTLRGHLGLARPVRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX0</accession>
    <name>A0A139SKX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05720"/>
    <dbReference type="EnsemblBacteria" id="KXU35202">
        <property type="protein sequence ID" value="KXU35202"/>
        <property type="gene ID" value="AXK12_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="14301" checksum="9AC70DDA88D2FD07" modified="2016-05-11" version="1">MTIRFEELARRASRVVARLQTRLPPEIAPLARGVPVHYESAPSESILAEGFEPDILGLFSGNPYGSDFRESDPAPPQIFLYLENLWDFAEGDLRVFREELRVTYLHELGHYLGWDEEELAVRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL02</accession>
    <name>A0A139SL02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712229.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05905"/>
    <dbReference type="EnsemblBacteria" id="KXU35233">
        <property type="protein sequence ID" value="KXU35233"/>
        <property type="gene ID" value="AXK12_05905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="369" mass="42789" checksum="07A7A8C0E035B1D9" modified="2016-05-11" version="1">MTDAAHHADGPAQSAETPTPRKPSFAICDGLRGYLANYKRERLLPISYERLCDFHETIPLVDRDGQPTLWDTVIYRHDEMGPLYEELKATYALLKVDGDSRVVRHLYIDRVDYCSFGNSMPFRVRIVNSFNDNQDYFYVKRADASRVYGLELEHLLSPSRLNFITHGGTLIEEHIAGIPGDVFINTWLRSPELLPVRVAKELVKFNERCFLRLLGDMRAYNFVFVITPDFEAAQVRIRAMDFDQQSYNGRKKFYLPQFFKENAPLVRYCTKHLHVETALQYQREEHTLIVGRAELARVRLAELLHEMSADAIAPREKIHHLRAELAEHFQRSEYLHCESMGALVQQNLLTLRETIARHSPPPIDLESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL18</accession>
    <name>A0A139SL18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712300.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06100"/>
    <dbReference type="EnsemblBacteria" id="KXU35268">
        <property type="protein sequence ID" value="KXU35268"/>
        <property type="gene ID" value="AXK12_06100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024765">
        <property type="entry name" value="TOBE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12857">
        <property type="entry name" value="TOBE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="40008" checksum="3818E14AC1569844" modified="2016-05-11" version="1">MSIEVSHLRKTFGAYTALDDVSLSVKPGQLTALLGPSGSGKTTLLRIIAGLEFADAGSGAVRLDGEDVSALGPGQRGIGFVFQHYALFRHLTVFENIAFGLTVRRKRERPSRAEIAERVNRLLGLVQLDGLGQRLPTQLSGGQRQRVALARALAIEPKVLLLDEPFGALDAKVRKELRRWLRQFHEEVNLTTLFVTHDQEEALEIADEVVVMNNARIEQVGPPQAVYDHPASPFVIEFLGNVNQLTAGTAKPSARAAADAAKQAVEGKVTSDGDLLYVRPHDVDIRREPKSTHAIPVKVLHVFAAGNTGRVALRRLDTGEAFDAELSRVRLAELGLHQGDSAWVVFRHVRLFPKGQFYETDVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL28</accession>
    <name>A0A139SL28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06070"/>
    <dbReference type="EnsemblBacteria" id="KXU35262">
        <property type="protein sequence ID" value="KXU35262"/>
        <property type="gene ID" value="AXK12_06070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="469" mass="52185" checksum="0B652E06F5CA99EC" modified="2016-05-11" version="1">MSAFIMLGALRSAGCFCDSFLTLSIIRLRVWIGFLCTVLLLLAAQGQRAHAQVPRSHNKPTGAPIMLGIDVLEEQGFKAIRQKRIGLLTHPAGVNRRGESTIDVLLRAQRTSGAKLVALFGPEHGIYGNFKAAVDVGDSTDTRTGLPIYSLHGTHRKPTPKMLAGLDAMVIDLQDIGTRSYTFVSCMLYTMAACFENDVEVIVLDRPNPLGGLKVDGPPLDTEWKSYVGAFRVPYVHGLTIGELAHMAKSAPGIMRVPGANGINVSEAHRQKGRLTVIPMRGWRRTMRWPETGLKWVPTSQYIQDFASVVGYPMLGLGTEIGKFTHGLPGPRYPFRTLAHPDIKLEVLQKELAALRLAGLRFTLIDVKNRQGKPAKALYVEVTDWDAWRPTELNFHLMRLAAKYEAKNPFVGLNAADKRRFLIHPGSAALLAELQRHGARTNIEALLRDWRARALVYQRHSRKYWLYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL34</accession>
    <name>A0A139SL34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyamine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05770"/>
    <dbReference type="EnsemblBacteria" id="KXU35278">
        <property type="protein sequence ID" value="KXU35278"/>
        <property type="gene ID" value="AXK12_05770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="267" mass="28771" checksum="C8E5213CE454CCFC" modified="2016-05-11" version="1">MLPTIAEAPPAVEVVGLSCGYGAEAILEDLHFAVRTGEIFFIIGASGCGKSTLMRSLIGLNPPLAGQLRFFGEVMSATASEAPRLAETNPCQRHHLGTSFGVLYQSSALWSSLTLRENVALPLREYGQLSPREIDEIATLKLTQVGLCGFEDYYPSEISGGMKKRAGLARALALDPPLVFLDEPSAGLDPISARKLDELMLQIRDLFGTTLVVISHELGSIFRVADRLILLDKAACGIIAEGAPRELARMSTDPRVREFLGHGTAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL46</accession>
    <name>A0A139SL46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_06130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712312.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06130"/>
    <dbReference type="EnsemblBacteria" id="KXU35273">
        <property type="protein sequence ID" value="KXU35273"/>
        <property type="gene ID" value="AXK12_06130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="266" mass="30193" checksum="7AFB96A04BB9F45C" modified="2016-05-11" version="1">MIDWSHWHNEPYLIGGLVFLGWLYAILTGPLRAAVAARGAAEAYPRAHAFKFYAALLLFYLAVGSPLDQIGERFLFSAHMVQHQLLMYPVPILFLLGLPAWLVDPALARIPRPLVRFVFNPIVCGLTYTLIISVWHAPLLYNWALRDKVVHVIEHLMFFASALLYWWPQLSPSRVAARAIPYPAQLLYQLGIIIGMMPVYAYITFSKEILYPTYEYAPRIIANFDPAQDQLLAGTSMQLMSVFVAVTAGGVAFYKWYQAQEGRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL54</accession>
    <name>A0A139SL54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LL-diaminopimelate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712180.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05795"/>
    <dbReference type="EnsemblBacteria" id="KXU35214">
        <property type="protein sequence ID" value="KXU35214"/>
        <property type="gene ID" value="AXK12_05795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="35"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="408" mass="44572" checksum="7CCB07D5CD4CCBA1" modified="2016-05-11" version="1">MIRINENFTKLKASYLFSDIAKRVAAYASAHPDKPIIRLGIGDVTEPLPPACVSALHAATDEMAARDTFRGYGPEQGYPFLREAIAAHDYAARGCAIEADEIFVSDGAKCDSGNIQEIFGADIRLAIPDPVYPVYVDTNVMAGRTGANIDDRYEGITYLDCTPANRYVPAIPDTPTDLIYLCFPNNPTGAVATRDQLAAWVAYAREHRAIILYDSAYEAFIRDPQIPHSIYEIEGAREVAIEFRSFSKIAGFTGTRCAYTVVPKSLHAYDSAGAPHSVHALWNRRHTTKFNGVAYPIQRAAAAVYSAEGQQQTRALTEFYLGNAKLIRSRLESLGLPCIGGDNAPYIWINTGTDSWAFFDKLLNEAQVVCTPGAGFGKCGEGHVRISAFNSRENVETALDRIAKALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL56</accession>
    <name>A0A139SL56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_06085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712294.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06085"/>
    <dbReference type="EnsemblBacteria" id="KXU35265">
        <property type="protein sequence ID" value="KXU35265"/>
        <property type="gene ID" value="AXK12_06085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000957">
        <property type="entry name" value="Sulphate/thiosulphate-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00401">
        <property type="entry name" value="PROK_SULFATE_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299332" evidence="7">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="333" mass="36334" checksum="F51789DC0E018BE2" modified="2016-05-11" version="1">MNFRIPLFAALVALAPGLASAKNVRLLNVSYDPTREFYVEFNKAFATHWKAKTGDTVTVQQSHGGSSKQARSVIDGLGADVVTLALSADIDAIAERTGRIPADWQTRLPAASTPYTSTIVFLVRKGNPLGIKDWDDLVKPGVSVITANPKTSGAARWSYLAAWAYAKHRYGSDDAARDFVTTLYKRVPVLDSGARGSTITFTQRGIGDVFLSWENEAFLALKERGEGEFEIVVPSLSVLAQPPVALVEANAKRKGNLEVAQAYLDYLYSPDGQRLAARHYYRPQHPEHADAADAARFPELERVTVDEEFGGWANAQATHFADGGVFDQIYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL63</accession>
    <name>A0A139SL63_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Azurin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35285">
        <property type="protein sequence ID" value="KXU35285"/>
        <property type="gene ID" value="AXK12_06105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="113" mass="11973" checksum="DAB465B752371356" modified="2016-05-11" version="1">MKYNLSALSLKAGEEAKITLRNIGTMPKAAMGHNLVILKPGTDVEAFALAAAAEPANDYIPAALVNQIVTHTKMLGPKESATLTVTLDAGEYPFLCTFPAHFQVGMKGTITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL67</accession>
    <name>A0A139SL67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05765"/>
    <dbReference type="EnsemblBacteria" id="KXU35277">
        <property type="protein sequence ID" value="KXU35277"/>
        <property type="gene ID" value="AXK12_05765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="407" mass="43047" checksum="C473956093A95908" modified="2016-05-11" version="1">MTVAPSDSSQARADFSLNEAAVGGRVATVTLSGRWSVMARRPSAEDLLAEMARSSPQVTTLKVVGAFDTERVAGPGLRPRPAAEIKRAVACWDSSLLLFLFDLKCGCERAGIGCDLSQVPPRLCELVAQFAAAHETSVPRDRSEPFLATVGRETLDALRKGREFFAFVGECAISLGGLVRRPRRFRWADCLEQMQHCGAMALPIVSLVSILVGMTLGYTAALILRQYGGDIYVADLVGISMLREMGALMTAIVLAGRSGAAFAAQLGNMKASEEIDALRTLGLSPIDFLVMPRLLALFVMMPLLALYANCLGILGGMLVASAVLDISPSAYWVEMLTIVDLSDLASGLIKAATFGVIVGLAGCLRGLQAERSAVGVGMAATSAVVTAILFIIIADALYAVVFDILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL99</accession>
    <name>A0A139SL99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05600"/>
    <dbReference type="EnsemblBacteria" id="KXU35322">
        <property type="protein sequence ID" value="KXU35322"/>
        <property type="gene ID" value="AXK12_05600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="411" mass="45961" checksum="CD1670E70D35EC8F" modified="2016-05-11" version="1">MGGFAAMHHLTVAELEAEGLVKLTCTCDPRADSAFAAQQQAWRFAERGVRVFSHYQQMIDQCRDALDYVVVSTPINLHAEMHRAAAEAGIPCYLEKPATLDYIELEEMIARDARLPRASLVGFNFIIGPTRRALKQRLLDGEFGAILEATLLGRTPRPADYFYRTDWAGRLMMGERIVLDSCLGNANAHLVHNMLFWLGQGGLSTWADIATVRAELYRAHAIEGADTFFVQASSAEGQILRCAVTHACAGETRHCETLRCEKAELRYIVGSHAEIHWLDGRPNERIDTRGFDPLRENHLAYRRYLTGEESRPATSLADSRPFVHLNDLAHISSGEITPLPGELISHTRNEREQKDYISMSGRMQEAMNRFLDTGTFPGKQWGRRSPAVLVTPAALPKLHDTVRAMHAALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLC5</accession>
    <name>A0A139SLC5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712043.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05420"/>
    <dbReference type="EnsemblBacteria" id="KXU35290">
        <property type="protein sequence ID" value="KXU35290"/>
        <property type="gene ID" value="AXK12_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="445" mass="47101" checksum="C1A2931108E665C8" modified="2016-05-11" version="1">MSTPEPSPTPKAIKPRRFELITLGDELLLGLTANSHLTFIGGQLGRRGVQLARNVTITDEAGAIERQFRESWAGADVVITSGGLGPTCDDRTREVIAEVLGQSLVFEPIIEAAIMERFNRFGLKTLPPNNLKQAYRLEGGDFLPNAHGTAPGLWFEEAGKVLCMLPGPPNELQPMFTEQVLPRLAERGFLLSGEAYVQLRTAGIGESELEARLQPVFDAHGGAGEDGPLSVAFCAHAGQVDCRLSSPSGLLTSEQLQAIAAQCEGLLGEDFMCYGEASLAKVCVDLLRAGDKTLAVAEAGTGGLLTSEFGEICGVAKCFLGALVCNSNEAKVTLLDCPECLISQHGAVSAECAVALATGVAERLGADYALSITAFSGAPCANERGNEVGTIFVGLHAPDGVWARKLSYPGPRRTIKTRAVNAALDWLRRELVRANARSAEGACLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLD2</accession>
    <name>A0A139SLD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35368">
        <property type="protein sequence ID" value="KXU35368"/>
        <property type="gene ID" value="AXK12_05180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="126" mass="14019" checksum="5C8295A095FA3AC5" modified="2016-05-11" version="1">MSKQAQPLEEKLETVRGQVEALGEQLGAIFQKPQPAPEPVGLSPAIFTQDGWSEWAGQAGHPEWLQVLATYPHWLVLGCAGVLGIGLLWLGFRMLKWTLTLLIPLVIVAVVVWCIWFFWLSERAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLD5</accession>
    <name>A0A139SLD5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="10" type="ORF">AXK12_05480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712065.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05480"/>
    <dbReference type="EnsemblBacteria" id="KXU35300">
        <property type="protein sequence ID" value="KXU35300"/>
        <property type="gene ID" value="AXK12_05480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="247"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1409" mass="155626" checksum="4DA4007CB1DD221C" modified="2016-05-11" version="1">MSIQPSETLGAHARDEARSALGEAESPFDCVSITVASPEVIRKWSRGEVKNPETINYRTFKPEPGGLFCQKIFGPVRDYECACGKYKRIKFKDVVCDRCGTEVTVARVRRERMGHIELAVPVTHIWFLKSMPSRLGLMLDMTARALERVIYYENYMVIDPGKTPLEPHQLLTDTEYRQALDEYGDDSFVAKMGAEAVRDALSRVDMEAVVAELHEQMRATRSKQIKKKLSKRLKVIQGFIQSHSRPEWMVLEVLPVIPPDLRPVVPLEGGRFATSDLNDLYRRVINRNNRLRNLMQLKTPDVIIHNEKRMLQEAVDALFDNGRHGRPVTGAGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVIGPELKLNQCGLPKKMALVLFEPFIIRRLKELGFVHTVRGARKMIEKKSPEVWDILEEVTKGHPVLLNRAPTLHRLSIQAFEPVLIEGEAIRVHPLVCTAYNADFDGDQMAVHVPLSLEAILECKLLMMATSNIFSPSSGKPILTPSQDIVLGAYYLTIEPRKKPAKDERVPLLSGLDEVQFAKDDGALKMHDWVDVPNPDYGRSTTYGNPLKKVIRTTVGRIIFNQVWPRDLGFANFPVPKGKLGDLILETTKLEGIDPQEVVDTLDRLKDLGFQTAFRAGISIGVDDMIIPESKKDIVAETRKKIAEVEGQFNKGIITEGERKNKVIDLWTGTTDRIAKEVFAKLEQNDGREEVNPVYIMMDSGARGNKQQVRQLCGTRGLMAKPSGEIIERPILSSFREGLTVLEYFISTHGARKGLADTALKTADAGYLTRKLCDVAMDVVIVEDDSGNRDGVWKKAIFEGDDEIVGLRERIVGRCASDDIYNPLNPSELLVASGDLITEEMAVKIDEVGIERVKVMSPLTSNSPRGIDAKSYGINPATNKLAKIGDSVGIIAAQSIGEPGTQLTMRTFHIGGVASGGFKTPEIRVREGGTVKYRGLRLVQTAEGASIVLNKTGSIEIQDDEERELESYNIVAGSFLHVADGARIEKGAVLAQWDPYNIPVLSEKGGKLVFKDMIPGVTVKRELDESSGRIATVVIEHKEDLNPQVEVRDARNQPLAAYSIPVGAQIAVNEGDTIAPGALLAKTPRQASKTKDITGGLPRVAELFEARCPKEAAAMSRIDGVVSFEGTVRAKRKVVVRNEETGQEEEHLIAAGKHIIVQPGDVVHKGQHLTEGAADPHEILEILGPAALYDFLISQVQEVYRLQGVTINDKHIEIIIRQMLRKVRITDPGDSEFFWGEQVDRSNFLIENRRIESAGGKPAEAEPILLGITKASLETESFISAASFQETTRVLTDASTLGKVDDLKGFKENVIMGRLIPAGTGLPKYKQLKITLPFGEELVEDLGEPQPDSEMEAEVAAAVAQAQAAMGLVGNLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE0</accession>
    <name>A0A139SLE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biopolymer transporter Tol</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711954.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05205"/>
    <dbReference type="EnsemblBacteria" id="KXU35371">
        <property type="protein sequence ID" value="KXU35371"/>
        <property type="gene ID" value="AXK12_05205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="403" mass="43789" checksum="8669570C5CECC1B5" modified="2016-05-11" version="1">MILSLSRFLFSLVTLLGVLPLVVQAQRNVGDVVIASDVQVVPVRVSSTTSELGALAQQAFGVHGRYRVVGSGHRYDIRFAQAGAAQVRVEIANASGGLVHSQTLSGDTLRHALLRAADVAVERTNEVGLRGFFASKLTFVAERTGRKEVYISDLFFGELRQLTRDNSQSLTPRWSPDGSRIIYTSYFRSGFPDIFQIDLRSTQRTSFVSFKGTNSGARFSPDGRQVAMVLSGEGNAEIYVGNAQGRQIRRLTRTDAVEASPCFSPDGSRIIYTSDSAGGPQLYVMSVAGGAARRVPTNISRYCSEPDWSRADANKIAFTMRIGSGFQIATYDFSKSGEPARQVSNAPFDAIEPCWLADGRHLIYTARDRQTSRLCILDTETGRSTTISPAALGAALQANALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF9</accession>
    <name>A0A139SLF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_05320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711988.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05320"/>
    <dbReference type="EnsemblBacteria" id="KXU35391">
        <property type="protein sequence ID" value="KXU35391"/>
        <property type="gene ID" value="AXK12_05320"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="27563" checksum="BBF8E5CEE1930375" modified="2016-05-11" version="1">MDLSVYRNFLAELAYASGKFLKPYFARGLANDLSALAVEHKADQSPVTEADRDAEALLRQKIKTQFPAHGIIGEEHGTERDGADFVWVLDPIDGTKSFISGVPLWGTLIALLHNGAPILGAIHQPTLGQLLIGDGQSAELNGRRVRTRTTTTLAEATLLTSDTVNLDARMGAARASALLGRARIARTWGDCYGYLLVATGQADAMLDPIMNPWDIAALVPIIRGAGGVISDWTGGAAHRADTTVAAATAELHATLLTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG0</accession>
    <name>A0A139SLG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein P47K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711986.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05305"/>
    <dbReference type="EnsemblBacteria" id="KXU35389">
        <property type="protein sequence ID" value="KXU35389"/>
        <property type="gene ID" value="AXK12_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="421"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="516" mass="56341" checksum="C8971FC4FCDB35C6" modified="2016-05-11" version="1">MPNSSPTKPTAAVSDNRIPVTVLTGFLGAGKTTLLNRILSEQHGKKIAVIENEFGEVGVDNQLVIQSDEEIFEMNNGCICCTVRGDLIRILGRLLKRKDRLDAILIETTGMANPAPVAQTFFTDEEMREKFRIDAIVTVVDAKHILEHLGREDEAQSQVAFADVILLNKADLVAPAELDALETRLRNINAVAKLHRTQNCDLPLAHVLNVGGFNLSRATELDPKFLEIEYPFEWAGAYALEAGTHELVVGHCEHHDHHDAGHEAHEHGDAHAPHHDHAHGDHHHHHHGDENELDLLVLPLAAVAAPNQRATDHAATAAAIEVAIASFSDWETVLKAGEAILPGTALQRLALDDGHGHFPLKIPKSGNYLVVEQHGEIPLHIYKTANANDASGGTDHAAPRALVKPVWSQDFHAAHTHNDAVSSVGITAVGDLDGKRLNQWVSELLRIKGGDIYRMKGVLAVKGADKRLVFQGVHMLFDAKFDRAWASGEARQNTLVFIGRNLDRAALTADFHACMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH1</accession>
    <name>A0A139SLH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712011.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05380"/>
    <dbReference type="EnsemblBacteria" id="KXU35401">
        <property type="protein sequence ID" value="KXU35401"/>
        <property type="gene ID" value="AXK12_05380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="2">
        <location>
            <begin position="68"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="31150" checksum="248BE60445D0CE7E" modified="2016-05-11" version="1">MWAHMSDREWLWIAGELYLVGFLLGTWSLWRGGRPSTVLIHCLIAGGYVLQLVGLYLRGVAVGGCPLGNTFELFQFTAWSATTFYLITGVSFRSSILGYFTACLAAVLTLSSLAIPTWDAVRRANLFGGNPWIEFHAALALFSYGAFALLTLTAFMLLLRDHSLKHKHLGGWFSFLPPLTDLDQISTRLLAVGTALMTASLAVGAVYWVSAPHTVNLAKLMMTVGVWAAYCVTSLLRAKGLLVSRRFAWACIVVFVIALLSLGPVDSSRHALPPKPQGPTTEASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLM8</accession>
    <name>A0A139SLM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000041">
        <property type="protein sequence ID" value="KXU35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711937.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05160"/>
    <dbReference type="EnsemblBacteria" id="KXU35452">
        <property type="protein sequence ID" value="KXU35452"/>
        <property type="gene ID" value="AXK12_05160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="5">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="17995" checksum="51DC7C89EA439524" modified="2016-05-11" version="1">MPSFIIDVPVPSMGATATELNVIIIKVQAGDVVTKGQRLADLESDKSTFEFESPCDGTIHAVIGKPGATMQSGDPFVQIETSDESLRHLESKTESRAASTTHGANDGALASSGHGAAAAVQKGARELPVWTPKATRLAQEAGLDPTTITDIPATGPGNRVSGDDVQRYLEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLZ3</accession>
    <name>A0A139SLZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711921.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05120"/>
    <dbReference type="EnsemblBacteria" id="KXU35504">
        <property type="protein sequence ID" value="KXU35504"/>
        <property type="gene ID" value="AXK12_05120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299344" evidence="1">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="268" mass="29105" checksum="E7E5D0111F9FA56A" modified="2016-05-11" version="1">MIYGRRQFLNTSLLATAGLLLGANATPLFAATRSPAKAGEKTYTIKKGDTLSRIAKTHGVPLAQLKQRNALTNDRILTGQKLIIPAKAGTAAAATAAARAATALVPGSLADVIAATAKIQVNRSRWRHIVLHHSGIERGTAKTYDAEHRRRGMEYGLAYHFVIGNGRDSPEGQIAIGPRWFGQLRGGHVRNAQVNASGIGICLIGNFENRAPSAKQLAATYALIDWLRSGQVSPKHTLTVHRWVDKNHTVCPGRHFPFTELKRRYNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM14</accession>
    <name>A0A139SM14_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_04985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711865.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04985"/>
    <dbReference type="EnsemblBacteria" id="KXU35606">
        <property type="protein sequence ID" value="KXU35606"/>
        <property type="gene ID" value="AXK12_04985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="490" mass="51774" checksum="32858832FF68A194" modified="2016-05-11" version="1">MSSDLFQSLLSNAWAGLLVVLFFGGSIFVHELGHFLAARWCGLHVERFSIGFGPAIFSWRGKDGVEYRLSWLPLGGYVALPQLAAMDAIEGKSSVDVAKLPPASYGARMLTLVAGAAFNILFALALGCIIWAKGQPMSAPAASTTIGYVAPTLRLDDDAQGGSAGAAQVASPAAEAGLRAGDRILAIDGRSIKEWGDVLQGIVTGSGRTATGAPKTTFEIERAGARQTVTIYPQLSGPDQFRRVGIDSGYELIIHEVEPDSLAAAAGLAAGDRLLSLGGQRILNIATYLDVLDEAAAAPLTALVQRKVEGVAQEVALTIPPRSSPEARLGLAFTTDFALVHPNPIAQIASHARMTWRTLASLLNPQSDIGLSKMSGPVGIARILHSAAQISFVAVLMFTILINVNLAIFNLLPIPVLDGGQMLFATIARLRRRALPTSFVMATQSAFMILLFGAMLYVTVFGDIRRLFRDIADKPAAATQSAPANDTGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM23</accession>
    <name>A0A139SM23_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">AXK12_05060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711890.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05060"/>
    <dbReference type="EnsemblBacteria" id="KXU35618">
        <property type="protein sequence ID" value="KXU35618"/>
        <property type="gene ID" value="AXK12_05060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="409" mass="43624" checksum="0B3B372520F98331" modified="2016-05-11" version="1">MTHSVSEVTPRPSTASLYEAHVLGNYARAPITLVRGQGCRAWDDEGRRYLDFSSGVAVSSLGHCHPHWVAAVRAQAGELVHTSNLYRNPNQGELARRLVGYAGPGRVFFCNSGAEADEMMIKLSRLHGVAKSGGEEGRCFKVITARNGFHGRMFGGMSATAQEKVQKGFRPLVPGFVTAELNDLDSFAALMDEGTSAVLVESIQGESGIRPCTTEFLQGLRRLCDERGVLLMVDEVQCGLGRTGAFYAFEAAGIRPDAIAMAKGLGGGFPIGAVWIAEKFADLFTPGTHGSTFGGTPLACAAALAVLDVIEREGLLEKVSVQGREWLADLEKLVGEFPAQLSAVRGRGYLVGLELTSDPAPYVEALRERGLLVVPAGGNVIRVLPPLIATREELAESVGLLRAVFASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM29</accession>
    <name>A0A139SM29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711901.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35623">
        <property type="protein sequence ID" value="KXU35623"/>
        <property type="gene ID" value="AXK12_05010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="225" mass="24442" checksum="430819DC82CDEFCD" modified="2016-05-11" version="1">MCNIALPSLILAKLSAPERLGPALALVAALLFPLGYGLWDFAQRRSANFVSVIGLASVLLTGGLGLMQVDGLWFAVKEAAIPALIAACVWASQHSRRPLVRQFVYNEQVIDVARIDAALDAQPGSDNSQPAAQARFERLLRQTGQWLVGSFLFSAVLNFALARWLLQSPSGSPEFNAELAKMNLISWPVITLPSMAIMLAGLWRLLRGITQLTGLPLEAIFHARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM92</accession>
    <name>A0A139SM92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04885"/>
    <dbReference type="EnsemblBacteria" id="KXU35661">
        <property type="protein sequence ID" value="KXU35661"/>
        <property type="gene ID" value="AXK12_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="325" mass="35948" checksum="6EA447BD8F7124AC" modified="2016-05-11" version="1">MSQFIAHHYRHFNAASLVDAAKGYEAHLKAGGKMLVTVAGAMSTAELGISLAEMIRAGKVHAIVCTGANLEEDIFNLVAHDYYERVPGYRDLSAAEEEALLARHMNRVTDTCIPEMEAMRRIEKLILAEWMAADRAGERFFPHEFLYKILRSGKLKKAYQIDPKHSWMLAACEADLPIIVPGWEDSTLGNMYASHVITGEVKNVHTVRTGIEYMTWLAQWYTKTAKPLKNGEGSIGFFQIAGGIAGDFPICVVPMLHQDLGRTGVPLWGYFCQISDSTTSYGSYSGAVPNEKITWGKLAASTPKYIIESDATIVAPLIFNWVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB6</accession>
    <name>A0A139SMB6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711903.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05035"/>
    <dbReference type="EnsemblBacteria" id="KXU35624">
        <property type="protein sequence ID" value="KXU35624"/>
        <property type="gene ID" value="AXK12_05035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="493" mass="52999" checksum="E7A8667D54F38284" modified="2016-05-11" version="1">MILETLRARTWAVRSAALGAALFAAGLIGPLPYAFGQVPDTAAVRQAPDNAELLRLLEAQARRIEQLEERLSAVTAAAESDRVARQSAHEAAAPDAHVLLPRVEALETKAKAQPTLNWSRGAAPRLTSPDGSLSFRLRGRLFADVSGTGGSRFGELNNTGTEIRSLRFGAEGAYNQLSWVIEGDFADNTTAWKSAYLALGHKLFGKGAELSVGNRLEDRGFDGASGGGNVPFQDRNVVGLALQPARGNFGVGLTERITGEHWHASFAVTGNDLSNVGNNRDTVTYSTRAHLNPIKGERGTLHLGAWGLYEDIAKGDASGLRNWGQGGHFNDNAKTRPGALAEVTRAHAYGAELAGFFGPFWAYGEWGQRELKSAALGRRDYDAYALSAGWFLGGAKPSYNARAGTWGGVKVANPVTAGGTGAWELKARYESLDYTKLPTGGDGEAWTLGANWYLNNNSRILFDAVYWETNNRSGAYQGQDDGYTLNARFQVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA4</accession>
    <name>A0A139SNA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">AXK12_04415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711611.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04415"/>
    <dbReference type="EnsemblBacteria" id="KXU36068">
        <property type="protein sequence ID" value="KXU36068"/>
        <property type="gene ID" value="AXK12_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="24557" checksum="9DF8F17D0F1324EC" modified="2016-05-11" version="1">MTKAPAPPPASAPIIVAIDGGAASGKSSTARALAARFGLLHVDTGSFYRQVCAKLMAQRIAPDQTEPIEAGLAAVTFSTQVVGNTAQLLIDGHAAGDDIRSEQVNTHVSHYAALPAVRAALLAYQRSQPEVARKHGFRGVVMEGRDIGSVIFPNADFRIFLHADQAARAARRAAEGRVDAVAERDRLDTSRKAAPLLCPPGAVDIDSTHLTLEEVVEKLSALIAQKLPPLSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG2</accession>
    <name>A0A139SNG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="9" type="ORF">AXK12_04120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04120"/>
    <dbReference type="EnsemblBacteria" id="KXU36099">
        <property type="protein sequence ID" value="KXU36099"/>
        <property type="gene ID" value="AXK12_04120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="369" mass="41509" checksum="FD746D119A05B3F7" modified="2016-05-11" version="1">MLRVEGVLDIDRQRGGNGQLLDLSRGGKRRPDDTFVPKELIRRFKLREGSLIGGTAFPPEGRFPNPKMRFIETVDGVPLEERRSKFEFTTLTTISPEKHLKLETKDGRMTTRAVDLFCPIGKGTRGLIVAPPRTGKTTLLRDMALGVLENNPECHVMILLVDERPEEVTDFRRNVPAEVWASSNDEQIDNHIRVADLCIERAKRLVEVGRDVVLFVDSITRLSRAHNTLRNSGRTGSGGLDVRALEKPRQLFAAARNTEESGSLTIVASVLVETGSRMDDVIFQEFKGTGNMELVLDRKCAEMRLWPAINVAASGTRREELLIDPKLLDGIHFFRRALVQQRIEDATETMITRLSKTKTNAEFLKLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM4</accession>
    <name>A0A139SNM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_04505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711642.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04505"/>
    <dbReference type="EnsemblBacteria" id="KXU36084">
        <property type="protein sequence ID" value="KXU36084"/>
        <property type="gene ID" value="AXK12_04505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299338" evidence="3">
        <location>
            <begin position="33"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="67"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="229"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="729"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="976" mass="107307" checksum="9FB1D0E5B167EFE0" modified="2016-05-11" version="1">MTRFKPARFHCLFAFALLLPLTGLISRADAPAAETASALAASTNPAASLVPDPVLRTGELPNGLRYAIYPNKEPQGRASLQLVVLAGSLHETEEQRGLAHFLEHMAFNGSTHYPPGTLIEFFQRMGMSFGGDTNAFTSFDRTQYRLELPRTDADTLAEGLRVLSDYAGGLLLLDEEIDRERGVILNEKRARDSVAYRSFVAQFGAMLPAARLPQRLPIGLESVIEEAGRDRFVDFWDTWYRPERMIVVAVGDFDVEAAEGQIRDTFVPLVARAPARELPDMGRVTELEEPHLFYHYEPEAPGTDVILTWLRPYKEAPDSVEKRLAELPRNLALAMLNRRYSELAKGEDAPFNTARATAGDYYRFVEEAEITVSTNPKLWRKALQVGEQELRRALEHGFQPDELAEVVADFKNALAQSVRGAPTRHSSQLSSEIAEALFTDTVFTSPEFDLALLEAPLAQVTPEDCLAALREAFEGDGFYVSVIGNAKLSVDKSGNASAALAEQEILAAFQASHSEPVAPPAVRETSEWAYASWGEPGAVISDERVEDLDLRLVRFANGVRLNLKQTDFEKGPIYVSLRVGEGELTAPAEQAPGIGDLAGATFDAGGLGAHSADELRRILAGHTVGVGFTVGVDAFTLAGATTSEDLRLQLQLMTAKLTDPGWRPEALRQARKQLEQLYLSFKYTTGGPLVTEVANLLASGDPRFGLPEKDVMLSRNLEEAREWIDPELASGPLEVAVVGDFEPEAVIAAVAETLGALPQRAERRALDERKQVRFPAQPFNKNYGIPTEIDKGDVRVYWPSHDALDVRRSRRLSLLGAVLDDRLRLKVRQEIGGSYSPYAGNVASNVFPGYGYFQAICVVDPSQAEQIADLIVEIGDDLARNGVTADELERARQPVMTSVRDSLRNNTYWLRSVLSRAQEKPEVIDWARSRVSDIESITAEELSELAKTYLPATRASRVIILPERPAAAASDVPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN5</accession>
    <name>A0A139SNN5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">AXK12_04485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711636.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04485"/>
    <dbReference type="EnsemblBacteria" id="KXU36081">
        <property type="protein sequence ID" value="KXU36081"/>
        <property type="gene ID" value="AXK12_04485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="152" mass="16941" checksum="D10635A7161D80C3" modified="2016-05-11" version="1">MSSFVFPARSTTAEIELGTTLQPKFDADGLIPCITTDHLTNEVLMFAFMNAESLAHTLRSGKATYWSRSRGKLWCKGEESGNVQRVKAILTDCDQDVLLLKVESIGGVSCHNGYKSCFYRQLSEDADPSDEASLKLQFVARRLIDPAKLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP7</accession>
    <name>A0A139SNP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711462.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36186">
        <property type="protein sequence ID" value="KXU36186"/>
        <property type="gene ID" value="AXK12_04005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="83" mass="8966" checksum="0249C0302389E227" modified="2016-05-11" version="1">MSELIRLSTLAAGTRAVVREFPISGPSVVRLREMGLLVGTPLTLVRTAPLGDPIEIKVRGYFLTLRKSEAEHILVEQAAPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR8</accession>
    <name>A0A139SNR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711340.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03650"/>
    <dbReference type="EnsemblBacteria" id="KXU36243">
        <property type="protein sequence ID" value="KXU36243"/>
        <property type="gene ID" value="AXK12_03650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="144"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="514" mass="53766" checksum="1A61944826744F16" modified="2016-05-11" version="1">MSELPFDPLLLAILSPLAVALVIALGLPQRASVALACVGFGLPALLGLHTWYHFPSGLGAVAASGVGGAGGYAFQSFYDTGLSRFGIMLSLGLNGISMPLFAMAGVVGLAAGLYAIQSGAERLKTYLALLLVMQAGLMGVFASVDVFFFYFFHELALIPTFIMVGIWGGRDRHYAAMKLTIYLTLGAMLSLVGLIAIYVKSGAQTFDLIALRNALALQPLGESVQSYAFGLLMFGFGILVSLWPLHTWAPLGYGAAPSSAAMLHAGVLKKFGLYGLIQIALPLLPLGAAKWVGLLALLAAVGNVLVIGFVTMAQRDLKQMIGYSSVMHMGYAFLGIACLSTVGAGGVVLLMVAHGLSVALMFLLATSVHQRTQTFDMAEMGGLAQRAPVLAAFFVAATMAGIGLPGFANFWGELSIFVALWSFSKLFTVIAVAGIIISAIYGLRAVARVFFGSPSAQFTARVGGQPLADLGWAERLPALLLLGALLAVGFWPKSISEPVNDALQSTVSVAVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNT8</accession>
    <name>A0A139SNT8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711352.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03690"/>
    <dbReference type="EnsemblBacteria" id="KXU36249">
        <property type="protein sequence ID" value="KXU36249"/>
        <property type="gene ID" value="AXK12_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="169" mass="18598" checksum="B04A69579DC364F9" modified="2016-05-11" version="1">MNLKPETLQRIDEVITHYPVKRSATLPLLHLIQEDVGYLPEGTAEWVAAKLEIEPINVHGVITFYPMFRQKPIGRRHIRVCRTLSCALTGGYKVCDTLKEEFNAELGEVSPDGEVTIEFVECLASCGSGPVAMVDDELHERLTPEKARELAAQIRAESAIRASAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNV6</accession>
    <name>A0A139SNV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_03685</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711350.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03685"/>
    <dbReference type="EnsemblBacteria" id="KXU36248">
        <property type="protein sequence ID" value="KXU36248"/>
        <property type="gene ID" value="AXK12_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="450" mass="49380" checksum="4EDBF09E0BE654CD" modified="2016-05-11" version="1">MPAERRLIFQHIDEVGYTNDIDCYLRYGGYQTLKKAVAQSPEDLREEVKKSGLRGRGGAGFPCGVKWSLVDRKSGKPIYLIVNADESEPGTFKDRYIIHQDPHQLIEGIMISCFANGVKQAYIYIRGEFPKGAQILERAIAEARAKNFVGANILGSDYSCEIYVHRGAGAYICGEETGLIESLEGKRANPRIKPPYFPAVLGLYQCPTIVNNVETMCQVRHVIDMGGEAFSKTGTPGNTGTRIFCVSGQVKRPGYYEFECGKITMGELLYDVCGGPLDGRQFKAVIPGGSSAKVLRFGERFKGKRKLGADMVDYDWGVEDVPMDFDSLAAIGSMGGSGGVIVMDDSVSMVEALANINAFYSHESCGQCTPCREGSLWMKKISSRMVHGAARAEDAALLKSVADQIPGRTICAFGEGCSWPTQSFLIKFKDEFETYYEAKQSRAPEALQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ0</accession>
    <name>A0A139SNZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36224">
        <property type="protein sequence ID" value="KXU36224"/>
        <property type="gene ID" value="AXK12_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="75" mass="8244" checksum="861F5CA0AF89EC9D" modified="2016-05-11" version="1">MSHRGPAFTCADRMKPARLQTVFVGYIDNRGLTTEPYAPRIPVKAQLPLPNNTPLSRPSQTSLALKARLASRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP40</accession>
    <name>A0A139SP40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711261.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03425"/>
    <dbReference type="EnsemblBacteria" id="KXU36348">
        <property type="protein sequence ID" value="KXU36348"/>
        <property type="gene ID" value="AXK12_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18209" checksum="1C4C7D3DFFED4273" modified="2016-05-11" version="1">MLTSQVQVTVRYAETDMMGVVYHASYLPWLEIGRTTLLREHGLPYRMLEEMGYRLPVLEISAKYLRPAVYDDTVTIFTTMREKPILRLVLDYEVRRLSAAEDGPASAGSEGAQLGGTSDNSAQENAKGELLATARSIHAFIDKEGRPTRPPALFVEKMNAAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP73</accession>
    <name>A0A139SP73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_03395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03395"/>
    <dbReference type="EnsemblBacteria" id="KXU36343">
        <property type="protein sequence ID" value="KXU36343"/>
        <property type="gene ID" value="AXK12_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="201"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="445" mass="48690" checksum="6CD33EA211D57518" modified="2016-05-11" version="1">MKNLNSFLEQIRQRDPSQPEFHQAVEEVLMSLWPFVEKNPRYASAGLLERIVEPERVIMFRVPWVDDKGDVQVNRGYRVQMSSAIGPYKGGLRFHKSVNLGILKFLAFEQVFKNSLTTLPMGGGKGGSDFDPHGRSDGEVMRFCQSFMTELYRHIGASLDVPAGDIGVGGREIGFLFGQYKRLANEFSSVLTGKGLAYGGSLIRPEATGYGCVYFAQEMLKKRKLSFEGRRVAISGSGNVSQYSAEKAIELGAKVVSLSDSGGTVHIPDGLTTEQLAWVMDLKNNRRGRISEFAQHYKLEFLEGKTPWSLPCDIALPSATQNEINKADAETLVKNGCVCVAEGANMPSDLGAVEVFLKAKILYGPGKAANAGGVATSGLEMSQNAMRLSWNRGEVDNRLHAIMKSIHHSCLEYGTQKDGFVNYVDGANIAGFVKVADAMLQQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP80</accession>
    <name>A0A139SP80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease III</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nth</name>
        <name evidence="7" type="ORF">AXK12_03780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711371.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03780"/>
    <dbReference type="EnsemblBacteria" id="KXU36261">
        <property type="protein sequence ID" value="KXU36261"/>
        <property type="gene ID" value="AXK12_03780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="209" mass="23282" checksum="CAC4317C8BBF2241" modified="2016-05-11" version="1">MTIKAKAARAAYIDQRLAELYPETLIPLDHRDAYTLLVAVLLSAQCTDKRVNTVTPALWALADNPADMARVPVEAIQQIIRPCGLSPQKARAISGLSRILIEQHGGVVPHTFEELEALPGVGHKTASVVMAQAFGVPAFPVDTHIHRLAARWRLSSAKNVVQTERDLKKCFPRERWNKLHLRIIYYGREHCTARGCDGTRCEICQTLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP96</accession>
    <name>A0A139SP96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_03465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711290.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03465"/>
    <dbReference type="EnsemblBacteria" id="KXU36363">
        <property type="protein sequence ID" value="KXU36363"/>
        <property type="gene ID" value="AXK12_03465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="212"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="591" mass="64341" checksum="F7369226CBD8ABC3" modified="2016-05-11" version="1">MNNTSSPIASTHAERGPEMKGAEAVVECLVREGVDTIFPYPGGASQELHQALARTDKIRVILPRHEQGGAFAAEAYARASGRVGVCMATSGPGATNLVSAIADAFMDSIPLVAITGQVYSKYIGKMAFQETDFYGMTLPIVKHSYLITDVHELPRVFKEAFHLARSGRPGPVVIDIPKDVQQARFRPVYPQSVQFNNPYVGGTHEATDDQLKQVLALIASAERPMIYAGGGIISADASEELKTFAETTNIMVATTLMGVGAFPETHPLSMHWFGMHGAAYGNWAVDECDLLLCLGARFDDRVTGNTDTFAPKAKIVHIDIDDSELGKNKSVRLAIVSEIKHALRRMNALAAAAKFTAPDTAAWHAQVSKWKAEHPFTYTPGKHIQPQEAIEVLYELTGGDAIITTGVGQHQMWAAQFYRFDKPRRYISSLGLGAMGFGYPAALGAKVACPDKQVIDIDGDGSFAMNIQELATAKIEKIAAKAMILNNQHLGMVVQWEDRFYGSVRGNTVLGDRSNVGSPDNPDALYPDFAKIAEGYGVKARRVLKKSELREAIQEMLDHDGPYLLDVIVPYTEHVLPMIPAGKSVKEMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPE8</accession>
    <name>A0A139SPE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03505"/>
    <dbReference type="EnsemblBacteria" id="KXU36360">
        <property type="protein sequence ID" value="KXU36360"/>
        <property type="gene ID" value="AXK12_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="16157" checksum="A7820D165D1DB725" modified="2016-05-11" version="1">MHIHPVAASDQNTEARIYQYGRLGSSTSHLPYPDETLDHVPSVPIQTVRLDDWVAAGRVAAPDLIKIDVEGHGFSALCGMRETLAHHLPVIVFAVHDLRERDQGGALLRELGYTLTPASAASAESIADHAFGEYLCLPPGKVPNEKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPT5</accession>
    <name>A0A139SPT5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711202.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36615">
        <property type="protein sequence ID" value="KXU36615"/>
        <property type="gene ID" value="AXK12_03135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028963">
        <property type="entry name" value="Imm9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15587">
        <property type="entry name" value="Imm9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18450" checksum="D3D6DCB881EC8AB4" modified="2016-05-11" version="1">MKNKKVKQLSIGLGIEVVGLTKFADVFSTDKKIATYVKSILPRINIEDLSGWRLQLHISYLPTDSISVYKKFLRYPSDREYVILIGIPIPDNTQAPYGMPTGANGKISLFCRSAGDKHNHLLDPEYDKYADLNQYILAAAIKAIDLGFTKGFTCYGKKIKFQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ07</accession>
    <name>A0A139SQ07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711204.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03145"/>
    <dbReference type="EnsemblBacteria" id="KXU36617">
        <property type="protein sequence ID" value="KXU36617"/>
        <property type="gene ID" value="AXK12_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="619" mass="70544" checksum="669BC7FA4675439E" modified="2016-05-11" version="1">MCANNTRVHPRGADEPRAKMGGPARAWSWDLARQIERLDWLLEQVPRYADWGFTELYLHLEDAVQFPSLPNVARPGAYTTRQMERLVTRAAAVGIGVVPIVNLLGHTQYLIKVPELRDLNELRAPDGSPRPTGQICPLHPRTLEVAEKLLRDMQPFCTTPDRKVHVGLDESFDLGRHPRSRAEIARIGLAAHFARYVRKLRRLTRSLGLRMGMWADMLHFLPEAIPLLPRDLIAYDWYYYPFPRSPKIELFNFREIDLATPLISRGIEYWGCPMNGAFRHEPLPHFGDRLGNLASWERRCKEVGARGLLMTGWEPSRLAIETTQLVDAALAVKTPSPEERLTAGVARVFGTTPQQARKIAARLLTADRYPFTGYARWEINKDWSLATEISEARPNEERAFFKKAAKAAARWPKKLSALAASLRYRLYLAERDWFVRFGRSAADKKRFEHAITSGEAAARAMWAGSRRPDAHAPNLELIAADKQQLKRWSGADPGRSPWLRYTVWDFAPGLHWIAVDEWAHGKWQERKKCYTIEFLGAAAKRRGTLRHTHRVPLKTPGVKLRFRVGGLGEVKVGSVELSHSARIIRPKGWQRFRKLGSPTPSCGLFPDLTQEQCYALQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ92</accession>
    <name>A0A139SQ92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711154.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02890"/>
    <dbReference type="EnsemblBacteria" id="KXU36718">
        <property type="protein sequence ID" value="KXU36718"/>
        <property type="gene ID" value="AXK12_02890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="182" mass="19583" checksum="0E77404DB2CD61AE" modified="2016-05-11" version="1">MTRPAIILLMGASGSGKTTLGQALARELGWHFADADDFHSPANIAKMQAGHPLDDSDRAPWLAALRHHLAQSLAEARPTVLACSALKKGYRQRLLCGLPPHAVHLVYLRGSRDLLATRLAARTNHFMPAALLDSQLDALEEPGPEENALVLDIAPPPAELVSQMLKALRAPNALSHRPPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQE3</accession>
    <name>A0A139SQE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711169.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36734">
        <property type="protein sequence ID" value="KXU36734"/>
        <property type="gene ID" value="AXK12_02980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="26770" checksum="FBF5BCB02735E186" modified="2016-05-11" version="1">MTAALPVDSLPDGFSANAQKPLVYFILGASGSGRHAIASELAAVAREGGGGSTHVVEVMGETWPDWPQGAVAQVFVVADGRRNPVDQVEALKPWIEAHGAALGRILCVVSCQLAASTPALLPWFDACVHFSDVVLLNHREGVENRWVSDFKKRYAERFYPCLFEFVKKGQVTNPLVVIEPQARRISQYFDEREDPVVEGLIIETDTPDSDDDDADEAGAPAEDFYLARRAGGRRLHEIPDIAKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQF3</accession>
    <name>A0A139SQF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36744">
        <property type="protein sequence ID" value="KXU36744"/>
        <property type="gene ID" value="AXK12_03040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="76" mass="8256" checksum="B0054DF6E838344D" modified="2016-05-11" version="1">MECFQIWDFVGAQQRASKSQIERVQAQPAAPRVVEKKRSSAARVVGLGCNGFLAASCVSKPAALVVFSSLRLMRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQL6</accession>
    <name>A0A139SQL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF553 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711176.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36741">
        <property type="protein sequence ID" value="KXU36741"/>
        <property type="gene ID" value="AXK12_03025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007562">
        <property type="entry name" value="Transglutaminase-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04473">
        <property type="entry name" value="DUF553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF553" evidence="1">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="23617" checksum="869CFBB6BE5C05F3" modified="2016-05-11" version="1">MSSPAPRALLPRHRPRTTLARTAFPLGALALVAALVTLAGTALRAVTLDELLNDPKMTPKRFADHFTDFRFDSDPFFDVINPNQFLAQEAGDCIDYAALADYVLKHHGYKTRLIRVEMAGYKAGHAICYVDDSRVYLDYNNRSYFFNLTKSKPRIREVANKVAASFRANWTFAQEFTFSYDDYLKRAVYTVVKTRPPHLDPDAKRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQN7</accession>
    <name>A0A139SQN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711104.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02630"/>
    <dbReference type="EnsemblBacteria" id="KXU36925">
        <property type="protein sequence ID" value="KXU36925"/>
        <property type="gene ID" value="AXK12_02630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="34"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="694" mass="76355" checksum="03EE0105E7559341" modified="2016-05-11" version="1">MIGLRDDTDFGLQPPASLPNHAQKFAAQLFAEGGWLQETLSLEHRPEQESMARAAAAAFEGDTPLMFEAGTGVGKSLAYLLPGIIHAIDQSRQLIVSTHTIALQEQLEKKDLPLCRRLFSAVPELAPYATFQASVLLGKANYLCTTRLARALADRASLFADSDYEELQRIAEWAQTSENGLRHELQPPPRPEIWEAVNAASATCSRKNCDPTRCFYQRAKVRLRSSQVIIVNHALLFSLLNAGAGRAYAGTTESEARGILYADDFLVLDEAHTVPEVATENFGLSLSSYSVNRTLTALYNPKTSRGLLAKFGHPEGRQLVLDAAEAAQQFFALVHQQLLSTRTIVRVRDAETITPLLDGPLGALHRLILKTADQFDEGHDREELLEHAGRVRGLQKGVTEWLTLGDPGHVYWAERGGRRQTIIALRSAPIDIAAELRRQIFSGGTSVLCTSATLAIGGKMEPYAARIGAENTPSVIVESPFDYARCMRVFVASDVPLPSREDARLAIEVLGDYVRFCTERVRGGSLVLFTSYNDMRAVAAALEPIYLKLGRPFLMQGQDLSRTELAERMRAEGDAVLFGTDSFWTGIDVPGPALSQVILTRLPFGQPTHPIVEAKCEHIRERGGNPFAELTLPDALTKFRQGVGRLIRTASDTGLVTILDSRVLAKSYGRLFLGSLPTRNITRINRETRDEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQU4</accession>
    <name>A0A139SQU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36912">
        <property type="protein sequence ID" value="KXU36912"/>
        <property type="gene ID" value="AXK12_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="61" mass="7259" checksum="5F56D60AA7D3F2A4" modified="2016-05-11" version="1">MRDSLKRIEFENHDTRTVNLRDYNKNYWEIYALVPEPSTYGAVFGGAAVTLLLYHRRRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQW1</accession>
    <name>A0A139SQW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="9">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ileS</name>
        <name evidence="13" type="ORF">AXK12_02615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711102.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02615"/>
    <dbReference type="EnsemblBacteria" id="KXU36923">
        <property type="protein sequence ID" value="KXU36923"/>
        <property type="gene ID" value="AXK12_02615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="716"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="631"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="931"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="934"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="948"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="958" mass="106431" checksum="2ECFE4BD702C2417" modified="2016-05-11" version="1">MAQDLKDTLLLPKTDFPMRANLVQREPARLKHWEEIDLFAAMQQRRKASDKVFVLHDGPPFTNGDVHIGTALNKSLKDFVNRFKSMSGYRTPYVPGWDCHGLPIEQKVTAEIRAQNLQLTTAELRARCDAFSEKWIATQRAQFKRVGILADWENEYKTKAPAFEADIVHTFAAFVEQGLVYRSKKPVYWSIPFETALAEAEIEYKPHTSIAIWVKFPVPATEAARFALPTDKPLSVVIWTTTPWTIPANLAIALHPQIDYAVAETSSERLLVAQALLPQVAAAAKLDPAPAIIATLPGAKLEGLQARHPFIDRAAPIVLADYVTTDSGTGAVHTAPGHGAEDYQTGLKYGLEIYCPVGDDGSYLDDGRIPPDLVGVSTQETAEDAKAKKPSAANLAVLKKLADSGTLLAKARYEHSYPHCWRSKTPIIFRAVDQWFVSLDRTNGDAPTPRKTALTEIEKIAANGGWIPAWGEARIRGAVESRPDWCISRQRSWGVPLVAFYGPDKQPYLDAGVVRAVAEKIAQHGSNCWYAMTAAELLDGVTLPAHWPPAAELSCGRDTLDVWLDSGSTQAAVLRRGQGGTHWPADLYLEGSDQHRGWFQSSLWNSVIASGAAPYKAVLTHGFIVDKDRQKISKSSTYQKPQTAEAYIGQYGADVIRLWIASQDFRDDIPVDDEILKNVSESYRLFRNTFRFQLSNLFDFDLAQHAVAHESLDALDRWALHQCATLIDECTRAYSRYEFHRVYQLCNQFCAVTLSAVYHDILKDRLYTLGVNHPLRRSSQTAIHHLFHALVRLLAPILCFTTDEAWSYATAGREYAESDSVHLQDWPSAPAEWRDTALAADFDQLLSVRAQVSQHIEPRRAAGELGKSLDAVITVSGPLSSPAFDTLLRYRDSLPELFIVSQVALETSDSAKDDALQIRVRTGEEAGLVRCPRCWRWEPALDPESGICPRCTAALASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRB7</accession>
    <name>A0A139SRB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711037.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02240"/>
    <dbReference type="EnsemblBacteria" id="KXU37083">
        <property type="protein sequence ID" value="KXU37083"/>
        <property type="gene ID" value="AXK12_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="161" mass="17115" checksum="09B7BB44296BA934" modified="2016-05-11" version="1">MSPELTELYQQVILDHNRRPRNRGKLPSANRVARGDNPSCGDQCCVYIRLDGERIAELSFDGSGCAISQASASLMTTQLKGKTAAEAQTLFDEFKQIVTTGEAPEEMSDIAAFAGVSAFPARIKCATLGWHAALGALKSEPVSAESAADSGLAITTETHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRE7</accession>
    <name>A0A139SRE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711038.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37084">
        <property type="protein sequence ID" value="KXU37084"/>
        <property type="gene ID" value="AXK12_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="270" mass="29904" checksum="4C5B0B699FF9092D" modified="2016-05-11" version="1">MWSKLKEQFLVVIVTAVLVVGGAYWLHLQTVAGLAQSQQQELAPLREQNDALKAAAEESRRQIADMDQLLKDAISRRQADIFMTDEEIAKLNQEKVEALADAIARRVNPLGGLAATPEEAEALQNEQIDRVSSRMAQQIGPILAEMSADQNLTREAIEGYSQRISDQLGSVLTGELAKNQQLNNNLMETQAAAHDALKISHELTALYLSSQKDQGLIVRLLSLPANIVKDVAHLNIVDKRSKDKVAEELIEKMTALEARLKSLQTQQPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRI6</accession>
    <name>A0A139SRI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">AXK12_02280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711044.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02280"/>
    <dbReference type="EnsemblBacteria" id="KXU37090">
        <property type="protein sequence ID" value="KXU37090"/>
        <property type="gene ID" value="AXK12_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="98" mass="10684" checksum="ADF678CCD1E35A52" modified="2016-05-11" version="1">MAKVSIKPIGDRVLVQHIEEKEQVRGGIIIPDSAKEKPQEATVIAVGTGKKDEQGKNVPFEVKVGDKVLISKYGGTEVKIDDQKYTIVREDDILGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRI8</accession>
    <name>A0A139SRI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711022.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37153">
        <property type="protein sequence ID" value="KXU37153"/>
        <property type="gene ID" value="AXK12_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="290" mass="30603" checksum="F2914443304DE413" modified="2016-05-11" version="1">MKSDNDQPKVTLEQLLRVKRAEKPSPEFWAQFERELRMKQLAAIVEPRPWWAPFIRVGSRLARYQMPVGAAAVVALTLLTVRQYDTASPAEAGRAVVPQIAAEKVEKRGLTLAASADVAARGEAPVSLAADASELAGGAQRAPRASSVGSQALGAGMMLGGLASGLHAEASDEADSRSVAAQMVAANLEVVKTSESELVPLLELSLASQPTQLGKVAAVAARDPLSRVGAEAAQKRSSRLLGSALPATATVVASTASSSTLRLNRSISEERIYDSMRRGRLSADRVPIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRS3</accession>
    <name>A0A139SRS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711020.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37151">
        <property type="protein sequence ID" value="KXU37151"/>
        <property type="gene ID" value="AXK12_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299412" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1236" mass="129597" checksum="E47E97C14B88F86D" modified="2016-05-11" version="1">MHFKLTAYVSLVFACASGLVFGLFGVSSATAQIVLPVGPSVYHWDRGAGTDNWTDGANWYNSTSSSNNQVPVAGADLVFGNRPSGTDAQTVVLNSTNTAVRSIWFEAGRDYTFQGTGSLILGGGLANNGRLVTVFARGLPANHHTINLPISLAAGPAKTFEIANYSAGSILGFRGNFNLNGHSLRFTGTGPIYFEPSLILSNGASLSTVASSTTYPTILIIRNILLSGGNAATTQLTVGSNTLVIGRGLGTGVGVMVQSGGSYSMRAQSNVSGTLAGAGLARQAAAAPIGALYADGFISGRVNVSLVGNTSFGVRSGRGDAYVVTGGNVAVGTSSGFIKVDSGIVYFPSVDKGRQPAQNNLWQGVTAINGGVLRYGLASQNAWAGIVFTSTRLQLNGGILETDSNTAFTLGTGAGQVEWRGDGGFSSAVLNGAARAVILYTPGSSSPASLTWGTGFFVRTGRKLLLSSRYATGEIVFTNGIDLGSQLREVRVERGVRATLQGVVQENARARMSGALTGTNGGILKTGPGLLRLTGANSYTGATVIREGALRGNIPTSSNIRLSGGVLGLDADFTRPRFGPNGRIIWEGSGGFAAYGANRRVRIDNQTTTEIVWGSSNFVQSRQELRFGHYTADAAVIWDRVLNFGNAMRTIRVERGQALRGGAPNLTDVIFNRELRNSTKAGGLRLVGAGRADLAADNSSLNSDVLEISGAELAIATSNARLGAVGTIALSEGGRFTIRNVGSGSYNNAQVADTTKVTLNTGILRYEGRTTGNLPSVETIGDVTLESGANEIRLQHNLLAGNSYTELGVGEFKRASSSRATLDLTSNADVTGANASLYTYSATGKVRLRAAITTLSGQMIGGIAPWATINGTDWARRATTSGADYIANFASYTTGSTHSGNYRPSTAVTTFGPVTLNSLRLAVSSFGAPSRANLDGALTLSSGGLLASRVGPNTTAFHIIAGTGTLRTVGGRPLYTHVYGNGLEFTGSVRVIGGMDWVKTGPSRLRYISTGTSEIGSLYIHQGRFELVTGSINTGAAGQVYIGDGAGRDELWLSGGNNRLADRPKVTLRGTPYGRGAEFGAAEDQATLILRNGASQGLRELHIIDRGTIDFANGNPGAPNRLFLDLLTFNNSSARLFVRGWHEYEDFLLIKRTAFAAGQWPNLLSQIFFDGYSRDYELLLKDYDVNYYEITPWSSWATSALPEPSTYGALLAAAGIALVAWRKKRAAKASPLTATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRY4</accession>
    <name>A0A139SRY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37365">
        <property type="protein sequence ID" value="KXU37365"/>
        <property type="gene ID" value="AXK12_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="212" mass="23576" checksum="2839A33E7D20ABFD" modified="2016-05-11" version="1">MAAVLGGDKSNTFTGPVEVSGQYNVLSLAKTNGAIATRGDIFINNHAKLNTWGTRQIERNSTVRLRDAFFQFADHSDASFIKEECFHKLVAEGKSFLQFNWIGPLGKRFLYLDDLSIDSGAELVVSGWVEGTHFFLVRKTSSGLEDALKRIAFEGYIPGRTHLEHYNEDYWMISGTPEPATYGAGLMLAALGLVCYRRRQKQRSARLAAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS82</accession>
    <name>A0A139SS82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710930.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01695"/>
    <dbReference type="EnsemblBacteria" id="KXU37418">
        <property type="protein sequence ID" value="KXU37418"/>
        <property type="gene ID" value="AXK12_01695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="226"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="489" mass="52349" checksum="8764A0A6A95800E3" modified="2016-05-11" version="1">MTSPLSVDPETNQSPTALLGFLKQCREAARRARRAQLVSITIRVPALDPLAVLATIYEAGERHFYVERPSEDLAIAGAEAVLEFNASGPGRFAAVQDFVDQTLAAAIVVGGQGLPYSGPHFFTAFSFFNEVGPDEPFGSASVFVPRWQVATRGTGAARSTVAVANLVLAEDSDVEAACEKVWRAHQRFKGLGGSIGSRLFPEHFRDGPPTSGSQENGRSEGEGALYVNAVRSAVERIRAGEFQKIVLARAKDLRAAEPLHPMEALHRLRQRFEQCYAFSLANGAGQSFIGASPERLLRVHGGLLQTEALAGSAPRGKTPEEDFTLGEALLGSEKQRHEQRLVLDAIVQSLSPLGLQLEFAQMPELRRLDNVQHLHTPIRAALPVGIRALDVLSSLHPTPAVGGVPQAAACAGIRAIEDFPRGLYAGALGWVDGRGNAEFFVGLRPALIDGESARLYAGAGIVGASVPEEELAETELKFAAMEHALFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSA3</accession>
    <name>A0A139SSA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermidine/putrescine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710951.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01750"/>
    <dbReference type="EnsemblBacteria" id="KXU37438">
        <property type="protein sequence ID" value="KXU37438"/>
        <property type="gene ID" value="AXK12_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="393" mass="42924" checksum="9B663BA9BECCA87C" modified="2016-05-11" version="1">MISIRIDKLTKRFGAVTALAGLELEIAPGELFFLLGPSGCGKTTLLRSLAGFYTPEEGRIFFDAEEVTSLAPHKRNTGMMFQSYALWPHMSVAENVAFGLHERKIPKAEIAVRVAEALRSVHMETYADRRPQQLSGGQQQRVALARALVIRPRCLLLDEPLSNLDAKLRLEMRTEIRRVCKEFKLTTVYVTHDQKEALSIADRMAILDGGRILQAGSPRQIYKRPTCKTVAGFIGETDFLEGQVLGLDTDATSGETVATVETPLGRFEGVLGAPEKPPALGQTVTLSIRPECWNLSEATARLSSSEKSAHPAGRADKINSLRGRIGGCVYLGEVAQYDFVTEGGRGGSRNALPTTLKVFEKNPRRFIDGSDSGKAAGEVLATVEREDVVVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSA7</accession>
    <name>A0A139SSA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">AXK12_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710947.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01795"/>
    <dbReference type="EnsemblBacteria" id="KXU37433">
        <property type="protein sequence ID" value="KXU37433"/>
        <property type="gene ID" value="AXK12_01795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="23806" checksum="7BF637B3E1B76E21" modified="2016-05-11" version="1">MIIGITGGMGCGKSTAAALFAEHGFARLDSDALVRDRILREPEVLSAIHEKFGDGVFLTNSANGTTGMSGSGAGSERCFGELDRAWLAERVFACDDARLWLEALTHPRLFSLWREALCCAPPSTRWVIEVPLLFEKHLENWFDLTVCVASSSPQQIARLEQRGVVRELAEQRILKQLPLATKLSLADIVLWNDAALSSLQHQVEHVIAQLPHSPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSG9</accession>
    <name>A0A139SSG9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">AXK12_01910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710999.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01910"/>
    <dbReference type="EnsemblBacteria" id="KXU37411">
        <property type="protein sequence ID" value="KXU37411"/>
        <property type="gene ID" value="AXK12_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="39"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="598" mass="64688" checksum="BE1AE641D4A3B553" modified="2016-05-11" version="1">MKFWSQFFIPTLKESPADAEIASHKLLVRAGLVRKLGAGLYTYMPLGQRVMRKLTEICREEMDRAGAIELWMPHLHPAESWEAGPRWAAGREIMFRVDSAGEGAAAKLPREPELVLGPTHEEIITPLVKNEITSYRDLPKNFYQIATKFRNEIRPRYGLMRGREFVMMDAYSFDADEAGAAQSYEAMKRGYEAFFKRIGMHAIAVEADTGVMGGSFSHEFMAPAEIGDDDIIYCEASGYAANREKATSALVPADLADAAPVGEVEKFATPGATTIAALEAAPYGVPASAQFKTLVYVGDGQPFVVILRGCDELEEAKLGALGFTLVRPATPEEIEPIMGAKPGSLGAVKGRIQKPDALAGIFADHAIRLIGNGTTGANEDGYHLRNVNVGRDLAVTRFGDFRRVHEGEPCPRSGQPLKSRRGIEVGHIFVLGTKYSERFGAVYTDAEKQTHPMVMGSYGIGIGRVMQALIEQDHDGDGIRWPWAVAPFQVLVTLLDPKDEAAAAVAKTLAEAAERAGADVLVDDRDERPGVKFKDADLIGIPLRLTVGGRGLKEGVVELKWRSAVANQGSTEARKIPLAEAEAVIAAEVSAAAAVAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSS0</accession>
    <name>A0A139SSS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710880.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01430"/>
    <dbReference type="EnsemblBacteria" id="KXU37628">
        <property type="protein sequence ID" value="KXU37628"/>
        <property type="gene ID" value="AXK12_01430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="70"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="419" mass="44292" checksum="53F3D79C256C98CB" modified="2016-05-11" version="1">MERALLESVLRETGVAQKHGETLFLCDPYWSASQGQAAAAIVATGRGRRPSRVAIADEGAGYLPGWLAIPTGGSSGGLKFARHDERTLGAAVLGFCAHFDVERVNAVDCLPAWHVSGLMARLRCAATGGVHLPWDWKRLEAGDFPNLPPSACENGASSGLAGGWFLSLVPTQLQRLLKQGERAHKWLRAFHAVFIGGGPLWPSLADEAAASQLPIVLSYGMTETGAMVAAQRPGDFAAGDRSSGVPMPHAPVSINAEGLVCVRGDSVMRGYFGVEPCNGIFTTADLGRVDDAGRLHILGRRDEVAISGGEKVGLSEVDAALRSAKNSAGDTVFKDVAVLAVPDAEWGEVLVACYLNADAAPLSDAVIAAAMRDLARHQRPKRWLAFSPEAWPRNAQGKLNRAALREAVTDLHSAWGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSS5</accession>
    <name>A0A139SSS5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01685"/>
    <dbReference type="EnsemblBacteria" id="KXU37521">
        <property type="protein sequence ID" value="KXU37521"/>
        <property type="gene ID" value="AXK12_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="292" mass="31605" checksum="16FCB96715C2C8DB" modified="2016-05-11" version="1">MACAPRASTSTEAAPELLARIQAARAVVLSQVEFFHREFGRAKSRWKADGSRVTTADLAISENVARALLSRFEQDQCFSEELEDSTAPLPVTAKYCWVFDPIDGTNNYALGLSHSAISLGLLCDGVPVYGVIYDGARRVLMHGGPGFGVWDGERRVEPKPEGERKLSEASLIGFHSPYESRYAVQAAVLAEVAKLRALGASALHMAYVAVGLFDAVVDHNVKIWDIAAAVPMILATGGAVHYLTPPPFPLRNFDVNMGRIFCIAGNGPPTVSKLRQLLGVRRVTATTHSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST31</accession>
    <name>A0A139ST31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710882.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01440"/>
    <dbReference type="EnsemblBacteria" id="KXU37630">
        <property type="protein sequence ID" value="KXU37630"/>
        <property type="gene ID" value="AXK12_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="84"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="359" mass="39280" checksum="612C172D2CFF1AE5" modified="2016-05-11" version="1">MSYKLFIPGPIAVSEKTLRAMAQPMIGHRSTDFVALYQSIQPQLQSLFYTKDPVYLSTSSAWGVMEGSLRNLVAKKVLCCMNGAFSDKWLDVALRLGKQAGALRTEWGQAIDPEALRAELSQGGYDTVTLIHNETSTGTMSDLPAIMAVLRDFPDVLSIVDTVSSFSVLPIEKDALGIDVLLTGSQKALALPPGLALASVSPRALARAATLKDRGYYFDFLEFQKNHENGMTPSTPVVPLIYALKSKLEDIHAEGPANRYARHARLNARVRDWGRTNGFTLFPQDRYGSLSLNCFTNTREIDLPALNKLLKEEHALVIDGGYGKLKGKTFRISNMGDETDETIAVLLAALDAALAKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST33</accession>
    <name>A0A139ST33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710893.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01505"/>
    <dbReference type="EnsemblBacteria" id="KXU37641">
        <property type="protein sequence ID" value="KXU37641"/>
        <property type="gene ID" value="AXK12_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="444" mass="48255" checksum="CA5EDB7424A50F17" modified="2016-05-11" version="1">MNEPQKHVVILGGGFAGLNAARKLRAPNLRVTLVDRQNHHLFQPLLYQVATAGLAAPDIAQPLRHILARQRNVTTLMDEVQAIDLDKRQVTLGHGTLSYDYLIVALGARTGYFGRRDEWERYAPGLKTLDEATQLRRRMLHAFEQAETTRNTAEWSRLLSFVVIGGGPTGVETAGALVELARRVLTHDFRRIDPSKAHVHLVEAAPRLLLPFSPEQSEYTRRKLEAMGVKVHLGAPVTEVGPNHVQAGDLRIEASVILWAAGVEASPVTQTLAGVPLDRAGRVQVAPDLSLPEHPEVFAVGDLAAIVDTKNVRVPGVAPAAAQTGKHAAKQILAEIKGKARQPFTYLDKGSIATIGRSAAVAAVAKMRFNGWPAWAMWMSVHLFFLIGMRNRLIIFLHWAWAYLTWQRGARIITGINPSSDAPAPTPAASAAAASPPAPAPQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD4</accession>
    <name>A0A139STD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucA</name>
        <name evidence="6" type="ORF">AXK12_01290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710851.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01290"/>
    <dbReference type="EnsemblBacteria" id="KXU37825">
        <property type="protein sequence ID" value="KXU37825"/>
        <property type="gene ID" value="AXK12_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="586"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="954" mass="106034" checksum="7D45358726CE8794" modified="2016-05-11" version="1">MNSLPLPTQANAALIEQAYQSWLENPDSVDPTWRAFFQGFQLGYAGEPISGPAAQSVSIIDGLRQSHVHYLISNYRAIGHLEAHLDPLSEPPPAHPKLGLPYYKLSEADLDTVFDVGTYLGGGQMKLRDVVGSLRQTYCGKVGVEYTHIQDLDVRFWLQEKMETTRNQPAFTRGQKIRILRRVHKAELFEKFLHTKYVGQKRFSLEGGETIIAALDSLIEHCPDVGVEEIVMGMAHRGRLNVLTSVMRKSFDELFAQFSENYIPDTVGGDGDVKYHLGYTATLKTTTGSKVDVRLVANPSHLEIVDAVVEGKARARQRIRGDIDRTCVMPVLIHGDAAFAGQGIVAETMNFSQLAGYRTGGTVHFIINNQIGFTTDPSDARSSRYCTDVAKMIEAPVFHVNGDDPEAVCMVAQLALEFRVQFHRDVVIDMYCYRKHGHNESDEPAFTQPLLYRKISKHPQVSAILTRKLIEEGTITPEEGEAIKAEYTQALEAHLEKAKAGEGGRSEKRKARRDTIAQQMTRELSAPAARFQPSFDFEPVATHATAADIADITRALSTVPEGFSPNTKIRRLLDQRAAAIAKGEGIDWGLGEALAIGSLLLDGVHVRLSGQDCQRGTFSHRHAVLHDMETHETHISLRHIREGQAMFCVYNSLLSEAAVLGFDYGYATYHEKMLCIWEAQFGDFANGAQVIIDQFIASGESKWQQTCDLVLLLPHGYEGQGPEHSSARLERFLSLCAEDNIQVANPTTPAQYFHLLRRQMKRKFRKPLVIMSPKSLLRNPAATSRLDEFTSGHFQEILDDEIWGEPRSDAPPALDASSATQAALRTASGAGQQMKADTVRRLIFCSGKVYYDLCDYRAKNAITDVAIARIEQLYPLNAERLAEVAARYPEARLIWCQEEPHNMGSWNYISPLIEAITGRRPHYAGRAPGASPAVGSLALHHIELEAFLDAAFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STF0</accession>
    <name>A0A139STF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710820.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01120"/>
    <dbReference type="EnsemblBacteria" id="KXU37794">
        <property type="protein sequence ID" value="KXU37794"/>
        <property type="gene ID" value="AXK12_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="19991" checksum="9FC7C8CE2ADBF483" modified="2016-05-11" version="1">MANPLKCDLCEKPATVHLTQIVNSKVHKVDLCEECAKAKGVTDPTGLSLSDLLLGASLANASTSEGAAAALTHPFAPSPAILRCEKCGYTEVEFKKTGHLGCPDCYETFEPHIEGMLEKMHKGTAHLGKAPQRALARQNLHRRLNELNDALSEAIKTERYEDAARCRDEINEVKQAFGQEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STJ8</accession>
    <name>A0A139STJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710828.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01165"/>
    <dbReference type="EnsemblBacteria" id="KXU37802">
        <property type="protein sequence ID" value="KXU37802"/>
        <property type="gene ID" value="AXK12_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="175" mass="18702" checksum="0996162F7976C9E9" modified="2016-05-11" version="1">MPRQSPLPPPLFLETFATPIGPFSIATDTSGAIHATAFGEETALRKRLPAAAKPAGSAFKTPTRRSEARKQVEEYFRQKRHRFDLALAARGTAFQQRVWAALREIPFGETTSYGALAAQLGSPKAARGVGSANAANPICLIVPCHRVIAANGTLGGFAFGLEIKQALLAHEQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STK2</accession>
    <name>A0A139STK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_00820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710767.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00820"/>
    <dbReference type="EnsemblBacteria" id="KXU37938">
        <property type="protein sequence ID" value="KXU37938"/>
        <property type="gene ID" value="AXK12_00820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="9">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="218" mass="24428" checksum="EC80824DCB42EB63" modified="2016-05-11" version="1">MRRDLVLGIIASLLIHVGLWATSFWPDEPPPPPAIEAPPTIELMEMPELDLEPEEEEILESDEAAEVAEFAPPMQTDVPQLVSVDSFVQPVQPPPPQSLKPSAGAINIPTVRQTGLGKGVEIFDIRNLDQQPQPRFRVQPQYPFEMRRAGVEGEVLVEFIVDSSGEVRNPFIVRSSQRDFEQSAIQAVSKWKFRPGRKGGRNVNTRVQQLLSFTLQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STR9</accession>
    <name>A0A139STR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710804.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01040"/>
    <dbReference type="EnsemblBacteria" id="KXU37973">
        <property type="protein sequence ID" value="KXU37973"/>
        <property type="gene ID" value="AXK12_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="15"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="291" mass="32068" checksum="9E6D39CC7B4E3827" modified="2016-05-11" version="1">MSNIAHCVVDCHNTLGEGPLWDVREQALYWVDIFESRLHRLTPATGEVRHWDMPERIASVALRDQGGLVIAFASGLAFYDLDSSRLDWIARPEAHLPSNRFNDGKVDRMGRYWIGTLDESGPNHTAALYRLDPDLSVHKVLDGIGISNCLVWSRENDRFWFADSLDKQISVFDYDHSAGTLSNRRPFADTIGTDYTPDGGTIDAEGFIWVAVWGSGKVFRFAPDGRIVGEVHLPVSNPTSCMFGGPDLRTLYITSAAEGLTDEARAAQPQAGGLFAVDAGVAGLPETRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STS0</accession>
    <name>A0A139STS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710857.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01335"/>
    <dbReference type="EnsemblBacteria" id="KXU37831">
        <property type="protein sequence ID" value="KXU37831"/>
        <property type="gene ID" value="AXK12_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="190" mass="20312" checksum="0424A78B2AE830F6" modified="2016-05-11" version="1">MKPVPHPRHTLGLLAYLAAVLAVSFIHAPLVLSGLIGVVLVAAGRARWRLGRRSVLAGLGVTLCVGGGYVLMSLWRGEFHGLVVLRLALRVGLLTFLGCWFVSRGNLLRAVAFSPSLARLTAIAAGQVAVFTTLVRNFRLAAISRSGGLRLTWAQRLRQGASLSAQLMDKAVANAEQNTRALRARGVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU20</accession>
    <name>A0A139SU20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">AXK12_00715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710759.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00715"/>
    <dbReference type="EnsemblBacteria" id="KXU38073">
        <property type="protein sequence ID" value="KXU38073"/>
        <property type="gene ID" value="AXK12_00715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU38073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="194" mass="21727" checksum="2EE1ED873EFB6108" modified="2016-05-11" version="1">MKIGLYGGSFDPVHFGHLIVAQEAYERFGLDRVIFIPAAQSPRKPDTASASAEDRLAMVQAATQDDPRFAVSDIELRRGGVSYTLDTVRELKSRTPSDTFYWIIGADQAARLPEWHAIVQLAQLVEFIAVERPGSPALAPASVPGLRVQRLESRLIDISSTQLRERARRGLPLEYFIPHKALVYLKAHCLYREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU36</accession>
    <name>A0A139SU36_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710781.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00910"/>
    <dbReference type="EnsemblBacteria" id="KXU37951">
        <property type="protein sequence ID" value="KXU37951"/>
        <property type="gene ID" value="AXK12_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="360" mass="38578" checksum="0F3230C36C30419E" modified="2016-05-11" version="1">MACFYPEFSQKFAALLPELRAHGRVAIVGHMRPDGDCIGAQVGLARVLSAAGVREVTCLNADHVPRRLSFLTAQTRVLHAPEFLGNPDSDFRAGDYAAIFVDCADAARCGVELQTAFPKPFAMVDHHLSNPGFATHDFLDANSAATSEILAGIFLDLGLPIDEQTAQALYTGIVTDTGQFRFPSTTPRCFAIAGELIARGAQPAEIGYELYERESLGRLRLLEAFLKTLRLECSGRFCFGFLPKGIFEATGSTVEDTEGLVDYARSIEGVEIAALVEERVEAEWRGGGVKMKASLRAKNPIYRVDKIAAKFGGGGHACAAGLTAEADREAFCAELLAAVAEQLARVEASGGATNSEETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUF2</accession>
    <name>A0A139SUF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710747.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00705"/>
    <dbReference type="EnsemblBacteria" id="KXU38060">
        <property type="protein sequence ID" value="KXU38060"/>
        <property type="gene ID" value="AXK12_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="130"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="356" mass="38519" checksum="89B4AC8708270A0A" modified="2016-05-11" version="1">MRDYFLRRFLLIPPTLLGITLIVFLITRLVPGGPLERAIMEYQQVQSGSGGGAGSGASGAGGMGGPGSGAAGGQSMALSEEQLQQLKAYYGFDKPAIVSYGLWLGKVARGDLGNSYRYNEPVWQVIRERFPVSLFYGLITLVVTYAVSIPLGILKAIKHRSALDNATSVLIFVGYAVPGYVLGALLLLFFAARLEWFPMGGFVSYDFPDLSLWEKAGDLARHAALPLLCYLVGSFAVTTLLMKNHLMDNLAADYVRTAIAKGVSFRAAVLRHALRNSLIPIATTFGQNITLLVSGSFLIESIFDIDGFGLLGLQSIFDRDYPVVMGIIFLASLLLLLGNILSDALVALIDPRIRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH48</accession>
    <name>A0A139SH48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate carboxylase</fullName>
            <ecNumber evidence="3 8">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_00610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="LSZP01000065">
        <property type="protein sequence ID" value="KXU33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713379.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00610"/>
    <dbReference type="EnsemblBacteria" id="KXU33902">
        <property type="protein sequence ID" value="KXU33902"/>
        <property type="gene ID" value="AXK12_00610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0092">Biotin</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="14">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="116"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="532"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128134" checksum="70852678AA0EFBC3" modified="2016-05-11" version="1">MAANRGEIAVRIFRAGTELGLRTVAIYAEEDRLCIHRYKADEAYQVGHGLGPVAAYLDIPGIIALAKEKGVSAIHPGYGFLSENAEFARACAQAGIAFVGPRPELLEMMGDKTTARALAKKTQVPVLPGTEEPVTARKDAIRIAQKIGFPLIIKAAFGGGGRGMRIVHKPEELGALLEEAQGEAERAFGNPAVFLEKYIANAKHIEVQILGDQHGNVIHLHERDCSVQRRHQKVIEVAPSYGLPRDVIDSLCEAAVRIAREIRYDNAGTIEFLYDLDRHEWFFIEMNPRIQVEHTVTEVVTGLDLVRAQILIAQGHALHSPEVGMPRQADVPCNGYAIQCRITTEDPENKFVPDYGKILVYRSPGGLGVRLDGGMGYAGAVITPFYDSMLVKLITSGQSYEQALGRASRTLREFRIRGVKTNIPFLENVIEHPLFCNGQATTTLIDTTPELFRFAPRRDRATKLLNFLGNVIVNGHPQAKGYKPEKPIDWDAAQTTLRKNLASGSLKDGSRQRLLELGPRKFADWVLRQKPLLITDTTFRDAHQSLMATRVRSYDMLASAGTLARHAPQLFSLEMWGGATFDTAMRFLDEDPWERLRELRTRVPNICFQMLFRGANAVGYSNYPDSVVAGFVKHAAASGMDIFRIFDSLNYLPNLRVAMEAVQDTHAICEGTLCYAGDILDPSRDKFSLKYYVRLAKELERMGAHMIAIKDMAGLCRPYAAHQLVKTLKAEVGVPIHFHTHDTSGIAAASVLQASAAGVDVVDLAIASMSGSTSQPNLNSVVAALQHSPRDTGLDRVALDAYSDYWEAAREYYRPFDTAPKTGSAEVYLHEMPGGQYTNLKEQAAAMGVAQRWPEIARTYAEVNTLFGDIVKVTPSSKVVGDMALFLFSRGIKPADVVNLPAGETPFPESVIDMLSGGLGWPEGGWPVGVWRAVLGEAKFKAAQAKYRADTAAAKKPAKPRDKKATATLHAKELGQLRAEIAAKLHRAPEAVSDDELYSHLMYPQVFADFAKRTRDYGKVAALPTPAFFYGLQPQEEISVEIEEGKVLIIRLINVSESDAQGRRTVTYELNGMAREVLVADKSRAAKTQARPKADLSAPDQIAAPIPGLIVTMNASVGAKVAKGDRLFMMEAMKMQTSIYASEDGTVAELYAAVGDTVEAKDLIVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG1</accession>
    <name>A0A139SHG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713375.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU33920">
        <property type="protein sequence ID" value="KXU33920"/>
        <property type="gene ID" value="AXK12_08420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="470" mass="51655" checksum="416A0880F7BE350A" modified="2016-05-11" version="1" fragment="single">MKIGYDYTQPSQTPGGCGWHAHSLLVEMARLAPEAEFLAYRHFAGLFIHPEGRLAPLPPFPNIRDPLAGLPFEKVVKTWHEALANHEAPGEPDIVHSLLFQAPAQKKAKLVVTVFDLGFWVHPEFTTEGIRSGCQRGILDALENADGLIFSSEHSRQEFDRLLPHYRRKGEIPSIVTPLGCRYAPISNDVAKTNAARHGDYWLFVGSMEPRKNLVGLLDAYEAYAHEHPAPKPLHFVGGSGWKNEEIRARLAPLEARGLVKHLGVVADEELPQIYQNAEGFLFPSWYEGFGLPVLEAMSQGCPVICSDRSSLPEVGGDAVLYCDPAEPSTIADAMRRIEAEPGLREKLIPLGLSQASKFSWESAARQTLAFYEEILAAPTGTGMPQAATHNAASYTPKATPPSANTPQRNFWQKWFPSPKKNQERVDTLEAELTLLQQRLTQLESQGAASAAAAEQRFAQLESQGAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG9</accession>
    <name>A0A139SHG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713301.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34015">
        <property type="protein sequence ID" value="KXU34015"/>
        <property type="gene ID" value="AXK12_08275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="241" mass="26645" checksum="9F40EE44C8CFCC60" modified="2016-05-11" version="1">MNSLLTTITITGFTVAFLHAAIPTHWLPFVLVSRARGWQTTKTLGVVLLAGMGHIALTTLIGLLIAWFGFQLDHELEHVFGPLIGGVMIAIGAYFVWRQLRGKGVCHHAAPGSRHAKTEHCGHEHEDEPSHWEQELRESRLGADKGDWAAIGGLFLMLTLSPCEVFLPVYLSAVPFGWLGFVLLSAILAVATLAGMLLFTWLTLVGFERLRLRYFEQRESGLLGAIFMLLGVLLLFFPHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH3</accession>
    <name>A0A139SHH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713235.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08065"/>
    <dbReference type="EnsemblBacteria" id="KXU33983">
        <property type="protein sequence ID" value="KXU33983"/>
        <property type="gene ID" value="AXK12_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="198" mass="21182" checksum="A0339EC7B6535DC4" modified="2016-05-11" version="1">MNDGARLILASASPRRHELLAQIYPVFEVMPAEVEEQEDPTTAPRVMVAHNAAIKAAWVAERQPDAFVLGADTTVFIGNRVLNKPANAAEARAMLRELSGRTHTVFTGLVLTCAASGLTLSDYVTSEVTFKPLSEALIEAYLAKVHTLDKAGGYSIQEHGEMIVAARRGSLSNIIGLPLDETKQLLESAGLPCVSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH4</accession>
    <name>A0A139SHH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_08140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713260.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08140"/>
    <dbReference type="EnsemblBacteria" id="KXU33996">
        <property type="protein sequence ID" value="KXU33996"/>
        <property type="gene ID" value="AXK12_08140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="374"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="455" mass="48325" checksum="FAEAA44437B84DA4" modified="2016-05-11" version="1">MSKDTSINIGLCGFGTVGQGVWKHLEQNRAELAARLGAPLRIAAIAVRDPQRKRAVKLPPKLLREDPLEIATAPDIPIVCELMGGTDLAHRVTLAALRAGKIVVSANKALICEHGAEIFATARKHGGHFFFEASVAGGIPIIKALREGLVANRFPQIYGILNGTCNYILTQMEERDAPYAEILSEAKAMGYAEADESLDVGGWDAAHKAAVLAWLAHGLWVPPSRMIVEGIERVTPADFKNAATLGYSIKLLAIITRDFASNEVSVKVHPALLPDHDVIASVNGVYNAISVTGDVVGTTLYIGKGAGQDATASAVISDIADAVALLRSGKCVHLNSEVAPLPAEQASAGKSGEGSVAASAVTLAPLERIHGRYYLRLTVRDEPGVLAHIASIMAQHAVSIASVLQTPSEDPEMASLVLTTHDANERAMRDTLHELSRLKVVNGAPLLLRICEFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHW7</accession>
    <name>A0A139SHW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713138.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07785"/>
    <dbReference type="EnsemblBacteria" id="KXU34172">
        <property type="protein sequence ID" value="KXU34172"/>
        <property type="gene ID" value="AXK12_07785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029462">
        <property type="entry name" value="Rnk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14760">
        <property type="entry name" value="Rnk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnk_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="138" mass="15039" checksum="B296E14F5704E093" modified="2016-05-11" version="1">MNDTATNSLPRLRLTTADHDRLRLLVDTAIQSQPRLRETLAPLQAELKRAEVLAPADIPSNVVIMGATVQIEDKESGELDTYTLVYPEQADGAEGRLSILAPIGMAIIGFAEGDSFIWRTPGGTRQLYISKVIQPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI16</accession>
    <name>A0A139SI16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34186">
        <property type="protein sequence ID" value="KXU34186"/>
        <property type="gene ID" value="AXK12_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1251" mass="132365" checksum="66103A1DA488FA46" modified="2016-05-11" version="1">MPPDDAAVFFGALSSFGADLDAREEVVIAGGTSIGSLWFEGHEEGPGYTLSSDGGLTLGANVGDQEHIIAVADWYRSRETRIFAPTISIHSTAASTVRISNQSLAGLLISGQPTGINDPLATGSTFGIGSHKLQIRGGSMTHIASGLTGTGRIDVDTDRTQLILNANNSGWTNGSLNIVGHAIAVIKNSGALSATTTVNQFVTETELNPRSANGTLMLRSTLDTAPNGLTLAPKEIYVFSQGAGRSTNIDNPSGSDYRKAAGFSGAIYNDSGDNTISSAIKHSNPQFSALFPTWFYSRSGNLKLTGKIDIESSMFMKDGQGVITLTYADNVQFPDQGNKGTGGTQIVMGELRIENSHWALSGGFNAELSFATTLLLSGGVLGLGVDTHFTRKVSDGGWENGALPAGSVKWIGARGGFLARGTTEKTVNLTVSHGPPISSSVDNVTAGGRVNWHKGGFMGSWEHRFADKDTINMQNGGRLVLGSETYEGFLHWKNDIYFGNHAQFQAEYEALLADAGLDTNSRYTNQRVIEIQEGVAQMEGALSGEGFGLVKTGEGLLRLTSSASSYDGGTRIEAGALQGDVNNLNFTNLRLAGGVYMPNMKNRANEVFTVSLGTGNGEFRWLGSGGFAAGESSTTIRIGTDPESSLSWEDEHFLSDGSELILGHSLSSATLTWDKALETNGTQTVRVARGRLDSVDYDAVLNQSVSGTGLVIVGDGRLAMRAANALNTFSVRGATVTLNEAGALPGILVGGVLTGTQIFVRESGTLTLDNRTTDLAGRLGANSTLTLDGGTFRYRKGSGSGARDTETLGTLKLEGGSNTIAIEATGAMVLEFAGFDRNDDERATLDLISEAVFSPTGVRLQLPNAQNAFGDFGNMSPWATVNGTDWVSQDANGTITQLADYVTAAPGATWTTTSNINIGNTNRTLDQSRAVRSLRMGSGELNLAAGRTLTVDSGGLLFANGAAGKISGAGSLTTASGGTLYAHVYGSGSGGATAEINARITGGIDFVKAGPETLRLTSDGTSSFRNIYVHGGRLELDLGANGRINTTGKIIVGDRSGTDVLRLPKYNNQLTGERHIVLRGGNYGAGVLEFALKPAGLPGTTAFAGTTHRLKTLEVQGQGVIDFRGGEVGMANYLYIDELIIGVGSKLTIRNWFEGEDYLLVHRSKYDEYRYTDPSGLNGGILANTNQRVEFEGYSFLYIAHYNEDYYEVTPFPRQMATYFPEPSTYGAILGATGLGLLLWRRHKPRRPNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI25</accession>
    <name>A0A139SI25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713184.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34196">
        <property type="protein sequence ID" value="KXU34196"/>
        <property type="gene ID" value="AXK12_07950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="456" mass="51165" checksum="68045160583DC284" modified="2016-05-11" version="1">MRFSPGSAVIFCLAIASAVLVALIPYREPDGITFWTFATAHRDAYIEPIARWNEEHPPESRFTMTMLHTNVIENRMISGFLTGTPVADLLETHEDLYVRVYHGPLDQIGFLDITDRLHEEGLYEQYERTTLLQHTHRGRHFGLPITAASALLAYRSDLAEAAGISDEDIAQIETWDDYFRVMRPLMTDLDGDGRPDRYLLSLGDVSHETIRMLVLQNDGVLFDEDGNPSFANEQNARTLATLTTWITGPKRVATDVAAYTSTGHKQRLDGIVVGTIITNSLLAYWKRENPQLGGKIKLMPIPAFEPGGRRTSTAGSTMISINKRSSHIETAWELAKRLYTSIEVAEYLYRVVGMITPLKGNWDAPFYHEPDPFCGGQQTGTLFIEQLPHIPQSPASPYQNLAYAELVNAMIALRAHAERHGIYEVEPLAVEALRVLKKSQDALQKLIDRNVFLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIA4</accession>
    <name>A0A139SIA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713001.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07435"/>
    <dbReference type="EnsemblBacteria" id="KXU34302">
        <property type="protein sequence ID" value="KXU34302"/>
        <property type="gene ID" value="AXK12_07435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="293" mass="32852" checksum="4173C14D27A10FAB" modified="2016-05-11" version="1">MMKIEALSFHPIAGLCGRVRCEPGWNLSATWAKGLIDYDLWFVWEGRGTMITSTGEYALYPGVCLWMRPGHRYEAEQDPAARLGVNYIHFSARQQKSTLERNGTQQPVDNLPTSAFNPPFEILVSRQIELVDMLMRRIILLSGESQAEAANAALLTALLVELCREYTSGRAATEGGVSGTELYHYKVALESAARIRESPAEILSVAQLAREAGYSPDHFSRVFLGAIGLRPQDYLMRARLDRARQLLAETDLSVGEVATRVGFADIFYFSRFFRQHTGQPPSEFRRSLRRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB0</accession>
    <name>A0A139SIB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712973.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07345"/>
    <dbReference type="EnsemblBacteria" id="KXU34287">
        <property type="protein sequence ID" value="KXU34287"/>
        <property type="gene ID" value="AXK12_07345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="63"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="486" mass="51429" checksum="C7E843848AE9C4A1" modified="2016-05-11" version="1">MARKKRSSSVRKLLILLVIAGLGFGLWLRTQSSAEASAVFTTTTVERGDMSQIVTATGQLEPVTSIQVGSQVSGLITDVFVDFNSPVKAGQLIARIDPATYEQRLRQVEADLASSQASYALVHLNTERTRELREKNLVSQQELDQAEANLKQAAANLLTREASVENARVDLDRCSIYAPVDGIVLDRQIEVGRTVAASLNAPVLFIIAADLTQMQINALISEADIGQIVEGQRVNFTVDAFPNREFRGRITQIRNSPTTSSNVVNYQTIIQVTNDDLKLKPGMTANVSVIVAERQNTLRLANSALRARVPAALLPPAETTSSTTGATSPAPNNRDAMQQLMRDAGFTPGSGAPSPEVRARMQELAKERGITLPGGMAGGSGAAGAPGGPGGFGTRRRSPQSPDADAVTTRTVYKLGGSAQKPEVLPVTVKLGITDGTITEVIEGLEAGDKLVTSALITSGKAAKAVSTPAASASNPFAPQAPTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC9</accession>
    <name>A0A139SIC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mur ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712961.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07315"/>
    <dbReference type="EnsemblBacteria" id="KXU34281">
        <property type="protein sequence ID" value="KXU34281"/>
        <property type="gene ID" value="AXK12_07315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="501" mass="54179" checksum="17864AAB231B22FA" modified="2016-05-11" version="1">MKIYFMGICGTAMGNAALLARASGHEVLGSDAGVYPPMSTVLHEAGIAIHEGYAAGRLAALAPDLVVIGNALSRGNPEVEWLLDSRQIPYTSLPAWLAEFVLKGRRPIVICGTHGKTTTSALTAFLLRENGRDAGFLIGGVPVEPPVGQHLGEPSEPFVIEGDEYDSAFFDKRSKFIHYAPQIAVLNNLEFDHADIFRDLADVQRSFKHLTRIVPSSGYIVMNGDDENLAALGPIDWTRVVRVGTGAHCEVQLVDFSEDVNGAAFSLFWRGEVWAKVRWAQPGIFNARNAAMAATAAALAVCPDSPSSFDLGGLARFRGVRRRQERRVDTPELTVIEDFGHHPTAIAETLRSLRARYPQHVLCAAFEPRSNTARTSVLLEGFIAALSLADRVYLGATFEPRVEGAARFDTARVIEELAKKGVVAKTATRALAQSATRALAQSAGWREALLELMLQETLPALGESSEPGRLNRSPQLVVFFTSGSFAGIIEDYVSAAKALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE2</accession>
    <name>A0A139SIE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coproporphyrinogen-III oxidase</fullName>
            <ecNumber evidence="11">1.3.98.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AXK12_07700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:15425"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="1.3.98.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the anaerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.3" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713093.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07700"/>
    <dbReference type="EnsemblBacteria" id="KXU34348">
        <property type="protein sequence ID" value="KXU34348"/>
        <property type="gene ID" value="AXK12_07700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004558">
        <property type="entry name" value="Coprogen_oxidase_HemN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000167">
        <property type="entry name" value="HemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00538">
        <property type="entry name" value="hemN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="55"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000167-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="474" mass="52302" checksum="915CF5FBBADC20AF" modified="2016-05-11" version="1">MIISPELLQRFDVVGPRYTSYPTADRFTPSFAEADYAAALREMGRGAKALARKLNRSSAAISVYVHIPFCEQLCYYCACTKILTRQHGKAAVYLDYLERELALNIAQCGTGLPVSQLHLGGGTPTFFSDEALSRLMAMLRQQFQLLDEGEYSIEVDPRTVSPERLAVLRAIGFNRLSFGVQDFDPEVQVAVHRVQPAEKVFELVEAARQLGFRGINVDLIYGLPKQSRASFARTLGQIQSLRPDRIALYAYAHLPARFKPQQRIASEDLPVGREKLAILANAINTLSAAGYVHIGMDHFALPDDGLAAAKRKGTLHRNFQGYSTQPDCDLLALGLSAIAKVGSCYAQNEKTLAEYYAAIDAGRLPTVRGLVLTEEDRLRRAVIMAIMCQGRVDLAAFERDWPGLDFPKTFSAELRALCDLAAQGLVTLKEESGTASGFTLTALGWFFVRAVAMQFDRYLQPGRASSGTQFSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH6</accession>
    <name>A0A139SIH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712985.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34294">
        <property type="protein sequence ID" value="KXU34294"/>
        <property type="gene ID" value="AXK12_07380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="471" mass="52534" checksum="DFF1473BED8D2CB3" modified="2016-05-11" version="1">MTSSHTPSAQSPTSKKTGLARALPSGRILILFIAIVTSVIVALTPSEKREGLPFWTMRIRHYEAYEPKVAEWNARHPEKRVDMQLLHQSAFERRMLSGFLSGTPVADLLEVSSIVSPKAFLGPLDQVGFLDLTDRLHAEGVYDQFNEASFAPYTSRGRIFGLPHDVHPVLLAYRADLVEAAGIDVSQIETWDDYFRVMAPLMADHDGDGRPDRYLLEFSEIRPTEIIILMLQNGGEIFDADDRPAFANARNARLLATLITWVTGPNRRCLEVPPSSASGHRQRLDGAVIGTIAPDWMLGHWKIENPGLSGKLKVMPLPAWERGGRRVSVAQGCMMGISKTSTQIDLAWELALYLYTSAEVAEELFATNCIISPVKALWDAPFYDQPDPFFGGQKIGRLYIDYAPQIPIRTASPYTTSAEQAISTAAMALRAYADRNENYDIDALVPEAQRLLEKAQSELILFMSRNTLWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM0</accession>
    <name>A0A139SIM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712924.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00520"/>
    <dbReference type="EnsemblBacteria" id="KXU34428">
        <property type="protein sequence ID" value="KXU34428"/>
        <property type="gene ID" value="AXK12_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299304" evidence="6">
        <location>
            <begin position="24"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="66"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="295"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="749" mass="84249" checksum="786BC69A7209893F" modified="2016-05-11" version="1">MKPPKLLPIALSLCTFALGSLHAQQSPEQDDEEIVRLSPFSVSERADIGRYQAAQVSSGSRIRMDLMDSTQSISVVTSEFMQDIGTARLTDATKYVAGLSALGALPLSMDIMNVRGFSDYDLTLDGFTMFSLVNQDPIIVERIEFVKGPNAILAAQGLPGGVVNNISKKPLFTNKGYLSYQVGRYDANRAEFDANYVVNDKLALRVVGAFTEADHYRQGLFHQNTTAMPMFTYRLSPTTEFTLQFQIQKSDTLSDIAAPLSVYAVGRNNIHLPQNLPRDFQIAGRNSPQHQKSHNTRFFLTSQITDKLSMRVGGNWSQSDVRSNGPTPSAPYLGQTGIVVDPIRLNDITGEWYWDGSFNDNPTYKLSGLKEWPVRMRGNFQNDFVYEHTAANWKSQTVAGYAFNYISQHFRQRNYADDGIYYDFENNYTPPPYAFDPDIDWHFNSSDRHRGNQVYIYEVINLFDDHLVLSGSLSQNRYVSNIYDNLTGVRSDNRAEATLPAAGFVYKMTPGVSVFYGYSKQEVLVPGDPGQAIPSHTRPGRQHEGGLRLRLFDGRLYATATYFDILQENLWRNNPENHRTPIPFPLLPAVNTNVTSKGVEFELAWAPNENFSLIGSYTNFKFRDDDNMRGPNVPEETAAMWASYTFTQGALSGLRVGLGASYVGERASDAEGRWTSPPAGYDPVRIQPVFWMPSYIVAEASASYRFNKNWQVQLSIHNLLDKDYIAGSALRRVFVSTPINPKLTLRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM8</accession>
    <name>A0A139SIM8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712879.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00375"/>
    <dbReference type="EnsemblBacteria" id="KXU34407">
        <property type="protein sequence ID" value="KXU34407"/>
        <property type="gene ID" value="AXK12_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="2">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="357" mass="37971" checksum="5EE3FE6847FA9DED" modified="2016-05-11" version="1">MKFSQTYIESLAAALPDEILTSAEIERRLAPLYERLHLPEGRLELMTGIRERRLWPAGTRASDASARAGRAALAKSCIRPEQIELYIHAAVCRDMLEPATAAFAHRKIGLSPNCQIFDLSNACLGFLNALTLAASMIEAGQIRAALITCGEDSRPLVEQTLRTLNAEPLTRNGIKPYFANLTVGSGAVGAVVCHESLVVPEGLGSGGAAGESSRAHRLIGGVVRAATAHSELCQGETHGADSLAMQTDSEALLIAGVTLAHETWGQFCEETGWDAATPSRFICHQVGSIHRRKLYDTLGIDLAKDFSTFEFLGNTGSVALPATLALAVEKGVVRSGDKVALLGIGSGLNSLMLAVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIX0</accession>
    <name>A0A139SIX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34528">
        <property type="protein sequence ID" value="KXU34528"/>
        <property type="gene ID" value="AXK12_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="835" mass="88958" checksum="0F9069B2CF42BB46" modified="2016-05-11" version="1">MDDATQEKQQAQPQPLPNQPANSSATEVIDTAQEKGSAPSAPPAADLNKLDLSQLQGFSFGTKWESKPDDKRQAGRGDHNGGGRRDGGSDTGRARREFGDKRDTRRGDSAPAQRDRRGFRKPQGGSAPSDSLSSRGELQSGGAGQQERRSAVGAGERRQGGSGSYQGARRSGAGGPGGAGGAGGRFFQQHREALQPPYDSPYFAVSFYPEDTSFAALAKTIRSSYRTLELFEIARTVVAKNDRFIALLTRKPSAPTPSSSGDAQPASSAQNKSHREAAIYIARPDGVPFDSEEAVINYVVSQHIGQFFETEQVQVDPPKGNFQVINRCGVTGELLGPPNYHRYNQIVQQHFDARIKHLSFDAFRAKIETLRDEAVVAEWLEKMKTVTRYTWRGTGKKKTAPSSEASPPQTEPLRQETDSESVADVSESEKPSDGEAASTSHEAPAAENEAPKPEVAASAVEGSANDKGADEAAPPTSSAAEESSANSAPPEDGAAQAPSAAYFDSLEDAKVYLLTHARDKVYRTSDTARFHGNLLEKLPDGEIRRAIEGALERQRRFPLDTANGLRGRLRREHFTIFKKGSKGISYVCAVKRKFRTPGQTFADSISALIDFIEKHPMVLVSELPERFLGIKTQVAQPPSATTSTAGSSASEEALPAAPASHTQAEKAEVPASLSASDESTKDAVVEREALHRLQLDLRWLVTEGYVTEFIDGRLFAAPPVPESRKHAAENADAPDLENFPDAPKPKESSPEPSSLPQAQAEASSSVELSPATVSESAAGDGGGQEVAPEHSPEPSAREATIGAPAEAVPPSSSADSPSADSDSTITGAQPPSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIX7</accession>
    <name>A0A139SIX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712928.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34430">
        <property type="protein sequence ID" value="KXU34430"/>
        <property type="gene ID" value="AXK12_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="456" mass="51100" checksum="331027410C3736C4" modified="2016-05-11" version="1">MRLSLGSAVIFCLAIASAVLVALIPHREPEGITFWTFATVLRDAYIEPIAHWNEEHPPESRVSMTMLHPNAIEHRMISGFLSGTPVADLVETHEGMYPKIYNGPLDQIGFLDITDRLHEEGLYEQYDRTVLLQHSHRGRHFGLPLTASPAMLSYRFDLAEAAGISDEDMAQIETWDDYFRVMRPLMTDLDGDGRPDRYLLSLGEVSHDTIRMLVLQNDGVLFDEGGSPSFANEQNARTLATLTTWITGPKRVATDVHLNSATGHKQQLEGLVVGTIITNNLLGIWKRENPLLSGKIKFIPIPAFEPGGRRTSTTGSTLISINRRSSHIETSWEMAKNLYTSLGVVEYLYRVAGVITPYKAYWEAPFYHEPDPFCGGQRTGTLFIEQIPHMPQSPASPYQNLVYAELVNAMIALRAYADQNGIYEVEPLAAEAFRLLKKSQDALQKLVDRNVFISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIZ3</accession>
    <name>A0A139SIZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712799.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34519">
        <property type="protein sequence ID" value="KXU34519"/>
        <property type="gene ID" value="AXK12_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299310" evidence="1">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="205" mass="22801" checksum="AC9CCA875AEAFC6C" modified="2016-05-11" version="1">MKPYSTPPLLKSLVAALALLLVAALSPLTQAQAAMNASIPADIEFLDEVYSLAWTSDPAPNYSKAEYLPEDEELPYYYNMLLVERLSGATVKDVVRAQVDFIKGLRENEDPAAGGRILNLMENPNTGEVLLVFVMSAADEEREMIWEWNAYRYSPVQTANGEEAVQLFGYSVRHYGNDDSVYDFLEELDDANAERVNAVLSAQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ22</accession>
    <name>A0A139SJ22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acriflavine resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712833.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07225"/>
    <dbReference type="EnsemblBacteria" id="KXU34536">
        <property type="protein sequence ID" value="KXU34536"/>
        <property type="gene ID" value="AXK12_07225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112163" checksum="DA4061AFB710495A" modified="2016-05-11" version="1">MHFTDIFIKRPVLAVVVSLVILILGVQSYRALSVRQFPRSDVSVVTVSTIYIGASADLVNGFITTPLERAIASADGIDYMESKSGAGMSTITARLKLNYDPTAALAQITSKVNQVKSDLPPGSEEPLIDIAPADSNMADMYISFVSEDLELNQVTDYLTRVVQPRLSAVQGIQSANIEGARNFAMRIWLKPDRLAALNISATQVRQALASNNFLSALGSTRGEMVSVSLTANTDLRSVEEFRQLALRETGGAVVRLGDVADVELGAESYDSEVRADGHTAPFISVSVLPTANTLDVLGEVRKIIDSEIIPALPPGMTAKIVHDGSSYIQDAIKEIISTLAETMLIVVIVLYLFLGSFRTVLIPVVAMPLSLVGAVFLMLLLGFTVNLLTLLAIVLAVGIVVDDAIVVVENIERHVRDGQTPFEAAIKGARELVSPVIAMTITLVTVYAPIGFQGGLTGALFREFAFTLAGAVLISGIVALTLSPMMASRIIPADNHTSGFAAWLDTRFNGLRRRYARALRAWLVVPRFNWLVTLFVIIVVPLLLGPMFMFSQSELAPEEDQSFFGAILQPPPNASIEQMMLYADELESVYQAIPERADTFSVLGRGFAFLGLSLKPWSERERSTREIFQEASVKFQNFGGMEVFPFMPPGLPGGSSFPVSFVVASTAAPEQVNEVAQAVHQRALQSGKIMFAFTGLRFDRPETQVIIDRDKAATLGLDMQQIGADLGSLLGGGYVNRFSIQGRSYKVIPQVKRSERLNVEQLSEVHVTGPGGQLIPLGTFATFETSAQPRQVERFQQLNAAIISAQPLPGVTLDQALKVFEDAMREVAPSEYFMDYGGESRQLRQEGDTLTTTLILALVLIYLVLAAQFESFRDPFIVLLGSVPLAMFGALSFTFLGATSLNIYSQVGLVTLVGLIAKNGILIVEFANTLQIEGKEKLEALIEAASLRLRPILMTTAATVFGHMPLVFVSGAGAAARNSIGLVLVAGMAIGTLFTLFIVPSVYMAIARDHKKATEIEHQREVEAGLIVADPEAEPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ51</accession>
    <name>A0A139SJ51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712811.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34524">
        <property type="protein sequence ID" value="KXU34524"/>
        <property type="gene ID" value="AXK12_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299279" evidence="4">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="425" mass="45771" checksum="D664235BD1B7692C" modified="2016-05-11" version="1">MSLRFSLFLAALVSTTAHAVPSALSTPRALTLDEAIHHAWARDPQVAALALAPQLAQARELQAGLRPAPRLEANTALGLDDKSEWALGLGLSQSLPRRERVALARAYARLGGEAAPITLALRRTQLADKVRRLWYALAVQDARATLTEQMFAANRALADGLVERHAAGEIAESDWLFLKLELGRSAQAQALAKAERDATRAQLRARLRWPAAEPLPALQLALNPLLEVTLPEGNAGVASLPSLTLAEHEVAKARAALDLARSESREDWTVGAGVEVERRANDASGRLSSEPRLTLSTSAPWPVRSGRAPNRGVIAEREAALRIAQAELDALRDELAAEAHAALATARALQPEVLRYREFAQHAATAQQTLSPLLARGEISPRELGQAQQQHAAIEAEFLDAAARYLEARATLETALGQIPPQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJH2</accession>
    <name>A0A139SJH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712768.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07045"/>
    <dbReference type="EnsemblBacteria" id="KXU34691">
        <property type="protein sequence ID" value="KXU34691"/>
        <property type="gene ID" value="AXK12_07045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="131" mass="14737" checksum="D54FE6C28F3C00C9" modified="2016-05-11" version="1">MTKPITEPHQFSQLAESVIADFRRVPLHEPKRQRKRATKPLAELVEPLLAKYKIGRESAEQRLHAHWAELVGSANANYSHPVEIDARGRLLVLASHAVVRQELFHHRAQIVAKIQALPGCATVKHLNIRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJL5</accession>
    <name>A0A139SJL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712742.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06985"/>
    <dbReference type="EnsemblBacteria" id="KXU34765">
        <property type="protein sequence ID" value="KXU34765"/>
        <property type="gene ID" value="AXK12_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="696" mass="75738" checksum="F0536699C675C6BF" modified="2016-05-11" version="1">MLKLLIQTTGWLVAHTPECILRATTLGLAELVFALRRRLILSNLHHAFPEKSEAARRQIGRASCRQMTETGLLSLATPYLSLPRLRKIVTNTPEMNALVAAQRAAPRPHVLVTPHFAYWEAVTCFPIAVPKCETQGAVTNSGAPSVASSDQHVARQIESPAPFPEFAAVYRPMNNPALDAWLKSTRERFGIKLLSRRKGFQDAIGILRRGGAVSILYDQNAGDVGALTTLLGRVCATTELPGILAQKFSAPVVAVYARRLGFWRIAVQAEPVIPAGTSSEAVTLGLNRWLEAKLRGDAYARDSWLWAHARWKNQDKPERRLRLAAKRNLLSEGALKDSAHGVRLWVRLPNWLGDVVMLLPLLRALRISRPDAQLTLIGKAAFAPLIEDFGLAECFIPLPPRGGALGEVRYFAQFLKLRGSYPDCVLLFTNSVRGDLEAFLTRAPQRFGIARPGKPRPLLTHRYAVPLDYDEAQHHQLELWRDFLKTFGLEEAPVLTPIDAPAPTDAQTAGAAQAKWRAAVNEPAAPPLPPLGPLGLICGSENFPAKRWPIPHWVALIDALPRELPIRLFGTEKDRALTDQIAALAQRPVENLAGKTDLRTYCAALRDCAALVTNDTGGMHLANALGVPLVALFGPTNPVRTGPVFSAPVTILQPPNCPPSGGANLNELAPETVLAAVGACLGLRHTTSPTALQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR0</accession>
    <name>A0A139SJR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_06995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712746.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06995"/>
    <dbReference type="EnsemblBacteria" id="KXU34767">
        <property type="protein sequence ID" value="KXU34767"/>
        <property type="gene ID" value="AXK12_06995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="183"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="434" mass="48107" checksum="1F990806831CDC26" modified="2016-05-11" version="1">MLDPKLLRESSELVRAGIAKKHLDIDLDAVLALDATWRGLVSEVEGLRAQQKAANVAMAGLPKGTPEFLAKVQEMKAASATVKERETQLKETEEQWREALLSLPNLPHASVPEGRTPEENQVVATWGFEGIGPDGRPTLAPQNEERPRLAHFDIPGFERLFDFPRGAKVTGAGFPFFIGQGARLARALINFFLSENAKAGYTEVSPPILVNAASATATGQLPDKEGQMYETRELLYAVPTAEVPLTNFYRDEILDEAALPLRRCAYTPCFRREAGSYGRDVRGLNRVHQFDKVELLKWVHPTRSYDELEGLRGDAESLLRKLELPYRVLLMCGGDLGFAQAKKYDLEVWAAGQGRWLEVSSCSNFEGFQARRAQIRYRSAETGKPEVVHTLNGSGLAVPRVLAALLENNLQADGRVKLPAALVPYFGDEYLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY3</accession>
    <name>A0A139SJY3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">AXK12_06545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06545"/>
    <dbReference type="EnsemblBacteria" id="KXU34888">
        <property type="protein sequence ID" value="KXU34888"/>
        <property type="gene ID" value="AXK12_06545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="159"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="663" mass="73971" checksum="B4CA34ED6A60AA5D" modified="2016-05-11" version="1">MSADDLHLFNEGTAHRIYDKLGAQLCVHEGVAGVSFAAWAPNASQVWVVGDFNGWDGAAHPLRMLGSSGVWERFVPGLGAGVLYKFQICDRSGHSQLKTDPYGQSFEAAPGNAAIVCDTRSYQWGDAEWMQARREGAVSRSSESGAARETLDRPISIYEVHLGSWRRDPSEPDRLLSYRELAPQLADYAVEMGFTHVEIMPIAEHPFDGSWGYQVTGFYAPSQRYGTPEDFAWFVDHLHQRGVGVILDWVPAHFPRDAFALAQFDGTALYEHADPRQGAHMDWGTLIFNYGRNEVRGFLAANALFWLERYHIDGLRVDAVASMLYLDYSRASGEWIPNQYGGRENLEAIAFLKHVNGLIEHYHPGVLRIAEESTSFPGVTRPLAEGGLGFDFKWNMGWMHDTLHYFAKEPVHRKWHHNDLSFGMLYQYSEQFITVFSHDEVVHGKGSLLLKMGAEHIPEKAANLRALYAHMWAWPGKKLLFMGGEFAQSAEWSHNRSLDWHLCQYADHEGVRRLVRDLNQLYRSEPALGTSDLSPEGFQWLACYDTDASVIAYLRKASAAARPSVGGAGGDASAQSRRSCAALIAIVGHFTPVVREHYRVGVPQAGLWREILNTNSAHYGGSGLGNDGARHTEPIPADGHPQSLLLTLPPHTVLFFRCEVGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK43</accession>
    <name>A0A139SK43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">AXK12_06365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712646.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06365"/>
    <dbReference type="EnsemblBacteria" id="KXU34925">
        <property type="protein sequence ID" value="KXU34925"/>
        <property type="gene ID" value="AXK12_06365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="20601" checksum="465BD65FC304BEBD" modified="2016-05-11" version="1">MSNHPILSDAKARMQKAIDHTLHEFSTIHTGKATPAMVETIVVEAYGTTQPLKACAAISTPDARMIQIQPWDITLVQAIAKAIQQANLGFNPIIDGKSLRVPLPEMSRERRQEFAKVAHKLAEEGRVQVRNVRRDAMDSLKKDAALPEDERKRHEKEVQTLTDSAIKDINQHLEHKEKELFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK60</accession>
    <name>A0A139SK60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712549.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06475"/>
    <dbReference type="EnsemblBacteria" id="KXU34877">
        <property type="protein sequence ID" value="KXU34877"/>
        <property type="gene ID" value="AXK12_06475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="141"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="358" mass="38165" checksum="7ECDB1C70A7D66A0" modified="2016-05-11" version="1">MQTHASIQARPPLSRRARTLWLAGLALVMAAIFSVDTTTHYEVAAAVFYTLVVLIAARVLRGRALLWLAVWCIGLSVFSFALTPHGDLHAGLINLAISITAIIMVAWLVIKMEAARDAAHAAQAQLLRLARVKRLDGLTTAIAHEVNQPLAAIVTSGHACQRWLGQDPPKLAKAELALNRILADAARASQIVTRVRSLSRGEPVQAVAFDFNAAVMEVLALSTDELERHGIELALELAGNLPRAFADPVQIGQVIGNLLLNAIEAMADKPDKAHVLRVGSILKEDTMILTVADSGAGIPAEIQAHLFDAFWTTKADGIGVGLSISRTMIEANGGQIWAESAPNGGAVFSISVPVEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKK9</accession>
    <name>A0A139SKK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein AXK12_00265</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712390.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00265"/>
    <dbReference type="EnsemblBacteria" id="KXU35037">
        <property type="protein sequence ID" value="KXU35037"/>
        <property type="gene ID" value="AXK12_00265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="102" mass="10795" checksum="C29F56C373018DAC" modified="2016-05-11" version="1">MAGLGKLLKQAQKMQRGVEALQAQLDAHEIEVSSGGGAVQVKVNGNGRFLSLSLDPEFLKEEPAFVSETILGAIQDAAGQAKTYNEAEMQKVTSGFSMPGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW1</accession>
    <name>A0A139SKW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35208">
        <property type="protein sequence ID" value="KXU35208"/>
        <property type="gene ID" value="AXK12_05755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="32094" checksum="58C16966F454F905" modified="2016-05-11" version="1">MSASTESANKRVGVIATLAMIGSAACWGFATVMSRDLLNSFTAPLLLVVQLIASVLTLLLLSMPHKPWRYISPSLGRASLTGILEPGLTYSVGLWGLSLTSAGSASIIGSTEPIFILVLAWIIFKEKPSANLFACILFAVTGLLLVSYDSATSNANKSLAGDLLIVLSTLFAASYVVLSAKWANRFPAAVLASSQQFIGLMCAISIYIAGTVSGMINQSIFEVRLGTIIYASLSGIIQYALAFWLYLIGLKYLRPGAAGLWLTLIPVFGVAGAFIWLGEVPTVTMLAGMVLIVVAVYAGRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX7</accession>
    <name>A0A139SKX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712173.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05780"/>
    <dbReference type="EnsemblBacteria" id="KXU35211">
        <property type="protein sequence ID" value="KXU35211"/>
        <property type="gene ID" value="AXK12_05780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="214" mass="22850" checksum="335BB28B551A40A0" modified="2016-05-11" version="1">MSFKTILLDLDGTLVDAFTTIHRAYCHTLPQFGKPAPTLDEVRRAVGGGLRDAMGHFLPQDQIDAALPIHRAFTQKILLDDLRPMPGALELVRDLHTRGVQLAVYTNKDSATSRRVCAHLGLTPLLAGIYAAGDTPWLKPEPELAAHVLRELGASPKSTLLVGDSPFDVEAAHNGGFLCWAVTTGTHSANALLAAGAARVFDGLPALHAALRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL22</accession>
    <name>A0A139SL22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35249">
        <property type="protein sequence ID" value="KXU35249"/>
        <property type="gene ID" value="AXK12_05995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="281" mass="30637" checksum="129DD1945982609F" modified="2016-05-11" version="1">MLDVANVNEADLAAAAEAYHRDGYFIARGLFSPEEIADINAVFHKMHADGGVPGFYEPGKPSPAEMKLANYKEDPLVIWTRVMHPHRFNEKARAYMLHPKVRVYLEKFMGGEPVATQSMYFFKAPGSRGQAMHQDNFYLLVEPGTCMAAWTACDDADPENGGLMVVPNSDSNELVCPGVADNTVSMAPHRVPIPKGQRVVPAVMKAGDTLFFNGNVIHGSGPNRSKDRFRRSFICHYAKGDLARISKYYDPVVAMDGRDITKEANNGGGPCGGAWEGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL29</accession>
    <name>A0A139SL29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the porin LamB (TC 1.B.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05875"/>
    <dbReference type="EnsemblBacteria" id="KXU35227">
        <property type="protein sequence ID" value="KXU35227"/>
        <property type="gene ID" value="AXK12_05875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034219">
        <property type="term" value="P:carbohydrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003192">
        <property type="entry name" value="Porin_LamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036998">
        <property type="entry name" value="Porin_LamB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02264">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="315" mass="35545" checksum="2BEDA43E3174846C" modified="2016-05-11" version="1">MAEALLTWRNLSWLNGGAIIAGRSMLHYKSADVHINDFFYRDMQGVGFGVQDVQLGKVKATYFLSRKDNPYQEYYVNRHDLFFEGLETNNGGTLEFGLNYVEKDTHRADTTWGWSTHVRHIQKIGETGNNSLALQYGEGPGTALGYTGDLYLNRSNNRWRVVEAYDWQGEKLGGQVIGIWQRDRFNTGDTQDWVSVGGRATYSLSERIKLSLEIGHDAVKPSGAAQRNMTKYTFAPSFSPKGTKFWSRPDIRVFYTWAHWNGAAQSAADFVVPGGALSRTGVFGSARHGGSFGVQIEYWTDGYQPVRETIKYMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL33</accession>
    <name>A0A139SL33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_06120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712308.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06120"/>
    <dbReference type="EnsemblBacteria" id="KXU35271">
        <property type="protein sequence ID" value="KXU35271"/>
        <property type="gene ID" value="AXK12_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="281" mass="31126" checksum="9BD93982DBC1E4EE" modified="2016-05-11" version="1">MSSTASTTAIDHHHDHTTCTGIPNKKLMMWAFLASDCMFFGCLIATHLIYRLHPPPDAPDVRSIFSIELTSFSTFILLMSSLMMALAVNAIQKNNLKSLRTTLLTTVFFGTIFLGCQVYEFQHFVHEKGLTITNSILGTTFFTLTGTHGVHVAIGVFWLILMYVRSFQPRDTAADRGWFWRGLLHIAAVIGVCLGAMLFVIELAHGLLAGNGLGGALAHSIGWLIGAAASTGVALWLARPRGLVDFDERNAIDVEMMGLYWHFVDIVWIVIFTAVYLLEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL59</accession>
    <name>A0A139SL59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06030"/>
    <dbReference type="EnsemblBacteria" id="KXU35283">
        <property type="protein sequence ID" value="KXU35283"/>
        <property type="gene ID" value="AXK12_06030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="36482" checksum="C6B12474DC537951" modified="2016-05-11" version="1">MERGEAPAIEVHDLVKTYAGTTAVDHISFSLPRGEILGFLGPNGAGKSTTMRILTGYLPASSGRVSVCGHSLTSQLAEVKKLIGYMPENNPLPEDMRVHEYLYFRGRLKEVPRRTLGPRIDEVLELCDLKRVRHKIIGKLSKGFRQRVGIAEAILAEPPIIIMDEPTIGLDPHQILIVRDLIASLRGRMTVIISSHILPEIEMTCDRVLIINQGRIVAQGTPEELRRSVIGHSHYELEAAGDPSRLSEACGACDESLQIEARGEPDATGFRRWLLTTKREDPLGEGLLKTLGEAGFRVRSLSRSQPTLEDVFLAATRRSWDVTAEDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL71</accession>
    <name>A0A139SL71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712212.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05850"/>
    <dbReference type="EnsemblBacteria" id="KXU35224">
        <property type="protein sequence ID" value="KXU35224"/>
        <property type="gene ID" value="AXK12_05850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="251" mass="28337" checksum="D3D01C61E1A64251" modified="2016-05-11" version="1">MKLVSWNVNGVRAALGKGLLDWMQASDADVIFLQEVKALPGDVQGVSWPDGYRLYWNAAQKKGYSGTALFTRTEPLSVQMGIGSAEHDTEGRAICAEFAEFWFVGVYVPNAQDGLARIGFRQAWDRAFLDYVRDLEKTKPVIFCGDLNVAHEEIDLARPKENVGNPGFSDEERDGFRDYIAAGFVDTFRHFEKGGDHYTWWSYRAGARPRNIGWRIDYFMTSASLSPRLKRAWIEPEVMGSDHCPVGLEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL83</accession>
    <name>A0A139SL83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712092.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05555"/>
    <dbReference type="EnsemblBacteria" id="KXU35313">
        <property type="protein sequence ID" value="KXU35313"/>
        <property type="gene ID" value="AXK12_05555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018677">
        <property type="entry name" value="DUF2157"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025513">
        <property type="entry name" value="DUF4401"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025833">
        <property type="entry name" value="GDYXXLXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09925">
        <property type="entry name" value="DUF2157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14351">
        <property type="entry name" value="DUF4401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14345">
        <property type="entry name" value="GDYXXLXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2157" evidence="3">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4401" evidence="4">
        <location>
            <begin position="372"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="889" mass="96668" checksum="095AB7605C76DACD" modified="2016-05-11" version="1">MSPAEASPAPQAGSPHSSPAHSDARRWQLLGNRLLAFLGAALLAAALIFFFAYNWAELHRFAKFAVGFGAFLTAAAFALTSTGRRQNGAAPNLEARTARRRAALFAATLCIGALLALIGQVYQTGADLWELFALWALLVIPFALLARSVETWLLWLSVANTALILWLNQTEAFGRHTNALAGHLLCCVAFNTACLLLAERFARARPFTPNRALPRVAAFLALGELCVGACVGVFSEDFAHLIPLFIAAAVLMIALYRHYRFDLVMLAMSGSGAIAFGTVALARILRGIPLELSSILCASFLIVSSGLFIAWLIQLHRSQKPQSPDAKQPTRDALPIEASTAANQTSADPVTTPATAPTTTAPSPSKKEPAPPLWLSGLQGIAAWIAAAMLASSLATPFWLFEGGVWFIALAFIGGSIALFYKVRNLVFFDQAALALSFAGQALLYVSFSEHWNDLSDKGALTLSIIVALALFALRTTLLHRTLCLLWAITCLYLIVEPGYETHVLFGLGFSTLTILLWLGRPRWTAHKLGEYVLSLAHASSLIAWGLLGWNYFYNHVIFWKHPEAPHDFALLYSTVSAAILVGLVAWLCRPLYANADAPERAKKQAALLLCAAGLFAALAYRDPALVLCAALLLGTYAARERSWFTAMLGALPLLIWQLYYNMEQTLLMRALTLAGSGALLLGLRKAIALLALDNLTAPLRTEAVPLRRKETGDCALFGPFQRGTAAAAALVLALCLWGIWSNERVLAHGRPILVKLAPVDPRSLMQGDYMRLRYAIEHDLLLHMPQGWKRIPRSSYAYVVLDEQGRAITVHSIGSQLTPLPEGASLAVKLLGKPYSPSIAAKEFFFQEGRGEIYETAKWAELRVAPSGKALLLNLRDESLEILGETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLD0</accession>
    <name>A0A139SLD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712048.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05445"/>
    <dbReference type="EnsemblBacteria" id="KXU35294">
        <property type="protein sequence ID" value="KXU35294"/>
        <property type="gene ID" value="AXK12_05445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="107" mass="11506" checksum="A9ADCF5F55A8C679" modified="2016-05-11" version="1">MAWIYLVIAGILEVVWALGMKQTEGFTRLWPSVFTLGFMAVSFYLLALAMRDLPAGTAYAVWTGIGAVGTVILGILWLGEPRDAARLICVSLILCGVIGLKVFSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG3</accession>
    <name>A0A139SLG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05270"/>
    <dbReference type="EnsemblBacteria" id="KXU35382">
        <property type="protein sequence ID" value="KXU35382"/>
        <property type="gene ID" value="AXK12_05270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="544" mass="61231" checksum="F38ACA3989DB188F" modified="2016-05-11" version="1">MDFYGNNGSHESIHDFEDRIELDIDEIELIPHGGRSSDGIFPFFALTDQHDAFAIGIGWSGRWCAKLRHAAGALQVEVGLPQVGFVLRPQESVRLPSVLLARAPGASADQARRVVRSHLTHHVRPKAPDGKSPLFTSHGTMYRFHVTRIANEQGEIEALERAAAMGIEAYWVDACWYGNLPDWAKEVGNWYARRSDFPRGLRPISDRAHELGMKFIFWMEPERVRPDTEWARTYPDLLLHYPNDDKRHPWYRGDMLLNLGDPRAVDLAFETVSSLITEFNTDIYRQDFSGYPLDAWYAADAPDRVGITEIRHIEGLYALWDRIRAAHPGILIDNCAGGGRRIDLETLRRATVLTRSDIVDVDDEGGKAGDKVNIVNQIQCWGLGQWLADHAGLNNAFDAYATRSALCTGFMAYRDLPENEQDPEYADLIATLAELKRLRPFMDEERIGLIAPDLDKEALAAFQHHRHSDASGIIVALRGPEANADSVTLHPEYIDVGGTYQVTKWNDYRQLPATRISGAALKELAMTIAQRRSSVLVEYHRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLK7</accession>
    <name>A0A139SLK7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">AXK12_05220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068628719.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05220"/>
    <dbReference type="EnsemblBacteria" id="KXU35374">
        <property type="protein sequence ID" value="KXU35374"/>
        <property type="gene ID" value="AXK12_05220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="54" mass="6533" checksum="B7E702354A356189" modified="2016-05-11" version="1">MQDQIILECTEARKEGKPVSRYLSTRNKKTVTERIEKKKYNPHLKRHTLHKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS7</accession>
    <name>A0A139SLS7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35509">
        <property type="protein sequence ID" value="KXU35509"/>
        <property type="gene ID" value="AXK12_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="373" mass="39113" checksum="E284DAAF992342C5" modified="2016-05-11" version="1">MCATTMMTLVGGLLATRIAPSPKLATVPLAALVIGTATAAVPAALLLRRFGRKRGSLFGYALGLAGAGTGFLGTLTSGFYLLALAGLLLGMAAAFWQQFRFAALESVADQTQHGPALSLMLCGGLLAAFIGPEIGARGDEWFPALPSYAGSFLLLGLVTLGGLGVFQLYRETGGSTRRETATTRPLGEIVKTAAFIIPALGAAIGFGMMTFIMHATPITMHEVCGFDLGSTKRVIQGHIVAMYLPSLFSGGLIARFGVGRVMTAGAVLYIGVVTVGLFGQELVHFWGTLLLLGVGWNFLFMGGTALLPKSYAPAERFKVQAANDFMVFGAQAAASLSSGWFVFTLGWHGLLLGCLPILLVAVTLSLWQVRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLU2</accession>
    <name>A0A139SLU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">pyrG</name>
        <name evidence="13" type="ORF">AXK12_05170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000041">
        <property type="protein sequence ID" value="KXU35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711943.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05170"/>
    <dbReference type="EnsemblBacteria" id="KXU35454">
        <property type="protein sequence ID" value="KXU35454"/>
        <property type="gene ID" value="AXK12_05170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="301"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="381"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="558" mass="61400" checksum="3F683D24258ECB67" modified="2016-05-11" version="1">MKYIFVTGGVVSSLGKGLTAAALGALLELRGLTVRIQKFDPYLNVDPGTMSPFQHGEVYVLEDGAETDLDLGHYERFTSGKLSRLNSLSSGQVYESVIQKERRGDYLGKTVQVIPHVTNEIKERIYAGGRGDADVLITEIGGTTGDIEGLPFLEAMRQFALEVPPRDVLFIHVTLVPFLQAAGELKTKPTQQSVAKLREIGIQPHILVCRTDRALDSGLREKLSLFCNVPTKAVVECRDVEHSIYELPLALQREGMDELVVELFGLKRPPPAKNIWTQIVGRILNPAGEVTIGVVGKYIELQDAYKSIYESITHAGIANNCRVNTVRIDAEDLEKKGGLAALRKLDAILVPGGFGDRGTEGKIAAAKYARENGVPYFGICLGLQIAVIEFTRNVLKLREADSVEFNAETPHPVINLMEEQKQRVDKGATMRLGSYDCALTSGTLAARAYKAESVRERHRHRYEVNNAYLPQLRDAGLVISGINERRQLVEIVELKGHPWFLAVQFHPEFQSKPNQAHPLFAAFIAAAKKRKARANDAGDTSAKSETKLKSAVETAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLX3</accession>
    <name>A0A139SLX3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="8" type="ORF">AXK12_05100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711913.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05100"/>
    <dbReference type="EnsemblBacteria" id="KXU35500">
        <property type="protein sequence ID" value="KXU35500"/>
        <property type="gene ID" value="AXK12_05100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="364" mass="40245" checksum="4C1BDB390F4D09F5" modified="2016-05-11" version="1">MQSPLPDLAPFQQRHDELAAQMADPAFYNNPRAAADISREHQRLHELLGSHARYAKLLANIAEAEALKSDSRADPELRELALGELPTMQAEADALHAEILRAMIPPDPSDSRNTVMEIRAGTGGDEASLFAADLYRLYSRYAETRGWRVQVMSSSGSDRGGFKEVIFLISGSDVYKQLKYESGVHRVQRVPVTEANGRIHTSTVTVAVLPEAEEVDVQIDPEDLEITVSRASGPGGQGVNTTDSAVQILHKPTGLIVQCADERSQIKNKARAMTVLRSRLLQRREEEERAKYASERKSQIGSGDRSERIRTYNFPQNRVTDHRIGLTLQSLPQVLAGEIDELLTALQRADHAEKLAAINRGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM19</accession>
    <name>A0A139SM19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711869.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35608">
        <property type="protein sequence ID" value="KXU35608"/>
        <property type="gene ID" value="AXK12_04995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="15842" checksum="C46A02BE64FC147E" modified="2016-05-11" version="1">MTELHQQILGTWALVRAELGGAGSAQGAISGGEAMPPEIAARVEIEFDAESAYRVRFAGEISDAGHFEIFAQTESEAPPHHPITLHGKVGTNAGRTLPGICQLRGDRLRLCLALEGDAPPTGFASPPAANAAPYYLVTYRRKTRPSAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM21</accession>
    <name>A0A139SM21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ORF">AXK12_05045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711886.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05045"/>
    <dbReference type="EnsemblBacteria" id="KXU35616">
        <property type="protein sequence ID" value="KXU35616"/>
        <property type="gene ID" value="AXK12_05045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="346" mass="36296" checksum="3A2CAC24F88AEF3A" modified="2016-05-11" version="1">MKVGVVGASGYTGEVLVQLLLKHPAVDLAVVTSRAQAGKPLSAVIPALRGVDRGLRFVDSDAAALAASDCALFFLALPHGAAADYARAFVAAGKRVIDLSADFRVADLATYTRYYGAHHAPELLPQARYVLPEIAGERWRSEARLVAAPGCYPTSILVPLVPLLRAGLVSREHIVANSFSGVSGAGKKAAEMYLYVERAESAKAYGLTAHRHLAEIEEQLTLAAKAGGGGEPVVLQFNPHLAPMRRGIATTITVPAAAGATLSALRTAWEAAYGAAPFVQILAEGETPDTAHVVGTNRIDISATYDPRTRNFVLTSAEDNLMKGAGGQAVQIMNLWCGFAEAAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM44</accession>
    <name>A0A139SM44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711858.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04950"/>
    <dbReference type="EnsemblBacteria" id="KXU35601">
        <property type="protein sequence ID" value="KXU35601"/>
        <property type="gene ID" value="AXK12_04950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="206" mass="23969" checksum="81E48F74491D18BD" modified="2016-05-11" version="1">MDAVLDQPVLVLNRLWQAVNVIAARRAFAILARGHAQVVYNEDDDFRTFGLLEWIDFSASRPPRDEPLEIVHTPTRAIRLPRVILLSVFDRLPRKDVKLTRNNVFERDKNTCQYCAKVFPRAELNLDHVIPRDHGGRTTWENIVCSCIPCNSRKANRLPHQAGMRLIRKPVRPKWRPVISLVLGNRPHEAWKGFLDHAYWNVELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM75</accession>
    <name>A0A139SM75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711787.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04790"/>
    <dbReference type="EnsemblBacteria" id="KXU35686">
        <property type="protein sequence ID" value="KXU35686"/>
        <property type="gene ID" value="AXK12_04790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="680" mass="74291" checksum="DB46F6389C35F01B" modified="2016-05-11" version="1">MASLRFRQVHLDFHTSGAIPGIGEKFDKRAFQESLKLGRVNSITLFSKCHHGYSYHPTKVGVAHPHLKGDLLARQIEACREIDVRCPIYLSAGLDEVAAQAHPEWVVTRRDGTSAVPFKASWRLLSFNSPYLDYLCAQIEEVVTRWPDNDGIFLDIISAPLDYSNTSIAQMLAAGLDPESEADARDYAERVLYRYFERTTAAAQSVRPDTPVVHNSGDVSLGTVRAHGFNTHFELESLPTGGWGYDHFPLLARYVITQGKDFLGMTGKFHTTWGEFGGFKRAASLRYECAAMLAYGAKCSIGDQVHPSAQMNTDTYALIGEAYAEVEAKEPWCAAVRSVAKIAIVSSRQNQARWNADHTQGLAADEGAGRMLLELHQPFVVLDEHASWQPYEVVILPEGFVMTPAKAEQARAFIASGGRIVAAGSALLNEAGDAFALPPAAGVGLRGRSAYNPDYLVATEHAPRVPVRSPIVIHGGAYEVDLAKVSGDGARAAVSVLAERRVPYFNRTWGHFCSHQHTPDAPEQPGAGTSPAAIAGEAIAYFAHDLFSAYRRQGQPLYRDFFEAALRHLLGGVLPVETSGLPTSGRVNVLEQPGEGRYVAHLLYAPTSVRGTFNGKPIEIIEDLVPLRAVSVALRLPRVPRSLRLVPEGRALDFQVSDGGVVHFSVPEFTAHQMVELAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM89</accession>
    <name>A0A139SM89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_04900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711832.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04900"/>
    <dbReference type="EnsemblBacteria" id="KXU35655">
        <property type="protein sequence ID" value="KXU35655"/>
        <property type="gene ID" value="AXK12_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="9">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="8">
        <location>
            <begin position="115"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="287" mass="30904" checksum="D507D6971CE89118" modified="2016-05-11" version="1">MLSALSELSVAFPWFGWVAIFVFGACVGSFLNVVILRNPRGQSVLRPGSRCDGCAAPILWRDKLPILAWLFRRGRARCCDARFSFRYCAVELLTALLFLVCWLSFPPLKTLCAVAFLSLLIVASFIDQDHRIIPDWLTIGGAALGLFLSLCVPELHGFLSEPMGSESPVPLAHFRAFASSAAGLFIGSGLLLWIALVAEVFMKKEAMGFGDVKFVGMIGAFCGWQGAVFAIFGGAILGTLFVGALRLIGKRAPNGQIPFGPMLAAAATIYFFGGGTLTSFLGNFTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB7</accession>
    <name>A0A139SMB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">AXK12_04785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068628199.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04785"/>
    <dbReference type="EnsemblBacteria" id="KXU35685">
        <property type="protein sequence ID" value="KXU35685"/>
        <property type="gene ID" value="AXK12_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="45" mass="5214" checksum="567C2EA6B27C3CA4" modified="2016-05-11" version="1">MQPTFRPHRKKRARQIGFRARKATASGRKVLAARRAKGRKRLTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMG6</accession>
    <name>A0A139SMG6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="8" type="ORF">AXK12_04780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04780"/>
    <dbReference type="EnsemblBacteria" id="KXU35684">
        <property type="protein sequence ID" value="KXU35684"/>
        <property type="gene ID" value="AXK12_04780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="151" mass="17002" checksum="B076948C6041018E" modified="2016-05-11" version="1">MSVRQTSAAPRNPPAPVPRATRLLPEQHLRTQSDFQTVRQAGRRHQCDAFTAWWLACPKPASIRPDRPLTSRPQANASLRLGVVASRAAVGNAVQRNRAKRRLRALFRLHQQKLPPDGDLLLVARRLLNGLPWAVLETRFADLCRRLGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMX6</accession>
    <name>A0A139SMX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvA</name>
        <name evidence="13" type="ORF">AXK12_00050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711728.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00050"/>
    <dbReference type="EnsemblBacteria" id="KXU35842">
        <property type="protein sequence ID" value="KXU35842"/>
        <property type="gene ID" value="AXK12_00050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="422"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="502" mass="55385" checksum="6D75B10FDD6F2B01" modified="2016-05-11" version="1">MIDYLQKTLTARVYDVARQTPLEKAAHLSARLNNTLLLKREDMQSVFSFKLRGAYNKMAQLAPEALARGVVCASAGNHAQGVALAAKRLGARAVIVMPLTTPQVKVQAVRTRGAEVVLMGDSFDEADAHARALEKRQGLTFVHPFDDPDVIAGQGTVGLEILRQHQGPLDAVFVPVGGGGLIAGIAACLKRVRPEVKIIGVEPSDSAALAHSFKAGRRVRLEHAGLFADGVSVKQIGEETFRLCRRYVDDVILVESDDICAATKDVFEDTRAVLEPAGALAVAGAKAYVERERLRGATLVAVASGANLNFDRLRYVAERAEIGEHREAVFAVTIPEGPGNLKRFCKLVGKRSVTEFNYRIADEREAHIYAGIRVSGRDESEKIAAYFERHGFRTLDLTNDEMAKTHIRHLVGGRSPLAHDEVLYRFEFPERPGALMGFLTAMSPNWNISLFHYRNHGADYGRVLAGLQVPTKDKPALCRFLEKLGYRYWDETENPAYKLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN23</accession>
    <name>A0A139SN23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711696.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35968">
        <property type="protein sequence ID" value="KXU35968"/>
        <property type="gene ID" value="AXK12_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299283" evidence="1">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="16781" checksum="F93BED93FEB266F7" modified="2016-05-11" version="1">MNRCVPVFLLALIALLPLGLSGCATKPTAQRSAELNLAQFHRVYVETRLNDNHAIDAKIASELRRRGFTASHGHLSMMPEDTEVLIRYDARWTWDFRAYLIELHLAASTAKTHKPIATGQLRQLGLRPKPPEALITRLLDQFLKGNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN31</accession>
    <name>A0A139SN31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711716.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04665"/>
    <dbReference type="EnsemblBacteria" id="KXU35978">
        <property type="protein sequence ID" value="KXU35978"/>
        <property type="gene ID" value="AXK12_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299342" evidence="2">
        <location>
            <begin position="32"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="307" mass="33097" checksum="0375DD6B8CA1B5C5" modified="2016-05-11" version="1">MIPRLSFKRVSAAAALLALLAPLGLVPTAQAARSWIVPSQTVLSKATRWVSFEAARSNFLFNPNRGAIPVEQIGVTGPDGQPRELINAFNGRLRSGFELELTEPGTYRIEQIPAAPGAPQGRGGPPTPQGIRPAAAQAPAAPTYFGSYLGEDGQRVRWRGTLEELKAQDLASKPEFALSERGRSRLVTFVTLGEPNDTVLKPEGTGVELGFEQTHPNDVYVDEPATFRVLADGKPVANAKVTVVREGDRYRDEEGAIDLYSDSEGWVRIEWPGAGRYHVQAQASSQGTLHGVPSTKSSSYAVILEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN54</accession>
    <name>A0A139SN54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711698.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04615"/>
    <dbReference type="EnsemblBacteria" id="KXU35969">
        <property type="protein sequence ID" value="KXU35969"/>
        <property type="gene ID" value="AXK12_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="210" mass="22129" checksum="F930E46282092417" modified="2016-05-11" version="1">MRITGGKARGIPLVVPRGDAVRPATDALRQALFSSIGARVEGARFLDLFAGSGAYGLEALSRGAAAGLFVERDRRTLACLEKNLAAVAKSFGQHAEGEMRVKTAAKILAADVVSPSWDAAATALAPALVFIDPPYERIEAIADPLFARLRTLLAPQTRAESPQPAALSSALVIFEAPGGLKLAPEGWHCLKRLGGKKPQQPSLLLFELAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN56</accession>
    <name>A0A139SN56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711579.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04330"/>
    <dbReference type="EnsemblBacteria" id="KXU36053">
        <property type="protein sequence ID" value="KXU36053"/>
        <property type="gene ID" value="AXK12_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="299" mass="32477" checksum="43DB70775EA3567A" modified="2016-05-11" version="1">MANWLLIDGFNLAFRAFYGMPELTRSSDGFPTGALHGWVKALWRLIDEQRPAGGALVFFDLGGSQERLALHPEYKAQRRETPEALTQQLPFIRELTRAMGLGGIEREGVESDDLLAAQAVALAGGGDTVRIVSADKDFAQVVGGGVTLLLPPPTANPRIGWRHLDAVGVTEKFGVGPGQIADFLALVGDTSDNIPGLAGVGPKTAAKWLQAHGSLEGVLANAAEIKPERFRQELASAAERLRLNRQLTRFDLSLPTLTREELAQSQHINLGELLRLLGELEMKSAQAEAQRRYAQPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN88</accession>
    <name>A0A139SN88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36027">
        <property type="protein sequence ID" value="KXU36027"/>
        <property type="gene ID" value="AXK12_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="68" mass="7810" checksum="D3F31C5D9B243DA5" modified="2016-05-11" version="1">MIERSPKGQGIWLEARHSRVLRTLAGALSPYAWGAAVGCFIWRRARWPAVHSIWDFATRYRAKAKSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN95</accession>
    <name>A0A139SN95_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711546.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04225"/>
    <dbReference type="EnsemblBacteria" id="KXU36037">
        <property type="protein sequence ID" value="KXU36037"/>
        <property type="gene ID" value="AXK12_04225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="109" mass="12462" checksum="51AC2B596CA5DE52" modified="2016-05-11" version="1">MPSASRVEIADDLERVVRTLNQIVDWRGKPASIRCDNGPEYQSRAITEWANAKQIKLAYIQPRQPQQNAYIELLDRKSLRAFPVKTMPHFLGSSPMLEPNQKLETGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB5</accession>
    <name>A0A139SNB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711704.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04635"/>
    <dbReference type="EnsemblBacteria" id="KXU35972">
        <property type="protein sequence ID" value="KXU35972"/>
        <property type="gene ID" value="AXK12_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="34630" checksum="E2E038687C97613C" modified="2016-05-11" version="1">MNSVQHTARVGLLFLLGLALIWVTYEALGSKSALSKTGYPIVAGFQNLKALKQGDDVRMAGVRIGAVETTQLAGHRVEAILRIDKKVTIPSDARATITSSGLLGTNYVAITLGTPHAAPLGPESEIRTYESADLGTVMAQLGDLGEKLEDTLGAVSGAFRSQDGQPSLFERLNQLLSDNGNKIDAVMSNLESITNKVNRGEGTLGKLVNDPAVYDQLLATITEIKDAANEARGFVTGAQELVAHVKTGQGTLGTLLYDEKATADLKAMMANFAQVSEKLSKGEGTLGKLINDDTLYTDAQATLQKADRALGAMGDSGPITAVGAVANALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB9</accession>
    <name>A0A139SNB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711708.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04645"/>
    <dbReference type="EnsemblBacteria" id="KXU35974">
        <property type="protein sequence ID" value="KXU35974"/>
        <property type="gene ID" value="AXK12_04645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="522" mass="58944" checksum="591C9F4905708EAC" modified="2016-05-11" version="1">MNAKHFRNVIGVAVLCLAIVASFWRVTSRTVQPVPSDRIELRIGHPHLHSGMREGFAAAIESYQRLHPNVSITQVAVPQRLYPIWARVQLVGGTAVDILDAFNVPEPTRHFVSLTPWLDEPNAYNAGTSLEGVAWRDTFFDGLSSQLSLSEEIYAVMLQTVSHRLFINLDLLSEITGSQDDVPRDFDDLRRLAEQVRNYNQRTGKRIVPIASCRPYANVTFAKMLRSLTQKLVRDHSPSRTMSLPELDRLILDGTFSYSRTPEFIHSLELMSELSQMFTPGFLQFEHEDAIATYLRQHSLMIIAGTWDYGTLEKNAPFKTRGLPVPTPSPSDHHYGPFTLGQVAEVPMNAAELGIIRTSPNREAALDFLRYLSSQPVAAQFSRISQRLSAIIDTPIPKSLEQLRTTSEGAANGFRVDVLGANANTLINRHIHLVVGPQPDISKFAELIDAEIAPYIRQDLATQLRNSKREIRDLDTALALHLTFPENKALPRTTWTLYAEQQHKRQYDHLITRRYVPSYSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE5</accession>
    <name>A0A139SNE5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">AXK12_04580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711722.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04580"/>
    <dbReference type="EnsemblBacteria" id="KXU35981">
        <property type="protein sequence ID" value="KXU35981"/>
        <property type="gene ID" value="AXK12_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="158" mass="18157" checksum="0542F1C1D4322A9E" modified="2016-05-11" version="1">MRCPKCSSIEDKVIDSRISREGNTIRRRRECLECGHRFTTTEVLVRDGLIVIKRDGRREEFSREKLTAAIRAACHKRPIDIEQIDMIIDDTVDMLEARFDNALPSRALGEGIMQRLRALDQVAYVRFASVYKEFRDVSEFMDEISSLSKVAPAPLVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH7</accession>
    <name>A0A139SNH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711486.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04050"/>
    <dbReference type="EnsemblBacteria" id="KXU36011">
        <property type="protein sequence ID" value="KXU36011"/>
        <property type="gene ID" value="AXK12_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="412" mass="43954" checksum="EFDEC623ACC21AEF" modified="2016-05-11" version="1">MKHTRIVITGLGLTAPNGNSLAEFRANLLAGVAGIERMDIRYVGEQLAGVCHYDPLKYQRKKELRVGTRAGSIAIYCAQEAVVDSGVDFAAADKDRVGIYIGCTEHGNVETENEIYAISKFNYDTKYWSHYHNPRTVANNPAGEASLNLGVTGPAYTIGAACAAGNLGLIHAAQMLRLGEVDFAICGGVSESIHTFGIFAGFKSQNALASHADPHKASRPFDSARNGIVVSEGGALFTLERLEDAQARGAKIYGEIAGYHVNSDASDYVLPNPTRQAQCVRKAIAHAALTPADIHIVNTHATSTPLGDIQECEALRTVFGEGCPDTYFNNTKSYIGHCMGAAGALELAGNLPAFDDRIVHPTINVDALDPACALPNLVLNSPRQVVRVDTILNNSFGMLGINSALIVKRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH8</accession>
    <name>A0A139SNH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711540.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36034">
        <property type="protein sequence ID" value="KXU36034"/>
        <property type="gene ID" value="AXK12_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028963">
        <property type="entry name" value="Imm9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15587">
        <property type="entry name" value="Imm9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="160" mass="17788" checksum="398E2B9DC14CBAB8" modified="2016-05-11" version="1">MKPKQISALMSIKVPGLGNSADMDSIEKKINTYIESISPGISIEDLSGWRVTFDINSFCTDLIAIYKKFWGYPSDREYVISIAIPLPDNTQAPYGMPPGENGRSGSFPPVESDHFYPLAPEYDKYASLEQYIIVSAIKAIDFGLTKGFTCDGKEIKFQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNI0</accession>
    <name>A0A139SNI0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="ORF">AXK12_04315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711572.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04315"/>
    <dbReference type="EnsemblBacteria" id="KXU36050">
        <property type="protein sequence ID" value="KXU36050"/>
        <property type="gene ID" value="AXK12_04315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="46"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="211"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU36050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="32125" checksum="6CE71B08F0356596" modified="2016-05-11" version="1">MIGLPKGSLEEATKNLFHKAGWRITTSSRSYRPAIDDPELEGRFVRAQELSRYVEHGFFDCGLTGSDWICENESDVHEVCDLIYSRASSTRSKWVLCVPESSSITRPEELADKRVATELVGTVRRYFAERKIPTHVEFSWGATEVKVPDLVDAIVDITETGNSIRANKLRIIDTLLETNTKLIANKRSWENPTKRKKIETLALLLQAALEAETKVGLKLNIRKDALDKVLATIPALRNPTISPLSNPDWAALETIIDDRVVREIVPQLKSLGAEGIVEYPLNKVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNI9</accession>
    <name>A0A139SNI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04325"/>
    <dbReference type="EnsemblBacteria" id="KXU36052">
        <property type="protein sequence ID" value="KXU36052"/>
        <property type="gene ID" value="AXK12_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="348" mass="39526" checksum="3489F0428A9CD1B5" modified="2016-05-11" version="1">MGLTSEPISEHGFRMPSEWEPQDAVWLSWPHNRKTWPGQFRPIPYAFAQFVAAISRYESVRINCAQPLQPRAQRLCAKAGADMTRVHFYDHPTNDAWCRDHGPIFVKKRTTGEVAVTDWHYNAWGDKYPPYDLDNRIPALIAEKLGLRRFAYEMVLEGGSIDVNGRGLLLTTEQCLLHPNRNPQLNRAQIERRLIDALGVTQILWLGEGIVGDDTDGHIDDITRFYSAAGILTCIEPNTRDPNHEILEANLERLRGFRTPEGAPFDLVTLPMPRPLAFQGQRVPASYANFLIINGAVLVPQFRQPKRDAEAREIIGHCFPDREIVGIDCYDLIWGLGTLHCLSQQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ9</accession>
    <name>A0A139SNJ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711582.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04335"/>
    <dbReference type="EnsemblBacteria" id="KXU36054">
        <property type="protein sequence ID" value="KXU36054"/>
        <property type="gene ID" value="AXK12_04335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="718" mass="75933" checksum="C10776F9E3383B68" modified="2016-05-11" version="1">MLSKNTLLFGSLFVGLSSAPSGSPPLYAQQGSVGVGSSASAAPEPLVSDSSHSQSLGDAEVKTLLLRARSQYVAGAPEAALATYRELDQRSPGNRELAAAIDRLEQELEARRTPPRLQTRQEMLAEVDQSWRRPGLFQEQGRDPFDEAALAPLVRKLDEIVLPNVSFTRVEIGRVVSALSAASVEFDRSAQGAGEGEGTRAPRGANIVLLDPSNRQPLVTLTLRNTSLRRVLDFVTQAVGYQYEVQSDAVVVRPGGESSLLETGFFPVSRATVLRMTGQTLGNGAASTPSVSPSPFSSFGASNESPPTGQEAPALRHFLQQAGVNFDAVPDSSLAYDGSSIIVTHTARNLERIRNILNRYNDIRQVEIEAKFMEVQEGALEELGVNWNLNTKATQRNAGAQARYMTSGRNLSTAFASNVATQQGSITRPVTIGPSGEITAGIDTVFANSPPAIPNAPYLGVGASALASVTGVIGEFDVNAVIRALSQKQGTDLLSAPKVTVLSGNPATITVAQELRYPQSFGQTQSQVGTGSASGGGSAGVAITAGTPQDFTTRNIGVELKVTPTVEEDDYSISLDLNPRVTEFDGFVEYGGPSVAISGSTTVNVPSGFYQPIFSVRDISTKVTIWDGATLIMGGLTREEVKKVNDKVPVVGDIPVLGRLFKSKGESAQKRNLLIFVTANLLSPGGAPKKQALPNVSANALFQNPVIITPESSQSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR6</accession>
    <name>A0A139SNR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5 family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711306.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03545"/>
    <dbReference type="EnsemblBacteria" id="KXU36225">
        <property type="protein sequence ID" value="KXU36225"/>
        <property type="gene ID" value="AXK12_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="212" mass="23183" checksum="344CE535709AEE75" modified="2016-05-11" version="1">MSAPAESRFARAVTPVTLSGHGVRLAPLAGAHADGLRRAAADGALWHLRITSVPAPDQTEAWIAAALQGQARGHMLPFAVLDATSGEVLGSTRYHDIVPELARLEIGHTWYGQRWQRSHVNTACKLLLLRHAFDTLGARVVGWRTDNYNFASQRAIERLGAKKDGVLRGHAARRDGTIRDTVMYSMTAGEWPEAQAHLQYLLARHAGQARVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU5</accession>
    <name>A0A139SNU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711368.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03765"/>
    <dbReference type="EnsemblBacteria" id="KXU36259">
        <property type="protein sequence ID" value="KXU36259"/>
        <property type="gene ID" value="AXK12_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="129" mass="14132" checksum="CC6B46E8588D2078" modified="2016-05-11" version="1">MVTKLLHTRMRVNDLEATLRFYVEALGLTVTHRTTSPRGAKLGFLATPNSEELIEICQMPEGMAEPVVVQPDLVHLAFSVEDMAAFEAELKRRGYALSDGPTQTSSGSIIAFIDAPEGYEVELVQPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNV7</accession>
    <name>A0A139SNV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_03740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711363.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03740"/>
    <dbReference type="EnsemblBacteria" id="KXU36256">
        <property type="protein sequence ID" value="KXU36256"/>
        <property type="gene ID" value="AXK12_03740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="277" mass="30393" checksum="68665BD547CAA01E" modified="2016-05-11" version="1">MSHPNSTPTLTLNDGYQMPQLGFGTFELSDEAVVPAVLKALEVGYRHIDTAKAYHNEAGVGRAVRESGLPREEIFVTTKLWNTDHERAGEALEESLERLGLDYVDLYLIHWPKLGLDKRVEAWAAMEQARAKGLIRSIGLSNFTPQFLSEILKNGSVVPAANQVEYHPTFQQRETVAANAAAGVVTQAWSPLGQAKHLDNAVLGRIARETGRTVAQVVLRWHLQQGRVAIPKTATPARIAENFAVTDFSLTPEQMAAIDALHSGNRLGPDPDLVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ9</accession>
    <name>A0A139SNZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711435.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03925"/>
    <dbReference type="EnsemblBacteria" id="KXU36171">
        <property type="protein sequence ID" value="KXU36171"/>
        <property type="gene ID" value="AXK12_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299356" description="Thioredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="18855" checksum="D6144E408BBE1E14" modified="2016-05-11" version="1">MKLRSFLTAFVPFCSCLLPLSAAAAQPLAVGDTAPSVSALADNGESLDFAEVYANNRYTLVYFYPKAGTAGCTAQGCSLRDAYEELTERGVAVIGVSTDTVEAQRAFKEAQGYPFPLIADVDQKVISAFGVPMRAFGGSDFASRQAFLIENGKVIWADYKASTSKQAEDVLSVIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP25</accession>
    <name>A0A139SP25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Biotin carboxylase</fullName>
            <ecNumber evidence="3 9">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_03870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="3 9"/>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711415.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03870"/>
    <dbReference type="EnsemblBacteria" id="KXU36201">
        <property type="protein sequence ID" value="KXU36201"/>
        <property type="gene ID" value="AXK12_03870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="455" mass="50166" checksum="DC569361BFCEE7A8" modified="2016-05-11" version="1">MIQKILIANRGEIALRIVRACRELGIKTLAVYSEADVQSLHVQLADEAICIGGPRSSDSYLRTDRIISAAEIADVDAIHPGYGFLSENAKFAEQCESCNIKFIGPKSKTISMMGDKAVAKSTVLKAGVPTVPGSDGPVASETEAVKIARKIGYPVIIKAVAGGGGRGMRIAHNDVSFGKEYHSARNEAEKAFGNGDVYIEKYIANPRHIEFQILADSHGKTLHLGERDCSVQRRHQKLVEESPSPFLTPDLRKKMGKAAIRAATAAGYENAGTIEFLVDSKGKFYFIEMNTRIQVEHPVTEEVTGVDLIKEQIRIANGEKLDFDQSDIKFKRHAIECRINAEDPARNFIPSPGTIGLYYAPGGHGVRVDSHAYSGYQIPTHYDSMIGKLICYGRDRKTALERSYRALSEYIIRGIKTTIPLHKAIMSDPVFIEGKATTGYMEEFMNRMPPNLFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP49</accession>
    <name>A0A139SP49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711279.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36358">
        <property type="protein sequence ID" value="KXU36358"/>
        <property type="gene ID" value="AXK12_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="158" mass="16681" checksum="696B906F7C51C63F" modified="2016-05-11" version="1">MPVNEPTRPSGISALATTSGARVRAATSGAAQSDAVRDEFAAADARAIVRANDRLQGIAPEAYGDDDGAPIGPSEEEEAAFLAEDSSSHFSGGTSESSTRSLGTRLSARVEAEVISGPLPSLDELRERISPEILGLMDELFRAKLTRVVRVSERDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP51</accession>
    <name>A0A139SP51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711246.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03355"/>
    <dbReference type="EnsemblBacteria" id="KXU36337">
        <property type="protein sequence ID" value="KXU36337"/>
        <property type="gene ID" value="AXK12_03355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="5">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="108" mass="11778" checksum="F3E5CD6A398F7567" modified="2016-05-11" version="1">MTATENSEDSSHPGAAAPNLQLTKELVVQNKMGIHARPAAMIVRITNRYKSDVFVEKDSEQVNGKSIMGLMMLAAAKGSRVKFLANGPDAAQILSELEELFTRKFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP85</accession>
    <name>A0A139SP85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711268.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03450"/>
    <dbReference type="EnsemblBacteria" id="KXU36353">
        <property type="protein sequence ID" value="KXU36353"/>
        <property type="gene ID" value="AXK12_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="639" mass="71598" checksum="1F7D3DDF0D4CA85B" modified="2016-05-11" version="1">MAHPDQFWTSQDGQILHLKNGGDNRLSLVLAFWPRNPQEFAFLKEHLGQLRFSERSSLARIGIEMLLKGAPQLDGNRITLEAEAFLYDTSFPNAPYWTKLLRLGTPVGRLFYAPAPAKLSSTEIWEAIKANQIKLPSTTSIDSSGRVFFTPHAVSYTLDPRLQRLNFEHIVSGYAGRSFIDKVQVRRDAAPLAIPPRAGLLTSCSMYLKEHYVVLTTGEGNFGLHTSAVLLDPLKTFGTNIMLEVYNTGAQPVVNPMLSVEVFRAPPYADPEVKTLARHRQRLLSTTQGLFKCLDEFPASETHAPAPKTRITVRGQSATMENRSLFIRANDTELRKLLEGEACPLGSKTMIQALDAPTAAPDADTLVVDTFPDLLEHMELITRLGDIKLKRLIFRRASRTHGYFLSSNAHARLDTFHGLGIKVYWYDEVTRDIYLHTYKRDHGFFVREERARQFQESTILAFYGSAVGLDQRDTDRISALVDALTGFLGGNLGVLTGGGGGVMRLATEQAREKGAMTGACFLELEAQPPELGVDFFNTFQETSRHFRQKWFEAADFCIFNVGGVGTLEEIGIELCNLKLGIRPRVPYVFFNAGFWGDLRAQIEKMITDGRAPSWMADYVLFTDDPAEVVSFYRKKLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD4</accession>
    <name>A0A139SPD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">AXK12_03340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711242.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03340"/>
    <dbReference type="EnsemblBacteria" id="KXU36417">
        <property type="protein sequence ID" value="KXU36417"/>
        <property type="gene ID" value="AXK12_03340"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="390" mass="41869" checksum="00D0E7C91844F324" modified="2016-05-11" version="1">MSTPKPGVLALEDGSVFRGLAYGAAKTITGECVFNTSMTGYQEILTDPSYCGQIITMTAPQIGNYGLNAEDNEAGGPKCSGLVVRELSPVVSNWRATTSLPDYLTAHGIPCLSEIDTRALTKKLRVEGAMRSCLSTLPLSDAEAVALARSAAEMQGSDYVREVTCREPYLWRDDASENHNAPYLPAGTTLGTTTAPATRYRVAAFDFGAKHSIYRKLVRHGFEVQIFPATAPAALIREHAPDCLFLSNGPGDPAALPYIHKTVTELLGEFPTFGICLGHQMLTYALGGHTFKLKFGHRGGNLPVKNLETGKVSITAQNHGFATEPKSIEAGGGIVTEVNLNDGTVEGLRHRELPIFSVQYHPEAAPGPNDADPLFGDFYTLVSKRKAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPK3</accession>
    <name>A0A139SPK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000023">
        <property type="protein sequence ID" value="KXU36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711212.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00030"/>
    <dbReference type="EnsemblBacteria" id="KXU36508">
        <property type="protein sequence ID" value="KXU36508"/>
        <property type="gene ID" value="AXK12_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="40357" checksum="26D968960570BE4F" modified="2016-05-11" version="1">MPRRLNQAALAKQLNLSRATISRSLADHPAISLETRQRVRELAAELGYSPSPGRLRQRDPRAGKSNGQNRTGPGRRAASTLTVGALIGIPKHPTSMTVYSQIVSGLRARAVTERVSLDLCYQPPEELDVERIRQGAMRQIRANAWRGALLIHPFPSATVTALKRCLPLVSLLERYAQPEVDIIDVDDAPAISQLVHRLATAGHRRIGFVSWTYPVAGGWVARRFSGYVEALFSLGLEFRPKWVFNVHQAAASLSPTAVSTAVARLIEKDQVSAWVCAADHQAYGLISDLHARGLRVPRDCSVTGFDGLPPPESLTPAERLPRVTSMAVPHEQIGAAALTRLVNRIANPSAPYKKTLVDPQLIEGETLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPM0</accession>
    <name>A0A139SPM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000025">
        <property type="protein sequence ID" value="KXU36454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03295"/>
    <dbReference type="EnsemblBacteria" id="KXU36454">
        <property type="protein sequence ID" value="KXU36454"/>
        <property type="gene ID" value="AXK12_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="587" mass="66182" checksum="2179631F5DB4E55A" modified="2016-05-11" version="1">MRLLLLALAVCALWLTIEDRWGNNFLVPTRYIGDSHYILAMMKLAKEGDLGLFTHITTESLGAPFIGQLNDFPEAERAIVWLGGQIARVIGLMPAANAMLILSCIVAAFSFYFAARLWKISRLSAWGFALVYAFSPHNLRSLDSLGIIFTGLLPLQFYCLWYIATVEKVSWGSFRFRLTLVMGLLSGLLNIYWVFFFLNLYALALLCRIFKGRKNFIASLAPIVATCLMVGALLGSFIVYKLSYGENPAALVRSYWGIDRAALKPIELFIPSWGTYLEMFSGFFSRYYDGGKLGTGEEWWGTYIGLLPMAGLLLLFFKGIQRQVNKRAPSLPFLAACWVIAYASFGGINAIFSLILDFYDIRATSRYFVGIATIGLIYFVFVINRLMRNWSFATKFSVLGGLALLAIMDQSFHSYFYPRYNKPTHVMKELVMADRDLALRLEDNLEAGAMIYILPVLDFPEPLEGRGAYKINFFIYDPIRPFLYSTKLRYSYGSNKGRQGADWQLDVQDLPPREMAATLESYGFSGILFNRKDCADRGAQLLAELGEAGWPAEFEQGVNNEWVFIRLSPAANPVLPTLTPYALASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPZ2</accession>
    <name>A0A139SPZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711200.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36613">
        <property type="protein sequence ID" value="KXU36613"/>
        <property type="gene ID" value="AXK12_03125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="993" mass="109045" checksum="1BBEEB9852924754" modified="2016-05-11" version="1">MHTLRFAAWFLRAVSSLVAAAFGGRRARSFASLSLAGVLAALLVSAPLALAQSNVTGSLSGRVAPSASVTAVNVETGYSRTTTATSSGSFRITAVPTGRYRVSVEGEGEVLVEVFIGTTSNVSIGSDSIVELERLEVSGLSASFSPIDFGRTESVSIFGASQLEALPVARNTSAIALLAPGAVQGDTAFGNLISFGGASVAENAYFVDGFNLSDFRTGTNPIELPYEAYEQFEIKSGGYSAEFGRSLGGVINATTKTGTNTYKAGANVFYMPDSSLNGKNPDRYYTNQAGTPNTLWSYNGADKRERLEANIWASGPLIKDKLFFYALYNANEIKNEDVRAGGSRIRRQKQDDPLYFAKLTANPFPGHTLEFTFIETEKETLNTDTDYDFATKTDLGTDPTTITSKLGGDVKIARYVGSLSDRLTVSALWGKSKNDLSTFGSTDAEPLVLDARFGPAQRLSGTQAVVEPGSLDEREAIRLDVTYGFSLFGEHQLRVGFDREDNYSNVVTGYSGGGWFHRYATVTPGATLGGGIVPAGVTQVTRDRFLENAGSFQVTSDAYYIEDNWTTLDGRLLFRLGVRSENFENFNAAGESFVEMTQQIAPRLGVAYDLFGDQKTKIYANYGRYHIPVASNTNARLAGGEKFTEEWYELLGVNADGTPIRGRQIGTLQLLSPGTIPNKDSIVDRNLDPMYQDEFIVGIDHALSKDYRVGLRGTYRDLKSTMDDMIIDHALTDYAQNVLGLAGADFIGYQHYVLANPGKSITTLWDFEDGNGEQLVTLTPEQLGFTEGKRKYAAIELLFERIWDGKWAAQFSYTWSQNYGNTEGWVFSDIGQDDAGLTQQFDTPDLQRNSFGWLPNDRRHAFKLFGTYALTSELTLGANFRLTSGRPLNYMGWYDDSVTGTGYGEDYYLKQRGHAGRLDWVFNQDLSLRYVPKWAGRRLALQIDVTNLLNKQTVIQRDEVAEIDNTGTPRAEYLLPTAWQTPRRVTFSASYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ96</accession>
    <name>A0A139SQ96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02820"/>
    <dbReference type="EnsemblBacteria" id="KXU36707">
        <property type="protein sequence ID" value="KXU36707"/>
        <property type="gene ID" value="AXK12_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="22830" checksum="F339C56D0BD135B7" modified="2016-05-11" version="1">MKAPTPENDVPPASGAPNKTASGRVLFGLSGSIAAYKACTVISRLVQAGVSVQCVATPAALRFIGRATLEGLSARPVYSELWENGRALDHIALAREADLALLCPATANTLNRLAAGLADDCLGTLFLAWQREKPWWIAPAMNPHMWTHPATTAAIEKLKSWGAHILEPVDGLHACGDTGIGRLMEPEQIASEVLAKLEIASLNPQGGRRPDEGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD0</accession>
    <name>A0A139SQD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdh</name>
        <name evidence="9" type="ORF">AXK12_03035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711178.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03035"/>
    <dbReference type="EnsemblBacteria" id="KXU36743">
        <property type="protein sequence ID" value="KXU36743"/>
        <property type="gene ID" value="AXK12_03035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="8">
        <location>
            <begin position="162"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="14"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="331" mass="35110" checksum="3C601C5D7847DC29" modified="2016-05-11" version="1">MTQTKTPLRVAVTGAAGQISYSLLFRIASGAMFGPEQPVILQLLEIPNEKAMKALEGVAMELDDCAFPLLRGLVLSDDPRVAFKDANWSLLVGAKPRGPGMERADLLKDNGKIFTVQGQIIDEVAAEDARVAVVGNPANTNCMIAASKARRLTPDRFTAMVRLDQNRAQAQLAKKAGVALTEVQSIFIYGNHSPTMFPAFAQATIGGKAAREVIGDDAWLQGEFCETVGKRGAAIIAARGLSSAASAANALVDHVHDLMTPGAIHSVAVKGATHYGFDANVWAGVPVRTTTPGSYEIIEGYAMDDFAKSKIAATNKELTDERAMVAELLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQJ6</accession>
    <name>A0A139SQJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Addiction module antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711123.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36885">
        <property type="protein sequence ID" value="KXU36885"/>
        <property type="gene ID" value="AXK12_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="93" mass="10670" checksum="E7E4C819C4AFF4B6" modified="2016-05-11" version="1">MRTIEPTGQFRRDFKREKKGPHRATLDADLAGVLDLLAADLPLEPRHRDHALTGDWKDHRDCHIKPDLVLIYQKPDADTLRLVRLGSHSELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQV0</accession>
    <name>A0A139SQV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711091.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02540"/>
    <dbReference type="EnsemblBacteria" id="KXU36913">
        <property type="protein sequence ID" value="KXU36913"/>
        <property type="gene ID" value="AXK12_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009325">
        <property type="entry name" value="DUF983"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06170">
        <property type="entry name" value="DUF983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="15112" checksum="550D158CD79A4559" modified="2016-05-11" version="1">MKVSRQQILIRGLTNRCPNCGGKTLFKKGSLFEMNKACPVCGMRIEREEGFFLGALTLSYAVTLFCYMLPLAILSHSGRVGWTATIVLAGLGAIGIPILLYRPSRSWWLGFYYFFLPTHLPANQRPLAQGEDEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR46</accession>
    <name>A0A139SR46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711061.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02380"/>
    <dbReference type="EnsemblBacteria" id="KXU37013">
        <property type="protein sequence ID" value="KXU37013"/>
        <property type="gene ID" value="AXK12_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="181" mass="19340" checksum="5E9909316020DC23" modified="2016-05-11" version="1">MSARLRAFTVVEVLTAIAILAILTSVAVGGGAWAFRRAYTARAQAELSALATALEAYKRQHGDYPRTSGGESRGAQLLQALVGARGPSGAVLNPRGRLWIELGLFTTREGLDPLANAAADLIDPWGNAYVYIYKEPLGGWVNPGFVLYSAGPDGRHNPALLLGGYSQRDLDENRDNLYAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR51</accession>
    <name>A0A139SR51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711039.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37085">
        <property type="protein sequence ID" value="KXU37085"/>
        <property type="gene ID" value="AXK12_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="383" mass="39569" checksum="6D6A39213AE66C9C" modified="2016-05-11" version="1">MSLCAFVLIASEFMPVSLLTPIAADLRVSEGQAGWGIGISGVFAVLTSLVVPRLAGTRDRRTLLLALTAIMGASGAIIAFAPNYPVYMLGRALIGVVVGGFWSLSVAVAMRLVPLDQVPRALAVFNGGNALATVLAAPLGSYLGALIGWRGVFLSLVPLAAATIVWQRLSLPKLPALGGEESGTQERGTSVFSVFVSQRVVTLGMLAVGLFFMGQFTLFTYVRPFLENVTGVNDASTLSLILFILGAAGVVGNALIGAVLRRSLYGTLITTALLMALLALGLLGLGQHLACVAVLLALWGMIGTAAPVGWWSWLAQTLPKNAETGGALMVAVIQLAIGSGSFIGGLLFDGFGYRATFATAAALLLAASALAALTHRETRVGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR70</accession>
    <name>A0A139SR70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02490"/>
    <dbReference type="EnsemblBacteria" id="KXU37032">
        <property type="protein sequence ID" value="KXU37032"/>
        <property type="gene ID" value="AXK12_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="5">
        <location>
            <begin position="177"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="523" mass="55687" checksum="D5F3052ED37989E6" modified="2016-05-11" version="1">MAFVGSLCGVLLAVGVLRVATAFGWLDGRELQASADYLREVIGLVNTHYVDGQGVAASPEGLAREAIRTLVGSLDPHSEFLEAEHFKRFEEELDGDFGGIGVQVELRGGRLVVIAPIGGTPGERAGLRRGDEILRVDGHEIGRTASSGVSTMDDALKRLRGKPKTPVRLSIWRPGTEEELELEIVRDRIEVDSVREARLLPSRVAAGASEARGDLWASGGLEVGPIGYIQLVDFSARTGEQFLAALDRLIGGGAEALVIDLRNNPGGLLEAAVAVVEPFFKEGELVVYTQGREERASSGGAESSRTRGGERAKSGRGSAARTTRQEWRAAMVGEPVELPIAVLINSGTASAAEIVTGALKDTGRAVVVGERSFGKGSVQTLFKLRDGSGLRITTSRYYTPSGVSIHGHGIEPDVALVMSPEEDDKLRLQRARSDALEDLEEFEARFGFRPIADKQLDAAVDALRGVQLLRVRGFARALHRERLGEVGATEAQAQTDSLSALLGEGEATTGEESGGVKEAVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR79</accession>
    <name>A0A139SR79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02385"/>
    <dbReference type="EnsemblBacteria" id="KXU37014">
        <property type="protein sequence ID" value="KXU37014"/>
        <property type="gene ID" value="AXK12_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="208" mass="21674" checksum="B8FC166F417E86EB" modified="2016-05-11" version="1">MASVATAGFTLIEVLVVVAIIGVLTGILIAAASGVRDSASKARVKLQFAQWASAIEAFRSEYGQYPQLGASNKINGGDQGGSGGGEHLFHDILAGRRRDGQPLGPLAAAQNRRHIRFYTFAQSEFSESGGGSVLIQDALGNTDIAVLLDRNLDGRIDAADYPALPVVSREGVLIGAPLLPQGGLTISVAFYSAGAHATIANPEFIVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRE4</accession>
    <name>A0A139SRE4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711069.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02430"/>
    <dbReference type="EnsemblBacteria" id="KXU37021">
        <property type="protein sequence ID" value="KXU37021"/>
        <property type="gene ID" value="AXK12_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="82" mass="9594" checksum="9B12917CDDCB6135" modified="2016-05-11" version="1">MKSEIHPTLNKVCFLDVATGRRFLTKSTMRSARKEQIDGEEYFIVVRDVTMDSHPAYTGEKRLVDTAGRVEKFTNKFKRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRF3</accession>
    <name>A0A139SRF3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711078.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37031">
        <property type="protein sequence ID" value="KXU37031"/>
        <property type="gene ID" value="AXK12_02480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="147" mass="16081" checksum="A93C18E69023CBB9" modified="2016-05-11" version="1">MASFVPLISSGTVGPLGVAHLPRLWLKISLDSRGKLDSRYPAVGQGYDQMTIDALGLQKDAVVNFIKTQRPTYPQFEAWIKVQPGVKLDAATIEKHNAGVRGYTHDDETRKGILSANGLVDGPDVPKDAVTLNDLDGWQEFHDAELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS44</accession>
    <name>A0A139SS44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF374 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710992.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02070"/>
    <dbReference type="EnsemblBacteria" id="KXU37406">
        <property type="protein sequence ID" value="KXU37406"/>
        <property type="gene ID" value="AXK12_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07983">
        <property type="entry name" value="LPLAT_DUF374-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007172">
        <property type="entry name" value="DUF374"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04028">
        <property type="entry name" value="DUF374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF374" evidence="1">
        <location>
            <begin position="81"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="227" mass="25539" checksum="C05F4B4CA294FE99" modified="2016-05-11" version="1">MRGAPKEEPAAAEPEFKPYEIRGWRRALLWPLGALVRLWGRTLRFETSEADLCNLRKIDEPVAFVLWHNRLFVTPEVWRRYRQGRPLYALVSASQDGAWLTAFFSLVGLSAVRGSSSRLGREAASALVGVLRAGHDVGITPDGPRGPRYTLKPGALIVARRTQTPLLLLGAEFHSSWQLKRAWDRFYLPKPFSRVRLHCELVAAAELSARDAAAAQLETRLREMSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS85</accession>
    <name>A0A139SS85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710978.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01980"/>
    <dbReference type="EnsemblBacteria" id="KXU37392">
        <property type="protein sequence ID" value="KXU37392"/>
        <property type="gene ID" value="AXK12_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="63"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="498" mass="51354" checksum="E429F1E4920D839D" modified="2016-05-11" version="1">MSRLYFGTDGVRGPVGGALVNPSFFARLSVAACEWAKRTKCAAQREPASPRHDASAAEESRFPLRVLIGRDTRASGLELEQGVVAGILAAGGDPVLLGVLPTPAVARAVKTSGAALGVVITASHNPASDNGIKFFTALGTKLTDADEAEIEALLPESVPMPEPVEVAEVATDTSALEGYVTGHTALLPPQSLAGWRIAVDTANGATVGATPAVLRALGAEVVGLGDAPDGHNINAGLGSEHPEQLAALVCESGARLGVVHDGDGDRCILVDEFGAVLDGDEILTLLALDALRRSALAQRTLVITVQSNLGVDVALGAAGGRVLRTNVGDRYVSECMRAEAAMLGGESSGHIICADVSPTGDGLVTALRVIDVMRRTGEPLSSLRKALKKFPQKTSALSVRERRDLAGCPQLQAAIQKWESRFGRNGDAAAGPVCDRDNAPNKTAADGSRDCGLAVGRVMVRYSGTELKLRFLVEAADEATASEALSALEAAASADGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSV4</accession>
    <name>A0A139SSV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710910.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01615"/>
    <dbReference type="EnsemblBacteria" id="KXU37658">
        <property type="protein sequence ID" value="KXU37658"/>
        <property type="gene ID" value="AXK12_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="314" mass="35602" checksum="E22DF23D5D40C924" modified="2016-05-11" version="1">MPSTTPAAPRRKQAIVEQLRNSRIYRDYERAFRDMTGLPIALSGQGLGEYAPPHRGDPNENPFCALMARSNRTCATCLQMQRRMEDEAQLEPTTLRCFAGLCDSAVPVRVGENLVAFLQTGQILLHEPTKQEFSRSSQRLLKLGSDIDVRRLEETYFQTRVLDKQQYEAVLRLLEVFAQHLAMLSTELMVKAEEPEVSPAVSKACDFISTRHNEELSLPQVAKAVNMSSFYFCKMFKRSTGLTFTDYLARVRVQKVKNLLLNPHKRVSEAAFECGFQSLSQFNRVFKKITGESPKRYRARLTEESGRAAPATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSW5</accession>
    <name>A0A139SSW5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="5" type="ORF">AXK12_01625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710911.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01625"/>
    <dbReference type="EnsemblBacteria" id="KXU37659">
        <property type="protein sequence ID" value="KXU37659"/>
        <property type="gene ID" value="AXK12_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="83" mass="9292" checksum="AE9713D7B58E5E26" modified="2016-05-11" version="1">MDDTKQPDPSFETALQNLEQVIAVMEGGKVPLGELVAQFEEGSRLLKLCQNRLKDAELKVEQLRQASEAESAKFEPFEIGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC6</accession>
    <name>A0A139STC6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 9">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_01295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="9">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 9"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710852.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01295"/>
    <dbReference type="EnsemblBacteria" id="KXU37826">
        <property type="protein sequence ID" value="KXU37826"/>
        <property type="gene ID" value="AXK12_01295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="399" mass="41932" checksum="A871E006E6738FDE" modified="2016-05-11" version="1">MSLAVKIPNLGESITTGLLVKWHVADGDIVQKDQPLYELETDKITAEGTAEVSGKIALKVTEGTEVKIGETVAEIDEKAASASSPATSTGAPAAAPTSASPNKKDESPAVRRLAAESGIDPASVTGTGKAGRVTKADMLAAASAPKAVAPQPSKSAAPAPAARPVEKAKTSRKKLSSLRARIAERLVQAQHEAAMLTTFNEVDMSAVMALRQKYQDSFVKKHGIKLGFMSFFAKAVVHALQEVPAINARIEGDTLVENHYYDLGVAVSTPKGLMVPVIRDCDSLGMADIEQQIAAAATKARDGKITLADLEGGVFTITNGGIFGSMLSTPILNAPQSAILGLHAINERPVAIDGQVVIRPMMYLALSYDHRVVDGREAVTFLVKVKQAIEDPARLLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD8</accession>
    <name>A0A139STD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710861.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01370"/>
    <dbReference type="EnsemblBacteria" id="KXU37836">
        <property type="protein sequence ID" value="KXU37836"/>
        <property type="gene ID" value="AXK12_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="13872" checksum="1CEBFB086F97938D" modified="2016-05-11" version="1">MSLKLYTYAKCSTCRNAVKWLRERGIVFTEHAIRETAPSPAELRTMLAAYGGPSELRRIFNTSGMDYRAQGLAQKLPEMSVDEALALLGQNGNLVKRPFLIGEHEGRCVALVGFRQAEWAAQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN1</accession>
    <name>A0A139STN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710818.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01105"/>
    <dbReference type="EnsemblBacteria" id="KXU37791">
        <property type="protein sequence ID" value="KXU37791"/>
        <property type="gene ID" value="AXK12_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="579" mass="63508" checksum="2848FB5CEC3A65D0" modified="2016-05-11" version="1">MSPATPAPAAPTNSREITYVIGHKNPDADAICAAIAYTAFKEQRGEPNFVAARCGNSNVRIDTILHRFNQPLPLYLSDVFPRVHDLMTSDVVHISDDATCFEALEVFERRGVSVLPITDKDRKILGSLSLAQMGGFFVPHTQDPRRMREVHTSLSRIVRSLSATILTATDIDRLETLYVHIAAMDIASFWKMSERENIPASQSITIVGDRKNVQLRAIEIGSRALIVSGGRAVDPEVVALATERGTCILSSPHDTATTAWIVRTASTLERIIDRDFKTLSADLPLTLARKQFSPHSSHALLVADANGTLQGILTKSDLLRPVGKRLVLVDHNEMTQAVPGADQARIVEIIDHHRLGPINTQQPILFINEPVGSTCTIVADLYRREGLTPTPDLAGIMMSGLITDTLLLKGPTATAKDAEILRWLSGIAAVDPNQLADQIFSSGSVILGNPAKQVVRADFKIYTEEGVRFSVSQVEELGFRNFWKHATAIEQALQDLRDTEALAFACLLVTDINTQNSVLLVKGDPSVISRITYPHVKNEESFELPGIVSRKKQLIPYLGSLLREMADDDELPANPAPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP6</accession>
    <name>A0A139STP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710764.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37935">
        <property type="protein sequence ID" value="KXU37935"/>
        <property type="gene ID" value="AXK12_00805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="182" mass="20898" checksum="3A6FCCFE06A23D41" modified="2016-05-11" version="1">MKKWLYLIVPTVMLVVFTFFYLSQSKELEQQEIARKERVERERKEEEAKRAVIEEKARQDAAARAAEREAEAAQKEADRIAKWEAEGRDIQDATDAFNAEADRISKDISAKEIQLDTLRKQKEQLNTDVLNAAKRVELAQIAKRNAELEIQRKAELMLRRVESSAVAQMPAAQQAGSGTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP9</accession>
    <name>A0A139STP9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710783.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00930"/>
    <dbReference type="EnsemblBacteria" id="KXU37953">
        <property type="protein sequence ID" value="KXU37953"/>
        <property type="gene ID" value="AXK12_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="553" mass="60117" checksum="4029965BD4D3D981" modified="2016-05-11" version="1">MLQSLRIQNLALLEEVELDFEAGFTAVTGETGAGKSILIGALSLLAGQRADKTMIRQGAEALVVEASLFFADSERVDAVLMELELPICEEGVLILRRSLPREKAPKITINGSLATLSALQQLGELWIDFHGPSEPRRLLKESCQLELLDLYGRCGPALETYQRRYRAWREAEAAVERLQAQRRASPEQLEFLQSQLARMEALDLSEEAIGALERDFTRMSQVQELTELAGRLVEGLSGEEGVESRLAAVLADARRLREMDSESATLAERLSSAAIELADVASEASALLEGLQFDPQEAQQVQDNMSAWLDLKRRHGGDLDAVIAARGEMQRQLDEQGDIEGALLRAETARDAALREAQAAAAVLRVQREKAATGLGEVAAGAIAQLGFAKSEFRICIVPKELGPQGDCGVEFLFSPNVGEAALPLNRVASSGELARVMLALKTLLADLDRVPLLVFDEIDANVGGEIGAIVGQKLAQIAQTHQVLCLTHFPQVAAQARRHLLVEKDQTQSRAVVRIRGIEGEREARLGELARMLGDRNAASALAHAQRLLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STR3</accession>
    <name>A0A139STR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00945"/>
    <dbReference type="EnsemblBacteria" id="KXU37955">
        <property type="protein sequence ID" value="KXU37955"/>
        <property type="gene ID" value="AXK12_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="224" mass="23946" checksum="044A46E8D5758594" modified="2016-05-11" version="1">MRFVRASLFASTGLLLFFSGCREAKVQSYRVPKEAPLPPLSFEMPGGMAAANAGAGPNANPTAQPAIPAASAADAALRWTAPESWAPLPPVAMRVAGYRLTRADDSSTAELTITAFPGDVGGDLANINRWRGQIGLNPISADTLATELQRLRIDGPEGQEGERKPRDFKLVEMTNAQSSPAQATLAAYTEHDGHTWFFKLTGAPALISAEKPAFLEFLKTIQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STR4</accession>
    <name>A0A139STR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">AXK12_01000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710797.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01000"/>
    <dbReference type="EnsemblBacteria" id="KXU37966">
        <property type="protein sequence ID" value="KXU37966"/>
        <property type="gene ID" value="AXK12_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="231"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="614"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="726"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="648"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="879" mass="98620" checksum="A35756CBB5654A71" modified="2016-05-11" version="1">MSRCKEYDFRQIETKWQSFWEQNRTFRANEVANDGAADAAKPKYYVLDMFPYPSGAGLHLGHCENYAITDILARFKRAQGFNVLYPIGWDAFGLPTENYAVKTGRHPADVTRENVATFKRQLRSIGVSYDFDREINTTDPHYFKWTQWIWLKLFERGLAYVEDKPVWWCPALGTVLANEEVIDGKSEVGSHPVERRPLRQWVLRITAYADRLLAGLKDLDWPDSTKRMQAAWIGRSEGTEVEFDIEGVAPDEARLKIFTTRVDTLYGATYMVIAPEHPLAARLTTPEQRDAVAAYTRAAASKSDLERAELSKEKTGVFTGSYAINPANGKHVPIWVADYVLASYGTGAIMAVPAHDERDYAFAKKFGLPVVQVIARKNAIEATAADGDADALPFCESGDGLHLINSDDCNGLTPAEATAALQNRFAAEGRGKATAQYKLRDWLFSRQRYWGEPFPIVWVSKTDYAAALATAKTANLPLPPEPVTATFDGEERYALPLPASALPLELPKVQGYEPTGTGESPLAAVTEWLEIWHEPQTGKSVPASEPRPAPHWVRARRETNTMPQWAGSCWYYLRYLDPQNADALASPEALRYWSTPDLYVGGAEHAVLHLLYARFWHKVLYDLGLFPTDEPFTRLFHQGLILGEDGEKMSKSRGNVANPDDIIAHYGADTLRLYLMFLGPLEAMKPWSPRGIEGVYRFLQKIWRECLDGEGRPSAKLNDSQPDNEAFLRVLHETIRKVGDDIAALRYNTAISQMMICANALQKAPHVRRASIKLFLQVLAPFAPHFCEELWERLGESSGSLATAPWPAYDPQWLERDECKLVFQVNGKHRGDALVPKSIGQEDAVALAKAHPKVASQLEGKTIRRIIFVPQKIINLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STS9</accession>
    <name>A0A139STS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythromycin biosynthesis sensory transduction protein eryC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710870.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01155"/>
    <dbReference type="EnsemblBacteria" id="KXU37841">
        <property type="protein sequence ID" value="KXU37841"/>
        <property type="gene ID" value="AXK12_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="40406" checksum="27D7281DF5ABD03C" modified="2016-05-11" version="1">MKVPFLDLSLQHQAIRTEALAALAATYDATRFCLGQDVDDFERGFSQTLGYPAALGLNSGTAPLHMACLMAGFGPGDEVITTPFTFISSAWGISYTGARPVFADIEPETYNLDPAKLEAAITPRTKGIVVVHLFGLPARMDEIMAVARKHGLFVIEDCAQAVGAQYRGTPVGLLGDVGTFSFYPTKNLGACGEAGMLVARDEKRFARARLMRVHGSPRRYAHEILGGNWRMDGFQAAVLNIKLPRLRQWTARRREIARHYAAGIRLREAALPTIAADYGESVLHQFTLTHPQRDALREHLTACGVGTDLIYPLPLHLQKCYADLGYAKGSFPVAEQVAEQCLSLPIFPELTDAQVEHVIASVNAFNPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU11</accession>
    <name>A0A139SU11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38066">
        <property type="protein sequence ID" value="KXU38066"/>
        <property type="gene ID" value="AXK12_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU38066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="73" mass="8270" checksum="5767A66D4D4A094D" modified="2016-05-11" version="1">MRRGAEAAATQRATLKIHMPKSAQNLREKMRNPPPLFPPRPVSPTARGAAVSDRFHLIWDFSSRYRAKAKSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU42</accession>
    <name>A0A139SU42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="13" type="ORF">AXK12_01080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710811.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01080"/>
    <dbReference type="EnsemblBacteria" id="KXU37980">
        <property type="protein sequence ID" value="KXU37980"/>
        <property type="gene ID" value="AXK12_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="156"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="271"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="452" mass="49797" checksum="A11F20E8786A9E2E" modified="2016-05-11" version="1">MNVQLNSLSDTRKSLVVTLSSEEVSTERKAVVAEFVRQVRLPGFRPGKAPASLVERKFAKEIAGELQQKVVSRAYKEGHEKEKLDVLTLVNVEPGEIKVGAEASVTLTVDVVPQFELPTYTGLEVKVPAVEISDDEVEQILNSLRADRAEFKTTERAAQKGDYVKLAYEGTVEGQAIVELVPEKQIYGKVPQTWVEVESEEDGIIPGLGNEIAGLKPGDKKTVAVSFPAEFPAAPALAGKAASYAIEVQEIRERILPEIDEEFLKAHRADTLDGLKTDIANNLKLAKERDVHGAKRAQVMDAIAKAVSFEVPESLVESETQQVLRRVIGENMRQGVPEDVFEKNKEELYAKAREQATQRAKLQLVCERIAETEQVKVENEDMQNYVLNHAMRTQQSPDKVVQELSKDREAVRALQRSILFDKAVDFVVSKASVTVLSAEETAALAATAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH60</accession>
    <name>A0A139SH60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000066">
        <property type="protein sequence ID" value="KXU33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU33897">
        <property type="protein sequence ID" value="KXU33897"/>
        <property type="gene ID" value="AXK12_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="62" mass="7077" checksum="C9C08FE60BA88906" modified="2016-05-11" version="1">MLTISTDKQVITPFCPLSDNQNAPRFNIQVVEIEMTLAVRENGITMIFKIHYTPSAAYNYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF6</accession>
    <name>A0A139SHF6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S55 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_08085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713243.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08085"/>
    <dbReference type="EnsemblBacteria" id="KXU33987">
        <property type="protein sequence ID" value="KXU33987"/>
        <property type="gene ID" value="AXK12_08085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299251" description="Peptidase S55 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S55" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="623" mass="67156" checksum="7B632D37E78794DD" modified="2016-05-11" version="1">MRLFSLLLLLGLQCLMPLQARQQPQSPEFIGLDELRPGMRGEVWTVFRGTEPEPFEVEFTGVIHNGLGPGKSLILCELTDKRVQKMGAVAGMSGSPLYIDGKLAGALSYQVQKFETVRYAGFTPVADLIEVGEKSQKSLGRLSASHSPSLKESRQTGDSGLKPLTPVFMLSGVSPRVVDWLRPHFAQLGLQVGALGGTATSVNDRANDGRPTNGSAPRTHPQNKKGLSPLNAGDAVAVALTTGDITLAATGTVSYVAGDRLIAFGHPMMSLGEVALPMARAEIVTILPSSENSVKIANTGELIGTINQDRLSAIAGAFGDAPPMLPIEITIEEMKSENSAPETNDDTLAQPVPPLGRSLKFHAVQHPQLTPLAIGIGAAQAAIGSNDAGLSQGARLVAEFHFAGEAPLRFETLLPGSQGSMQGIGELVRGINALMQNPYEPVFPTEVKLRLTPLAENPITTIETAQLSRSEIAPGEVLTLTLQWRNFQGEVGRELVRIPVSPEWLGRSLEIIIARGELLDQVTERQFIQTSTQLRSFSAFLDFVREGRNSEGLHIAVVENSRLFLDQATPTRELPGSLARIATRADSARYQNRQASAVLWETRILPDRLIPSAHRLSFKVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF9</accession>
    <name>A0A139SHF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_08225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713288.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34008">
        <property type="protein sequence ID" value="KXU34008"/>
        <property type="gene ID" value="AXK12_08225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021913">
        <property type="entry name" value="DUF3526"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12040">
        <property type="entry name" value="DUF3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="470" mass="51260" checksum="198FE785F36894D1" modified="2016-05-11" version="1">MISTIVRHEFKGALRDGRFRWAGIIIALLLLAALLAGWSYHREISAQRHHASLAEQERWLAQPEKNPHSAAHYGIYAFKPRLSPALLDPGVEPYAGVTTWMEAHKQNDVLYRPAEDATAAQRFGDLTVALILQLLLPLLIVAVGFSAVTAERERGTLRQISALGLSPTRWLFGKAAGLAAAFALLAVPALLLSGLVLAGLQDAATENAWSRFGLMALLYLVYLGVFLFLTLGVSATVRSSRASLIILLGVWMLNGLLVPRMLSEIAAGRYAIPSVATVKNEIQRRQQNPEYAVRARAIWEPRVIERYGLSGVEELNGLSSRGLSLLRGESAGYLVFDEVYGELHDVIEAQNAYQRARSWIAPLAALQPLSRALAGTDFAHHRHFIESAEAYRRLVQDTLNEDILINDGKQGSGAYLAGAELWAKVPPLVISAPSLGDALRGQAVPLIALAAWFAATLAFFTTAARRLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG5</accession>
    <name>A0A139SHG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">AXK12_08315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713316.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08315"/>
    <dbReference type="EnsemblBacteria" id="KXU34022">
        <property type="protein sequence ID" value="KXU34022"/>
        <property type="gene ID" value="AXK12_08315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="267" mass="27489" checksum="0219F9EC684D921F" modified="2016-05-11" version="1">MSVIAFLGAGNMAAAMVGGLLKNGHAHAALRCYTESGQSARALSALTGITRAESIPALLAGADLLVVAFKPQHLATRDAALVEASSGKLIVSVMVGKTLAQLQSAFPHARAWVRAMPNTPGKIGAGVTGWCAHTTLADADRALVDSLLSPLGLALEVTEAQINDIAAISGSGPAYFFEFAAALSAAAQQIGFEPEVAKRLVTQTLLGSAQLLAQSGAAPETLRNQVTSPNGTTLAGLRKMEEARLRETVLATVRAAQARGLEIARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI3</accession>
    <name>A0A139SHI3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713255.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08120"/>
    <dbReference type="EnsemblBacteria" id="KXU33993">
        <property type="protein sequence ID" value="KXU33993"/>
        <property type="gene ID" value="AXK12_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299243" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="75"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="765" mass="83333" checksum="24374365166B426A" modified="2016-05-11" version="1">MKRNTPLRVACAAFLLCTAPIGFAQRSSGESPASARAAESEETVILSPFEVSSYQPARYQADEAASGGRIVTNVLNTPSTVTVLTSDFVADIGGNRIFDSAKYVAGINDATIPNAQDRANIRGFAMGSRLVDGFSTPSQSNYDHAAIDRMEISKGPDSVLQPAGVPGGSINLVTKKPQWAFGGSLKAQLGEYETNRVEADVTGPINDRFAYRLIAAAQDNKSWVQGTFRESLLVTPSLTWRIAPATNLTLRYEYYDARTSNLEGIPMDPMVGPDDAFRTMPGVPLDFSAAPGEEYSYRMSRSNTVTMLLTSVITDRLSVRLAGRLAQSTHPNGDFRWGLDTPGGSINPFTGKWEGGVRWQNTSADPANPNWVSGPAPQPSNVFQHVGTYEAVEGRYRDLQNDWSYIVDNDLVKSSTLVGFAYSYSHHNIQSRRQELPDFTVDNVPHEPVTTYPNNTDRRGITTSYQSYLTQSLEFLDSRLVLSGGVSHSSYNGVFGNKLSAATATAPAGMMYPGSGSKATYNYGIILKPLANVSVYYGHSENAVPANNFQQTYEGRDPFSEGTQDEVGLKLRLFEGRILASLAYYEIEQTGYTVFNPLNVVVPPPPVLLPDLVLSRKASGYELQIMGSITPQLSIIASASDTKNRDPNGVMLRGSAENMASGFVRYEFTTGRFAGLSAGLGANWSSKRSVENVSGLTPMGVPIQPRGYLPARTLVDAYIGYERGPWSYRVDVTNLTDKLYYSALSWNIIQVANPRAFAGSVTYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ2</accession>
    <name>A0A139SHJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_08180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713274.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34003">
        <property type="protein sequence ID" value="KXU34003"/>
        <property type="gene ID" value="AXK12_08180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="169" mass="17796" checksum="45CBDE6A2C3DB868" modified="2016-05-11" version="1">MSPTALAAGKGALGVLVSRQRSGRRFLFWLRSLTARRLQLIAFLLAGLLTTGAQWDAVQVLAWARMTVQSLNAGTAWEAALADTFSGELCEICEAVDEARQAQHSPAGAATTPKGGKLLLAVYPAADELIFSEVSAVDVAGRWSLSDQVGRSIERGAPPAPPPKSQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ7</accession>
    <name>A0A139SHJ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_08280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08280"/>
    <dbReference type="EnsemblBacteria" id="KXU34016">
        <property type="protein sequence ID" value="KXU34016"/>
        <property type="gene ID" value="AXK12_08280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="415" mass="43911" checksum="7D546D10225D14E0" modified="2016-05-11" version="1">MREPSRRVVVTGLGAITALGHDAEQFWAALVAGTPGVRRVQRFDPSPFASQVGAEVLDWDAAQHMDPKEARRNDRYTHFGFVAAKQAVADSGLVMDGEDRDRVGVMIGSGIGGMYTYESQLAVLAERGPRRVSPFTIPSLIGNMCSGMVAIEYGVRGPNFGLVSACATGSHAIGEAMHTIQRGDADVMIAGGSEAAITPFAYATFCAMKAMSEHNDEPARASRPFDRARDGFVMGEGAGILVLESLEHAQARGARIYCEVAGYAASCDAFHITQPDPEGRGLLLAMSRAIEKAGLAPSDIDYINAHGTSTPYNDKFETLAIKKLFGAHAQQLAVSSTKSMTGHLLGAAGGIESVISVKTIQTGTIAPTINLDEPDLPDCDLDYVPHTARAKTVRAVLSNNLGFGGQNAALVFKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHP5</accession>
    <name>A0A139SHP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="3">SDH</shortName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroE</name>
        <name evidence="6" type="ORF">AXK12_08125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08125"/>
    <dbReference type="EnsemblBacteria" id="KXU34041">
        <property type="protein sequence ID" value="KXU34041"/>
        <property type="gene ID" value="AXK12_08125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="172"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="328" mass="34627" checksum="46940EDBD9CA07DC" modified="2016-05-11" version="1">MTDTQRVLTLADLEQGDLSFAQTSLAVLGHPIAHSLSPQMHNGALAALAKEAPQLADWRYYAIDVPPADLPRALRLLRKRGFLGLNLTIPHKVLALAHVAEIDPAARVIGAVNTLRRLGGANDDQPAHAGGDQCDSLGDGWQGFNTDGYGLAAAVRETLGLDLSGQPVILLGAGGAARGAAVECLAQGCPSLWIANRTAANLETLLSELAPLADKSRRGEKNRLHGFSPARVPDDLPAHALVINATSAGLRESDPMPIDLPALPRPAGVYDMIYNPPETPLLHRARKLGLPRANGLSMLVHQGAKALEIWSGIAASRIAPLMQKSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHW0</accession>
    <name>A0A139SHW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713216.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07995"/>
    <dbReference type="EnsemblBacteria" id="KXU34111">
        <property type="protein sequence ID" value="KXU34111"/>
        <property type="gene ID" value="AXK12_07995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="30735" checksum="6F6513A77D0EC761" modified="2016-05-11" version="1">MQENRPKAFFLSLGLHAALGAAIVFFSYTVRARVKPQPHLFELVAGPGENYAALEAPLGDDSAPAETAIRFELPEPPPSPVREPEPPAPPPVLETAPEVSPIELAPEAPNPESPKPAPPPRRNDNATPKPAPPKPEPKPMTKAEFDRLHGNKPNPTAVKPTANRPAPPVRQISTRGIVGGSPSVSEGAGGTALSRAESDLLEAYIALLRQRLRAAHTKPAGLSDLLQAKVRFAIAADGTLSNLRIVTSSGSREFDDSVLAAFRKVRSIGPTPNGKADTWELTFKLRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHX2</accession>
    <name>A0A139SHX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713150.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07835"/>
    <dbReference type="EnsemblBacteria" id="KXU34178">
        <property type="protein sequence ID" value="KXU34178"/>
        <property type="gene ID" value="AXK12_07835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="31831" checksum="5C1DE33076A4BE4E" modified="2016-05-11" version="1">MRLAVIGDIHGNLAALEAVLAELEQVAPDQIVVSGDVVDGGPDSALCWERVKSLGCPVLRGNHERYVFDFGTVRADPVWATPQFAPLHYTLENLSVAQRAELAALPLSWTSRDWPGLLIVHASQRSDADSIWPHTPSEALDLMFSQNAPPLIVRSHNHFCSTREWRGRRLVQEPRRRIVTTGAVGLPLDGHPRPQFCVLTRSRSAAGRPAAIRVEHRNVAYDVEATLRRCQETGYTARAGVLGRMFMREIATGAPQVVPFLRHFNLLKTARPTLSLEEAEQSYRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ5</accession>
    <name>A0A139SHZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">AXK12_07750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713128.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07750"/>
    <dbReference type="EnsemblBacteria" id="KXU34166">
        <property type="protein sequence ID" value="KXU34166"/>
        <property type="gene ID" value="AXK12_07750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="204" mass="21183" checksum="F3950C833506B840" modified="2016-05-11" version="1">MNIRQMWAAKLAGLSVPRSGGARGRSSASAITAARQAGGAHAGRGAFEGQVLGIDPSLRGTGLAVVEFRTGRMPLLLHCRTVTISPRVPMPEALATIHRAVSAALDGHEVQHVAVEQSIYVQNFQTAQILGAARGAAIAAAALRALPIFEYGPTRIKQAVVGTGRASKEQMQKMVMGLVGHGATLAPDEADAAGAAICHAFTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI36</accession>
    <name>A0A139SI36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_07905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07905"/>
    <dbReference type="EnsemblBacteria" id="KXU34206">
        <property type="protein sequence ID" value="KXU34206"/>
        <property type="gene ID" value="AXK12_07905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="439" mass="48379" checksum="AAD0FDE014204FB0" modified="2016-05-11" version="1">MWLYRALYPFALLIGSPFYLRRMWRRGGYREGFSHRFGRVPSLPAKREGVSRLWLQAVSVGELLAVAPLLEAWAREGHEVYLTTTTSTGYRLARERYGALTIGIGYLPLDWWPFSRNAWAAVQPDVALLMEGERWPEHIAQAARRGVSVVCLNARLSDRSFRRMRRCLWAIEPLFGGITKILACAEEDARRFRALGFAPDRVITTGNMKLDVAVPVLDAGAKAQLRSELGLRPVESGELILMGASTWPGEEAALISALRSLRVKGIACSLLLVPRHAERRAEIVAVLRESGFRYRIRSEYLSESRSDSECVDVSLADTTGELQRLLQVADLVFVGKSLPPHTEGQTPVEAAILGRAILFGPGMGSFRQIARELVDCGAARVVGDSQALAAQACKLLLDSEKREAMGAAGRAWHAQNVGALARTLEATSELFAKPAASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI79</accession>
    <name>A0A139SI79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">AXK12_07350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712975.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07350"/>
    <dbReference type="EnsemblBacteria" id="KXU34288">
        <property type="protein sequence ID" value="KXU34288"/>
        <property type="gene ID" value="AXK12_07350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18277" checksum="6BB2C584BFA6968C" modified="2016-05-11" version="1">MRHCIYPGTFDPITNGHLDVLHRAAKLFDHVTVAIARSSTKAPFFSTELRLAMVEETIREIPNVSATVFDGLLVNFASEQKAQAIIRGLRALSDFEFEFNMALMNRHLQPTLETLFVMPSEQFSYTSSTLVKQVAKYGGDVTHFVPPIVATALKRAAEARGHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB7</accession>
    <name>A0A139SIB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712971.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07340"/>
    <dbReference type="EnsemblBacteria" id="KXU34286">
        <property type="protein sequence ID" value="KXU34286"/>
        <property type="gene ID" value="AXK12_07340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="28679" checksum="FC158125B9FC95E7" modified="2016-05-11" version="1">MSTSPVVELHDIRKTYASGEATVHAVRGISLKIERGEFVAIMGASGSGKSTLMNTLGCLDRPTSGQYLLDGTDVSHLDRDELADIRNHKLGFVFQGFNLLARTTALENVELPMLYGAENLPKAERRERALRSLEIVGLAERAHHYSSQLSGGQQQRVAIARAIANQPQLLLADEPTGNLDSKTSIEIMGVFQRLNDAGMTIIMVTHEPDIARFCKRDLLVRDGLLVSDTTVSPRTLADEELRRYLANAPKDEMPSTATPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE0</accession>
    <name>A0A139SIE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713034.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07525"/>
    <dbReference type="EnsemblBacteria" id="KXU34317">
        <property type="protein sequence ID" value="KXU34317"/>
        <property type="gene ID" value="AXK12_07525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="424" mass="46237" checksum="665E1583BF539B0D" modified="2016-05-11" version="1">MHLLDLTHTAHTRVQTGIQVVCRALYAELAKRDAARPITWDRYAKEWRELQAWEQANLDLHAKRDDERSPSTSNTPTVTQKKAHAKRSAQWPLSARVNGRLRRLCRALGAPCADSLATHAGATASKHNSASGLIIPELFAPSLARYHAQLRVQGPRVAIFHDAIPLKYPELSPAKTVAFYPGYLHSLLQFDGIAANSEDSAQTLRDYFRWLAPARTPQVTAIPLGVNLPATIPPPLTFDASAPSSELPTILSIGSIEGRKNHLSLLDAAESLWARGRRFTLYIIGLAQAETGRAALEKIRALQAAGRPLRYPGHADLATVEAAYAECRFTVYPSIIEGFGLPVIESLARGRPCICSGKGALGEVAAGGGTLTLDEMTSPAIATAIDTLLQNPDTLSQLATEARARRFRTWAEYTDSLLDWMSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF4</accession>
    <name>A0A139SIF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-glucosidase/alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07645"/>
    <dbReference type="EnsemblBacteria" id="KXU34355">
        <property type="protein sequence ID" value="KXU34355"/>
        <property type="gene ID" value="AXK12_07645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="8">
        <location>
            <begin position="229"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="508" mass="55922" checksum="6322C739F542F485" modified="2016-05-11" version="1">MPRKPANRSRAPKSIGHTSHTQDAETHGLAGECLRPIKITLLGAGSGFTPRLINDILRIPGNRGGTIALVDIDAKRLSTMVKLIKRLVEQLGGAGVWAIVGSAQRREVMADSDYLINCIEVSGTDCVDYENDIPAKYGIDQCIGDTLGPGGLFKALRTVPVFLDVLRDAEELCPQAIVLNYTNPMGMMCLAAGRTSPMQVVGLCHSVQGTSQLLAERAGVPLSEIEWECAGINHLAWFTKFEHGGRDLYPLLKRKAEAELKRAFKDGRPKNPQRTSPSAWEAAEWHRDIVRKDMMLHFGAFITEGSGHLSEYLPYYRKRPDLVQKYAREGYDGGSRFYASNWPTWRTLADAQRDRWLAGEEPMEWERSWEYASWIIEAREKDTPIRIHGNVMNNAANPRAGSGSGGAGGQLITNLPSDGCVEVACMVDRGGIHPTRYGALPAHMAALCASNMSMIDLGAQACVEHSIEKAIYALMLDPLTAAVCSPAEIKEMTLKLFKAEKRFLPKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIG3</accession>
    <name>A0A139SIG3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xylB</name>
        <name evidence="8" type="ORF">AXK12_07650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713078.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07650"/>
    <dbReference type="EnsemblBacteria" id="KXU34339">
        <property type="protein sequence ID" value="KXU34339"/>
        <property type="gene ID" value="AXK12_07650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="319"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="515" mass="54603" checksum="9DD7C2C037D30F3A" modified="2016-05-11" version="1">MSLFIGIDSGTQSTKAIVLDLAQRKTLARAQAPHHLIEGLPAGHMEQHPQDWCAALDTVIAAVVAKIGARRAKQVRGIGISGQQHGLVVLDAAGQPIRPAKLWCDTSTTKECELLTAKLGGAKAVLRKTGIPFLPGYTAPKLLWLKRNEPANFRRLFGKGKGARGKVLLPHDFLNFYLTGRAFMEYGDASGTALMDVRRRQWSRAAVDAIDPRLAEVLPPLSRSDEIVGTLLPEIAAKYGLSSDCIVSAGGGDNMMGAIGTGNVRPGVISASFGTSGTIYAYSQSAIVDPEGEIAAFCDSTDGWLPLLCTMNVTTATEAVRNLFGKDHDAFDAAVASVPAGADGLLLLPYLAGERTPNVPDGSGVFLGLTAQTISQAHLARATMEGVTLGMNYGLRRLAKLGVSAKEIRVTGGGARSAAWRQIMADVFGARVVPMLEDEGAALGGAIQAAWALERQSNPKAKITALTDSLVAVDEARACRPDKTRHAIYCEIQAVQDKLSTSLREVFARQRALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIG4</accession>
    <name>A0A139SIG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_07560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713045.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07560"/>
    <dbReference type="EnsemblBacteria" id="KXU34323">
        <property type="protein sequence ID" value="KXU34323"/>
        <property type="gene ID" value="AXK12_07560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="371"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="404"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="623" mass="68029" checksum="A394A665DCD8B7D8" modified="2016-05-11" version="1">MAEPAPSNAAPPLKNSALIRRLFGLAWAYRLHCVRVLFLQLVLLTIGIAGLSFTGLGIDYIRSHVEGVSFDATVFGLVPPAAWPPLYVLAALACGVLLLALARAVLNFLYAVSINRLVQQKLVVDLRAEVYDKLQRLSFRFFDANNTGSIITRVTGDVQAVRMFVDQVLMQSVIMVISLTVYVAYMVHLHVGLTLACLATTPLLAWLSTWFSKKIEPEYRLNRTLFERMIQSFSESIQGIGVTKGFGREAEDRERFGRANRAVYEQQRGIFWKVSLFSPAVGALTRINMVVLLGYGGWLVIDGQLPLGTGLIVFAGLLEQFSGQVNSVATLVNSVQQSLIGARRVFEILDSPVEVQSAPDAVRCGRLRGAVCFERVSFAYTGITPVLRDIDLEVAPGQCVAILGPTGAGKSVLMSLIPRFFDPVSGRLLIDGLDARDLHLDDLRRNIGLVFQESFLFSNTVAANIAFGCPDATSAQIEKAAKIAAAHDFIMALPQGYDTVLGESGSGLSGGQRQRLAIARAVLLEPSILLLDDPTAAIDSETEHEIFEALDRAIAGRTTFIVAHRLSTLRRADFIIVMEEGRIVQRGTHAELMRQPGAYRRVAQLQLIDGAALHEEAEGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SII6</accession>
    <name>A0A139SII6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713007.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07450"/>
    <dbReference type="EnsemblBacteria" id="KXU34304">
        <property type="protein sequence ID" value="KXU34304"/>
        <property type="gene ID" value="AXK12_07450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="432"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="590" mass="62860" checksum="12EDA3A8101C7518" modified="2016-05-11" version="1">MHNIDLILTLTGGFVAALTFGYITQRIGISPIIGYLFAGIVVSPHTPGFNADPELAEQLAEVGVILLMFGVGLQFHFKELLAVKRIAVPGAVVQSLTATVLSALILHYGFGWGWPAGVVFGLAVSVASTVVLIRVLADNGDLHTVTGHISVGWLVMEDLFTIFILVLLPAIFGAAATGGELALGLGEVTKATGLASLKIGALVAFTFIVGGWVIPRLLTGIAKTGSRELFTLAVLAIALGIAVGSAKVFGVSMALGAFLAGMVVGRSDFSLRAATEALPMRDAFAVLFFVSVGMLFNWQSLLANPWLVTATMFVILVGKPAAALAIVILMRYPLRVALSVAIVLAQIGEFSFILATMSRQLNIIPESATNAMVASAILSITLNPLTYRLIPRIERGTERLFPGLVRWINKRASGGLAGEAAAAHPIASDKQRAIVVGYGPVGQIVARLLRENDFDLTIVELNVDTVQRLKAEGVPVVYGDATRIDTLMQAGVPDARALVLSASSIKDGREVVRQVRELNPDIRIVARTAYLRELEALRDVGADGIFSGEGEVALAVTEHILRDFGATPEQIDRERERVHRELFSPNREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIL5</accession>
    <name>A0A139SIL5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">AXK12_00430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712895.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00430"/>
    <dbReference type="EnsemblBacteria" id="KXU34415">
        <property type="protein sequence ID" value="KXU34415"/>
        <property type="gene ID" value="AXK12_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="526"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="661" mass="73054" checksum="DC07CBB29A171D6A" modified="2016-05-11" version="1">MATLNSNVPPGPLAEKWSNHKFNNKLVNPANKRKYEVIVVGAGLAGASAAASLSELGYRVKCIVFHDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVHRLAEVSANIIDQCVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLLLGAYSALSKQVGAGAVELVTQHEMVDLVVIDGHAKGVITRDLVTGEFHRHSGDAVVLATGGYGNVFNLSTYARGSNATAIWRAYKRGACFANPCYTQIHPTCIPVSGDYQSKLTLMSESLRNDGRIWVPKNASDCKKNPNDIPEEDRDYYLERIYPSFGNLAPRDVSSRAAMRMCDEGRGVGESGLGVYLDFADAIQRYGHQAAARANLTNPPAEQILALGEAAVRERYGNLFDIYKEITDEDAYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGLFVLGEANFSDHGANRLGASALMQGLSDGYFVLPNTINGYLAGQKPNNKPSTDAPEFVEAEERSADVVRRLMSVKGKEPVNHYHKRLGLIMWKRCGMARTREGLQKGIEEIQALREEFWAGVNVPGSAENMNQALERANRVADFMELGELMCRDALAREESCGGHFREEYQYPDGECLRDDEKFAHVAAWEYQGEGVEPLRNVEPLDYEFVKMSMRSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ40</accession>
    <name>A0A139SJ40_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_07105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712790.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07105"/>
    <dbReference type="EnsemblBacteria" id="KXU34514">
        <property type="protein sequence ID" value="KXU34514"/>
        <property type="gene ID" value="AXK12_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="206"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="475" mass="52840" checksum="584C9B64A6282B57" modified="2016-05-11" version="1">MISSPRTTTKRSRSSPSRDRERDEESAMQPLGRTLPHSVEAEQHVIACCLIDGSDTIARCLESKLSENAFYDPANRLIYRKLCEIYQTKPPVDIAVLAEELRIARELDQVGGPAYLSQLSLSIPTTAQAQFFIGRVRELHLLRELIKTATGAVEQCFNYEGGLESFIDKIEQEIFSVTQDRISDAAKPIGGPMKEAVEVLHKMMDKKGELTGVSSGFKDLDTLMYGFQRQEMIVLAARPSMGKTSLALNFAEAAAMPRHGVAPTATLVFSLEMSAAQLALRLLCSRSRVNMKLLREGLLPRNDDAQTRLVHVADEFTKSPLFIDDSSHLSIMELRAKARRLHARTKLGLIIVDYLQLLSPTDAQVPREQQVAEASRGLKALAKELDVPVIVLSQLNRASEKENRVPKLADLRESGSIEQDADVVLMLARPKDADEKFQVAADSAELIVAKQRNGPVGELKLTFLRDITRFENYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ65</accession>
    <name>A0A139SJ65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">AXK12_07140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712801.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07140"/>
    <dbReference type="EnsemblBacteria" id="KXU34520">
        <property type="protein sequence ID" value="KXU34520"/>
        <property type="gene ID" value="AXK12_07140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006273">
        <property type="entry name" value="Orotate_PRibTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01367">
        <property type="entry name" value="pyrE_Therm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Orotate binding" evidence="4">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="189" mass="20606" checksum="83D586A53209229E" modified="2016-05-11" version="1">MDDIQREALAIFRETGALLEGHFILRSGLHSGHFFQCARVCEQMAQVERLTAMLAPKLGEFTFSTVLAPAMGGLVIGQEIARQTRSRYLFAEKQDDRLVLRRGFTLAAGERVLIAEDVVTRGGRVRECIDIVRAAGAVPVAVAMLVDRSAGVARFDIPAISLLQLSFPTYEADKLPPELATLPAQKPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJL0</accession>
    <name>A0A139SJL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712774.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07060"/>
    <dbReference type="EnsemblBacteria" id="KXU34694">
        <property type="protein sequence ID" value="KXU34694"/>
        <property type="gene ID" value="AXK12_07060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002111">
        <property type="entry name" value="RpsA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="355"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="442"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="553" mass="61508" checksum="C881AFA20C07400F" modified="2016-05-11" version="1">MQDLLEQSSFDKLKEGSVVSGTITEIRQNEVVVDIGGKSEGLIPAHEFIDIGELQIGSQIEVLLEKLEDKTGNPVVSFDKAEQKKNWENILTTFPEGSVATGRVKAKVKGGLIISVGVDAFMPASHIDVQPPKNLDQYVGQTYDFKVLKINPERKNIVLSRRELIEEQRAEKRRTLLDSIEPGQVRKGIVKNITDFGAFIDLDGMDGLLHITDMSWGRISHPSEMLKQGEEIEVMIIEVNRDKERVSLGLKQTTKNPWDEIDRKYPVGAKIAGKVVNLVPYGAFVELEPGVEGLVHITEMSWTKRISKPSELLKVGDEVEAVVLGIQKDEQKISLGLRQLEPNPWDMVRHNYPVGARVRGKVRNMTTYGAFIELEEGIDGMVHVSDMSWTRKVNHPSEVLKKGDEVEATVLDVDAQQQRISLGMKQLSDDPWSDIDSHFKIGDVITGTVTKLTSFGAFVDLKDGIDGLVHISQISEDRVEKVKDVLSAGQEVTARVIKIDREERRLGLSIKAANYSSEELAAETASFEALNRQSGTDMMNLGDILDAAHDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR7</accession>
    <name>A0A139SJR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">AXK12_06770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712666.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06770"/>
    <dbReference type="EnsemblBacteria" id="KXU34786">
        <property type="protein sequence ID" value="KXU34786"/>
        <property type="gene ID" value="AXK12_06770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="22954" checksum="A2572AE0C4945348" modified="2016-05-11" version="1">MKLTVFSSDGKTSTEQEFAGLPVFEGDKGRQALKEVIVAINANRRQGTHSTKTRGEVRGGGKKPWRQKGTGRARAGSSRSPLWVGGGVVFGPKPRDYSKKVNAKVRALAFSRAIFERASAGELAVIEQFVLPEPKTKLMNEVVGRIAPKGNILLVDAPFSDEAFRAARNIERVSLQEAAELNPVDLAKYRKIIVSTGALERILSRINGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK13</accession>
    <name>A0A139SK13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="11" type="ORF">AXK12_06560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712578.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06560"/>
    <dbReference type="EnsemblBacteria" id="KXU34891">
        <property type="protein sequence ID" value="KXU34891"/>
        <property type="gene ID" value="AXK12_06560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="10">
        <location>
            <begin position="1"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="939" mass="101451" checksum="BD45B00B3DC87056" modified="2016-05-11" version="1">MTSAEIRQSFFDFFAQRGHTIVPSAPLLPSSPGLLFTNAGMNQFVPIFLGEAEPRVSQWAGARPARDTRAADTQKCIRAGGKHNDLEDVGFDTYHHTFFEMLGNWSFGDYFKADSLRWGWELLTQVWGIPAKRLFATIYAPDKAQGDPADFDQEAYDIWAEIFKNAGLDPALHIVHGGKKDNFWMMGETGPCGPCSELHFNLLPDDDEAAGRALVNRDSPRCIEIWNHVFIQFNANADGSFAPLAAKHVDTGMGFERVAGLYATTRGFTDFTAEPSNYAADLFAPLFAEIAARSGKHYAGTVPARRDHLSEQEQIDVAFRVLADHARCLTCAIADGIMPGNEGRNYVIRRILRRGILYGAKLGLKTGFFEKLVAPVVASLGPVFKEVAEQEKIICRIIRSEEESFGRTLERGLTLFNRAAGNAEAQAAPHAESAHAKKLSGEAAFELYDTYGFPLDMTQLLATERGLSVDTQKFEALMEQQRERARAAQKKEIVVAATEGSETGTANAAALTPTRFVGYTQLDASATLVELIRSEGAKKADTTAATYLVFDQSPFYAEMGGQVGDTGKVTIGKETLRITDTVKDGNDRHLHRIHTDDTAAADALTVGNSATLSVDAEARAAITRHHTAAHLVHWALRQVLGPHVRQAGSSNTTQRLRFDFSHFEAMRPEELREVERLVNARILENAEVQAYETEFDKKPADTLAFFGDKYGHIVRVVDTGGFSRELCGGTHVTRTGEIGLIKLVGESAIAAGTRRIEAVAGQAAYDLVATEEAALRALCARLGASPSDALARLDALLDTQKELERKLKSFSQKAAAGLADELTAKAQPLDAANAAAEPTAALKRVIAVVEVESPEALRTLGSQVLAKLGEGVVQLGAAFGEKATVVAFCSPAAIAAGYQAGKLVAALSAQIGGKGGGKPDFAMGGGAVSDRWHSWRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK30</accession>
    <name>A0A139SK30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712547.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06470"/>
    <dbReference type="EnsemblBacteria" id="KXU34876">
        <property type="protein sequence ID" value="KXU34876"/>
        <property type="gene ID" value="AXK12_06470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="206" mass="22452" checksum="10D44A2C60BFAC16" modified="2016-05-11" version="1">MSEHPAPLVHLVDDDASVRAALEDLMASVGLSARVFASVAEFLAEPLPDAPGCLVLDVRMPGQSGMEFQRQMHALGIHLPVIFITGHGDIAMGVAAMKQGAIEFLTKPFRDQELLDAVWNGIELDRKRRAEAAALADLRSRWDSLNPGEQSVARGVVQGLLNKQIAAELDLSEITIKVRRSHVMRKMQAKSLAELVRMMEALPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK32</accession>
    <name>A0A139SK32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712613.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06670"/>
    <dbReference type="EnsemblBacteria" id="KXU34911">
        <property type="protein sequence ID" value="KXU34911"/>
        <property type="gene ID" value="AXK12_06670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="182" mass="19060" checksum="503019CD0B9F6628" modified="2016-05-11" version="1">MTTTQTTPARNAATATDWAKIRLFAMDVDGVLTDGTVQIASDGTEAKVFSILDGMGLVRLARAGITTAWISGRPSEATTRRARELGIPHLIQGRTDKLAALSELAARLRLSPEHCAYMGDDDIDAPAISWAGVGIAAPEAMPSALDAANYVPARAAGRGAVREVCEHILGAHRGTEAAAVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK35</accession>
    <name>A0A139SK35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712440.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06160"/>
    <dbReference type="EnsemblBacteria" id="KXU34948">
        <property type="protein sequence ID" value="KXU34948"/>
        <property type="gene ID" value="AXK12_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="790" mass="86289" checksum="023AF3869E115351" modified="2016-05-11" version="1">MRAAIADGGDLVELDRYEVAGLRLEDSINPLARASDGIFGDMRGPLDTPRAVSTVTQALLRERGISGVREFTAYAAGTSAPSSYGSLSTPNIRGDVAETFLNGQRLSYNRFGVLPSFNGVEAIEVVRGPGSAIYGSGLLTGGYVNYVTKQPQFTPETTLTLRMGTWVPGGGAGAASWLNSSWQVDTTAPTAGGRSAWRLSYEGKADKTFFRRAGARDDRQDLFLAWTRRPAGHSSGGLTLDANAQVLWQAAPQVLGVNRPTQELIDHGIYYSGAVPNLGINPKTGAPAGTINGVTKAKLPRDATLLTPADFSNALLARAQFIATAQPSADHKFISRTFGEYTRRRRYNSSDENTEYREQFTLETRGEWQARAEFLGRAHALVAGGTLRYEERESFVNYFNGYPFLYDLSAPRGAESPEQPAYSFVRDYVDSYLEGIPGGPGGRLFFASSQGVPETSDSALWNPALFVQDDVALSERLGLLAGARLDAYAAKARDPLGAVTGIDWSDTHSETAFSWNGSLRYTLPPSVGSGMFYATYQRAYSVQGHTSGGGIMLKRDPNDPTRGIIEPSEFTPLSRLTELGAKFALSENALYLGLALFEQQRIQVGRGGINRTLKSRGTELELVYQPNARFNATLNASLSDVRYLNTSLSHSGGNSLYNIYETGTGPGGLGNGRGFVWESFPVGDYRVTGHSRLMLNSSASYQLKSGFGAGFVASWQSEQLGNFANEYHIPEQVFLDVYLFYRGPKWSVNLDILNVLERRNWLHNGDNLSSHSLIWQDLPMRIEGYVKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK47</accession>
    <name>A0A139SK47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712463.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34959">
        <property type="protein sequence ID" value="KXU34959"/>
        <property type="gene ID" value="AXK12_06215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="468" mass="50578" checksum="0946CA826DAE4B95" modified="2016-05-11" version="1">MKPLLAEARDRLDAKDTQAALAIYEKLLAEDSGVAARADVLVTISGDLGSTGHLREITELVGPHYDAQKHGPATGLNLLQAYIALRNVDAAQHILDILFGLGRPELEDRLHGFSNAIAELMAQGQFAPNAPVSPSVGPAETSAATGTAPSPSAHVSLVTISKPIWSYGLEDALGELFPVREAEKNVRRVAFAQLAVLGLEDTHELAAKPEDELGRLSRAIPLWLAETFSYSPLYAPLAAVGVRHSSGTPGHYALFPSEWTTENLRQLVEASGAEARGLDYIFTGSLQEKNADTTLTLRVWEVRKFRERKKIVLRWTPASADAELAKLHAYLRQFMEWRDGSAGEPRAAALRYSPPAQALRWLHTLGTSLTLFLAGKDVLARDQIPPLKALIRDALSAAQREKESTATALASLTLLARARDLRAIDETDLVELTKTLDAATSLDDGSARTSPDSEQSKQVATARSALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK69</accession>
    <name>A0A139SK69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">AXK12_06450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712545.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06450"/>
    <dbReference type="EnsemblBacteria" id="KXU34874">
        <property type="protein sequence ID" value="KXU34874"/>
        <property type="gene ID" value="AXK12_06450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="188"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="502" mass="55577" checksum="26789EA565543A53" modified="2016-05-11" version="1">MSETTLDTSDISHDQHAVRLAKLRELQAAGRDPFRASFTPTHFSGEALAAYAEGEAGSASSEPAAAELSVAVAGRLVVIRDMGKSQFVKILDQQGQIQLYVKKDAVGEEAYAAFKRLDLGDIIGAAGTLFKTKTGEVTVRVERYTLLAKALRPLPEKWHGLADTEQIYRQRYLDLIVNADSRRRLVQRSRIVSHIRRFLEARHFIEVETPVLENTAGGAAARPFVTHHNALDTDFYLRIATELRLKRLLVGGLDRVFEIGRIFRNEGVSRRHNPEFTMLEVYQAYSDRVGMMGLIKALLTSLCVEVLGTLQIPHAASGQVIDFAGEWREVRYKTLICEKTGVPDWFALPKAEKVARATALGCKIDPAWEDYEVTNEIFSKLIEPTLIQPTFVTHLPKELCPLAKLDSEDSSTIDVFELTIGGMEVAPAYNEQNDPHVQRAMFEAQAGGETQNIDHDFLLALEHGMPPAGGMGVGIDRLCILLTGAESIRDVILFPAMKPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA1</accession>
    <name>A0A139SKA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712626.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34917">
        <property type="protein sequence ID" value="KXU34917"/>
        <property type="gene ID" value="AXK12_06715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="155" mass="17544" checksum="5017BFF82D47DDC7" modified="2016-05-11" version="1">MPKIDVNKVAEILKKNELEPALLRRVLDELRLAVQPDPSEEDKPPPIKKQFVILVSDPEHKLPKDDFVGWVLQIPEEDNVGTTPDRICRAAYDFNDTKKGSLLPVSTIGETLENVPAKHFKEYNTWVKTKEPVLVVRTDNQVPKETVEMEPGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKB3</accession>
    <name>A0A139SKB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsJ</name>
        <name evidence="7" type="ORF">AXK12_06755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712638.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06755"/>
    <dbReference type="EnsemblBacteria" id="KXU34924">
        <property type="protein sequence ID" value="KXU34924"/>
        <property type="gene ID" value="AXK12_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="6">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="102" mass="11520" checksum="4CF3088463BDB33E" modified="2016-05-11" version="1">MKGQRIRIKLKGFDYRVIDQSAQEIVETAKRSGARVSGPIPLPTRIEKLSVNRSPHGDKKSMEQFESRTHKRLIDIIEPTAQTVDELKKLNLPSGVDITINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD1</accession>
    <name>A0A139SKD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712438.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06155"/>
    <dbReference type="EnsemblBacteria" id="KXU34947">
        <property type="protein sequence ID" value="KXU34947"/>
        <property type="gene ID" value="AXK12_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="337" mass="36794" checksum="26DC79B2239A085C" modified="2016-05-11" version="1">MGELPETNPEVTRGPRASRPKKQRSAIAQIGAITAVAVAVYVGFRVMPTGTNLSHMDFRVEGENTLQMCDPGNPQFLPVVNVRSPVSLALSPSAAVPRAGEEWTTTLRLTTYQGKAIGPADLWRVHTEFLHLMIIDPDLLDYHHIHPQPTDTPGEWQFSFTPRYGGEYRIFADFTPAATGLGLYASAQVLVEGAAPSAEEVTAAQVPSWRSQIAGVDFELKPIAEKGATKAAQAEATSEVRARREVTMRLALSRADGGEVPLLPIMDAFAHVVAFDIGRTGFAHLHPQETDLNTPPDPQNPALTFRVLIPSPGRYVAWAQVNHAGTERFAPFWFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD3</accession>
    <name>A0A139SKD3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_00235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712379.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00235"/>
    <dbReference type="EnsemblBacteria" id="KXU35032">
        <property type="protein sequence ID" value="KXU35032"/>
        <property type="gene ID" value="AXK12_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="30"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="505" mass="54364" checksum="23FECB36C1D776BE" modified="2016-05-11" version="1">MPETEPRDLAQTRSTPAARPSARHPAGLRPLFFTELWERFSYYGMRALLVLFMTSTVSEGGLGFSTERAALVYGYYTMLVYMLAIFGGYIADKIIGARQCVLVGGVIIACGHFAMALQSTASFYAGLGLVAMGTGLLKPNISTMVGSLYAPDDDDRRDAGFSIFYMGINLGALVAPLLTGFLAQHPWFQQKLAAWGFDPQHSWHWAFALAGVGMTIGLIVYTRSLSTLAGVGEGPKIGLAQKGVRLARAVGYLALLGAVGWLLNRVPVLVGVLSVTAVLATIAYAIWGGEDGRRTAAIAVLFAASIVFFAVFEQTGSSINLFARDFTDNRIFGYAFPSAWYQSVNSAFIILLAPLFGWMWLRLGCRQPSAPMKFTFGLGFVGLSFALMVPAARLADQGLVSPLWLIGLLLLQTIGELCLSPVGLSTVTKLAPARLAGVIMGGWFLATSIGNFLSGYLARNFSEEGNDSGALARFFSEQALFVFVATAVLLCLVPLVKRLMRSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKJ4</accession>
    <name>A0A139SKJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_00345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712414.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00345"/>
    <dbReference type="EnsemblBacteria" id="KXU35050">
        <property type="protein sequence ID" value="KXU35050"/>
        <property type="gene ID" value="AXK12_00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="390"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="56"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="511" mass="55553" checksum="41AB7DCB06B39687" modified="2016-05-11" version="1">MKQKTTRTPKPHTAHRNYDLAIIGGGSAGYNAARTATSLGLKTAVIDGAAELGGLCILRGCMPSKTLLHVADTLHAVRHAAPLGLRIPRATPDMPAIQARKRRIIADFASYRQNQLHNGDFALIPHYAHFLDPHTLALSNGETLRARHILIATGSRISTPSSIPGLADAQCWTSDDILDLDFIPKTLVVLGGGIVACELAQLLARLGTRVTLIQRSAQLLRDHSAQAADVIRQSLEADGVEIFTNTQLLRVSRKTARGKASYTIEFEHKKSANSAKRRDASPKREVVTAQHCLNALGRTPHTAPLALDLAGVKTAPSGHILANRWQQTTAPHIYAAGDCTGPHEIVHLAIQQAELAVRHIAAALEAKTAREMTSRRKHLAKEYGRRPLLSVVFTDPQLAQIGLSERDLKTSNTPYLCASYPYDDHGKAILLEATRGYAKVFASPRTGRLLGAEIVGRDSGELIHCFSTPLAMRATVFDMLRAPWYHPTLAEILTYPLEEIADQISAAKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKJ5</accession>
    <name>A0A139SKJ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712350.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00145"/>
    <dbReference type="EnsemblBacteria" id="KXU35017">
        <property type="protein sequence ID" value="KXU35017"/>
        <property type="gene ID" value="AXK12_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="486" mass="55030" checksum="1591BFE31BBFE57C" modified="2016-05-11" version="1">MNKKKLKLGYLLISAIFFTYVLIRAINVGVTHDEAATIEISNYSFLRVLFTIVIANNHIPYTILIKLLFLTGNDSLFIARLPSLLSFIPYLYFGYKITSKNLSGIIGLGCFFLLSSNPFLLEFFSLARGYGLSLSFMLGALYFASENVKTFSPSTLSKSLILGALSVWAVFSMIYFFSALILILNLSTYLKKNKELLRISLKQSAFIGLSTLLLIGMPLSRLIIYGELYYGGTDSFYSDTLVTLTQHSLSKNYRQETAPEVYIILNTLIVVLIGCILISYLRSRKKHTHHSENFFIAITALIILLITSAHYLAGIKYPIDRVALFFYPLFIFCLFYSLRNINKYVRTIISLLVVLGFSLNLIINHNTYKTTTWDFDAHNEEILKAINKIGESNNKLVTLQAEYAFIPPLNFYINRNSYPFVEIVRETDSGYINPVADYLLLWSEPGAGTLALLNAAGVDPSDIYDNDILIEYPEEQIVVFDLIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ7</accession>
    <name>A0A139SKZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712145.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05695"/>
    <dbReference type="EnsemblBacteria" id="KXU35197">
        <property type="protein sequence ID" value="KXU35197"/>
        <property type="gene ID" value="AXK12_05695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="383" mass="40754" checksum="5F5E3F34E3C81FA2" modified="2016-05-11" version="1">MEPPPETKPPAPSAALDALLRERIAILDGAMGTMIQERGLTEADFRSPALADHPQDLKGNNDLLSLTRPDVIEDIHYRYFAAGADIATTNTFSSTTIAQADYHLEHLVPELNRAAAQLASRAARRIEAEAAAIQTPALGDDAPTSASPRNKAERPLRRCFVAGGIGPTNRTASMSPDVNRPDYRAVTFDQLAAAYREQAAALVEGGVDLLLIETIFDTLNAKAALFALEQLFDDLGYRLPVMISVTITDASGRTLSGQTIAAFYHSIRHARPFSVGINCALGGAQMRPYLAELAQLAECYTTCHPNAGLPNAFGGYDETPADMAAILGDFAAHGFVNIAGGCCGSTPDHIRAIAAATAAHKPRTPLPHSHALRLSGLEPLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL12</accession>
    <name>A0A139SL12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable malate:quinone oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">MQO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Malate dehydrogenase [quinone]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mqo</name>
        <name evidence="5" type="ORF">AXK12_06050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(S)-malate + a quinone = a quinol + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:46012"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MQO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.4" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712281.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06050"/>
    <dbReference type="EnsemblBacteria" id="KXU35258">
        <property type="protein sequence ID" value="KXU35258"/>
        <property type="gene ID" value="AXK12_06050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052589">
        <property type="term" value="F:malate dehydrogenase (menaquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00212">
        <property type="entry name" value="MQO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01320">
        <property type="entry name" value="mal_quin_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="518" mass="56117" checksum="FC10B8FB8ACF6E80" modified="2016-05-11" version="1">MSSARRAPIAATTTHIDSPDVLLVGSGIMSANLAALLKCLDPTLRIQVYEATEGLAQEASDGWNNAGTGHAGLCELSYTPTRGASGEVDVAKAISIFSDFEHSLQFWGYAAAHGMLPEPRAFINPVPHISFVHGSEWVDFLASRHRGLSRHHFFSEMQFTSDRAKIAEWAPLLLDARGDTPIAATRTPHGTDVNFGEIARGLLAWLAAQEGCAVTPSQRVTDLEKITAKPDRGRHAGKGWRVTVRDLRSGTVRHVHTRFVFVGAGGGSLPLLQKAGIAEQRGLGGFPIGGQWLVCDNPDIVARHCAKVYGQPLDTAPTMAVPHLDTRILNGKQTLLFGPFGSWTTKFLHKSGRRSDLPRSIRPHNLATLLKIGVSNLGLIRYLIQQSTQSMKDRLDVLRVFYPGARLEDWRLIDAGIRVQAIKKTDGEAGIVHYGTEVITNSDKTISALLGASPGASTSVAIVLQVLKNCFAETLSQPSARARLAEMIPSTAIDLSLPENAGEFRTLHAQALQRLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL37</accession>
    <name>A0A139SL37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_06090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712296.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06090"/>
    <dbReference type="EnsemblBacteria" id="KXU35266">
        <property type="protein sequence ID" value="KXU35266"/>
        <property type="gene ID" value="AXK12_06090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="64"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="30057" checksum="EAD6E680BD03A91E" modified="2016-05-11" version="1">MSTAAPVIATRRIIPGFGLTLGFALAYLGLVVLLPLSATFIRSADLSAAEWWAAVSSPRVVASYRLTFGVSLLAALANVVFGVIAAWVLVRYRFPGRRLVDALVDLPFALPTAVAGIALTALYAPNGWLGAPLAKIGPEGIKVAYTALGVWVALTFIGLPFVIRTVQPVLEELEPELEEAAASLGATRLQTLWRVVLPALRPSILTGFALAFARAVGEYGSVVFIAGNMPMKTEITPLLIVTKLEQYDYAGATALAVAMLVVSFALLLLINVLQLWSRRQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL40</accession>
    <name>A0A139SL40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712238.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05935"/>
    <dbReference type="EnsemblBacteria" id="KXU35237">
        <property type="protein sequence ID" value="KXU35237"/>
        <property type="gene ID" value="AXK12_05935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="317" mass="34654" checksum="B7005CA490922A24" modified="2016-05-11" version="1">MIVTTAQLFKHAYGKYAVGAYNINNAEQAMGLFQGAIDSQAPFIIQISKGARKYTDKRMLEAIIRSAGEIYPEAIFAVHLDHGDEQTCYDCIDSGFFSSVMIDASHDPFAENVAITKRVVERAHAKGISVEAELGMLGGVEEDIQVDEGNACLTDPAEAEEFVKQTGCDSLACAIGTSHGAFKFKGRQSLHFDVLEKIKGRLPNFPLVMHGSSSVPQDEVAKINAAGGTIQDSMGVDPKEYLPAAKLGVTKINIDTDGRLVWTRVHREFFRNNPEQFDFRPPGKIFMAEYAKFIASRNELLGSAGQLEDLRKSLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL42</accession>
    <name>A0A139SL42_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05835"/>
    <dbReference type="EnsemblBacteria" id="KXU35279">
        <property type="protein sequence ID" value="KXU35279"/>
        <property type="gene ID" value="AXK12_05835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="463" mass="49115" checksum="ACC2A3F965C1025A" modified="2016-05-11" version="1">MRPIFNELRTTLALAFPIIIGQLSQMLMGVADSVMVGRLGAVPLAASAFANVLFTGGFMLGLGILASGSILISRTHGAGQSRECAEYLRHGVWLAAGLGVLLAGVTFSLIPWLDHFGQPEEVLAAVRPYLELITLSLVPTLLFQVVRQFSEATGHPWGPMAILLSSVALNVLLNWILIYGNWGAPALGLAGAGWATLAARVVSLVALWAWLRAQRELRAEWPGGRRASGGRRMGSVADANPAWFARLSWAHLRAMVVLGIPIAGQLVFEGGFFAMSALMMGWIGTVPLAAHQIALNCAGVAFIIPLGLSMALSVRVSRALGEGRVKLLPSIALGAQAAGVAYAVLSVLTFVFAGRAIAGGFTPELPVVELASQLLIFAALFQVFDGGQVIASGALRGLADVKVPSVITFISYWVIGLPFAYLWGVRMGQPLAIWGSMVIGLALGGVLLVRRLYVQIRRMTRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL58</accession>
    <name>A0A139SL58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712316.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35275">
        <property type="protein sequence ID" value="KXU35275"/>
        <property type="gene ID" value="AXK12_05635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="326" mass="37084" checksum="A6F25F35F7108E7D" modified="2016-05-11" version="1">MKFAYEDLSDDQFEVLIVLLCQRLLGIAVQGFAKGPDGGRDAKFVGTAELHPSKAASWVGTVIVQAKHTNGYNRSFSELDFYSTSRSNTVVGEEVPRIKKLREAKQLDHYMLFSNRRLAGNSETEIRDHIAAECGVPASSIYLCGLEQLELWLKRFPEVAQEANLDAVDSPLIVSPDDLAEIAQALARQKDGLTALLDDPPTVRVTYEEKNALNNMTAAYAKEQRRKYLKETAQIHTFLAAPENIELLRMYESAVDEFQLKILAKRKDYQTFDEVMEYLVYLLFNRDPVLRQRAHKRLTRAILFYMYWNCDIGEVDDDATNQTLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL62</accession>
    <name>A0A139SL62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712222.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05890"/>
    <dbReference type="EnsemblBacteria" id="KXU35230">
        <property type="protein sequence ID" value="KXU35230"/>
        <property type="gene ID" value="AXK12_05890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="25919" checksum="A4CBE313AB7155EB" modified="2016-05-11" version="1">MNTILGIDIGGSALKGAPVDLVSGKLLTEREKLETADKLSPEAMAEAVAEMVRRFDWRGPVGVGFPGVVHGARIAWVANVHKGFCDCDAGALFSQASGCPVTLINDADAAGLAELRFGAGRGESNTVLVLTLGTGVGSALFHNGRLHPNTELGHIIKEGQSIECYVSAAARVRRGLDFEAWGRELSDYLIQLEKILYPDLFILGGGISREHDKFFHCLKPQARVVPAEFRNTAGIVGAALAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL70</accession>
    <name>A0A139SL70_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">AXK12_05485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712070.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05485"/>
    <dbReference type="EnsemblBacteria" id="KXU35301">
        <property type="protein sequence ID" value="KXU35301"/>
        <property type="gene ID" value="AXK12_05485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="286"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="455"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="533"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="658"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU35301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1259" mass="140257" checksum="DF064F9DFB77EFB8" modified="2016-05-11" version="1">MADRTLSERINFGKLHEVIQPPNLIEIQITSYLDFLQKGVPDKQRKPQGLEAVFREVFPIESYDGRLTLEYVSYTLGEPKNTEIGCIRDGITYSVPLYVKLRLREEDFIKDEEIYMGEIPMVTDRGSFIINGAERVVVSQLHRSPGIAFEVTPHPNGKLLHSFRIIPDRGTWLEVQFDNSDLLYVYLDRRRRRRKFLITTLLRAVGYSSDIDILNLFYEIKSLKVSKALEMENVSTLVLVEDAIDAQKGVVLARAFEPLTKQIVRTFEKHDIETIRVIDTANDEGAIIRALKKDPTRNEEEALKEIYKRLRPGEPPTTANAKALLKRLFFDPKRYDLGRVGRYKVNQKLGLKVELEQRILESGDVVGATKYLVRLKRGEGVVDDIDHLGSRRVRTVGELLANQCRLGLSRTERLVRERMTMYDQSVDSITPQKLINPKALTTVIRDFFARSQLSQFMDQINPLAEVTHKRRLSALGPGGLNRDRAGFEVRDVHPSHYGRICPIETPEGPNIGLINSLSTYARVNEFGFIETPYRVVKGGRATDEIDYLTADQEEAKVIAQANAEIDAKGNFVGKVTVRKDGEFLEVPASEVDYMDVSPKQVISIAAGMIPFLEHDDANRALMGANMQRQGVPLLQAESPFVGTGIEERVARDSKIVVVAEAAGTVASVDANRIVITKDGELPRTLKTDAKSGTYVYELRKFMRSNAGTCFNQKPLVRIGDKVKADQIIADGPSTEKGEIALGRNVLVAFMPWNGYNFEDAILISEKVLKEDIFTSIHIQEFEVAARDTKLGPEEITRDIPNVGEEALKNLDHNGVIRVGAEVKPGDILVGKITPKSETELAPEEKLLRAIFGEKAADVKDTSLIVPSGAAGIVMDVKVSSRIDNEIERLSPSDRRRQAKQIQEEFKTQMDKLREGLTEALSNILLGEKIPLDVSNGDTGEIIIPANRKITKTLLRKLAAVAKHVEIDPSPVRIKIMEIIGSFQVKFDELEGDRDRKVAAIEAGEGDGTGSIKQVKVYIATKHKLEVGDKMAGRHGNKGVVAKIVPEEDMPFLPDGTPVQICLNPLGVPSRMNVGQVLETHLGWACKKLGIKVATPVFDGIPEKRVREYLKEAGLPTSSKSVLYDGRTGEQIDQQVVVGYIYMMKLNHLVSHKIHARAVGPYSLVTQQPLGGKAQYGGQRYGEMEVWALEAYGAAHTLQELLTVKSDDVQGRTKIYESLVKGDNTLQAGTPESFNVLIKEIQSLGLDIKLNKRDSLGFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL76</accession>
    <name>A0A139SL76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712230.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35234">
        <property type="protein sequence ID" value="KXU35234"/>
        <property type="gene ID" value="AXK12_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="404" mass="43640" checksum="2AE5B4E5D28C39D1" modified="2016-05-11" version="1">MPSPDLKLGLIGSAGRGASLGTLAHRPSKGARIVACCDVATHALDEARAAYTHKGTPPFTTRDYRELIALADSAALDAVIIATPDYLHETHAVAALERGLAVYLEKPMALTIAGCDRILATAKAHRARLYLGHNMRHMGFVRKMKALIDAGAIGEVKACWCRHFVGHGGDFYFRDWHADRRYSNSLLLQKAAHDIDIIHWLCGGYTRLVNALGGLTLYGDLPERAPATKGPPPGIALRGMDFTTFPPTRQRGLNHRIDVEDLSTMQMRLSNGVYATYAQCHYTPDYWRSYTIIGSEGRLENFGNGGAGTVVRLWNKRSGYNAAGDASYKIPTTRGSHGGADPLIIAEFLRYVREGGTTDTSPLAARESIAAGCLATESLRSGGIPLKVPPPNAALARFFENGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL85</accession>
    <name>A0A139SL85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712265.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06000"/>
    <dbReference type="EnsemblBacteria" id="KXU35250">
        <property type="protein sequence ID" value="KXU35250"/>
        <property type="gene ID" value="AXK12_06000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="246" mass="28382" checksum="BA0470936BA61C20" modified="2016-05-11" version="1">MELKEYANMDRVEKAHWYNVGKREFVRRWIAKVRPPNKDDVLLDCGAGTGLFAKEMEAYCQVLALDALEPALELLRQRFRPDQVIAMTGKDIPLPGDSVNYLTALDVVEHIEDDVTAVRGFHRVLKPGGVAVITVPASMLLWSEWDVSLHHYRRYNRRGLLALFPKSDWEILHSNYTNSLAFLPALLLRKLRGRKPQTEKEESRTEFRIPPSWLNKLLKWIFVKTAMSRFPMPFGLSLILVARKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLA2</accession>
    <name>A0A139SLA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712292.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06080"/>
    <dbReference type="EnsemblBacteria" id="KXU35264">
        <property type="protein sequence ID" value="KXU35264"/>
        <property type="gene ID" value="AXK12_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="27941" checksum="B91838CC654BAAD4" modified="2016-05-11" version="1">MTTLKTALVTGASRGIGRGVAIELGRAGYRVAINYAGNVAAADEALALVRAAGGDGVTVQADIASAADRERLVEEASAGLGGRIDLLVNNAGVAPTLRADLLEAGEESFDRLYAINLKGPFFLTQRVAKQMLAQEADAEGFRGRIVNVTSISAYTASTSRGDYCMLKAGLAMMTTLFADRLAADGINVYEIRPGIIATDMTSAVKDKYDQLILRDERGITPIRRWGRPEDIGRAVRAIAEDRFPFSTGAVFDVDGGFHLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF5</accession>
    <name>A0A139SLF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711957.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05210"/>
    <dbReference type="EnsemblBacteria" id="KXU35372">
        <property type="protein sequence ID" value="KXU35372"/>
        <property type="gene ID" value="AXK12_05210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="4">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="376" mass="38872" checksum="6BF48396191BE309" modified="2016-05-11" version="1">MTSDDIKAQLAQVKYPGFSRDIVSFGLVRSAAFLEESGTAKVSLALTTSDPQMPLQIKTAVEAQLRGLPGVREVIVDLAVTSVKPPVTGGASGTAGVGGNLAGGAALPEGMAHAVAIASGKGGVGKSTFAVNLACAAAQVIAASQGRLWGRQRSPRVGLMDCDIYGPSVPLMMGLSGRPEIEGDGAGAMIIPMVHHGVKVMSMGFLVDDNTPVIWRGPMIMKTVQQFIQNVKWGELDLLLIDLPPGTGDAQLSLVQTIPLDGAILVTTPQAAATQVARKGGLMFQKVNVPLLGVAENMSDFVDSSGQHHALFGSGGGAATAEQLGTVLLGKVPLLSAIREGGDLGQPIVVREPQSETAQLFRDMAEGLLKGLKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLI4</accession>
    <name>A0A139SLI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="4">GluTR</shortName>
            <ecNumber evidence="4">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemA</name>
        <name evidence="11" type="ORF">AXK12_05385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712013.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05385"/>
    <dbReference type="EnsemblBacteria" id="KXU35402">
        <property type="protein sequence ID" value="KXU35402"/>
        <property type="gene ID" value="AXK12_05385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="10">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="9">
        <location>
            <begin position="187"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4 6">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4 6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="4 8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="362" mass="39613" checksum="05C00002F20EC0F9" modified="2016-05-11" version="1">MTLVATPPQPSLAATVQQTLFVLGATHHRTPIQVREKLSLDPGALAALHETLSTIEGLDEFTMLSTCNRTEFYGVASSADTVPRLRRAFCERQNFSETEFTRYALQLEGPRALQHLFEVASGLDSQLVGETEIFGQLKDAYAAAHARRSTGPILNRVFQKAFQAAKHVRTHTAITEGQVSVANVAVELARDIFGQLNRTRVLLLGAGEIGEKTAKAFQSRGVTSLSVSSRRLGRAMELASELRAFALPFWLAPAKLPEFDIVVCATAAPSTVVATAAVAAAMHRRAAQPLFLIDLALPRDVEPPVADLPNVYLYNLDDLATIAEANRHSREAEVAKCRELLRNRSETLWSHLRPRLESRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLP1</accession>
    <name>A0A139SLP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712015.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05395"/>
    <dbReference type="EnsemblBacteria" id="KXU35404">
        <property type="protein sequence ID" value="KXU35404"/>
        <property type="gene ID" value="AXK12_05395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="366" mass="40801" checksum="5CEA58EF402816D3" modified="2016-05-11" version="1">MQKVFQIGPRSFALDQAKAEQVFMGKRVINGYETMTFNLLPLKYQWAYDLYRTMKANHWDAEEHAMARDVAHWRDVRVVSDAERDIVRLGVGYFAAAEAFDGYAVRYATRELVTAPELKLVLGRHTHEENVHTDSLVHMTGGLGLNPHTCEARFRAACAAGRPAPQLSEQISPDFHRGLDLTLHENKQLFAKTIFLFSQCVEGTKFFGLHALVLSLYAQGKFPAVGQIFRNTLRDEAQHIEFFRNLFLELIKENGELWTEAFREELRGLMATAIAEEKRFVRDGLGADAVAAAGLRLDDLLTYLDTVGDRRLEGCNLASLSAGGGAKAQNPLPWLDELLGLAAAADGGSHDYQKTASLNQSSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLT2</accession>
    <name>A0A139SLT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05145"/>
    <dbReference type="EnsemblBacteria" id="KXU35508">
        <property type="protein sequence ID" value="KXU35508"/>
        <property type="gene ID" value="AXK12_05145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="84"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="384"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="656" mass="70628" checksum="9A204B753323F3BD" modified="2016-05-11" version="1" fragment="single">MIVVAVPRRSLAAARYAYTQTDHDTMPRFRLSLLVLSGALALAQLPAATRAADATETRPLGDDAPLALERVVVSTSPLARTLGEVSQPVSLLEGHRLAQHQSPTLGELLSGEPGIASTYFGPGASRPIVRGIGGDRLKVLENHIGTIDASATSPDHAVSLDPLLVERVEVVRGPAALLYGGNAIGGVVNVITGRIPSALPNSPITGRVEARSHSANREESAGAVIEGAAGDFAWHIDGFLRDTKDLKIPHFAESQRKRIADGSDPAEADYRRVPNTEIESDGGSVGLSWIRESGYIGIAWSGFNSLYGVPGHAHSHGDHDHHSHGHDEDDDDHDDHDDHDHGDEAHEDEAVKIDLVQRRFDLAGEINRELGLLRGAKFALGFADYRHQELADGEVDTVFKNRGYDARLELLHREIAGTNGALGWHGSESRFEAIGAEAFVPPSRTTNHALFILEEKPIGPVALQLGGRLESQKIKLRNGSGRSRKDLLASVSAGALWKLSEDWSLGLAASRNERGPGAQERYANGPHIGTRAYEIGSPHLSIETSTALDLTLRKRTGRVTGALTGFVNRFDGYVFEQPTGQVAIAHGDHFHFEPDTHPDAAEGLTIYRYAQTDARFLGLEAELSAHLYEGSLGRLDLHLATDAVRGKNLKDGGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM87</accession>
    <name>A0A139SM87_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_04705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04705"/>
    <dbReference type="EnsemblBacteria" id="KXU35693">
        <property type="protein sequence ID" value="KXU35693"/>
        <property type="gene ID" value="AXK12_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="65"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="205" mass="22694" checksum="2157AAE99DAC57B7" modified="2016-05-11" version="1">MISPEGKQLGVLPTATAISLALEVGLELVEVAPAARPPVCRIMDFGKYVYEESKKTSHAKVTASKIKEIELTPRIEQHDFETKIRHAEEFLSHGSKVKLRLKFRGREMARTELGFDVIRRAIADLEGMGHPDSEPRLIGRNINMMITPLPENKRKPKYYHPHHHEAAAEDDEPRAHAKKAESAHAEDSANEAASAQPAPAAGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM90</accession>
    <name>A0A139SM90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ethanolamine utilization protein EutJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_04795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711789.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04795"/>
    <dbReference type="EnsemblBacteria" id="KXU35687">
        <property type="protein sequence ID" value="KXU35687"/>
        <property type="gene ID" value="AXK12_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="57"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="408" mass="42619" checksum="403E5F7911CBADB5" modified="2016-05-11" version="1">MQSYSLRAHSHPLVSADSPRAMNPLPLSSSLAALATAALLSLTGCAPSRSSDAASGEIRVGEISSITGKEAACGQSTHRGIVLAIEEANARGGLLGGRPLRLITEDNQSKAGDSGTAARKLISRDEVIAILGEVASNRSLEIASIAQRSQTPMISPGSTAESVTEAGDYIFRVCFLDAFQGKVMAKFARESLALNRIATLSSVSSAYSVGLANHFKETFVAGGASIAAEQKFAEGDKDFRAQLTAIRASQADAIYIPAYYTETALICKQARELGLTLPLLGGDGWASPKLLEIGGEAVEGIYYSAPYSSESTAAQALAFIAKYRERWDGETPDAFAALGYDAALLLIDSLERAGTTEPAALRDAIASTRGLLGATGRTDIDENGNALKAATIMTVKDGKFSYVGVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMS8</accession>
    <name>A0A139SMS8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711734.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35845">
        <property type="protein sequence ID" value="KXU35845"/>
        <property type="gene ID" value="AXK12_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="472" mass="52099" checksum="588E6BA3DBBCA821" modified="2016-05-11" version="1">MKQPAAVDFAGLKAAFAAQPLFEDKSWQLSPEAWPLSPDQVADLEQIGAACLEFHHALEKLYLRSASGKSLLRNHSLHAPWVVDYLERGKPAQLVEHARDPRNAGAFPTVLRPDLLLTDEGFVMTELDSVPGGIGLTAFLNRLYAGASGSGREILGSGDQMISAFYDSLAALRPELPSPRIALVVSDESATYRPEMQWLAEQLQLAGKQVVCLSPREIFPLENALFYDVGGTPEKLDILYRFFELFDLPNIPTAPYIFEAWAAGEVAIAPPMRSFQEEKLGLALFHHHRLADYWREALSKRAHKVLTKLIPESWILDPAPLPPGAVLDGPLAAGRPISDWRELANASQKERDLILKVSGYHETAWGARSVTLGADSSREEWAAALDRALDLAPTHPHVLQRYKKPRRVSHPVYEANGDLRADAQGRLRLCPYYFVKSGQATLSGALATFCPPDKKIIHGMQDAALLPCRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN35</accession>
    <name>A0A139SN35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ORF">AXK12_04165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711524.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04165"/>
    <dbReference type="EnsemblBacteria" id="KXU36026">
        <property type="protein sequence ID" value="KXU36026"/>
        <property type="gene ID" value="AXK12_04165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="724"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1309" mass="143706" checksum="80850329CB13FA0E" modified="2016-05-11" version="1">MYLKALKLHGFKSFSDPTTLNLEPGVTAVVGPNGCGKSNIADAIRWVLGEQSAKALRGGKMQDVIFEGSDARKAAQLCEVSLLLTDCEKQLGSEFHEIEIMRRVHRDGASEYFFNGRACRLKDIHKLFMDTGVGRMSYSIMAQGQIDQILSSKPEERRAVFEEAAGITKYKAQRREALGKLALTDQNLSRVADVVGEVSRQIGSLRRQAAKALRYKRLNHRMRHLALAWNSHQHAALSATLGELDVQVTALRAQADTRRRELESQQGSLDEKKAARAQLNQRVQDAQQAAYDLRSQKEAAENQANLAQTKRSGLEDRLTGSRNTLGELEMQLREVSEQADTGAQDKQQQLTLLGSSDDVFQQCNRELGIVEGELSKVEEQLRQAKFALLQTESSVTRLRADCSRYEVDQKTSAHRHETLAAELAQAREQSASSTQRVAELDTRVAEASTEKTKATESVAAAQQRIAALTSEFREAQRKQQEIDRALAQRSARLRLLQQLQEKWEGFGEGAKAILQGRLNKAFTRAGEGPQGSDVTGETEQNAEAEKPLPITQGLEVRPAHARAIEALLGAAAEAIRVSDTATAQRVLAQLEAESLGAAVLHVGDFKGRGDDVASQNKTACDCIKAASEALIAPEPGHPALSILSACYITDDLPAFLDYWKANPEFSFLAVASAKGELVDRRGLIYGGTSKKPANSIVQREIDLRETAKALAEEQKAHDAQKAVIEKIAASLAEAEAALEQARSAVLAATQQLAQAQAEQRSATQASEEVARRIERMTRELGSLEQASREAQLRWEKAQAALAEAEAAVQSQRDTIQSAEARSFEVRTSRDAKREALAQARLDLAEHRQKVEVLDRGLGEMQRRRQQLEAVLKQRRDEIGFCTTQIADLEKEAATAQVRAKDLEASLATAQQQVETLRVELVELERVISQIEGTQHSERQQADAAQSELGRHEVKLAELRQRVAFLVEEVQREFSIEIGEVDWRLSLWRADDEPEGIQALDLDEEDEGGQPSEAATPQSSEAAAETEPEGEGSEAASGAAAAVAPKRRRKKKEQRGEPTEADLAALDATDWAAVKHEADALRQRLGSLGAVNLVAIEEYAELKERHDFLKKQVADLSSAKAELLGAIDEINQTSRQQFELTFEQIRKNFAGTFQTLFGGGRAELELIETDDILESGIEIVAQPPGTKLKSITLLSGGQKTLTAVALLFALYMVKPSPFCLLDELDAPLDESNIGRFTTLLKQFVDNSQFIIITHNKRTVSAAQAIYGVTMEERGVSKIVSMRFSHHPHSDGDSPQPANIAEAVVAARAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN42</accession>
    <name>A0A139SN42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Xylose isomerase</fullName>
            <ecNumber evidence="2 9 10">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xylA</name>
        <name evidence="13" type="ORF">AXK12_04605</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711694.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04605"/>
    <dbReference type="EnsemblBacteria" id="KXU35967">
        <property type="protein sequence ID" value="KXU35967"/>
        <property type="gene ID" value="AXK12_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="132"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU35967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="455" mass="50539" checksum="3D4724EB7878CB9F" modified="2016-05-11" version="1">MSAKKNTRPARAKTAAARAHFPKIDKITYEGPESDNPLAFRHYDPTEEFDGKPLSEHLRFSVAYWHSFCGTGADPFGRGTIVRKWDEGKDEVSIAKNRMDAAFEFFQKIQSPFWAFHDRDIAPEGRTLAQSHKNLDALVAHAKKLQKATGVKLLWGTANLFGNPRYMSGAATNPDAHVFAYAAAQVKKAMEVTQELGGENYVFWGGREGYETLLNTDLKREQEHLARFLHMAVDHAKAIGFKGQFLIEPKPKEPTKHQYDFDVASGIAFLRTFGLEKHFKFNIETNHATLAGHTFSHEIEVAAAQGMLGSIDANAGDTLLGWDTDQFNTDIRELTLAMVSILRAGGLGSGGLNFDAKLRRQSIDLEDLFHAHIGGMDAYALAFKIARDILADGQLDGFVADRYASFDEGYGKEIETGKATFKSLEKLVLTKLGEPKPRSGKQELLENLITSYIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN85</accession>
    <name>A0A139SN85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711522.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04160"/>
    <dbReference type="EnsemblBacteria" id="KXU36025">
        <property type="protein sequence ID" value="KXU36025"/>
        <property type="gene ID" value="AXK12_04160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="579" mass="63492" checksum="5221A2E28B2E7EAC" modified="2016-05-11" version="1">MFDERSQELFEILNADQGARTSDGGGVGIDREKLKESWEVHQATGQPLADIVLARGLITRDGLLVAVAKGLGFQFSKIAQSEFSPELLGALSPELARGYGAFPHHAESHLLEVWATDPFNTQVVDDLGFALGKEVRLVVADPDEVRKLVERCYGEGASSLEDLLTSIDIRHYEQGAAAETDLAERDLEAMAGQAPIIHFVNLVLTQAIRDKASDIHFEPFEHEFRIRYRIDGALYEMTPPPRQLALPIASRLKVMANLNIAERRVAQDGRIQFTLAGQGARTVDLRVSTLPTQFGESIVLRVLDRAAVQLDLSQLGLPIRIHDALSEIIRRPNGILIVTGPTGSGKTTTLYAALRTINTTEAKLLSVEDPVEYEIDGIMQVPVNAPIGLTFASALRAFLRQDPDVIMVGEIRDLATAQVAIQAALTGHLVFSTLHTNDAAGAITRLVDMGVEPFLISSTVSAVLAQRLLRRICPHCKTSYQPSTELLASEGIDPRAVAGRPFYRGRGCSHCHNTGYLGRLGIFEWLPMSEEICEQVLMREPTLVLHKTAIAQGMFTLREDGLRAALDGETTLDELLRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN98</accession>
    <name>A0A139SN98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711590.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04355"/>
    <dbReference type="EnsemblBacteria" id="KXU36058">
        <property type="protein sequence ID" value="KXU36058"/>
        <property type="gene ID" value="AXK12_04355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="404"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="618" mass="68821" checksum="5C5868D7BBC312B9" modified="2016-05-11" version="1">MANAYTEASIKTLSSTEHIRLRPGMYIGRLGNGAHAEDGIYVLLKETIDNSVDEFAMGNGKRIEIELSEREVIVRDYGRGIPLGKLVECVSVINTGAKYDSQTFQKSVGLNGVGQKAVNALSLSYTAQSIRDGQTKIVEFAQGRLVKEGKVAHCSERSGTLIRFTPDAALFGADWRFRPEFIEDLLWNYAFLNRGLTLTLNGRAFRSAGGLRDLLEKNLTVETLYPIIHLEGPDIEIAMTHGAHYGEEYYSFVNGQHTTMGGTHQLAFREAVVNTLRNFYKKDFEAADIRQAIVAAVSVRVQEPVFESQTKTKLGSTEVGPGGPTIKEFIGKFVQQTLDVYLHKNKATADALLAKIQESERERKDLAGIRNLARQRAKKASLHNRKLRDCRQHLGTRAALAEQSTLFIVEGDSAAGSLTACRDVQTQAVFALKGKPLNTYGLSKKVIYENEEFHLLQSALNIEDGLDGLRYNRVVIATDADVDGMHIRLLLISFFLQFFPEVIAAGHLYILETPLFRVRNKRRTIYCYSETEKQAASAALGAGHEITRFKGLGEISASEFKDFIGENIRLEPVSLAHLHDSEELLGFYMGKNTPRRQEFIIDNLRVEKDLVETLSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE1</accession>
    <name>A0A139SNE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_04475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711632.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04475"/>
    <dbReference type="EnsemblBacteria" id="KXU36079">
        <property type="protein sequence ID" value="KXU36079"/>
        <property type="gene ID" value="AXK12_04475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="97"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="23045" checksum="E4BA8959E6B28BA4" modified="2016-05-11" version="1">MAYTLKPLPYAHDALEPHIDARTMEIHHGKHHQAYVNNLNAALESAGVTPPSCLCNLISNLDKLPESIRGAVRNNGGGVANHNLFWKIMGPGKGGAPTGALATAIDATFGSFDKFKEEFAKAGATRFGSGWAWLYVTPEKKLAVGSTANQDSPRMGKAIAGIEGTPILAMDVWEHAYYLNYQNRRPDYIAAFWNVVNWDAVAERYTDALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF9</accession>
    <name>A0A139SNF9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711515.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04145"/>
    <dbReference type="EnsemblBacteria" id="KXU36022">
        <property type="protein sequence ID" value="KXU36022"/>
        <property type="gene ID" value="AXK12_04145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="178"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="353" mass="38567" checksum="D985818FC560A3CC" modified="2016-05-11" version="1">MSAETTTPTALLSVSRLKDYIEADRGRTFVSLLIARRVTHKTAANGNPFWSLELGDRSGSFRCTLFGDSPVCASLSPALEGSALRFEGKVDFYQGTFSPRPTHITPLSEAELAALPPDALDELIEKAPEEAAQLRAEFEDFIKKISHDELRMTLRQVFDAIGEAFYACPAAIAMHHAYRHGLLEHTVHMARVARATLPLYPEVDPDLAMAGILVHDIGKVIEYEGTLAAHRSRRGVLQGHVVLGYQLVRRAGLKAGLDEDRLERLEHIVLSHQGAPEWGAAVYAATPEAVFVSMIDNLDARMGMVQRALRQASDQSEFSERIPGLNTTLLTAPIGGAPPTPSQRESLLTPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNI7</accession>
    <name>A0A139SNI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711594.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36060">
        <property type="protein sequence ID" value="KXU36060"/>
        <property type="gene ID" value="AXK12_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="102" mass="10876" checksum="D1AF526519C9CF3E" modified="2016-05-11" version="1">MHPATATTPFTLLWASIARNEEDPPQRSLAPAPRALAQQTSRAPMPTAAPKGSSSQSITRATAQPTDARARSVSTPARNERAADAFIPADFLVTNLRPDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNK8</accession>
    <name>A0A139SNK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-Hacid_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711602.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04385"/>
    <dbReference type="EnsemblBacteria" id="KXU36064">
        <property type="protein sequence ID" value="KXU36064"/>
        <property type="gene ID" value="AXK12_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="36933" checksum="C694D4C35F637C4B" modified="2016-05-11" version="1">MTAKPPAVLLLAPYSLNLAYGGPVLDRLRATVDLRAIITPGDTWREHRAALAEAQVLFSSWGMPVLDTELLDALPQLRAIFYAAGSVRSFVTDAMWARGIRLSAASAQNAIPVAEYATAALILGLKHFWHYPRGLYAAHSTHLEKPPAPTPYRSTIGLISYGKIARLVRQRLRTYDVSVAIYDPFLSAEEAQRESVRKVDTLDELFATADALSLHTPLLPETEGMLQARHFEAMRPGAFFLNTARGALIDEPAMIEVFRRRTDLTAVLDVTYPEPPAPASPLFTLPNIILTPHLAGSVGPECQRMGDAMIDEFLRYRAEAPLHWELNAAQAELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM9</accession>
    <name>A0A139SNM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711674.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04185"/>
    <dbReference type="EnsemblBacteria" id="KXU36102">
        <property type="protein sequence ID" value="KXU36102"/>
        <property type="gene ID" value="AXK12_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="451" mass="48489" checksum="6386BE1305D2D9E0" modified="2016-05-11" version="1">MEHLDSTILNTAIPAMAQSLHVAPLALRSVSTSYMLALAVFIPISGWMADRFGTRRVFFAAVGLFALGSLVCGLSLNVQMLVAARILQGMGGAMMTPVGRVALVRTFPRSDLLRTMNYVIVPALVGPMVGPLIGGLIVHWLHWRIIFFLNLPLAIFGLWLVHRTMPNYLESDTPPLDRTGFLLFGAGIALLSYALQVFGEHTMATAPLSLLTALSLLLLALYGWHSRRVENPVLALWLLRARTLQVSVIAGGVSRLGIGGMPFLLPLLYQIGLGFTPWEAGLLMMPNAVAAILMKISSGRVLARLGHRTTLISNTAIVGLTIGCFSLVGPGVSVWALAALSFVQGFFISLQFTSINSLVYAEVEDRDAAKASSIASTAQQLTFSFGTALAALLAGWFLSGLDQTNPAQILPALHRVFLTMGILTILSSLCYLRLRPSDGSNISGHGQGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP1</accession>
    <name>A0A139SNP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36178">
        <property type="protein sequence ID" value="KXU36178"/>
        <property type="gene ID" value="AXK12_03960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="75" mass="8178" checksum="1A5FDCDCBAF2FF1D" modified="2016-05-11" version="1">MSPKREAAVCALDDSATQGSQAFGRKDPKLGGGSLLVIFPTSPKRVITLLSLLLLSLSQRDRGECFQIWDFVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR5</accession>
    <name>A0A139SNR5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36219">
        <property type="protein sequence ID" value="KXU36219"/>
        <property type="gene ID" value="AXK12_03515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="93" mass="11245" checksum="DC861B690D10F40F" modified="2016-05-11" version="1">MRRYTVRLELDDAQRDQLHPIVVNAEGELRELRNRSFQDAIAIGDRMNAQVALLLRPDQHENFEKLKEAVRNYWERERERRLSKSEESRKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP03</accession>
    <name>A0A139SP03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711358.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03720"/>
    <dbReference type="EnsemblBacteria" id="KXU36252">
        <property type="protein sequence ID" value="KXU36252"/>
        <property type="gene ID" value="AXK12_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299387" evidence="2">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="130" mass="14382" checksum="ECB96F7E915C0325" modified="2016-05-11" version="1">MIGCLKIALALAFLSAVADRFGLWGAPGSEGVFWGNFENFVAYTRLINPWFPKVLAAPISYFITGLEIALAILLFTKWKTKEVAFISGLLLLTFAVAMTFSLGPKSAFDYNVFTAAFAAFALYCLLRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP95</accession>
    <name>A0A139SP95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">AXK12_03390</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711252.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03390"/>
    <dbReference type="EnsemblBacteria" id="KXU36342">
        <property type="protein sequence ID" value="KXU36342"/>
        <property type="gene ID" value="AXK12_03390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1216"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1585"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1362"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1570"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1931"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="1623"/>
            <end position="1630"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1951" mass="213184" checksum="73BF520079D41C0E" modified="2016-05-11" version="1">MPASRKPSSPNNRPDAIRLRGVRQNNLKGFDLDLPLGSYIAVTGLSGSGKSSLVFDTLHAEGQRRYVETFSAYTRQFLELLPAPKVDAIDNIRPSIAIEQTNTVKTSRSTVGTMTELCDYLKVWFAQNARCYDPDTDEEIEDDTPDTIWRKTLTAAEGHTLLLCFAVTRPPQLTWAEILQNLKTQGYLRILVSEPVPQIFKIDDLLALPPEALARQLPADSPASIQVVQDRLKMRADGRARFLEAAETALHFGQGQLQLFEHSQPGHAEQTFAPVATYSRGLHSPTTGRQFRAATPALFSFNSPLGACPRCRGFGRVIEIDYRLAVPDHSLSIEAGAIKCWESDIYGESKKDLLRVARRLKIPTRIPFSQLTPEQRDLVINGEPDYDDAAGRTWPDYWYGLKGFFDWLEKNAYKMHVRVFLSRYRSYNTCPECHGARLQPEALCWRWQGKTLPQLYQLPVCELLALLDQSAPATSSQSDVLASILTRLRYLEQVGLGYLTLDRSSRTLSGGEAQRVTLTSCLGASLIDTLFVLDEPSVGLHPRDIDRLIGIIRTLTNAGNTVVVVEHDEAMIRAADYVVEIGPEAGSAGGHLVFQGSVAQLLAAPQSLTGAYFSGRKKIETPTARRPVTAETPALHITGATKHNLRDLSLTIPLRRFVALSGVSGSGKSTLLNHVLYQGLLDQRGQYPATPLTSLSDASPTNAPAARSDAPIKGVCRSDLPLGEIVLVDQSPLTRTPRSNPALYCEAWDDIRSLYAATPTAQAAGLTASSFSFNSGDGRCDHCQGRGYEKVEMQFLSDVFVPCPVCEGRRFKPEILKIRWREKSVADLLDLSINAALPLFTDHPKIAEKLRGLESVGLGYLTLGQPLNTLSGGEAQRLKLLKYLSAHVGINESAPHAAGALLLLDEPTTGLHPHDIKRLLDVLQTLVAQGHSIVVIEHNLDVLKSADWLIEIGPEAGSAGGQIVATGTPEQLATGDTATSPFLRQALSPKKAKPKMLHATTAQATHSKTGETTLTGARENNLKNLSLTLPHRTLSVVTGVSGSGKSTLAFDILFAEGQRRFMESMSPYARQFVEQLPKPAIDSLSGIPPTVAIEQRVTRGSRKSTVATITEVAQYLRLLYARLGVQHHPETDRPVTPLRPDELRALLSRQLAAPETQRAKHLYLCAPLIRGRKGHHQPIATWIAKQGYPLMRVDGRVLATESFEKLDRYREHDIEVVIADLKTVTESEAHAALDKALQLGKGTCFIVSTGSTRSAKETVLAYLSATRTDAATGESFPELDPKHFSFNSPRGWCPTCRGHGVVYPWMLEKSDGEDADDPLARLRSFGIESGEDLSDDGQPCPDCHGERLARIPRAVKLHFKARNPERTDSPHTGPQPQPILGDGGATPHRKIKESAPPLSLPALLRLSSAELLAALRDLDLDSRGQLIAQDIIPQIEERLKFLDEVGLGYLSLDRPTETLSGGEAQRIRLAAQLGSNLSGVLYVLDEPSIGLHARDNDALIATLQRLRAKNNTLLVVEHDDALMEHADHIIDLGPGAGLHGGELLASGTPAQIKRSAKSLTGLFLKNGIPHPTRGSYRELPPAPTPRTKKTEARPWLELRGATLRNLRDVDLRLPLGRLIMVAGPSGAGKSTLFRDILHPAVSEAIKTQKAKLAPRRRSGKNTAPPSFGELVNGHVFKSVIEVDQSPIGKTPRSTPATYLGIFDLIRQFFASLPEAKLRGYTASRFSFNTAGGRCETCAGAGRIKLEMAFMPTTYLPCEDCGGSRYARELSEIKWKGKSISEVLQMSFEEAAAFFDFHSRLSEVCQLMVDCGLGYLSLGQSSPTLSGGEAQRLKLVTELARGLSSFKEKSKGLRPQNLYLLEEPSIGLHLSDCERLIGVLQKLVDQGHSVVVIEHHLDLLAEADYLVELGPGGGPHGGQILYQGPLCGLLDNPSATPKSPTAPYLRQKLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPI2</accession>
    <name>A0A139SPI2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000025">
        <property type="protein sequence ID" value="KXU36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711237.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03305"/>
    <dbReference type="EnsemblBacteria" id="KXU36456">
        <property type="protein sequence ID" value="KXU36456"/>
        <property type="gene ID" value="AXK12_03305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="277"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="736" mass="82350" checksum="7A6510C9553FAD4C" modified="2016-05-11" version="1">MLSLAVATYAQQTPAQNDEEIVRLSPFSVSESADIGRYQAAEASSGTRVRMNLMDSTQSISVVTSEFMQDIGTARLTDAIKYVAGLSNQGGFPLLMDVMNVRGFSDYDLTLDGFAQFSLANQDPIIVERIEFVKGPNAILAPQGLPGGVVNNISKKPLFTNKGYLSYQVGRYDSNRAELDANYVVNDKLAVRVVGAFTDADDYGQRVFHQNTTAMPMFTYRLSPTTEFTLQFQVQKADILAAGRAPLSLYAVGRNNIHLSEGLPRDFQHVGRNITAHQKSHNTRFQLSAQITDKLSMRVAGNWVESDVRSNFLGSSAPYLGQTGVVVDPIQLNPITGEWYWDGTFNDNPTYKLGGLKEWPVRMRGNFQNDFVYEHTAANWKSQTVAGYAFNYISQHFRQTNYADDGIYYDFANNYTPPAYAFDPDIDWHFNSSDRHRGNQVYIYEVINLFDDRLVLSGSLSQNRYASNVYNNQTGVRIDSRAEATLPSAGFVYKMTPGVSVFYGYSKQEVLVGGDPGLGIPAHTRPGRQHEGGLRLRLFDGRLYATATYFDILQENLWRDNPENNRVPIPFPLKPAVNTSVSSKGVEFELAWAPNENFSLIGSYTNFKFRDDENMRGPNVAEETAAMWASYTFTQGALSGLRVGLGANYVGERAGDAEGRWTSPPAGYDPVRVQPVFWMPSYIVAEASASYRFNKNWQAQLSIHNLLDKDYITGSELRRVFVSTPINPKLTLRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPM1</accession>
    <name>A0A139SPM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711234.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03200"/>
    <dbReference type="EnsemblBacteria" id="KXU36483">
        <property type="protein sequence ID" value="KXU36483"/>
        <property type="gene ID" value="AXK12_03200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="231" mass="24641" checksum="16A8062D1932989C" modified="2016-05-11" version="1">MREAHGLFVVEGEKVVSELLAANFALEALYVTPAWTGPRNHPQFHELNPAEMARVSHFPTPSSALAVGRIHRPPLPEAALHSGLSLVLDRIQDPGNVGTLLRLADWYGLARVILSPDCADLFSQKVINASKGSFARVLCYTTPLAPLLATTRQAAPTVPILGCDLEGDNVHTTQPLHDGVIIIGSEGRGLSPELRPHLTGVITIPRYGAAESLNAALAAAIICDRLALPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ64</accession>
    <name>A0A139SQ64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DFP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711142.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02815"/>
    <dbReference type="EnsemblBacteria" id="KXU36706">
        <property type="protein sequence ID" value="KXU36706"/>
        <property type="gene ID" value="AXK12_02815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="219" mass="22738" checksum="5748138F3DF9AC31" modified="2016-05-11" version="1">MRILVTAGGTREPIDRVRAITNTSTGATGAALAAALTALGHSVELLRSAHSIAPSPSLASQAFTTTASLEAALRERLGTGDIDAVLMAAAVADFRPAEPLLGKIDSEAAALTLRLVRVPKLLPQLHAMSPRPLRVIGFKLTVGASDAERLAAVTAQFRAARVDAIAHNDLSEIETATARGTPHPFRLYTRAANDQAPPRLAGPAALAAAIHAFLTQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ83</accession>
    <name>A0A139SQ83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711208.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03165"/>
    <dbReference type="EnsemblBacteria" id="KXU36621">
        <property type="protein sequence ID" value="KXU36621"/>
        <property type="gene ID" value="AXK12_03165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="352" mass="38067" checksum="2CE2ED63CB7E0820" modified="2016-05-11" version="1">MQTTTDLNVTETRPLPTPAELITETPASDALARFVAQTRHDLHRILFTDDRRFLLVIGPCSIHDLEAGRDYARRLAALAPKVADRIMIIMRVYFEKPRTTVGWKGLIMDPHLDGSHDIEAGLRSARAFLREVLELGLPTATELLDPITPQYIADLVCWAAIGARTTESQTHRQMASGLSMPLGFKNGTDGTLRAAINAILAAAQPQTFLGINRSGAASAVRTRGNPDCHLVLRGGSAGPNYSPEHIASAEATLAKAGLPPTAILVDCSHDNSAKKPQLQPEVLRALLAQIASGNRSIMGAMIESNLEAGSQPFPQPKDKLRYGVSITDGCIDWATTEALIHELYEGLAPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQB3</accession>
    <name>A0A139SQB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711192.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02940"/>
    <dbReference type="EnsemblBacteria" id="KXU36728">
        <property type="protein sequence ID" value="KXU36728"/>
        <property type="gene ID" value="AXK12_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="344" mass="36744" checksum="918CAA1AF53581E4" modified="2016-05-11" version="1">MPRSPTHAPRTRIYRPTPRNLARLARLLQAGELVAVPSETVYGLAAHALDASACEKIFAAKARPKTDPLIVHICELAQLTTLAHAGPLAQKLAAAFWPGPLTLVLPKRPAVPAIVTAGRDSVAVRMPQHPLFLALLSACAVPLAAPSANPFGYVSPTRAAHVKAGLGGKIFAILDGGPCAIGLESTILDARNEQQLRILRPGAISAAELSQVAAVRVEDFSQTPNSNEVDESPKIAPGLLSRHYSPRARVVLYEKIPPRLASAAQPDEALLYFQKPPADWPRTDAHRAWLTDNNDQAEAARALFATLRTLDAQGFKTIHAELAPEGPLSTAINDRLRRAAASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQP0</accession>
    <name>A0A139SQP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acnA</name>
        <name evidence="11" type="ORF">AXK12_02580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711097.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02580"/>
    <dbReference type="EnsemblBacteria" id="KXU36919">
        <property type="protein sequence ID" value="KXU36919"/>
        <property type="gene ID" value="AXK12_02580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="9">
        <location>
            <begin position="78"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="10">
        <location>
            <begin position="702"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="906" mass="97534" checksum="0AB559F6F2E42813" modified="2016-05-11" version="1">MTQSQSTLPNPFNTRSTFTDASGAQHSLYSLPALKAAGFAIDRLPVSIRIVLESLLRNCDGKRVSEEAVAELASWAPKATRTAEVPFVVARIVLQDFTGVPLLVDLAAMRAAVHKLGLDPKLIEPLVPVDLVVDHSVQVDFAGSAEALAKNLELEFTRNRERYQFLKWGMQAFDTFKVVPPGIGIVHQVNLEYLAQGILKDTHGTYYPDTLVGTDSHTTMINGLGVVGWGVGGIEAEAGMLGQPVYFLTPDVVGVHLTGALSEGVTATDLALTITELLRAKKVVGKFVEFYGPGARALPLVDRATIANMAPEYGATMGFFPIDEETSLYLRGTGRSEAHVATYEAYYKAQELWGIPEKGQIDYSVDVELDLSTVVPSVAGPKRPQDRIELPALKENFVSAYSRPVAQSGFGKSADSYAQRASVELDNAKAEVGNGSVLIAAITSCTNTSNPSVMLAAGLLAKKAVERGLSVNPAVKSSLAPGSRVVSDYLNKTGLTPYLDQLGFQTVGYGCTTCIGNSGPLHPAIEDAIVGNDFVAASVLSGNRNFEARVHQNIKSNFLMSPPLVVAFALAGRVDIDLSREPLAKDKDGRDVFLKDLWPTLEEVRDQMSAALKPEVFKTLYTDFASQNPKWNEIPSSTGNVYEWDSASTYIQEPPFFTDFSQTPGGITEIKGARAMGIFGDSVTTDHISPAGAIKKTSPAGQFLSEAGVEFADFNSYGSRRGNDRIMTRGTFANVRIKNLMLGGEEGGNTLLQPEGTKLPIYDAAETYKARGVPLIVLAGQEYGTGSSRDWAAKGTRLLGVRAVVAQSFERIHRSNLVGMGVLPLQFKEGTTAQTLGLDGTEVYDVVGLSADVKPQQDLALRITRADGRVEEVPVTCRIDTPIEVDYYEHGGILPYVLRQIIGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQW5</accession>
    <name>A0A139SQW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02590"/>
    <dbReference type="EnsemblBacteria" id="KXU36932">
        <property type="protein sequence ID" value="KXU36932"/>
        <property type="gene ID" value="AXK12_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="59"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="253"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="480" mass="51645" checksum="6D01F269F8E43740" modified="2016-05-11" version="1">MVLFLLGILVGVSVLSLALYRAGKREALLEEEKQQVTQSRELVVDFMHHMVEALGEGLGQEELRQRIVHAAILCSGALSAALFERDRQGQMRGVAVEGLFPPHRPLPPNAIEKLTTRAKFIEGVLRSESFPDDEGIVGAVVQTGRAQLVADAATDPRIIRHQDAALKVRSVIAVPLAFRGELFGVLAVANSADGTAFSQADFTLMQSLAEQAALALHNLRLLNYQIEKQQLDLDLSLASGIQQMLLPSELPQIDGLALDARYTPAQKVGGDLYDVLCLSPERLGVVVADVSGKGIPASLLMATCRTHLRQIAPRHSSPAAALCELNRAIGSNLAGGMYITLLYAVIDLRESTVTLARAGHELPLFLRQNAVSAAPTAEFVGSEGMALGMMPPEVFDAVIADHSEPFRAGETLILYTDGLTEAPNEDGKEFSGARLADVARTLHRRNAHDLADGLLEAVTRFTGGGPQRDDLTLLTIKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQY0</accession>
    <name>A0A139SQY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_02695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711118.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02695"/>
    <dbReference type="EnsemblBacteria" id="KXU36880">
        <property type="protein sequence ID" value="KXU36880"/>
        <property type="gene ID" value="AXK12_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="129"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="257"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="376" mass="41467" checksum="1E25B19DF49FD62F" modified="2016-05-11" version="1">MKFKINRDHFASGLAQVLNVVGSRATMPILNNVLIEADNDRISLTTTNLDLGIRCQIKAEVQESGSVTLPVKRLAGIVRELPSVEVAVAASPNHQVKLVSGGSNFRIMGMAKDEFPPLPEFGEEKTFSLEQSELSAMLKSVAYAQSSDETRYILNGVYFDFSAGKLALVATDGRRLAHIFKDLEVPEASTGAIILPAKTSGELLRLLDKGKKVKVSFDARRAAFQIATDADTKDSGLVDSIYLYSKVVEGSYPNYQQVIPKETHHRIKLERELFLQCVHRAALVCSEKANSIKVKLSPNLLEVTAQSPDFGEAHESMAISYEGPEFQVAFNPQFVMDPLRALTKDEVYLEVKDEISPGVFKTLENFTCVIMPVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR02</accession>
    <name>A0A139SR02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000017">
        <property type="protein sequence ID" value="KXU36978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711086.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02510"/>
    <dbReference type="EnsemblBacteria" id="KXU36978">
        <property type="protein sequence ID" value="KXU36978"/>
        <property type="gene ID" value="AXK12_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="402" mass="44736" checksum="036E5B7D6D860655" modified="2016-05-11" version="1">MSSPQKRIRAPTTEHSTNKSSHKSSPRLLVILRRYLGDIALLGSVFKNLRLHWPEAQIALLSERPYAPVGALHPDLDRVRSFPRKLCEWPDFIRELRRTGFTHVLDFDNSGKTALIARLSAAPVRVTYEREGKPLRQAWAYTATVKISAHDYHRQHITETYLALLSEIGVPIRSREIDLKPSLADQARVQKFARPAAPLSPLIGTGLSHAFGHELGGMEPRVPASQSSLRLLVHPGSRSRFRLWPAERFAAVCDQLQDELDARIFLIAGPGERAIAHAIREAARSHLVLIDEVLSISEFAALCQHFDLMLCHDSGPMHIAAGVGTPVVALYGSQNTRTWAPLGKGHRVLQAALPCSCLADTPTPCVKADSYRNYCVRKLSVEEVYDAVIEAARTEYQSLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR82</accession>
    <name>A0A139SR82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">AXK12_02210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000014">
        <property type="protein sequence ID" value="KXU37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711032.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02210"/>
    <dbReference type="EnsemblBacteria" id="KXU37115">
        <property type="protein sequence ID" value="KXU37115"/>
        <property type="gene ID" value="AXK12_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="340"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="573" mass="63383" checksum="8D7ECDA6B6A35FFD" modified="2016-05-11" version="1">MAKKAQQQSGGAGEAAPKIIFSMLGVSKKIERKEILRDVSLSFFYGAKIGVLGLNGSGKSSLMRILAGRDTEIEGRVHIEPGYTVGFLEQEPQLTGGATVRACVEEGVARLTALAAEYDASWDALAEAADEAAREKIADRQAQLQTELDRLGGWDTAPLVEQAMDALRCPPEEAVVDTLSGGERRRVALARLLLQKPDILLLDEPTNHLDAESVHWLEQHLARYEGTVIAVTHDRYFLDNVAGWILELERGHGIPWRGNYSGWLEQKQRRLAVEQRTEDRRQKAMARELEWIRSSAKARQAKGQARINAYEALLAQDVAEQERHFEILIPPGPRLGNLVVEARGVAKGFGDKLLFSDLDFALPPGGIVGVIGPNGAGKTTLFKLITGLETPDAGSFKVGETVRLAYVEQSRDSLDDAETIWEAISGGQEMIEHGSRRVNSRAYCAQFGFTGADQQKRLGILSGGERNRVLLARVLRSGANLLLLDEPTNDLDVNSIRALEEALANFAGCAVVISHDRWFLDRIATHMIAFEGDSQVRVFNGNYTSYLEDYRRRKGADAEQPHRIKYRRLSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRE6</accession>
    <name>A0A139SRE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711056.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37102">
        <property type="protein sequence ID" value="KXU37102"/>
        <property type="gene ID" value="AXK12_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="116" mass="13460" checksum="17E82C766E5BA9D9" modified="2016-05-11" version="1">MSLNRSEQLVFDYWQESPDERRFWQDKVRASAAEAADDFEAARRLDGELWAYFVERSAVLPRFRESSPNDGIAGGRTSMKNLAELTLRLWTEPRKKPSKAASRDEESQPQGEFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRN0</accession>
    <name>A0A139SRN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711055.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02345"/>
    <dbReference type="EnsemblBacteria" id="KXU37101">
        <property type="protein sequence ID" value="KXU37101"/>
        <property type="gene ID" value="AXK12_02345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="547" mass="61962" checksum="419842A09EE03DA0" modified="2016-05-11" version="1">MMKLAKEGDLGLFTHITTDSLGAPFIGQLNDFPEAERAIVWFGGQIARVVGLMPAANLILILSCIVAAVSFYTAARFWKISRLSAWVFAVVYAFLPHNQRSLDSLGIIFTGLLPLQFYCLWYIATVQKVSWRSFRFRLTLLIGLLSGFLSIYWVFFFVQMYILALVCRLLKRRAGSITALIPVAGTCLVAGLCLGSFVLYRIDYGANPAALVRSYFDIEIYSIKPMELLIPHWGQDMSFFSDFFSRYYEGGRINVGERLWGIYIGLVAIAGLFFLFFKSIYRQIHKRAPSLPFLAACWVIAYSSFGGIHAAFSLIFNFYNIRSTNRYFVAIATLGFLYFVFVINRYMRSWSFGVRLGALLLIALLGLMDQSYQNYLYPRYDITTSVIRERVMADRDLALRLEDRLEPGAMIYILPAQDFPEPLVGRGAWKLGFFIYDPIRPFLHSTKLRYSYGSNKGRAGADWQLDVQELPPREMAATLGSYGFSGILLNRKGYGDLGKQLLTEFAEAGWPMEFEQGVGSEWVFIPLKPSENPILPTLTPYALSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS08</accession>
    <name>A0A139SS08_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710966.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01895"/>
    <dbReference type="EnsemblBacteria" id="KXU37379">
        <property type="protein sequence ID" value="KXU37379"/>
        <property type="gene ID" value="AXK12_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="315" mass="32840" checksum="AF596F1A034245DB" modified="2016-05-11" version="1">MNKILSKFGPFLGLLLVIALFSIPGEVREYFLSVSNFKIILTQTVIVALAALGMTMIIVSGGIDLSAGSVIAFTSVIGALGLKHGWSAWAVVPTVVASGAFLGLLNGSAIAGLRMTPFIITLGMMGIARGAGKWMASNETVNYTNPAINGWMTTADPYDLSMPPGAWVAVALAIATAIFMRRTVFGRQIFAIGSNEATARLCGVNTVVTKALIYTIAGGFFGLAGLMQLARLRQGDPTVAIGVELDIIAAVIIGGASLSGGAGSILGTMIGALIMSVLRNGSQQMGWPTYFQEIMIGVVIIVAVFLDRLRAHKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS12</accession>
    <name>A0A139SS12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710963.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01880"/>
    <dbReference type="EnsemblBacteria" id="KXU37376">
        <property type="protein sequence ID" value="KXU37376"/>
        <property type="gene ID" value="AXK12_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299392" evidence="1">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="35108" checksum="1C47359A35AF3614" modified="2016-05-11" version="1">MKAITRIVALIVLCIAPLAVKAASPESYRIAVVPKGTSHEFWKSVQAGLVKAQREFAEQGVTVDILWKGPIREDDREQQIQVVENFVARRVDALVLAPLDSRALVRPVELAAQAKIPVVLIDSGLDSDIPISSASTDNYNGGVIAARHLAKLLGGKGKVIMLRDVAGSMSTGLRGDGFADTIAKEFPEIVLLSGDQYGGPTRDTAYRMAQNLLNRYGREVDGVFSVNEPTVVGMLLALRDSGLAGGRVQFVGFDAATPLIEALHAGDIQGLVVQDPLKMGYLGVKSAVAVLRGEAVPQVIDTGCTIVTPENINEPQVDALVHPPLSEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS57</accession>
    <name>A0A139SS57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710964.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01885"/>
    <dbReference type="EnsemblBacteria" id="KXU37377">
        <property type="protein sequence ID" value="KXU37377"/>
        <property type="gene ID" value="AXK12_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299439" evidence="1">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="32"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="35514" checksum="5F8745075893C8BC" modified="2016-05-11" version="1">MKKLPLAAATLLALCAMLPITTQAAPERYRIAGVPKGTTDEYWKSANAGMVKAQREFAEQGVTVDIMWKGPIREDDREQQIQVMENFVARRVSAIVLAPLDGTALVPSVELATRAKIPVVLIDSTLDKDVYVSEASTDNYQGGVIAARRLAELLDGKGKVIVVRVVPGSTSVEGRVNGFLDTIKEFPEIEVISSDQYAGPSRDTAYRTAQNLINRYGHQIDGIFTPNNSSTSGTLLALADVGRGGGKVKHVGFDTDKQSVAALRAGDLQGLIVQDPLNMGYVAVKTAIAKLRGEEIPKLIDTGCTLITAENMDDPEINDLLHPPLDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS72</accession>
    <name>A0A139SS72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710994.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02085"/>
    <dbReference type="EnsemblBacteria" id="KXU37408">
        <property type="protein sequence ID" value="KXU37408"/>
        <property type="gene ID" value="AXK12_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="141" mass="15068" checksum="BD48A32555C2991E" modified="2016-05-11" version="1">MVKSTGIYRGGLNCELTHGPSGQVVPTDAPVDNQGRGAAFSPTDLTAASLGACIVTTLAIVARTRLGLDDAMLAGTRWEVTKEMSADAPRRIVRLTTELWLPIPQDHPAARVLEHAARNCPVSNSLHPDIEKPVTIHWGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSB3</accession>
    <name>A0A139SSB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710990.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02055"/>
    <dbReference type="EnsemblBacteria" id="KXU37404">
        <property type="protein sequence ID" value="KXU37404"/>
        <property type="gene ID" value="AXK12_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="246"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1406" mass="156795" checksum="C4AA93BE373F6784" modified="2016-05-11" version="1">MPSRNPDKTHPHAPAFRLDFPPELPISARAEEIVEAIQRHPVLILAGETGSGKTTQLPKLCLAAGRGTLGRIACTQPRRVAALSVSRRVAEELRVPWGREVGCKIRFNDQTSAATLIKFLTDGMLLAEVQGDPFLGEYDTVIIDEAHERSLNIDFLIGHLRNLRARRPELKIILTSATIDTALFSAAFDDAPVISVSGRTYPVEVIYSPLDGLGSDYAEGDENEDRSDLASIQSARAEALHYIDGAVEAVARILAESHSGDILVFMPSERDIRETCDLLGGVQNRHRCELVPLFGRLSASEQQRVFAPSQARKIVVATNIAETSLTLPGIRFVVDTGLARLSRYSPQTRTRRLPIEPISQSSADQRKGRSGRVAEGLCIRLYSEKDFLERPRFTQPEIQRANLADVILRMLASGLGDIESFPFINRPSTQAIRSGYSLLEELGAIELGSARTLTRVGRELARLPVDPTIGRMILQARREKALREVLVIAAALSIQDPRERPLDKQAQADSAHRRFLHPDSDFLTLLNIWDAYHDEFERLSQSRLRKFCREHFLSYPRMREWRDIHSQLCEAIGDGRKGASPLSSAFSGLEVQDAKTTAWGTAPYRAIHRAILAGLLGNIAEWQEKDRVYKAQRDRRLAIFPGSVLFQRDARKAKGQSPDGRPPSARQKKGANPPWMMAGEIVETSRLYARTCARLDPQWAVELGKHLIKLSHSEPFWDEAKGRVMVKQRARLHGLELEVRAVSYGRIDPRSATEIFIREGLVNDTITWPFDFLAHNRAIRDEVESLFTRTRDSRVLNLDEALYRFYAAQLFTDADGGPHYTSSVAELVDLTRERAAAYPDFLKLRVGDLYDPEADEAAAHALSFPEKLPLQNTALPLNYAYRPGQADDGVTLDLSPREVTSLNEASLDWAVPGHLFEKVEFYLRALPKELRRALVPLAETAKSLSAQLASRDRLTGRRETLTAALAAQLNERFGLHLKPEIWTGRALPEHLRVRVRVTDETGRELCASRELAEIRAKLALAQTEATSTASKAASQAWRAARARWEKLDQAEWAFGEAIPSEVKIGEDAGLPLMAYPGLATRVGQVSAEPSPPWATGVSLKLFKTREEALAETRAGVSALLELGLRHDLGWLARDLRDFRKLGPLVSTLAPLAALEEDAAQMLRRWACDSARCPWRDAGVKSGSASELRAGDFSAALAKAKADLRGIVPKLCDLLGEVLALRQELLVHPTPYTGLGEELTRLLPPDFIRCVSWPQLQHFPRYLRARRLRAERWRQNPKKDADRARQLAPYERALHEFESEARDKPAYRELAALGKLRWLVEEFRVSLFAQELGTAEPVSEKKLDAVIFALRSEDSPQRELSSRGPALRSSSLPAPATSVSKQPIAQASAPLKQPLKSLAALEKLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSC1</accession>
    <name>A0A139SSC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">AXK12_02010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711004.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02010"/>
    <dbReference type="EnsemblBacteria" id="KXU37414">
        <property type="protein sequence ID" value="KXU37414"/>
        <property type="gene ID" value="AXK12_02010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="235" mass="26264" checksum="DDB68D2CA13DC593" modified="2016-05-11" version="1">MPDPQAVNSMFARIALRYDLANRLLSGGTDLWWRWRLVRRVRRAAPRDVLDLATGSGDVAFALCRAMPGVEVSGMDFCQPMLDQAEAKKAAAGGNAAYPSLRFLQGDGLNLPLPDACVDAVTISFGLRNMADRHRALCEMRRVLRPGGRLYVLEFSQAWGWFRPLYLFYLRHILPPLAGLVTRDRAAYRYLNETIEEFPDHLALAAEIREAGFADVRATRMTGGIVALHQCTVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSD8</accession>
    <name>A0A139SSD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710948.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01805"/>
    <dbReference type="EnsemblBacteria" id="KXU37434">
        <property type="protein sequence ID" value="KXU37434"/>
        <property type="gene ID" value="AXK12_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="298"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="549" mass="59328" checksum="D8FF84DBF7E42F51" modified="2016-05-11" version="1">MSADEPESVAQLAEQLGIARVDLTELQVSAELIRLIPHELVRRYELLPLRYEDGGQRRLFVATADPLNTDGLDAIAHLLGVEVVPCFVPREELCAATASHYGREIAAAGAFLESASEHASLDVSAAFPEATSENDAEADLDAPIIQLVHRLIMRAVEQRASDIHLEPLARRFRVRYRIDGVLIEAEAPPKRLQAAIISRVKIMAGISIAEKRLPQDGRIQLKLPSARGDSRNSENQSSSAVGGARAAALDLRVSSLPTSHGESIVMRILDGESLRLGLGELGFMADDRAAFERLIAQPDGIVLVTGPTGSGKTTTLYSCLHAINQPDRKIITVEDPVEYQLSGVNQVPVRSELGMSFAAALRAMLRQAPNIVMLGEIRDAETAEIAIHASLTGHMVFSTLHTNDSPGAVTRLIEIGVKPFLVATSLRGVLAQRLVRKLCPDCAQAHTPSAAELSLLGIGEKEARGATFRRAAGCPKCHHTGYRGRTGIFELLLIDEAMQQLVHAGASASKLRAYARQNGMRSLREDGRRKVLAGLTTIEEVLAETLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSF5</accession>
    <name>A0A139SSF5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DctA-YdbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710923.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37516">
        <property type="protein sequence ID" value="KXU37516"/>
        <property type="gene ID" value="AXK12_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021730">
        <property type="entry name" value="DctA-YdbH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11739">
        <property type="entry name" value="DctA-YdbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299362" description="DctA-YdbH domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DctA-YdbH" evidence="2">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="35680" checksum="FFCCA1012A97B81F" modified="2016-05-11" version="1">MNTARLIAWLVLAWVGALAAHTETVLPSVAATFETGTGPSPVNGAARPSGFPALGGEFAGELHFRSGELAVNGPFHVELAVRREADDASESVVAKLSFRAAELPLPELELSDLQIEAEIEWPRNVARLRVAEFNALGGRVALRPFEINLGNAEAISVGVTAELRGLALDQLARFVPEAVREASGRVSGEVRLSWSEAGGLQVGSGALLIEPDAHAQLRLTAMPGFLTQRTTPRFFWLPARLGRVARWLSLENPAYDTLAEIEEGAQPLHVEALHVALYPDGPEGPRSAAVSLLARPLSGAVVKELRFDINVSGPLDQVLRIGASDAIRLNFGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSG7</accession>
    <name>A0A139SSG7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01660"/>
    <dbReference type="EnsemblBacteria" id="KXU37518">
        <property type="protein sequence ID" value="KXU37518"/>
        <property type="gene ID" value="AXK12_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="170" mass="17809" checksum="BBAA9CE1FE20A48C" modified="2016-05-11" version="1">MARHLSRTPDTARALFVAPNANIQGDVVLGEKSSVFYGAVLRGDIAEIRIGEGTNIQDNAIVHLADDLGAYIGNYCTIGHAAIIHACTVGDECLIGMGATVLDGAVVGARSIIGANALVPQGMQIPPGSMVYGSPAKVIRPLREEELSFLKQSAEKYIEVARAHAALCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSN6</accession>
    <name>A0A139SSN6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">AXK12_01640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710919.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01640"/>
    <dbReference type="EnsemblBacteria" id="KXU37512">
        <property type="protein sequence ID" value="KXU37512"/>
        <property type="gene ID" value="AXK12_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="147"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="365"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="497" mass="55643" checksum="D01213564396E3D4" modified="2016-05-11" version="1">MSQVRVRFAPSPTGFFHIGSARTALFNWLYARHTGGRFILRIEDTDKERNSEAFLNVIYESLRWLGLDWDEGPVVGGFGGDRRGSAGGGDYGPYRQSERGAIYAAHVERLREAGRVYEKDGALWFRLLGERYEAYDPHRKKTVEKVRNTPAVIDDAIRGRVERTEDEDFVIVRSDGSPVFHLVNVVDDITMGITHVIRGEDHLSNTSRHVELFKALGAALPTFAHIPLILKQEGPGKMSKRDQGALIEEYQRRGYLPEALVNFIALLGWNPGDDREKMPISEIVRLFDLADVNQSNARFDDRKLAHMNMLYLLELPEEDFVTRARSYFNAQAEAAELSESGKPEDAEASAAAKSRRELARVALAAPEAYFRAVVRLSQPKIKAIEELPIYTRYFFSEAYPIDEKVRAKVLGKGEPRARLAELIAVLPGVDFASDESIEAALKTMAEAQGQGFGAYQSVARLALTGTNAGPSITAIMRLLGRERVAQRLRDFERELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SST1</accession>
    <name>A0A139SST1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite reductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710897.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01525"/>
    <dbReference type="EnsemblBacteria" id="KXU37645">
        <property type="protein sequence ID" value="KXU37645"/>
        <property type="gene ID" value="AXK12_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="155" mass="17026" checksum="CF144A0E0F2F5D34" modified="2016-05-11" version="1">MSSDLTIYFGTVTGNAESLAFRAQERAQAAGISATLVNLAEISPDQLITEGHALFVVSTWGDGEPPMDVETFYYDLEASDLDLSNLSYAIFGLGDRDYPIFNGFARNLDERLASFGAQALYERAEADVFFDDTYAEWEAGIFPLLEERLALLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSZ1</accession>
    <name>A0A139SSZ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710905.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37654">
        <property type="protein sequence ID" value="KXU37654"/>
        <property type="gene ID" value="AXK12_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="67" mass="7511" checksum="96E50BDB2F2D0BCE" modified="2016-05-11" version="1">MFKRLVFEDYAALCTLIAFAVVALVFLGAIWRALRMTRGQSEHMAALPFEPSPHTSPNTALHQAHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST62</accession>
    <name>A0A139ST62_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01420"/>
    <dbReference type="EnsemblBacteria" id="KXU37660">
        <property type="protein sequence ID" value="KXU37660"/>
        <property type="gene ID" value="AXK12_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="4">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="517" mass="54429" checksum="7D8B603682615BFE" modified="2016-05-11" version="1">MTAADAAFYLTADAFFKANQPAALTYDDVSLATLYSEILPREADTATSLSESLRLPIPIISSDMDTVTESRMAIAMALNGGLGLIHYNMPPKEQVKEVARVKRHIHGLIQDPITVAPTDTISDVLAMIEERKFTFSTFPVVTADRQLAGLLSSSVVKDRYRAKTVAEVMTPRAALVTEAEERVAQDPIAAADAFFNAHIGINKMLVVNARDQLRGLVTSSDVEKITSEAKARRKPARDAQFRLVVGAAVSPHRKPDGSLDRDAILEHIGNLAAEGIDAVALSSAHAHTVSLGELVRLVRNAFPELAIIAGNVTSGAGVEFLARAGASSIKIGQGPGSICTTRIVAGVGIPQLTALHLAAQSARKLGVRLIADGGITKSGDIVKALTLADAIILGGLLAGCREAPGEIMEIGGKLYKSYRGMGSLAAMKSGSAARYGHDKADTVRKLTAEGIEALKEVSGSVDDTLATLIGGVQSGMGYLGAATLEQLRARARYVRVSPAGQKEAAPHDVVEVSTRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST93</accession>
    <name>A0A139ST93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdhA</name>
        <name evidence="9" type="ORF">AXK12_01255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01255"/>
    <dbReference type="EnsemblBacteria" id="KXU37818">
        <property type="protein sequence ID" value="KXU37818"/>
        <property type="gene ID" value="AXK12_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="40"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="363" mass="40107" checksum="1C478BE6115FC936" modified="2016-05-11" version="1">MSKKTNATPPPQPPSTGNDFASAAVNQALSHEQRIDLFRTMVRIRRFEERSLRAYQAKKIGGFLHLYIGQEAVAVGCCSLMGKDDHIITAYRDHGHAIAVGMEMNPLMAELYGKATGCSKGKGGSMHYFAPERNYWGGHGIVGGQIPLGTGLAYAIKYKGLHGAAMAFMGDGAVNQGAVHEAYNLAALWQLPILFVIENNGYSMGTSQERSSAGQLAKRAEGYDMAWDACDGHDLYAVRATMDKYLRRARETSAPAIIEIHTYRYRGHSVADPDNTYRTKEEIEAYRQTKDPIQNFQNRLLAEGVLEDALIKEINDAARAEAEASVAFSEASPWPTVEDIQRDVYWEADNPSQRTSTGQLFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA7</accession>
    <name>A0A139STA7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-arginine kinase</fullName>
            <ecNumber evidence="5">2.7.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mcsB</name>
        <name evidence="9" type="ORF">AXK12_01125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the specific phosphorylation of arginine residues in proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43384"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10533"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.14.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.14.1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710821.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01125"/>
    <dbReference type="EnsemblBacteria" id="KXU37795">
        <property type="protein sequence ID" value="KXU37795"/>
        <property type="gene ID" value="AXK12_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00602">
        <property type="entry name" value="Prot_Arg_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RDXXRA motif of the pArg binding pocket involved in allosteric regulation" evidence="5">
        <location>
            <begin position="353"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="390" mass="42467" checksum="F0ACB93A9A00C256" modified="2016-05-11" version="1">MKSTKSNRPSGKSRRVKPLTLETLLDAPSELATDLASSESVVLMTRIRLARNLAATPFPGWAGAEQREDAYETCRAALNAVSPMRRGLSLSVAELGDLEKQILVERHLISRELSDTKASAGVVISADQSLSVMINEEDHLRIQSLRPGFQLAKAWSAINDLDTALEEHLNYAFSQERGYLTACPTNLGTGMRASAMMHLPGLVISGQMEKIVRAVNQLGMVVRGLFGEGSEASGSIFQISNQTTLGESETDILSRLSSVLSTIGGHERNARARLLESDASTLFDKIGRAYGILRNSHLLNSSEAMNLLSLLRLGVDLGNFPATERSRIDRLFMETQPGHLQRARKGELDPQQRDLLRAALLRAEFAKVAAPAFSAPLPSSDQPTPEPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD0</accession>
    <name>A0A139STD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710867.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37839">
        <property type="protein sequence ID" value="KXU37839"/>
        <property type="gene ID" value="AXK12_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="22374" checksum="20A2E9F9402AB953" modified="2016-05-11" version="1">MDWILDHLQLVIAVAAGFAYWLSARQHQKAAGENEAEGQGGQPQAELHDEERAARERAERARQIREEIQRKIAERQGGPVVHPSRRPAAAPRPQPARAPAAQPQRAPARPNVSSSAAARPDLYAALAEQQRRLAAEQRRLAEARLQAEAIRAGAQSAQATSPQRGGAASGSARRGGFIRAQLRDPAGLKYAVVLREVLGPPVGLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STL1</accession>
    <name>A0A139STL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ORF">AXK12_00885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710777.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00885"/>
    <dbReference type="EnsemblBacteria" id="KXU37948">
        <property type="protein sequence ID" value="KXU37948"/>
        <property type="gene ID" value="AXK12_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="333"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="491" mass="53663" checksum="F97C9934B3CFFB4F" modified="2016-05-11" version="1">MANYEAVIGLEVHVQLRTRSKMFTRVPTGYGQPENTLTDPTVLALPGALPVMNRAALDAIIKAGLMLGCEIAPVCKWDRKNYFYPDSPKNYQISQYDQPICLGGAVEIELPGSARNVMGEHKHIPLTRIHLEEDVGKCTHGASDSLVDYNRAGTPLMEIVSEPALHSGEEAYAYLTALRAAMVQGDISECDMEKGQMRCDANISIRPVGSTELGTKVELKNLNSISYVRAGIDHEIKRQIALLESGGVIVQETRDYDGLTGASQSLRTKEMAHDYRYFPDPDLMPVRVDEAWKARLRATCPELPFDRQRRFFADYALPYTLTSVLVWDKPLADYFEEAVKLAGAQRAQPIGNWIVNDLLRELKAGGAGGAGGLSLSEVRVRPEHIAELVELVESGKLLSQAAKEVFAEMFATGESPAVVAEKRGLLAEPADASELEAWCRAAIAENEKAAAEFRAGKESAINGLKGPVMKASRGKANPKEVDATLRRLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STV2</accession>
    <name>A0A139STV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">AXK12_00865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710773.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00865"/>
    <dbReference type="EnsemblBacteria" id="KXU37944">
        <property type="protein sequence ID" value="KXU37944"/>
        <property type="gene ID" value="AXK12_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="113"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU37944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="350" mass="39314" checksum="70A1CFC6E92B69AA" modified="2016-05-11" version="1">MQHTLDAILTSARAEFAADVPLPSRAEFEAAKARYVGPNGQLTAQMKKMGSVPKEERPALGKLINQTKLDVQQLLDAALARIEAGELRASLGPPIDPTLPAPDIGPGSYHPLSAVREELSRILRKVGFTVADGPEVETEYYCFDALNTPADHPARDTQDTFYLPSSVRFANVPKKTEHEHYLLRTHTSSVQIRTMLKGQPPIRIVSPGRVYRRDTTDATHSANFQQLECLYVDKNVTIADLKALLDYLFESLLGKDTKTRFRPHYFSYTEPSFEVDLSARHLPKVNKEWIEIGGCGMVDPAVFADVGYDPEVWSGYAFGMGIERLAMLLYGIDDIRYFYQNDLRFLRQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU04</accession>
    <name>A0A139SU04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_00765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00765"/>
    <dbReference type="EnsemblBacteria" id="KXU38067">
        <property type="protein sequence ID" value="KXU38067"/>
        <property type="gene ID" value="AXK12_00765"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="43"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="213"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="382" mass="42466" checksum="8826F4EE3EC1B0FD" modified="2016-05-11" version="1">MNPFPKPQSTIVEIRDSAADESGPDARATTARQVTGPSLLWEQRWHPLREEWVLYTAHRGGRPWIGDTHKAADERPPSYDPTCALCPGNLRLEGRRNPDYPGVYCFTNDLPCFGGGEPSAGDAFYQTKRATGTAEVVCYSPDHGKTFVDLRDEECAAVVALWADRYRALGARADVDHVLIFENKGALVGTSNPHPHCQIYAGNMIYGHTVREVESSRRYFAQTGGGFIGQEILRRELAGPRVIAQNAHFVACVPWFARYAYEVFILPRRQVASLADLSGEEQAALGLMIREVTTRYDNLWEMPMPYVMAIHQAPTDGGDYAAYPFHLEFHPPLRKPDTLKYLAGPEVGGGSMTNESDPDEKAAELRAVSGTVHYVRARERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU99</accession>
    <name>A0A139SU99_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/glucose cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710749.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00725"/>
    <dbReference type="EnsemblBacteria" id="KXU38062">
        <property type="protein sequence ID" value="KXU38062"/>
        <property type="gene ID" value="AXK12_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="556" mass="60290" checksum="53AB548B215AC288" modified="2016-05-11" version="1">MTSLDWIIIAGYFVLLATIAWRSSRQTSTSADYFLAGRNLPWFVVGCSLLASNVGSEHIVGLAGNGATNGMAMAHFELHAWIMLLLGWVFVPFYYRSKVFTMPEFLERRFDARARWTLSIVSLVAYVFTKVSVTVYAGAVVFMALLPDTFGSPENAFWAGAITTVILTGIYTVVGGLRAVVYTEVAQTGILILGSAMLTFFGLRYIGGWGELQATLGANAEHFALWRPMNDPDFPWLGILLCSPIIGIWYWCTDQYIVQRTLAARSLKEARRGSIFGAFLKVLPVFIFLVPGMIGYALHTKGVLAIPTDADGHLNGDMVFPTMVTTLMPTGLRGMLVAGLLSALMSSLASLFNSCATLFTVDIYNKLRPGRPESEIVRVGRFATGVVVILGIIWIPVMKLISGGGLYQYLQSVQGYLAPPITATFLLGLFFKRINARGALAGLVLGFILGMVKLTLQAMDGGGAFGDSGLLHAIGSYNFLYAGGWLFLISIVIVVGVSLTAPAPSAKQIEGLTYTSLTAAQREENRRSWGAPEVLGSLGVVAMIVGIYLYFSFWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUE3</accession>
    <name>A0A139SUE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38050">
        <property type="protein sequence ID" value="KXU38050"/>
        <property type="gene ID" value="AXK12_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU38050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="148" mass="17203" checksum="C5C7E1F0B8C7666E" modified="2016-05-11" version="1">MLFGSTQNVNFLNKLYLDNLLIRSGGELIVRNWKEGRDFIFVKKTSKNLADALKKMKFDGYDPRRIQLEDYDDEYWEVKGAPEPATYGAGLMLGVLGLVRYRRRQKQRSARLTSERHFSTTRGAAVSDRFHLIWELALSLRDKTNSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF7</accession>
    <name>A0A139SHF7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">AXK12_08095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713247.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08095"/>
    <dbReference type="EnsemblBacteria" id="KXU33989">
        <property type="protein sequence ID" value="KXU33989"/>
        <property type="gene ID" value="AXK12_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="76" mass="8211" checksum="2347C081A89248CE" modified="2016-05-11" version="1">MAKICAITGKRPTKGRIIHRKGIAKKSGGIGTHITAITPRTFRPNLQRIRVKLPNGGTKRMLVSVKALKAGLVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG6</accession>
    <name>A0A139SHG6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_08290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713307.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08290"/>
    <dbReference type="EnsemblBacteria" id="KXU34018">
        <property type="protein sequence ID" value="KXU34018"/>
        <property type="gene ID" value="AXK12_08290"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="250" mass="25875" checksum="FB44B58DBFCB4180" modified="2016-05-11" version="1">MSYTFTNRTAVVTGAGRGIGRAIAELLAKHGVNVICVSKSAASCGATAEAIVAAGGRAKALAVDVADGAAVAAAAESLLAEFPAIDILVNNAGITRDGLLFRMTDEDWESVLATNLTSCFHWCKQLGRPMTRTRWGRIINIASVSGILGNAGQANYSAAKAGMIGFTKTLAREFASRGVTANVVAPGFVKTDMTTDFVNNPEVAEKVLSAVPLKRFGEVADIAHAVAFLASEEASYVTGQVFAVDGGMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI1</accession>
    <name>A0A139SHI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_08230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713290.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08230"/>
    <dbReference type="EnsemblBacteria" id="KXU34009">
        <property type="protein sequence ID" value="KXU34009"/>
        <property type="gene ID" value="AXK12_08230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="25574" checksum="EE7E0AC45DBA72BB" modified="2016-05-11" version="1">MLQIDRLIKRYGGYTAVNGLSINIAPGELFALLGPNGAGKTTTINCLLGFIQPDEGRALIDGLNVSDAPLETKRRLAYIPEQVNLYGHFTGLENLAYFAELSGHRYEEPRLRGFLAEAGLQTEAHARRVSGYSKGMRQKVGIAIALAKEAKVLLLDEPTSGLDPSASHEFSRLLGQLRERGVAILMATHDLFRAKEDATRVGIMRHGSLVRELTAAEISHTDLEKLYLETMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI8</accession>
    <name>A0A139SHI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08390"/>
    <dbReference type="EnsemblBacteria" id="KXU34035">
        <property type="protein sequence ID" value="KXU34035"/>
        <property type="gene ID" value="AXK12_08390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="410" mass="45740" checksum="B8FC57346C7A0BCF" modified="2016-05-11" version="1">MDDALRESPRMLLARLELDVADGALTQARAGLYPTLNGFSRGLLTSDIRRDRPGTVNATKIYYDIGLSQPLFHWGEKRNNARIGAIRASLAERDYEEGYRLLAREIRQGYLRLISLKSQLVGARFGREQAAAALRAAEERVKAGLITGAELFGPRIALERAELSEASAEAAFIAASEQFELLTGAAAPTEVELPEELPEIQAQAEATGLLFAEFLAEPKPSTPTLERLEEETEIARLTYKNQKTRLRPKFNFTLGVSQDEQSYTINSGQRYGVTSRYAGIQVNWAIFDGWANRGAVRSSLARLRSAEARYTQAQSAARQQARAATRALELAQREMQLNDRLLSSSRDYLQIREDDFAAGRISREVLDQAQSGYYSARTSANNARLNYLMAQVELLTKLDRDPLLEHLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHK6</accession>
    <name>A0A139SHK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08170"/>
    <dbReference type="EnsemblBacteria" id="KXU34001">
        <property type="protein sequence ID" value="KXU34001"/>
        <property type="gene ID" value="AXK12_08170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="Extracellular_endonuc_su_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="PTHR13966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease_NS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NUC" evidence="1">
        <location>
            <begin position="73"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="280" mass="31155" checksum="71BBA54A26B4059F" modified="2016-05-11" version="1">MKRLVVNAVQGKKDVTAFEVAWDLWQLYYGKDYVEVDVAERAARKTATTSSDLNYFYGGAPTSASGALRILKNTGYAVGYSDARGNPLWAAYGVSDRPVTEVPPRPEKFVVDRRTVARVTSAAYTGSGYDRGHLAPNYAIALHHGARAQEETFLMSNIIPQRHGLNAGLWKKLEQRIARNYPARFGEVWVLAGPIFGRNPQRLREDVEVPEACYMILVDENAGRLRTLAFIFPQQPLSDDLADYLTTIDEIEARTGLDFFGALPAATQHALESTKASRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHL2</accession>
    <name>A0A139SHL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="11" type="ORF">AXK12_08045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713227.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08045"/>
    <dbReference type="EnsemblBacteria" id="KXU34039">
        <property type="protein sequence ID" value="KXU34039"/>
        <property type="gene ID" value="AXK12_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="851"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="656"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="890" mass="97756" checksum="A9A0CB9E43BDDF6D" modified="2016-05-11" version="1">MSDSKPAAKLTPMMEQYFEVKRGLPDGTLLLFRLGDFFELFYEDAVIASRLLGLTLTKRQDYPMAGLPYHAADSYITKLLAAGRKVALCDQSGPVQPGKLVKRALTRILTPGTTLAASQLDANRNHYLCALSHDKRGLHAAWLDLSTGEFRIASDTQIESLLPVLTALSPAELVLAEGIFSKWEAESQAHHDAGHADLRSLYHFCADHTRSEIPNYHFEPRAGAKTVMDTLGVLNLEGFGISPEHSALGPAGALLYYATETLRARPENLRTLKEYRSSGTLLLDPATLRNLEIFSSSRGTREGSLLDAINRTRSATGARLLERWLSAPTLELHEIHRRQVLVGEFAAQPSRLSALQDSLVQVRDIPRILGRLQNRLRNPRELAGIRDTLAQFPKIRAVLADWNSPSANSSSPEPKRLAAEYADRIAALPDLLALLSRALADELPGDVADGGMIRPGHDAELDRLRSLTTNNKTWLSALETTEQQRTGIKSLKVKFSNNFGYFIEVTKANLHLVPTDYIRRQTTVGGERYVTEKLREKEKEIFTAEERALAREQDLFHALVSSVLAEADALSRTADALAELDVLAGWAALAREWDYTRPTVDDSDQLLIEEGRHPVVEQMLKSPQAAASASASSSAAFVPNDTELCASGAQLALITGPNMAGKSTYIRQVALIALLGHIGCWVPAKSCRIGLIDRIFSRVGASDDLARGNSTFMVEMNETANILNNATRRSLIILDEIGRGTSTYDGLSIAWAVVEHLHSDPQAGPRTLFATHYQELTQLEKHLPRLRNLSVTVKEWNDEIVFVRRVQPGAADRSYGIQVARLAGLPLSVIDRAKEILSRLESDEAVVALPATTSAAAPHPAPSSPEPKLPPKPKKKLTVEPIDDPQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHL7</accession>
    <name>A0A139SHL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_08015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713346.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08015"/>
    <dbReference type="EnsemblBacteria" id="KXU34036">
        <property type="protein sequence ID" value="KXU34036"/>
        <property type="gene ID" value="AXK12_08015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="238" mass="26282" checksum="983B42C3E186F088" modified="2016-05-11" version="1">MPEFALAHWAAPVPLAAINIVQVFLQSDIVGQVITVCLCISSLVTWTVMFGKRSEMKRMGELNAAFEARLRDERSLLDLPESFRQRRVIPYGDLFADAVESYWRADAISRERGDPDPRARIEHAENALQRALSRQTLRYESSMIFLASIVTGAPFLGLLGTVWGVMESFSSVSTQQTASIQALAPGISSALMTTVAGLLVAIPSLFGYNYILAHTKKLITELENFASSLADRIELESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM9</accession>
    <name>A0A139SHM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylase_S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_08200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08200"/>
    <dbReference type="EnsemblBacteria" id="KXU34043">
        <property type="protein sequence ID" value="KXU34043"/>
        <property type="gene ID" value="AXK12_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="327" mass="36785" checksum="83E0B9D08D699881" modified="2016-05-11" version="1">MPHNSQYERYVISPLRFYLRCDLSKADPVFISYFFHSSEGQHKLLANASQTGVPSIARPSSYLKTIELSLPPLKEQRAISHILGTLDDRIANLRQTNATLEAIAQALFKSWFVDFDGVPPEDMQESELGLIPKEWRVGTFGDVAEHPRRGVQPEEIESSTPYIALEHMPRRCIALSDWGMAVGLESNKHEFKRGEILFGKLRPYFHKVGVAPIDGVCSTDIVVITPKSPAWFGFVLAHASSDPFVEYTNAGSTGTKMPRTSWREMSRYAVVLPPESIATAFNEQVQQMVEKIISNIHEVRTLAALRDTLLPKLISGKLRFHGRIHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ6</accession>
    <name>A0A139SHZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713133.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07770"/>
    <dbReference type="EnsemblBacteria" id="KXU34169">
        <property type="protein sequence ID" value="KXU34169"/>
        <property type="gene ID" value="AXK12_07770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="19077" checksum="C0313618C8E1DD27" modified="2016-05-11" version="1">MIFADALHASLSALKALKTIRPQIDDAAALILDTLRHDKKLLICGNGGSAAEASHFATELVGRYQKTRASLPAISLSSDGSLLSCIGNDFGFEQVFARQIAGLARPGDLVVAISSSGNSPNILAALHEAKTLGLSSLALLGRGGGAAAPLATCALTIPSESGAACQEAHLFLIHYFCELIDSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI37</accession>
    <name>A0A139SI37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713179.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07935"/>
    <dbReference type="EnsemblBacteria" id="KXU34193">
        <property type="protein sequence ID" value="KXU34193"/>
        <property type="gene ID" value="AXK12_07935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="25155" checksum="B8DEB570C0689A93" modified="2016-05-11" version="1">MSPTEPTDTAHPKLVTFRKAFFTGLALIAPLVITLWALLKIIALVGGAVRPFLVQFIPGDLPGIPLFWDVLATVIVLLLVALLGYVSRHVFARFLLHTSERLMLVIPGAGTIYNTVKQIVGTFGAQNRNLFSKVVLVQFPKNGSWMLGFVTSKEQAEPQAKTGLNEPWTIFVPTSPNPTTGFLLFLPPEDIVELEMNVADGMKLIISGGSVIPPWAPPTASSDSASRLGSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI57</accession>
    <name>A0A139SI57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_07805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713142.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07805"/>
    <dbReference type="EnsemblBacteria" id="KXU34174">
        <property type="protein sequence ID" value="KXU34174"/>
        <property type="gene ID" value="AXK12_07805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="343"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="483"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="598" mass="65711" checksum="BE1F3DCD7E886F5A" modified="2016-05-11" version="1">MLWTYTPPSAGQVEALTSASGGLSRVLAELLLRHRLADRAAVTQFLHPRLATLADPFVVPQLKRAAERLHRAIERREQVVVLGDYDVDGVSSTTLLVGLLRRFGLAPRFIVPLRAEDGYGLSRSAIDRALEAGRPALFVALDCGTNSHDEIAYLIGLGIDVLIVDHHRSRDDELTAVASPLPQSEGEGGPQCILVNPHIQVDAGELSESYRNFCTVGLVFKLAHGLLKLLRPEGNEIANTIQLREELDLVALGTVADLVPLLGENRILSRHGLKMIEKTARPGLRALMEVAGLPPGQAITPVDISFRLGPRINASGRLADAALSVELLLTSDSRFAETTAQQLDAFNRERQDIERQMTEEAEAMIDAHYADDQGIVLYSDKWHPGVVGIVAGRVTRKYNRPCVVLGNDGELAKGSGRSVTGVNLVDVLADCAEELEGWGGHPMAVGVGLDKQRLASFRQKFAHAVREHAGRDISDAELPIAAWISPEEIGEALMAELDTLHPFGQGNPEPIFGMRGVYLAGAPAVFKDMHFRFQLVDKTWRRLYGVAWKMADRIPPTDAPLDLALKLTWNYFRERKLLQLELVDWRLHENPTRAAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI88</accession>
    <name>A0A139SI88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fosmidomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_07855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713200.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07855"/>
    <dbReference type="EnsemblBacteria" id="KXU34204">
        <property type="protein sequence ID" value="KXU34204"/>
        <property type="gene ID" value="AXK12_07855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="401" mass="41937" checksum="691534E7102BF5C7" modified="2016-05-11" version="1">MPVLSALSVGHLLNDTIQTLPLAMYPVLKDAFALNYTQIGLITFVFQLAGSLLQPVVGAYTDKRPRPYSLAIGMGITLVGLVLLSQAWSYGVIIASVALIGTGSAIFHPEASRVARLASGGRHGFAQSFFQVGGNLGSSFGPLAAMLVVARGQGAVLWFGLVALLGIAVLGWAGNWYAGFLGNKAERQPKRASGGSEPALRPTGARRVKPSASVAKTAWVVGVLLVLIFSKYFYMVSISNYYTFYLIDKLGLSVYGAQLCLFAFLFAVAAGTIIGGLVGDRVGRKQVIWASILGSAPFSLALPQVDTLWAMVALTVVIGVVLASAFSAILVYAQELIPGRVGLVSGLFFGFAFGAGGLGSALLGRLADATSIETVFQICAWLPLIGLLAGLLPKDPGAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB2</accession>
    <name>A0A139SIB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transporter ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_07500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713025.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07500"/>
    <dbReference type="EnsemblBacteria" id="KXU34312">
        <property type="protein sequence ID" value="KXU34312"/>
        <property type="gene ID" value="AXK12_07500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="134" mass="15159" checksum="40D811AA04AC9C16" modified="2016-05-11" version="1">MNSSLYTKRRARPEMNLVPLIDVLVMLVFFAFVTMQFKSATTLNITVPRVQTSGTNQFEGRVEIGIDKEGNISYNGRPTSLEALEGLLQEVKQINRETPILVRADETSHFGAVTQVWDSCRRLGLNKVVMQTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIB4</accession>
    <name>A0A139SIB4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713036.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07530"/>
    <dbReference type="EnsemblBacteria" id="KXU34318">
        <property type="protein sequence ID" value="KXU34318"/>
        <property type="gene ID" value="AXK12_07530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="331" mass="36454" checksum="BE0D12540804DD56" modified="2016-05-11" version="1">MKLIIQIPCFNEAETLAVTLAALPRQVPGFNSVEWLIIDDGSEDNTVQIARENGVDHIVRHTRNHGLARGFMTGLDACLRLGADVIVNTDADNQYNAEDIPALTAPILERRADIVVGARPIKTIAHFSPAKKMLQKFGSWVVRMASKTDIPDAPSGFRAMSRVAAQNLMVFNDYTYTLETIIQAGQKNMAITSVPIRVNGDLRPSRLVKSIPSYIRRSIGTIIRIFIIYRPVRFFGAIGFTVFGAGVLIGLWFLSHYLRGEGGGHIQMLILASVLLVSGFQTFLVALLADLLAANRKLLEEVRFYSKSKIETTEGGSTSAQSKHSKENIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID4</accession>
    <name>A0A139SID4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34338">
        <property type="protein sequence ID" value="KXU34338"/>
        <property type="gene ID" value="AXK12_07640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="190" mass="20833" checksum="A71552AD133DC471" modified="2016-05-11" version="1">MVGRIEGDHYVAPGGLYRVKIPVLLQLGGTISDTGNVVVFRDDYSVHVSIGAFELDATQRWELSTMEREDYLNAFFTTLVMPDFARMFPGSQIEATQFDAGRLGGVVFCVTLLPGGSMFPTPFAEARAALPVAKRGNLIFAQNGVIYVLSTELSERLGKAHKMTAEEENALLASRLDALLATMQFAEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIK2</accession>
    <name>A0A139SIK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_07565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713047.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07565"/>
    <dbReference type="EnsemblBacteria" id="KXU34324">
        <property type="protein sequence ID" value="KXU34324"/>
        <property type="gene ID" value="AXK12_07565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="59"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="384"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="417"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="625" mass="69185" checksum="60F172233CC92090" modified="2016-05-11" version="1">MSTAKTKVAESAQTPPPPAKEALTLNDTDHENEVQFKPLEWGLIRRLFGYAKPVKGKVAWLVALTLTRSVQLPMITWAVSLIISGPIAGHDTQMLLWALLGYLVLALSTDGIFHFRMRFALEVGESVVSGLRTEIFEKVQRQPMGFFHRVKLGRVLGRVTSDVESLRVGIQDVLFVTITQGGQLIVAAIIMAFCDFVLFLVVVGMAPILWGVNRHFRMRLSSESRAASESFSRVTATLAESVNGIRVTQGFVRQETNAGLFRNLLNTHSRFNLALARTSAILIPMLELNSQFFIAILLMVGGWRTFHDLMTIADLIQFFFLANLFFSPLATLGAQYNNALVAMAGAERVFWLIDHKPDWEDAPDAQPLPDPRGQGAAITRGARVEFRNVTFGYDPQKPVLHDINFTAEPGQTIGLVGHTGSGKSSIIGLVAKFYLPTAGEVFVDAHEVRTITSHSLHQQMGIVQQQNFLFTGTVLENIRMSRPEASDDEVREAARRLDCLDIFEALPDGLLTEVGERGSGLSVGQRQLICFTRALLADPRIVILDEATSSIDAMTEARLQTALVELLRGRTSFIVAHRLSTIRHADQVLVLDQGRIVERGRHEELVALGGRYNELYSQFVQTAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIK4</accession>
    <name>A0A139SIK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07445"/>
    <dbReference type="EnsemblBacteria" id="KXU34351">
        <property type="protein sequence ID" value="KXU34351"/>
        <property type="gene ID" value="AXK12_07445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="PTHR35339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="42991" checksum="903259CE26EE2464" modified="2016-05-11" version="1">MRAEWCEWARRLAAPIFDALDKRELKLRMPVESTATHSRAPVAHLEALGRLLGGLAPWLELGPDDSPEGQLRGQMAEAARRAIDAATDPESPDVMNFSQYEQPLVDAAFLAQATFRAPTELWEKLEPRVRANLVARLKETRRVPFPETGNWQLFAAFVELALARGGEQRDDSRFLPALENFKTWYLGDGAYGDGPEHRWDYYNSFVIHPMLLGILDEAAQESDAHRQFQKEALVAARRYAVVQERMVAPDGSFPVIGRSIVYRCGALQALADIALRRELPDSIPPAAARTALTRAIRRTLGAPGTFDEQGWLQLGLAGHQRSLAEFYICTGSLYLCSVALLPLGLPAKDAFWSDPHAPTTWERIWGGEDAPADGALYGIPPRLPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM2</accession>
    <name>A0A139SIM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712909.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00470"/>
    <dbReference type="EnsemblBacteria" id="KXU34422">
        <property type="protein sequence ID" value="KXU34422"/>
        <property type="gene ID" value="AXK12_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299249" evidence="1">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="31854" checksum="3E6B0B33D3CBB408" modified="2016-05-11" version="1">MIRCTASLLFFSGLSLQLLDAHPAGAQTSESASEPVALHDGESLHYRIAWGIFPGAGEIKISAEKLPAQSPIDADSESAPVLRITTSTHTSGTLKKLFRFRAESLADFDLHTGLLQRSEERSKSKRKQTGQQLHFDYAARCADYRNEVQPEKSKTLVLPPGQPMDLITSLMQTRAWELVPGQSRDALVIFDDDFYELTIHATGYETLTTPLGKFRTLVLEPRMERTEPKGMFKRGSTVKVWISQDAQRLPVRFQVEFKFGSGIATLIAYRPPNARVGHSEPARPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP0</accession>
    <name>A0A139SIP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_00435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00435"/>
    <dbReference type="EnsemblBacteria" id="KXU34442">
        <property type="protein sequence ID" value="KXU34442"/>
        <property type="gene ID" value="AXK12_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="27920" checksum="BF671B6BC3ABD411" modified="2016-05-11" version="1">MSVTLQIWRQAAADKPGHFVEYKATNCNPNMSFLEMLDVVNDDLEKRGEDPIAFAHDCREGICGTCSLVIDGKPHGPHEGIASCQTYMRSFEDGAVITVEPYRAKPFPVIKDLITDRSAFDKIQQAGGFISIRTGAAQDANALPIPKQDADLAMDAAACIGCGACVAACKNAAAMLFVSAKVSQFALLPQGQPERDTRVLNMVAKMDELGFGNCTNQYECSAACPKLISHDFIGRMNRDYIAATFRAACKDKPAASTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIT2</accession>
    <name>A0A139SIT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AXK12_00595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712959.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00595"/>
    <dbReference type="EnsemblBacteria" id="KXU34446">
        <property type="protein sequence ID" value="KXU34446"/>
        <property type="gene ID" value="AXK12_00595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="400" mass="44008" checksum="FDD14BEB3CE72653" modified="2016-05-11" version="1">MAEHEQFMRRAVELARSVWGTTHPNPMVGAVIVESSATDSEAPGTILAEGATSPDGGPHAERVALNAWREDEPHYGATPHTTLYVTMEPCSTEGRTGACTDAIIASGIRRVVVGTLDPNPAHAGRGIDILREAGIEVMTGILEAECRGLNIIFNHWITTHTPLFAAKTATTLDGRIACRTGDSRWITGEVARADVMRWRRLFPAIAVGAGTVMQDNPRLTSRIEGEEEWCPIRFVFDGLLSTASRLSTRGLPALYTDEFKHRTIVVTTPHGGLGYVRQLRERGVQVWVLPSPTQRVGWAEFRQKCAGEQIFGVYIEGGAQILSQLLREAQIDYLFSYQAPMLFGDDRAKPMMRGLRTERLGQAVRLAEPLHTILGDDVLTRGRVVYPNDLSLDETVFSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIV8</accession>
    <name>A0A139SIV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_00395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00395"/>
    <dbReference type="EnsemblBacteria" id="KXU34410">
        <property type="protein sequence ID" value="KXU34410"/>
        <property type="gene ID" value="AXK12_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299285" evidence="3">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="29191" checksum="D0F91524FFA1DD68" modified="2016-05-11" version="1">MAAFRSGVFPFLMSSPEKSAAAAVAPTAPASENAPASPSFEEKLNGFWAKNRKLVFLLCAVVVVVIVAREVSVLSAAQSRERLAQSYATAAATPEGLRQFAQDNAGLQLGGVAWLQVADAAYEADKFSDAASAYEQSLKGLARGSTLANRAALGLAVSQLKGGSEAQGKAALAALADSPSVSVAVRAEAAYHLALSAHVAGEQEAFAQRATQLAQIDPASLWNQRLLSLQVTRSMSGASAGATSASPSVSILPAALLRPAAQSEAGESAPAEEPSEPVIKFNLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIW4</accession>
    <name>A0A139SIW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712935.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00550"/>
    <dbReference type="EnsemblBacteria" id="KXU34434">
        <property type="protein sequence ID" value="KXU34434"/>
        <property type="gene ID" value="AXK12_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="34816" checksum="8B7CC5AEADB488C1" modified="2016-05-11" version="1">MSTVTTRNRTLAMGEDEATNGARAMVNAPFGRALARIAKENPAIVGLTADLGKYTDIHPFRDACPERFFNIGMAEQNMIAVAAGLARTGKTVFATTYGVFASRRAYEFAAIACAHSNLNVKIIAGLPGLTTGYGGTHQAIEDVALMRMIPNMVVIDPCDAVEIESAVEAIAAHQGSVYMRLLRGQVPRVLPENYTFEIGKARPLREGTQIGIISTGLMTERALDAAAALEARGISVGVLHVPTLKPFDGVAVARFAAGVEYLVTAENHVVQGGLATLVAEALFDAGQVKPLTRIGLPDQFIECGSVQTLQAQYGISLDAMIDTIGALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIY6</accession>
    <name>A0A139SIY6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712946.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00600"/>
    <dbReference type="EnsemblBacteria" id="KXU34440">
        <property type="protein sequence ID" value="KXU34440"/>
        <property type="gene ID" value="AXK12_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="221" mass="23225" checksum="EE87E2BCB42DDB08" modified="2016-05-11" version="1">MKLFLATGNAHKVRELGELIAELDLTQQPGLRPRDCAEIRRALTLESAASLGGMPPVAEDTGTFVGNARKKAHALAALLPTDEPDVWALADDSGLCVDALGGAPGVESAYYAGPQADSAANLAKLVAEMRDVPPGQRGAHYVCVLVLCAADGREQVFRGECHGSLALSPRGQGGFGYDPLFIPHGFDKTFGELPASVKHTHSHRRQPVAAAIHALATRACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIY8</accession>
    <name>A0A139SIY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34535">
        <property type="protein sequence ID" value="KXU34535"/>
        <property type="gene ID" value="AXK12_07220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="96"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="399" mass="42638" checksum="3AC46D7E0C7086E1" modified="2016-05-11" version="1">MVAPFFYHFYAQELTFGLRGTPPLSLSLMFKRSAFFLLGALVLIGGIVFVKVAQVRAMMAQDWSQPPVSIVSAIANEEAWEQSFQAVGTLTAVQGIIVETELDGKVVEIAFESGAEVSAGDLLLRQDTTSEEAQLADAQASAALARINYERASELRQQGANSQSEFDTARAALSSAEAQVATIKATIEKKTLRAPFSGRLGIREVNFGQFLRGGQPVVPLFSFDPIYVDFSLPQQHLTAIQVGQVVKITVDAFDGESFEGRLTAVNPQVDTVTRNVQLQATLANPDGRLRPGMFAKAQVLSAEVQHYVTLPATAISFSPYGDAVFIVEARDDGVEGLRVRQQFVKIGPRRGSQVAILSGVESGSQVAVGGLTKLQNGAAVAINNAVVPSSDPAPVLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJN5</accession>
    <name>A0A139SJN5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712750.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34769">
        <property type="protein sequence ID" value="KXU34769"/>
        <property type="gene ID" value="AXK12_07005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="95" mass="10876" checksum="E91F362D5D255274" modified="2016-05-11" version="1">MIIGDRSTLQVIDWQDGHDHLLVRKDSVHLEDALKKIKFMGYDHNKLQKGDYDSNFWEITPFPEPATYGSLFMAGTVSLSLLRRRQKARLGSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ8</accession>
    <name>A0A139SJQ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712744.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06990"/>
    <dbReference type="EnsemblBacteria" id="KXU34766">
        <property type="protein sequence ID" value="KXU34766"/>
        <property type="gene ID" value="AXK12_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="328" mass="36548" checksum="447F7446C890DE3C" modified="2016-05-11" version="1">MTELLIIKPSSLGDIVHALQVATSLKAQREDLRISWIARDIFAPLVQACAAVDRVYLFERKGGLRGFSRLMREVRQVRFDYVFDMQGLLRTGLMTARSLAQRKVGRWDSREFSSVFYHEEVTLPPAGTESHAIDILLQFASVLGAKPELTGDLVFRDSEKLHPGFPSTAAEFSHGQRLQAPVLMFPDSRRAEKKWDGFLALTQHLLFNDRQRRVIWAGDKYIPDREGLPSDRFLNLTGNTSLVSLPTLIRGSDWVVSNDSGPMHLSAALGVKTLGIFGPTDPARYGPYPLTRPTNVVVRAPALSMISAKEVYARMCAAESQLGGRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ0</accession>
    <name>A0A139SJZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the porin LamB (TC 1.B.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06455"/>
    <dbReference type="EnsemblBacteria" id="KXU34875">
        <property type="protein sequence ID" value="KXU34875"/>
        <property type="gene ID" value="AXK12_06455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034219">
        <property type="term" value="P:carbohydrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003192">
        <property type="entry name" value="Porin_LamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036998">
        <property type="entry name" value="Porin_LamB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02264">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299272" evidence="5">
        <location>
            <begin position="29"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="463" mass="51507" checksum="58C65E88932B1032" modified="2016-05-11" version="1">MMPTIINNIKLLPLAALSLIGVNSPIHAATQSIYDEIPPSENPYLDSISAEGEPASAKSKSEAEDWNSEFKIYFRAGMVDGMEQNREFKLPGAASKYRLGNEFDQYGEFLFRQDLARLGDGSIVSLEAGGEIKYPYGVHHFGDKEGDPRLTQSNLIWRNIPWLRGGALTAGRTLYVKNENVHIYDFDYQDLSGLGVGIQDVPLGPVKATWTLTRQDDLDQEDYVTRNNLLFEGLQITPGGFIDVGFTHIAKNKELPGTNSGWSASLQHRQLFSDQEENIFAVQYGEGPGTNLGFTGNLALDRTNTSWRLIDTYEWQNERFGGQVLGLWERDHFSSGLGQDVLSVGARTTYSITDFFKLALEVGHDRIKPDGSDALDMTKLTFAPILSPSGSGFWKRPEIRLFYTFGLWSSAAQEAADRLHPGSALSNTGAFGSALHGNNFGIQVEYWNDNYTPVKDTIKYMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK44</accession>
    <name>A0A139SK44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712583.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06595"/>
    <dbReference type="EnsemblBacteria" id="KXU34896">
        <property type="protein sequence ID" value="KXU34896"/>
        <property type="gene ID" value="AXK12_06595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="127" mass="14067" checksum="393A933697E0955D" modified="2016-05-11" version="1">MPATLLLVEDNEMNRDMLSRRLATRGYQVLLAEDGQQGIDQTLSGKPDLILMDMSLPVLDGWEATKRLKADEATRHIPVIALTAHAMRGDREQALAAGCDDYETKPIDLPKLLEKIEALIAKNQSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKG0</accession>
    <name>A0A139SKG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_00135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00135"/>
    <dbReference type="EnsemblBacteria" id="KXU35016">
        <property type="protein sequence ID" value="KXU35016"/>
        <property type="gene ID" value="AXK12_00135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="350"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="459" mass="49617" checksum="5DB3992982E3DA70" modified="2016-05-11" version="1">MKALWSPTGRIALERDFWIAVMKAQRELGLAIPAAAIADYERVKSQIDLDSIDARERLTLHDVKARIEEFSGLAGREFIHLGLTSRDLTENVEQLQVLRALRLVQFKAAAALSRLAAQAATHRDQLLTGRTHNVPAQPTTLGKRFAMFGEELLSAFTRLGELLGRYPVRGLKGAVGTQLDQLTLFGGDFKKTQKLEQRILKHLGFKAALSAVGQVYPRSLDFEVVTALHQIAAAAASFATTLRLMAGQGLLSEGFQKGQVGSSAMPHKMNARNCERICGFTTILSGYVTMCAGLAGHQWNEGDVSCSVVRRVALPDAFYAIDGLLETWLNVLGQMTVFPAAIAAENARQLPFLATTTILMEAVKAGAGRETAHEAIKEHALAAARALREGDTASAPDLVERLAGDARLGLSETALRKILAEAHRFVGAAPAQVDHFVATSRALAKAHKGAARYAPMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKG9</accession>
    <name>A0A139SKG9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712416.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00350"/>
    <dbReference type="EnsemblBacteria" id="KXU35051">
        <property type="protein sequence ID" value="KXU35051"/>
        <property type="gene ID" value="AXK12_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="358" mass="38404" checksum="0AF6A93CE6A6B26D" modified="2016-05-11" version="1">MSTASYTVPPFLRDLLAARSPSGYETEAQAVYDAYVQPAADAYAKDALGNRLATLNANGDPILMLAGHLDELGLIITYINDKGFLYFDTIGGHDRSVISGRRVRIQTAQGIITGVTGKRAIHLMDEADRKKVPERHELWIDIGVASKAEALDRVQIGDVATYDHDLELINGTIATARAFDNKVGAYAVGETLIRLAADKSTPLAAKVVSVGTVQEEVGVRGATTASYAVAPHIAVAIDVGHATDHPDCDNRKFGEFKLGGGPILCRGSNINPKVFAKLLAAAQAEKIPYQIEADPRPTGTDARAVQIARGGVATGLVSIPLRYMHTPSEVVDLNDVEHTVRLLVAFARSLEKADYAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKH2</accession>
    <name>A0A139SKH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">AXK12_00260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712388.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00260"/>
    <dbReference type="EnsemblBacteria" id="KXU35036">
        <property type="protein sequence ID" value="KXU35036"/>
        <property type="gene ID" value="AXK12_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="214" mass="23027" checksum="65BE8912798F83F9" modified="2016-05-11" version="1">MTPSFEHLLKTLKQLPGLGHRSAERIALHLLVEKQERLPRLVAALDEAARSVRRCTRCGNLAEAELCPICADPTRDHGLVCVVEQVPDLVAIERSGAYRGTYHVLHGKLSPIQGIGPEDLHLSPLLARLAAGEIRELVLALSGDVEAEATCHYLTAQVTEVTRSTTAHVPEAATSRPSSVTVTRIGFGLPSGGGVLYADSVTLKSALEARRDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKI2</accession>
    <name>A0A139SKI2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712375.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00225"/>
    <dbReference type="EnsemblBacteria" id="KXU35030">
        <property type="protein sequence ID" value="KXU35030"/>
        <property type="gene ID" value="AXK12_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027149348" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="277" mass="29181" checksum="0C197172487CC1ED" modified="2016-05-11" version="1">MKNPLRLLSFLAAGFALTAIAPALQAQKLVIKGSDTLGAKLVPTIAEDYRALNPGRSFEIAAEGSSTGIAALISGTADIGMSSRRARPAELSNGAAKGVTLRPLIVCYDGIAIIVNAANPITTLTKRQVEQVFTGDLRSWDDLGSGAASGPISIYTRNTASGTYADFKALAMNKRDYAPSSQKLAGNEQIVAEVAANPNGIGYVGLAYINAPGVKVVAIEGDLPSKESVLANRYPYARPNFFYTNGEPQGEAARFIDYVLSEAGQQVVERVGFVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKJ0</accession>
    <name>A0A139SKJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">AXK12_00125</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712344.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00125"/>
    <dbReference type="EnsemblBacteria" id="KXU35014">
        <property type="protein sequence ID" value="KXU35014"/>
        <property type="gene ID" value="AXK12_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KXU35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="274" mass="30670" checksum="1A1A9B9CC2FB781A" modified="2016-05-11" version="1">MPELPEVETTRRGIAPFMSGHVLRQLIVHESRMRWPIAADLPGRVSGQVLRRCDRRGKYLLLHFDHGCLLVHLGMSGSLRRVSLSEPRRKHDHVEWCFDESRFLLHDPRRFGALLWHDAQQGPVETHPLLAHLGVEPLGEAFTASHLQRGIRGKQQAIKLALLGGQIVVGVGNIYACESLFRAGIHPLTPAGRLSTRRVERLHAAIQAVLENALDSGGSTLRDYVNASGQPGAYFDAHAKVYDRAGQPCHTCQTPIRRIVQAQRATYYCPKCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKL9</accession>
    <name>A0A139SKL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">AXK12_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712422.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00210"/>
    <dbReference type="EnsemblBacteria" id="KXU35054">
        <property type="protein sequence ID" value="KXU35054"/>
        <property type="gene ID" value="AXK12_00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="276" mass="30519" checksum="0FF7CEFD4EDA93D7" modified="2016-05-11" version="1">MTTGTSATRAALPLADKLKPKRVTPTAIEVDQLDFAYGAKQALFDVNLELPARRVTAFIGPSGCGKTTLLRCFNRMNDLVPEARLTRGAIRIHSADIHAPEVDPTLLRKRVGMVFQKSNPFPKSIYDNVAYGLRIQRGRRSRVQLDEAVERALRAAALWDEVRDRLHDSGLALSGGQQQRLCIARALAVEPDILLMDEPCAALDPIATAKIEELIAELKRRYTIVIVTHSMQQAARCSDKTCFFYMGRLVESGDTQQVFSKPANPQTAAYISGHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKV0</accession>
    <name>A0A139SKV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712134.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05675"/>
    <dbReference type="EnsemblBacteria" id="KXU35193">
        <property type="protein sequence ID" value="KXU35193"/>
        <property type="gene ID" value="AXK12_05675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="15231" checksum="A17C0B1DF591B290" modified="2016-05-11" version="1">MSNRLDERLVFEADCAPRRVMELFTVKWVSMVLHALDRWPGGRCRTGQLQRALPGISKKMLVQTLRDMEMRGLLARHVYTVVPPKVEYELTTLGKTFAGAVEMLYRWGQEHAAALDELEANGTVSTGARGKIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY6</accession>
    <name>A0A139SKY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05685"/>
    <dbReference type="EnsemblBacteria" id="KXU35195">
        <property type="protein sequence ID" value="KXU35195"/>
        <property type="gene ID" value="AXK12_05685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299343" evidence="1">
        <location>
            <begin position="39"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="659" mass="71002" checksum="B06EB1CC1AA830F4" modified="2016-05-11" version="1">MFRKTPTAKPVTDRAKLAAPAAFAALALALTAVPRSYAQNDAAALDLPDLIINSSRVANPEPTGTFAMPVSALRYEPLVDVQGRNLAESQADIIVRGGVFENTGFRIGAATLIDPQTGHYTAELPIAPQMLGLPSVRTGAANALGSTNVGVGTIDYRWRALSPNQSNGSISLGAGEDSLLRGEVYQSGAIELGGLKGRIGTLLGIGASLGGDIDYARSSSDGPITYGDHDFERVAGRAQLRTANTQTDLFVAYQAKFFGWPNLYTPFGVAESDNLQTKLAMLNHRRARNGGGHFEVSAYTRRNKDDYEYDRLIPGLFNPYLHTSRMRGFAIDGREVLGDGPAAGASAWGGEWSLRYRAEWLSDSLQSTSLNQGHYNDRDTYKLTLGATREWAAASGGEWLATLGGTWDDSNRDSGTASPVVELAHNFAAGSLWRSVALGYSEATQLPTYTSLNASPSGGLFRGNPDLGRSTSRNLELSASAAALAGWQASIAVFHRWDDSLVDWTFNTASPAARTANAVDIRTLGGELILRGEWGSGSLTLGYTALTKEADYRSAAVDASFYALNYARQRLTAAFVWQFAEGWELRMDNDARIQAKNTLRTRGGRHALRSALGLVWKPAGLRGVELALQADNLWDSEYQEVPAVPAAPRQLSFTLRHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY9</accession>
    <name>A0A139SKY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5069 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712225.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35231">
        <property type="protein sequence ID" value="KXU35231"/>
        <property type="gene ID" value="AXK12_05895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031849">
        <property type="entry name" value="DUF5069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16798">
        <property type="entry name" value="DUF5069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5069" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="153" mass="16875" checksum="E36B6D14975A2C95" modified="2016-05-11" version="1">MASQPIPGSTGVILRELPSAYIPHAATGLLHLPRFIAKASYVKTHGALPPSYAKNYKRGMDGFLCLHLGIEPDAVERAVHESASDAEIDARLREIFPTELRVAEWNRFYVQRGLSGPGRDFLKEALTNMGCADRLSDILTVADLIEFDEGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL01</accession>
    <name>A0A139SL01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712228.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35232">
        <property type="protein sequence ID" value="KXU35232"/>
        <property type="gene ID" value="AXK12_05900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="89" mass="9019" checksum="F361C7D4BE3C7305" modified="2016-05-11" version="1">MAKKAAPKKATPAKPAATKKLTAKKAPVAKKAVAKKTVAKKPVTKKAPAVKKPAPKKAPAKKAPAAKKPTAAKTKAAPAAKKAPAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL26</accession>
    <name>A0A139SL26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712148.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05710"/>
    <dbReference type="EnsemblBacteria" id="KXU35200">
        <property type="protein sequence ID" value="KXU35200"/>
        <property type="gene ID" value="AXK12_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299294" evidence="5">
        <location>
            <begin position="24"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="192"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="622" mass="68089" checksum="0CA572473C848286" modified="2016-05-11" version="1">MTKQLWLPKLAASLLAFAPLSYAQTQKAPSEEPQPTQLSPYVTVATRAPHSQRTLATVVDVITPEEAQRRQLTTFGDVIGQVVGSPTVATGGIGGVNSVFLRGANSNQTLFLVDGIRMNDPNTDYNAFLGGAAIGGGDTIEIARGPQSTLYGADAIGGVISLRAERGTAAQSVSRAGLEAGTFKSVGGYFHSQGESAGVGYNFSVRGTHTDNERENNDFNSVNLSGRVDIDVDPSITVGATVRWFNGDFESPGDRFAPTLDEENNEQNFLGTLFSEFRSSERFTSRVTLGGQSRRFVAEQAGATTNVTKSRRLVLDWQNIYLACCDTLKITAGVTGENLHVKNSGFGNINKHQDLLAFYINQEFHPVENFYLTGGLRHDDYDTFGEKTTGRVSSAVLFAQKTIKLRASYGSGFRAPSFLDLYGVGFGYQGNPNLKPESSRGWDAGVDYYLPSDRGVIGVTWFENRITDLIAFDFSGSFGTTYNIERARTRGVEVKGDVMLAERTRGQLGYTYLDAQNRSQEARLLRRPRHAVTADLGQDFGNGLNVGVGVRWIVDRQDIDGQTFAPFNAEDFTTLRVYVSYAVTEQLTLRLRVENALDERYEEVHGYPSLGTGTFFGADWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL92</accession>
    <name>A0A139SL92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Preprotein translocase subunit SecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712083.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05515"/>
    <dbReference type="EnsemblBacteria" id="KXU35307">
        <property type="protein sequence ID" value="KXU35307"/>
        <property type="gene ID" value="AXK12_05515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="66" mass="7631" checksum="9F1457B4BA03514F" modified="2016-05-11" version="1">MKFFSRTRLFFSELVGELQKASWPTKTELRDYTVVVIIASVLLGLFTSISDFSLYQFVDLFTKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF7</accession>
    <name>A0A139SLF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711980.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35386">
        <property type="protein sequence ID" value="KXU35386"/>
        <property type="gene ID" value="AXK12_05290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="355" mass="39806" checksum="61A607A73E9B0969" modified="2016-05-11" version="1">MNLDFWRGKRVFLTGHTGFKGSWLSLWLQSLSAELTGFSLPPPFTPSLFEQARVADGMRSIIGDIRDPLALREALASSRAEVVIHMAAQPLVRESYKNPSETYSTNVMGVVNLFEAVRASKGIRTVLNITTDKCYENREWAWGYRENEAMGGYDPYSSSKGCAELVTAAYRASFFNPSNYAEHGVAVATARAGNVIGGGDWAMDRLVPDIIKSFSLGEPVLIRSPYSIRPWQHVLEPLRGYLLLSEKLYTDGPKYSEAWNFGPNDADAKPVSWIVTHLVDLWGEGGTWTIDNGPHAHEAHFLKLDISKARSYLSWEPKLSLAQALDYIVEWNKEFEKGGCACDLTLRQIQRYMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM63</accession>
    <name>A0A139SM63_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">AXK12_05055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711905.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05055"/>
    <dbReference type="EnsemblBacteria" id="KXU35625">
        <property type="protein sequence ID" value="KXU35625"/>
        <property type="gene ID" value="AXK12_05055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="293" mass="31023" checksum="39D16549374242DB" modified="2016-05-11" version="1">MNVAEITAKAKVLLEALPYIQDFRGCTFVVKYGGSFMDDPDPAVRRSVAYDIAFLAAVGINVVVVHGGGKAITQAMADSGLETQFINGLRVTTEAAVGVVKHTLDKVVNKGVCEAIVAAGGRPTGFPGDTVLVCQKLSRDDEGQPIDLGFVGEVTEVKAKLIKKAIAEGFIPVISPVALGHDGKPYNVNADLVAARVASVLRARRLVFMSDVPGLLSNPSDPETLISTLKVSQVDKLKKRGVIGKGMLPKVGSAVRALHEGVRRVHFVDGRLPHSILLEIFTDKGIGTEISHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM96</accession>
    <name>A0A139SM96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711861.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04965"/>
    <dbReference type="EnsemblBacteria" id="KXU35604">
        <property type="protein sequence ID" value="KXU35604"/>
        <property type="gene ID" value="AXK12_04965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="147"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="764" mass="85115" checksum="9485F5860A28812D" modified="2016-05-11" version="1">MTYSEELSPQRPLPLVPYPVKVERGTGHFTLTSQSLVIAGHPAETKAAARFIARLKESSGLTLEYREASAAPDPERGTIRFELETPPKLRPEAYTLHITPGHIRILATDEAGLFYAHTTLWQLLGAATEPGLPATLPELLIEDHPRFAWRGFMLDSSRHLQPIAQIKQLIDQAALHKLNTLHWHLTDDQGWRLEIKQYPKLTEVGAWRIPAGKAGRGPDGQPLRYGGFYTQGEVREIVAYAAEQHVTIVPEIEVPGHARAAIAAYPEFGSTGEETTVAPEWGIHPFLFNVDDATFIFLENVLREVIALFPSSYIHIGGDEAIKHHWKRSPSAQAKIRELGLADENALQSWFIRRIAQFLTANNRKLIGWDEILEGGPLPEGANVMVWHTIENAAIAARAGHDVVMCPTNYAYLNRVQSLAHDEPPGHDRMIPLRKLYEFEPVPADLDEKTARHVIGYQANLWTEYVRTAEQVEHMLYPRLCAAAENAWSPASQRDWQRFLPRIAVHLRRIIRAGLRPADSAFSVQIEALPAADATGAVIYTPTQFQLSNQADFGELRYTLDGSEPRSDSALYAGPVQLPELPVTLTASAFFDGQALAKSRCAIIDADSLRTRNAEQLVPDLETCALRLEDDEPLEGERLALPVITQDPIWVWKDAVLDGIRSLEVSVVDLPYNFAFANESVGIPPDAPKEPVYLQLYLDHFEGEPIAQTLVDPHHATAIQTLKLTLPEGNGGPPRDLLFKFTGSEFTATARETLWAIYRVRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMF0</accession>
    <name>A0A139SMF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711793.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35689">
        <property type="protein sequence ID" value="KXU35689"/>
        <property type="gene ID" value="AXK12_04805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299324" evidence="2">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="297" mass="33143" checksum="01CAB473618C52A6" modified="2016-05-11" version="1">MLTRRYAPTPALLLLCVFGFSLSATLPLRAANELETDPWQDALNVDYTTASRKLEKLHKEDPSDTRVAIAHAAALLARDPVTQKNILKARDLLLSLVADLPTSETRYRPLALYLLGRIDQDHIAPERLDSAREFYEQLRREYPGHELADQGTVQLALLLAMQAPDTPLEDAAAKVETFLPSVTADHAKRELHSIAGNLHWYVHQDAQTALPHLIAGRELGYEAFYRNSDVDIMIAGLAREIGLSELAAKHYRRFAAAVPRDTRAYTALRLASELEEQASQRKANASSRNETDTRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMH0</accession>
    <name>A0A139SMH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">AXK12_04855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711842.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04855"/>
    <dbReference type="EnsemblBacteria" id="KXU35660">
        <property type="protein sequence ID" value="KXU35660"/>
        <property type="gene ID" value="AXK12_04855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="338" mass="36040" checksum="A480D41BC149A2E5" modified="2016-05-11" version="1">MAVNLLGYFSNDIGIDLGTANTLVYLKDRGVVLREPSVVALDTATRKVRAVGDEAKRMLGRTPGNITAIRPMKDGVIADFDVTEAMLRYFIRKVSGSAFRAPPCVVIAIPSGITEVEKRAVKDSALHAGARKVITIPEPMAAAIGVGLPIDEPAANMIVDIGGGTTEIAIISLNGVVFSKSVRVAGDELDSSIINYMKRAYNLLIGERTAEEIKMRIGSAYPLDEELKMEVKGRDSVAGLPKTINITSQEIREALSDTIATIVDAVRITLERCPPELSADLVDRGFVMAGGGALIRGIDRLLSDKTGLPVTIAEDPLSAVANGTGDVLGDLTWLMEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMN1</accession>
    <name>A0A139SMN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711748.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00055"/>
    <dbReference type="EnsemblBacteria" id="KXU35853">
        <property type="protein sequence ID" value="KXU35853"/>
        <property type="gene ID" value="AXK12_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="46427" checksum="3B1E87329B3FF8AA" modified="2016-05-11" version="1">MNYQGLGTKALHAGQQADPTTGSRAVPIYQTTSYVFRDTEHAANLFGLKELGNIYTRMMNPTTDVLEQRIAALEGGTGALAHSSGQAAITDAILNIAGAGDHIVSVAQLYGGTYNLFHYTLARMGIEISFVDAAEPDAFRRALRPNTKAFYAEGLGNPALNIFPMEEVAKIAREAGVPLIIDNTALSPYLNRPAEWGANVVIHSTTKYLGGHGTSIGGVVVDCGNFDWGQNDRFPGFTAPDPSYHGLVYWDAFKAFPPTGGTNVAYIFKMRVQLLRDIGAAISPFNSFLTLQGIETLHLRMPRICENALKTAELLAAHDKVAWVNYPGLKDSPNHAAAKKYLSGGFGGLLGFGLKGGYEAGRKFIESLKLFSHVANIGDARSLAIHPASTTHSQLSPAEQLASGTPPDYVRLSLGTEDFADIQSDLEQALALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMZ8</accession>
    <name>A0A139SMZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="2">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="2">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="2">PII uridylyltransferase</shortName>
                <shortName evidence="2">UTase</shortName>
                <ecNumber evidence="2">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="2">UR</shortName>
                <ecNumber evidence="2">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">glnD</name>
        <name evidence="6" type="ORF">AXK12_00100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="2">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="2"/>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711742.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00100"/>
    <dbReference type="EnsemblBacteria" id="KXU35850">
        <property type="protein sequence ID" value="KXU35850"/>
        <property type="gene ID" value="AXK12_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="5">
        <location>
            <begin position="478"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="731"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="850"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="933" mass="104248" checksum="8C5EF54A95C55A4E" modified="2016-05-11" version="1">MPAEARPTSSPALKFALPDSIDGAARIALCKAFLAERGNALRARHAAGGGGRQIARARADTIDAVLRALMLHAVTGYPHGALPAPMSLLALGGYGRRELCPLSDIDILFLYPSDTPAEAIKPLQEHLIAEVLYPLWDCGLKVGHYTRTIDEVFAEARGDIRTKTSLLEARYLSGSRPLAAHFAEDYRRYFTTEAPLDYITQRLTDQAERRAKAGDTVFLQEPDIKNGVGGLRDYQNTLWMARVKLGISEMAELVGLGYLRGEDAAAFERAYDFLLRVRNGLHFMLTHPSDLMDLAIQPPLATSLGYPQENDLERVEIFMRDYYQRARTILRLSTLVEERLALTLNTGTAQAPKNKKGRTAPLDGFVPRGDKLAAQSPDIFETDPVRLIRVFRHCQSLGCQPDLALAELIRARLPLIGEARLRENRDACESFRAILSEVGDVYPTLDLMHELGVLGAFIPEFGKLTCLVQHELYHRYTVDVHTLRTIRELDQLFATTAEPAALKYRQALHETAAPQLLYLILLLHDIGKGEGVRGHDEAGVRISEPILRRLGISESKTQIALYIIKHHLLMGRFCQTRDLDDPQTAAALAEQVGDPEQLRYLYVHTFCDARGVGDALWNSYKDQLHTTLYRRTMEHMRLGDHEIQARYLARRAAAQADILARQLPDIREDEVTAHFDRLQRRYAIYTEPDEIALHLQMVHRLLHTLVTDAAPQAALRPIIEWQNDLNRSHTIVHVVTWDRAGLFYKLAGALSAAGLSILNAKVHSRSDHIAIDSFTVVEPGRGLVQAPKKRTTFERALRDALLEGRDLYPQIVAEAQKHISPYLLNRDSGPHTAFPPKVEIYHEEATGRTVVEIQACDQIGLLYRLAKTIGEHGYTITWARIATERGIAVDAFYIEQTESDAVRLAALRSALFTIISPNETAPDAADSATAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN28</accession>
    <name>A0A139SN28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">AXK12_04085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04085"/>
    <dbReference type="EnsemblBacteria" id="KXU36016">
        <property type="protein sequence ID" value="KXU36016"/>
        <property type="gene ID" value="AXK12_04085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="93"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="247" mass="26122" checksum="F00FA2F0D46177A9" modified="2016-05-11" version="1">MGRTIAELAPEFGFQVAAALEVGDDLAAGIEAGGETIIDFSFHETTAEVISHAVRFGKALIIGTTGHSIDARASLLKEAAKVPCVWAGNYSVGVNLLNALTQRAAAVLSDDYDAEVVEMHHRFKKDAPSGTAARLLEIILAARGLGPEALRHGREGIPGERTRTEVGIHALRGGDVVGDHTVIFAALGERLELTHKASDRAIFARGALRAAQWIRGKRPGVYDMQDVLGLSEPNGNTAAMSGHSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF8</accession>
    <name>A0A139SNF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711531.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36030">
        <property type="protein sequence ID" value="KXU36030"/>
        <property type="gene ID" value="AXK12_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="71" mass="8406" checksum="E0282912A8DB01CF" modified="2016-05-11" version="1">MTMTSLDLAVNGEVRAWIRGHDRQTRRQQLSRQINPLVKQSANYDSLAHLHEQNRYSRLAARKIWLRRGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH1</accession>
    <name>A0A139SNH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711439.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03935"/>
    <dbReference type="EnsemblBacteria" id="KXU36173">
        <property type="protein sequence ID" value="KXU36173"/>
        <property type="gene ID" value="AXK12_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="319"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="728" mass="80311" checksum="72C640A36FD3C4FD" modified="2016-05-11" version="1">MLALAVAANVQQAPAQNDEEIVRLSPFSINESANIGRYQAVEATSGTRVRVSLMESTQSLSVLTNEFLTDVGTDRLLDAVKYVAGIGEAGNPGLLDAMNIRGFDNYGATMDGFSQFNWTNLDPIVVERIEVVKGPNAIIAPAGLPGGVVNNITKRPLFTNRGYISYQVGRWGANRAELDANYVVQPDKLAVRVVGAFTDADDYGRENFHQSTIVMPMLTYRLGGSTELTLQAQAYNTIAPSNGGTPLSLYAVNRSNIRILDGLPRDFMLPGRPYANRQNGEHVRLSLTSQITDKLSMRLAGSASEINVTNPGFGASLPNVEVIKLDQITGEWSWDGVTRNDSPTYTLGGFKHWVAGHQANFQNDFVYEHTATSWKSQTVVGYAFNYHSQSNRWQLYTPNPTNYDFTKDYTPPGYTLANWLGQVSKRERSSQVYLYQVARLFEDRLVLSGSLSQNRSFSSTKNNLNRDYGEGKKEVMLPSGGIVYNVTPAVSLYYGFSKQETLGNVSSLDAVPPLAVPSRQHEGGIRLKLFDGRLYATLAYFDIVQSNVWSSNPENFITPIPDPPLPSLFADRTAKGVEFEFAWSPTQSLSFIGSFTDYKNRDQDDMPYSNVAERMAAIWGSYTFSEGPLRGLRVGLGASYTGERAGDVGPNFTTPPSGFAPVRIQPSFWVPSYTVVEASASYRFGKHWQATLAVKNLLDRDYIQAAAGSRSIFVSVPINPKLTVRYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ0</accession>
    <name>A0A139SNJ0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711560.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04265"/>
    <dbReference type="EnsemblBacteria" id="KXU36044">
        <property type="protein sequence ID" value="KXU36044"/>
        <property type="gene ID" value="AXK12_04265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014555">
        <property type="entry name" value="RecF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029347">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="362" mass="39369" checksum="778F389A0FCD5F53" modified="2016-05-11" version="1">MISSVAFHNFKALREARVELRPFNLIVGPNGSGKTSLIQALLRLRTLARLHAGGAGTVESVNVERAVLEFRFTAPYEAALARLSCVEQIVCDQIELSGVADSERGALLGKIEGIRAYLFDHYAMAEPSLYTPVEAQSQAGRQREAREKNGSDTLASNGGNLAAALAALHERHPENFAQLEAEFRQIVPEFAGIEVSRRGGVAESGETLELGLRLRGGSGPGGRGEVVTADNLSQGTLYLLAVLFLVFQPAPPSVVCIEEIDRGMHPRWLRALRDLLYRLSYPRDFGQSRAPVQVLATTHSPYLLDLFKDHPEEIIISQKCGLSAHFERLSDRADLGALLGEASLGDLWFSGILGGVPEEEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNL3</accession>
    <name>A0A139SNL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711574.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04320"/>
    <dbReference type="EnsemblBacteria" id="KXU36051">
        <property type="protein sequence ID" value="KXU36051"/>
        <property type="gene ID" value="AXK12_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="291" mass="32214" checksum="D10ECD0C1E54F064" modified="2016-05-11" version="1">MKRTLGLLQHACTSAPAANLEKTLALAEQAARGGAQIICTQELFRSQYFCQSEDHSNFALAEEIPGPSTAAFQALAKKYGVVIVASLFEKRAAGLYHNTAVIIDSDGALLGIYRKMHIPDDPLFYEKFYFTPGDTGFRAWRTKLGKIGVLICWDQWYPEAARLTALQGADILFYPTAIGWHPSEKAHYGATQHSAWETIQRGHAVANGCYVAAVNRIGHETPIGGDGLEFWGQSFIAGTSGQILAKASPDREEVLLHEVDLGSLDVTRTHWPFLRDRRIDAYGDITKRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN0</accession>
    <name>A0A139SNN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711449.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03965"/>
    <dbReference type="EnsemblBacteria" id="KXU36179">
        <property type="protein sequence ID" value="KXU36179"/>
        <property type="gene ID" value="AXK12_03965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="215" mass="23557" checksum="C4E01289C1328167" modified="2016-05-11" version="1">MTATIGKPAPSFSAKAVVNGGEIVSDFSLSRYLDEKYVVLFFYPKDFTFVCPSELHAFQAALSEFESRNTAVVACSTDTEQSHWAWLQVPKAQGGIQGVTYPVVADTNKTISAAYGVLTGEYEFDEDDAGRIALAATAEELIAYRGLFLIDKKGVVRHFLINDLPLGRNVDEVLRMVDALQFFEEHGEVCPANWSRGKAGMKATREGVAEYLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN6</accession>
    <name>A0A139SNN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711471.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03985"/>
    <dbReference type="EnsemblBacteria" id="KXU36189">
        <property type="protein sequence ID" value="KXU36189"/>
        <property type="gene ID" value="AXK12_03985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_8" evidence="1">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="151" mass="17281" checksum="00DD240DE1760984" modified="2016-05-11" version="1">MVNARIARAMSPVKQFSVFAENRVGRLYDLTSLLNTYDVHILALTVHDTIDSAIIRLIVDDRDKTRELLINNDFPYVEREVVVVDLPDESQLKTMLAALLEAEVNLHYFYSFLKRPEGRERLAIHVEEPETAAQALNGRGFKTLSEPDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNT1</accession>
    <name>A0A139SNT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_03630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711332.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03630"/>
    <dbReference type="EnsemblBacteria" id="KXU36239">
        <property type="protein sequence ID" value="KXU36239"/>
        <property type="gene ID" value="AXK12_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299382" evidence="6">
        <location>
            <begin position="30"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="241"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="775" mass="83514" checksum="545596A6F3D9919C" modified="2016-05-11" version="1">MKRNTHLRAVSALPLLALCLVASTPSGFAQRTATDARAETDEAIILSPFEISAQQPARYQAADAASGGRIRTNILNTPSSVTVLTGEFLEDVGSSRFRDAAKYVAGVSESTIPNGHDRVNIRGFQTQGRRIDGFSTFAQANYDSAAVERIEIIKGPDSVLQPAGVPGGTINLVTKRPQFVPGGYVKAQLGQYDANRVEADVTGPFAKGHLAYRVVAAVQDSEGYVKRSYRDSVLVSPSLSWRIAPQSLLTLRYEYLDANVANSEGVPVDPSVGTTTGFKLLEGVPRDFNPAPDKKYSVRGGETHALSFHFSSTITDRLSVRLAGRIGYVDQSEAGFGFGLSTPGGSHNPYTGNWEGGVIWVKTSVDPNPPTFAATPAPALSETFQHFGVHNFANRRERDIQNDWAYIVDGTALKSTTLVGFAYNYFHGNVQTRNEQLPDFTVAGWTKPGAPIEFPISRDTRNVTSRYQVYLTEALELFEGRLVLSGGVSQLSYNGTSGNKLSAANPPFSVAGQMFPGSGNKATYNHGVVVKPLDTLSLYYGHSENAVPAENFEQVSRGNAPVFSQGKQDEFGAKVLLFGGRLIASVAYYEIEQTGYSVYNPANLVSPAPSPLLPDLILSREARGWEFQVTGNITPNLSVIASYDDMKNRDPNGVILRGTPEQTAAAFVRYAVTQGRLAGLAVGIGANYAAKAAGDIPRAGFTGASTPENPIPYQPSFYLPARTIADLYVSYTRGAFVYRVDVSNFTDEAHYGHLSRNNIMVGNPAAVTGSVTFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNV1</accession>
    <name>A0A139SNV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711441.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03940"/>
    <dbReference type="EnsemblBacteria" id="KXU36174">
        <property type="protein sequence ID" value="KXU36174"/>
        <property type="gene ID" value="AXK12_03940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="159"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="362" mass="39780" checksum="DAD8356E1CD2B0F3" modified="2016-05-11" version="1">MTQKSDGMTYAPKGEARHVVKPGEFVFAAAHLDHGHIFGQCNGLSEAGGTLKWVYDPDPEKVRIFLKAYPHAKVAHSLEEILNDSEVRLVAAAAIPNRRGPLGCRVMRAGKDYFTDKTPFTSFAQLEEAQATVLETGRKYMVYFSERLHVESAMYAGDLVHGGAIGRVIQVMGLGPHRLSKASRPAWFFNREEYGGILCDIGSHQFEQYLYYSGAKDATVASAAVGNFANPETPELEDFGEASLVGDNGTSNYIRVDWFTPDGLSTWGDGRTIILGTKGYIELRKYVDVATGSPGKDYVILVDDKGEQKINVEGKVGFRFFGELILDCLNRTEKAMTQAHAFKAAELCLKAQAAARVLTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNX0</accession>
    <name>A0A139SNX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711452.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03970"/>
    <dbReference type="EnsemblBacteria" id="KXU36180">
        <property type="protein sequence ID" value="KXU36180"/>
        <property type="gene ID" value="AXK12_03970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="29"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="32308" checksum="1546BCECCD386A04" modified="2016-05-11" version="1">MNATHPATPRPTLLCFGELLWDFLPDGLFPGGAPFNVAYHLHQHGLDARIVTAVGRDILGEEFLRRIRAWGLPTDTITEHAEFPTGYGRIELSPTGEASYRFANNTAWDHIHVNEAALRAAAAARGLVFGSLALRSPANRSTLDQVLAALPADAWRIFDVNLRPPHDDLPLVNSLAPQATLIKLNAAEAGRLARGGPESPGHEEADARALAARWSANSATEKTICLTCAERGAGLLHNGHWHFEAGRPVEVADTVGAGDSFLAALLTALLIEGKSPAAALAAAARIGEWVATQRGATPRYAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ7</accession>
    <name>A0A139SNZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FeS assembly SUF system protein SufT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711322.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03595"/>
    <dbReference type="EnsemblBacteria" id="KXU36234">
        <property type="protein sequence ID" value="KXU36234"/>
        <property type="gene ID" value="AXK12_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017776">
        <property type="entry name" value="FeS_assembly_SufT_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03406">
        <property type="entry name" value="FeS_long_SufT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="19806" checksum="1185A4AF37D8D578" modified="2016-05-11" version="1">MSTPDTKERVLSRDVAAKQIPSGESQTLVAGTRLFIHQTLGGSYTVQTDFGLFRIDGKDGDALGEQVADHSLEAATLADGSPDPAVVWAQLHKVFDPEIPVNIVDLGLVYSMDIEKNEATGGYRVLVAMTLTAPGCGMGPAIAEDAKSKLLLVPGVDEAEVRITWEPPWNQSMISEEGKMKLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP21</accession>
    <name>A0A139SP21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_03575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711316.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03575"/>
    <dbReference type="EnsemblBacteria" id="KXU36230">
        <property type="protein sequence ID" value="KXU36230"/>
        <property type="gene ID" value="AXK12_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="358" mass="39771" checksum="9E59B02D3A01FE91" modified="2016-05-11" version="1">MIEVQNLTRVFRTYKKQPGFWGGVKGLFKREFEELAAAKDISFSISEGEFVGFLGPNGAGKTTTLKMLSGLIYPTSGTSRVGGFDPSKRESAYRRIFALVLGQKNQLWWDLPAIESFNLLRAIYAIPQAQFNETLDELLDLLDVRAKLNVMVRELSLGERMKMELIAALLHRPRVLFLDEPTIGLDVISQKAVRNFLREYNRRNKVTILLTSHYMADISELCDRVIVIHHGRKIYDGALTSLEHRNEGSASGDVSHSAGVGITRAGGKKKIITFLPELLAQETHSAHGKPQPPAFPENWCSRYGETSRTSDGKFTLRVPADAVVAVSQEILTTGPVADITIEDVPLEEVIADLFSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP27</accession>
    <name>A0A139SP27_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epoxyqueuosine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711263.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03430"/>
    <dbReference type="EnsemblBacteria" id="KXU36349">
        <property type="protein sequence ID" value="KXU36349"/>
        <property type="gene ID" value="AXK12_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="408" mass="45053" checksum="ECACF92F1916C003" modified="2016-05-11" version="1">MTELAAAPIATVEQQERLRARLGELGFDDVRFAALHKLHGKPLREWLEAGMHGEMAWMERSVDKRLDPSQVLSGARSIIMLGVNYWPGRELRQPGPQWARYALWEDYHDTIKAALVEAGRAIEEVFGVGGGDYRYYVDTGPVIERGWAAKAGLGFVGKNAMLISRTHGNWLFLASVLTRVALRPDPPVRKQASNFADVGLLCGKCTRCLDACPTAAFAAPGVVDARRCISYQTIENKGIIPRELRAGIGSRVYGCDTCLEVCPWNRFAERGRQLLLAARHDLPELGLGELLAMTPERFSQVFRRTPIKRLKLRGLLRNACVVAGNQSQAGLSGERLLVARQENERVVAHLLRLAQHELAMIRVHAVWALYRLLGVEAASAALAEIRSAETDAAVLEEYAWWAAASAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP93</accession>
    <name>A0A139SP93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ORF">AXK12_03760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711393.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03760"/>
    <dbReference type="EnsemblBacteria" id="KXU36271">
        <property type="protein sequence ID" value="KXU36271"/>
        <property type="gene ID" value="AXK12_03760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="393" mass="43179" checksum="A60BAEE661C97D3D" modified="2016-05-11" version="1">MRWFGPSDPIPLADIRQTGATDIFTALHEIPYGAEWPQAEIEARRDLIAAAGLRWSVVESVPVHENIKTRTGDFRRYIENYKATLRNLAAAGIRTVIYNFMPALDWIRTDMAHTHADGAEGLLYDPLKLAAFDLFGLARPGAESDFTAEQRAAAATFWDKLGPQGQAAFIRQTLDFFPGLKGQVSLEDLRGMLAPYAKIDAAKLKAHLKLFLEEIVPVAAQVGVNLAIHADDPPFPILGLPRIISTEDDLADLVAMVDSPANGICYCNGSLGARPSNDLPKIARRFASRIHAIHLRTVVHTEGGVFYEGPHLADSAKMAAVVRTLLEETRRRHAAGAPNWQLVFRPDHAHKILDDFRRPEPACPGYPLIGRLRGISELRGLQHGISAMLGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD0</accession>
    <name>A0A139SPD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03480"/>
    <dbReference type="EnsemblBacteria" id="KXU36364">
        <property type="protein sequence ID" value="KXU36364"/>
        <property type="gene ID" value="AXK12_03480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="31263" checksum="94BFAD27BC0EC749" modified="2016-05-11" version="1">MKGAATTSPCDRLRWSALTHRGKVRTNNEDAFIGLCFDGHELHYLGKTGEAPTDTLDFVFAVSDGMGGAQAGEFASRIAIDKLSHWLPRSFKLAASGVALDRTEVLVEVFHAIHAELIQLGRSYEECRDMGATLSLCWVTPHKVFFCHIGDSRIYHLPLRGPLRQLSHDHTHPGWLRRAGKINEREARQHPMRHMLNQVLGAGRQHIEPQAGAVVTEPGDRFLICSDGLTDGLWDHHLDEFARGPIGGENKPVAEHLIAEALDRSGRDNLTAIVIETPDCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPG2</accession>
    <name>A0A139SPG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_03275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711231.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03275"/>
    <dbReference type="EnsemblBacteria" id="KXU36479">
        <property type="protein sequence ID" value="KXU36479"/>
        <property type="gene ID" value="AXK12_03275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="46"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="20680" checksum="F0E1A66A7898F6A9" modified="2016-05-11" version="1">MEKKSPWFRFRVVAYVVIAAIFAFLAYSPNKSEAEEAASASSAAQLSFLGTAPEWELVDLEGAPISAASLKGKVVVVDFWATWCPPCVKEIPGYVSLQQQYGSDDLVIVGVSLDRGKDSEAKVRTFAAKHQINYPLVMGDGDIVDAFASVAGPIQAIPTTFLIDREGNVVHHKVGSMETADYEQLIRAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPG5</accession>
    <name>A0A139SPG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36412">
        <property type="protein sequence ID" value="KXU36412"/>
        <property type="gene ID" value="AXK12_03310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="33787" checksum="641B3C30021ECD61" modified="2016-05-11" version="1">MTPQTPEKEIPVKGYSATQPVVLDAANVSEADLAAAAEAFHRDGYFIARGNFSLEEVEEINSIFAKMHADGGVPGFYELGKLDGWRDEDDRTENRDQVDPLRVWPRVMHAHRFNARARDYFLHPKIRVYVEKFMGTDSVGTQTMYYFKPPGARGQAMHQDNFYILASPGTCMAAWTACDDCDAENGGLMVVPNSQNSDLVCPDTADPNLSYAPHKVPIPKGLKPIPADMKAGDTLFFNGNVIHGSGPNRSKDRFRRSWICHYARGDIAKISEYYAPVVTMDGRDIAVESEKNGGPCGGTWKGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPH1</accession>
    <name>A0A139SPH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03270"/>
    <dbReference type="EnsemblBacteria" id="KXU36478">
        <property type="protein sequence ID" value="KXU36478"/>
        <property type="gene ID" value="AXK12_03270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="287" mass="31649" checksum="236299D5F8576550" modified="2016-05-11" version="1">MPPQLSFLAPVRTEQSKIVFEDASLVAIDKPSGELAALVADGLRRVHNPDPAASGLLVFAKTKRALDFLSGQFQSKSVEQIYHAFCVVLPEPADRPRCATSGGDTHMSLGGLDPSAGVPAEFAIDWWIGSDREAPGRMRAFRRNGGEPALSEFRVLERFGRFAFLECRPRSNRRHQLRVHLAAAGLPVLNDPTYGLLDERLLLSDFKRGYKGVKGSEAERPMITQVALHVSGLTLRHPDSGEALTLHASLPKPFEVALRNLKKYRGSLTRCQRSARPMNAFATPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPI7</accession>
    <name>A0A139SPI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711228.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03260"/>
    <dbReference type="EnsemblBacteria" id="KXU36477">
        <property type="protein sequence ID" value="KXU36477"/>
        <property type="gene ID" value="AXK12_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="307" mass="33826" checksum="9376E79EF871EDC3" modified="2016-05-11" version="1">MNLDPIQDALLASYQRDGGINHLDGVNLPAQDSVNSLAVDVMHLLFPGYFEEAGLTKEQVPQHVRRLLGRIHARLVGDVVKCLRFANENEAEQKAEQRVAEVLKALPELRRIVQTDVVAAYHGDPAAHNVEEIILAYPCVLSISLQRFAHLLHKQAVPLLPRMLTEFGHERTGTDIHPGAQIGTHFFIDHGTGVVIGETARIGNHVKLYQGVTLGAKSFEVDLDGNPVKGIKRHPDIGDHVTIYAHATILGGETHIGQNSIIGSNVWIMNSVPADSVAYYKGENLIVRSRNAQDQFVETAETLHWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ48</accession>
    <name>A0A139SQ48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711155.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36719">
        <property type="protein sequence ID" value="KXU36719"/>
        <property type="gene ID" value="AXK12_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="94" mass="10900" checksum="500668D5E29F8E9F" modified="2016-05-11" version="1">MFTNLARLISRPPPPPSADAPFVLEVNTRSTRARPHNPRTRRFILNCWILIALKHAAVIYACHHWPIPFHQLWINAPTFALGLLATAVYYFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD5</accession>
    <name>A0A139SQD5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711177.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03030"/>
    <dbReference type="EnsemblBacteria" id="KXU36742">
        <property type="protein sequence ID" value="KXU36742"/>
        <property type="gene ID" value="AXK12_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="131" mass="13986" checksum="D4C78CF2C27787FB" modified="2016-05-11" version="1">MKILLKTASTTLAATLLDTPTARDLFAQLPLTLDLNDYAGTEKIAYLPRKLTTHDAPAGSDPELGSVAYYAPWGNLALFYKDFGYSRGLILLGSIEGDAIATLARLPNGKLTLERAGSPSDRSEPDCLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQL0</accession>
    <name>A0A139SQL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">AXK12_02740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711125.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02740"/>
    <dbReference type="EnsemblBacteria" id="KXU36889">
        <property type="protein sequence ID" value="KXU36889"/>
        <property type="gene ID" value="AXK12_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="9"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="425"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="628" mass="69051" checksum="2FF7F8B6E9EE9BD5" modified="2016-05-11" version="1">MIYNKIPYDVIVCGAGHAGVEAALAAARMGAATLLLTGNLDTIGQMSCNPAIGGQAKGQIVREIDALGGEMAINTDLTAIQFRLLNESKGPAVRSPRAQCDKKAYQNRLKHTLELQPKLDLFQALVTDLVFEGDRVVGVRTSFDIEFRAKSVVVTTGTFLRGLMHIGANKTEGGRLGDFTAQTLSGAFLRAGIQLERFKTGTPPRLLGRSLDFAKMQEQRGDAVPTRFAFHDTRAAAGDEAELFHVEQSGESRNGWRVGERPQVSCWMTHTTAETAELVRTNLSRSALYGGEITGVGPRYCPSFEDKVVRFADKPRHLLFLEPEGYSTNEYYVNGLSTSLPFDVQLAMVHSVPGLENAHLLRPAYAVEYDYAPPTQLYATLESKKVGGLFFAGQINGTSGYEEAAGQGLVAGVNAVQKVRGGAPFILGRHEGYLGVLIDDLINKGVTEPYRMFTSRAEHRLLFNHGSAELRLVEHAKEHNLLDNRRIKAIEAKQAAISHWQAWLETNRCEGKTWGELIRRGLEVGALPEEFRRIAPEICDEVLYRVSYQGYLEREQRQIERLRAVDSIKIPPNFDFLGLRGLRGESAQRLAQLRPLTLGQASRISGVNPADISVLMVALGRVAPDIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR6</accession>
    <name>A0A139SQR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02635"/>
    <dbReference type="EnsemblBacteria" id="KXU36926">
        <property type="protein sequence ID" value="KXU36926"/>
        <property type="gene ID" value="AXK12_02635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="678" mass="72281" checksum="01989BACE94E5FD1" modified="2016-05-11" version="1">MDAAHSSQQGHHDHDHSEWRLLTALAAACGGLGLLGFAAAHALPQFPWASHALYFAAILAGAWDAAKDSWENLRARRPIDIHFLMLVVALGAMAIGAWGEAVLLLFLFSASGAMEGYAMDRTQSEISALFKSAPKIALRIDTEGHEAEVPVDELRLGDRVRVKPGALFPADGEVVAGRTSSDESMLTGESVPIDKGPGDAVLSGTLNLWGAVDFTVTQLPSESTLQKVIRLIQTAQKLRAPSERFTQKFGPGYTYGVIAAAGLLFLVWWLGFGVPAFSNTEETRSAFYRAMTLLVVASPCALVLSIPSSILAAIAWGARHGVLFRGGAAIERLARVTAVAFDKTGTLTTGELAVVGCESIPAGREREVLECAYALEANSQHPIARAIVAHAKNAALTLHEIDGFESLTGQGVKAEISPVDERAGLQREARKIKGAATLGRKTLFEGDADFHDWVDQFSPAPEATTEVWLRTEGLVGRILLLDEAREASRPVLRLLRELGLKTVMLTGDRRPAAEAVARKLGLSEVRAALSPEGKVAAIQTLRGEGHQIAMLGDGVNDAPSLAAADVGVAMGARGSDAALEQAELVLMHDKIENFLAALRLSRRAVAVIRQNLVISLGVVGAMVVATLLGVVPLWLGVAAHEGSTFLVVANSLRLLFGRHKEDPPPLLFCEWWRAASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR16</accession>
    <name>A0A139SR16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711098.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02585"/>
    <dbReference type="EnsemblBacteria" id="KXU36920">
        <property type="protein sequence ID" value="KXU36920"/>
        <property type="gene ID" value="AXK12_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="197" mass="21286" checksum="09CCA2CBACE3A7FE" modified="2016-05-11" version="1">MVETGKPVFFVDAHADPVVMRIEGRASFQNSGCLRDFVTEMLAQGKTRLVIDFQHCTSMDSTFLGILAGVALQLRKGNAGGAAAGGAGGQGGERGVTGALRGGKSESSQPLILARVGQRNLELIRNLGIHRLMTVDSGDFKMNFDHCARPLTQQEQDELSNARMALEAHENLVAADESNRSKFQDVLSFLKNRVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR53</accession>
    <name>A0A139SR53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711033.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37079">
        <property type="protein sequence ID" value="KXU37079"/>
        <property type="gene ID" value="AXK12_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="62" mass="6768" checksum="AC7518E928AAB2F5" modified="2016-05-11" version="1">MKDKLHLPSLIAGLLAATLLIYLGSLVSVSIDMIVAYGSVVMMMVLTSYDYLSPRRKHAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR75</accession>
    <name>A0A139SR75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">AXK12_02425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007360011.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02425"/>
    <dbReference type="EnsemblBacteria" id="KXU37037">
        <property type="protein sequence ID" value="KXU37037"/>
        <property type="gene ID" value="AXK12_02425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="41" mass="4799" checksum="8313CA81925332A0" modified="2016-05-11" version="1">MKVVSSIKSAKKRHPDCQVVRRKGRIYVINKTDPRYKARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR78</accession>
    <name>A0A139SR78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711040.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02260"/>
    <dbReference type="EnsemblBacteria" id="KXU37086">
        <property type="protein sequence ID" value="KXU37086"/>
        <property type="gene ID" value="AXK12_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="340" mass="36305" checksum="84DDD2D2C5B0948B" modified="2016-05-11" version="1">MKTRILGQFNGGLEVSALGLGCMGLDFGYTHNGDVSQEAGAALLRGAVDHGITFFDTAEVYGPYTNETRVGAALAPVRDSVVIATKFGFRYEGGKNVGLDSRADSIHRAVDGSLKRLGTDYIDLLYQHRVDPSVPIEDVAGAVKELIEAGKVRHFGLSEAGVKTVRRAHAIQPVTALQMEYSLWFRDVETNGILATAEELGIGLVPYSPLGKGFLTGALSGASLPASDFRKALPRFADEAIQKNRALVELIQRVAATKRATPAQIALAWLLAQRPWVVPIPGTTKLQRLEENLGAAAVELSAAELAEIARAAAAIPIEGARYTPDQLARVGIDAPERTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRD3</accession>
    <name>A0A139SRD3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="11">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DHOdehase</fullName>
            <shortName evidence="11">DHOD</shortName>
            <shortName evidence="11">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrD</name>
        <name evidence="13" type="ORF">AXK12_02325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cell membrane</location>
            <topology evidence="3 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711051.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02325"/>
    <dbReference type="EnsemblBacteria" id="KXU37097">
        <property type="protein sequence ID" value="KXU37097"/>
        <property type="gene ID" value="AXK12_02325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="12">
        <location>
            <begin position="60"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="352" mass="37716" checksum="5F317AC60C1D5D9F" modified="2016-05-11" version="1">MGWFYEKCLRPALFRLDPEHAHELAVDALAVLARVSPLCRAMEAWHGRDAERLSLAGQPVQCFGLNFPNRVGLAAGFDKNARAWPAAAALGFGHVEIGTVTLLRQPGNGRPRVFRFPEQEAVINRMGFNNEGAESVALRLGRQPVPGARAIPLGVNLGKSKLASLDQAVNDYLGSFALLADYADYLVLNVSSPNTPDLRKLQDEERLRELLAAVTDANRRRAESPGLRAKPLLLKIAPDLNAPQVDSVLELVTEFGLAGIIATNTTLERPPGPLADAAQAGGLSGAPLRERATEIIRYIAKATDGRLPIIAVGGITDSASAIEKLDAGATLIQLYTGLIYRGPFLAAQIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRK1</accession>
    <name>A0A139SRK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711009.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02100"/>
    <dbReference type="EnsemblBacteria" id="KXU37229">
        <property type="protein sequence ID" value="KXU37229"/>
        <property type="gene ID" value="AXK12_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="454" mass="50221" checksum="58A4C582BBD7E996" modified="2016-05-11" version="1">MKLIDLNREGGIGANCLLLELAGLRILVDCGLNPKQVGRAATPDLARLRELPLDLIIITHCHLDHIGSLPVVMREHPSTPVIMSSSSRLLIERMLRNSASVMKRQKEEENIPDYPLFSHAEIERLRGRMMGLAFGQAKRFRGHHSGSEIELIFHPAGHVAGAAGVELVHKHRHIFLTGDVLFEDQRIVPGAKFPSGHFDTLVMETTRGDTDSSDIALRGDEFARLVKSINDTIQRGGSFLIPIFALGRMQEVLTVINDARKFGRLVDCPIYASGLGMDLVDYFDEISRKTRHIHFNRSIVKDLQLQPLPRKLEAGKDPQQNALYIISSGMMVEKTPSNTLASGLVGHARNTIGFVGYCDPDTPGGQLLASKPGDSFLFEKAGVKTKVKARVERFELSGHADRDHLLQFAVQAAPRAIVLTHGDAPARKWFSNQLTEQLPNAKVIDPTPGEEYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRZ7</accession>
    <name>A0A139SRZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710962.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01875"/>
    <dbReference type="EnsemblBacteria" id="KXU37375">
        <property type="protein sequence ID" value="KXU37375"/>
        <property type="gene ID" value="AXK12_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="240" mass="25812" checksum="3567C176A9D1A9AD" modified="2016-05-11" version="1">MKQSLSGKFAAITGATSGIGLATARTLIKAGATVVFIGRNEQVLNEVCDGRSALPLVADLSQPEHCEQLADRLLTLVPHIDIFHANAGVYVGGDLINASLEQIDQLLQVNVNAVIKNVRSIMPHMMERKTGDIIITSSLAAHCAVAWEPVYSASKWAINSFVQVMRRQLLPYGIRVGAVSPGPVDTPLVSDGPEGTLKQAKANGSIIEADLVADAILYMLTRPRCMTIRDMVIIPSRFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS55</accession>
    <name>A0A139SS55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02065"/>
    <dbReference type="EnsemblBacteria" id="KXU37416">
        <property type="protein sequence ID" value="KXU37416"/>
        <property type="gene ID" value="AXK12_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="272" mass="30067" checksum="90BE411C4D939B5C" modified="2016-05-11" version="1">MPHQVKSPKAAAPILNVSDLHIRRGKTVILERVDWRINRGENWVILGANGSGKTSLLRALTGYFPPTRGEIELLGGQYGNCDWRALREHIGIVTTSFTSLIPPAEPALETVISGKFAQLDLWKKVTKVDCSAARKLLALVDGSYLETREWQFLSQGERQRVLIARALMARPRLLILDEPCAGLDPVARVEFLKLVDRLARSPRAPALVFVTHHVEEITPAFTHALLLRKGGVVAAGTRARTLNSEKLSQVFAAPVRLSRSATHGLRLDIQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSB0</accession>
    <name>A0A139SSB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01940"/>
    <dbReference type="EnsemblBacteria" id="KXU37412">
        <property type="protein sequence ID" value="KXU37412"/>
        <property type="gene ID" value="AXK12_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="235" mass="25156" checksum="FA1DA3EB6CE1F3AC" modified="2016-05-11" version="1">MPSILAPSLLAGDHAGLAASAAQVAAVGLHWLHLDIMDGHFVPNLSFGPETLAALRRAEKENARSHTSPTSELQVNESKTFFDTHLMLSEPQRYLKAFAAAGADLISIHIEPDYDHASALAEIRSLGCQCGIVLNPDTPAEAVRHLLADVDLVLVMTVQPGFGGQSFRPAMLEKLKTLDGWRRENGWQWRLEVDGGIGLSEASACRAAGADTFVAGTAFFKAPDLAAFARSVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSS3</accession>
    <name>A0A139SSS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710887.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37635">
        <property type="protein sequence ID" value="KXU37635"/>
        <property type="gene ID" value="AXK12_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299409" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="60" mass="6530" checksum="0B097C71023CE297" modified="2016-05-11" version="1">MNLKPRHLAALFLLALGALFSSGCKTLEAIGSAIPSSYPAYGYEEEYLPEPEPIITRGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU9</accession>
    <name>A0A139SSU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01610"/>
    <dbReference type="EnsemblBacteria" id="KXU37665">
        <property type="protein sequence ID" value="KXU37665"/>
        <property type="gene ID" value="AXK12_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="108"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="238" mass="26165" checksum="90C504F3BE9C93FE" modified="2016-05-11" version="1">MPLPELPNRLLETVQAERPQERLEREGAGALSDTELLAMLLRSGTQGMDVLSLAARLIEEAGSLAGLTEWLEDDFRRFKGVGRVKALQLLTVMEVAKRILRQSQGESPRIESGERAAAYLAPLAVGLRVEKFWVLSLNARQHLIRCRELSSGTVEGTLAHPREVFRIGIRDGASALVVAHNHPSGDPTASPTDLQLTAKLRDASHVVDIPLLDHIILGTKTADPLQRGYYSFRELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSV6</accession>
    <name>A0A139SSV6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome-c oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710904.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01580"/>
    <dbReference type="EnsemblBacteria" id="KXU37653">
        <property type="protein sequence ID" value="KXU37653"/>
        <property type="gene ID" value="AXK12_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014116">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_FixG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032879">
        <property type="entry name" value="FixG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13746">
        <property type="entry name" value="Fer4_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11614">
        <property type="entry name" value="FixG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02745">
        <property type="entry name" value="ccoG_rdxA_fixG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="493" mass="54712" checksum="34112BAC4B101AD6" modified="2016-05-11" version="1">MLKPVRPTIDSVTTISADGSRPFIYPADVKGRFTTARKLSALALIVFYLSLPWIQVGGFPAVFLDIAARRFHLFGLTFAAQDMWLSFFLITGLGFALFFITALFGRIWCGWACPQTVFLDHVYRRIERWIDGNAVARRKLAAAPWTGAKIAKRTLKHALYLLVSLVITHLFLAYYVSLKSVWEMVSTAPGEHWSAFLFVAVATAILYFNFAWFREQLCIVICPYGRLQSAMIDDHSMVVGYDTRRGEPRGKGAKPGLAKSPNAAAGSVEFVKTGSSSEPEAKRGDCVDCARCVQVCPTGIDIRQGLQLECIGCTACIDACDEVMRRLKRPTGLIRYDSQAALAGARTRWLRPRVYLYSVMLAIGIGVASKAISTVKPANISVTRITGTPYVVTDETIRNQFFVRILNKRAEPTDFIVEVDSPTPLTRSGLDGPLSVPAISEEIRPLVLVVPRSHYTGPFKVSITTRDAQGRFAQTREIEFLGPDPRLLNEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST25</accession>
    <name>A0A139ST25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lpxK</name>
        <name evidence="16" type="ORF">AXK12_01445</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710883.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01445"/>
    <dbReference type="EnsemblBacteria" id="KXU37631">
        <property type="protein sequence ID" value="KXU37631"/>
        <property type="gene ID" value="AXK12_01445"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="476" mass="52260" checksum="35F972E240EFAB69" modified="2016-05-11" version="1">MSSWLKRKITALELYTIDVILGRRADAGAVIYGAFLELLSYLFSGIAQLRLWLYRQRILHDQPLGCLVVVVGNLTVGGTGKTPVVEKFARALQARGRRVAILSRGYKSKAPPLWRRWWWAISHTAAPPPRIVSDGEQLLLDSEEAGDEPYMLARNLPGVIVLVDKNRVKAGAYAIKRFGCDTLLLDDGFQYLPLKGQLNLLLVDKTNPFGNSHLLPRGTLREPIKHLRRASYVFLTKSNGERDAELEAIIERYNPGVDIIECTHQPQYLQRLGAKRRASAASGGFPSVGSHAIAERGAPASVADSVKKATGAAEGLAPSSRVAIAAEDSPSSQSRAAAAETHAAVAADQQQPLSFLKGRRVAAFCGIATPESFFKFLTDYGAELVARERFPDHYRYAEADFVELAALAQRTGAECLITTEKDAVRIPYERAWGCPVYYLRLEIDILRGAADFDEAVSRICFPEGATRPQPLSSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST52</accession>
    <name>A0A139ST52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ORF">AXK12_01480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710913.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01480"/>
    <dbReference type="EnsemblBacteria" id="KXU37661">
        <property type="protein sequence ID" value="KXU37661"/>
        <property type="gene ID" value="AXK12_01480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="577" mass="60446" checksum="CF799C18C90D07BB" modified="2016-05-11" version="1">MSKSSSAAETIRPHSSAVVDGNDRAAARAMLRAVGFTDADFKKPQIAVASSPSDMTPCNVHLGDLSDHARQGIAAAGGKPVYFNTITVTDGISMGTQGMRYSLVSREVIADSIETAVAAEGFDGLVAIGGCDKNMPGAMIAIARLNRPAVFIYGGTILPGFTADDCDHKKPLDVVSVFEAVGKHAKGELDDAGLKAVEAAAIPGPGSCGGMYTANTMASAIEVLGMSLPNSSAQLAVSEAKRQDCERAGEAVMNMLRKGIRPSDILTRKAFENAITVCIALGGSTNLILHLLAIAHAAKVSLSLEDFREIGERVPLLADLKPFGKYNMSHLVRIGGIRPMMKLLLDRGMLHGDCLTVTGETIAETLRDVQPYAAYPHEQDIIHPWEQPIKSSTHLRVLHGNLAPGGAVGKITGKEGLYFKGTAKVYEGEEDALKGILRGDVVKGDVVVIRNEGPCGGPGMREMLSPTSAVAGRGLIKDVALITDGRFSGGSHGFDVGHITPEAAKGGPIGIVRNGDLIEVDAVKNTISLLIPDDEYAARMAAYRPAPPKETRGVLAKYAALVATASEGAVTDKALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST97</accession>
    <name>A0A139ST97_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NDP-hexose 4-ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710822.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01130"/>
    <dbReference type="EnsemblBacteria" id="KXU37796">
        <property type="protein sequence ID" value="KXU37796"/>
        <property type="gene ID" value="AXK12_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="850" mass="94031" checksum="189136BD9117A4A2" modified="2016-05-11" version="1">MSQQDPTNNFTPRAQQVLAMSKQEAARYKHNYVGTEHVLLGLISLDEGVAVSVLQKMGINLESVRAEIEKQVGTGPGEGAPNPIPYTPRVRKVLALAAKEAKTLKHSYIGTEHLLLGLLREGEGVASRVLKELDIDIERTRQEILKELDPQFSGDGAGDNADGPSMAAAGGPGDDPRNNTVKTPALRAFGRDLTEIARKGELDPVVGRQNEIRRVVQILCRRTKNNPVLIGEAGVGKTAIAEGLAQEIAIGAVPDILSEKRVITLDLALMVAGTKYRGQFEERIKAVMDEIRRAKNIILFIDELHTIVGAGGAEGAMDASNIFKPALSRGELQCVGATTLNEYRKYIEKDAALDRRFQSVKVEPPSVEDTITILKGIRSKYEDHHKAVFTDAALEAAAKLSERYITGRFLPDKAIDIMDEAGARARINSMVRPPNIEELNAKIEAVCAEKEKAITGQLFEEAAKYRDEEKQLRTQLDEITATWRKERDEQRVTIDEDLMMEVVSTWTGIPLTRMEQKETKQLLSIEAEIQKVVVGQDLAASAIARALRRSRVDLKDPRRPIGSFLFVGPTGVGKTETAKQVAVQMFGNQDAIIQVDMSEYMEKFAVSRLVGSPPGYVGYDEGGQLTEAVRRRPYSVVLFDEIEKAHPDVIQILLQILEEGRLTDSLGRTVDFRNTIIIMTSNIGAALLQRQTSMGFAAAAANPNDADKMREKVIEESKRVFKPEFLNRISDIIFFRPLEKTDLVKIVDIELEKFGKRLAPRAITIEFTKPAKELLIDKGYDEKYGARPLRRAIENSLEDPLAEAILKGEIKDGDSVRVDRDGEKLIFKSAAKRKPRGAKPAAPADPELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB0</accession>
    <name>A0A139STB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="7" type="ORF">AXK12_01395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710866.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01395"/>
    <dbReference type="EnsemblBacteria" id="KXU37838">
        <property type="protein sequence ID" value="KXU37838"/>
        <property type="gene ID" value="AXK12_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="334" mass="35709" checksum="ACA98B755DC05338" modified="2016-05-11" version="1">MNLTLVIMIAAVVAGLIVLGIVISFFNVWLKAWLSGAYVSLVNLAMMRLRGVPYGIMVEARIRAVKAGIQLEINEIESQYLAGGNVIACVQALIAAQKARIELDWQRACAIDLATKGSGKSVEEAVRTSVDPKVIDCPNPEGGRTTIDGVAKDGIQVKVKARVTVRTNLDRFVGGAKEETVIARVGEGIVTTIGSADSYKVVLETPDSISKTVLSRGLDVGTAFEILSIDIADVDVGDNVGAKLQEAQAEANKNMAQAQAEIRRAAAVALEQEMKAKVQEMQAKVVAAKAEVPLAMADAFRSGRLGVMDYFRMENVQADTDMRKSISSDNGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC1</accession>
    <name>A0A139STC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37829">
        <property type="protein sequence ID" value="KXU37829"/>
        <property type="gene ID" value="AXK12_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="137" mass="15279" checksum="A4318AB1BCC43068" modified="2016-05-11" version="1">MISSLVVEGKGALDFGSEDSDYGHGPRFLLLDDLVIGNNSTLQISDWQDGRDHLLVRKYSQHLEDALKKIEFLGYDRSSVHIKAPHTGDYHKDKDYWEISATYVPEPATYGGFLVAGTVSLSLLRRRLKACLGRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC2</accession>
    <name>A0A139STC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710853.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01305"/>
    <dbReference type="EnsemblBacteria" id="KXU37827">
        <property type="protein sequence ID" value="KXU37827"/>
        <property type="gene ID" value="AXK12_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="229" mass="25114" checksum="755765E4D7D6A832" modified="2016-05-11" version="1">MDTLLLWDIDGTIIKGHGAGVRAMERGFEKSFGRAGQKCDLGVVDWAGRTDKWITRAVLEHFGWAATEENVQRYLSAYMEALAEELAVGPGEILPGVIELLDTLHAHPRVAQGLLTGNLRQGAQLKLGHYDAWHYFPFGAFADDSGVRNELGPYALRRAHEQHGVHFTPERCFIIGDTPHDIECARVIGANAIAVATGTYTLAELETHKPTLSLANLADTELFLKTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC3</accession>
    <name>A0A139STC3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710841.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01240"/>
    <dbReference type="EnsemblBacteria" id="KXU37815">
        <property type="protein sequence ID" value="KXU37815"/>
        <property type="gene ID" value="AXK12_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="322" mass="33927" checksum="A8441C3052152087" modified="2016-05-11" version="1">MTAPTVENLVIIGTGCAGLTAAIYAARANLNPLVLEGAQPGGQLTTTSEVENFPGFPNGVDGFQLTQNMREQAARFGTRFEQAQVSGVDFTKMPRELHLGGANGSQAGRTLLAKTVIIATGASPRMTGVPGEKEFYGGKGVTTCATCDGAFYRGMPVAVIGGGDSAAEEALFLTRFASQVFLIHRRDSLRASKIMADRATSHEKITMVWDSVPLEVLGDDTGNVSSLKLQNVKTGEESTLPVKGVFVAIGHIPNSQAFAGAVEVDEARYFKTQPGSQVRTNIPGVYVAGDCSDHVYRQAITAAGMGCQAAIDAERWLAEHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STH0</accession>
    <name>A0A139STH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710840.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01235"/>
    <dbReference type="EnsemblBacteria" id="KXU37814">
        <property type="protein sequence ID" value="KXU37814"/>
        <property type="gene ID" value="AXK12_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03858">
        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="338" mass="36623" checksum="DD670647C9BDBB27" modified="2016-05-11" version="1">MQIGVDSFVSTSKRGAVGDAQRVQDLLEEIELADQVGLSSFGVGEHHRPDYVSSAPAVLLAAAAARTSRIRLSSAVTVLSSDDPVRVFQQFATLDLISQGRAELMVGRGSFIESYPLFGYDLNDYNTLAAEKLGLLLKIRDSEHVTWSGRHRAPLSGQGVYPRPLQQPLPIYVGVGGSPESVVRAAKLGLPLAIAIIGGSPRQFRPLADLYRQTWAEAGRTPETCTIAIHNLGFLADTTEQALDTFWPAYREVFGGIGRERGWAPPSRPQFDAQCGPLGALQVGSPEAVAEKLANEHQWLGGISRVNLLLDNRVLTHAQIMRSIELLGTKVAPLLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STK3</accession>
    <name>A0A139STK3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_01100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710817.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01100"/>
    <dbReference type="EnsemblBacteria" id="KXU37790">
        <property type="protein sequence ID" value="KXU37790"/>
        <property type="gene ID" value="AXK12_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="59"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="410"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="630" mass="70447" checksum="87FFE5BA7960B21A" modified="2016-05-11" version="1">MITPTDTGLESDSSAATPAPAAAATSASALAADAALRTSPTDFIRDIVAAHVAENRYPQIVTRFPPEPNGYLHLGHARAICLNFGIARENAGRCHLRFDDTNPAKEDAHYVAAITRDIRWLIHDWADAQLTFKPRGAGPAAHRSADGHPDHLVPHAPADAPDTEPYAASDYFDALYDYALELIRRGKAYVCDLSPEDTERYRGTPTTPGQNSPYRDRSVEENLDLFARMRAGEFPDGARTLRAKIDMASPNLWLRDPLLYRIRHITHHNTADRWCIYPLYDYAHCLSDYLEGVTHSCCSLEFVAHRPLYDWVLDSLDLPRPRPYQYEFAKLIPSYTLMSKRNLLRLVKERAVNGWDDPRMPTLAGLRRRGIPAAALRRFVIETGITTHDGGLTDIALFEHTLRDELNKTAPRRLAVLHPLKLILTNLPEGEVIPCQATNDPQNDAPSTRTVSLTREVFIERDDFAEVPPPKFHRLKPGGEVRLKYACIITLDEIVKDPATGAVTELRATAQLDTRAGQPNSNKKVKGTIHWVSAPESIEAEVRLYERLFTVPEPAAEDDFLKVLNPHSLETVYGARLEPALASAQPNEPVQFERLGYFTLDVAENEDAAADGDARLIFNRTITLRDTWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STK8</accession>
    <name>A0A139STK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710838.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37812">
        <property type="protein sequence ID" value="KXU37812"/>
        <property type="gene ID" value="AXK12_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="140" mass="15123" checksum="270AB9D0ACED20C9" modified="2016-05-11" version="1">MASRTKKNSSASAVAPPVTFDLPEELLARLERNRVSAGLRTTSEMIRAVVDGFDFESCTLPVEGARRQISVRLSPEQRAMLKRTAARKGRSIGELLRFAVEALPVPKGSAKAKAAPKAASEPKKKAAPEKKPSAKSRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN8</accession>
    <name>A0A139STN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinate-nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00955"/>
    <dbReference type="EnsemblBacteria" id="KXU37957">
        <property type="protein sequence ID" value="KXU37957"/>
        <property type="gene ID" value="AXK12_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="528" mass="59226" checksum="B1CE968311B56320" modified="2016-05-11" version="1">MPMEGAASPDSQDLLTTHRKALRINLDATKYGTFAEIGAGQEVARVFFQAGGASGTVAKTISAYDMTFSDAIYGKAPRYVSQERLLLMLDHEFELLRERLSESRGTKTQFFVFADTVSARNFAGTNEQHGWMGIRFQPAPCAEPSEIVLHVRMSDTEAVLQQEALGIIGTNLVYAAFYYRNDPQKFTASLLDHLSPTRIEIDMLEFRGPEFAHIDNRLTSLLLVHYGLTNAVMFGPGGSVLQPSEVLRKKAILVERGSFRPVTHVNVDMLHCAAAQFIQEPLVKDRDFIVLTEITVHNLLADGQFDSADFLSRVDLLGAIGFTVLISNYSEFYRLTAYFRRYTKEMIGMAMGITNLLEILNEKYYENLEGGILESLGRLFRHSVKLYVYPMLREPYECYLATGQTSEPTTDSAAPPTGERQNGSGSTPRDARLTEAHKIETVTAQNIQVAPHLRNLYAHLYENCYIECLTGYNPDILHIFSREVLRRIQDQDPTWENLVPDSVAAVIKARQLFHYQAPQQPSTLVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ8</accession>
    <name>A0A139STQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_01065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710808.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01065"/>
    <dbReference type="EnsemblBacteria" id="KXU37977">
        <property type="protein sequence ID" value="KXU37977"/>
        <property type="gene ID" value="AXK12_01065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="PTHR11374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="10">
        <location>
            <begin position="328"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="263"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="458" mass="49396" checksum="5BE9706DD74C80E7" modified="2016-05-11" version="1">MKICCIGAGYVGGPTMAMIAKQAPDIEVRVVDMNAARIAAWNSAKLPVYEPGLDEVVQECRGRNLFFSTEVRAAIREADIIFVSVNTPTKTYGLGAGRAADLRYIESVARTVAEEARGPKIIVEKSTIPVKTAGTIQTILAANARPGVAFEVLSNPEFLAEGTAVADLLAPDRVLIGGERTPSGERALQTLVDVYARWVPRERIVTTNLWSSELSKLVANAFLAQRISSINSISALCEATGADVDEVANAIGKDSRIGPKFLKASVGFGGSCFQKDILNLSYLCEHFGLPEVAAYWQGVVEMNDWQKRRFTSRIVNALFNTVADKRIAVLGFAFKKDTNDTRESAAITVCRDLLGERAQVVVYDPKVSAEEIRRDVGGPSAGDDCDRLQIASSAAEACAGAHAVAVLTEWDEFKTLDFGAIYAGMSKPAFVFDGRNLLDHAALREIGFRVEAIGKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STX3</accession>
    <name>A0A139STX3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710795.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00990"/>
    <dbReference type="EnsemblBacteria" id="KXU37964">
        <property type="protein sequence ID" value="KXU37964"/>
        <property type="gene ID" value="AXK12_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018759">
        <property type="entry name" value="BBP2_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10082">
        <property type="entry name" value="BBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299431" evidence="1">
        <location>
            <begin position="28"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="381" mass="41698" checksum="DD99B208D0585A7A" modified="2016-05-11" version="1">MMKITSSKLAVPVAALLGLFATTPGYSLVTFNDGQNSIFVNVSTGMSWDSNINSSADTTSDHIWFANVGVNFSRRAGIISIDANATANISRFNNHSEENFANPDMSLSLSKHTGRTTGTLSLSGARQNRADSAANIRNESWYYNAQGSLKYPIISRYSLTFGGGFHERTFRNAPGYLVDDRVTNWSTGLNYAYTDQTDLTASYRGRYGETSAHDSYYDHAFLVGVNGKILAKLTGSFHMGYQQRNNTKKWQGSHSSLTMSGSANWRISPKFNAAFFISKDFSVASTNIHTDTLSAGTNVSYSLTPRFSVNGGINGGESRFLGLGGGGRKDQFFGANVGASYAVYGDYLRLHLGYNYFRNWSNTAISDYDRDSLSLSASSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STY5</accession>
    <name>A0A139STY5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">AXK12_01050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710805.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01050"/>
    <dbReference type="EnsemblBacteria" id="KXU37974">
        <property type="protein sequence ID" value="KXU37974"/>
        <property type="gene ID" value="AXK12_01050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="675" mass="73540" checksum="3D45FF53E105B2F3" modified="2016-05-11" version="1">MPDSDNKKSRRPLKNLPPDRFQPKVLLIWLLVALTLTSLLLWSPARLGSPITLKIQQVVELAESGGIKEGVIKPDLSGGRDWSLVTGELSEPMLLRPDSEQTTTAFRSAGRLTDSNLERLQRSARFVEQPATTMWSQILANVIPFVIIIGLLYFLFIRQLKQAGRGALSFGKSKAKLLTRDKEKITFADVAGCDEAKEEISEIVEFLKAPKKFSAIGGRVPKGMLMVGPPGTGKTLLAKAVAGEADVPFFSISGSDFVEMFVGVGASRVRDMFEQGRKNAPCLIFIDEIDAVGRQRGAGLGGGNDEREQTLNSLLVEMDGFSTQDGVIIIAATNRPDVLDSALLRPGRFDRQVTVDLPDIVGREAILRVHAKKITLAEGVDPALIARGTPGFSGADLANLLNEGALLAARRNKEKVEMIDIEDAREKVLFGREHRRLMDESEKRLIAWHEAGHAIIQGLLDDGTMPVHKVTIIPRGQSLGSTTYIPTKDILTRPMKKLLDQIAMAMGGRIGEELVTGDFSNGASGDIKQATKIARAMVCDYGMSALGPVDLAENQDTVFLGRDITRSRHISEDTARKVDEEVTRILKEQYARAKELIYSHRAALDKIAEALLEYETIEGKHILEILAHGEIKSAVIVSPPPKPKPAPTLAEEGTTAQETEPVMPSLEGTPAPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STY7</accession>
    <name>A0A139STY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710754.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00770"/>
    <dbReference type="EnsemblBacteria" id="KXU38068">
        <property type="protein sequence ID" value="KXU38068"/>
        <property type="gene ID" value="AXK12_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="36990" checksum="4CF469AC3DCEF9E9" modified="2016-05-11" version="1">MTATPNLETARKLLCALQDHIRDTLVAARAKSGASFARIAAVTAADTIYEVDKITEDAIFEWFDLHWPRKWPVQLVMEGIEDDEVVTFPRGLRVDQTMFVCIMDPIDGTRNIMYDKRSAWALAALALQRGAKTGLGDIVVAAQTELSTSKMWRSDQLSAVRGKGVVARAFDLRERRWSRLSPRPSRATDFEHGFASIARFFPEGKGLLGTIEEALWSELGILGKNGGQLVFDDQYICSGGQFYELLIGHDRMLGDLRPLVYAKLGLAGGALCCHPYDVCTALILEEAGGIVETPEGRPLRAPLDTTSPIAWMGYANATLAKKVRPILKRLLKAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU02</accession>
    <name>A0A139SU02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transporter ExbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710769.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00830"/>
    <dbReference type="EnsemblBacteria" id="KXU37940">
        <property type="protein sequence ID" value="KXU37940"/>
        <property type="gene ID" value="AXK12_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="140" mass="15196" checksum="C759F4A9483AB6BC" modified="2016-05-11" version="1">MTGGTQGGGPKKARIEIIPLIDVIFFLLATFILFTLSLNTPGGLRVALPRSETGEPRDPSNSVTITVTDEGTLAWDKDPVTLDEFLVRLQTYVASEASPKVLINGDENAFFSQAIYVFDEVRKAGVQKVLIETRLAKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU29</accession>
    <name>A0A139SU29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="7" type="ORF">AXK12_00745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710751.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00745"/>
    <dbReference type="EnsemblBacteria" id="KXU38065">
        <property type="protein sequence ID" value="KXU38065"/>
        <property type="gene ID" value="AXK12_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="316" mass="33685" checksum="655D756A402654DD" modified="2016-05-11" version="1">MIGLFKKFKDGFAKTVAAIGATTRGLFGGRRIDAASLEQLEEALYTADFGVETTTEILDEIRAAYRKDPELRGAQAAEIGAAVLARVLAGAEGSLGTPAQNEAEGRLPTVIAMIGVNGSGKTTTTAKLAWRLKEEGQRVTLAACDTFRAAAVEQLKSWATRLDLDLVASHTGADAAAVAYDAWAAAKARGSDTLIVDTAGRLHTKSNLMEELAKIARVLQKHDPSAPQHRWLVVDGSLGSNSIEQARVFHKHFGLTGLVLTKLDGTSRGGAIVGIWRELRLPIYFVGLGEQPEDLQPFSVENYARAVFGCDAGTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHE7</accession>
    <name>A0A139SHE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_08155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713263.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08155"/>
    <dbReference type="EnsemblBacteria" id="KXU33998">
        <property type="protein sequence ID" value="KXU33998"/>
        <property type="gene ID" value="AXK12_08155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="23281" checksum="F5F0D7CA1758B6FE" modified="2016-05-11" version="1">MTRLEQQIRFIIEADKLKEITRQTLTSQSRRAENTAEHSWHFALMVMTLAEHAIGELGQPLDVLRVLKMALIHDLVEIDAGDTFAYDEVNRTDQHAREARAADRIFGLLPEDQAREYRALWDEFEAQETPEARFATACDRLNPILLNTLTGGAAWQKHGITQDRVLERNAHIAAGSPALWDYAKSIIKETFSASAPCGTDSHARTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG4</accession>
    <name>A0A139SHG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">AXK12_08080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713241.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08080"/>
    <dbReference type="EnsemblBacteria" id="KXU33986">
        <property type="protein sequence ID" value="KXU33986"/>
        <property type="gene ID" value="AXK12_08080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="437" mass="46028" checksum="18D5D5517BD9F336" modified="2016-05-11" version="1">MKDNERFSPNPIEAQPTSLFARAEKRIPGGVNSPVRAFRSVGGTPFFVRSAQGATLTTEDGRELIDFVCTWGPAIHGHNHPRIRAAIADALTRGTSFGAPHAGEVELAELITKFFPSIQKVRLCSSGTEATMSAIRLARGFTGRDRIIKFSGCYHGHSDSLLIKAGSGALTHGHPDSAGIPAAFARETLVLPYNDCSALDAVFTAEPDTIAAVIIEPYCGNVGFIIPDPGYLAHLRKLTAKHGTLLIFDEVMTGFRLAPGGVQELEAITPDLSCLGKIIGGGLPVGAFGGRSDIMDALAPSGPVYQAGTLSGNPLAVAAGIAALLLLEELNPYAQLDTLGRQLRDAALAAARAKGIPLQVPQCGSMFSLFFNAEPVRDYANALKSDAALYARLFHAALARGVYLAPSAYEAGFISTAHAGEAIDRACEQISAAIHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ4</accession>
    <name>A0A139SHJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">AXK12_08110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713251.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08110"/>
    <dbReference type="EnsemblBacteria" id="KXU33991">
        <property type="protein sequence ID" value="KXU33991"/>
        <property type="gene ID" value="AXK12_08110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="144" mass="15643" checksum="2237D60DE145B77B" modified="2016-05-11" version="1">MKTIAILHGPNLDRLGKREPQVYGHATLADLEAFIRTEAEQRGFATRFFQSASEGALVDKIHSLTDSGVAGFIVNFGAYSHTSIALRDALSASALPAVEVHISDIKAREEFRHHSMTAGACRVMISGKGFNGYAEALDQIAQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHK9</accession>
    <name>A0A139SHK9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit gamma/tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08030"/>
    <dbReference type="EnsemblBacteria" id="KXU34037">
        <property type="protein sequence ID" value="KXU34037"/>
        <property type="gene ID" value="AXK12_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="340" mass="37375" checksum="692360A28FEFD876" modified="2016-05-11" version="1">MQNKTARTTATHVPLAWPEALQGTPSIAVLENAIAKNRLAHGLLLHGDDFTLLTQVALALADRLLNTPEASAYFPVAQHPDCFALRPSGASRQVSADDTRELIGKTQVSGSVSPRKVAILYECDRMNLAAANIFLKTLEEPPANTTLLLLTTQPYALLPTVRSRVLHFRFPVGSDSLAQAAGLPAWLSDYQAWLGQLCEGVTGKREIADSIFTLYGLVARFDAILTTATAEAWESEKNALSEELDKEEQKAVEKRLANGIRQRIFAEIEQATRAFALPRLTRADSREGENAAETTARIRRAHTAAISELEHSVGLLRLNLNHAAALENFLLHSMRLWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM1</accession>
    <name>A0A139SHM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_08380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713340.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08380"/>
    <dbReference type="EnsemblBacteria" id="KXU34033">
        <property type="protein sequence ID" value="KXU34033"/>
        <property type="gene ID" value="AXK12_08380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="308"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="414" mass="45281" checksum="609ABABDB7A2C587" modified="2016-05-11" version="1">MSPNLRIAYRFLTAKKRAMLMSLSCIVLGVGLFVVTQATTKGFEEFFIRTILGTRGAIVIEDQIQDTIRSMSAGGGGSGFELQQKEGRKYIQGIREPKLLIEALAQFPSVLAVSEVVTGNLTIKSSFQDAVVKVYGINLEDHMRVSELGNQIVRGELNEFRASPSGAILGLEMAQRLQLDLGDSFVLETGGQSRRYRVAALYETGVSDIDRVTLYLNLSEARSLLSRPTGASYLQVNLADKDRAPAEADHMREVLGHSAKSWQERERSWLQAFAALSYSSAITVSVFTLIAGLAMFNTLAMLVMEKTKEIAILRSMGYTREDISQIFLWQAGIVLAIGCLLGMGFGAGVTYAVSKIPLSISGIFKTETFVVSWNKWHYVSASATAITMVMIASLIPARRAARLEPGDVIRGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHP2</accession>
    <name>A0A139SHP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713276.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08185"/>
    <dbReference type="EnsemblBacteria" id="KXU34004">
        <property type="protein sequence ID" value="KXU34004"/>
        <property type="gene ID" value="AXK12_08185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299261" evidence="1">
        <location>
            <begin position="23"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="300" mass="32613" checksum="4199FD8A5976D1EF" modified="2016-05-11" version="1">MPRLKTCFFLVVALASALPASAHHLWLYASRYDAPRLATARQWGQWKPDSVILFGYGDYYPLHDLLEPAQVASLTRYSANGDQQPIRLGSGPFLASELAVFSEGAHLVAASLQPRFVARVGDEAQHHYVFVPRDEVMEGLPVIRSFLYHNYAKALFQVGPRERASSPADAALLARPVGHPLEIVLLSNPRELGEAKSKAGQERSLGGGGLDFAVRFNGQPLAEAYVQARHLGLPKSEVGATWTLELDEAGQGTLPAPRAGIWELQVSHRAAPAPELADKVGDLRYSASFTFEVPAASPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHR4</accession>
    <name>A0A139SHR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_08325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713320.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08325"/>
    <dbReference type="EnsemblBacteria" id="KXU34024">
        <property type="protein sequence ID" value="KXU34024"/>
        <property type="gene ID" value="AXK12_08325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="226" mass="24510" checksum="E62CD6046A4E0055" modified="2016-05-11" version="1">MSANNSPQNDRAADPRLEQLAASDESLLHVHDRASAGAPDVGARYQLLPLALLFIFSGLIFYGGTYLNRYSGHFSAEVFDERKLPGGEVQVVQIDPITLGKRQYALACVTCHMPNGQGLPTVYPSLVDSEWVTGSEERLIRIVMHGLKGPVTVKGETFNAAAMPAFGQVPGSGYNWSDERIAAVLTYIRQEWGNDATPIETATVAAVRAEIPARAEWSEAELLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHW4</accession>
    <name>A0A139SHW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large, multifunctional secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713126.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07745"/>
    <dbReference type="EnsemblBacteria" id="KXU34165">
        <property type="protein sequence ID" value="KXU34165"/>
        <property type="gene ID" value="AXK12_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1080" evidence="1">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="26671" checksum="42CBD71DD12FB848" modified="2016-05-11" version="1">MTIKGTLNTGAAIAAASVNAQVDPPPLDNEVWAPEPAHVATPLNAAPSDAIVLFDGSGISEWESVEGGDASWQVEEGGILTVVPGTKDIRTKRSFGDAQLHIEWRTPIYAEKKTGQWPGNSGVFLQQRYEVQVLDSYENKTYVNGQAAAIYKQAIPLVNASRAPGEWQTYDIIWTAPRFSQGGGLISPARITVIHNGVIVQNNVTLSGKTEYRDPPSYSPHGPAPLMLQDHGEQVSFRNIWIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI15</accession>
    <name>A0A139SI15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_07895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07895"/>
    <dbReference type="EnsemblBacteria" id="KXU34187">
        <property type="protein sequence ID" value="KXU34187"/>
        <property type="gene ID" value="AXK12_07895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="465"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="531"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="595" mass="63196" checksum="F694D7EC94CC428D" modified="2016-05-11" version="1">MKAVTDPAKQFMQRLLRLMRWRVWLAEKLHPTEWQVTLLWAALAGLLGALAALFFSACAEGIHQVLTNSTAGVVESMRVLPWWARLLVPATGGFLAGMVLLLGARFLKGQSATDYMEAIVIGDGRLPLRTSLVKIAASLFTIGSGGSVGREGSMVQLAAVLASLVGRWRRFSPQQLRLLVACGAAAGIASAYHAPIGGSFFVAEILLGTIAMESLGALIAAAVAATLTMQVLGSSGAIYEVPRFELHSPLEMGPYLVLGLLAGAVAPFFLKSLRRAESLFVETRLPLVARLTLGGLVVGAIAISVPEVAGNGYTVVVDILNGRIAWVALIGILICKWLATASSVGSGAQGGVFTPTLFMGAAGGYLFGTAVNGLWPQAAIDPSAFALVGMGAFLSAASRAPLMAVILLFEMTLSYNIILPLMLCSVVAYFMARGIDSHSLYGEVLRRKEAESTSHVLESRVVRDLIKVDPPTVSPRAHFAQLAKLFLSVRINNVYVADEVTRRWIGAVSLHDIKPYLSEPTLVDLVLAGDILREDFPTVRPEQSLSEALGKFIGSEVQRLPVVNASGILLGSISKNDLMLAIVEQGKSGERAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI23</accession>
    <name>A0A139SI23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713186.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07955"/>
    <dbReference type="EnsemblBacteria" id="KXU34197">
        <property type="protein sequence ID" value="KXU34197"/>
        <property type="gene ID" value="AXK12_07955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299266" evidence="6">
        <location>
            <begin position="24"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="470"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="755" mass="83580" checksum="5C4D1720A9EE15A8" modified="2016-05-11" version="1">MKPPKLLPIALSLCTFTLGSLHAQQSPEQDDDEIVRLSPFTVQESADMGRYQAAQASSGSRIRMDLMDSTQSISVLTNEFLNDIGTTQLLDAVKYVAGIGNANNPDIMDIINIRGFGSLGATLDGFAQSSLINLDPIIIDRIEVVKGPNAIIAPQGPPGGLVNSVTKRPLFKNSGSVSYQVGRYDANRAEIDANYIIKDDKLALRVVGAFTDADRYTKEKYSQNLTVMPMLTYRISPTTELTAQVMVYNASATMTNIPASFYAVGRSNVHIMEGLSRDFALATRNDNRHESGQRAQFFLTSQLTDKLSMRLAGNWAQSASRASEIHPGRPRDVNGVPIDPEPAQVNLITGEWEWDGVTRLDDPLFIPSGAKDLTDRDSANLQNDFVFEHLGQGWKSQTVAGFAINYSSSGGGYKNAVAVPVNGSNLFDLTDSSFSPVSYMVEPDAEWVAHNSLRNRSHQVYLYQVLNLFDDRLALSGSLSQNRYFSGRTDNLSGTSTEERAEATLASGGIVYKLTSAVSLYYGYSEQEILGLADPNNLIPAHTSPSRQHEGGLRLRLFDGRLYTTFTYFDIKQDGVWEPDAANWIDPTAPKRPGINSNRTAKGFEFEFAWSPTKNISVIGSFTDFKNRDQGNRRYAHVAERMAGIWGSYTFSETGALRGLSFGLGANYVDERPGDSGGQYTTPPQGFPPARYQPLFWLPSYTEVEANATYRFNKHWKAQLVVKNLLDKEFFRSSSNRTLYLSTPFNPKLTVRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI68</accession>
    <name>A0A139SI68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="12" type="ORF">AXK12_07880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713162.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07880"/>
    <dbReference type="EnsemblBacteria" id="KXU34184">
        <property type="protein sequence ID" value="KXU34184"/>
        <property type="gene ID" value="AXK12_07880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="626"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="809"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133785" checksum="452174A27BE81826" modified="2016-05-11" version="1">MSKARAQVVSGVCPPARGLALAELIAAHPEQTLWLVVAPDAKTAEHLAEDIPFFQNLGEARSTKTRASACDREHAPKKKRAAPPRPIIEAATFPEAMPDTRDMRDAFAASSQRLAVLSKLRELRATVAGDSTRRRSAPLDARAGAPLVVLCTLPALLQPVPALEALSSREITLRTGQAQPFAGLLEQLQALDYDCEALCEAPGHYAVRGGIIDLYPITATQPYRVDFFGDEIESIRLLDPVTQRSGSPVESITLSATPRVKLDPARSGLADYLPADHTALVFIEAAELDEVFRRETTSEGEGQADPLETLSTIRAKAALSISLCEIEQESELFPTPPHDAEGPARPSLDKRVCDPLALHRRYPTEALLAHERVAAEADARRDFLEQLVQWQRDGYALHFVASRDGEAQRMTEILEEEGLAKTLRVQTHIGSLNEGFLYRSGADSSPRRLAFVTEVEIFGRQRARRPRATTQQVAQRAQIDQLLDFSELVEGDYVVHLQHGIAHFRGLATLDTAQGPREVISLEFDEQVTLHVPLQESHLISRYVGLTKVRPQLGKIGSGRWEKTRKAAERATIDLAAELLRIHAAREAQPGFACPADTDWQKEFEASFPYTETRDQLRAIEDTKADMERTRPMDRLICGDVGFGKTEVAIRAAFKAVQGGRQVALLVPTTVLAQQHLNTFRERMAGYPIVVEMLSRFRSRKDQQAILAATAAGQVDILIGTHRLLQSDVAFKSLGLLIVDEEQRFGVKHKERFKALRATLDVLSMSATPIPRTLYMALTGARDLSVIETPPADRHPIHTIVKTYDEKLVAEAIHQELRRGGQVFYLHNRVQTIDLIAARLRELVPGARVGVGHGQMEPTELERVMTDFVAGTYQVLVCTTIIESGLDIPNCNTIIIESADRFGLSQLYQLRGRVGRFKHQAYAYLLLHRHSRLLDIARQRLGAMRQHNQLGAGFRIAMRDLELRGAGNLLGSQQSGHIVGVGFELYCQLLRQSVARLKGEAQAAAIRATVKLDFVVVGDDRETAETKAGDDLRPTRRTQNKGQFVSGYTALRDAEHAAAPPLAPIRACLPANYIPETRLRIDFYRRLALAGSSAQLKEIAAELRDRFGKFGEPVNALLTLTEIRIRAEQKGILSVETEGAKLKCLRAKPLNTPSAPPGRASNGSPPNNPAKQPWVQHGTRFPRLTAPKPLLRLREILIFLNNLPDSPPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI78</accession>
    <name>A0A139SI78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07940"/>
    <dbReference type="EnsemblBacteria" id="KXU34194">
        <property type="protein sequence ID" value="KXU34194"/>
        <property type="gene ID" value="AXK12_07940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="252" mass="28323" checksum="7D29E7C5BA991E49" modified="2016-05-11" version="1">MAFCWLIIYTGVGGIHAIISLILNFYDIRGINRYSEAIAALGLLYFAFSIHRGMRNWPFRAKLFSLALLAPLAILDQSFKMYTFPFNINSSIKERVTADRGLASTLESRVEAGSMIYTLPAMDFPEPFLGRGASRFGSSFYNSMRPFLYSSKLRYSYGSDKGRQGADWQLDVQELPAGEMAALLESYGFSGILLNRKGYEDHGNHLLEELAKAGWPAEFEQGLDNEWVFIRLTPTPNPTLPTLTPYALASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI93</accession>
    <name>A0A139SI93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712981.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07370"/>
    <dbReference type="EnsemblBacteria" id="KXU34292">
        <property type="protein sequence ID" value="KXU34292"/>
        <property type="gene ID" value="AXK12_07370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="31016" checksum="4AFFBA508C75182B" modified="2016-05-11" version="1">MTVTQVKRIVEITVYTMLVVFAVITLIPFAHMLAGALKTKFDYAATLFLPAGDGFLGIGWDRITVDNFVRLFTELKISRAMLNSLFLSSVTSSLTVLFCSMGGYALSKLQFKGREAVTMVVLVALIIPGPLLLAPGFKLLYQLGLLNTYTGLILPGLTPAFGVFLFRQAMLNGIPSELLEAARIDGANEARIFFSLVLPLVRPMMGAYLMISFMGTWNNFISPQIILQSPDLQPLSVALNSLKGIYGTDYGLIMAGTIVSIAPVMCIFLLLQREFIAGLTGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF0</accession>
    <name>A0A139SIF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713032.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07520"/>
    <dbReference type="EnsemblBacteria" id="KXU34316">
        <property type="protein sequence ID" value="KXU34316"/>
        <property type="gene ID" value="AXK12_07520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="402" mass="43743" checksum="F994004A14151652" modified="2016-05-11" version="1">MALPFFTKPKHTKPLLNRCRDDLATKMRLKYDPYYHVIQAQQGSRIQLGGRDMIMLASNDYLGLSFHPKVVEAGQTALRKWGASPTGARSANGSRAYHIELEEKLAAFLGREACHVHSSGYLSCVAATASFAQKGDLIFGDKNLHSSLWDGIRLSMATVERFAHNNPDDLREALEASSPAATKMLVLEGVYSMEGHICRLPELAQLGEAHRCFTVLDDAHGLGVLGEGGRGTAAHFGLGDQVDILCGSLSKSLGSTGGFVAASREVIEYLRTNSKQTIFSAALSPAQTAIASAALDVLQNEPEHRERLWANTRRYRDMLHSLGLDTWGSETPAIPIVLGSKERAYPFWQALREKGIFTIMSIAPAVPAGKDLIRTAISALHSDEQLDQIGEAMAYAVKKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIJ0</accession>
    <name>A0A139SIJ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_07705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07705"/>
    <dbReference type="EnsemblBacteria" id="KXU34356">
        <property type="protein sequence ID" value="KXU34356"/>
        <property type="gene ID" value="AXK12_07705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="462"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="571" mass="60666" checksum="F4171889C590F921" modified="2016-05-11" version="1">MRRKFRPRLFTLPRSTYSQGQLVTDSLAGVTVALIALPLALALAVASIPAGIATPLPVPAIGIFTAIIGGFLVSFFGGSRVQISGPTAAFVTVILLIIDKHGYDGLLLATIMAGAMLVLMGLSGLGTLIKFIPYPVTSGFTTGIAIAIIVGQVPGFIGLPAEATPPREFFEKLPWLFAHLPGLNWRTLLVAAISATLIFLWPRYAARFRAERLPAPIVAIVVAAGLVVLLNWQESAGVATIGSLFGPDALPRELPPLTWPEISLSRIGELMGPAITIALLGAIESLLSAVVADGLANDRHDSNTELVAQGLANLVCPFFGGIPVTGAIARTSANVKAGARTPIAGLVHALTLLLIVLFLAPFAQYVPIGAIAAVLIFVALRMGNWRELARLRKMPRSDALVLLTTCSLTVVFDLVVAVEVGILLAGVLFIKRMAETTEISRVTAHDELETPEQVAHGKPIPEGVVVYRIFGPFFFGAAEKMETALLSSGAPPPRILILRMQLVPAMDATALNALESIVERMQASGGQVVLSGPHRQPLEMMRRAGFLEKLGRANIRPHFDAALTRANELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIK9</accession>
    <name>A0A139SIK9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00415"/>
    <dbReference type="EnsemblBacteria" id="KXU34412">
        <property type="protein sequence ID" value="KXU34412"/>
        <property type="gene ID" value="AXK12_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="18571" checksum="6F1CABC54BAEFBA2" modified="2016-05-11" version="1">MLPVGAIIVGVIGLLLGGYAALTIGNVKRTLAEHEGKMARFDQFESQVSTAASASEKATRDIGALTRSTQDAFNQVGAELGNLRGAITKLEEAPRTRAAATAAPAANRGNAAAAASANAGTTASNNAAARPAGAASGEYVVKSGDTGVKIAREVGISLGALQNANPDVNWNRLHVGQKLNIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIL6</accession>
    <name>A0A139SIL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713039.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07540"/>
    <dbReference type="EnsemblBacteria" id="KXU34320">
        <property type="protein sequence ID" value="KXU34320"/>
        <property type="gene ID" value="AXK12_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="284" mass="30866" checksum="1A71CA3C5594BFEC" modified="2016-05-11" version="1">MSPNWRKALYLFGGSLGVLGIVFVALRLHSYVEELDFSQFTPRVWSLIFFLSVVYGAANLFLAVAWRKLLLYFDSQISVAQAIRLFGLSQLAKYVPGNIVHLAGRQALGMAIGLLPKPLAKSVLWELGGLLVAGALFTPIVAPLVFELVSAWLSLTVFTAALLCAWFVVRRLFTTTVSNALLDQCSFLAISGVIFVILLELVSPQSYSVSLFPALCGAYVIAWLAGFVIPGAPAGVGVREFVLLFLLKDLVSEADLLLAVVLGRAITVLGDLIFFLTTLVIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM7</accession>
    <name>A0A139SIM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_07600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713059.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07600"/>
    <dbReference type="EnsemblBacteria" id="KXU34330">
        <property type="protein sequence ID" value="KXU34330"/>
        <property type="gene ID" value="AXK12_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="435" mass="45944" checksum="81998D1F1E0138A0" modified="2016-05-11" version="1">MRLLTTSSEDFDRELAAFCREAAVPAQITESVAAILADVRERADVAVAHYAEKFDGARLAPSEFRVSPEGLAAAYARLPVAERSAIESAHAAILAYNREGLAQPWQHKNPHGATVGEKFDPIRRVGLYVPGGQVPLVSTVLMTATLAKIAGCPEIAVFTPSDAQGRVADGLLAALHFLGISEVYRIGGVQAIGAMAYGTETIRRVDKLFGPGNAYVCEAKRQVFGTVGVDSLPGPSELMVVADKTARADFVASDLLAQAEHGSGREKVYLVVTSESLASAIESEIAAQARTLSRSEKAQRVLDVGFLIIVVAGLDEAAAIANTVAPEHLELIVEPDAEAALLKKITTAGAIMIGNHTPTALGDFTAGPSHVLPTGGSGRFFSGLRVADFVRRTSLVRYDRESVAKAEPVVAAFAAMEQLDAHGRSVSIRVAPQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN0</accession>
    <name>A0A139SIN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glcE</name>
        <name evidence="2" type="ORF">AXK12_00575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712942.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00575"/>
    <dbReference type="EnsemblBacteria" id="KXU34438">
        <property type="protein sequence ID" value="KXU34438"/>
        <property type="gene ID" value="AXK12_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="353" mass="38086" checksum="DAABD5E52AFF966F" modified="2016-05-11" version="1">MRSSDANHSQALIEQVKQALANRTPVRIRGGNSKAFLGRAVDGLEIDTRPHRGIVNYDPTELLITARAGTPLSELEAALDAAGQMLPFEPPLADQGATVGGMIATGLSGPRRPWVGAVRDFVLGTRVINGDGHHLRFGGEVMKNVAGYDLSRLFTASFGCLGLLTEVSIKVLPKPRHTATLALSLTPEAALTQLAEWGQRALPISAAAHDGNTLYLRLEGGEGSLKDARNRLGGDGVDSDYWSQLNARTLPFFTDPLPLWRISLPHNTPLFALPGAQFLDWGGAQRWLKSDAPADAIRAIVRTYDGSATCYTQGITDSPFAPLSAILMRYHCQLKAKLDPLGIFNPGRMYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN1</accession>
    <name>A0A139SIN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">AXK12_07590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713107.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07590"/>
    <dbReference type="EnsemblBacteria" id="KXU34354">
        <property type="protein sequence ID" value="KXU34354"/>
        <property type="gene ID" value="AXK12_07590"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="195"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="222"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="513" mass="56978" checksum="DAC8BF375A94182C" modified="2016-05-11" version="1">MPQTIAVLDFGSQYTQIIARRIRECEAYSRLYPYGTSAEQLRADGVIGIILSGGPSSVFAKNAPLPDPKIFELGVPVLGICYGVQLMGRLLGGAVAKSKEREYGHGTLSIAKPGRLFNKLPRKLRVWNSHGDKLTALPPGFAAIGTTENSPYAVIEDRARNFYGIQFHPEVFHSERGSDVLRNFLLNVCGATQDWTTKDFIKHAVSDIRRTVGKSRVLLGLSGGVDSSVAAALLHRAIGKQLTCVFVDNGLLRAGEREAVEALYGRHFKIDLRVVDASALFLRRLKGVSEPEQKRKIIGRTFVEVFEKSLKQIGKGVDYLAQGTLYPDVIESVAIDNNPAALIKSHHNVGGLPERMKLKLLEPLRELFKDEVRAVGEALGLPREVVWRHPFPGPGLGVRVLGEVTRDKLEVLRQADTILLEEMRKSGWYAKVWQAFCVFLPVKSVGVIGDERNYSWVIAVRVVESIDAMTADWTRLPYDLLQHISNRITNEVRDVSRVVLDISSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIW0</accession>
    <name>A0A139SIW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protease Do</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07130"/>
    <dbReference type="EnsemblBacteria" id="KXU34518">
        <property type="protein sequence ID" value="KXU34518"/>
        <property type="gene ID" value="AXK12_07130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="305"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="505" mass="53396" checksum="0CDA3A333CA25EDF" modified="2016-05-11" version="1">MSRAASARSFALSIFCKICQPEVFWMRTKFAALLFAGLVGWGLALLFTRGIGDGDTLLPRPAEPQRTTTILQIDPTPLAHAADEVRVSYADMVEAVQPAVVSVYSTKIVSTRMGADPWARIFGGPSAPRQQREEGLGSGVIVSRDGYIITNNHVVEGADELSVLMPDDREYRATLIGADPKTDVAVIKIDATELPTVTLADSDKLRVGDVVFAFGNPLGVGQTVTMGIVSAKGRNSLGLLENVAGYEDFIQTDAAINMGNSGGALVDAKGRLVGINSAIVSTTKGNIGIGFAIPINLAASIMHSLVETGTVASGYLGASAETVSADVLERLQLPSGAVRGVVITQVTEGGPAETAGLRAADVVYAIGGRSISTMEDFRLQIAQTMPGSAVEIAFVRDGEAMTATVTLGQVVERPNALLEGVDVDLLGPDMRRRLGIDPRVSGLVITNVEDDSPYAGYLIPDVVIVEINRMPVTSLANAQGLLREGRNLLLVTYRGQYHYLSLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIW7</accession>
    <name>A0A139SIW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712792.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07115"/>
    <dbReference type="EnsemblBacteria" id="KXU34515">
        <property type="protein sequence ID" value="KXU34515"/>
        <property type="gene ID" value="AXK12_07115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299252" evidence="5">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="23643" checksum="30511DB740C1AA5E" modified="2016-05-11" version="1">MLKSLKLLGALAALFVSGAAVSQAQVAAPKIVVVDMMKLLDEHYKTEEQKNKLQADAEKASEEADRLLGERNALVEEYKEALEQSNNPATRAEVKDQAREQAEIKLQEIQRKNNELQSFEANTRNLLQQRFQNFKTIMLEEISKIAVEVGKRKGATLVLDKSGPNLLGIATVVYHDESLDITAEVEAEINRDRPAGSSTAGTSGDATPSVSVPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ55</accession>
    <name>A0A139SJ55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">AXK12_07235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712875.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07235"/>
    <dbReference type="EnsemblBacteria" id="KXU34551">
        <property type="protein sequence ID" value="KXU34551"/>
        <property type="gene ID" value="AXK12_07235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="150" mass="16577" checksum="D2BDCEC15DCA3421" modified="2016-05-11" version="1">MSATLAPHYTGLFRHALDDKNRLTIPSAWRFAHGTDDVFLATPHPEGYIAVLPPAEVQKLYDKIAGMALSDGLGQDFVARFFAQTQSLWFDKSGRISLGAGLLEHAGIAKDAVLVGSLTKFNIYTPERWERVEARTSGENFGDIMRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ75</accession>
    <name>A0A139SJ75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ORF">AXK12_07195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712823.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07195"/>
    <dbReference type="EnsemblBacteria" id="KXU34530">
        <property type="protein sequence ID" value="KXU34530"/>
        <property type="gene ID" value="AXK12_07195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="366" mass="39823" checksum="17A8539943ED6A45" modified="2016-05-11" version="1">MKAGIVGLPNVGKSTLFNALTRSRKAEAANYPFCTIDPNVGVVTVPDERAYVLQKIAKTQVVIPAAIEFVDIAGLVAGASKGEGLGNQFLANIREVDAIVQVVRCFEDSDVIHTMGSVDPVRDIEIIATELMLADLDSVTKRIEKTQKKAKSGDKDAQAELALLQKLEPHLADGKPANVLELADDEKVRLKQFHLLTAKPVLFACNVAESDLANAEANPFVQKVADYVRTHHDAAYVPISAKIEYELIDLSPEEAREFLADLGVSDSGVSSLIRASYALLGLQTYFTAGEKEVRAWTIQKGWKAPQAAGVIHTDFEKGFIKAEVVSYDDLTSLGSVAAARDAGKYRLEGKDYIFQDGDVALFRFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJG2</accession>
    <name>A0A139SJG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_07025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712760.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07025"/>
    <dbReference type="EnsemblBacteria" id="KXU34687">
        <property type="protein sequence ID" value="KXU34687"/>
        <property type="gene ID" value="AXK12_07025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="190"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="426" mass="46376" checksum="09D9B4B3CC69BDF5" modified="2016-05-11" version="1">MSKVIISSLYDSPEFRMACRQFDQAADAISLPESIRDRTKHPRRCIAVSLPIRRDDGSVTLYEGYRVQHSLSTGPSKGGIRFAPDLCLGEVAALAMWMSWKCALVGLPYGGAKGGVSVAPAQLSRSELERLSRRYMQELIPFIGPDIDVPAPDIGTNEQIMGWMMDTYSNHIGHLIPSIVTGKPLSLGGSQGRREATGAGVAHLVCRYLTDVLKTPPEHATIAIQGFGNVGSEAALALVQNCGAKVIALSDERGGILNPRGIDVARALAYHRYQGTLAGFEGAEPISNDALLTLPCTVLIPAAVQRVITPEIAAKLRCRLLAEAANGPTTYSADKVLEQRDDIEVIPDLLCNAGGVIVSYFEWLQNRANEYWDRDTVLTKLFAQLDRAKDAVEAQKRKFKFSRRLAAQTLGIERVAHAKQARGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJH3</accession>
    <name>A0A139SJH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712780.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07085"/>
    <dbReference type="EnsemblBacteria" id="KXU34697">
        <property type="protein sequence ID" value="KXU34697"/>
        <property type="gene ID" value="AXK12_07085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="160" mass="17255" checksum="3BCA8B662D69F6EA" modified="2016-05-11" version="1">MANFNKVYLIGNLTRDPELRVTPKGTAICQFGLAVNRSFKDESGSMREETTFVDVEAWGRQGETISKYCQRGRPLFVEGRLKLDQWEDKASGQKRSRLKVVLEGFQFLGGRGDAAEGGAGGGASYGGESGYQRSAPPPRAAAAPAPSSHEPDGVDDDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJK5</accession>
    <name>A0A139SJK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34758">
        <property type="protein sequence ID" value="KXU34758"/>
        <property type="gene ID" value="AXK12_06935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="91" mass="10227" checksum="5618B2D632BF5110" modified="2016-05-11" version="1">MILFWSSILAEFQIIVVPIFLPLLILSMILIGLVFIIKIGEGVELSLEIGMVMVAGIGLLWIKIESGIHRRFLSRARMARSYRDLGLGPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJS5</accession>
    <name>A0A139SJS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">AXK12_06820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712686.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06820"/>
    <dbReference type="EnsemblBacteria" id="KXU34796">
        <property type="protein sequence ID" value="KXU34796"/>
        <property type="gene ID" value="AXK12_06820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="88" mass="9512" checksum="EA84B0D1632DC716" modified="2016-05-11" version="1">MASPFHIKRGDQVVVIAGSHKGKEGKVLEVLPAKSRARVEGVAMIKRHLKKSQDHPNGTIAEREGSIHVSNLMLKATYDASKRGKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJU9</accession>
    <name>A0A139SJU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712499.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34852">
        <property type="protein sequence ID" value="KXU34852"/>
        <property type="gene ID" value="AXK12_06315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299302" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="90" mass="9913" checksum="B66FF3DE6ADF182C" modified="2016-05-11" version="1">MPFPKSRLLFASVLLATAAAAALSSGCFSSAKKKRAEEKSIPLAVEQALKDRWTEKRSTELVQQGLSPYAAQRQAESEFSKKYSYTQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV4</accession>
    <name>A0A139SJV4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712740.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06980"/>
    <dbReference type="EnsemblBacteria" id="KXU34764">
        <property type="protein sequence ID" value="KXU34764"/>
        <property type="gene ID" value="AXK12_06980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="348"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="604" mass="66014" checksum="9BB8BD14CB9FF0DF" modified="2016-05-11" version="1">MPRPLLSVRDLRTYFHTRSGIYRAVDGVSFDLARGETLGIVGESGSGKSVTCYSLMGLVPQPPGRIESGSAIFDGLDLLQCSEAQARAIRGKRISMIFQDPMTSLNPYMRIGAQLMEPLLIHEKISKTAARARALEMLHAVGITEAQARLRAYPHEFSGGMRQRVMIAMALITRPDLLIADEPTTALDVTVQAQILELIGKQQRELGMAVIFVTHDLAVVSRLCDRTQVMYAGRIVETAPTRELFANPQHPYTRALQRCIPALQPKGRPLYSIPGLPPDLSKPLSEAQLLARFEDLPETERVDARRDDGSAAASGVASAASTDSPEPPRIIGDRPAIEVRDLHTHFALKTGGLFSRQQTVVKAVDGVSLTIREGEVLGLVGESGCGKSTLSRTLMELVPATAGSVILEGRTLNARSMSRANARAAKGSDTRRAMQMIFQDPYASLNPRMSVYDALAEPLLVHRICAPAEIPARVAQLMETVGLASRFLHKYPHEFSGGQRQRIAIARALALEPRILIADEPVSALDVSIQAQILNLLSQLVRELRLTLLFIAHDLSVVKHISDRIAVMYHGKIVELGDATQIIDHPQHPYTRRLISAIPSIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK07</accession>
    <name>A0A139SK07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ORF">AXK12_06610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712588.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06610"/>
    <dbReference type="EnsemblBacteria" id="KXU34899">
        <property type="protein sequence ID" value="KXU34899"/>
        <property type="gene ID" value="AXK12_06610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="292"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="379" mass="40294" checksum="2A39076F686B309A" modified="2016-05-11" version="1">MSLKRTPLRDFHAEHGARLVDFAGWEMPVQYRSILEEHKAVRRAAGLFDVSHMGEVDVQGPGARAFLDSLVTNDVAKLSAGRVLYTPMCYENGTVIDDLLIYMRGAEDFFLCINAGNTPKDLAWLGDQAARFNAETGAGSVRITDRSAETALLALQGPAAAAILQPLTDVPLAALKYYHFTTGQVAGIDCVISRTGYTGEDGFELYHASESAPALAAALLEAGRPHELELAGLGARDSLRLEAGYPLYGHEISDQVSPLAGGLGWTVKLDKAAAFIGRDALRAEKANGSAQRLVFFKTGDRRIVRAESPVFSGEAGGAAVGRVVSGTLSPILGEAIGSALVDSAATDSAAQLWVDIRGTRLDLQLVKAPFVPLKKSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK55</accession>
    <name>A0A139SK55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="8" type="ORF">AXK12_06645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712603.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06645"/>
    <dbReference type="EnsemblBacteria" id="KXU34906">
        <property type="protein sequence ID" value="KXU34906"/>
        <property type="gene ID" value="AXK12_06645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="6">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="7">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="264" mass="28495" checksum="7BEDAB8C1D51D833" modified="2016-05-11" version="1">MSETAPSPVPTATARNANRRHDGRANDQLRPIQFELGIAPHATGSVLVSFGQTRVICAAMIEPKVPAWMRQQGIKGGWLTAEYSMLPYSTLDRKSRDSSRGKQDGRSVEIQRLIGRSLRASIDLDKLGENTLWIDCDVLQADGGTRTASITGAYVAARLAVQKLIDAKRIAENPFRDSVAAVSVGIVKGVPVLDLDYIEDRDAEVDANVVMTGSGQFVEVQGAGEEATFSHEQLQQLLALATGGLKTLAAQQQTQIARALLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK58</accession>
    <name>A0A139SK58_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_06425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase HII family. RnhC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712536.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06425"/>
    <dbReference type="EnsemblBacteria" id="KXU34870">
        <property type="protein sequence ID" value="KXU34870"/>
        <property type="gene ID" value="AXK12_06425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004641">
        <property type="entry name" value="RNase_HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00716">
        <property type="entry name" value="rnhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="11">
        <location>
            <begin position="113"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="347" mass="37813" checksum="304334BD3328CC61" modified="2016-05-11" version="1">MAKRAVSRGASDAPTAPKTLTSYTIKLDAAQQAKLRAHCEGRGWERAEVAYTHFAFKSEQARLNVAAYTSGKVVIAGKGTEDFVKNVIEPEITGSAELGYEAERHPEWFEPHAGLDESGKGDFFGPVIAATVIADRAAIEAWREAGAQDSKKMTDGRIVALDKLIRATRGAVVRTCFCKTMARYNTLMSRPRANLNSLLAWQHATALSEALVAKPVAWGLLDQFSEQPLVQRELKKTHAATLPAGFELKMRTKAEEDPVVAAASIVARAEYVRQMHTLSERFGEPLQKGAGPLVKKQAAHLIDKLGAAALGDFAKLHFRTAYEVVSAAGKLDELPLRPPPPKMSQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK72</accession>
    <name>A0A139SK72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06385"/>
    <dbReference type="EnsemblBacteria" id="KXU34926">
        <property type="protein sequence ID" value="KXU34926"/>
        <property type="gene ID" value="AXK12_06385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299280" evidence="4">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="66"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="400" mass="41682" checksum="43609AFCDAE1E54B" modified="2016-05-11" version="1">MTKSKPFAALALSTVALSLALAGCGKNGGGAQGGPGGWPTPEANILTIETQPVTLSRELPGRTSAYRIAEVRARITGIVLKRHFTEGADVNAGQLLFEIDPEPYQATLDSARANLARAEASLLSAQAQARRYEDLVGTDAISRQAYDNADADAKARAAEVAAAKAAVRTAEINLGYTRVVAPITGRIGRAEVTEGAYVQQGQATLLATIQQLNPLYVDLSQPAEDALQLKAAVANGSLQKNGASAALTILFNNGESYAERGALEFSDVTVNPTTGTVTLRGTVPNPALDLLPGMFVRARVEEGTKPDAILVPQSVVTRDQRGQATVLVVESGERGDVVGVRVIEATRTVGSDWLVTGGLAPGDRVILDNRQKLRPGAPVKPLLATAPASTAPVAAPESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK91</accession>
    <name>A0A139SK91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="12" type="ORF">AXK12_06300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712488.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06300"/>
    <dbReference type="EnsemblBacteria" id="KXU34973">
        <property type="protein sequence ID" value="KXU34973"/>
        <property type="gene ID" value="AXK12_06300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="364" mass="38749" checksum="257C59B6B135EA19" modified="2016-05-11" version="1">MSKALPGRSIGSSNVSREKNIELAVSSITKQFGEGSIMRLGSNQKMAVDCLSTGSLLIDLALGGGGLPKGRIIEIYGPESSGKTTFCLSVIAQAQKLGGLAAFIDVEHALDPKYARTVGVKLDDLLVSQPDSGEDALNIMETLIRSNSIDVIVLDSVAALTTKAELEGQMGDATVGAQARLMSQAMRRLTAVVNKTKCICIFTNQIREKIGVMYGSPETTSGGRALKFFASVRIDIRRREPLKGAEGTIVGNRTKIKVVKNKIAPPFTEVEFDIMYDEGISSSGSLLDLGLHHKVLEKRGSWIAFNGELIGQGRDATRLTLKEKPELAEKIQAAVMAKVDALKGGEDAALPDPSTENSDTDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE2</accession>
    <name>A0A139SKE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712394.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00280"/>
    <dbReference type="EnsemblBacteria" id="KXU35039">
        <property type="protein sequence ID" value="KXU35039"/>
        <property type="gene ID" value="AXK12_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="644" mass="71412" checksum="3022ECA60D793B46" modified="2016-05-11" version="1">MCGIAGFISAKAGEEELERAVAQMCAAMQHRGPDDEGQFVGQGAALGMRRLAIFDPAHGKQPMASADGRYWLVLNGAIVNHPELRSELARLGHVFRSECDTEVLLAAYVQWGAACLPRLRGMFAFAVWDTRAQVLFAARDALGIKPLYYTRRPGGGLLFASELRALVASGQVSRELDPAALGEYLAWSTVPAPRTIYNGCAALLPGHRLSCDRLGRVRTEPWWQFPELDPRDAQRGSGKDLVDTAAHETFRRHLRSRLEEVARLYARSDVPLGAFLSGGLDSSACVALLRHTGAQQLKTFSIVFDEAGYSEENSAKVTAEALGTEHHELRLTGARVAADLPRILGCFDQPGGDGVNTYYASLAAKEGGVTVAVSGLGGDELFGGYPSFKDVPKLARWLPRWRMLPVRLRQLIVARLRGRADMRSRLLGDWLGTGRDIHELAAMRRRSFAETQRLALLAPEARRHAERLGPLHPLIDSLPLELGSADDFQIISAWELRSYMSDILLRDSDSFSMAHSLELRVPLIDSGLVEWLWAQPTALKYDPRVTKWGLAEATRDLLPRAILERKKQGFSLPFPLWMRGPLRPFLEECFSLKTLGECPWLTASVARAMWEHFINGNDSRAWSRLWSLAMLIAFCQRRVAGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKI1</accession>
    <name>A0A139SKI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00320"/>
    <dbReference type="EnsemblBacteria" id="KXU35046">
        <property type="protein sequence ID" value="KXU35046"/>
        <property type="gene ID" value="AXK12_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="248" mass="27026" checksum="806FDBFCFBA1FE73" modified="2016-05-11" version="1">MRFIYSRCAAFLPVGQANAAYFRHCSVPQKKLFPAPHCVNVEHFTPTPDHLENASELRSSLSIPADATVLLFAGKFIPQKRPDLLLSAFLPIALEFPSAHLVFSGDGALLPKLRETLSTAEKLIRQRVHFLPFANQSAMPARYLLGDCLILPSESETWGLAVNEAMHLGRPAIVSDRVGCHPDLIQHGKTGWVFHSGAKEALTETLRNVLSLSRAELAEKGRAAQAHAASFNYDNATAGLLAALKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX9</accession>
    <name>A0A139SKX9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712177.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05785"/>
    <dbReference type="EnsemblBacteria" id="KXU35212">
        <property type="protein sequence ID" value="KXU35212"/>
        <property type="gene ID" value="AXK12_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="160" mass="18304" checksum="8470A2E4E5FAE857" modified="2016-05-11" version="1">MNYTTYDIVFREIPGEVTLAINLSNCPFRCEGCHSPELQEDSGEPLTVERLVELIAQNPGITCVCFMGGDRSLDELKKLSRAVFAHELKRAWYSGRSELPQEIFAYFEYIKVGPYIKERGPLDSETTNQRLYQIIPQDTGCYLAKDITALLQKNNFRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ8</accession>
    <name>A0A139SKZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">AXK12_05800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712182.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05800"/>
    <dbReference type="EnsemblBacteria" id="KXU35215">
        <property type="protein sequence ID" value="KXU35215"/>
        <property type="gene ID" value="AXK12_05800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="280" mass="30734" checksum="261E0A5D56A3E376" modified="2016-05-11" version="1">MQIVESISDMQALARTWRAEGRRVALVPTMGSLHAGQAALIRAACSAADVVVVATFLNSLQFSPNEIVEHYPSDPAGDRQLCEEAGATVMFAPRAAEIYPSDYSTYVSEERIAAPLCGVSRPAHFRGVATLTTKLLNIVQPQVIYFGQKTVQRAAVVRKLIRDLGYSIEVAVVPTEREPDGLAYGLVNREFTTSLRAQALAVYRALTKAREMVAAGVRSPDRLIAEATHILGEERRLRVIYIAIVDPETMEAVREVLPGKSLLAISVWVDEHRLLDNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL11</accession>
    <name>A0A139SL11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712249.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05960"/>
    <dbReference type="EnsemblBacteria" id="KXU35242">
        <property type="protein sequence ID" value="KXU35242"/>
        <property type="gene ID" value="AXK12_05960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="650" mass="72268" checksum="C7DB9677F8C6CC30" modified="2016-05-11" version="1">MPSKTGKTLDFAALPDKRWPGRLVVGGQTLDDFVAVAEEPSPDASWTVRVFQSTSVPTLQIREQWRTIGAVTEWIPTLVNNSAELSGKITGVRSLAASWQTRGPVDFYGNKGSEAELDDFEDRTELDIDTITLMPKGGRSSDGIFPFFALTDRNDALAIGIGWSGRWDATLRHASGNLEVDVGLPQVGFVLRPGESVRLPSILLAQASGASAEQIRRVVRAHLANHVVPKHPAGKIHNFIAHGMMHQYHVTKDVSEQIELEALERAAALGFEAHWVDACWYGDTPDWSGEVGSWNVRRSDFPRGLRPLSDRAHELGMKFIFWMEPERAKPHTEWPRAHPDLFLSFPGDPSEHVGNFWKENVLLLNLGDPRAVDLAFEKISALITEFNADIYRQDFNTTPLDAWYAADAPDRVGMTEIRYVEGLYALWDRIQATHPGIVIDNCASGGRRIDLETLRRAVVLTRTDAVDVGCRATQEGKIDIVNQVECWGLGHWLADHAVLNHTFDAYGVRGALCTGFMAYRVLPKDEHDPEYADAIAAVAEMKRLRSFMADERIGLIAPDLEKEAWMAYQHHRHSNSSGIIVALRGPGADTDSVTLHPEYIDANATYQVTKWNDYRADPLVQLSGAALKELAITIAQTRSSVLVEYQRVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL75</accession>
    <name>A0A139SL75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712100.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05570"/>
    <dbReference type="EnsemblBacteria" id="KXU35316">
        <property type="protein sequence ID" value="KXU35316"/>
        <property type="gene ID" value="AXK12_05570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="423" mass="46886" checksum="50DF21E09868DA0A" modified="2016-05-11" version="1">MVESWLTGIQGWLLTRGLSAEYAELSQLAFSLALLLVLAWVANLVAKRLILRGVAAAVRRSPMKWDDALLEAHFFSRLSHLAPAMVINALGGKILGQSPEVLAVVNAAVSIYLTLIWVIVFFALLDALHLLAQRSGRAERTPVKGFVQALKLVAAVFALILVLATILDKSPVYILTGMGALTAVLLLVFKDAILGFVAGIMISVNEMVRIGDWIEMPKAGADGDVIDVSLTTVKVQNWDKTITTIPSYDLISGSFKNWRGMFESGGRRIKRALYIDMHSVRFADEAMIEQWRRIDLLTAYLDEKQAEIDQDNQQRGTDLTILGNGRRITNFGTFRAYCVAYLRQHPRINQGMTMLVRQLSPGEHGIPLELYVFTNDTRWAMYEAIQADIFDHLLAVIDQFGLSVFQTPSGGDLNAAVAQLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL87</accession>
    <name>A0A139SL87_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712056.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05465"/>
    <dbReference type="EnsemblBacteria" id="KXU35297">
        <property type="protein sequence ID" value="KXU35297"/>
        <property type="gene ID" value="AXK12_05465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="661" mass="71190" checksum="A001A30EF6743557" modified="2016-05-11" version="1">MQFYAPQLLWLILIPAALLLWELGRRARAAARAHPKILSAEARANTVRLTALAAREPTRARPIKRGGRPLLWIGLALGIVALARPQYGEREVSVFEQSREVLIALDLSRSMLAEDVKPSRLARAKLLITGLFERLAGERVGLIVFSGTAFLQSPLSSDYEILREFLPSLGPDTLPEGGTNYRALLDTALDAFSDSPATDRFLIILSDGEATDDTWAHTLDALKKRGIRTIALGIGSPAGAMIPDGGGGAGEAGGFVKDERGAVVLSRLEPATLRALATETRGLYRDASTWLDLAALITETVEQGAQGQFTDTRTQRLIDRYQWALAPALGLLLLSFLLEFPVRPRPRSLTLQPAKNAASLLLLAALILGNTAIDARAQSVGDLREQLAHDENAAAAPSSALGKIVTRLADSPTPPTGRNWAELARETITWGQKLQTEQHPVPPGPVHDALHAVTLGEALDPKTADWPQLRSELEALLQTQEQQDPEKPEDQSQQNPEQNKTGDSQNSQGGDQEQNQDGSQDGENRKSNSDNSESQNSGDPQTDDSEQSGQNDGQQSQGPQSESLGDMSEDAPKPEAENEARDRNEDAQQNGAATAPPHKGPTQQVGGAQAQSPTTEAKDPALAAALQKLEQIKGSDSPAQLFQLMDNTPRDESANASKKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLB1</accession>
    <name>A0A139SLB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ner transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712314.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05615"/>
    <dbReference type="EnsemblBacteria" id="KXU35274">
        <property type="protein sequence ID" value="KXU35274"/>
        <property type="gene ID" value="AXK12_05615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038722">
        <property type="entry name" value="Ner_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13693">
        <property type="entry name" value="HTH_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="83" mass="9134" checksum="847C87660F5C732C" modified="2016-05-11" version="1">MHPEQIKALLRMKGITPTALADELGVGHSSVSQVISGKSVSARIRASIAEIIGMSVEELWPHPRPALRRTREQVQAMRQRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE6</accession>
    <name>A0A139SLE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dolichol monophosphate mannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711974.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05275"/>
    <dbReference type="EnsemblBacteria" id="KXU35383">
        <property type="protein sequence ID" value="KXU35383"/>
        <property type="gene ID" value="AXK12_05275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="309" mass="34878" checksum="AD01AE4D09D748D9" modified="2016-05-11" version="1">MKKKITVVTPMFNEEDNVTELCDRVAAVMKNLPYDYEHICIDNCSTDKTVSVLRKRAAGDKSLKIIVNVRNFGHIRSPYHAMLQATGDAVVLIAADLQDPPEMIEDFVKKWEEGFKTVMATKPESEESPVMYFIRCVYYKIIGKISEVPLIPNATGCGLFDKEVIAILKGLSDPYPYFRGLVCEVSHPIATVPFKQPRRTRGVTSHNFYTLYDFAMLGITKHSKIPLRLMIFFGFALACLSFLAALGYLLAKLFFWHAFALGVAPIVIGFFFFTSVQMVFLGILGEYIGSIQTHVRNLPHVVEAERINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF6</accession>
    <name>A0A139SLF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711978.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05285"/>
    <dbReference type="EnsemblBacteria" id="KXU35385">
        <property type="protein sequence ID" value="KXU35385"/>
        <property type="gene ID" value="AXK12_05285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="274" mass="30312" checksum="775F769BC7626891" modified="2016-05-11" version="1">MPVLSNILSYANDIRLLALELCYRKRSSHIGGALSIADVLAVLYGKTLNIAPETISDSGRDRLYYSKGHACVALYAALALRAFFDREELLDKFTRDGAYFTSHVNHHLPGIELSTGSLGHALGVSCGSAIASKRLARSNIIVTIVSDGELDEGSNWEAILFAAHHQLDNLICIVDYNKIQSFGNVSDVMTLEPLVDKFRAFNWSVDVIDGHSVFSIHETLERLKVERSGRPKCVIANTVKGKGVSFMENKIEWHYRPPSENEFLKACSELKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG7</accession>
    <name>A0A139SLG7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">AXK12_05345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711997.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05345"/>
    <dbReference type="EnsemblBacteria" id="KXU35395">
        <property type="protein sequence ID" value="KXU35395"/>
        <property type="gene ID" value="AXK12_05345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="226"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="397" mass="41967" checksum="82FB9E935B434EE8" modified="2016-05-11" version="1">MAAKEDYYALLGVGKTATADELKKAYRKKAVQYHPDKNPGNKEAEEMFKKVSEAYDVLSDADKRAAYDRYGHAAFQGGMGGAGAGGFGGAGGGGFHDPFDIFREVFGRQAGGFSRAGGAGGGGFFDEMFGGGGGGRASAVRDGADLRYDLEITLEEAARGVEKEISYRRLVSCERCSGSGAEPGSKTVTCPTCGGAGQVRRSGGIITFTQVCPTCGGTGQKIEKPCTKCHGEGRVQQTTKLKVNIPAGVDTGSRLRSAGNGEAGVQGGQTGDLYIVLAVKEHELFERHGDDLFCEIPIKFTLATLGGSIEAPTLFGKATLKIPAGTQSGTTFRLREKGMPSLRGRRQGDQLVRVHVEVPTSLSNEQRKVLEEFATLSGDAPTEPASKSFFEKAKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM16</accession>
    <name>A0A139SM16_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaA</name>
        <name evidence="14" type="ORF">AXK12_04975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711863.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04975"/>
    <dbReference type="EnsemblBacteria" id="KXU35605">
        <property type="protein sequence ID" value="KXU35605"/>
        <property type="gene ID" value="AXK12_04975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="186"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="490" mass="54353" checksum="784B21149158B2FC" modified="2016-05-11" version="1">MPTATLAPSPWETAKTSLKQFFSEDVFKMWFEPLHCIELGEDTITLGVPNDFAAIWIQENYLDLISKHLSLAYGRELSITLQKAAPPQSAHAHRGHSDSAALLDGQGNARGSSGAVSGGRGVNDHAQTGTGFDRDASPRLGAAAPERRRPEATLNPRNTFDTLVVGANNQMAHAAAMAVAQAPAQAYNPLFLYGDTGLGKTHLMHAIGHAILQNRPDARVVYLSTERFTNEFIQALQENSLTKFRQRYRRASVLLLDDVQFLAGKERIQEEFFHTFNDLFESGKQIVLSSDRRASEIQQLEARLVSRFEWGLPADIQAPDYETRVAILRSKAATLKADVPHEVITFIAQRLSGNVRRLEGALIKVSSYAALTGRPLDIPTAEKLLQDVLIEQAQNLLTIDVIQKRVADHFQIRHSDMTSKRRPNNIAIPRQIAMFLSRKLTKHSLQDIGDAFGGRDHGTVIHACKAVDNMIEQDPSMRGSIEFLKTQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM47</accession>
    <name>A0A139SM47_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_04850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711818.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04850"/>
    <dbReference type="EnsemblBacteria" id="KXU35648">
        <property type="protein sequence ID" value="KXU35648"/>
        <property type="gene ID" value="AXK12_04850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="302" mass="33356" checksum="985D5A3D86B99F60" modified="2016-05-11" version="1">MPPRFDQARPFLTLALLLLVWLLVPVFLKSFWRASFFEFQAPIDATASYVRDLQEYWTLRAHSKHELIEAGRDLARINASYALAVQENATLRAQLDRQHALLQIPPPPEHRLEHARVVRRDFSAWWQRLIIRKGRNYGIPTGAPVVFAGGVVGIVSEVHAYTATVDLISSPNVRLAAVIEGDARPISYQGGLNPTLARPRGVIEFVPLDIAQTHSPTANTPNRNGAAPSAPPARRLLTSGLGGVFPAGLQIGQITQLRPNADGLFQSGEVTLDSRLSELREVTILVPTREREQTAEATAQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM53</accession>
    <name>A0A139SM53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_04845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711816.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35647">
        <property type="protein sequence ID" value="KXU35647"/>
        <property type="gene ID" value="AXK12_04845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="180" mass="19643" checksum="F7B9BB9823C0FD0B" modified="2016-05-11" version="1">MFRSAAFFLFASLVLLWAGLAQLNHALSPLHLHLFGGGLYVVFAALRLPSASGLILSCLAGLWCDAASPIPFGTHLVLFALAHTLIRKSRSHLDTRHTPSLVLVALLSNAALWIALTSFLITRAPIIARSAPRLLLDLLLSEALIALIAPWFFALQNRLLLIARHATGSTRPSDTFHNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM59</accession>
    <name>A0A139SM59_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_05065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711892.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05065"/>
    <dbReference type="EnsemblBacteria" id="KXU35619">
        <property type="protein sequence ID" value="KXU35619"/>
        <property type="gene ID" value="AXK12_05065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="175"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="337" mass="36969" checksum="FD979D243C9A0B20" modified="2016-05-11" version="1">MRHFLKETDFSAEELPKIFALAHALKQSRADFLGTGSAARVNSESRQLKGQSWGMIFAKSSTRTRVSFEVGIHELGGHPIFLSKSDIQLGRGETVADTARVLSRYLHGLIVRTYAHAELEELAANATMPVINALTDFLHPCQIYTDLFTLAERYAPAAAGGSAVSGEALVESLRGRKLAYLGDCSFNMANSWILGGALFGMQIALAGPEGFGPGPEIDALLAEAGLPKNYVFTSDPYEAVRDADVVYTDVWASMGQEEEARERQRAMEPYAVTRALFAAARSDAYFMHCLPAHAGEEVEQAVLDDPRSIIFDEAENRLHTQKAIMATLVEMNRHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM65</accession>
    <name>A0A139SM65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_04915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711836.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04915"/>
    <dbReference type="EnsemblBacteria" id="KXU35657">
        <property type="protein sequence ID" value="KXU35657"/>
        <property type="gene ID" value="AXK12_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="42855" checksum="92E02ADEB8C05A51" modified="2016-05-11" version="1">MSVSEKQGLPFRLAAPSCGEARPDLLVIAGEHSGDEHAARAVAALRARQSELHICALGGPRLAEAGAQLLHDLTASSVVGFVEVLRSYSFFKLLFEEILRWVVEYRPRAICFVDYPGLNLRLAAALRERGLSCKAGGDVRLLYYISPQIWAWKAKRRFAMARDLDSLAVIFPFEVESYADTELPVEFVGHPFLAADYESPVAYDPEAPILLLPGSRRQAVGRILPVLLRGLAAYEAELGAKTEATILYPSEAVLEEICAVGLPEHVRCVPRGSAAIRASAVLTSSGTMSLHCALAGIPGAIAYRTNPLTYLLARWWVRLDYIGIANLLLKEPMYPEYIQAAAKPEALAAELRACRSDPARRESTAAQAAQLRALLNRPANGTVADWLRRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM66</accession>
    <name>A0A139SM66_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711771.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04735"/>
    <dbReference type="EnsemblBacteria" id="KXU35676">
        <property type="protein sequence ID" value="KXU35676"/>
        <property type="gene ID" value="AXK12_04735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299314" evidence="2">
        <location>
            <begin position="27"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="33568" checksum="435FE07266128274" modified="2016-05-11" version="1">MIKKPVLVSFLLIAGALTLPPQAALAQPAAAPKAGPVASSPEAESLSERGLRLLVERQRMLFAEAAEREKAGRFDEADFTRQMQELCRAYDSLLSDNPKFAAAYAAYGYLLGKLGMEDEGVGMLLRANQYDPEIPLVKNQIGNYLAERGKPLEAVNYYLAAIRLAPDEPLYHYQLGTLLHNSRADFIRSGDWEAAAVDLASHEGFRRAAELAPERFELVYRYAESFYDLPEPDWDGALKLWGQLEAAAGSEIERQAIRLHAAKVCLESGRRDHARALLGTIDEAALAAQREKLIAQLERDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM86</accession>
    <name>A0A139SM86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711824.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35651">
        <property type="protein sequence ID" value="KXU35651"/>
        <property type="gene ID" value="AXK12_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="236" mass="24813" checksum="F330AEDB1A06A038" modified="2016-05-11" version="1">MKRVYGVVFLLAAAFVLPSPSTGTALRDLGEGLGYIRVLGEPERFALPSALSSEDQVQPALVLDLRYVGGGAAEAQQLSEWLSERAETSSVAPPIFFLVNGETALALGEAAAQFAQNYPALLIGAALADGGDFVPDIVLEIDAEEERAAYALLASSDPDIGGLIGEAAAAARKRRYDEAAVIAAHAAPESAHRPSRAASTEPPPEATVARPVDLALQRAIHLHRAWRALSSTRKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMJ6</accession>
    <name>A0A139SMJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35690">
        <property type="protein sequence ID" value="KXU35690"/>
        <property type="gene ID" value="AXK12_04810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="540" mass="60048" checksum="46F44D7560329935" modified="2016-05-11" version="1">MGWSGKAVAAEATPYKPSVSAQPQPRGPFSESAPETAAATVTEAAATETAPAKIELHIGHWLLHTGMREAFDATIEDYQRLHPEVRITQLPVPIRFYPAWARTQLVGGTAADITGMLALNEELISHYYLPLTEWLDTPNPYNAGTSLEGVAWRDTFFDGLNGMRALTATSGEISGVILQINSLRLYYNREMLIEITGSDTPPRDLADLQALAAKVDAYNQHSGKSIIPIAGCGPYAGYAFDRIVPSQTQRLTLDHSPARNLRVSPLELATLIIDSVFSYTKTPELRSSLELMREVSQLLTPGFMQLQRDEAIATYVQQRSLMLIAGSWDYAALIDGVPFETRALPVLGPSTADPQFGQFTLGQVAEPMDIEGSMGIIRSSPHPEAVLDFLHYLTSQRAAEKFSQISQRLSAIIDTPVPPNLAQIKSRLDGEMPGFTVDFRSFSTGHSGNHFQRYIHKIVGPKADVSGVAEHLDRELPRYLRDDIAAHLRHLQRDIQRLDATIALHYTLPPEHRARANWRRHSEVQHLRKFDALRYRPYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMY1</accession>
    <name>A0A139SMY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711692.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04600"/>
    <dbReference type="EnsemblBacteria" id="KXU35966">
        <property type="protein sequence ID" value="KXU35966"/>
        <property type="gene ID" value="AXK12_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="264" mass="28920" checksum="2A794BA02271D145" modified="2016-05-11" version="1">MSPHPSPAKKTGARKMSDTSAARLAELNAGAPTSNLVEQLSIDLAVLMETALPEIGADAIAQMRAASQLGVTQRMALAGKLLAAHFGEAGLGKALTHRSDTVRGWACYAVAALPDLTLEKRVALIRPLADDPHYAVREWPWLALRPHLASELEKAIGLLEPWTHERSEFLRRFASEALRPRGVWCAHITALKKTPALGLPLLEPLRADPSRYVQDSVANWLNDASKDSPEWVREVTSRWLAESPCAATQRIVTRALRSLRKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC0</accession>
    <name>A0A139SNC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">AXK12_04410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711609.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04410"/>
    <dbReference type="EnsemblBacteria" id="KXU36067">
        <property type="protein sequence ID" value="KXU36067"/>
        <property type="gene ID" value="AXK12_04410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="422" mass="44742" checksum="1F036D092F82F9E1" modified="2016-05-11" version="1">MAKLLPDPLPILPFTAPAPGSVTLPGSKSITNRALILAALAEQPVTLRGALFSRDTRIMVAALRALGFRVETDEAELTTTVWGLGGEIPNAEATIDVGNAGTAARFLTALVCLRKGGVYHFDGDAAMRARPIAGLLDALAQQGASADSQTFPFTLRTNGLPGGTVTLNASASSQLVSALLLVAPRATTPLRVELLGETVSKPFITMTERMVAQFAAQALSDYAIEGDATAASYFAALPIVTGGRVQINGLTLGPAALQGDTAFFSLLEEGKLITRVGEWVESLGKSHKRGLSADFNAFSDTFLTLAAIAPLLDGPTKITGIAHTRHQETDRVAGMARELRKLGQAVIETEDSLEIHPRTLVPGQVIETYHDHRFAMSFGVLGCHDLHGNGQPWLSIKDPGCCGKTFPHFFDVLEKLRRASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN4</accession>
    <name>A0A139SNN4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TonB_dep_Rec domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03815"/>
    <dbReference type="EnsemblBacteria" id="KXU36195">
        <property type="protein sequence ID" value="KXU36195"/>
        <property type="gene ID" value="AXK12_03815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="42"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="48099" checksum="EB72F651148AED65" modified="2016-05-11" version="1">MRVAGNYVNVKYKGQYVLAAPDFEVVSVDQLTGEWVWDGVTFNDNPAYITDGARVHEHGRQANFQNDFAYEFEGPSWKSKTVAGYALNWRGVYPRPSPSFEPNPNTYDLVAGERIPAGYTLRNTWGAGSASRNHDSQYYLYQVVNLLDDKLVLSGSLSYNEYASARQNYTSGARTKDTISTTLPAAGIVYKVTPQLSAYYGYSEQGVPDGPDFSNGVPHHVESSTQHEVGVRVRLADGKLYATLAYFDLKISDVYMWDLRNYTAPIPDPLYPAIKSDRTVDGVEFEFTWSPTPQLSFVGNIAHNKNRDGDGMQFANIADDSAAIWASYAFSDTGPLAGLRIGIGADYLGERAGTTHRWTTPPLGFTPVRIQPSFYVPSRTLVNASANYRINKHWSAQLNVTNLTDEDYIMGANGRGIDMGTPINARLTIRYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP8</accession>
    <name>A0A139SNP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711302.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03535"/>
    <dbReference type="EnsemblBacteria" id="KXU36223">
        <property type="protein sequence ID" value="KXU36223"/>
        <property type="gene ID" value="AXK12_03535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299295" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="141"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="33584" checksum="BF2A9DEF92909D35" modified="2016-05-11" version="1">MKKILSQLLLVLALLLSPSAPTLFAQGRATLPPPVAELQAIIEEFQARGGNDADVDEFFERIDLLLRKYAGDRSDGVAQVAAARAYMTLEILGDAERARSLFAAIPKDFPGTQIAAQIPSVLERLDERIAQAASEQASTDALIGQRAPELHFQWSTKNGLKKLSDLRGQVVVIDFWATWCGPCIRTFPQIRAEVARFAGAPVTFLGVTSLQGQVNNLRSRPIDTKNDPQREFSLTSEFMEKHGMTWEVAFSEENVFNEDYGIEGIPHMVIIAPDGTLRHSHLHPGDPKANVAGKVSALLKEFGLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS3</accession>
    <name>A0A139SNS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">AXK12_03920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711427.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03920"/>
    <dbReference type="EnsemblBacteria" id="KXU36208">
        <property type="protein sequence ID" value="KXU36208"/>
        <property type="gene ID" value="AXK12_03920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="201" mass="21312" checksum="1EA4CEC6C6A544C3" modified="2016-05-11" version="1">MRVVILGSGRGSNAEAILRAQAAGRLESARVVQIFSDQPDAGILDLGERFGVSARYLDPAPFKTKLEGAGESRYIAAIRECAPDLVVLAGFMRVIKLGFLDAFAGKIINLHPSLLPSFPGLDAIGQAWARGVKITGCTVHSVTAEVDGGPIIDQAAVRIEPSDTLETLREKVHAAEHTLLPSVIARLSKAVQPSPLPLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNT5</accession>
    <name>A0A139SNT5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711344.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03665"/>
    <dbReference type="EnsemblBacteria" id="KXU36245">
        <property type="protein sequence ID" value="KXU36245"/>
        <property type="gene ID" value="AXK12_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="188" mass="19420" checksum="A0FD0892C1F4605F" modified="2016-05-11" version="1">MLDTLFTVFATFALLFALGAVLSPNAINAALCFLLCLVSVAGIFVLLEAYLLAVLLVLVYAGAVVALFLFIIMLLDLKQVSAWKFRGISALAGVVGAGLLVAGVLAVATRGQLDSLPAAMIPALGADLKAYAHALFTTYLLPVQVMGFLLLAAMLGVIVLSKKFIAQGEAPAASPALDSQPATQAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ8</accession>
    <name>A0A139SNZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03910"/>
    <dbReference type="EnsemblBacteria" id="KXU36210">
        <property type="protein sequence ID" value="KXU36210"/>
        <property type="gene ID" value="AXK12_03910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="240" mass="25512" checksum="EC0E602F447F91A1" modified="2016-05-11" version="1">MNEPTALAVDDLYVSYGAISALRGISLNVPAGAIVTLIGGNGAGKTTTLQTLSGLVRAKSGRIHFLGEDITALAPHEIVARGLCHVPEGRMVFPQLTVDENLSMGAYLRKNAAAVAQTRDTVFTLFPRLKERLRQSAGTLSGGEQQMLAIGRALMSAPKFLMLDEPSLGIAPRLISTIFEKIVEINRSQGVAILLVEQNAKLALEISTHAYVLETGHIAMQGPSPTLRNDAQLKAAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP72</accession>
    <name>A0A139SP72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711256.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03410"/>
    <dbReference type="EnsemblBacteria" id="KXU36346">
        <property type="protein sequence ID" value="KXU36346"/>
        <property type="gene ID" value="AXK12_03410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="428" mass="44224" checksum="2DD9B0BD4F753B9D" modified="2016-05-11" version="1">MGQRVFITGLGLITSIGNDVPGVIASLRDLRHGIQLYPPFEPESVPVKVAAPVRDFDTASNDPEDWTYPAAYKIRREVIRGMAPHGVYAWCAMQQAIADAALAESDVGDNADTGLYAASGGSPQLMGHMLGRMHKLGVMRCSPLGIVAAISGTLNFNLVAHFKIKGPSCGFSSACASSTHALGYAYDDLVLGRAKRMFVVGAEDGNLDSILPFAGMRALSLSRDPATASRPFDAARDGFVGTGGAAVLVLETEAEVERRKSAGAAVSLYGEVAGWGQASDGHNVAISHPEGEGLALAMRRALAAAQLEPSAVDYINAHATSTPIGDLSEIRAIKAVFGEGGAGPKVSSTKALTGHGLSLAGAMESAFCALALREGFIPGSAHITQLDPECAGVNIPRQTLDEAPAVALNNSSGFGGANVSVVLKRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPE9</accession>
    <name>A0A139SPE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711238.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03315"/>
    <dbReference type="EnsemblBacteria" id="KXU36413">
        <property type="protein sequence ID" value="KXU36413"/>
        <property type="gene ID" value="AXK12_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="123" mass="14421" checksum="6FB2554C58D176A1" modified="2016-05-11" version="1">MDKLEEIFRMQEALNQRIGVTLPPADDEEKTRWVLNYTRAMQQETAELIDSVPWKWWAKYQKFDEQNAKVEVVDLFHFLVSLAQTLGMTAEDVYQAYLKKNAVNHQRQDSGYVAKDADDSKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPN1</accession>
    <name>A0A139SPN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPR_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03190"/>
    <dbReference type="EnsemblBacteria" id="KXU36482">
        <property type="protein sequence ID" value="KXU36482"/>
        <property type="gene ID" value="AXK12_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041656">
        <property type="entry name" value="TPR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12688">
        <property type="entry name" value="TPR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPR_5" evidence="1">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="148" mass="16177" checksum="B0B446BBCCA27FD1" modified="2016-05-11" version="1">MGSRHGGRVHELLAALSDLDARYPNIAEINYQLAWTYEVLDRETEAVPLYEKAIALGLPENELCGALLGLGNTLRLIGKTARAVEVLRSASAQFPDNKELDAFLALALHAAGEPTEALRTLIDILCETSEDTGITAYQRALRHHASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQB2</accession>
    <name>A0A139SQB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ORF">AXK12_02975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711168.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02975"/>
    <dbReference type="EnsemblBacteria" id="KXU36756">
        <property type="protein sequence ID" value="KXU36756"/>
        <property type="gene ID" value="AXK12_02975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="363" mass="39092" checksum="8C962107510AAE7D" modified="2016-05-11" version="1">MGNSFGTLFRITTWGESHGAGVGVVIDGCPPNLPLTAAEIQAELDRRRPGQSAIVTPRKEADALEILSGLYEGRTTGTPLSLLVRNTDQRPSSYDEMVEKFRPSHADYTYQTKYGRRDPRGGGRSSARETIGRVAAGAIAKKILSLTGGVEIRAYVAQVHDIAMAARADFPSLAEVEATAVRCPDAATAERMIARIKEVRSQGDSVGGVVECRVRGLPVGLGEPVFDRLEADLAKAMLSLPASKGFEVGSGFGGVQLKGSEHNDPFVMREGRVRTTSNRSGGVQGGISNGEELFFRTAFKPTATILQPQQTVTIRGENTELAARGRHDPCVLPRAVPIVEAMAALVLLDHWMRHSAQNRTFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQC4</accession>
    <name>A0A139SQC4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_03065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711183.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03065"/>
    <dbReference type="EnsemblBacteria" id="KXU36748">
        <property type="protein sequence ID" value="KXU36748"/>
        <property type="gene ID" value="AXK12_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="349" mass="36847" checksum="A8FCD2681B437F44" modified="2016-05-11" version="1">MAIKVGINGFGRIGRLVFRALVEQGLLGSTLDVVAVNDLVPADNLAYLLKYDSVQGRFNGTVTSEKSSPDAAEDDVLVVNGHKIKVLGERAGPAALPWGALGVDLVIESTGLFTEAEKARGHISAGAKKVIISAPAKGEDITVVMGVNDEKLDVAQHSIISNASCTTNCLAPIVSVLLKEGFGVEEGLMTTVHSYTATQKTVDGPSKKDWKGGRAAAQNIIPASTGAAKATALVLPEVKGKLTGMSLRVPTPTVSVVDLTVRTTKETSYAEICAAMKKASETYLKGVLEYTGDEVVSSDFIHCKASSIFDAGSGIELNSKFFKLVSWYDNEWGYSNRVVDLTKKIAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQH1</accession>
    <name>A0A139SQH1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711147.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36711">
        <property type="protein sequence ID" value="KXU36711"/>
        <property type="gene ID" value="AXK12_02855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299360" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="187" mass="20406" checksum="CDA2389881A2CE73" modified="2016-05-11" version="1">MKTYLLTLLALAGFALGTAQAQAASASPYVGVGLGYLIDSEEALITIRAGMELPSRSLGDLPDRFSHNLEFEFGYVDLGDNRVAYDLTTFFFNYRGEMTGLGWVPYFGAGLGFANADVGFWSNFIHYSDNDTVFAAQAFAGMKYNFTPAASVTLGARYLWVDDVKLLGLSARDTDDVGLEASFSFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQM1</accession>
    <name>A0A139SQM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711114.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02670"/>
    <dbReference type="EnsemblBacteria" id="KXU36876">
        <property type="protein sequence ID" value="KXU36876"/>
        <property type="gene ID" value="AXK12_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021342">
        <property type="entry name" value="DUF2959"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11172">
        <property type="entry name" value="DUF2959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299376" evidence="2">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="219" mass="24572" checksum="056D4AA76C8824DD" modified="2016-05-11" version="1">MKAALFLRLCIGLVFGASLAGCTGAYHRSLEQRGMTKRDVLVRRIQHVQSAQEEAKYQFTRALESLRSIAQVEPGRLREKHSELDAQHKNGSERARVLGKRLPAVDTAAATLFKEWEKELALYQNPALRAQSEQRLAATRADYAEFIRTQEAILAQIAPVLVSLRDQVLVIKHGLNPETRRELDTTLQALREELSGLIRSIDESTRAADAFIEALNTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQZ6</accession>
    <name>A0A139SQZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
                <ecNumber evidence="16">4.2.1.59</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">Beta-hydroxyacyl-ACP dehydratase</fullName>
                <shortName evidence="16">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
                <shortName evidence="15">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
                <ecNumber evidence="15">3.5.1.108</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">lpxC</name>
        <name evidence="16" type="synonym">fabZ</name>
        <name evidence="17" type="ORF">AXK12_02470</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="14 16">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LpxC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="16"/>
    <dbReference type="EC" id="3.5.1.108" evidence="15"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711076.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02470"/>
    <dbReference type="EnsemblBacteria" id="KXU37029">
        <property type="protein sequence ID" value="KXU37029"/>
        <property type="gene ID" value="AXK12_02470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU37029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="441" mass="48144" checksum="674CC18AB8408B9C" modified="2016-05-11" version="1">MKQRTLAREVSIQGKALHTGEAVTLTLKPAPAGHGIVFKRIDLSGAPELHPRIDQVGDLVRATTIQNGHAKIHTVEHVLSALHGCGVDNVVIEMDASEPPILDGSAKPFVNLILQGEPTEQDAEREYFTLDAPVSVTHGDSSIIALPANELKISCTSADNRGIHTQHLSLGIDPDTYITQIAAARTFTIYEDIEELLKLGKIKGGSLDCAVVIKGDKIISKEPLRFADEFVRHKILDIIGDIVLLGRPLKAHIIAMRPGHAINAELTKALFERLHEAKKPAKKKARPATLLPTETSLDIRRILDTIPHRYPFVMIDRVVEFIGDDELVAIKNVTINEPYFMGHFPENPVMPGVLQLEAMAQAAGIILLRKVTKASGTPFFMSADKAKFRKPVRPGDQVIINAKITKMRGEKLAVAECNCTVDGQVVSSAELMFAIVEEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQZ9</accession>
    <name>A0A139SQZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pemk protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711113.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02665"/>
    <dbReference type="EnsemblBacteria" id="KXU36934">
        <property type="protein sequence ID" value="KXU36934"/>
        <property type="gene ID" value="AXK12_02665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="108" mass="11666" checksum="105ABA5DF61FB3AE" modified="2016-05-11" version="1">MKRGEIYMVDLEPTAGHEQRGHRPVLVVSSEAFNRLTQCPVILPITNGGGFARRVGFAVPISGIKTTGVVRCDQPRVLDLAARNARKVDTLPPAIMNEVLAAAATLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR52</accession>
    <name>A0A139SR52_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein AXK12_02560</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02560"/>
    <dbReference type="EnsemblBacteria" id="KXU36931">
        <property type="protein sequence ID" value="KXU36931"/>
        <property type="gene ID" value="AXK12_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="138" mass="15248" checksum="EACC94F131B00867" modified="2016-05-11" version="1">MGGRGERLARAHLKACGYRILAVNWRSPSDRRDEIDLVVLDGEVLVFVEVKTRAAAALVSGRYAVDARKKRALRRSTYAYLRGLRKAPRSVRFDVVEVVLPKPDSGGGTGEPLIRHFKALPLFPKTLRLPGGEGLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRI9</accession>
    <name>A0A139SRI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-alkenal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711025.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02185"/>
    <dbReference type="EnsemblBacteria" id="KXU37157">
        <property type="protein sequence ID" value="KXU37157"/>
        <property type="gene ID" value="AXK12_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070569">
        <property type="term" value="F:uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="PTHR11952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="485" mass="53085" checksum="DEAA04F31E8D39B8" modified="2016-05-11" version="1">MSTHPLIDAFHAAGQGQVFRFFHSLEEAARERLLAQAAEVDLAEVARLKAKLLSGESGGAAQRVDLSDLSPAPYEPLPEHGGDAATWAEARVVGEAALRAGQVAAFTVAGGQGTRLGYDGPKGSFPVTPLRRKSLFQVFAEKLLAAEWRYGRPLHWFIMTSHQNHEATLAFFAQHGHFGLSPERVHFFTQGRMPAVDFEGQILLEAPDRIAMSPDGHGGSLRALASHGALELMEREGIDTLSYFQVDNPLVRCIDPAFIGWHRLKNSEMSSKMLPKAYAGEKLGHFCMQRGRLVVIEYSDLPTAMQEARDPATGGLCFSAGSIAIHLLDREFIRRMSAGAGVGSESLQFHRADKKIPTLDVEGQPVMPAEPNGVKFELFVFDALPFARNPLVIETSREDEFASVKNAEGSDSPKRSCEAQLRQAARWFAAAGERLEVDESGLPKIAVEVSPLFAVDAESFCESWRKLSPRPSIVDGLYLEAPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRM9</accession>
    <name>A0A139SRM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711016.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02135"/>
    <dbReference type="EnsemblBacteria" id="KXU37236">
        <property type="protein sequence ID" value="KXU37236"/>
        <property type="gene ID" value="AXK12_02135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="58"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="589" mass="64450" checksum="A33635E9C9F62865" modified="2016-05-11" version="1">MPKQERSPDTRHPIAIEVDRLSKTYRVWETPLSRLRVSFLEACARAARRLLGPKSPLAERIAVAAQHGFREIQALRGVSLQIGRGEVVGLIGYNGSGKSTLLQIIAGTLSPTSGRVEVRGRVAALLELGSGMNPDFTGRENAYLYGSILGVSRQFLESRMHAIETFAEIGQFFDDPVRTYSTGMAARLAFAVLTQLNPDILIVDEALSVGDAYFQHKSINLIRQFQQAGKTMIVVSHDAATIKTMCTRAVILEHGNLIREGPAIAVCDYYNALVAKKQKDLEIRQVERAKGHTVTRSGDRRVVIGDVELMNASETPTRSFTVGENARIVCALEFRDAVEAPTVGLLIRDRLGNDVYGTNTHHQGVALGDFTAGQSAEVRFALPLRLAPGRYSLTVAAHSGHTHLAANYDWQDNAVVFSVLPGAEAPFTGTAFLPTTVDVSRDKVAPLRAYQWGHTLSFSADGDAVRYKLHGWAIAEDEFTWTEGPEAALRFDLPASPKRNRTLKLCAGAFCTSEIPAQRVRIALDEHELGQLQISETREYSLALPSTLIATQARHQLSFKLPDATSPAALGICDDSRLLGLQLFSLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRS4</accession>
    <name>A0A139SRS4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_02115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711012.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37232">
        <property type="protein sequence ID" value="KXU37232"/>
        <property type="gene ID" value="AXK12_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="273" mass="29327" checksum="0EC30263A6C36048" modified="2016-05-11" version="1">MNAKVTPSSRSSFPFLPCIISVALAILAGCYVNPVTGRSYTVLTSVGEEVRMGAQAFNGIKEEEKISRDPAANARVQRIAGRLAEVIGEAVPEANWEFVVFDSDTLNAFALPGGKVGVYTGLMALLDDDDELAAVIGHEIGHVVARHGGRRMSQGMIVGVIGAVGGAMVENTELFKQAYGGITNAAFVLPHSRKDEQEADLMGLHYAALAGYDPEAAVRVWQKMDAVSDHENAPPAWLSTHPTNAQRIADLSKAAPKYRETYLANKDRFADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRZ8</accession>
    <name>A0A139SRZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710957.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01845"/>
    <dbReference type="EnsemblBacteria" id="KXU37369">
        <property type="protein sequence ID" value="KXU37369"/>
        <property type="gene ID" value="AXK12_01845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="30351" checksum="C5F6281F8D84D3F9" modified="2016-05-11" version="1">MLLADALLEPFRYPFMVEAMLAGAAIAAVCAVLSCYLVLKGWSLMGDAISHAVLPGLVLAAVFGLPLALGAFLSGLFCAVSAGFIKAHSRIKEDTVLGVVFTGLFAFGLVLFTKLQVDIHLDKVLFGNILGLLPGDLHATLITSAGVLVVVVALRRDLLLFCFDPAQARVIGLRTGLLYYLLLSLLAVTIVVALKAVGILLVVAMLVTPGCVGFLSTARFGKMLCVAVGCAVGSTLLGIYVSFFLNASPAACIVLVQVLVFFAAMGLRKKRGLSPKTRFPALAQILNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS18</accession>
    <name>A0A139SS18_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ORF">AXK12_01965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710976.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01965"/>
    <dbReference type="EnsemblBacteria" id="KXU37389">
        <property type="protein sequence ID" value="KXU37389"/>
        <property type="gene ID" value="AXK12_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="59" mass="6748" checksum="5FFC3534949323A2" modified="2016-05-11" version="1">MAQPKRKQSKRRSANRRAANAFQAPEFAKDPTDGSLFRPHHVNPKTGMYRGRQVLNVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS39</accession>
    <name>A0A139SS39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH dtxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01820"/>
    <dbReference type="EnsemblBacteria" id="KXU37409">
        <property type="protein sequence ID" value="KXU37409"/>
        <property type="gene ID" value="AXK12_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="132" mass="14368" checksum="05AFAD3CC0BC4DA5" modified="2016-05-11" version="1">MRAAALRCTREAHSRETVEDYVEAIADLVARTGEARVTDLARELGVSHVTVNRTIARMQRDGFVSSLPYRAIFLTETGKQLAAESKARHQTVEAFLRAIGVPAAVAQKDAEGIEHHVSRETLAAFAKLAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS53</accession>
    <name>A0A139SS53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YjgF_endoribonc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710960.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01865"/>
    <dbReference type="EnsemblBacteria" id="KXU37373">
        <property type="protein sequence ID" value="KXU37373"/>
        <property type="gene ID" value="AXK12_01865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="153" mass="15638" checksum="8DBCCAD4EA0AE031" modified="2016-05-11" version="1">MNPEQKLASLGLSLPNAPAPVASYVPTVRTGNLLYCAGTICMVDGQMTHTGQVGKTQTLASGAEAARVCALNTLANIKAAVGSLDQVARIVFVSGFVNAVDGFEDSPAVINGASDLFVNVFGEAGKHARAAVAVNGLPKASTVEIQVVVELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS63</accession>
    <name>A0A139SS63_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">AXK12_02020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710984.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02020"/>
    <dbReference type="EnsemblBacteria" id="KXU37398">
        <property type="protein sequence ID" value="KXU37398"/>
        <property type="gene ID" value="AXK12_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="435" mass="48376" checksum="D844B2CE28C38793" modified="2016-05-11" version="1">MSAFQTLPGFREFYPEELLRRNYLFRLWRQTAVNFGFSEYDAPVLEALELYKAKSGDEIEAQLFSFTDKGGRAVTLRPEMTPTVCRLVGAKANALKRPIKWFSIGEFYRYERMQRGRGRCFFQFNADIFGEPGVEAESELIGLLVQNLCAFGLTEADFFVRLSDRDLWVYYLSALGLDEPRIKAVLTAVDRYEKHGEAAFKAYAEVFGEIPAELKTRVVEFLGVKSLDGLEAILAALGDERIVARLGEWRKLLGNLEAMGLSRFVQVDLGVVRGLAYYTGFVFEAFDRKGELRAIAGGGRYNDLLGKLGYADMPAVGFAIGDMTFALLLEQRGLMPPLLSAPDVYCVIGDGEAERHAALGAIQSLRASGLRVEYSLKPLAFGKQFRAATDAGARIALIFGGDEVARGVLKLRDLNERSEREVPLAAVIESVRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS81</accession>
    <name>A0A139SS81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37403">
        <property type="protein sequence ID" value="KXU37403"/>
        <property type="gene ID" value="AXK12_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="17722" checksum="5BDE81B65195BD54" modified="2016-05-11" version="1">MGCDLPKIHIEWDDAHAAGLTLELRTYRQIVSRLGSHEGVETSLDTQDADGRHWGREPSDVLENTRESSECAGSVLHDVRAMCRSLGRLRDLGATVTIDGREATVAALDAYEDTLAREVCRLGSDASADSGDRAVNGERGGSFLSTIVYVVGLAVVLQWVFSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS92</accession>
    <name>A0A139SS92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710970.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37384">
        <property type="protein sequence ID" value="KXU37384"/>
        <property type="gene ID" value="AXK12_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="115" mass="12803" checksum="FC06733F8E009DBA" modified="2016-05-11" version="1">MSAAELHSLHILHVFAVFVLIGTTFFACAGPAETRKRVLMWSGIASLVVLLTGFRLWQGLYGMAGMWAVVKLVCWLGLSAFGGVAYRRREKAKLWLRLTLVFAAIALVMVYLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSA2</accession>
    <name>A0A139SSA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710980.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37394">
        <property type="protein sequence ID" value="KXU37394"/>
        <property type="gene ID" value="AXK12_01990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="286" mass="30744" checksum="C57513DAA5C36A6B" modified="2016-05-11" version="1">MLYLLLASLAWAFSFGLIKDQLTALDPTAVVVLRLLCASLVFLPFLKLRQISLAQAGRLAAIGALQFGLMYVIYLRAFAFLAAHEVVLFTIFTPVFVALLDAVIERRWAWRHFGAALLAFIGASLMLWNSLALSGIALGFGLMQVSNLCFALGQLAWRRERARAPQLSEAALVGLLYLGALGAALAASLVTTDWLAFRPSAAQLGIIAYLGTIASGVGFFWWNLGACRVNAGTLAVMNNAKVPIGVFVSLVFFGEDADLTRLLLSGAVMLAAVALAEGWFEKTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSA5</accession>
    <name>A0A139SSA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710941.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37427">
        <property type="protein sequence ID" value="KXU37427"/>
        <property type="gene ID" value="AXK12_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="19783" checksum="E3EBF3372F86E854" modified="2016-05-11" version="1">MNHFTFTQQFREIYDRALALYTEGRRGAESYFTPEELAFLTANGITAQHVYDYVEDLHDEGGPDYDTALSIEIIRRDYFLNVQNGQWTGKKDDPATWPTKDESIWLPRLLAKARAKLHGELPDSGMFCCAGDRRFLAKNNIHPSEFMNLVWRAGDDDQAIIDFVAARSKTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSD9</accession>
    <name>A0A139SSD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpE</name>
        <name evidence="14" type="ORF">AXK12_02035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710986.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02035"/>
    <dbReference type="EnsemblBacteria" id="KXU37400">
        <property type="protein sequence ID" value="KXU37400"/>
        <property type="gene ID" value="AXK12_02035"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="230"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="497" mass="54398" checksum="48976C3100730443" modified="2016-05-11" version="1">MNIHPSRDAFVELATHGNVVPVYTDLMADFETPVSAYAKLRNAGPAYLLESIEGGERLSRYSFIGCRPRKVFACGPETTQIREPAAAEPVRHVPTPADPLKLIEDEMARYRPVRLPELPSFTGGAVGFLGYEYVMRIEPTVPVAPRDELGLPLLYFMLSDTLLIFDRAKQTLRLCVNAHIGDDEDAAQAYDRAVNEIDALYEILRQPAPLAPVPLPESPPIKVPSGNFTQPDFEAAVETAKGYIRAGDIIQVVGAQRFSKPFAQSPLDLYRALRTVNPSPYMFILETGDFSLVGASPEVHVKLTDGLVEIRPIAGTRRRGATPAEDAALERELLADEKEKAEHLMLVDLARNDIGRVCEYGTVTVPDFMTVERYSHVMHIVSQVEGRIAADKNAFDLMRATFPAGTVSGAPKVRAMQIITELEQLQRGFYAGALGHFGYDGNTDTCIMLRTALIKDGQVYIQSGGGWVADSTGEGEYQESINKASALFKAVGVAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSE8</accession>
    <name>A0A139SSE8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710936.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01725"/>
    <dbReference type="EnsemblBacteria" id="KXU37422">
        <property type="protein sequence ID" value="KXU37422"/>
        <property type="gene ID" value="AXK12_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="106" mass="11489" checksum="0DDD314778D867A6" modified="2016-05-11" version="1">MSDKILTLNADNFKATIAADTPVLVDFWAPWCGPCKAIAPILDELARELDGVQIAKVNVDENEQIAAEYAIRAIPTMLIFKGGQVVEQIVGMTPKDALKAKLTAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSK8</accession>
    <name>A0A139SSK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="9" type="ORF">AXK12_01800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01800"/>
    <dbReference type="EnsemblBacteria" id="KXU37440">
        <property type="protein sequence ID" value="KXU37440"/>
        <property type="gene ID" value="AXK12_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="8">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="194"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="442" mass="49084" checksum="6FA424E045E2E6D6" modified="2016-05-11" version="1">MPDPSRFEDLAALDALAAGLAESAHAPIYLDHVYALALAELNTFARSLGITFEGTLNRAQLIELIFKNAAEAKRPLRDRGYIDINAQGAFIVHTHVNYRLYPEDAWLPECLIKRYGLKRGHRVEVLVAPPSEGERCPAVVRIESVMGGAPEEISKVTPFEELVPYYPLQRILLEAPAVQRDVSMRAVDILTPIGFGQRGLIVAPPRTGKTILLQNIANSVAENFPDYTLILLLIDERPEEVTDFRRHTKGEVVSSTFDEAPESHVHCAEMVGEKARRLVEQGKHVVILLDSITRLARAYNALASNSGKIMSGGMEATALQKPKRFFGAARNIEGAGSLTIIGTALVDTGSRMDEVIFEEFKGTGNMELHLDRGLVERRIFPAINIDRSGTRKEELIYHPEELQKIYGLRRAMQGLGPIESMEMLIKRLKATKSNAEFLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSS8</accession>
    <name>A0A139SSS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710881.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01435"/>
    <dbReference type="EnsemblBacteria" id="KXU37629">
        <property type="protein sequence ID" value="KXU37629"/>
        <property type="gene ID" value="AXK12_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="163" mass="17330" checksum="5D68404DA8BA0B15" modified="2016-05-11" version="1">MSFIYERTIRLADTDAAGVVFFANTLALCHEAYEAALAAAGCPVADFLGRDSDVLIPIAKASTDYLRPLFCGDLVRITLRPTRLSEESFAIDYEIVGGSGSVRRPALADKAGALVAANASALGAAEPRPKVAARARTEHVATSRSKRCRIPVPEKLAAWVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU3</accession>
    <name>A0A139SSU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MR_MLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01425"/>
    <dbReference type="EnsemblBacteria" id="KXU37627">
        <property type="protein sequence ID" value="KXU37627"/>
        <property type="gene ID" value="AXK12_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="299" mass="32742" checksum="2E51D1301A4589B6" modified="2016-05-11" version="1">MAPMPQDTSPREVAALLPAGRSALEALRARQAEGFRVFKWKVGVARDPAEELDILEELCAELGQARLVSVPTRPRDLERGESRESATTPAVAQRRLRLDANGSWTQRIAEQWLTRCAEPRLAARIEFIEQPVWDGETAGERPGGVAYNARGGSAQKRRVDDVLRGLSADYPTRLALDESVSSDGELRRWLGCGWQGVYVVKPTLLADPAAVLGELARAEARVVFSSALETAVGAKAALRWAFAWQGQQGDGGAGERYALGFGVYPLFRDAVFNGPRAVPFLRWEDVEGIDEEGLWNALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSV8</accession>
    <name>A0A139SSV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710899.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37647">
        <property type="protein sequence ID" value="KXU37647"/>
        <property type="gene ID" value="AXK12_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299374" evidence="5">
        <location>
            <begin position="21"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="57"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="290"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="769" mass="82812" checksum="BBA3B2C123EE655D" modified="2016-05-11" version="1">MNKAKLSALAALLAAACAQAAVAQTAPTNPPGVDVTEIQVEAERETLAVVQTEPPAGTFTSISAQEFAQRGATDMGGVVRYEPLVNAPSMASGQGGLWDGSGYSGYNIRGLEGNRVSMDIDGIPIPDAAQRPDGTSMNGFGIGRDYYEIENYRSVGIASGTTFAGRGNASIGGGVSFATKSPADLLGRSDRPFYLGYKAAYASVDESLSHTVTGAVGQGEVSALVIYTRRDGEERRSKGTGIVNPLDWSSDSILTKLVWDNATAQKLEFTVEHFKRERDLVAINKIGGFYPEAPLQHSETERFTLNLKHTFVPVGGLPVFDQLTTMAYWQDAVNGDHTRARYTFGGDFNRDIKTKFNNDSLGGKIDAIKRIGAHHTLSYGLSYSEVKTNRPWREIRTNRSTGAVVPAATGTKDRMPSMKTEEFVAHLSDEITFHIGSHRATLTPGLRFDSVDVKPTDLSRYINGVPAARNEIKAESDDFVTPSIAAELELTEKLSAYGSYKRGNRLPRPVEKTGTYDSFSYTGSGNGYAILGNPNLDKETSDAFELGLKGQALNGLSFQVSGFYTAYKDFIEYVTQPLDPINYPTISFLLVRPENVGDADIYGVEGTLKADLGAWEPALTGFSAILAAGRAQSSVDNKVAGVKGRLGSVGPFKGSLTLAYDAPSKRFGGALTATRVNGQQQGADTLAGPPFTTTYFDVPSVTTLDLAIYWQINDYTTLNAGAYNLTDEKHWDYYNARGLAAPVTAAQIAEVERYVQPGANFYVSLSIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST53</accession>
    <name>A0A139ST53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01550"/>
    <dbReference type="EnsemblBacteria" id="KXU37650">
        <property type="protein sequence ID" value="KXU37650"/>
        <property type="gene ID" value="AXK12_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="252" mass="28526" checksum="884D7CB0EFB959F1" modified="2016-05-11" version="1">MAEPAVPHATHQVPAHIAIIMDGNGRWAQQRGLPRIEGHRRGVETVRRIIDATREFGVRMLTLYAFSAENWRRPQDEVGALMRLLELYLKRELKTFVKNRIQLRTIGRTHELPPGAQRQLARTIKATRDFSDYTLTLALNYGSRSEVVDAAHSYAAALAAGEISPSDRSWESFSRHLYTGDLPDPDLVIRTSGETRLSNFLLLQAAYAEFVFTPVLWPDFGRDDLAQAIAEYSRRERRYGKTSAQCGGSDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB3</accession>
    <name>A0A139STB3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710843.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01250"/>
    <dbReference type="EnsemblBacteria" id="KXU37817">
        <property type="protein sequence ID" value="KXU37817"/>
        <property type="gene ID" value="AXK12_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="325" mass="35457" checksum="0F961681EC9DDFD8" modified="2016-05-11" version="1">MPTITYREAVRHALAEEIERDEAVVLLGEEVAQFNGSYKVSEGLLERFGPKRIVDTPISEAGFIGMGVGASMLGLRPVMELMFWSFYSVAFDQILNNAANVRYMSGGQINCPIVIRGPANGGTNVGATHSHTPENVLANHPGVKVVVPATPYDAKGLLKSAIRDNDPVMFLENTLLYGEKGEVPEDEYLIPLGQADIKREGTDLTIVTYGRCVLHSLAAAETLAAEHGLSVEIVDLRSIRPLDIDTVLHSVAKTHRVLIVEEQKPFCSVATQLAYMIQRDAFDELDAPIKRLSTIDAPAIYSPPVEIEQLPNPKRIIAAALDAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STJ6</accession>
    <name>A0A139STJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37834">
        <property type="protein sequence ID" value="KXU37834"/>
        <property type="gene ID" value="AXK12_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1195" mass="124402" checksum="7A2927817EAB3260" modified="2016-05-11" version="1">MGSAGAFVAVIAVFLGGGVGLTSAQILPPATAYQWSGGAGTSAWTDPQNWLGGVVPPDESEVLFGNVPSGAAGEAKLVENSLTNRKLRALWFESGFDYTLSGESLWLGDTLADDGRLITVLNREGRHSEIVINSAVNVSTLNPTRVFRIYNESLGGLRFNGSFNTGGHTILVEGTAGLRFAGAISGAAGMAGELRVAMSGGPAVFAADNSAWAGTINIDAGMAVVTANGALGSTALVTRVADGATLAFRQANLGEGLLLNYTSAKTLHLTGEGVWRWGFGNVGALYSDGGRNSFAGDIVLMGDAAIGARMDTLRLTGAVTGNGSLTKLGRGIVSLANAGNAYTGATIIREGGLLIESEAALPGGFDKTDTGTNIVLAGGVLVFQTSPYQFKRQLGTGPGQIQWTGSGGFSATGTGNAAYLTLTNEDGVAGGKLTWGQGGFVPFGSAFLFGSEYSAGTVELRNAVDLAGGQREINVHRNSVGSFIGNFTNGGLIKTGDGLLMIRGGLLYTGPTVIREGAFIVPENQAIATNFQLGGGTIMLAGSGTIGETAVNLGAGAGQVQWQAGRDGGITVFGGLVQTLRFNGSQAEITWGQEYFVGLDNTLIFGHRDNSPALILDTALNLAGGERTIRVIDGIAQFGPGPLYAELKFTQALRNGSLRLVGDGRADMAVANDELEGSVTVEDAELRLNEGGSLSAISALRAERSGIITLDNAGTNTAATGGVNLTDRVRDAATVTLDAGSFRFWGSDAADAVSSETIGAVTLAGGDNTIDVVNRSSGASGSATLNLASLTRSDDTATIRFTNSAGIGRYTATAPGPRLRFATAPALSGGILPWATVTDGSFGTHWATVTSDRYLVAYSESDYKTTAPSTWTATDNVSIDQFYYGIGQLKVNSLRFGNWAQLNFQFPNASTVLDIISGGLLAANGGYMQFGRVTTSADVLHIHIPSPTVNTQLDISSEIFGSAKLVKSGEGKLLLWGQQANTYTGTTYVNGGILALHKTGGGNAIVGDIVVGDFAGEDFLLIAASHQIADTAKVTLRGVWPKQPTDFGGFHEGILQLNNGNVLPGVREAFDTLHIEGRGVINFAGGEVTRANYLYLNHLTFADADSRLLIRKYVEQADYLLIRRTSASAVALGQIIFADYGPARFAPFDEHFIRITPFPEPTTYGAIFGLVGLALWAFRKKQGLKTRAPKMRVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STL4</accession>
    <name>A0A139STL4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710826.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01150"/>
    <dbReference type="EnsemblBacteria" id="KXU37800">
        <property type="protein sequence ID" value="KXU37800"/>
        <property type="gene ID" value="AXK12_01150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="30564" checksum="7410EA2D024674B7" modified="2016-05-11" version="1">MSSSSRSTPHRNTKAKPLAGRRIAITRAREQAGELSAKLAALGAEVLELPLIKISQSIDKQELADVLLEFGSYDWIVFTSANGVRYFFQEFFRIFDDIRSLGLLRFAAIGAGTAREIEALRLKVECKPKRATGGALAEALIETGSLDNAKVLVITGNLNRDELVQKLEAARAIVDRLQVYKTEQVQLASDEVAHGSAAAGTDSAIADFRARGADCVLFASSSAVTSYADQAASLRLADGAKPPLFGSIGELTTQTLLQRGLPLAFEAREPSLDSLVDALTEKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STM0</accession>
    <name>A0A139STM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37810">
        <property type="protein sequence ID" value="KXU37810"/>
        <property type="gene ID" value="AXK12_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="322" mass="35623" checksum="E89811400A5B637D" modified="2016-05-11" version="1">MFRFSRSFSPAGFWRAFWCAWVLAFVSAGGGAICSHAVEAGWPEREGEEVLRELRSAAIDGDYHLRFELKVLPRRGKARVLSGELWGSRNAEGPVSRVALYDGAAPRAQAGAAPRAPALAAEVEGAGAVSAAKPPARTLLIQNGVAPRIWVYEAGMASAEPLPESEWHAPLLADAEISAFDLLMPYLYWEDFDFEGGDKVLGRAAYRFLFREPVRAEDASGAGTSPSERLSVRAYFDQQFHALLQSKLIGPDGAVTKTLTVRDLQKKSGQWMLKSIDLRNERTRDKTRFEVREAELGLALEPWIFKPEWLGEPVTLPEPKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP4</accession>
    <name>A0A139STP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710809.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01070"/>
    <dbReference type="EnsemblBacteria" id="KXU37978">
        <property type="protein sequence ID" value="KXU37978"/>
        <property type="gene ID" value="AXK12_01070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="250"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="401" mass="43226" checksum="153A5AC2B9B61522" modified="2016-05-11" version="1">MKPHVNRCWAQIDLAALERNLRRIRATLPAHMRYVAVVKADAYGHGLHHAAARMMHSGADLFAVANVAEAAQLRELGPGWPILVLSPLLLEEDPLLAELDLAATISSAQEIARFDAVGRAAGRRLKVHLKIDTGMGRLGVWHTDAHALYAQITAAPHLELAGIYTHFASPDEDAAFTAEQRHCFLDALSRCEALGLRLDQSLFIHADNSAGLGTLPEGGRPFNAVRIGLLQFGIQPAPHALLTQVHTEPVFSFHTRIGLVKELPAGTTISYGRTHRLARDTRVAILCAGYGDGIPRALSNRGQVLVGGHRCPILGRVTMDQTILDVSALPAVACGDEAVLIGTQPTPNTAQPSSEPAATSPAPLAQIDIGEFSRWADTIPWEILCSITKRVPRLYQSPLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU00</accession>
    <name>A0A139SU00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710743.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00680"/>
    <dbReference type="EnsemblBacteria" id="KXU38056">
        <property type="protein sequence ID" value="KXU38056"/>
        <property type="gene ID" value="AXK12_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU38056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="345" mass="37515" checksum="87817A64AC66EBC5" modified="2016-05-11" version="1">MTPDANQNPPAQPLLEVKGLKMHFPVREGLFLRAKRSNRAVDGLDLSLATGETLGLVGESGCGKSTLGKCIVRLYRPSAGQILFQGRDLAHAKGAALKAQRRHLQMIFQDPVESLNARHTVADIVAEPLVIHGIGDAHSRQRKVRELLDRVGLPANAAERFPFEFSGGQRQRIGIARAIALGPRLIVCDEPVSALDVSIQSQVLNLLLELQHDLGLSYLFIAHNLAVVKHVSDRVAIMYLGKIVELADAEEIYRNPRHPYTRALISAIPEPDPLRSAHKQRIVLSGDVPSPINPPSGCAFHPRCPHATDRCKHEAPALRALASTEAAPGAATTASPHHLSCHYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU10</accession>
    <name>A0A139SU10_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">AXK12_00900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710779.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00900"/>
    <dbReference type="EnsemblBacteria" id="KXU37950">
        <property type="protein sequence ID" value="KXU37950"/>
        <property type="gene ID" value="AXK12_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="378"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="381"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="433"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="487"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="880" mass="92557" checksum="5E6D8C97531D5652" modified="2016-05-11" version="1">MSIRIHELAKKIGMDNKQLLKLLQGRNFEVKSVSSSIDNISADALVAEFAKPEDASAPQDAETAVKTSARSKAAAETASSESEAASTPGAPATPTVNLPAGVFVKTPEDIAREKAEKAAAAEAEAAALAAEKAATRAQAEAAAREPKPVATPPPAAAPVAPSAAVSAPPKLPPLPKPVPRAAPSIAAKPSATSTASAAPLSVPPVLGARPPVKESSPAQPPVKPAASAPPPPPVLSAPPSIATTAPRPITGAAAPVPPPLPPVAGAFAPKPPPIAAPLAAAASSSDDQEIKHIQLKPPIIVRDFAAALGLKPFKLISELNQQGGFASMNSTIEEAVAIAVAENHNFILEIKHRGEAAEKKVVQEKADPEEEEKRNLESRPPVVCILGHVDHGKTSLLDRIRSANVVSGEAGGITQHIGAYQVEKEGRKITFLDTPGHAAFTKMRARGAHVTDIAVLVVAADDGFMPQTDEALKHAQKAGVSLIVAINKTDVKGANIDQVKTQMQQRNIAAEDWGGETITVPVSALKGEGIDTLLEMILLQADMLELKANPKAEASGIIVESEIDFGRGPMATVIVQRGTLKVGDALVCGTHYARVRAMFDDQGRNIKAAPPSTPVRIIGWSSTPDSGATFRTAKNARDAEDQAETERLRIRQVATRAASAPKEVSVDQLFANIAATQARTLKVILKTDVFGSTEAVRNVLESIKSDKVQLDIIAAEVGLVTKNDVLMASAAKALVIGFNTKLENGVTSMAKHHGVRIESFELIYELGDKVRELMADLLDPDLKEIKLGGAEVRQVFELGKGAVAGCLVTDGKITRNVLARLRRKKGIVHEGRVSTLKRFKDDANEVRAGLECGIKLDDFNGYEVGDLIECYEVQKVRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU17</accession>
    <name>A0A139SU17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710803.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37972">
        <property type="protein sequence ID" value="KXU37972"/>
        <property type="gene ID" value="AXK12_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="255" mass="26746" checksum="44F8AD39971E94E1" modified="2016-05-11" version="1">MNRFNDKVVLVTGAASGIARATVEYLNDNGARVYGIGLEANIAQGFYAGRDPSSCVFKETDVRDTAAIQSAVDDLQSRFGRLDAVVNCAGIYPNGKRVEELSDEEWDNALAINLTSIFKVCRATMPLLRRSGGGSVVNIASVHAEATVPGVPAYAASKAGVVGLSRQMALDYAVDRIRVNAILVGSVATRITLDDIKAAGGAEALGLTFERNSIARIADPVEIATSIGFLISPEASFVTGSALQVDGGLLARLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU68</accession>
    <name>A0A139SU68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710760.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00740"/>
    <dbReference type="EnsemblBacteria" id="KXU38064">
        <property type="protein sequence ID" value="KXU38064"/>
        <property type="gene ID" value="AXK12_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU38064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="261" mass="29885" checksum="AF041DC5517F7D44" modified="2016-05-11" version="1">MAEMWGWDSFCQKVKEAGYDGIEGVPPATRESRELMFAAVHKYGLRFAVTCGCFEPGDYTQQSVGYKALLEDMVQLKPDFINCQTGRDHYSFEQNKVILDIADAISRDSGIPIYHETHRSRFNFAAHITKDYLEKIPELSLTLDISHWCNVHESMLEDQQDAVSLALSRTTHIHARVGHHEGPQVNDPAAPEWKDILGQHLRWWDEVVAQRIAQGQTQLSITPEFGPPSYMPTLPYTCQPLADQWQVNLFMFKLLKARYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUD4</accession>
    <name>A0A139SUD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="4" type="ORF">AXK12_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710748.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00720"/>
    <dbReference type="EnsemblBacteria" id="KXU38061">
        <property type="protein sequence ID" value="KXU38061"/>
        <property type="gene ID" value="AXK12_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="163" mass="17787" checksum="52CCDD050BB9D5BD" modified="2016-05-11" version="1">MKKESSTLQLVRQICRALDAKKAEALRVSDVRAYSSITDYIIVATGTADTHLRALRVELEKVLDAAGAQILGMDGQRESGWLVVDAFEVMVHLFLGETRQHYRLEQLWQDAPTLDVAELIEEPKPAARAAAAPKKKAVSAVKKPAAKPTKKKAAPKKSAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH93</accession>
    <name>A0A139SH93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_08400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU33916">
        <property type="protein sequence ID" value="KXU33916"/>
        <property type="gene ID" value="AXK12_08400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="393" mass="44335" checksum="7377390A7CE8D5E9" modified="2016-05-11" version="1">MPAEDAIMPTGSAFISQHLPGFKHMRVPNRWLILGLAGSWGLILLASSTEGRRTKITGICFLGAVTLLNLPNIPRKLKYDISQREQFHRIERDFIGDLSRGVLEGEKVAFLPWGNDFLVNYAAARLKIATYNIGGDKNLIMARKHWPLSMRQFQKERPRGDILMEEFPEGTANPNTLINIAYLLETEDADAVVLPYVDLLWAAHGWPAPLKLRNNITPILEALEGYESIKVSNYDYYSTIRLSSKSSKGATKEIVKKIGAPLVSLPIFTEGWYGYEHNKNSKWRWSSGNSELLILSYDTGPIEVEVSFSIQSISERELRITGPSEELLFHSDNLRETVHVKIPRLVLKPGVNSLTFNTSTPPPEHPSDSRKLAFRVIDFSTYEVERSPLNTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHL0</accession>
    <name>A0A139SHL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-L-glycero-D-manno-heptose-6-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ADP-L-glycero-beta-D-manno-heptose-6-epimerase</fullName>
            <shortName evidence="3">ADP-glyceromanno-heptose 6-epimerase</shortName>
            <shortName evidence="3">ADP-hep 6-epimerase</shortName>
            <shortName evidence="3">AGME</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hldD</name>
        <name evidence="5" type="ORF">AXK12_08320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose</text>
            <dbReference type="Rhea" id="RHEA:17577"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61506"/>
            <dbReference type="EC" id="5.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
        <text evidence="3">Binds 1 NADP(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.20" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713318.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08320"/>
    <dbReference type="EnsemblBacteria" id="KXU34023">
        <property type="protein sequence ID" value="KXU34023"/>
        <property type="gene ID" value="AXK12_08320"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008712">
        <property type="term" value="F:ADP-glyceromanno-heptose 6-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05248">
        <property type="entry name" value="ADP_GME_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01601">
        <property type="entry name" value="Heptose_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011912">
        <property type="entry name" value="Heptose_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02197">
        <property type="entry name" value="heptose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="352" mass="39182" checksum="38813242BE293981" modified="2016-05-11" version="1">MHTASLPAARTAPPFSGRILVTGGAGFIGSALIWELNQRGLTNILVSDILGSDEKWRNLTPLRFADYVEAPAFRAQLAEHPESFGKFSAIFHLGACSATTERDASYLIDNNYTYTKELARWALAHKTRFVYASSAATYGDGTRGMDDRSDELPALRPLNMYGYSKHLFDLHAQREGWLQSIVGLKYFNVFGPNEDHKADMRSLVNKAYQQIEQSGSVGLFKSYRPDYADGEQQRDFLYVKDAVAMTLFLAEGRLGDAPVPNSDRPSGLFNLGSGEANTWLTLTRAIFAALGREPQINFIDMPESLRGKYQYHTRADIGKLRDAGYSAPVTPLADSVRDYVQNYLRPAKKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHL9</accession>
    <name>A0A139SHL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_08375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08375"/>
    <dbReference type="EnsemblBacteria" id="KXU34047">
        <property type="protein sequence ID" value="KXU34047"/>
        <property type="gene ID" value="AXK12_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="215" mass="23410" checksum="FC3FBE9417640AF4" modified="2016-05-11" version="1">MHRYLGQGEGRVHVLKGVSFEARRGQVYAIVGPSGCGKSTLLYLLGLLDRQDAGDIVINGQAMSQSSDAARTAARCEHIGFVFQFHFLMPEFSALDNVMMPMRKLGRLTAPEMEARALELLGEVGLRQKAHRLGTQLSGGEQQRVAIARALANQPSIILADEPTGNLDVKNSAMIFDLLTRLAKDNGQAVILVTHNPEIADACDTVRPMRDGLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM0</accession>
    <name>A0A139SHM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713229.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08050"/>
    <dbReference type="EnsemblBacteria" id="KXU33980">
        <property type="protein sequence ID" value="KXU33980"/>
        <property type="gene ID" value="AXK12_08050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="351" mass="38198" checksum="80A2AA90BE8F5243" modified="2016-05-11" version="1">MILPKASCLTPTQLDEVTRIVSEFDCQIQPIAGALRTIYAIVGDERHELMMNRIEGLNYIDRIDRIQSPFKLMDRRCDLSRGRLKIGQVMLGEELLVIAGPCTIDPNNPNYFYETAAAVKEAGAQAIRGGVWKPRTNPYSFQGSNRSLDILMEGARRTGLPVDTEVMDEAQLALALDAGVTILQVGARNALNYSLLRAIGQAIADKPEVSVLLKRSLHMGPINEFISAAEYIAAFGNPNIMLCPRGTTPTLDGYRNHPDESVTPLLKEKTWAAVVVDPSHSVGKAVYVPSASLAAVAYGADGLCIESHVEPQKGIGDDPKQSVTPEELRALIVRARGLWDSMHDAPKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHQ3</accession>
    <name>A0A139SHQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08240"/>
    <dbReference type="EnsemblBacteria" id="KXU34010">
        <property type="protein sequence ID" value="KXU34010"/>
        <property type="gene ID" value="AXK12_08240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="48"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="36100" checksum="7C5304B44E7FCF7A" modified="2016-05-11" version="1">MAQIELRWPTPNRAWERGEPVRAFLQHAGSGNPISGGYGSVRNGGTRFHEGIDLFPVRRDARGEALDEVFAAMSGIVRYVNTEPARSSYGRYVVLEHDAQSPAIYTLYAHLASVDSALLPDVAGELVRVRAGQVLGRMGRSAGGYTIPKARAHLHFEMGLRLTDDFERWYDARGFDDPNYHGVFNGMNLMGFDPLAFYEAHRAAAIRTVADWFAQMEPAVVLHVASRATPDFVRRYPRLLKQGAVTLGAQAGWRIECDPSGIPFAWTPLSADAVRGLKLSPGEAAIVAVDEALLGTQPAKRLVMTSSTGVPIIGPDLDAVRQLLFGREDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ8</accession>
    <name>A0A139SHZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713195.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07825"/>
    <dbReference type="EnsemblBacteria" id="KXU34202">
        <property type="protein sequence ID" value="KXU34202"/>
        <property type="gene ID" value="AXK12_07825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="232"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="897" mass="99001" checksum="582961520D7B4B84" modified="2016-05-11" version="1">MNPLSLPIYELEEPLVAALRAASEASDAVGKPAGVRVLVQAPTGSGKSTQIPKILLKHGFADSAGNEASGPASGGQIVILQPRRLATRMLAKRVAAELGSALGETVGYQIRLESRTSAATRIRFVTEGVLLRQMLGDPELRGVSAILFDEFHERHLYGDITLARALQIQRSTRPDLRLIVMSATLDTATLEAYLAPCRVLTSAGRSFPVEIEYLPRPVNFDTEPVWELAAKYLEEALARRASDGGGSQPDGDVLIFMPGAYEIGRTVQAIGARRALRDFECFPLHGDLPAAEQDRALERSAGGAAPGARRKIIVSTNVAETSLTIEGVTLVIDSGLARVARYDPHRGINTLLVEKISIASADQRAGRAGRTAPGRCLRLWTQREHERRAPQEVPEVKRLDLAEVVLTLKASGIADVAGFPWIEPPNPAALMRAEQLLKDLGGVSREDSANAHSKITELGRRMLRFPLHPRYARMLIEAEKRGCVREVALMAALTQDRSFLLKNVPKSVEAERERRLGEAHTSDFLLLMRAWEAAAEARFDVEFCRALGIHAQAARQVGPVFQQFLNIAQREGLELETGPAAESELRKCVLAGFSDQVARRLDAGTLRCDLVHGRRGLLSRESVCQQAPLLVVAEITEVGGRGEVATLLGLATEIEEAWLEELFPGDYSVTTGVGYDEAAKRVVARHERRFRDLVLEAKVSGDEVPPSEAAALLAREVLAGRIALKHWDEAVEQWIIRVNRLAEWFPELESSPITEEDRATLIEQLCYGESSARAVREKPVMPVLREWLSAEQLAALDLYLPERLVMGNGQRSGRGGRARLRYLPEGPPILSARIQELYDVEGKFTLGQGRVPVRIEVLAPNQRPIQITDDLTSFWREQYPKIRAELSRRYPRHEWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI01</accession>
    <name>A0A139SI01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bipA</name>
        <name evidence="4" type="ORF">AXK12_07830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713148.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07830"/>
    <dbReference type="EnsemblBacteria" id="KXU34177">
        <property type="protein sequence ID" value="KXU34177"/>
        <property type="gene ID" value="AXK12_07830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="610" mass="67157" checksum="EA755349D8B78FA3" modified="2016-05-11" version="1">MNQNIRNIAIIAHVDHGKTTLVDKLLKEGGAWRAHQQVEERAMDSMDLEKEKGITIKAKNTSVHWQDKTINILDTPGHADFGGEVERALRMVDGVLLLVDAYDGPQAQTRFVLRKALQHGLKVIIVINKIDRENADPAGMYDKVLELLLELNADDEQFDAPVVYGSGRDGYMMYKLDDERRDMTPLFQTILDHVPPPFAKPADPFHMLVSNIDWSDYVGRIAVGKILGGSVKVGSPVYVLRHSEGGKRVQTKITKVFEFTGLGTTETDSASAGNIVGLAGFEDIDIGDTLTADEAGHALPFTQIDPPTLEMQFSVNDGPLVGTEGKLVTSRQLRDRLMRELKTNVSIYIEDAPDRAGTFNVKARGAMQVAVLVETMRREGYELLVSRPTVIEQRGDGGERLEPYETVWIEVPDTCVGAIMQNLANRKGQLTNMEKLNTTTMIEATITTRGLIGMEIDVVNATSGRGIMSHLFKNYGPYAGEVLTRITGTLIATEAGETTTYALVQCQERGKLFVSPGQKVYEGMIIGENPRNEDIAVNAVREKKLTNFRSQGEGVAAGLTPATQLSLERAIEYIAADELLEVTPSSLRLRKRILNNGERIKAAKAGRNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIG1</accession>
    <name>A0A139SIG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713051.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34326">
        <property type="protein sequence ID" value="KXU34326"/>
        <property type="gene ID" value="AXK12_07575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="224" mass="24230" checksum="268888F65CE717EA" modified="2016-05-11" version="1">MPSNEQAPGSLLGSLEQDYTQQAQASAAKETAALHEILKETLPETTPVYARSIFTSLLLLLVGGLLLSIGLGVFQVALHNGSFSSGEITVVIISLGLGGLMLYGSYKIIRYWKTPLFTLSLAGVQFRGCETLTPWAQVDNYLVNVTTYYGFITIAAQVSFDLTPGKPFEWPAKKPHGLKYKPKKNQVFAAAVGLSPSSKKVANLIGQYRAQSYALDRLAELGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SII5</accession>
    <name>A0A139SII5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="10" type="ORF">AXK12_07675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07675"/>
    <dbReference type="EnsemblBacteria" id="KXU34343">
        <property type="protein sequence ID" value="KXU34343"/>
        <property type="gene ID" value="AXK12_07675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="343" mass="36616" checksum="3634B918109E9536" modified="2016-05-11" version="1">MQENFRLGAPRLHAIFSEYTMMPLCLHAPAKLNLFLAITGRRSDGFHSLVSLAVPLDFGDELELRITDRETGDTRLRVEGEASAAEVPSGPDNLVLRAASAFREASGFARPVEFVLKKRVPVGAGLGGGSSDAVAALRGLNTLAAKDECALDEKTLCALAAKLGADCAFFACGKPAIMRGRGERIEPLNEAAAKRLGGGSLFVCKPAFGVSTAWAYGEMATRAASVEGGDYYVAEAEAERLCGQWLTSGVGAEQPLESLTFNNMESVVFRKYPALPVLAATFRERFGLILRMSGSGSACFAFLPKETRDAAANTALVRQLSECVRELWGPSAFSRVVRVRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIJ5</accession>
    <name>A0A139SIJ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712998.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07425"/>
    <dbReference type="EnsemblBacteria" id="KXU34300">
        <property type="protein sequence ID" value="KXU34300"/>
        <property type="gene ID" value="AXK12_07425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299216" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="774" mass="84138" checksum="3BA66A23319371A2" modified="2016-05-11" version="1">MSYSKLLGRALPGLSLAMGLSSFSYAQLAPSDTSDDQVDEDTVVLSPFEVSSAATGRYQANDVVSGGRISTNVLDAPGSITVLTSDFIKDIGGGRVLDVAKYVAGVTESTIPNAQDRAYIRGFQGASALVDGFMTASDANYDYVAIERMEVTKGPDAVLQPAGIPGGSINLVTKKPQWDFGGSLKLKLGEYDANRIEADVTGPINSALAYRLVMAGQDSRSYMRNSFRDSLFINPSIAWRISPSTQLVLRYEHYDFKSSQLEGLSIDPTVGTDDEFRTFPGMPTDFNPEPGKEFASRVSRFNTGTMLLTSVITDRLSVRLSGRLQHIQGGASAFHYGFLDKDGNVTEGGSRNPFTGKWEGGVLWVNTSTDPANPNWVATPATQPTGSFRHAGNYSKSQVWYRDLQNDWAYVVDSDFAKSSTLIGFSYRYAHNNSQSGAESLPDFTIDDVPNGPIITKPYGGDSRGITTSYQTYATETLEFFKNRLILSGGIAHMSFSGSSQDKLSDPITDGPFPVPAGMTYPGSGSKATYNYGVVVKPTENISLYYGHTENAVPSGDHKETYKGEDPFTLGTQDDLGLKLRLFDGRLFATIAYYEITQENYAVADPRNSELPPPPLYYPDILLHREAKGWEFQVIGSITPQLSFIASYADTKNRDPNGIMLRGAAEDSASGFVRYEFGPGPLKGLSAGIGANWLSKRALDTATGLTPAGVPNQPSAYLPPRTLVDAYVAYEWGAWSARVDVTNLTDQLDFIPQGRNMIWPVNPRAFSGSVTWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ83</accession>
    <name>A0A139SJ83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">AXK12_07255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712844.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07255"/>
    <dbReference type="EnsemblBacteria" id="KXU34540">
        <property type="protein sequence ID" value="KXU34540"/>
        <property type="gene ID" value="AXK12_07255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="172"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="396"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="471"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="471"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="559" mass="60898" checksum="5053B7BFEE57D638" modified="2016-05-11" version="1">MIGYLSQNFPLIHAFAPRTDSPLRLVAPSRHHTQTRPSKPSDPNRIKNGVGKTLVRNRMTKSAPKLSDFLKPDEIQAHKGSLDCPISGLVMDSRRVVPGSVFFALPGRRSDGVQFIDEAISRGAVAIVAQKLPGLVPSKLTYVQVADPRVVLARVAQRYYGHPDRALSAIGVTGTNGKTTVTHLVKHLLDTPKQRVGLIGTIHYDLGARTVPSFRTTPESLDVYGMLAQMRDAGCAQVAMEVSSHGIDQHRVLGLGFEVGVFSNLTRDHLDYHDGLEDYFKVKARFFTGELGTAPKIAVINTDDAYGQRLTAMLPETVRLVTYGENPDAMIRAEAVELGFKTTRLRLVWPEGTCEVTSPLIGRYNVSNLLAAAAVAWSTGLDLRKCLARLASFKGVPGRMEQVEAGQAYSVLVDYAHTDDALRNALGMLRAITPGRLMVVFGCGGQRDRAKRPLMTAAVQEFADFAFATADNPRGEALTQIFKDMEAGVSDAARITWIDDRRRAISLALDACKAGDCLLVAGKGHESYQEFADTVIPFDDRKTVRELIAIKALKHGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ2</accession>
    <name>A0A139SJQ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">AXK12_06960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712756.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06960"/>
    <dbReference type="EnsemblBacteria" id="KXU34771">
        <property type="protein sequence ID" value="KXU34771"/>
        <property type="gene ID" value="AXK12_06960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="158" mass="18599" checksum="62B79D222D5FC352" modified="2016-05-11" version="1">MSKARKSQRHNEVRNAKALRDYFVDERFEAGIALRGTEVKSIRAGRAQINDAFARYERGELWLYNAHIEQYAFGNINNHDARRLRKLLLHRHQVRKIVQELETGGRALIPLRLYFKEALVKVELGLCTGKKLFDKREALKKKVVDREIDKEMKARRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJS1</accession>
    <name>A0A139SJS1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">AXK12_06795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712676.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06795"/>
    <dbReference type="EnsemblBacteria" id="KXU34791">
        <property type="protein sequence ID" value="KXU34791"/>
        <property type="gene ID" value="AXK12_06795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="210" mass="24142" checksum="8E9608F35C42C02D" modified="2016-05-11" version="1">MGQKTNPVGFRLAVRRNWQSRWYAGKKDFSRLLVEDQLIRDKLMEKLKQASVPRIFIERASNRVRVEIYTARPGIVIGRKGQEVEKIKEELARLTGKEILLDIQEVKKPEIEAQLVAENVALQLERRIAFRRAMKKAVEVAMTLGAQGIRIQCSGRLGGADIARREWQRKGRVPLHSLRENIDYGFAEAQTVYGKIGIKCWICKKESDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJT6</accession>
    <name>A0A139SJT6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">AXK12_06775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712668.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06775"/>
    <dbReference type="EnsemblBacteria" id="KXU34787">
        <property type="protein sequence ID" value="KXU34787"/>
        <property type="gene ID" value="AXK12_06775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="93" mass="10482" checksum="3C81EB822C57EB50" modified="2016-05-11" version="1">MNANAVLKLARMTEKSSKQSAELGQYTFEVYPDTTKHSIAEAVEKAFGVTVRRVNIQNYRGKNKRTRAGRYVQGSDYKKAIVTLKTGDKIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJU6</accession>
    <name>A0A139SJU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34760">
        <property type="protein sequence ID" value="KXU34760"/>
        <property type="gene ID" value="AXK12_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026405">
        <property type="entry name" value="Chlam/Ver/Plancto_rRNA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04137">
        <property type="entry name" value="Chlam_Ver_rRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="80" mass="9050" checksum="E0B459E4C81333FF" modified="2016-05-11" version="1">MGAAAVLTPPLFLQNARAFQRIHSTPFTVMSQHNSLQGPRGIVVKRNVLKRFERVELLRKRGQWKAGDRVQGLKKTTPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ4</accession>
    <name>A0A139SJZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06320"/>
    <dbReference type="EnsemblBacteria" id="KXU34853">
        <property type="protein sequence ID" value="KXU34853"/>
        <property type="gene ID" value="AXK12_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="202" mass="22484" checksum="F74C017A946BB736" modified="2016-05-11" version="1">MPAAAVAPNRAVPFRHAGAGRPALHFADSKKIRELSQTHPLASPPIMLRRIAPLFLFALAALAPLPLHAQREKLPPEDLEWVEQNFPNAEISNTGIRYVVIEQGDGPTAKRGQMVSMLYIGRFINGDTFDQNLDPQKPFKFRLGRGQVIQGWDQIIPLMRPGDKWLVIIPPELAYGTRGQSPRIPPNTTLVFTMQLLAADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ5</accession>
    <name>A0A139SJZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">AXK12_06865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712702.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06865"/>
    <dbReference type="EnsemblBacteria" id="KXU34804">
        <property type="protein sequence ID" value="KXU34804"/>
        <property type="gene ID" value="AXK12_06865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="261" mass="28031" checksum="5AD6AF41C5EC1494" modified="2016-05-11" version="1">MSVVKNRDQIARIRAACAVAAKVLYELKQLVRPGLTTQDLDEAGRDLIAANGARSADYGYQIGNRRYPAHTCISVNEEVVHGVPSLRRVIQDGDIVSIDVTVNYQGYIGDNAVTIPVGDIPPEWAKLISVTEQSLALGIAQARVGNRIGDISHAVQTYVESHGYGVVRDYVGHGLGERMHEPPEIPNFGKPGRGPVIKPGMTIAIEPMVNLGHYNTKVLSDGWTVVTADGSPSAHFEHTILTTDKGPEILTVPPTLSSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK03</accession>
    <name>A0A139SK03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712594.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06625"/>
    <dbReference type="EnsemblBacteria" id="KXU34902">
        <property type="protein sequence ID" value="KXU34902"/>
        <property type="gene ID" value="AXK12_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115112" checksum="062E8EDA48CFE3D8" modified="2016-05-11" version="1">MILSDLSIRRPVICLVASILIIIIGLLSFADLPVREYPSIDSPIVSVDTSYRGASAEVVETKVTEPLEKEIASIEGIRLIRSTSAEERSQISVEFNLSRNIDEAANDVRDRVSRAQGRLPPEIENVRVTKTEADASPIMSLSFNSDRHNRSELYEIVERIAIQRLQTVPGVGSVDIRGPRYAMRLWVDADRLAAYNLTVSDVERALRQQNVEIPGGRIESVAREFPIKVQGNMANPLDYENLVLATAGNYQVKFTDVGRVELGREDYRGESFFKGRPTVGVSVVRQAQANLLDVANGIKALIPIIQNEMPEGVQVEVGYDTSVFVDRSVKEVYKTLWEASVLVVLMIFIFLRDWRATLIPLLAIPISIVGSFAVMSWMGFSINVLTLLALVLAVGLVVDDAIVMLENIYRRMEEGEAPVPAAIFGARQVAFAIIATTLTLAAVFLPVAFQKGQTGRLFFEFGITLAVSVMVSAFVSLTLTPMLCSRILHIKREGGEIRHNWLYRKTEPFFEGLVRFYSRCLGAAFRQKWIVLGATAALTLGGFWLYGGLQRELTPLEDRGSFRVNFIPPVGSTPHYMQAYSYEIEQELLKIPEMDRTFHRTGSGGRAFMFATLKLWEDRERTTQDVSREFSARLREVSTGGQAFVSPSRPLGGRRGGSDIEFVLQGSDFAELQRLGEKFVAILRADARFSQPRIDPSPTKPQLEVRIDRARAADLGVPVADIASTLETLLGSRRVTQFQRGNQQYDVVVQIEDADRSSPSDLTRLYVRSASGQLVQLGSLVQIDENAVPENYPHFNRLRSVTVGAQLGPDVTVGDAVSFLSAQAADILPSGYTYAWDGEAREYAESSSDTYMLFGLALLFTFLILAAQFESWIHPLTIYTGVAIALAGGLFVLYCTRFWGAPMTDNLFSRFGLIMLIGLVAKNGILIVEFANQLQVAGKTAFEAAFESATLRLRPILMTSIATILGAVPIAFASGAGAETRNPMGIVVVGGLAIATFLTLFVVPICYVLMDAQCQRFTGKSSAHGLQRADEIERETRKIEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK09</accession>
    <name>A0A139SK09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">AXK12_06440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712543.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06440"/>
    <dbReference type="EnsemblBacteria" id="KXU34873">
        <property type="protein sequence ID" value="KXU34873"/>
        <property type="gene ID" value="AXK12_06440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="307" mass="34205" checksum="46549F0CEB6776F5" modified="2016-05-11" version="1">MTTTQRKPAWLRAKLPSGPGYQAVRELVDTHKLHTVCQSAQCPNLGECWSRGTATVMILGNICTRSCNFCAIQTGRPTEYDLGEPARVADAVAKMGLRHCVITSVARDELKDGGASVWAATIRAIHYRMPQTAIEVLTPDWKGRLHDLDTVLDARPDIFNHNLETVERLQKPVRVQARYERSRSVLRHAKSRGFTTKTGIMLGLGETKEELEKTIYDIVEDGTDILTIGQYLQPTPQHLKVERWAHPDEFAYWKEFGLRAGIGVVESGAMVRSSYHADEQSEKYTGKAHLNTTNHLAETALAEAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK20</accession>
    <name>A0A139SK20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06730"/>
    <dbReference type="EnsemblBacteria" id="KXU34919">
        <property type="protein sequence ID" value="KXU34919"/>
        <property type="gene ID" value="AXK12_06730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="161" mass="17618" checksum="3A979350C217D880" modified="2016-05-11" version="1">MRTQTIGWPGFAAAFAYIDALFREASERRAQLFALKEGESQRQDLEGGAFAIAQVYAARPRYGVFESHRRYHDIQVVVAGEEQIEVAETALLTLTQAYDEERDVAFYADYAAGSVLRFKAGEVAVFAPCDGHMPSVRSDGFDTGSAGGGLVYKVVVKVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK28</accession>
    <name>A0A139SK28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureG</name>
        <name evidence="6" type="ORF">AXK12_06520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06520"/>
    <dbReference type="EnsemblBacteria" id="KXU34929">
        <property type="protein sequence ID" value="KXU34929"/>
        <property type="gene ID" value="AXK12_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="201" mass="21582" checksum="D3AF56EBABB99A38" modified="2016-05-11" version="1">MRIGIGGPVGSGKTALTLALCRVLRERYSIAVVTNDIYTAEDAQFLVRHQALPPERIIGVETGGCPHTAIREDASINLEAIDRLNRRFPGLEIIIVESGGDNLAATFSPELSDLTLYVIDVSAGDKIPRKGGPGITRSDLLVINKIDLAPLVGASLEVMECDAKKMRGERPFVFSNQKTGQGLDEIIAFIEAQGLLAQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK38</accession>
    <name>A0A139SK38_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">AXK12_06690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712621.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06690"/>
    <dbReference type="EnsemblBacteria" id="KXU34915">
        <property type="protein sequence ID" value="KXU34915"/>
        <property type="gene ID" value="AXK12_06690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29885" checksum="00E94CB74E049C4F" modified="2016-05-11" version="1">MKPLRKIAFVINKEKDGAAEVARELVAATRAAGVALKQTTRCPIPRGYLEGCDACCVVGGDGTLLGTAREAARWNVPLIGVNQGSLGFLTTFSADEALQLFPELLAGRFHVDHRAMLDCSTGPGVHDLALNDVLVKSEANSRIVRLEVLADGELVTTYNCDGLIFSTATGSTAYNLSAGGPIIHPDAGVIAMTPICPHTLSNRAIIFRQEVKLRVINRTEDCPLLVAMDGQLDLRVGMGSPIDICLSKLQVPLAHRDDYSHFAVVRTKLKWGGEVVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK41</accession>
    <name>A0A139SK41_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fusA</name>
        <name evidence="8" type="ORF">AXK12_06750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712636.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06750"/>
    <dbReference type="EnsemblBacteria" id="KXU34923">
        <property type="protein sequence ID" value="KXU34923"/>
        <property type="gene ID" value="AXK12_06750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="27"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="726" mass="79208" checksum="B66DC6D447654917" modified="2016-05-11" version="1">MSSSISIVTEKSKISAANAKDRPFPLEWTRNIGIAAHIDAGKTTTSERILFYSGAVHKIGEVHEGTAVTDWMEQERERGITITAAAISCAWDAASGPWKGIKQRINIIDTPGHVDFTAEVERSMRVLDGAVAVFCAVAGVQPQSETVWRQANKYNVPRIAFVNKMDRTGADFFRAIGEMREKLGANAHALYIPIGKEDDFNGVVDLVQNCAYIFGDEEDSLGLKPRTSAIPAELAAQAKEYREKLIEAASDFDDVIAEKYLGGEEVTVEELQVAIRKATISMNFVGVVPGSAFKRKGVQRLLDCVVNYLPNPLDIDEIKGVDSDGNEVAVKVDDNCKLAGLAFKLWSDPFIGKLVFYRVYTGKLPKGTPLYNPRTRRSERVSRLVLMRAMDRDEIDVAYSGDICALVGVKDVITGDTLCDEGYDVRLEPPSFPEPVISMSIEPNSKADQEKMSNALQRLVAEDPTLKVSTDEDTGQTILSGMGELHLDIIRDRMKREFKVEAASGKPQIAYRETILGNATGEGKFIRQSGGKGQYGHAVVKIEPNEKGKGIEVVNEIVGGVIPKEFIKPTTDGIMEGANNGVVAGYPVVDIIVRIVDGSFHDVDSSELAFKMAGIFAFKEAMKAANPILLEPIMSVEITTPEEYQGDLMGDVNRRRGQIQGMESKAGACIVAAHVPLEMLFGYVTDIRSLSKGRASASITPSHFEQVPNSILAKIVETSSRAPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK59</accession>
    <name>A0A139SK59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_06270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712479.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34969">
        <property type="protein sequence ID" value="KXU34969"/>
        <property type="gene ID" value="AXK12_06270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015344">
        <property type="term" value="F:siderophore uptake transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030149">
        <property type="entry name" value="FcuA/FatA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010105">
        <property type="entry name" value="TonB_sidphr_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552:SF82">
        <property type="entry name" value="PTHR32552:SF82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01783">
        <property type="entry name" value="TonB-siderophor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0798">TonB box</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="301"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="756" mass="81466" checksum="3CC2F5F40A098A82" modified="2016-05-11" version="1">MKTRLGLFSDLCDVRGLLARFFVAPASALALLLAGLVAASFPAQAQSRAAARAYSGDFSDLADSDFTTLPEMTVSDSRTALDEAAAALGGGQVARGARMGLLGTTDVMDTPFSVTSYTDEAIRDMQAQSMADLLAADPSVRATGGRAWMSESMSIRGFSVGAADTAFNGMFGVAPAGRVFLESVERSEVIKGPSAALFGMSPGGSIGGVVNLVPKRAHNEPITRLNIGLRQDSVRSTHADIGRRFGPGGAFGLRTNAVYLAGDTAMYDQSMHRRAGAIGADFRGQKLSVSLDLLWSHEDVNNATRPFNVGSALKVIPPAPSGRNAYPGSGEFETENGSGLLKAEYEINSDLSVYAGYGQHVYTTDGALIYPTMETTDGDYTWVYRQWKQRDDRESMEAGLRGAFEHPGVKHRYGFSVSFLHRDSGTFVPNRGSGRSNIWNPVAPPKLPRLPNRITPGSELELTSFALADQVEVFNGQLLLTLGVRRQEVDSLSLTSTNPLTRHYNKKATSPVFGLVYKPVHWASLYVSYVEGLSTGGTAPNDPVYINANEQLAPYVSEQYEAGAKFSLGGNWMATVAAYELTRPTAGAQFLPGPIPPGEPDRIYGIYGDQRARGIEINVSGQVVEGLRLLGGVALAEPKIHKSPNPDVVGKRLTGTAKVNANFGADWDVPFITGLALSARFIYTDSAYADEANQVVLPSWRRVDAGARYRFQDSRGIAYTLRLNIDNLSDARYWNQSARFSLAQPRAWALSLETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK80</accession>
    <name>A0A139SK80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_06250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712471.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06250"/>
    <dbReference type="EnsemblBacteria" id="KXU34965">
        <property type="protein sequence ID" value="KXU34965"/>
        <property type="gene ID" value="AXK12_06250"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="110"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29224" checksum="9259CBC3B961B560" modified="2016-05-11" version="1">MLLTPRTEHLIDLALEEDAALGDLTSRAIFAPTQRSRALIKAKEPLVLCGVEIAARTFTRLDPCFQIEPAAADGDSLAAGAPVLHISGPTLALLTAERTALNFLQRLSGIATQARRYAAAVEGTGVRIVDTRKTTPAWRALEKYAVRCGGAHNHRATLGEHVLIKDNHIAAAGSLTRAVALCRDAAPHGARIEVEAATLDQVQEALRAAADIILLDNMSPEQIAAAVAVIGGAALVEVSGGVTYQTLRDYALPGVDLISIGALTHSATAADLSLDIVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK86</accession>
    <name>A0A139SK86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712469.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06240"/>
    <dbReference type="EnsemblBacteria" id="KXU34963">
        <property type="protein sequence ID" value="KXU34963"/>
        <property type="gene ID" value="AXK12_06240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="450" mass="51318" checksum="D015F2E9304C0F4C" modified="2016-05-11" version="1">MKLPLAPPSWPAFVSKTPASRIAELYSAPELRSYWRDNDRYLHWDEFRHRPMPEGFSAEECWFIAKSIRHATYREVPLKDKYGRAFVFGMPSQLTELLQQIDRGLGFAGGLAAASTPSAERDNYALNTLIEESITSSQLEGAATTRVIAKEMLRANRPPRDLGERMILNNYLTMQRIRELKDQPLSIELVLELHRQITQDTLDKPEAAGRLRRSDEQIRVGDFSGAVDYHIPPPTEELPERLRALCDFANVAPDANSGTRFIHPVLRGIILHFALAYIHPFYDGNGRTARALFYWFMLRADYPLFEIISISHALLRAPTRYARAFLYTETDDNDLTYFILHQAAVIREAAKALHAYHQRKQRERRAASSYLNKVPGLNYRQQALLAHALREPGTVYQITAHARSHGVTHQTARDDLFALAERGLLTVSKLGRSYAFRTEASLAEKLSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA5</accession>
    <name>A0A139SKA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712619.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34914">
        <property type="protein sequence ID" value="KXU34914"/>
        <property type="gene ID" value="AXK12_06685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299316" evidence="1">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="157" mass="16442" checksum="37DDC6EB5A3DFFE1" modified="2016-05-11" version="1">MQITPHSRRLLFSLAAALFALVISGCSTPAGRITKNQDAFDSWPVEVREKIRAGEVDLGFTPAQVLVALGKPTRSYSHKSEGSEAEIWAYSGKSGKWPVGLSVGLGVGRSSGGWGRGTSTGGAIGINTGNYGHAAVDEALRVIFENGVVVAVEARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE9</accession>
    <name>A0A139SKE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34967">
        <property type="protein sequence ID" value="KXU34967"/>
        <property type="gene ID" value="AXK12_06260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="673" mass="71241" checksum="53E0EBE1907E0862" modified="2016-05-11" version="1">MLLVWRGFMRSLLLAVLFGGLTLFGGAGSWLHGQIILNNDSVLLLTEDFTGGLGTGPGEVTWAGSGGFAAVGGDRSVRIGDSTAIIDWDAPNFIGSGRTLILGDPNADGTLIWDNAINLGFTNRSIRVVHGTGNTTRADARFDRALRGNFLTIEGNGRLDITANNPNLRQAILIYGAELRLNDKGKFGGLRSIQIYNGGTLTLDNAGTSDSATGGQYSADRLLDNGSIRLEAGSFRYIGQTEAGDSVERLALIDLYLGSSTIDIINNRLGFVTEVRVGRLRQMSPGATLNFISSSGVSRFGDGATLRVEQALADFGGILPYATVSGEDWASLGLANSDGRPIVAYFGYNTGAQDSWGPTTNASPIADQVLSGSRNINSLRLTDGRQVDLSGRTLLVSASALLSVGAADTTIHSGTLNLLNQAYVHVYNTGASGLTISSRIIGRGLTKTGPGHLTLSGAVSNQIIGSIYVNEGLLILNKSAGVAAIHQASAGRIEIGDRRHSATLRLDKSEQISNSMNVWLRGGFADTARYVGQEVEGVLHFNGAGGAGLTETFRELVVLGRGVVDFQGGTLASPNWLILDDLKVFHSEGSSVLLVRNWVDLEDRLLVRRSGGDLAASLPYIHFEGYAPGAITRDYDAQFWEVVPAPEASTCGAVFGAVGLGLWARRRRQLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKK2</accession>
    <name>A0A139SKK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712384.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35034">
        <property type="protein sequence ID" value="KXU35034"/>
        <property type="gene ID" value="AXK12_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="19140" checksum="EF635EDF424EF269" modified="2016-05-11" version="1">MKFKTLFFPALAMGAIVLLSNILVQFTINDWLTWGAFSYPVAYLVTDVCNRILGPSAARRIVLVGFVVGLASSTVLASLQITLASGSAFLVSQLLDVSVFNRLRQRSWWQAPFIGSCLASVIDTAIFFKIAFANSELNWLSLAAGDLSVKLIMAALLLPAYRAVIRKSGLLPAPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKL0</accession>
    <name>A0A139SKL0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35044">
        <property type="protein sequence ID" value="KXU35044"/>
        <property type="gene ID" value="AXK12_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="413" mass="45471" checksum="4297CF0254A6C716" modified="2016-05-11" version="1">MDAAPSKILIVTTGHLSRNPRVLKEATTLGEAGYRVTVLGIRNRRDAADTDLSLTAKAPFLHTWVDMLGEHESFTSRFKATLRRGRQRLARELVSRFGLQSAEALGPSAAVLAAARRIPADLTIVHNEAAHWVGLKLLAEGRRVAADIEDWHSEDLLPSDRAARPTVLLRRNEKALLHQACYVTTTSEALAEGLFSRYGGQRPEVITNSFPLPALPHHREQNRGAAPSFFWFSQTIGPGRGLEAFLAAYARTTQLSRLTLLGQVCDDYRRHLLSLLPEPLRNRVSFRPLVSPEELPNVISQHDIGLALEESTPLSRDLTITNKILQYLGSGLAVIATATKGQCEVLSKEPLAGILLDNLDDPKTTAAALDTLLGSPDEFLARQQAAYQLAKTHYCWEQEAPRLLELVAGALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKU9</accession>
    <name>A0A139SKU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712130.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05660"/>
    <dbReference type="EnsemblBacteria" id="KXU35191">
        <property type="protein sequence ID" value="KXU35191"/>
        <property type="gene ID" value="AXK12_05660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="27182" checksum="4647293153B8ED88" modified="2016-05-11" version="1">MLHNVLSIAGSDPSGGAGIQADLKTFSARGVYGMAAITALTAQNTQGVSAIHLPPAAFVRQQIDMIFADVRVDAVKIGMIASSEIAQAVAAALAPHRQIPLVLDPVMIAKGGATLLDPTAVATLIEALLPLAHVITPNLPEAAALLGQPVAANRDEMAAQACQLLKSGARAVLLKGGHLEGENSPDLLAQGANLTWFEGRRIATLNTHGTGCTLSSALAAELAKGKPLQQATRAAKDWLTGAIAAAGQLSVGSGHGPVHHFHQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW4</accession>
    <name>A0A139SKW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712119.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35185">
        <property type="protein sequence ID" value="KXU35185"/>
        <property type="gene ID" value="AXK12_05620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="68" mass="7501" checksum="C002E02FECC76C50" modified="2016-05-11" version="1">MTPTPILRALDEPVSPELAMLLSLDARLARIEQRVNAVVPPQRPLRINEFAKLVGLSRYAGLDSDPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY0</accession>
    <name>A0A139SKY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712204.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05830"/>
    <dbReference type="EnsemblBacteria" id="KXU35221">
        <property type="protein sequence ID" value="KXU35221"/>
        <property type="gene ID" value="AXK12_05830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="20020" checksum="481CF86597F3D0B2" modified="2016-05-11" version="1">MRNLLVPVLLGLSLLAIAIVVRTGIFARSNPGRPINSAMRQALEGTGQLELSAEDTLLVDTQFPGKHTQKSGLMYVPRAAGKGPTPNIGDEVLVHYEGRLLDGSVFDSSRKRADASASEPLHFRVGLGQVIKGWDEALLNMRVGDKRTLIIPHWLGYGIQGRPPRIPPRATLVFDVELLEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ9</accession>
    <name>A0A139SKZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35229">
        <property type="protein sequence ID" value="KXU35229"/>
        <property type="gene ID" value="AXK12_05885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="86" mass="9845" checksum="2C639473EBD47BD0" modified="2016-05-11" version="1">MQRHTLLNGDGDPIPRPECATLALPRDERRRRASHLHINQSLRAERLHQLHATRHRTARSHSLPALRAHLWQHAQGLGPNPQRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL14</accession>
    <name>A0A139SL14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712267.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06005"/>
    <dbReference type="EnsemblBacteria" id="KXU35251">
        <property type="protein sequence ID" value="KXU35251"/>
        <property type="gene ID" value="AXK12_06005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="380" mass="41904" checksum="918179840818E1D6" modified="2016-05-11" version="1">MRDRLPNILWIVTTQWRGQACGFAGDVNARTPYLDALAAQSVDYTQAVTPHPFGPFARAALLTGVPSPENGVGTYYDPLPSDARTIAHELGECGYHTAFFGKWHLAGRDPNEPLVGEAHARMLVPPESRGGFAFWEGFESGFLLNDPWLHGTGLPESQQFAGYQSEVLCRRAAAYLGESYAHRPYAPWFAVVSLEAPHPPYAVAANGFEPLRPEQVELAPNVPRGGAVEARARRELAGYYAHITATDAAIGRLIASLPDGGADTVIVFASVHGDMHGAHGLFRKGWPHEESVRVPLLVRHPREAARRDETMAVSLLDLPAMVRAWSRGELWEERPVTAQISMPCVVDLPEQCDRVWRGWRSAREKRVYNADGSLWPLGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL23</accession>
    <name>A0A139SL23_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712236.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05925"/>
    <dbReference type="EnsemblBacteria" id="KXU35235">
        <property type="protein sequence ID" value="KXU35235"/>
        <property type="gene ID" value="AXK12_05925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="214" mass="23785" checksum="15B69BFF9D1900F4" modified="2016-05-11" version="1">MAVSPPSDLFTDECGHVRCYWCHASPLYRDYHDSEWGFPVSDDRRLFEKLCLEGFQAGLSWLTILNKREAFRAAMANFEAEELARFTAVDVEHLLGNAGIVRHRGKIESAINNARRVLALRQEYGSFAHYIWSYAPQAAQGRPPRLTGAALRTLTTSAASTALSKDLKKRGFSFVGPTTLYAFMQAMGLVNDHIEGCDTRAAAEAARARFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL32</accession>
    <name>A0A139SL32_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35245">
        <property type="protein sequence ID" value="KXU35245"/>
        <property type="gene ID" value="AXK12_05975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="571" mass="59869" checksum="BFEC8B4A32206A43" modified="2016-05-11" version="1">MAATATALVGAGLGILAWLLPVNLKSLSPAQLAAAGRGTTALEVLGERFIHTEKLGPAMLVLAAARDLGAPAAESLADQAAALAAAQPALVPWGGWAPALEPILGLGPSLTLSSAEEAGDGEDAAIKTTPVLQLLISESARAALRASLASSRSVGVQTVLATREVAQTGRFVPAHQPGGQPLDAVILLSALLYQSEQFSPELRRELRELAAVANEQDGLGHLEEFYIDLLSLAQRLDWVQLAELVSRSGGSTTLGEYAHLARIAPSELPIIYTAAFFAGSADRVASYLIRYGKVGSEDLRLALGLGGGAVQQLVLRQVPIKHATTPALSELADFSIRHPDFTLALKYFGYLAAAFLIFRGVERGLLAPFLGRGAVETDGRKSLVQSGLLAVFAAGLLILATEPYLLAATESLSEYRFRISIPLLANIAMPVADSAEASASTTPSMNTSTVVSIAVFALLQVAIYFVCLRKIAEIRAQTLAPLLKLRLVENEDNLFDSGLYVGMMGTATALVLQVLGVIDHNLLAAYASNLFGLVCVALVKIRHVRGFKNALIIEAETAAARAVPSPAPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL55</accession>
    <name>A0A139SL55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712279.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35257">
        <property type="protein sequence ID" value="KXU35257"/>
        <property type="gene ID" value="AXK12_06040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="101" mass="11461" checksum="07468753AE03A83C" modified="2016-05-11" version="1">MRYSDFKASLAAADSPPAALSAELRALWHDAKGDWEAAHKWVMHSESRAAAWVHAYLHRKEGDLANASYWYARALQPVVEAPLEEEWEQIARALCELVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL61</accession>
    <name>A0A139SL61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate/thiosulfate transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ORF">AXK12_06095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712298.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06095"/>
    <dbReference type="EnsemblBacteria" id="KXU35267">
        <property type="protein sequence ID" value="KXU35267"/>
        <property type="gene ID" value="AXK12_06095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="75"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="292" mass="31534" checksum="6F4727CF085A63E0" modified="2016-05-11" version="1">MAAPATRIRSVPAPTPTRPALSDPRWLRGLLLTLTLGFIALFLLLPLAVVFGEAFAAGVGAYFASFADPDAIAAIKLTFTAAAIAVPLNVVFGVATAWAVTKFEFRGKSLLITFIDLPFAISPVIAGLIYVLMFGLHGWIGPWLDAHDIQIIFAVPGIVLATIFVTVPFVARELIPLMQAQGTDEELAALTLGASGWQIFRRVTLPNIRWGLLYGVILCNARAMGEFGAVSVVSGHIRGMTNTMPLHVEILYNEYNLQAAFAVASLLTLLALLSLFLKSLVEWRHARSSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLA0</accession>
    <name>A0A139SLA0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712101.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05575"/>
    <dbReference type="EnsemblBacteria" id="KXU35317">
        <property type="protein sequence ID" value="KXU35317"/>
        <property type="gene ID" value="AXK12_05575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="195" mass="22134" checksum="94AF966A956141EE" modified="2016-05-11" version="1">MQRADFQSNPLLRVSVVGTDSTGKSTLAQYLGQHYGAPVALEFVRAFWDAHAGQIVAEDLPEIGRGQMAKEDRAAAEALHRRSPLLITDTELLTNVLYADLLFPGHCPDWEREEAERRSRRYALYLLCDTDVPFVPDPQRGSADPKRRAMMRRLFREMLTSRGLPFVDICGDWAERECRAVEAIDRLLESSDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLA1</accession>
    <name>A0A139SLA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05425"/>
    <dbReference type="EnsemblBacteria" id="KXU35323">
        <property type="protein sequence ID" value="KXU35323"/>
        <property type="gene ID" value="AXK12_05425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="3">
        <location>
            <begin position="265"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="516" mass="57796" checksum="4413DB75432FF698" modified="2016-05-11" version="1">METKGYALKEKVRALPDRPGVYLMKDRLGTILYVGKAKSLKKRVSSYFQRGRARSIEQPKIRSLIPLIHDFDIIEVRSEPEALLLEGRLIKQWKPRYNTDFTDDKRFLLVRVDLSQPLPRFALTRLRKDKHSRYFGPFPHSGPLRTTLAQMRRQFGILLADATPTLLPDGRYQLYDDVRQEIYGHENLVTPAAYRARVDAACAFLEGKSRETLKTLREQMQAAAESLEFEKAAQLRDLITALDATLERSRRFERHTPAQLLDPANASTPHSHGSAKASALAATAALAALARALDLPAPPEHMECFDISHISGTLVVASMVHFTHGRPDTDRYRRYRIKSFIGNDDFRAMEEVVARRYHRLANEGRPLPDLIVIDGGRGQIGAALKAFAAIEVKPPALIGLAKKHETILFADARAPLNLSLNDPALNLLQRLRDEAHRFANTYNADLRSRKIRESLLDDIPGLGAKRKAQLLAHFGSIDRLRAASPTALATLPGIGPKLAEKIHQTLRPAFPSPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLB7</accession>
    <name>A0A139SLB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06045"/>
    <dbReference type="EnsemblBacteria" id="KXU35284">
        <property type="protein sequence ID" value="KXU35284"/>
        <property type="gene ID" value="AXK12_06045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="268"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="487" mass="53214" checksum="24E3D128EED484DE" modified="2016-05-11" version="1">MRRAPARKAERPVSVAAVDLGATSGRVILGTWSGERLALCEAHRFSNTYRELGPHAYWDIGTLWHEVRSGLLKAAARLPSGTKLASLGVDTWGCDHVLLDDTGRLVFPLHAYRDNRVQPALRALNRDRDSSARLYEATGIPNIFYNTSLQLAETLTRYPAISQLATRCLFLPDYFNFLLSGRAENELTIASTSQLLDVSENANWSPAALAQFGIPQHWFRPPVVPGAILGPVRAIPELRGTQVIAVPGHDTACAYDAMPTDGEGDLFLSSGTWSLVGFESPRPLLGPAAQKARISNERAGNGHFRPLTNIDGLFLLEQLMAEFADRPRNDKDWAALVNATAAQSETPSESRLRLNDGSFASPPSMRTAIDAQLSKRKLSLPRSLVGYARLIWDSLGQGHADSMRLFESLTGERFKRILMVGGGSKNRLLCQATADAARIPVLSFSLEGTAVGNLARQLIALGAVKDLSHFRQTLAAQLKTTTYTPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE7</accession>
    <name>A0A139SLE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712088.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35310">
        <property type="protein sequence ID" value="KXU35310"/>
        <property type="gene ID" value="AXK12_05540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="187" mass="19192" checksum="8CBEDBFFD2C79CBB" modified="2016-05-11" version="1">MITRPLELSSRLRVAPRSFDALFWVNVGALVLFFGLFGSRFVLAPGLGVDFYLPELGGARGGAVRTMHVISMVGSGLIFTDDGALPLEQIEGWLAVQSSTGLSGEPLRGAQPSPVGASPNTGVPQSEGEVASPSSVQPVLLIRAGAGISVADLAAVTSAAQSYGFRVQIAALEPESSARRAGEGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF1</accession>
    <name>A0A139SLF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SufE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712096.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05560"/>
    <dbReference type="EnsemblBacteria" id="KXU35314">
        <property type="protein sequence ID" value="KXU35314"/>
        <property type="gene ID" value="AXK12_05560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="3">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="427" mass="46429" checksum="9B13B242C87AEBFE" modified="2016-05-11" version="1">MTERQRNLIDDLNLIENPQERLSILVDRARHLPPLPAETRSDKTLVPGCVSQVWLLCERDTAGRCYFRCDADSPLVKALVAFLCDYYNGCTPAEILAEIATEEAKVAALDERPAHGTEPRTRSPDKRAEDASPLAALGLLQTLSATRRNGLAQVRARIQAFAAASEANSQSTKPPRNLANHGSEHAPLLLYDAHTHSPALNGLATLSVLNGSQPADWPTVAARAAEHPDALIPSYGLHPWYCATAPNDWLAQIRTRLLTDPRAQIGEIGLDRALIRRSEAASIEAQLAALNAQLALAAELDRVATIHCVQAHGLLLDTLHNAPKLPRLLLHSYSGSAQMIRDFAALGAYFSFGASVLDPRRERLLNALRATPPERLLVETDTPAGLSYATNTLEQNHWALASLLGQPVEQLTARVAANFQRLFLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG6</accession>
    <name>A0A139SLG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_05360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712005.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05360"/>
    <dbReference type="EnsemblBacteria" id="KXU35398">
        <property type="protein sequence ID" value="KXU35398"/>
        <property type="gene ID" value="AXK12_05360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="484"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="501"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="867" mass="92874" checksum="37651BD1F1AB5F1D" modified="2016-05-11" version="1">MSKPPIPNSTRARSAAASSASPAFTQTPRYRPNWIAAATCFVAGLWLLVALLDYAPAQSSCATTDPIGANLAGRWGANTTWVLLYTLGASTWLVPLFLLWMLYVSLRNARHLAATRLTAIALCLLSLSGLAAMLQSISPSDYFPEGPGGWVGALLYTRALHGTLGPFGAALLLGTLYLGGLLFIFTKDVGAEINRYLAAFQIWRETAALRRAERAEARRLLKEDRAKEKAAAAEAKAELKAQIAALKKGSTKPKAAASSAIDSDEADSEQKARIADQVSAAVAAATKTSSAPETKGNDAPPALARGKKSALENGAAASSATNLDLKIVQAEEIKKVPVSIPQSDDADYRFPDIALLSEQVTDTPGNSREEHQQNAENLLRILGDFGVTVRLGEIHVGPVITRYEVEPGTGVRVEKIAGLDKNIALGMRAQSVRILAPIPGKAAVGVEVPNKHATPVGIREIIESEDWARVKAELPIALGKDVSGKPLISDLTKMPHLLIAGATGSGKSVCINAIVASILYSKSPRDVRLLMVDPKVVELKIFNTLPHMLIPVVTEPKKVPAALKWLLGEMEQRYQLFAKCNVRNILGFNNRKKDAPLDPVEAAARAQMEAIQNGNGADEAAEISVPREPSAEEQNREELPEKLPYIVAIVDELADLMMVAPAEIETSIARLAQLARAAGIHLIIATQRPSVNVITGVIKANLPSRIAFQVASQVDSRTILDTKGADNLIGRGDMLFSPPGSSRLVRAQGAFVSDDEVIAIVDALKVNGPPRYATSVQQQIDRAASDGDDDGESDYGDLGEDSELFAQALDVLRSTKRASTSMIQRRLRIGYNRAARIMDLMEDKGIIGPENGSSPRDILVDLDSYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH9</accession>
    <name>A0A139SLH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 4">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05400"/>
    <dbReference type="EnsemblBacteria" id="KXU35411">
        <property type="protein sequence ID" value="KXU35411"/>
        <property type="gene ID" value="AXK12_05400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="42451" checksum="E23A4538C9834B71" modified="2016-05-11" version="1">MAAPEQVYEVGERRFLLDPVKAQAALAGKRVINGVRSEQFGLFPLKYPWAYELYRTMKANHWEPEDIPMGKDIEQWRDPLAVTDVDRWIIRMGLGYFSAAEGIVGDNVQHVTRQLISAPELRLVTSRHAHEENIHADSLLYMIASLGINPHECEAMFDDIPTIVRKNEFVTRNSKDLRVGLDFTQPENIALYAKNMFLFGQCMEGTQFYGLFGMILSLYRQNKFPGVGQMFRYTLRDESNHIENYRNLFMDLVEENRVIWTPELREELREMMHEAVTLEKDFIRDCLPMNAVGLVAEDFLTYIDYIADRRLESCGLEPFSKTEIQNPLPWLAEMMDIKKEQNFFEGRVTEYQKASSLSFESDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLL6</accession>
    <name>A0A139SLL6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KDO-8-phosphate synthase</fullName>
            <shortName evidence="6">KDO 8-P synthase</shortName>
            <shortName evidence="6">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kdsA</name>
        <name evidence="8" type="ORF">AXK12_05165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the KdsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000041">
        <property type="protein sequence ID" value="KXU35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711939.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05165"/>
    <dbReference type="EnsemblBacteria" id="KXU35453">
        <property type="protein sequence ID" value="KXU35453"/>
        <property type="gene ID" value="AXK12_05165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="30860" checksum="6B48140D8441D2B3" modified="2016-05-11" version="1">MHRPALYDPAKLLLIAGPCSLESEAICRTVAEELVRLRETQPELNIVFKGSFDKANRTSISGPRGMGLEAGLELLALVKRDYGLPVLTDIHERAQAAPVAQVCDVLQIPAFLCRQTDLLLAAAETGRVVNVKKGQFLSPQEMAHVVAKIRDAAATGAKARASEIWQTERGTTFGYQNLVVDMRTFPILRQNGLPTIFDATHSVQLPGAGGGKSAGQREFVPPLARAAIAAGADGLFIETHPDPDRAPSDGPNMVYLHELAALIESCLAIWRGLAPFDLARGALAAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLM0</accession>
    <name>A0A139SLM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711976.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05280"/>
    <dbReference type="EnsemblBacteria" id="KXU35384">
        <property type="protein sequence ID" value="KXU35384"/>
        <property type="gene ID" value="AXK12_05280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="300" mass="32860" checksum="BD710BAF6FA02DDC" modified="2016-05-11" version="1">MRNTFINTLCDLAEENQDVFLLCGDLGYSVLEPFAEKFPERFLNVGVAEQNMIAVASGLSAEGYNVFCYSIGNFPTLRCIEQIRYDVCYHKANVKVVAVGAGYAYGALGVSHHTTEDIAMLRALPGMLLCSPADAIEARLAADFMVRRNGPGYVRINKSGEPNVHSCVPHEFLPGKVLWVKEGQEVLVLTTGAITHSICLELTRSHPDWALASVPFIGNYDSALLVDLAKRFNQIVTVEEHQLNGGFGSSLLEALGDLYSSGQLPHMPKLRRLAIPNSFIAKAGTQEYLRNLAGLTLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLN9</accession>
    <name>A0A139SLN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05375"/>
    <dbReference type="EnsemblBacteria" id="KXU35410">
        <property type="protein sequence ID" value="KXU35410"/>
        <property type="gene ID" value="AXK12_05375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="128"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="441" mass="47412" checksum="8EA42550A71A55F2" modified="2016-05-11" version="1">MLGQSGYPLPKPSAGLQAYARVAAIRVEVAPERAGWTYRVGEQVKFRVNVTADAQPLAGVTIRYQVGPEMLPAEEKSATTPTNAEPLLIEGGTLNEPGFIRCVVTLDVGGRSYRAVGTAGLSPGEILPTQTEPEDFDAFWAAAKAELAKVPMEARRTLLPERCTSTVDVYQVSLRDAGGRNSRIYGILCVPKGDGPFPAVLQVPGAGIRPYGGAIELAARGVITLEIGIHGIPVNLSNEVYDQLGAGALDWGSGGYPLIQLDSRENYYYRRVYLGCVRANDYLVSLPEFDGKNLLVMGGSQGGQLSIVTAALDPRVTALSAYYPAYCDVTGYLHGRAGGWPHMMRANEDGSPSLHATGPKLRTTSYYDVVNFARRLKVPGHYAWGYNDEICPPTSMYAAYNVITAPKQLLLALETGHVLPIPEQLAVEMAWIAAQLGLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS1</accession>
    <name>A0A139SLS1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05085"/>
    <dbReference type="EnsemblBacteria" id="KXU35497">
        <property type="protein sequence ID" value="KXU35497"/>
        <property type="gene ID" value="AXK12_05085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="104"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="350" mass="38999" checksum="5CB1DD67126F8E75" modified="2016-05-11" version="1">MRVIWRGARWPIGKSQVCFEPGAASAAIWFSLPAPKAALLTAPHMLYDRPYMRDSYPSARKTSALVWLIAAIISGFVLQLVFSRWFGIDRTFTQLFALSPAGFKSGQVWPLLSYSFLHAPENLLHIVGNLLGLYFLGRELLPVIGERRFVIFYAAASMIGGLLWLATHWIGGRNYGLLIGASASVYGLLTIFACFYPNRRITLLLFFVFPVSLKPKHIAWAALGLSACGFLFYEIMGAASPFGIAHSAHLGGMLSGWLYYRYLHERNWGRLELPKWARRRAAASKTTASTSKRATAAAAAPKYRVNLSEPTNLRAEVDRILDKINAQGFGALTDEEKRLLDTAKDHLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB2</accession>
    <name>A0A139SMB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_04945</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711855.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04945"/>
    <dbReference type="EnsemblBacteria" id="KXU35600">
        <property type="protein sequence ID" value="KXU35600"/>
        <property type="gene ID" value="AXK12_04945"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="12">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="13">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="377" mass="40477" checksum="1226BC1F4F829B38" modified="2016-05-11" version="1">MSDTLSYESSGVDYDQLDAFKRACQGAARTTAPLLAAHGYSEPANTRGESCYLIEAADHYLAHVEEGLGTKNLVADAVYAKQGLNFYREIAIDTVATIVNDLVTCGALPISVAMHAAVGDSAWFADSARMQALVDGWAEGCRQAHAVWGGGETPTLKSIVNESAIVLAGSAIGRIAPKSLRITGEVREGDRILFLASSGVQTNGLSLCRLIADQLPKGYATPLADFVPTAGSSEGQSYGEALLAPSVIYVNFVAECQRRGLPLNYVAHVTGHGWRKLMRLEEPFVYEITEPREPLPVFQFLEKAGPISRRELYATYNMGVGFAAYVAPEYTEAVLAAARETGYDAWLAGTVKKEGTRKAVEIPSLGLSYEADTLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN24</accession>
    <name>A0A139SN24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">AXK12_04070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711492.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04070"/>
    <dbReference type="EnsemblBacteria" id="KXU36013">
        <property type="protein sequence ID" value="KXU36013"/>
        <property type="gene ID" value="AXK12_04070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="598" mass="66210" checksum="96CCAE839982CE47" modified="2016-05-11" version="1">MEIAHTRNFCIIAHVDHGKTTLSDRLLEHTNTVAQRVLTDQHLDSMDLERERGITIKSHPVTMLYPSKNGTVYKLNLMDTPGHVDFSYEVSRSLAACEGALLLIDAAQGVEAQTVANAHLAFGQNLKVIPVINKIDLPGANLDLCLTQLEDILTIPAEEAILASGKAGIGIEEILEAVVERVPPPRWSDYAQTRALVFDSLYDSYRGVIAYVRVFSGEIKPGDSMLLMSSSTKSEVKELGIFTPKMEKAEKLAAGDVGYLVSNIKDTSEIKTGDTITLAQKPATEMLPGYQEVRPMVFCGLYPVESSDYEKLKAAMGRLRLNDAAFVFASESSVALGFGFRCGFLGLLHMEIIQERIRREHDVDIISTYPSVIYHVVTDDGELREVDNPVNLPDPAAVREIREPTIKAAIHIPNESMGDIFALIMEKRGSIDHTDTLDASRVMLTCTLPLNEILVDFNDRLKSITRGYGSMDYELGEYRSADLVKMEILINAEPVDAFASIVHREKAEGKGRELCGRLAEIIPPQMFKVAIQAAIGGKIIARDNVKEMRKDVTAKCYGGDISRKRKLLDKQKEGKKKMKQFGRVSIPSDAFIKVLKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN48</accession>
    <name>A0A139SN48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711558.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36043">
        <property type="protein sequence ID" value="KXU36043"/>
        <property type="gene ID" value="AXK12_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="212" mass="23590" checksum="BDD47AAC9CFE9E3C" modified="2016-05-11" version="1">MKLAFLGESPADEVALQILAEAVLGERVRRVLPNLRARGWPNVAQVLPPIIHHLHFNTDAVGLVVSVDADDSVVHTVEHEAAGYHHPQCRLCQLRAIFRRATKNLPPARGRQRVLRGVGLAVPTMEAWYLCGRDESVGEAAWLAGQERGQLPYTRVELKERVYGTSRPSLQLEIECARRELARHRGDMRRLEADFPGGFGALARDLKACLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN51</accession>
    <name>A0A139SN51_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_04660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711714.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04660"/>
    <dbReference type="EnsemblBacteria" id="KXU35977">
        <property type="protein sequence ID" value="KXU35977"/>
        <property type="gene ID" value="AXK12_04660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="42727" checksum="11F61FF5322834D5" modified="2016-05-11" version="1">MTFDLSGAPAALDETQPRRVLLPTELPPSLDFGGGHSFRPVHTLTGATMGTYWRARIVERATAHADDAAQANAILIKTFDEVVSRMSPWEPESDLACFARTPPGEWLSLAPETAHVLARALEVAALTDGAYSPALGEVTELLGFGPGDPAARHSIDSPAVRAARARADYRRLELDTARRTVRQRPSHGDCASTNSPLHIDLCSIAKGYAVDLASERLHAAGWHHHFIEIGGEARGRGCKPDGQPWWCYLETPTASDTEKTAQSEVPRSVAGLCELAVATSGNAHHHFEDEVSGKRIGHILRLDDFEERKTANERSHHTRIGSTHDALHSVTVFAPTCMEADAWATALYALGPERGLPLAEAQQLAARWLYLEQAPRPTLREAATTQFQRLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB0</accession>
    <name>A0A139SNB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711588.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04350"/>
    <dbReference type="EnsemblBacteria" id="KXU36057">
        <property type="protein sequence ID" value="KXU36057"/>
        <property type="gene ID" value="AXK12_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="6">
        <location>
            <begin position="63"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="706" mass="79548" checksum="8D56C2E8CAF93FE4" modified="2016-05-11" version="1">MAKRISKKTTDQAELEFSNSADAATGAEARPKEGAASPGLADLEDEGLNPVDAAPAQEPALRKHYRNWFLEYASYVILDRAVPHLDDGLKPVQRRVLHTLWDMDDGRFHKVANIVGTTMRLHPHGDASIGAALVAIAQRGWLIEPQGNFGNPFTADEAAAPRYIEARLTPFAREVLFNPKTTTWQLSYDGRAKEPVALPAKFPITLLEGAEGIAVGLATKILPHNFNDLCRAAINHLQGKAFRIYPDFPTGGIADFSEYNDGERGGKVRVRAKIETRSKTLLAITELPYGTNTVSLIESIVAANTKGKIKVKHVDDNTADKVELLVHLPPGSDPEQVTQQLYVFTQAQMNLSPSACVIVRDPETGADKPQFIGVREILRRSVDHTVELLRSELEIRLGELDQQWHWDSLERIFIEERIYRRIEKSKTWEEVLEEIREGLKPFIAGLRREVTEDDITRLTEIRIKRISAYNRFQADERIKKIEAEIEAVKHDLAHLIDYAIAWFERLQEKFGKGHKRRTTYDEIEQISAAEVASANQRLYVNREEGFIGLNWRQHEFVKECTILDSVLCLMADCSLKVSKVADKVFMGRNILHVGVWPKEGDGRFYTLIYQDEKTGRAFAKRFQIGGLSRDKLYSLAKTEGPARVVYLDVAESEAAMPKAVHIAIDGRSGARIRELDFDLTRVPLSTRSAKGLTVTKWTIKSVKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB2</accession>
    <name>A0A139SNB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_04390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04390"/>
    <dbReference type="EnsemblBacteria" id="KXU36065">
        <property type="protein sequence ID" value="KXU36065"/>
        <property type="gene ID" value="AXK12_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="455" mass="50732" checksum="1909A37072555E8A" modified="2016-05-11" version="1">MHRTVAKKFNAYPFAYHAEIELEISTLTNRGHGLGRVELPEEGAAPREGLDAGRADNAGTPDKEGPPDLEPTRSTPSKNSLRQWVVMVPFCLPGERVRVRVFRNHKNYSEADLLKVLRASPHRVEPYCALFGQCGGCQYQHLDYAEQLVWKRRQVEELLQHMVGIEHEVAPVIGSPRQYGYRSKITPHFKVGRPAIGFLRQGTRFEVIDVPECAIATPEINARLVEVRERTRQRLERREYKRDATLLLRHASEGVVTDYDAVITEELARGDAQEPLKLRFLARDFFQNNPFILPAFTGYVREQAASSGGRFLVDAYCGSGLFALSAASAFEQAAGVEISESSIRFAQENAVANGITNARFLAGDAAAIFAGLDFPPEETAVIIDPPRRGCDEGFLGQLFAFGPRAVVYVSCDPATQMRDLRLFLEAGYALKAVQPFDLFPQTRHLECVITLARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC2</accession>
    <name>A0A139SNC2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711592.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04360"/>
    <dbReference type="EnsemblBacteria" id="KXU36059">
        <property type="protein sequence ID" value="KXU36059"/>
        <property type="gene ID" value="AXK12_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="240" mass="24751" checksum="24477EC9EDE124BA" modified="2016-05-11" version="1">MKKFFLILLGGLVLLGAGLYYGLGPVLNSGVLIGVNNLGPKVTQTHVSLADARLSPFTGRGTLTGLVVGNPPNWTAPHAFTLGKIDLKVNLRSLRGDVIEIEEIVIEQPEFVYETRLVSSNLGDLLKAIEQFTGTSAPTPDATSEKPAKPVKLIVRKFRLVGAKASLGVGPAALPVSLPTIELQDLGLAKGGATPAELSGEVLSQVLGEIAKAAANPINAGAAAGKGVGGAVKGLKKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC5</accession>
    <name>A0A139SNC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04345"/>
    <dbReference type="EnsemblBacteria" id="KXU36056">
        <property type="protein sequence ID" value="KXU36056"/>
        <property type="gene ID" value="AXK12_04345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="422" mass="45111" checksum="97BA58FA264D46BD" modified="2016-05-11" version="1">MEILISAAKLDAVEPLCAAAESAHLLPTHCEPAALALWRAFSREVDAPSLFVDVGARSTQVIIGGGGAAPYLRTLNFGGNTVTRSLAQGLGCDFAEAEAAKRRASQLLENAKPSQESEALLREAVGQAASPFVQKLGAELLLAKLAYLRQSGVLSPTRVYLGGGGSVLLGLREEIAERLSLPVFELPTPASIEVAPSSVGRAPVGASDLYALYGLALGAALPEAQVLNLFPLGRRVAREVRARRRWGLAAAALLVLLPFLLLLQQRSAIAALHTRAAAVDARAAPLLRLGALNAQAQTEVDALRVRLAHLDALNAQRESWLGFFADLQARLIGVGDVWLERFHYNAPSTDQVDETGSPQAATIEIGGWLLESGRTDESLQRFFDSLQALDFVQGVVGERYDRKRPGVIRFDATILIAPEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF2</accession>
    <name>A0A139SNF2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase I</fullName>
            <ecNumber evidence="2">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711490.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04065"/>
    <dbReference type="EnsemblBacteria" id="KXU36012">
        <property type="protein sequence ID" value="KXU36012"/>
        <property type="gene ID" value="AXK12_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="285"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="440" mass="49828" checksum="FD47491A36C2F8AF" modified="2016-05-11" version="1">MFSLFASQKQKMRRSAKQWLELATKVYHYRRDRLSADELRSLQTHSAALRQLLRERGEPMKLKLAIDALESVLRQVSGTHYPKTSLVENVEFFLVAAIVILGFRAFFIQPFKIPTNSMWPSYYGMTIDNFETAEDAPSGAGRLWRLLSLGAQRREIVAPRSGELSADFFVSAGGNDLELAYTFKQGRSWFVLPTTVREYTFYVDGVPVRIQVPQDLQGVDKAMRDTLFGGDSGFAEHLRALQRDRTKIERHFLEVYPGVSRAAEVLRVPLGRNLAKGQAVLSFDILTGDQLLVDRMSYHFVRPQVGQGFVFRTGKIDSPLMKDRNGQQIAQYYIKRLTGLPGDTLEIKDYTLYRNGAPITGSVSFDKNAKREGDYVGYRNLQALSLGKTMTVPKDAYMALGDNSANSQDSRYWGYVPATEVVGRPILIYYPFTHRTGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF5</accession>
    <name>A0A139SNF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711646.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04515"/>
    <dbReference type="EnsemblBacteria" id="KXU36086">
        <property type="protein sequence ID" value="KXU36086"/>
        <property type="gene ID" value="AXK12_04515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="560" mass="61491" checksum="4970C056D886FD3F" modified="2016-05-11" version="1">MSVSQKNHYRPNFHFAPSDGWVNDPNGLFYLDGVWHLYFQYYPHAPEHGPMHWGHATSRDLVHWEEQPIALFPDASRSIFSGSIVVDAQNTAGFGAAEAERAEGAVPPVVAIYTAHDAAKAKSGGDAALAAETQAIAYSLDGGTRWTHYEANPVLPNPGLRDFRDPKVSWDAERGRWLMVIAAGDCVHFYTSPNLKDWAFLSEFGAQIGAHGGVWECPDFFSMKVEKVHGEPPPPDAEEKWVLLVSLNPGGPNGGSATQYFVGDFDGTKFTPDKQFTAPPNHKKNAAKQIVGKPLNNPTVLETICSPYAWLDWGRDNYASVLFNNVPDGRRVMIGWMSNWDYAKKLPTSAEGWLGQMTLPRQLILAKTSVSGYVIKSHLPSEFGGDLDPTRKIRRSGTLKANGPLAQVGIAPITTLIESGEIDLTRAIMRIKIRQMSPMGSYRLVFCNEQGERLEILQHNAVPGTPVIVNRHSAGEGDFSQNFAGPVIAAPIVPVEEQGLCCSETNFMIILDKTSAEIFCNGGERAITVLFFPNWPYTTLLYSSDVAGSSYAIEVEEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNK4</accession>
    <name>A0A139SNK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GBBH-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711634.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04480"/>
    <dbReference type="EnsemblBacteria" id="KXU36080">
        <property type="protein sequence ID" value="KXU36080"/>
        <property type="gene ID" value="AXK12_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="103" mass="11347" checksum="17902173D686A04A" modified="2016-05-11" version="1">MERPTNIQLIGKELGIVWSDGCETYYDPARLRAASPSAQAQGERDILGQVHGGEGPTTARDHSGVTIHGWQIVGNYAVRFEFSDGHRTGLYSFDFLRELAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP3</accession>
    <name>A0A139SNP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">htpG</name>
        <name evidence="7" type="ORF">AXK12_03915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711425.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03915"/>
    <dbReference type="EnsemblBacteria" id="KXU36207">
        <property type="protein sequence ID" value="KXU36207"/>
        <property type="gene ID" value="AXK12_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="31"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="617" mass="69349" checksum="8367C3A7FB13866C" modified="2016-05-11" version="1">MSNEAPAAQKFEFQAEVKQLLDIVIHSLYTEKEVFVRELVSNASDALEKLRHTQLTEKAIYDDALELEINVTTDDTAKTITIQDFGIGMTRDELVQNLGTIAHSGSKAFLKALSEGGAKNTNLIGQFGVGFYSVFMAAESVKVYSRSWRNDEPGHVWTSSGSGSYEIEPSEGERRGTKIVIQLKDDCADFAQDWRIKEILERYSAFVSFPINLNAKRINTIQALWLRNKNEIKDEEYTEFYKFQAHAYDEPRLRLHFSADAPLAINSLLFVPKENTEKLGFSRLDPSVSLYCRKVLIDAHPKDLLPEWLRFLKGVVDSEDLPLNISRETMQDKALIDKLGRVITKRFLKLLEDEAKNRADAYAEFYAEFGHFLKEGAAMDFAHKDQLTGLLRFESSLTEPGKLTSLADYVTRMGAEQKDIYYLVGPSRAAIESGPYLEGFRARNLEVLFCYESVDEYVMHNLREFDSKTLRAADHADVKLPDLPQPSEGALGKDETSALTTWLKDTLGTERVAEVTASDRLVDSPVLATSADKMMSPHMRRLMKAMKQDGADAPAKVNLEINPRHAVVKRLHTLHSSEPEKAKLVAEQLLDNALISAGLLDDANAMVTRLNKLLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNT7</accession>
    <name>A0A139SNT7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_03555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36226">
        <property type="protein sequence ID" value="KXU36226"/>
        <property type="gene ID" value="AXK12_03555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="4"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="41340" checksum="028A011EC1C42C66" modified="2016-05-11" version="1">MPSRVWLAVLFGSLSALGPMSIDMYLPAFPQIAAEMGVEVGRVQLTLSFYMIGLAIGQLMYGTLADRLGRRGPLLVGLFLFCSASLGCGLAWSVESLIVFRIAAALGGSAGMVITRAYVRDRFDAAESAKFYSLNMLVMGLAPIFAPLVGGQLLLLASWRALFGLLVVTSACCWLALFRSLPESLPSTKRVRHGFGKIARTYLGLFRQRVFLGYTLCGACMSGVMFSYVSGAPALFMEAHGVSAQHFGFYFGANAVGLILVSQFNVMLLKRFTTRQVLLAAYTANLAGALGFVAVVLSGWGGFWAALPFLWLCIASGGLIYPNSTALALAPVGAAAGSASALLGMLQFALGGVCASLVGAFHDGTGRPLAVVMVLVSAAGWSVLKWLPGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNT9</accession>
    <name>A0A139SNT9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711437.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03930"/>
    <dbReference type="EnsemblBacteria" id="KXU36172">
        <property type="protein sequence ID" value="KXU36172"/>
        <property type="gene ID" value="AXK12_03930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="355" mass="40563" checksum="6DBEB32A70EB6218" modified="2016-05-11" version="1">MPPEYPAARTILPKKRFGEVDSLRAIACALVVIAHARVWPPWLNDFLMDRVEIGAIGVVMFFAISGFVIPDTLRGMRLEGVKRFFIRRFWRLYPPFWVAFLLTLWIKPQYGVGDWIWDAVMLPSLGSRGHSIAQFWTLEIELVFYLAIAGLFLIFGHLGKKVLLLGYLLLLGLAVRKVTASDAVVDYDTMLPYLVVMFWGGICREIRRFDFYRYRWLTPKLGVNWARSSALGVVSGMTMIVLLMSYSAVRGTGRSCELAGALGILGFLLWVILTPVRIDWLSRIGRWTYSTYLFHFVVIFIARPLFNIPDFEVTSLVPPYFTALCFLVSFALGALVYRWIEQPSDHVGKQLTTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU2</accession>
    <name>A0A139SNU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711312.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03565"/>
    <dbReference type="EnsemblBacteria" id="KXU36228">
        <property type="protein sequence ID" value="KXU36228"/>
        <property type="gene ID" value="AXK12_03565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="259" mass="27288" checksum="0B8686A2F6748C25" modified="2016-05-11" version="1">MKLLVTNDDGIDSVFLHELCFALKAAGHQLYVVAPAKEQSGMGAAKTTTRGLKTAVVNPDLGGPTWTVDGTPADCVNVALEHLIEDTVEGVVSGINVGCNASLAFIIASGTVGAAWEGALHGLPAAAFSLDASEQVYRSLKENAGEPDERMYQSLKTAAHHAARLTGELLPETPHESFTVHNINFPEICRADAPLRRTVPAHLCAPGQFSPADEDGEHQFKWISGRDVSPAGLPTDFATLAAGEISHSILDYSRLGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNV3</accession>
    <name>A0A139SNV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36192">
        <property type="protein sequence ID" value="KXU36192"/>
        <property type="gene ID" value="AXK12_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="171" mass="19446" checksum="66491B96E279A885" modified="2016-05-11" version="1">MKGAAVYIDKNDQIADHARVSLISYEKASKLNFSAHIKEQLQETFRELFVEGKGAIDFGSGDRHSEHGRRLLYIDDLIIGDGSTLRIHGWRDKRDYILVRKNSVHLEDALKKIEFKGYDRNNIHLENYNNAYWVISATPESATYGSLLVASTVPLSLLRRRIKACLGRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNZ5</accession>
    <name>A0A139SNZ5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DZR_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03790"/>
    <dbReference type="EnsemblBacteria" id="KXU36263">
        <property type="protein sequence ID" value="KXU36263"/>
        <property type="gene ID" value="AXK12_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="268" mass="29921" checksum="82634ACE0D16A37D" modified="2016-05-11" version="1">MAASEPDFEQQRGSRLSLGQRLLDLFFPRACVHCRGRIADDSPLRHLCTRCASKLTPIKPPRCTTCGYPFHGAVDESLDTRLCPHCEGLNPAFDEGRTCVLLRPPARSLVHKLKYHAGLYVIEDMQRLFSGSPGLAQWLNSAVLVPVPLHPRRQRKRGYNQAELLAHTLTKLKPDAAEADTNAATRPQVETLLRRIRHTESQTRHNKQARLKNLKNAFALKKRAAVSPELRYVIVDDVFTTGATLNSCATVLRRAGARHIDVIAFGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP15</accession>
    <name>A0A139SP15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711255.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03405"/>
    <dbReference type="EnsemblBacteria" id="KXU36345">
        <property type="protein sequence ID" value="KXU36345"/>
        <property type="gene ID" value="AXK12_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="295" mass="32015" checksum="3E2D0A18609A74FC" modified="2016-05-11" version="1">MTDSASRSNRRCARRHPKRLSEVYRTAFVTGASTGLGAAFAQMLLDEGLRVFGTARDISRLESLTAANRSFTPVVLDLADGAAAERVFSEASESAGGFDIVINNAGYSVFGDFAQTDFAYWQAQIEVMLVNTARLAHAALSTWQKAGDGERPKALVNVSSLAAEFPLPFQSGYNVVKAGLSALNESLIVETAGTSVRVIDLRPGDYRTDFGSSVMRPNHCSDAASTQAVWERFAAMMRSGPPPAHAAQCLRRALLRRHSGTLRCGRFFQVVLAPFLVRFASLGLKRRVQALYFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP43</accession>
    <name>A0A139SP43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711298.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03525"/>
    <dbReference type="EnsemblBacteria" id="KXU36221">
        <property type="protein sequence ID" value="KXU36221"/>
        <property type="gene ID" value="AXK12_03525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="197" mass="22545" checksum="2241CF125806F1AC" modified="2016-05-11" version="1">MSDDDESFDLPACLARVRGGDQGASRELVDYLYPFVIRIVRTRVPRRLTEEDLAQEVFMKVFSRLDQYQGAVPLTHWVSRIAVTTCIDALRAQRRRPEFRWADLSEGEARVFEHAATPGGEVEAGDALAARELIDRLFSQLKPQDQLVLRLMDLEQKSGAEISAITGWPTTLVKVRAFRARQKLRKLFQTLERKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP77</accession>
    <name>A0A139SP77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711275.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03475"/>
    <dbReference type="EnsemblBacteria" id="KXU36356">
        <property type="protein sequence ID" value="KXU36356"/>
        <property type="gene ID" value="AXK12_03475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="138" mass="15808" checksum="C39DC1E3CEE350D3" modified="2016-05-11" version="1">MPEDRKDTNRALVRIGFDGTVHKTFRGSDAPERFANECRILRHLEARRCDFVPRLISADEAALKIVTTNCGRRVEHISDEKLKTLFAELETYGVRHDDPYPRNVTYRITDGRFCLIDFELATLLDEAASAHETSTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ39</accession>
    <name>A0A139SQ39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711197.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03100"/>
    <dbReference type="EnsemblBacteria" id="KXU36610">
        <property type="protein sequence ID" value="KXU36610"/>
        <property type="gene ID" value="AXK12_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="315" mass="35663" checksum="2968CDFF4175C62F" modified="2016-05-11" version="1">MPRYTVHKKILRDWPLYFFIIPSLVLVVTFQYYPVASGFYHSVFEWGGGDAKRFTGWENYGRAFTDTTFLNSFKVIGLLLIFNLIKMWPSVIIAVLIHRLKSDRWQYVYRVLLVVPMIVPSLVSLFIWKFLLDPNIGGLNALIEATGFKSVLVAVDNFFGWGVFFEDVPIAWLGQPQLILPTLFIWGFPWIGMFGVLLYLAGLQSIGTEVYEAADLDGIGPIQKFFYIELPLILTQIRLSLILMVMNTLGGFGFQLLMLNEAGGPGGRGMVPGLWIYNRSFVAGEFGYACALGIILGLIILGLTYINNRYIRIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ49</accession>
    <name>A0A139SQ49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711207.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03160"/>
    <dbReference type="EnsemblBacteria" id="KXU36620">
        <property type="protein sequence ID" value="KXU36620"/>
        <property type="gene ID" value="AXK12_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="14498" checksum="BFD0EFF3595BE337" modified="2016-05-11" version="1">MSARVALLLTGVIGLLAIICGAFGAHALRPQLLATGHLSAWETAVQYHLLHSVVLLAASLFLASRSEQSVEARWLRRAILAWCLGIVFFSGSLYWLALGGPRWLGPVTPIGGVAFIFAWAYLIPTALSMGKQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ57</accession>
    <name>A0A139SQ57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711170.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02985"/>
    <dbReference type="EnsemblBacteria" id="KXU36735">
        <property type="protein sequence ID" value="KXU36735"/>
        <property type="gene ID" value="AXK12_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="213" mass="22150" checksum="18530376439807ED" modified="2016-05-11" version="1">MKKDAVLSKLRAEKVVALIRAENSDGLLDCAKALAAGGLTSIELTMTTPGAIRMLEKATTELPDFLFGLGTVLDAETARAGILAGAKFIVTPALRPDVITLCRRYSVPIFCGAFTPTEIVNAWEAGADAAKVFPAEFFGPAYIKSIKGPLPQIEIVPTGGVTPANVADFLKAGAFATAAGSSLVEAKALKEKDWASITAKARAFVEAVSAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ89</accession>
    <name>A0A139SQ89_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ORF">AXK12_03075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711195.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03075"/>
    <dbReference type="EnsemblBacteria" id="KXU36759">
        <property type="protein sequence ID" value="KXU36759"/>
        <property type="gene ID" value="AXK12_03075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="255" mass="27242" checksum="3585F98AC1C53D24" modified="2016-05-11" version="1">MTRKKLIAGNWKMNKSGTEAVELVSELVTQLGPQTEVDVLVCPPFTALETVSRKLEGTSLKLGAQTMHAERSGAYTGEISAPMLRDLYVTYVILGHSERRALFGETDEVVNGKVLAALKNELRPILCVGETLEEREAGETLKVVQTQLEGGLAGVDAAQAASLTIAYEPVWAIGTGKVATAAQAQEVHAFIRELLGARFEPSLARKIRILYGGSMKPDNAPELLAQKDIDGGLIGGASLEARSFLELVNAAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR5</accession>
    <name>A0A139SQR5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711115.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02675"/>
    <dbReference type="EnsemblBacteria" id="KXU36877">
        <property type="protein sequence ID" value="KXU36877"/>
        <property type="gene ID" value="AXK12_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299369" description="Peptidase_S9 domain-containing protein" evidence="2">
        <location>
            <begin position="43"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="923"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122614" checksum="20D363E399379151" modified="2016-05-11" version="1">MPLSKPSTPWINLLKPCRAIRPRRRYACTGLFFWAATLTATAATTPIPIHASAAQPDTPAPQSQTREAPLSPLPAKRPLRWEDFDDWRSVSSPTLSPDGHWLAYSFMPARGDGEVVVRQLPAPAAKSAPPQSLHSSDDAHKPRARSYHISAGEIPPPVFPQGPTATGRPPPPRTVDHLFTGNSQFLLSLTFPPAQAQREARLKPARFVADPLRGQATDPRKTTQSLTIVDLPAGRSELVPEVQSVQVSLHGAWVAYLHEPLEPSPPAARPFNGPSRQSSPPPLARELAAPQPENRRLVLRELLPGSRRGWGSAARQIGGAGQQKSFEYVSEYSLSRDGRTLLYLVESPTRSRNGLYALALGSSSTAPQALLRTTKADAEQLSRLTWDAQQTQAAFLIQRKNGSYDVGLWKRGERSTTIALSAAHRPGLPPDLQIGEHTTLQFSSDGKKLYIGLVPRTPTASDALARDAEALIDPLERAYPEVWRWDAERLPARLNILAKVEPPRTYAGVLDLETGHYLQIGRPSRSSRPAFQELRFSEDGLWALAFDETPYLRLRDHDATYADVYAIDTRSGARRLIAKKLRGPSGDEGLPNVYFSPTVAGRSAAATPPPTRYVAYFDNGHWWAADLTSAATQNLTAGLPVSFAHEVHDKPEAPPTYGWAGWVADAASLIVYDRYDLWQLFIPEEGPGGPTQRPALNLSGGAGRSARLILRVQDTAAQYASGEGTALPLPPLWLRGLDPTQPLILRGEDERTHDTGFFRQPWPNPATRLGNPPQLERLFWSDKNTRFIGAARSDLFLLSASRFDEFPDLWVSDSAFSALRRVSDGSAQLAPFAWGRSPELIDYRSPAGAPLSGLLYTPPDFDPSRRYPLIIYLYERLSALRHSFFAPSFGANLNIPYYTSNGYLVYLVDIAYEIGAPGPSALDSVHAALDAVLARGDFVDPERIGIQGSSWGGYQVAYIVMHSDRFRAAVAGSPVSNMTSAYADIRWRSGRARLFQYEQSQSRIGAALTEAPERYLANSPLFAAHNLRTPLLLLHNDGDGVVPWSQSTQLFLTLRRHEKPVWLINYPYETHEIARYANRRDFQKRVWAFFEHQLRGAAEPEWMRAGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR48</accession>
    <name>A0A139SR48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">AXK12_02465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711075.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02465"/>
    <dbReference type="EnsemblBacteria" id="KXU37028">
        <property type="protein sequence ID" value="KXU37028"/>
        <property type="gene ID" value="AXK12_02465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="185" mass="20487" checksum="6EC7B103036DBA84" modified="2016-05-11" version="1">MPAANDIRKGQVIKFHGEPHLVMETQHRTPGNLRAFVQVKMRNLRYGKALDQRFTSTEPVEVLTTDRRTLEFSYADRGTYAFMDPETYDQVELTEQTIGELKNYLAPGGRVDVLFVDGAPLNVDLPSSVELKVTESADGIKGDTASNVQKPATLETGLVVQVPLFIKEGELIKVSTIDGSYMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR56</accession>
    <name>A0A139SR56_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711071.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02440"/>
    <dbReference type="EnsemblBacteria" id="KXU37023">
        <property type="protein sequence ID" value="KXU37023"/>
        <property type="gene ID" value="AXK12_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="525" mass="57212" checksum="43AB477FE0E9A096" modified="2016-05-11" version="1">MARLLAHWQRFLALYTKEIWQPALLDDTSLRGRFYAMLRVVSITITVFRDTKAASRASALSFSSLLGLGPLVAIAMLVAGMVLDDKDPDLAVNTLNRVIRFIAPQVAEYEAQTSSESGGNANLAVSAIAPNPTLQAGSGPALNRAPAEALPRPSSASAAASDSSESAPSTSLETSPEAEATVERMLSGFISGSRSGTAGAVGALTLILIVILLFKGIEDAFNEIWGLREGRSWLMRIIYYWTILTLGAVLFFASITLLSAGAFVNVFIAKLPFGAEILQLVRWLLPLSSGALVIGMLTLFYRYIPNTQVYWRAAFAGAVIVALLLLANNFLAFIYVRRVVISRSLYGSLGIMPILMFGLYIFWLYVLIGGQISYAVQNARFRSSQAAWGNLSHASREHLLLLVFLTVARRFQDCLPACSASQLSDIIKAPTQITNECLQRLVDMRFLTPIPAAETEPTSDFLYQPARPLNRTTLADFKARFESFGEEAASEEAMQALDPLLPRYIAALRAGRDNALLTTPIDQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRC8</accession>
    <name>A0A139SRC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711047.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02305"/>
    <dbReference type="EnsemblBacteria" id="KXU37093">
        <property type="protein sequence ID" value="KXU37093"/>
        <property type="gene ID" value="AXK12_02305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299339" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="208" mass="21950" checksum="86921301B59F1909" modified="2016-05-11" version="1">MNKSLLVSTLLFVGSAMTAATAAPQAFDFTDPKGVNAIQFKLDSLLEPISGTASGVSGKVHYNPENPTETTGKIVVATQSALVSNAVMTEHMLGEQWLDAANNPEIVFELTSLSNTQTEGNNTTATATGKLTLKGITREISVPVRLSYLPGAFGKRINKPEVPGDLLVIRGEFSIARADFGIMPGQHEDKVNPEIALSLAIVGSPAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRD2</accession>
    <name>A0A139SRD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711028.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02190"/>
    <dbReference type="EnsemblBacteria" id="KXU37159">
        <property type="protein sequence ID" value="KXU37159"/>
        <property type="gene ID" value="AXK12_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="93" mass="11295" checksum="5141001C7492290E" modified="2016-05-11" version="1">MKLRRFVTTLYWVLFCAGVVVAGAFFWQTQQEYQNLRTQERGVQARLEDAEQRLREQERTLERLRSDPAYVERVIRQRLGYAKPDEYIVRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRD7</accession>
    <name>A0A139SRD7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ORF">AXK12_02295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711057.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02295"/>
    <dbReference type="EnsemblBacteria" id="KXU37103">
        <property type="protein sequence ID" value="KXU37103"/>
        <property type="gene ID" value="AXK12_02295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="42998" checksum="3A90CD40271B8829" modified="2016-05-11" version="1">MPTAPLRTELFDYPVPEELIAQSPSVRRDDSRLLVVDRATHTISHHRFAELPNFLSAGDTLFRNNAAVLPARLRARRIIRSEGGATALGGAIECFLLRPHEAEPQNTSTWHCLLRPSKRLPVGAAFADTNREFSAEVLAKSADGTALVRLKSHRENETVPELARRLGSVPLPPYIHREKTEAPSTTGKDSQRARDLDRYQTVYADAARPVAVAAPTAGLHFTPELLGSLAARGVALADLTLHVGLGTFRPITTETIEAHQIHRERYEIPPHTIDRLHNTRGRRIAIGTTTLRSIEHYLRQTQACAPCPPLRAHLAEADLFIYPPAQFRGVDALLTNFHQPRSTLLCLIAAFLSPGSTDGITWFREIYAEAITRKYRLFSYGDAMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRE9</accession>
    <name>A0A139SRE9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">AXK12_02205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000014">
        <property type="protein sequence ID" value="KXU37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711030.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02205"/>
    <dbReference type="EnsemblBacteria" id="KXU37113">
        <property type="protein sequence ID" value="KXU37113"/>
        <property type="gene ID" value="AXK12_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="210"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="329"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="452" mass="50179" checksum="0365B4F24CA77738" modified="2016-05-11" version="1">MADFLDNTPQSDPNRCERALLVGVHTQTMRTGEAEELLEELRELVENLQISVVHRELVTLRGQPKPATLLGSGRTDQIITLAKHLDCDLIVIDESLSPAQQRNWEKLAGIAVIDREEVILDIFADRAQTREAVLQIALARMEYSLPRLARAWTHLSRQRGKGKLGGEGETQLEQDRRLVRDRITRLRAELVQVQKQRAVQRSKRLRVPVPTASIVGYTNAGKSSLINALTGAEVLAADKLFATLDPTTRQLLLRGNQKLLVTDTVGFIRRLPHRLVEAFKATLEETIVADFLIHTLDLANPNFEEHHATTLGVLEELGAADKPIITVFNKIDLATEADRSRARQLVPDALFISAHTGEGLDALEAQCVELIANTQGSAELLVPHERYDVIARLHALGHIQAQIHDEAAGIYVRARIPLAQTGFFKPFVLQGEWPSELDETVEPGLSPAAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRF8</accession>
    <name>A0A139SRF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711048.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02310"/>
    <dbReference type="EnsemblBacteria" id="KXU37094">
        <property type="protein sequence ID" value="KXU37094"/>
        <property type="gene ID" value="AXK12_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="121" mass="12951" checksum="3DC75F65C9129FC4" modified="2016-05-11" version="1">MTDAEIQPLIDEASYDYAMGEAASALTKLRDAAQSAPHSFDLWHTLAEIALGAGLTDEALAAAEKAHALRGDDLLINTTLSRIWVERGDKARAERYAAQAKILGWKEQLKGGASTAAPTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRK2</accession>
    <name>A0A139SRK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000012">
        <property type="protein sequence ID" value="KXU37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711019.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00010"/>
    <dbReference type="EnsemblBacteria" id="KXU37173">
        <property type="protein sequence ID" value="KXU37173"/>
        <property type="gene ID" value="AXK12_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="683" mass="71361" checksum="9BFC07115B20C752" modified="2016-05-11" version="1">MGLPHERYLRPRLYVAAALALPVLALSMGEMLAPWAFAWLPPTLNGWLQLALTTPIFFWAGAPFIRRWWYSIRERDTNMFTLTVTGTGAAYFYSAASLLFSQHFPETLRSGMSAMHGAAAGMSGAAGLPPLYFEATAFITAIVLLGQIIEQRTHSRTDAAIRGLMQLAPKTAHRIRAQDGSEEDVPVDQIRPGDLLRVRPGESLPVDGVLLAEPNGARIGAEIDESMLTGEPLPVEKRAGDTLSAGTLNTTGSFTYRAERVGSDTLLAQIVALVEEAIESEPPIARLADRVSAWFVPSVLGVAALTFFAWGLLGNEHAWLFGLLNAVAVLIIACPCALGLATPVSLVTGIGRGAQVGVLVKDAAALEALSGSTTLIIDKTGTLTEGRPTLSAITPLGGRSESEESLLGLAASAEAPSEHPLGRAIVAAAQKRGLSLLPVSDFHATPGAGVRATVAGRRVEITRASAEEIAAAPLDSSANTQTLVCLRIDGAPAALIALADAIKPSTPAALAALKAQGFHIIMATGDREETARTVAAQLGLDEVHAALSPADKQKLVRAVQARGERIAFAGDGLNDAPALAAANVGIAMGTGTGVAINSAGLVLVKGDLAALARASTLARATLRNIRQNLFWAFAYNSAGIPIAAGLLFPLTGWLLSPMLASIAMCLSSLSVVTNALRLRRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRU8</accession>
    <name>A0A139SRU8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat-shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_00015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000012">
        <property type="protein sequence ID" value="KXU37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711017.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00015"/>
    <dbReference type="EnsemblBacteria" id="KXU37171">
        <property type="protein sequence ID" value="KXU37171"/>
        <property type="gene ID" value="AXK12_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="965"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1096" mass="119479" checksum="F5C162B0A3E08959" modified="2016-05-11" version="1">MIDRLIHWSLHNRFVVIAGFLALCAWGIVALQRVPIDALPDLSENQVIVYADWPGRSPQEVEDQITYPLSASLQGLAGVKAVRASSMFGFSFLTVIFEDSVDTYFARTRVLERLSSLGPDLLPAGVVARLGPDATGLGWVYQYYLKDESGTQDLGTLRSLQDNVLRYELASVPGVAEVASIGGFVRQWQVEVSSLKLQQYGLTLGEIMDAVAAANLNVGGRTIEENAAEYVVRGVGLVERAEDLEAVVLAPRSGTPLLLRDVARVQIGGDFRRGTLDVDGREVVGGIVVMRYGENAHRVIADIKTRLATLAPSLPAGLTIEASYDRSDLIDRAINTLKHALTEEILLVTLAHILFLFHFRSILIVTLPLPAAILISFILMDRLGIPSHIMSLTGIAISIGVLVDAGIVMTENVIRHCERATLAKQKTDARRPRADRTGDDPAANKKDLPALTPKEIFALTLSASRQVGRPMVFSMFIIILAFVPVFLLTGQEGKLFHPLAYTKTFALVGAVLLAVTAVPVFCTLLVRGPFTPESENWLMRALLRVYDPLLNAALRWRKTVLALATALLAFSCLVAFGVPRGLRARLPDSLATRANGFGSEFMPPLEEGALLFMPVLLPATSLTEVKRIMAWQDRVMSEHPAVASVAGKLGRAETATDPAPVEMIETTILLKPQSEWPAGTTKDSIIADLSARLMQVPGYVPGFLQPIENRILMTSTGIRAQLGIKLFGTDLSDLQEKAFEIERIISQVEGAVGVAPSRVQGKPYLEVVARRDALARYGLSLRQLYDTVEAGIGGRVVSTTLRGREKWPIQVRLEHGDRSDIDALAELPLNTPSGAKVRLSQVADIRRTVGPNEIASENGRLRVFVQANVVGRDLGSFVAEVRERLDRDFSPSPGQTLEFSGQYEAQLRTRRTLALIFPAVIGIIFVLLVMTFNSASEAAHVLLAVPFALTGGVLLQALLGYPFSVAVWVGYIALFGTAIQTGVIMVVYLEEALAKRREAAHAQGRTFERPDLLAAIKEGARLRLRPKVMTVATTIASLTPLFWLDRSGVEVMRPLAAPVVGGMLSSLLHILIVTPVIFAWIQERKLKKASKVTQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS04</accession>
    <name>A0A139SS04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37366">
        <property type="protein sequence ID" value="KXU37366"/>
        <property type="gene ID" value="AXK12_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="221"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="691" mass="76722" checksum="64F7AD78DA0071EB" modified="2016-05-11" version="1">MADQSSVTALERLQVVSTATRTERLLSEVPIRTEVVTQEDMHMRGTFNFSQAVELFNGVRVESTCQNCNTSEVLMLGLGGAYNQILFDGAPLMSALGGVYGLEQIPTAFVDRIEIVKGGSSALYGAGAVSGVINLVPIQPLRNGGFLQAGVDVQKGEPIWLADGRLDRVFAGGKGGLSLVFQSSQNDPIDYDGDDYSEITEKELGVVGAQVWFAPTAKTRLRANYQYTWEERRGGNRFDQPEYLANIAESLQTKYHRGGVSWEQDVTADFDFSIGYSFAYIERDSFYGGLGDVVTDPNAPGYDPDELDPTIAGSAASDSFGQYGYTEDPLHYIDSQFNYRLEKHAFAAGIQYKWEKVRDYNRDFLGKTLATFVDDSFSNVGFYLQDEWTATPTLSVVLGGRVDKSSELDDAIFSPRVALAYEATPTLKLRASVATGFRAPGVFDEDLHVDTLGADQIRIRNDAALKEEQTITGMVGLEWRNDPANATWGFDVTASLTDIDDTFLLGPTLTDPVTGDLYQVRSNASGSRVEGVEANWVYIPNSQLRFELGAAYFQSRYDEAEDIFDDTDVGGTTIISTRDYLITPEWSGVAQAIWTPMPEFNVFLGVKYVGAMDALHNRLGELRRTPDFWVVDFGFTRHFDTGKHHIDVTLGVKNLFDERQKDLERGADRDNDYVYGPRFARSFFITAKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS86</accession>
    <name>A0A139SS86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710993.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02075"/>
    <dbReference type="EnsemblBacteria" id="KXU37407">
        <property type="protein sequence ID" value="KXU37407"/>
        <property type="gene ID" value="AXK12_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="19828" checksum="52F05D9F7838159B" modified="2016-05-11" version="1">MKTNKTSATKAPRTNARTGNTGVSDEPKTATRKTKGSSSPATAKTAKSPTPLTSARVTKAAANAKKALSPLTPTVAKSPKPAAAKKPKTLVAKPKAAAPDTAAKAAAVTTIEAFIDVGFGNRLTLRGEGAGLSWERGLTMNCLGSAEWVITLEADASTPLSFKFLLNDEHWNIGENYSLTPGKTGAFTPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC9</accession>
    <name>A0A139STC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent chaperone ClpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01350"/>
    <dbReference type="EnsemblBacteria" id="KXU37833">
        <property type="protein sequence ID" value="KXU37833"/>
        <property type="gene ID" value="AXK12_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="416"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="942" mass="104121" checksum="1ED80E9EC9C50AE5" modified="2016-05-11" version="1">MDFNKLTQMSRQAITEAQSLARRHSHSEVETWHLLAALLAQEGGLVPGLLEKLHITPAALTLALTRELDRLPKVSGSVDTSRVYVTQAFNEVLTRAEAETAALKDDYTSVEHLFLALLDVGKPEPLKKLLASFDLDRASVLHVLREVRGAQRVTTDNPEATYQALEKYGIDLVAQARKGKMDPVIGRDEEIRRTIRILSRKTKNNPVLIGEPGVGKTAIAEGLAQRILRSDVPEGLKDKTIFALDMGALVAGAKYRGEFEERLKAVLAEIKQSEGRVILFIDELHTIVGAGKTEGAMDAGNLLKPMLARGELHCIGATTLDEYRKHIEKDAALERRFQPILVQQPSPEDAISILRGLRERFELHHGVRIQDNALVSAVLLSHRYIADRFLPDKAIDLVDEACAAVRTEMDSMPQELDELSRRVLRLQIEEAALAKEKDEPSKTRLAALRKELAETRAQADALRLQWEKEKASVQKTRKLREALDAARLEMDAAERAYDLNRVAELRHGKIPQLEAELKQTEQAETRAGESPETTSKADARAEAPALRSGAATSSGKAATGADTSSGRPAAAPVASSDTPAPAAESASDTETNAAPKTRSTLFREEVSEEEIAEVVAKWSGVPVTRLVEGERDKLLRLEAVLHQRVIGQDEAVTLVTEAILRARSGIKDPRRPVGSFLFLGPTGVGKTELAKTLAETLFDSEAAIVRIDMSEYMEKHSVSRLIGAPPGYVGYDEGAQLTEAVRRKAYAVVLFDEIEKAHPDVFNVLLQVLDEGHITDSQGRTVDFKNTILIMTSNIGSRFLLEGVSTNAEGTIPETVRESVMSELRASFRPEFLNRIDETLLFKPLNLDEITQIVDLLLADLNARLADRRIHVSLSPKAREWAAEKGYDPVFGARPLKRFLQRQIETRLARALIAREIPENATIHFSIENDELVMRTSTERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STF2</accession>
    <name>A0A139STF2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01310"/>
    <dbReference type="EnsemblBacteria" id="KXU37845">
        <property type="protein sequence ID" value="KXU37845"/>
        <property type="gene ID" value="AXK12_01310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="188"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="490"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="623"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="899" mass="98178" checksum="8330CFF7B7630EE9" modified="2016-05-11" version="1">MRPKGNPDLALLAPLAAEPVIRRTLPNGLTLLIKPDHRAPVASIQLWVKTGSIHEDTALGSGLSHYLEHMLFKGTRAPRPRSARQISEQVQAHGGAINAYTTFDRTVYYIDLPSEHTPLAIDILASMALRPTLDKAEAEKERDVILREIAMGEDDPDQRLAQALFSTAFRQHPYAQPIIGHRELFERITHDELVRYHRARYVPANMVLIVTGDVSPEQIAHEAETHFAAAPRLPLPPLYIPPEPQQLAPRTWEQSADVELTRAGIAWAIPGLSHPDTPALNLLALLLGGGDSSILWQTVREKKGLVHAIDATSWAPGSNGLFYIAFTCDDAKRDAALAAIHAELDRVKRSGFRPAQLRKAIRQLVVGEINTRKTVSGQASRLGAAEVVIGDLHFAQSYFERLAALRPADIQHALRRYLIPQSSSTVSLNPKPAKDAKPALPQSKKTRPKPPPSSTPTPAFTAHTLPNGARLLLRPDASLPNVHLRLCGLGGGYCEPADRRGATSLLTTLLTKDTQRNSAAQVAQKIEEVGGSFYPMSGNNAFGLALEVLPSDLPLAHELLADAVLRPTFRKSTLEQERSAQLAALQDSNDNPVSYGLRQLRRHFFGAHPLATGPNGSEDTLSKITARDLAALHTQLLAPQNLVLVATGDFDVKRMTRSAEKLLKNLPQSSASPRHELSPLTQPAPTHSAPQKQPKALSAAKAATTNAVTAPPSPNTGIFSERRPGQQAVLFEAYPAPSIRDDGFFVSEVLDELFSGMSSRLFERVRETLALAYYVRSSRIIGTDTSMFYFYAGTEPGKEPAVLREIEAEIARVARGGVTPSELSRCKTRLKAGHQMGLQTNSQRALQAALNTLYGRPADDSADYAQRIDAVTRGDLASFAKHYLRPDQRLRLTLSPENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STI5</accession>
    <name>A0A139STI5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37824">
        <property type="protein sequence ID" value="KXU37824"/>
        <property type="gene ID" value="AXK12_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="96" mass="10462" checksum="4768F180DEF1E583" modified="2016-05-11" version="1">MIEPLIKDSLIRLSTATQACGNHVNAASDRGQNADEQAAMITREIDTLDSLFAEHRRRLHPQLAHFLANRSYAKALAFLGGEAEGIPAAARGKNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN6</accession>
    <name>A0A139STN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710799.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01010"/>
    <dbReference type="EnsemblBacteria" id="KXU37968">
        <property type="protein sequence ID" value="KXU37968"/>
        <property type="gene ID" value="AXK12_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="116"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="116"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="218" mass="23018" checksum="5DFD9907062A1D7F" modified="2016-05-11" version="1">MFTGLVEEKGRLLDFARVGEGATAGWHLTLAAERVLSDAKLGDSIAVNGCCLTVVAIDREAGALTFDVLEETRRLTNFAALSDGRVGGASPARASGSQHLNLERSLRADARLGGHFVSGHIDGVGTIESLAQHGADTRLRVRLPEAAAQRGPIVHKGSIAIDGVSLTVAEVDADGFTVWLIPTTLAETNLGEKQPGDPVNLEYDLLGKYVAQIIDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ0</accession>
    <name>A0A139STQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710837.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01220"/>
    <dbReference type="EnsemblBacteria" id="KXU37811">
        <property type="protein sequence ID" value="KXU37811"/>
        <property type="gene ID" value="AXK12_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="378" mass="41560" checksum="7E1811F01C74118A" modified="2016-05-11" version="1">MAHVVIKDLVKTYPEKHGPGVTAVKGINLEIEDREFMVLVGPSGCGKSTTLRMIAGLEDISGGSVSIDSKVVNNVMPKDRDIAMVFQNYALYPHMSVYDNMGFGLKLRKFPKKEIDTRVREAAAMLGLEELLDRRPKALSGGQRQRVAVGRAIVRKPKVFLFDEPLSNLDAKMRVSTRAEISKLHSRLGATMIYVTHDQVEAMTMGDRICVMKDGNIMQVATPMTLYNSPENMFVAGFIGSPPMNFFHGRLEKQGGQTVFIEANKNATPIQVTLTDELATKAAAYVGKEIVFGVRPEDAQDTLTLSAPAPEHTIEVTVEVSEPMGSETYLYLDTGAQSFIARVGATDRFDAGQKVQITFSMDKVHLFDPKTENVIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ2</accession>
    <name>A0A139STQ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710800.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01015"/>
    <dbReference type="EnsemblBacteria" id="KXU37969">
        <property type="protein sequence ID" value="KXU37969"/>
        <property type="gene ID" value="AXK12_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="324" mass="35789" checksum="0226784AE0CE1529" modified="2016-05-11" version="1">MRASLTALTEELRRLKSLGVREIFAPPETLERLRSALAKRKPAKPESAASLAVAHFDAAPERVTRVGATPEITTSAPGREVTPVRQTLEPVTTPVRQPKPQLIEAKFTLPAEGTKAERLAALREIVLADKTCRAQLRPGKQVVFGVGNPEAQIMFVGEAPGAEEERQGEPFVGPAGKLLTKMIQAMGLEREQVYIANIMNWRPQMPTQNAAGEQVGNRPPTPEEMAYCLPFLRAQLEIVAPQVIVALGATAARGLLGHDSFKALGELRGKWREFAACPLMVTYHPSYILRNQSNRSKRVIWEDFLKVMERAALPISEKQRGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ3</accession>
    <name>A0A139STQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">AXK12_00870</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710774.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00870"/>
    <dbReference type="EnsemblBacteria" id="KXU37945">
        <property type="protein sequence ID" value="KXU37945"/>
        <property type="gene ID" value="AXK12_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="730"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KXU37945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="830" mass="89594" checksum="8F116162430EC40F" modified="2016-05-11" version="1">MKISLNWIKDYLPALDASPEEISRAITFLGFEVEAVLHSGAPALENVVVGKILTREKHPNADKLSVCTVDVGEAHGGVRTIVCGAPNCDAGRHVLAALPGAVLPGDFKIKSSKIRGQVSDGMLCSTDELGIGTDSEGILLLSGEPALGTAANDVLPAGDVVFDVEITPNRPDCQSHLGLARELAAWFKLPLVYPQSRFRGLAEDAPERRDLLAAVQVDTPVECPLYSAHIISGVKVGPSPDWLQARLSAVGLRPINNIVDVTNYVLLEYGQPLHAFDAARLGGDARVSPGGQRLHIRHAQAGETLTTLDGKARALEPPTLVIAGAETPLAVAGIMGGEASGVSDATSDLVLECAIFKRQTIRRTSKRLGLSSDSSYRYERGVDPHMALEAARRAIGLILETAGGEVVGPVFQVGGEVPWQREVVVTHDYICEKLGFDIPAEAMRAAFESLELRITREEPTEARGPAWTLAIPSWRQDLDRPIDLVEEVLRVYGTDKIPATPLTSPGLLAEDDPTVRFNRRVTDFLVGHDFNECASYTLRSGEELSTWVSQTAAAELALANPFVADQSHLRPTLLLGLLEALHLNQSRGTPVQRLCEVGRVFIESNGQTHECASVGFLIAEDTTTRHWLKREAADFYTAKHLVAALANAAGIDFARQPVEPTSGDFLGWQDGHAARAGDLEKLGWKARFGLLDLALVKSLGIEGKVYAGTFSILPEKLADAQTRRRFAPFSLYPATLRDLALVVPAALPAEDLRKQLQKTARAVVGNAFAVESVALFDVYRGESLGDAQKSLAFSLVFRAEDRTLTDDEVNAAFQKIQDELLASTGYALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STR0</accession>
    <name>A0A139STR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_00985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710794.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00985"/>
    <dbReference type="EnsemblBacteria" id="KXU37963">
        <property type="protein sequence ID" value="KXU37963"/>
        <property type="gene ID" value="AXK12_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299422" description="SLBB domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="209" mass="22762" checksum="DF661E9F24C84240" modified="2016-05-11" version="1">MTRSVYAQALSCLLVFLASFAFASAQISSSRYGAAPTTYRIATNDTLRVVVFQESDLEITARVDASGMVNLPLLGQIRIAGHTIPEAEQAIARAYQNERYLRSPQVTISIVDYAPREISIQGQVRAPGRYPLPIEQTMTLVELVTRAGGFTDVARGSAVTVTRVKADGSTEKFVVDVQSLIRGRSRASVEDNSLALQPGDIVYVPERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STW3</accession>
    <name>A0A139STW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710784.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00935"/>
    <dbReference type="EnsemblBacteria" id="KXU37954">
        <property type="protein sequence ID" value="KXU37954"/>
        <property type="gene ID" value="AXK12_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="377"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="618" mass="68127" checksum="C1D2667E143DCA20" modified="2016-05-11" version="1">MKRALPLLVLALAILWLANTLRDHRADKQLDLEGFGRLPILANGRIKPLDTVARSSLLQLQGRQRVQSGSGATLAPTAWLATVFFDPARADRMRTFEVVHPEVLTLFNLRPEDGDSGKRFSFVQLSGGFPELMRQSQLAQQTDTAARSAFQRAVIQLHLNLNLYHELKHTLAPPDSADFLGELLNFQQNLPAGVAAVRARQQNEPYDEAAFNAMLALGTRFDTLSTASTLRPIPPPSGSANDSSHADWRTTGAALLGTFETGLVDHNVLAYAGLAQAWRGQKHAQFNEIVRLYRDQLQTQFAPELRKTDTEARFNAAAPFYRSMLLYVLAFVLAIFSWLKWPDVLGRTAFWLILCAFIATSAGIATRMWLEGRPPVTNLYSSALFVGWGAVLLCLVLEALYKNAIGSVAAGLIGFSTLLIAHHLSLGGDTLEMMRAVLDSNFWLATHVIIITIGYSATFLAGFLALIYILRGCFTRSLDRPTAAALSRMVYGIVCFATLFSLVGTVLGGIWADQSWGRFWGWDPKENGALIIVIWNAIILHARWGGLVRQRGLMCLAVFGNIVTAWSWFGTNMLGVGLHSYGFMDAAFWWLSAFVISQLAAIALALLRPISPQKTAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STZ8</accession>
    <name>A0A139STZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710755.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00775"/>
    <dbReference type="EnsemblBacteria" id="KXU38069">
        <property type="protein sequence ID" value="KXU38069"/>
        <property type="gene ID" value="AXK12_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="328"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="411" mass="43649" checksum="761A555BF830BFD5" modified="2016-05-11" version="1">MKTHTAEAPGRLDFMGGVADYSGSLVLEMPLSLTTRVKISEFPPKRISRACEGAAPFSFVFVSETYGEERVELGTPPSEVPQWARYPYGCLWLFAKEQRIRLDKLAVDGCGGLRFEVSSRVPEAMGVSSSAALEVATLRALELFFDKPLKGQTTLARLAQRVENEIVGAPCGLMDQLASANGVKGALLPILCRPDILGEPVKLPKGIVAVGWPSGVKHAVSDSPYATARAAAFMGKKLIEATLGRRLKHATELAPSVVRSLSLEALPERMSGRAFLEKCGGVDDPLSTIEPGREYAPRAGVSFPVEESFRSEAAVALLRGLGARNRAESLAALGELLYQSHAGYSSIGLGCPETDEMVEGVRALGPKRGLYGARVSGGGSGGTVVVLLEQAALPALTRLAKKLGRPTTFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUA8</accession>
    <name>A0A139SUA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710758.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38072">
        <property type="protein sequence ID" value="KXU38072"/>
        <property type="gene ID" value="AXK12_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="138"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="287" mass="31721" checksum="A728EAED3109DF19" modified="2016-05-11" version="1">MLGSTLGFAAMVIFIRLASTRGIPTNEIGFFRNFFGLLVLLPFVLKRGEPFPRTRHFVRYLLRTTIGLTAMLCSFWVIAHLPLSQAISLSYSAPIFVTVGAILILGETVKLRRWAAVIAGFVGVLVILQPWSHTFSPAMLVAVLAAALTATVSIQNKQLSQLDPPETVVLYTYLFWVPMSLVLALPIWQWPDTLGWAWLLGTGIFGTLGQLLWVRALRIGEVSALQPISFTQLPVVALFGWWLFDETLDHWTPLGAAIILVANTYIARREAQLARRTANAIPAPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH76</accession>
    <name>A0A139SH76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000064">
        <property type="protein sequence ID" value="KXU33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00605"/>
    <dbReference type="EnsemblBacteria" id="KXU33909">
        <property type="protein sequence ID" value="KXU33909"/>
        <property type="gene ID" value="AXK12_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12951">
        <property type="entry name" value="PATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299271" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1202" mass="125716" checksum="C19597120BDAE0A1" modified="2016-05-11" version="1">MIYKRLFSACVAGFVFGGLGLSSAIAQIVPPPIPSTIKEWKGPNGGNWATAGSWTGLGPPLGSDNVLFGHEPVGGVVPSPTDDSIRQTVNTGATNIVVRSLWFKAGLWYTLSGTATIELNSGTSDGHVLVVTNDATAPKQSETNIENDIRLSGSFGGPNNRARIENWSEGGLRIGGLFRASDHNVQFGGTGAIHIANRIVNQDGNRSNSNFYIQGSTGTAENVHLILSGNNDQNYGGVINVNARGFLIVKTDQALGEGSNKVVHEGGTLGLRSHRETALDYKQPQQNNFISLYGDGIVRSADTRRIGALYNDGGWNSLDMRIDQTTQETAPTGFGSRGDRAGGLELKNQVKLTTQFIKLGPGLIVLNNTRGSGEANNWANGTVLRAGVLRFSSAAGSPTASNFVFDGGAFGGILELGYGTSTFNYNLGTGGGNIRWADTGDGGFSAFGGARTVNIGGGATLTWGSTTHFVGDGQALLLSSRYANSVITFANAINLNGALREVRVERGEDSAHGVLSGGLSGAGGGLVKTGDGLLQLTGSNPYSGATRIVGGALRGAAANTATNIQLAGGVLGLDANLTLRLGTSGNQIRWLGSGGFAAYGANRNVTFVGNGGSAVSLTWGTTGGFIGSDQELRFGHHTANGTVLWNNALALGSGERTIRIEGGQQISGTVVNFLLAISGTATLNLIGNGRIDLSANNSALSSSINIYGAELRLLGSGKLGAAAAFDIRHGGALVIRNTNAASDTNRIGDTAAITLAAGTVRLEGAATPISERIGELSLESGASTIELIRNTFNPSVELHIEALTRDSDSRATLNVSGDLSNTLLSLKVEQDASGHLVGGIIPWATNGNEWIKVVGNALKALDNSDYHTGGGSTWTNAAYNVKAIGGTALTGNRTINSLIFGNSLNLSGRSLTLNSGGLMNSGLSQILGGLGSTITTSGGTRPLYIHNNGQLSLTGSVALTGGMDVVKTRGGDLIFNNNTSVTHHIGSLYIHQGTVELGGRGTLQVRRITIGDGAGNDRLILPGNRWNPITSSNGLPSITLRGTRYDPRGPEYGGDQAVLQLGGNGPNYGAGTKQHLAELRIEGRGTIDWRGGEVGQANILWIDTLSFSSTSDILFIRNWYEYEDLFLVKRVHNGVQFDDLKLNQIVFEGYQDYFTTLKDYDADYWQITPWGAKPAPEPSTYGAILGAAGLALVTWRRKRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF4</accession>
    <name>A0A139SHF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_08010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713219.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08010"/>
    <dbReference type="EnsemblBacteria" id="KXU33976">
        <property type="protein sequence ID" value="KXU33976"/>
        <property type="gene ID" value="AXK12_08010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="143" mass="16332" checksum="2AECD5465F049721" modified="2016-05-11" version="1">MARTFRRRQNQQPIAELNITNLMDVAFVLLIIFMIASPLIQQEQTIPVNLPSESERPQQSPPPEQRFQTISIDASGHYFWGAQAVSMNELSRLLENEARQPEPAAIRIRAASQLQYQRVVTLMDEIMKHKLSKISFDTQVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH8</accession>
    <name>A0A139SHH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713286.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34007">
        <property type="protein sequence ID" value="KXU34007"/>
        <property type="gene ID" value="AXK12_08220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021913">
        <property type="entry name" value="DUF3526"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12040">
        <property type="entry name" value="DUF3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="483" mass="51711" checksum="3E6E274B0C6C28AB" modified="2016-05-11" version="1">MNFRFFFWELRHLRSEPTFAVVLLLLLVLSGLAISNGSSRLRDQQAKQAAALSAVETSAAATAELARKLDSGEATTPSFSDPRTPSGFALRHMVANAVKPSRALAALSVGQSDLYPSVHKLALNSRDSALTAAEYENPQRLLIGSFDVAFVVIYIVPLLLLGLTYNLVSAERERGTLPLILLQQGSVKRLALGRSLFLGVCVLLALVAILLGGLSVTGLLGQVSGGALFGWLAVAFFYGLFWVGLAVFVSSRGGASATNAVVLAGAWLVFTIIVPSTVSVAAKAIYPVPSRMAYIDAQRVVTEEARNRQSQLLAEYFEDHPELASAEAQAAVAAGTQANPRLIAHLGYQEQERLLAPVRARYTEQLERQQGLVDALKYLSPALLAQAAFNDLSGTGMERHREFQRQAGDFHDALRDFFQPKIIAGEAFTEFDQVPRFAFEEAAATSANATAQWLVLALGAALLLAASLPGLGRYSPNGVNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ8</accession>
    <name>A0A139SHJ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="12" type="ORF">AXK12_08235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713358.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08235"/>
    <dbReference type="EnsemblBacteria" id="KXU34045">
        <property type="protein sequence ID" value="KXU34045"/>
        <property type="gene ID" value="AXK12_08235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="231"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="431"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="757" mass="84261" checksum="8FE6ABE2086137B4" modified="2016-05-11" version="1">MIVGVHPLAGFDKLLHYRVPERLRGDLRLGALVRVPVLRALRLGVVGEISPPAAPPDFPLAKLKSVAELVYPFPALSPDLLRLARWMSRYYAAPLDGIIETMIPVAVRNGAAIKEEVLLRAISEEERVSELPPTSGTPAKKAPRAAPKQAAVYEFLARQPHPQPKRLVLERLGVTPAVIAGLVKRGLVREERRRVQRHAYADDWASGEVAAAQPPVLNTEQAAAAAAIEEKCAGGDFGVTLLHGVTGSGKTEVYLHAIDRALKTGGGVIFLVPEVALTPQTVARLRARLEAIAPGHACVVWHSRLSEGERLDGWLALASGEARVVVGARSAVFAPVQDLRLIVVDEEHEPAYKQDESPRYHGRDVAVYRAHLAGAHCVLGSATPSLESYANVQAGKYAFLELKQRVDDRRLPFIDVVDMRVEVMRSRGLTILSQRLVRAMQDRFEKREQVILFINRRGYSSSMICQDCGHVEECEHCSIAMTYHRTDETLRCHLCGAQRSAPARCPKCGSPKIRWRGLGTQRVEEAVRRVLPQARIERMDTDTMGKKNRFREVLAEFRAGQIDVLVGTQMIAKGLDFPNVTLVGLIDADISLHIPDFRASERTFQLLVQVAGRAGRGDLAGEVVVQTFTPQAEPIQFSRHADFAGFSEAELKLRRDFKYPPYRHLIKHLFRGPNPEKLQFYAEQWAKRVESELGAAVELRGPSPSPIEKVKDHYRWQLWYFTENVSKTVPQLVALQREFPWAEDIIQVLDVDPVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ4</accession>
    <name>A0A139SHZ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_rep/recomb_RecO_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713187.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07960"/>
    <dbReference type="EnsemblBacteria" id="KXU34198">
        <property type="protein sequence ID" value="KXU34198"/>
        <property type="gene ID" value="AXK12_07960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="23045" checksum="FD8E596BF2624DD5" modified="2016-05-11" version="1">MAGLTLSTQGIVLLKRPPKANFQLLTLFSAEHGHLSLWQRLSKSSSSKTGAAPLDLFDEAEFLAESPNQGQSWFIKEAHLLHRPSGIARSYDSLQHACGFTTTLARNRVPEEVRAGVMQLLRRSLDAFANHMRPDITHLKALYSFARDEGYPLRQHWLPTLPAALRSLAQSVLGQPLADQNPPAQAVTALHSHLAHYLRHHTEILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI22</accession>
    <name>A0A139SI22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713136.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07780"/>
    <dbReference type="EnsemblBacteria" id="KXU34171">
        <property type="protein sequence ID" value="KXU34171"/>
        <property type="gene ID" value="AXK12_07780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18786" checksum="D7BB5EDC556CB4BE" modified="2016-05-11" version="1">MKKPINLAVACSENRVIARDGMTPWRIPEDLEHFHRLTAGQSVILGRLCYEIWPRVSLDGRTPIVITQNRALAKPGVHIAADVAEALAIAHSLPGEIMVCGGQRIYEELIDAADRIYLTIVHVEIPGDRFFPEWRHLSWRESERRTSQDAHYRYTFSTLDRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI75</accession>
    <name>A0A139SI75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <shortName evidence="9">ENR</shortName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabV</name>
        <name evidence="12" type="ORF">AXK12_07850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TER reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713154.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07850"/>
    <dbReference type="EnsemblBacteria" id="KXU34180">
        <property type="protein sequence ID" value="KXU34180"/>
        <property type="gene ID" value="AXK12_07850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01838">
        <property type="entry name" value="FabV_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl_reductase" evidence="11">
        <location>
            <begin position="82"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Eno-Rase_FAD_bd" evidence="10">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in discriminating NADH against NADPH" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="394" mass="42336" checksum="3D0E376B214C3CF8" modified="2016-05-11" version="1">MIIKPKVRGFVCVTAHPEGCAAHVQEWIDYVKAQPSIQGGPKKVLVIGSSTGYGLASRLSLAFGARAATLGVFFERPSEEGRPATPGWYNTIAFTKAARADGLYARNIMGDAFSDEIKAQTIDAIKADLGQVDLVVYSLASPRRTHPKTGAVHKSCLKPLGAPYTNKTVDTDKGIVSSITIEPADEAEVADTVAVMGGEDWELWIDALRAAGVLAPGAQSLAYSYIGPEVTWPIYQNGTIGMAKNDLSRAAKAIDAKLSPSGGRAFISVNKALVTQASSAIPVVPLYISILYKVMKAAGLHEGCIEQMHRLFATQVYNGHTPTFDEAGRVRIDDLEMRPEIQAAVAALWPTITTENLESETDIAGYRTEFLKLFGFGLNGVNYDAETEPHIPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI86</accession>
    <name>A0A139SI86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate starvation-inducible protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713173.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07920"/>
    <dbReference type="EnsemblBacteria" id="KXU34190">
        <property type="protein sequence ID" value="KXU34190"/>
        <property type="gene ID" value="AXK12_07920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="118"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="36844" checksum="3E8596271215AC88" modified="2016-05-11" version="1">MSAAPAARATSKSLHFATPRQRAQLYASREENLLRAEALLGVRLTAREDWIKIDAPTTAALARAEAAFTFLEAARAQGMTIRTPDFERIVETFARDEGDSLQTLITQPLIIPTHRKSIVPKTLAQKLYLQSILQQSIVFGIGPAGTGKTYLAIAAAVRALLQNEVQRIILTRPAVEAGEALGFLPGDLREKILPYLRPLYDGLGDMLASDEIARLTEKGILEIAPLAYMRGRTLSNAFVILDEAQNTSPEQMMMFLTRLGEDSRMVITGDTTQIDLPRSKQSGLIEVQRILNHIPGIAFHAFSGSDVVRHPLVQKIIAAYDQFQNPIAQPHEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIA3</accession>
    <name>A0A139SIA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34305">
        <property type="protein sequence ID" value="KXU34305"/>
        <property type="gene ID" value="AXK12_07455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8587" checksum="AC03D2350AE106F5" modified="2016-05-11" version="1">MGVREKGAESNRAHSPPARVNFAARAQLTHGARTFFAQRQTNDWHRLRLLIFSRRRRFAAVAARSQLMLTQIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC0</accession>
    <name>A0A139SIC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SWIB/MDM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713049.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07570"/>
    <dbReference type="EnsemblBacteria" id="KXU34325">
        <property type="protein sequence ID" value="KXU34325"/>
        <property type="gene ID" value="AXK12_07570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SSF47592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIB/MDM2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="94" mass="10049" checksum="A4A63644D8D18043" modified="2016-05-11" version="1">MAKKTAPAPARKANAAFMKPVTPDAALAAVVGSAPLPRTELTKKLWDYIKKNGLQNPKAKTEIIADDKLKAVFNGKAKVTMFEMTKLVSGHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC7</accession>
    <name>A0A139SIC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34296">
        <property type="protein sequence ID" value="KXU34296"/>
        <property type="gene ID" value="AXK12_07390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="459" mass="51147" checksum="4F365ACD3F1F38CA" modified="2016-05-11" version="1">MREKLSRTVFSFGALVILAIAVVTSVIVALIPAKDPEGIPFWVMSTQIHRAYVPVIAEWNRKHPEKRFGMQLITDRAFERRMLSGFLAGTPVADLLELNDGTAPKAFLGPIDQVGFLDLTDRIHAEGLYEQFNEPSFSAFTSRGRIFGLPRSVHPVLLAYRADLVEAAGIDVSQIETWDDYFRIMRPLMADHDGNGRPDHYLLNLSENDTGLIISLLFQNDGLLFDENDALAFASPRNAHALATIVTWLTGPAQAAIDVPLFTAAGHRQRLEGIVIGMILPDWMLGSWKVENPQLAGKIKLMPLPAWERGGRRTTINGGTMIGINKRAEHIEQAWELAKHLYMSAELAEQSFRENSLITTVKALWSLPIYDEPEPYCGGQIVGRMYIDQAPHVPRKPSSPYAGLASEYVRNVTMALRAYAERTETYDVAALETEALRLLSEAQAALQKQIARNLFSQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE3</accession>
    <name>A0A139SIE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">AXK12_07670</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713084.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07670"/>
    <dbReference type="EnsemblBacteria" id="KXU34342">
        <property type="protein sequence ID" value="KXU34342"/>
        <property type="gene ID" value="AXK12_07670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="266"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="473"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KXU34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="600" mass="65572" checksum="F440B7A80035C2EC" modified="2016-05-11" version="1">MADNSEKTETTLHGIPASEGIACGQIFLFARNLVEVPIYVVDAAKRCDEEARFERALVQARQQISKIQAQVERNIGQEEARIFDAHLMVLEDQALIGETIREFETTGLNIAACFNRVSTRYIKAFGEIDDEYLRERASDLRDVAQRVLQNLLGQADTSLSKLAGERILVASDISPSDAAALDRSTALAVVTDSGSKTSHAVIVARSMKVPAIVGMHDLTRRVRNGDWAVVDGYAGLVILNPSEETRARYQKIKAHKKTLEAQLLTANREPALTADGVSVSLLANIERADEATLVSDYNAAGVGLYRSEYLFLDTGRIPTEEEQTLAYTRVAEALAPQPVTIRTLDLGGDKLIGGGGGGLQFFASHKEKEENPFLGFRAIRLCLEYTEMFKDQLRAILRASAHGNVRLMYPMISGAEELARANALLEQCKAELRTAGVPFDEALPVGAMIEIPSAAMTVDVLAQSCAFFSIGTNDLIQYLLAIDRVNDRIAHLYEPTHPAVLRTLRRVIDEAHAAKLPVSLCGEVGGDPVLAPLLIGLGIDSLSMTPPLIPAVRYVVRNLTMQQARELADRALALGDPKAIHALCLDFYRDHMSQAGCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE6</accession>
    <name>A0A139SIE6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07440"/>
    <dbReference type="EnsemblBacteria" id="KXU34303">
        <property type="protein sequence ID" value="KXU34303"/>
        <property type="gene ID" value="AXK12_07440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="737" mass="80360" checksum="8C3C51C62FCA761A" modified="2016-05-11" version="1">MDEETVILSPFEVSSAVVGRYQANDAATGGRIATNVLDTPGSITVLTSDFIEDIGGGRVLDVARYVAGVAESTIPNAQDRVYIRGFQGASALVDGFMTASDANYDHVAIERMEVTKGPDAVLQPAGIPGGSINLVTKKPQWDFSGSLKLKLGEYDSNRIETDVTGPINSALAYRLVMAGQDSKSYMRNSYRDSLFINPSLAWRISPGSQLVLRYEHYDFKTSNLEGVIIDPMVGTDDKFRIFPGMPTDFNPEPSKEFSYRSNRFNTGTMLLTSVITDRLSVRLSGRLQHIQGGGADFRYGLLDENGDITNGGSRNPFTGKWEGGVLWVNTSSDPANPNWVPTSATQPTGTFRHEGGYSKTETWYRDLQNDWAYVVDSDFVKSSTLVGFSYRYSHGNGQSGGQTLPDFTIDNVPGGPVTTGPFTGDGRSITTSYQTYITETLEFFNNRLILSGGVAHMSFSASNQNKLSEAITTGPFPVPAAMNYPGSGSKATYNYGVVVKPTENLSLYYGHTENAVPSGDARSIYEGADPFTRGEQDDIGLKLRLFDGKIFATIAYYEITQENYAIWNPLNSEVPPPPVFLPNLLVDREAKGWEFQVVGSITPQLSFIVSYADTKNRDPNGIMLRGAAEDSAAGFVRYEFGPGPLKGLSAGIGANWLSKRALDTATGLTPTGVPNQPSAYISPRTLVDAHVAYERGPWSVRVDVTNLTDELDFIPLARNIVWPVNPRAFSGSVTWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SII1</accession>
    <name>A0A139SII1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">AXK12_07690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713090.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07690"/>
    <dbReference type="EnsemblBacteria" id="KXU34346">
        <property type="protein sequence ID" value="KXU34346"/>
        <property type="gene ID" value="AXK12_07690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="11"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="19512" checksum="D3A50D7B0953C8F2" modified="2016-05-11" version="1">MSRPSTTTPLRIGHGYDIHRLVKLDGTSPRPDAAPPRRLVLGGVVFESDCVLDGHSDADVLTHAICDALLGAAGLPDIGHFFPNTDPAFKGIDSQKLLEKTCAELRRRSWEIVNIDTSLVAEKPKIAPALAAMKARLAESANIDADRIGIKATTNEGVDDIGRGLAITAHAVALIEKRQIPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIJ2</accession>
    <name>A0A139SIJ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Colanic acid biosynthesis glycosyltransferase WcaL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713029.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07510"/>
    <dbReference type="EnsemblBacteria" id="KXU34314">
        <property type="protein sequence ID" value="KXU34314"/>
        <property type="gene ID" value="AXK12_07510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="403" mass="44901" checksum="73F668C37213B28E" modified="2016-05-11" version="1">MSSEEPTIAYLFTTFPKPTETFLQREVTAMLARGARLRLYSLWGGGGDFLGVPVEHFPKWKLLMLLWMIPYEAVRCPRVLWEVVRGLFTRLAPSWINFWENMLGAGFACLHARSFRKNPPALVHAPWGGAPATAAWLIWRLGGPRYSAAAHAYDIYEHGGDWWLVEKLAHAHFVHTSTEMGQRELIRRGVDAAKVICIRRGLDAMPQFKPLRAERTPLRLVCVARLVEKKGLRHQLQVYAALRAAGIAFQARIIGEGPLGEELERLAAQLGIADAVDFTGHLEHALVWKYLEWADVLLHTGMVAPSGDRDGLPNVIPEAMSVGTLVVSSLAAATTEAIKDGETGLVAAVRDTESWLAALNRLRSDDALAESLRANARRWVEENFNAHKNAEKLFTHFEGAIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIK3</accession>
    <name>A0A139SIK3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712881.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00380"/>
    <dbReference type="EnsemblBacteria" id="KXU34408">
        <property type="protein sequence ID" value="KXU34408"/>
        <property type="gene ID" value="AXK12_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="34070" checksum="00508D90AE6FC12B" modified="2016-05-11" version="1">MNPPPAAIFPPELREALYPFVSHWFTTPSGARMHYLDEGPEGDGTTCDEAVLMLHGNPTWSFYYAQLVKAVSPKLRCIAADHIGMGLSEKPQNYDYHLKTRIDDIAALVATLGLRRVHLVVHDWGGAIGFGFAARHPELIGRIVILNTAAFRSKWIPARIALCKLPVIGPAIVRGLNGFARPALAMSMSRRALSGDERRALIFPYNSWANRVAVSGFVRDIPMSAAHPSWDTLSEVEAGLAQFQKTPVLILWGGRDFCFNKRFYDEWRARLPNAEASFYKDAGHYVLLDAAEQVIPKISEFLTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIL3</accession>
    <name>A0A139SIL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="15" type="ORF">AXK12_00450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712901.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00450"/>
    <dbReference type="EnsemblBacteria" id="KXU34418">
        <property type="protein sequence ID" value="KXU34418"/>
        <property type="gene ID" value="AXK12_00450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="35072" checksum="0D4B363B2F692C34" modified="2016-05-11" version="1">MNFTVIGAGAWGTAFAIHLARSGAHSVSLVPRRAEHAAALVAARENEDYLPGIALPKTLGVTVELVSALAQAEVLLLACPSQALRETCGRVRAALPENSTAPLVLSLSKGLELHSHKRPSEVIAECLPECAVGALTGPTNAAEVARGQPAAMLLASTLGEEPLRSVQAALSSVALRVYTSGDLVGAELGACLKNSYAIAAGCCDGLRLGDNARAALLTRALAEMIRVGVALGARPETFYGLSGFGDLVATCHGAWSRNRQFGEQVGAGARATELLAGRRSVVEGYKTTQSFAELCAEQGIEAPILREVHAILFRDKPPAEALASLMTRELKEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP5</accession>
    <name>A0A139SIP5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712922.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00505"/>
    <dbReference type="EnsemblBacteria" id="KXU34427">
        <property type="protein sequence ID" value="KXU34427"/>
        <property type="gene ID" value="AXK12_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299268" evidence="1">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="228" mass="24710" checksum="8118F88405D786DB" modified="2016-05-11" version="1">MKLRYLLSSLLLGTLAAAQAAHAHGFWIEPRYGRLEAVFGHGPAVEAYPTDHLFAAWAYAPDGSPIRVDIQRTETHALLVPRQNEAAVVLASLDAKFFRPEDSATKNIKNAFIVLREGARLDQIKDIRLVLVPEVDPLKVGPGNPLPIRVYVDGKPAAGVRIMADYRGVGTTAFESAATTDAEGRASIIVRNAGLNVLAGFIAETDENGEQTFLHTTLAFLGLPYEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIY0</accession>
    <name>A0A139SIY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="8" type="ORF">AXK12_07240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07240"/>
    <dbReference type="EnsemblBacteria" id="KXU34538">
        <property type="protein sequence ID" value="KXU34538"/>
        <property type="gene ID" value="AXK12_07240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="333" mass="36408" checksum="1613C2902E43F598" modified="2016-05-11" version="1">MSHQPVLLREVLALLAKHTAASGAADADADLDVEPTFLDCTFGGGGHSRAILQTFPTSRLVALDRDPSASLRAAQLGETFGDRFALIDSDFGRLAALRDEGRQGRLPSFPRRAPSGFCGILFDLGLSSFQLDEVERGFSFRYDAPADMRMDPRKGVSAAQWLEDASEAELVRAIRDYGEEPCWRRVVAALLAARGTGALARTQSLAETIAAAIPARLRHTMKLHPATRAFQGIRIAVNDELGALERALPVAFELLAAGGVLAVISFHSLEDRPVKHFFRRLCGQPVDARDARPQDLRPRYAEPLTRRPITPSEPELAANPRSRSAKLRAIRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ72</accession>
    <name>A0A139SJ72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712852.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07275"/>
    <dbReference type="EnsemblBacteria" id="KXU34544">
        <property type="protein sequence ID" value="KXU34544"/>
        <property type="gene ID" value="AXK12_07275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299263" evidence="2">
        <location>
            <begin position="29"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="328" mass="32885" checksum="B3F13C1E9B58FA21" modified="2016-05-11" version="1">MKLLKLFGIVAGLHAAALVLIFANPGCSATSRGPRPNSNNTALGSADTPVVSVPYIVADQSGDPASTQLNAFGGDAGLSGEGAVPLFVNEDAQPDAAAGRARPTRPRTAVSAPLNAPPEVGDVTPATTYTVVRGDSLWTIAKRNKVTVAELAAVNKMAQGAPLQVGRKLIIPGKSSSSSAATATTPAATTAAKSAPAAATATEPKASLVHVVRSGETLGGIARRYQVRVGDIALANNIADPAKIRLGQTLVIPGGRVSTTVAAPRPAQTPVAKAEPAAPTPPSAAQIESTPALSIEAPEIIAAPPIDSPLDDGFGAVPADAPVIDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ3</accession>
    <name>A0A139SJQ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">AXK12_06890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712710.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06890"/>
    <dbReference type="EnsemblBacteria" id="KXU34808">
        <property type="protein sequence ID" value="KXU34808"/>
        <property type="gene ID" value="AXK12_06890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="20665" checksum="86E003B39ED14B72" modified="2016-05-11" version="1">MRHKKHRATLGVTREHREAMLSNMTASLITHGRIKTTLTKAKALRPFAEKLITKAKRAAAKTDPKDALHLRRLAHRDLRDENALTLLFNDKVNEFKDRNGGYTRIYKLGPRLGDAAEMALIELVKADDPGYKKRGSRGKAAASKAKKTAKPAAAAAEVKDAEPAVEAPAAAETPAPEAAVEAPAASEAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJQ4</accession>
    <name>A0A139SJQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">AXK12_06855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712698.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06855"/>
    <dbReference type="EnsemblBacteria" id="KXU34802">
        <property type="protein sequence ID" value="KXU34802"/>
        <property type="gene ID" value="AXK12_06855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="15632" checksum="39DE3F7B75E149F3" modified="2016-05-11" version="1">MKLHELSNVAGAVHRKKRVGCGEGGGHGKTSGRGGKGQTARSGGSIRPGFEGGQMPLYRRLPHRGFNNKNFRTELPIVNLGDLEALDAAISEVDAAVLAANGFLRKSDAKFKVLGNGELTRPLKITAAKFSESAKAKLEKLGGQAIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX5</accession>
    <name>A0A139SJX5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="6" type="ORF">AXK12_06415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712533.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06415"/>
    <dbReference type="EnsemblBacteria" id="KXU34869">
        <property type="protein sequence ID" value="KXU34869"/>
        <property type="gene ID" value="AXK12_06415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="65" mass="8160" checksum="B8B13CE270826B04" modified="2016-05-11" version="1">MPIEIKIRKNEPIDRAIRRMKKKLDRENIIKGVRANRYYEKPCERRRRKNKVQAFTQMLRRRYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY7</accession>
    <name>A0A139SJY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">AXK12_06840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712694.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06840"/>
    <dbReference type="EnsemblBacteria" id="KXU34800">
        <property type="protein sequence ID" value="KXU34800"/>
        <property type="gene ID" value="AXK12_06840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="178" mass="18873" checksum="169460ABB3570E12" modified="2016-05-11" version="1">MSRIGKQPVPVPANVKVAIEGTTVSAEGPKGKISKTFAPVITITQAEGQIVVAPADESRFARAMFGTARSIIAGMVQGVSQGFVKDLEIQGVGFRATLKGKQLDLALGYSHPIVMDIPEGITVTVADQTKVKVEGADKQLVGAVTAEIRSYYPPEPYKGKGVRIVGERVRRKEGKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ7</accession>
    <name>A0A139SJZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712576.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34889">
        <property type="protein sequence ID" value="KXU34889"/>
        <property type="gene ID" value="AXK12_06550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299296" evidence="1">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="41522" checksum="D75446A0C7588933" modified="2016-05-11" version="1">MKRFLPTITLLAAAALAPCAALAQSASNTEPARPESELPNFDFGDLHVEQKFNMSVGFRAVSGPKVTFSGHGNTVGDLSQALDPSITDQARQYNDGFVGLDQREGNPADGKTNTWGMVDAKQLVNGGQDVAMHLYSAEVTDGGTHQSKQGSDFGAELLVTRDMGHIGKRLQWQLFAGFSVNSVSGAARDSVTASLTTVRDLYSLAGQTLPSGPPYNAPSSIVDPNDAEKTIDTTVLLGRAPDSQGIDIGVGDSQVFNAWKLKGTYVSFRAGPTLLYDISEKIKLSISAGPVLMYSGTTYNVETLFLLDTGGEIVTRMEDSDSKVLTGYYGDVTLHYMITERAGFYAGAFFQSGESYNHDLEDGDTAYSAHIDLESLNGFRAGLQYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK02</accession>
    <name>A0A139SK02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712722.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06930"/>
    <dbReference type="EnsemblBacteria" id="KXU34814">
        <property type="protein sequence ID" value="KXU34814"/>
        <property type="gene ID" value="AXK12_06930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="391" mass="42933" checksum="BFA204EA9420F705" modified="2016-05-11" version="1">MIERATEAEVKRALGKNAAVGLLGPRQVGKTTLAEAIARAFEPTPIYLDLESPEDLAKLGDPGAYFRANEGRLIILDEVQRAPELFAVLRGVIDRRRRRGLRTAQFLILGSASLDLLRQSSESLAGRIAYTELTGLTAEEIGGGAQPRLSELWLRGGFPDSFLAGDDRDSLDWRRDFIRTYLERDVPQLGPRIPATVLRRLWTMLAHLQGGQLNTAQLGGSLGLSAPTARRYVELLEDLLLVRMLRPWSRNVGKRLVKSPKVYLRDSGLTHALLGLETLDDLLGHPVAGPSWEGFVIENLLSCLPKSAEAWFYRTAAGAEIDLVIQRGQAVTAIEIKRSSAPTVSKGFYLGCADIGASARFVVYPGEERFPLGKDTEAISLVELMALLHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK25</accession>
    <name>A0A139SK25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712580.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06575"/>
    <dbReference type="EnsemblBacteria" id="KXU34893">
        <property type="protein sequence ID" value="KXU34893"/>
        <property type="gene ID" value="AXK12_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="40902" checksum="7F0EFB110D685F8A" modified="2016-05-11" version="1">MSPQKLTNDDAAARSATATLRQTKGPARLYVGTYTGSGSEGIYTLQIDRLSGALAVPEVAAKTANPTWLIVSPDKRRLYAVSGGDAAAAAYAVDRVSGRLTPASEAYLGDGKPPCHLAIDATAQLLIASHYHHGTVTTIPIQAGGNWPASHGGTLGSPTRVIEHSRLGHPTGPHPTRQDAPHVHSATISPDNRYAYICDLGLDRIYAYALDSEHATLSPAPSFYTATRPGAGPRHATFSRDGRLLLVVGELDSTLTTYTYNSETAALTLVDTQSLLPANFSGENTAAEVRIHPNGRWVYASNRGHDSIATFALDDTRGQLRLLGHTPSGGRSPRHFAICPCGGWLVTANQESNTLCAFAIDQTTGLPSSTPTSTVTVPKPVCVVFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK68</accession>
    <name>A0A139SK68_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712477.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34968">
        <property type="protein sequence ID" value="KXU34968"/>
        <property type="gene ID" value="AXK12_06265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="765" mass="81473" checksum="4E119A7D3BBFE711" modified="2016-05-11" version="1">MPSAAVAASATPLRTPAHAWTFFRTGGIDQVALGSGEDLRHLAELDQKLWVALSCPVKGLEIDEQTLALIDSDEDGRIRAPELIAAVNWACARLKDAGDLLAGADRLALDAIDTSTPEGAILESSARQILRSLGKSKDSAITTADAANTAAIFSASVLNGSGVIPPAAAEEPAVQALIKDIITCLGGTASRNGATGVTAAQIDTFFKDLAAYASWVEQSGTKEIAVLGDATAEACSAIKLLRSKVEDYFARCRMAAFDPRAIEALNRSESEYLARAAEDMRLSAAEIAEFPLARIDETQRLPLLSGVNPAWGEALAHLHECAVTPIFGAEQTSLSVEEWRTLNAKLAPYETWQGDKVGSAVEKLGLPRAKEILASEGRAALAALVAKDKTLEPEFRAISDVERLARYHRDLRDLLHNFINFADFFDRARPAIFQAGTLFLDSRSCDLCIRVDDPAKHATLAAMSKAYIAYVDCVRPGGERVQIAACFTQGDSDYLFVGRHGIFYDRKGRDWDATITRLIDNPISVRQAFWAPYKKFVRFIEEQVAKRAAAADSEATSKLENVATNTVSTVASGKPAAAGGAVGALAAAGGGRPKFEVGTVAALGVGLGAIGTLLGGLVAGFLGLGVWMPLGILGIVLAISGPSMLIAWIKLRQRNLGPILDANGWAINGRVKISVPFGTALTDQAKLPKNARRMMRDPYAQRSKSLRHWLGAALVLVVLGAVATQVDRQRRGHYFWQSAPVVEVAEEASALPISDGEAGVEAGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK85</accession>
    <name>A0A139SK85_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">AXK12_06615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712590.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06615"/>
    <dbReference type="EnsemblBacteria" id="KXU34900">
        <property type="protein sequence ID" value="KXU34900"/>
        <property type="gene ID" value="AXK12_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="127" mass="13221" checksum="061251DB23AFFBCF" modified="2016-05-11" version="1">MNKLPSELRYAASHEWLKLLGDGTALVGITDYAQSALGDITYVQLPAVGTELAAGAGFGVVESVKAASDLYAPVGGVVVEVNPALDAAPETVNSDPYEAGWMLKLRLANPSEADALNDAAAYEKLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK89</accession>
    <name>A0A139SK89_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712581.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06585"/>
    <dbReference type="EnsemblBacteria" id="KXU34894">
        <property type="protein sequence ID" value="KXU34894"/>
        <property type="gene ID" value="AXK12_06585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="244" mass="25893" checksum="D0C69C44ECEC5D08" modified="2016-05-11" version="1">MTPTSETELPTKEKTAPVLVARDLHKTFTSGDRRLAVLRGASLSVSAGESISIRGESGAGKSTLLNLLAGLDTPDSGEVLWRSQSGSFGEPLVGGPSRLLKTRELGKLRGIIFQSFYLVPEIDALANVRLAGAICGLARGEAKARAHELLAQVGLSERTHHLPAQLSGGERQRVAIARALIAAPPLVLADEPTGNLDERTGDTIIDLLLGLCRERQTALLLVTHNPAHAAKCTRRLALHNGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA9</accession>
    <name>A0A139SKA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00170"/>
    <dbReference type="EnsemblBacteria" id="KXU35022">
        <property type="protein sequence ID" value="KXU35022"/>
        <property type="gene ID" value="AXK12_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="789" mass="84347" checksum="CD4F310DC9E327E2" modified="2016-05-11" version="1">MFALSGLGGGLPFAHAQLVVGDGEAEELTGRELVAALGSEPGQVRWSGSGGFATMQGETRITLNEMEWLIWGSADFVPDGRALVFGRPDSAGTIDWNSRIDLGGSNKKLPRQIRLVRGRLGDRANVVLRLRDALRSTVYEQSKSNWRLDFLGDGRFDILAAQPHLARGDIHVARAELRVAEAGQLNHVRKFVLSRGASFVVDEREAELDRLGAKADLKLDSSTFRYWGGGAAQPDASEHLGRVFLAGGVSTIEVINSSDGRSSVFLKSLARTGGSGAAKAARGVFEIHTRGNFVLSSEQVNPDFEGYGGILPWATINGEDWVARSGKDWVQVNSHYTANESSWEPGHNVTVREAQQLTTDRTINSLRAHGGSLNLGGHTLTVSSGGLIAVGPDFTFGSSDASGDYYRPSIITTGKTRNPLYVHVHTDNVWMQATLTGGMDLVKAGGGVLHLMHGYTGELGDVYMHEGRIEFAAKSKGTLQTGALYVGDGARTAALKLAGRERLSSRPHLSLRGSAHTPVDAGVLELSGATQQSFSRLHVENAAVIDYVDGSVGAENVLFVDELTFNSEAARLVIRHWVRNEDRLIVRRSANLSARAISQIDFEGWGNARLVDYDGDHWEIVSGPLSDSAAAIHAHPAAPLTPSLPEPAPSRASALGSSIYGATTPSPYGAAISDRAEYNSVESLPYVPPPVHEVVSHGVPSTRSPEPSALPYSSSSTSGFYQTPTPSPAAPTAPIGSLPELPAPSTSYGAGYQSSWPQTDIQAAPPPPPSAREIEEEIERILYETAYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKC3</accession>
    <name>A0A139SKC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712342.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00120"/>
    <dbReference type="EnsemblBacteria" id="KXU35013">
        <property type="protein sequence ID" value="KXU35013"/>
        <property type="gene ID" value="AXK12_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="2">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="397" mass="43123" checksum="617CBA29835EADE4" modified="2016-05-11" version="1">MASEKPFTFICGSDDFLVDRLGKERFAAMVGDSQDEFAREVLSGFANNVDEVRASIYRLRDSVQTVSMFGGGERRVVWLKDVNFLADSVTGRADSTLALLDEFREILAAINPQETALLITAAPVDRRRAFPKWCEKTAHFTLIDDKEDGGEAALLGVIRSEAAALGVSITPDASALLLARIGSNTRLIVEELHKLANFVEAGSDSDDETAESHASGQNAHTGSANTVTIEEAHVAELTPNVAEGEFFETAEAFFSGDLQWTLAALRRHFFAGGDARPILAALQNRNRLLIQIRTLIDAGDAQLGQRGLEGLPAAKSRYAAKFIGASEKNSFNLFSQHPFYVGKLASAGSGPGRAGGLPSLRRLIDNQQEFITAFEETISRPREQEQVLGEMVTRCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD4</accession>
    <name>A0A139SKD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34960">
        <property type="protein sequence ID" value="KXU34960"/>
        <property type="gene ID" value="AXK12_06220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="79" mass="9063" checksum="BE5344CCA55973C1" modified="2016-05-11" version="1">MFRVWRATGSDRCTVFHRHVISIRLPHGSPLAWENLWDFSTASSPPAKPNRQPPKPLQNQNQTPPKLLRQPVQSLQAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF6</accession>
    <name>A0A139SKF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_00335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712410.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35048">
        <property type="protein sequence ID" value="KXU35048"/>
        <property type="gene ID" value="AXK12_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="60"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="238"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="430" mass="47604" checksum="8E4A6F79F589D1EF" modified="2016-05-11" version="1">MSRLIFVNRFYWPEEPATSQLLTDLAQALANKTESESPPRQNEQSSTLKRDAKGRPTSPEVLILTSRRQGLARRETHKNVRITRLGSARRDSPSLVSRAFDLACFLLATLRYLARHTQRGDTVALLTDPPLLGLFATPLLRLRRARIIHWVQDIYPEIAAELSGQRWLRVLRPLRDWSWRKAHATVTLGPDMAAVLSAARVAPDRIHTIPNWPLPELSEAPPAEVAALKATWPASLADKFIVLYSGNLGRVHDLPPILEIAAALRDTAPHIAIVFVGRGAQQTPLRDAAHARALTNIHFLPPAPRAQLSASLSAGDLHLVTLKPGCEHYVLPSKLYGITAVARPLLFIGPRSCALFKEVTDTGIGLSFARDETSAAAKAIRALADSPDQRQRMQTATRTFSQIHTFSTSLHAWRRLLPDSEPLGANKHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ6</accession>
    <name>A0A139SKZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712184.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05805"/>
    <dbReference type="EnsemblBacteria" id="KXU35216">
        <property type="protein sequence ID" value="KXU35216"/>
        <property type="gene ID" value="AXK12_05805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="272" mass="28754" checksum="CDD0DC0220314B0A" modified="2016-05-11" version="1">MPRPANAPESTLEPLLTLAHELGREARNLAILGEGNVSMRRSQSALSETRAGEEAGRTFFVKASGSCLATLGAEGVAECRACELIAALDSRAMSDAEVEAALLGSRVAGDAARKPSVEAMFHAWLLTLPGVNFVGHTHPVAVNAILCSERARDFAAYRCFPDEIVCCGAASVLVPYVDPGLKLAQAIRRDVLAFIEKNGRAPRVILLENHGLIALGATAPAVLAATLMATKAAEIFLAAAALGGPRFLKPEQVARIAGRPDEHYREKVLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL10</accession>
    <name>A0A139SL10_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712214.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05855"/>
    <dbReference type="EnsemblBacteria" id="KXU35225">
        <property type="protein sequence ID" value="KXU35225"/>
        <property type="gene ID" value="AXK12_05855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="179" mass="18932" checksum="0B604120826D6EBC" modified="2016-05-11" version="1">MHSELELARELQRLLLHDGATLAVAESLTCGRMQEAIGAVSGVSPFFLGGVTAYSGEQKVRLLGVSRVEGEAVNWVSAAVAEQMARGAAQLFGSDFALATTGYAEPAPEQGVPVPFAWWALAQRVRGSSEDGVGDDNASAELFVRSERVECPGCLRVEVQRAVMAAALIGLCEHLRTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL27</accession>
    <name>A0A139SL27_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">birA</name>
        <name evidence="4" type="ORF">AXK12_06035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712277.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06035"/>
    <dbReference type="EnsemblBacteria" id="KXU35256">
        <property type="protein sequence ID" value="KXU35256"/>
        <property type="gene ID" value="AXK12_06035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="85"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="350" mass="39027" checksum="888B0BFDB7164F32" modified="2016-05-11" version="1">MPRRHHDSDSPELVILHELLTASPDYLSGQSLARTLGMSRVAVWQHMEKLRAQGFEFEAKHARGYRIAATPLELHPTYIEHLLRSHGRDALPFSVHDSVDSTNDEATRQLARGAPVPFVILAREQTQGRGRFKRRWQSGKHGNLYSSFVFRPELPPQRMPTFTLWLGVSICELIHTLLGLPARIKWPNDLVFGNRKCGGILTEARIDADQMRDLVFGLGLNVNQAAGTWADSDLRRPATSLRIEAGRTIDINHLTAALIGRIHLAYTQFIADDYRPQLTELWAKHDALHGQKVVVLNGTQRIEGTASGIDESGNLLLRPSTQVGEAEAPLLRFAAGEVTLETAEPRTANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL38</accession>
    <name>A0A139SL38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712310.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06125"/>
    <dbReference type="EnsemblBacteria" id="KXU35272">
        <property type="protein sequence ID" value="KXU35272"/>
        <property type="gene ID" value="AXK12_06125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="116" mass="12939" checksum="6D26A0312404EF22" modified="2016-05-11" version="1">MSTESQPAAHGGDHHAAEDNKFQIYVKIAMLLAVITGIEIVIIFFPWAKWLIVTSLVVLSVVKFLYVIFYFMHLRWDKAFCTVLFFIGMIMAGGTVWALMAIFGAADSVPLTSLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL39</accession>
    <name>A0A139SL39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome c oxidase polypeptide II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">AXK12_06110</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712304.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06110"/>
    <dbReference type="EnsemblBacteria" id="KXU35269">
        <property type="protein sequence ID" value="KXU35269"/>
        <property type="gene ID" value="AXK12_06110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04213">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034236">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="21">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="20">
        <location>
            <begin position="143"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="22">
        <location>
            <begin position="325"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KXU35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="423" mass="47193" checksum="DEADA7DCA99546D6" modified="2016-05-11" version="1">MRTPSSLSFLKKTVAASRAACVLAAVFLLAGCSQLNFWQMDGHQTSMVTAGPVAESQLQVFYATVWVTAIIFVVVAAVLTYATIKFKARTTDDENAPPPEQSHGNPLIELSLIGVSVLALVFIAFPTLRAIWFTYDVPEEERENAYVIDAIGYQWWFKFDYPMEQIDGVGALSVANEMVIPAGRPVRVNLRTVDVIHSFWVPKLAGKVDMTPNRGNHMWLQADEPGYFWGQCAEYCGDSHAVMRFRVIALNEADFAEWVAHKKLPARTVTPEIADPARAERPQITFASFKRNEYGFSDKWDPRSQVSPLDNWRQQQFPHEGEDAALIAQGRKLFQTKTCIACHTVRGHEGMGITGPELTHIASQTTIAAGLLENTPEQMARWIMHPEVVKPGNKMYTTGYVPSEITIDQDEALALVAYLQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL43</accession>
    <name>A0A139SL43_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">AXK12_05915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712336.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05915"/>
    <dbReference type="EnsemblBacteria" id="KXU35282">
        <property type="protein sequence ID" value="KXU35282"/>
        <property type="gene ID" value="AXK12_05915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="278" mass="30346" checksum="69A05C5811BE342D" modified="2016-05-11" version="1">MPTEWTPVKSYSDIRYEKCAEGIAKITINRPEKRNAFRPETVAQLFEAFSDAREDQRVGVVLLTGAGPHTDGKYAFCAGGDQSVRGPAGYVGGDGVPRLNVLDLQKLIRSMPKVVIALVAGYAIGGGHVLHLVCDLTIAADNGIFGQVGPKMGSFDGGFGASYLARIVGQKKAREIWFLCRQYDAQQALDMGLVNAVVPIADLEEEGIKWGREIMQQSPLAIRCLKSAFNADVDGQSGLQELAGNATLLYYMSEEAREFHQAQREKRPPDASKFPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL44</accession>
    <name>A0A139SL44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05985"/>
    <dbReference type="EnsemblBacteria" id="KXU35247">
        <property type="protein sequence ID" value="KXU35247"/>
        <property type="gene ID" value="AXK12_05985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="96" mass="11466" checksum="BA171830D79F74FC" modified="2016-05-11" version="1">MVKVTTGLLIYDTQCSSKFFKQDIAKTIFNEKFISNYLFYVELFLRLKREFGEAIFLEKTHELSLTRWKDISASKVKPIDFLKAPIELYKILKDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL50</accession>
    <name>A0A139SL50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_05865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712332.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05865"/>
    <dbReference type="EnsemblBacteria" id="KXU35281">
        <property type="protein sequence ID" value="KXU35281"/>
        <property type="gene ID" value="AXK12_05865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="160" mass="17058" checksum="DB6F59356D7704B4" modified="2016-05-11" version="1">MQPANVVTLHYTLRDPEGRVIDSSSGGEPITYLEGAGQVIDGLDEALRGVAAGSRQRVSVPAARAYGAHDPSQVQRLPRAQIPFAGDINVGDRFQTDTDPHAPVVTVVAADEESVTLDANHPLAGMDLDFDVEVLAVREATSEELRHGHAHGRDGQAHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE1</accession>
    <name>A0A139SLE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">AXK12_05195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05195"/>
    <dbReference type="EnsemblBacteria" id="KXU35369">
        <property type="protein sequence ID" value="KXU35369"/>
        <property type="gene ID" value="AXK12_05195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="6"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="425" mass="45188" checksum="9E8916FCB483DB4F" modified="2016-05-11" version="1">MPAPLEAQILEIAQNARAASLALATVPTDAKNAALHELARLLETHSDALLAANARDLAAATENGLTHAQIDRLTLTTDRLAKLAQSVREVAALPDPVGELLDETTRPNGLHLRRVRVPIGVIAIVYEARPNVTIDCAILCLKSGNAAILRGGKECFHTNTAFAALITRALATSGLPPAAAQLIPTTDRSALTHLLRLDALVHCIIPRGGESLIRFVSENSTIPVIKHYNGICFVTIDQAANLDMAEQIIVNAKTSRPGVCNAAEQLLVHRAIAETFLPRAAQALIKAANVELRCDPASAAILASANIPHTAATEADYRTEFLAQTLAIRIVDSLEDAIATINRDSSGHTETIVTADKAAAEKFLAAVDSAAVLWNASTRFSDGYEFGLGAEIGISTDRLHARGPMGLRELCTYKWIGTGTGQIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF0</accession>
    <name>A0A139SLF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711966.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05255"/>
    <dbReference type="EnsemblBacteria" id="KXU35379">
        <property type="protein sequence ID" value="KXU35379"/>
        <property type="gene ID" value="AXK12_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="86"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="535" mass="59165" checksum="672335A8197E5BB1" modified="2016-05-11" version="1">MSDCARSAKRFRAWASLLALLGLVGCKPRETAVEIATRSGTLLLGNAAEPSDLDPHLASTLTGQVIINSLFEGLTVLDEASMSPLPAAAESWEVSPDGLTWTFQLRPGLHWSNGDSLTAADFVRSWQRALTPALAAYNAWYLFVLKNAAAYNAGELDNPDEIGASAPDALTLILTLEHPAPYLPALLSLPAWFPLHSGNLEKFGALTQRGRPWTRPGELVSNGPYTLAAWEPNARIVLEKNPQHRDASQTQIERIVFLPIENADDEERAYRAGQLHATFTLPVTKVATWQKNASSELHIDPILQSYFLRINAAAHPALADASTRRALSRSIDRDLLARSVLQASRSPATSLVPPIDDYRPATIQSEVAAHENRSGSLPPKLELIVRNDALMPRVAEALQAMWKTQLGIEVSITQLEQKTWVQRQQTGDYQLCLSAWTADYPDPLSFLELFLSDSPYNWTGWASRDYDTLLTRAAHTSNPTARFTLLREAETLLLEEAPIAPLYFGAETRLVHPSIRNWTPAPLGFRRFQLLQFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH6</accession>
    <name>A0A139SLH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35405">
        <property type="protein sequence ID" value="KXU35405"/>
        <property type="gene ID" value="AXK12_05405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="247" mass="27320" checksum="B57D469E5BF69FAF" modified="2016-05-11" version="1">MVLDGDTEYSLLINSRIRDNGHKVGLRISSEGEKKQVIMGGGSGNTFTGDVELSNTYLGLRKGDGVVAIKGNVFVNRSAILTFDSSHQLDRSSVVALKGGRLRFGSWGGDVTQSFKQLTVDSFGIISFGHENKPTAIKKLYLDDLLVRSSGELRVVGWAEGRDFILVKKTSKNLEAALKKMKFEGYDPSKIHLEDYNSEYWMINGAPEPATYGAGLMLAVLGLVRYRRRQKQRFPLRVGRRSVTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLN1</accession>
    <name>A0A139SLN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711995.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05340"/>
    <dbReference type="EnsemblBacteria" id="KXU35394">
        <property type="protein sequence ID" value="KXU35394"/>
        <property type="gene ID" value="AXK12_05340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="166" mass="17894" checksum="011464B9EC003BF9" modified="2016-05-11" version="1">MQPENPKLLTLEDAVEARAALRRTGRRLVLTNGVFDLLHPGHLYSLAAARALGDALFVAINSDASVRALKGPTRPILSETERAYALGALECVSGIVVFNTERLTAEIRALAPDVYAKAGDYTLETLNPEERAALEACGADIQFLPFWEGFSTTALIQKIRESGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLR8</accession>
    <name>A0A139SLR8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ANAPC4_WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711919.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05115"/>
    <dbReference type="EnsemblBacteria" id="KXU35503">
        <property type="protein sequence ID" value="KXU35503"/>
        <property type="gene ID" value="AXK12_05115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ANAPC4_WD40" evidence="2">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="372" mass="38956" checksum="CCE77BA71ECA5CE0" modified="2016-05-11" version="1">MELVKHWAAQLDDYVIDLAWSPDGERLGVASAAGPISLYAVSTGALLHTAPGHADGTNCLAWQPSAKTQLLVSGGQEPRIKFWDAISGQHCATAELETGSGWCEHLAWKPALADSAETDEAAANGAAPRTGSPNKENCVLAAASGRQLYALRPDGSLAHRFAPAPKSLSALAWSPDGKTLAAAYYGGVQLWDGADFSLQKDLPYVGGIACLAWSPDGHWLVSGNHDPSVHLWRPAEDLELQMSGYSHKVNAIAFDARGRWLATSGGSDCCVWDCSGAGPEGRAPAMLPHDAKLCAVAFQNTHGLLAAASEEGTVKLWSVERALSSAGNTGGKPLRATVTMPAAATRLAWSPDDSLLAIGTTQGIVYTLKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS2</accession>
    <name>A0A139SLS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711915.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05105"/>
    <dbReference type="EnsemblBacteria" id="KXU35501">
        <property type="protein sequence ID" value="KXU35501"/>
        <property type="gene ID" value="AXK12_05105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="342" mass="38163" checksum="72C25C607A0036A0" modified="2016-05-11" version="1">MPTTLFTQNTVACIWDFDKTLIPGYMQAPLFQRHGVGEAAFWAETNALVENYRRRGYRLSGEISYLNHILTYVLAGKFGRLNNRLLREYGGEIAFYPGLPEFFDLAKTYAGEKPLYQKHEIALEHYVVSTGLAEMIRGSAIAPYVEDIWGCEFIESPLQPGFMSQGEIELGDDAVIAQIGMVIDNTTKTRALFEINKGTNKNPDIDVNSYLRPEDRRIPFQNMIYIADGPSDIPSFSVVKGGGGRCYGVYNPDHSGEFEQNDRLLQAGRIHGYGPADYTATSSTARWLRLHIHAICDRIVADREAAVAAKASRPPRHLTESPEEEAAKLRAKQAPQQASLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLT1</accession>
    <name>A0A139SLT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711929.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35507">
        <property type="protein sequence ID" value="KXU35507"/>
        <property type="gene ID" value="AXK12_05140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021647">
        <property type="entry name" value="CusF_Ec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042230">
        <property type="entry name" value="CusF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11604">
        <property type="entry name" value="CusF_Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299267" evidence="1">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="14007" checksum="D53C8282E8A8190E" modified="2016-05-11" version="1">MSSLTRLFLVFVFSFAGVFAASEPSGEKAEEGPLVKGVVTRRLDERRLVMVKHEEIPGVMRAMTMAFSVPDELWDKLEPGVYLRGRLGGGRGDWRLSDVELTDWRYEPLPEDEGKGEGTSETSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM49</accession>
    <name>A0A139SM49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711834.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04910"/>
    <dbReference type="EnsemblBacteria" id="KXU35656">
        <property type="protein sequence ID" value="KXU35656"/>
        <property type="gene ID" value="AXK12_04910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="35869" checksum="CBCFD9F67ED2A016" modified="2016-05-11" version="1">MLFSSSKRIRCGVAGVGSLGQHHARVYAELPDADLVGVYETSDARAAEICLKYGCRRFATLEELGSACDAVSVVVPTDRHAEVALPLLAQGTHLLIEKPLCASLDEAQRVLAAAQAHGCVVQVGHIEHFNPVMAFLEKQVRAPQYITAERLAPYQPRGTEVGVVLDLMIHDIGIVLALVKSPVRRIDSVGVTVLSKKEDIANARIEFESGCVANLSASRLSTKRQREIRLFQPDAYLSLDFMNQEGHLLKKSDLLAYGAKMKLGLVKTGDLSAIPVKSIPIEKGEPLALELAHFVKSVRLAQEPKVGAALGTRALEVAITITEQIQNARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM55</accession>
    <name>A0A139SM55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35615">
        <property type="protein sequence ID" value="KXU35615"/>
        <property type="gene ID" value="AXK12_05040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="71" mass="7415" checksum="A5AFEF26BCDAA6D1" modified="2016-05-11" version="1">MGSFSDFGFASARRAETKPKSKWVQRHAAAPRAVEKSVSARLAVETGADSSRVLIALLVTAGAASRSLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM73</accession>
    <name>A0A139SM73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_04720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04720"/>
    <dbReference type="EnsemblBacteria" id="KXU35673">
        <property type="protein sequence ID" value="KXU35673"/>
        <property type="gene ID" value="AXK12_04720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="53"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="330"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="733" mass="82030" checksum="FEC9D7F765199802" modified="2016-05-11" version="1">MLGLAVSSHAQQPPIQIDEDIIRLSPFTVQESANLGRYQAAQVSSGSRVRMDLMDSTQSVSVLTNEFLGDIDTTQMLDAVKYVAGVGISNNPEIMDIMNIRGFQNWRAVTIDGFSQAYGVINTDPIIIERIEVVKGPNAILAPQGLPGGVVNSVTKRPLFKNSGSVSYQVGRYDSNRAEIDANYVVKDDKLALRVVGAFTDADKYVKEKFFQNLTVIPMLTYRISPTTELTAQGHVYNGAAQGEPLPISVYAVGRSNVRILDGIPRDFGLTGRNISRHESGQRAQFFLTSQITDKLSMRLAAKWAETSTRVNGVNVSESRDASGARLVPVQLNNTTGVWEWDGVTRNDDPRFLLSGLQNGVTVDHANLQNDFVFEHNAQGWRSQTVGGYAINYTSRSGWNRNYVADPTLYNFKDPNYTPPTFTLESDWDYNNGTRDRSHQVYLYQVLHLFEDRLVLSGSLSQNRYFTGDYDNLSGGRSQEKAETTLPAAGLVYKLTPEISLYYGYSEQEIMGASQPVELIPSHTSPSRQHEVGLRLRLFDGRLYTTFAYFDIMQDGIWSQATENMIDPTAPKKTAQRSDRTSKGFEFEFAWSPTKNFSVIGSFTDFKSRDQDDLRYANVAERMAGIWGSYSFPEAGPLRGLSIGLGANYVGERPGDTMGSYVNILNPVRVQPAFWLPSYTEVEANATYRFNKHWKAQLVIKNLLDKEYIRGAFNRNAFVSTPINPKLTIRYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SME5</accession>
    <name>A0A139SME5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711830.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04895"/>
    <dbReference type="EnsemblBacteria" id="KXU35654">
        <property type="protein sequence ID" value="KXU35654"/>
        <property type="gene ID" value="AXK12_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1136" mass="119388" checksum="77A097A33ED027A2" modified="2016-05-11" version="1">MFGNVSGGPADPDEPLITVTNNADRELDSLWFDSAAGIFYTIGGTGTLTLGAGLADGGRLITVISNGGAHSETNINNGIVLDDMVSGRARWIVNHSQAGLRLSETVNLGSQQLRISGTGATHFSGSLSGTGKVSSISESQYATPHLILNANNSGWSGGLSVGVRTLVFVKADRALGTGATVVTQGGTLGFRSHGDGPSLDYSNPAGALSVRGFGAARQVGKLGIGAIYHDGGNNLFSGDITLAGSTYFGARGDSGGLTLSGAILGSGFFYKIGSGLITLTNPNSPARTISIDQGVLRITEQQHVAGAIRFAGAKLLYPDSSGILELSGNVNSLTLEIGTGAGRIQWRGAGGFSAFGGDRSVTLNAPGALVYWGRHGFVSHDRTLFLSSRYADSKITLNNSIELLGYNPIYVARGVSYGARAEISGALTGTNGWFHKVGPGRLDIIGTNTYRMPTDISEGVLVGHIPDASNLYLGGGVLGLESDFTRDMGSGAKQIRWEVGRSGGFAGYGGDHAVRLNGTTAQIDWETNHFVKAGDELRFGHYTADGTVLWDKQLGLGTDGHRTIRVERGLPAAAANRADVSFTQALSGTGGSLTLKGDGRLDLAVDNADLKLDEIRIHGAELRLQQAGRITAPGTHFILKNGGALVLDNLGTHNATTGGSYQADRLHDDSEITLTASTLRYQGSDAAPSEERVGTLILEAGASAIDVQSSGSATATLNASSLTKNLLATANLTLGTLAEFVLNSWAADYSINDGGGTAIAPWLTVNGKDWATPIPSGMATTLSALSTYESGDQGTWGTAHNIALTAAQTLGGARAINSLKLATTGALNLGNFTLTLNSGGLLSIAGGTLSGTGRVNTAVSRPLYVHVYGADLTLSGGIQLDVPRLVKTGGGRLTFNTSALHNLGRLHLHQGTVDLQQGRINASHIVVGDGAGKDSLILPANTWEPLANKPEVTLHGTPYGPGAEYASYNPDEAILRLSGNTKQHLTKLTITDRGTIDWSGGEVATANFLWIDELEFNNADARLFMRNWYEYEDYFLISRTWLNSRNEAQRAQLLSQIIFDGYQDFPVLAEGYDANYFMITPFNAPEPATYGAILGAVGIGLVAWRKRSRQQAKEREDVKRPRRQIKPPPAAPHAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMH9</accession>
    <name>A0A139SMH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metX</name>
        <name evidence="2" type="synonym">metXA</name>
        <name evidence="5" type="ORF">AXK12_04760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04760"/>
    <dbReference type="EnsemblBacteria" id="KXU35694">
        <property type="protein sequence ID" value="KXU35694"/>
        <property type="gene ID" value="AXK12_04760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="47"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="382" mass="42551" checksum="CC401AFD40BA144D" modified="2016-05-11" version="1">MRNDGVGIVTPRDFVCAEPFTFKSGQVLPGFTLRYETYGQLNAARDNAVLICHALSGDHHCAGRHSAADRKPGWWDHLIGPGRAVDTDRFFVICANCLGGCSGTTGPSSINPETGKSYGISFPFVTINDMVRSQKRLLEHLRVEKLHAVIGGSMGGMQALLWAILYPNFVRRVLAMATTAREGAQAIAFNEVGRQAIMQDPAWEAGNYPPDGGPRVGLAIARMMAHITYLSDASMERKFGRRKRAAAEAQDSYSFDIQFEVESYLRYQGQSFINRFDANSYLYITRALDHFDLAHAYGSLERAFAPVQAETLVVGFTSDWLFPPEQNREIVLTLLRAGKRASYAELATDRGHDSFLLESPDLYEIVRGFLEREDEFVLDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN65</accession>
    <name>A0A139SN65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711600.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36063">
        <property type="protein sequence ID" value="KXU36063"/>
        <property type="gene ID" value="AXK12_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="41083" checksum="DE28C1B93DC73C5D" modified="2016-05-11" version="1">MKVAPRLLTNLCYLAMMCLSIGLNLLPVFLTSLGVTYGGEAGLSQEEMGRLTASPFGGLVLGILAAGPLVDRWGAKRFVQIGNVLMAVSLLWAAFAPSYLSLAVALFGMGLGAGVLDMVLSPVVAALNPERRTVAMNWLHSFYCVGAVVTIALGTVALQAGLGWRGACLVMLVLPVGLIACFAPMKFPALVPEGEVVLSIRSLAREWWFWGAMLAISLGGAAELGIAQWLPAYAERSLGYAPWVGGMSLLLFSVTMTLGRMAVGWFGKNWDMYRMMAWACASSVVLFIAGSFLPIPWMALAACIAVGFTGSCLWPTMLGVTANRYPRGGASMYGLLSATGNVGGVFMPWAVGIVADRSNMHWGLVISVVAPLLMAPLVLVMRRHASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN99</accession>
    <name>A0A139SN99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_04305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711676.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04305"/>
    <dbReference type="EnsemblBacteria" id="KXU36103">
        <property type="protein sequence ID" value="KXU36103"/>
        <property type="gene ID" value="AXK12_04305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="34139" checksum="C66E49033D2972EB" modified="2016-05-11" version="1">MAADPIRFYNRYTQALETEQIFGERWLRFAYENPMGRAGLWLLARRKFFSAYYGWKMSRRRSQLRVLPFIAKYDLNVEEFAKSAFTYRSFNEFFYRTLKPECRPISEGAGVAVLPADGRHLVFPDVDAAAGFYVKGAKFSLVELFADASLAREFSGGAMLISRLCPVDYHRFHFPVSGSPGPARLIKGWLYSVSPIALRRNIGYLVQNKRMLTLMETEAFGRVAMFEVGATNVGSIRQSYVEGRAVARGEEKGLFAFGGSCVITIFQRGRIQFAPDLVAQSAVHIETYARMGDVLGTCASRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNC4</accession>
    <name>A0A139SNC4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_04630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04630"/>
    <dbReference type="EnsemblBacteria" id="KXU35982">
        <property type="protein sequence ID" value="KXU35982"/>
        <property type="gene ID" value="AXK12_04630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="276" mass="29901" checksum="5EE43C6BC0DBBCB5" modified="2016-05-11" version="1">MPNTKPDAAPTSASQTKRDESPVAVRIEGLSKSFGAHEVLRNVSLEVAPGEIFVLMGPSGSGKSVLLKHIVGLEAPSAGRVTVDGLDAADPATRHAVHMALVFQAGALFNSLSVYDNLALYLREHRLGTETQIREKVRHALKILSLENAERKSPAELSGGMRKRVAIARALVMEPQLMLYDEPTSELDPIMSATISEIIATLKTQTRVTTIVVSHDRDLALGIADRVGILMQGELLTIATPAELRRSTDPRISDFLNPQINLSSPRFKQLETAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND4</accession>
    <name>A0A139SND4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711607.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04395"/>
    <dbReference type="EnsemblBacteria" id="KXU36066">
        <property type="protein sequence ID" value="KXU36066"/>
        <property type="gene ID" value="AXK12_04395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="274" mass="30187" checksum="1208C90D040470FB" modified="2016-05-11" version="1">METAVPAPAPEFITSLQNSRIKLLVKLRDRRPRDAARIFLVEGYRQIRRALDKSIPLLELYFCRECFLGKNEDALLEEARAAGAELIELSKPAFEKVAYRERPDGLLAVAPQWRRRLSNLALSESPFVLVVEGIEKPGNLGTILRSADAAGCDAVIVCDPVTDIFNPNVVRASTGVLFSVPLVVAESREVAAWLRAKGIRTAATTPHSEQLYSQADLRGPIALIMGSEQYGLSDFWLQESDLTLRIPMAGQADSLNVAMATLVTLFEAVRQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH5</accession>
    <name>A0A139SNH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711556.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04255"/>
    <dbReference type="EnsemblBacteria" id="KXU36042">
        <property type="protein sequence ID" value="KXU36042"/>
        <property type="gene ID" value="AXK12_04255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="39726" checksum="C3B27A5075B072E1" modified="2016-05-11" version="1">MSLPIKPASACHFDQISLGEVMLRLDPGDGRIRTARHFTAWEGGGEYNTSRGLRKCFGLKTAVCTAFVDNEVGHLIEDFIAQGGVATDFIQWREDDGIGRSVRNGLNFTERGFGIRGAVGVPDRGNTAASKLRPGDFDWEHIFGKLGARWFHTGGIFAALSESTAALTIEAVKAAKKHGTIVSYDLNYRPSLWKTIGGLAKAQEVNREIARYVDVMIGNEEDFTASLGFEVRGADHAISKIEVDAFKEMIEAAVAEFPNFKVAATTLRRVITATKNDWSAILWHAGQFYRARQYAELEILDRVGGGDSFASGLQFGFLEFNDPQKAVDYGAAHGALASTTPGDTSMATRKEVEKQIAGGGARVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNL9</accession>
    <name>A0A139SNL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03955"/>
    <dbReference type="EnsemblBacteria" id="KXU36177">
        <property type="protein sequence ID" value="KXU36177"/>
        <property type="gene ID" value="AXK12_03955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="415" mass="45163" checksum="3ABCD33E8DFAFE64" modified="2016-05-11" version="1">MRPRRLAEVVGQEHITREGSLLPRLVAQDRFGSLIFYGPPGCGKTSLAESIAAESGGRFVRINAVMSNVAELRQLLAAARANPAARTILFIDELHRFNKSQQDLLLPDVEEGNVRLIGATTHNPGFYVNAPLLSRSHLFRLEPLSPAAIAGVMQRALADDERGLGKRRCTAQEDILLDLGALCEGDLRRALNALEVIVFGLDEGTAITAADLEVFARERRIRYDADEDEHYDTISAFIKSCRGCDPDAAMYWLAKMLAGGEDPRFVARRLVILASEDVGLADPMALPLAVAAQQAVDFIGLPEAELTLAHATLYIATAPKSNSATLALAAAHAALKRGPVQPVPLSLRDKSGKANKAAGHGQGYRYAHDYPEAISGQAFLEKPLTLYTPKRNGWEAKIADRLAHWAELKSQLRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS5</accession>
    <name>A0A139SNS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylcholine 1-acylhydrolase</fullName>
            <ecNumber evidence="8">3.1.1.32</ecNumber>
            <ecNumber evidence="9">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">AXK12_03570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer; dimerization is reversible, and the dimeric form is the active one.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="8"/>
    <dbReference type="EC" id="3.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03570"/>
    <dbReference type="EnsemblBacteria" id="KXU36229">
        <property type="protein sequence ID" value="KXU36229"/>
        <property type="gene ID" value="AXK12_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052740">
        <property type="term" value="F:1-acyl-2-lysophosphatidylserine acylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052739">
        <property type="term" value="F:phosphatidylserine 1-acylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003187">
        <property type="entry name" value="PLipase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036541">
        <property type="entry name" value="PLipase_A1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40457">
        <property type="entry name" value="PTHR40457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02253">
        <property type="entry name" value="PLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01486">
        <property type="entry name" value="PHPHLIPASEA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56931">
        <property type="entry name" value="SSF56931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299350" description="Phosphatidylcholine 1-acylhydrolase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KXU36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="309" mass="34374" checksum="2A52AF9683C8C96C" modified="2016-05-11" version="1">MSICRLVLTFLFLCAALGAKGQESAAGERVASAGQAVASSAVRLGSESGDSARKRTAEEAIRRAFEERFGLHEPIYFIYGNEPQGAKYQFSFKYRVLGDREPVGEDGAETLRRVFFGYTQRSLWDIDSLSSPFYDSSYMPELFFESTRTLDAQAISAADRFAFLGYQVGIKHESNGRAGADSRSLNTLQFRTAFVLGDLARWHGIVAPRLWAYVSDSSDNPDIRDYRGNVELQVAIQHGDGVALSATGRVGRKGRRGSVQLDLTVPIELKGRFNFASYLMVQYWSGYGESLLDYNKHSDALRFGFSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU3</accession>
    <name>A0A139SNU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711326.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03615"/>
    <dbReference type="EnsemblBacteria" id="KXU36236">
        <property type="protein sequence ID" value="KXU36236"/>
        <property type="gene ID" value="AXK12_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="116" mass="13041" checksum="D8CE60549389DAFB" modified="2016-05-11" version="1">MTQSATAPLEINVAQAHTILRETREAPALPLLIDVRETHELEIARIDTALHIPLRELPQKADTLPRDRPLLLLCHHGGRSRRATEYLRHLGFSNATNIVGGIDAWAEQIDPKLARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNV8</accession>
    <name>A0A139SNV8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB</name>
        <name evidence="3" type="ORF">AXK12_03995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711460.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03995"/>
    <dbReference type="EnsemblBacteria" id="KXU36184">
        <property type="protein sequence ID" value="KXU36184"/>
        <property type="gene ID" value="AXK12_03995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="17"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="263" mass="29341" checksum="866F41A1FA004D02" modified="2016-05-11" version="1">MEILIQPNPEAGCLLAAKIMARVVREKPTAVLGLATGRTPLQLYNELIRMHRDDGLDFSKVTTFNLDEYVGLPGTHPQSYRHFMDEHLFRHINIDRARTHVPDGTAADLQAECRSYEQRIADAGGIDIQLLGLGRNGHIGFNEPTGSLRSRTWVKILSEQTLRDNSEVFGSDERGMPKQAITMGVGTILDARQCLLLAFGPSKVRAVAHMIEGPLAAICPGSALQMHPRAIVLLDENSAAGLRYADHYRWIDQHKLDWQRHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNY5</accession>
    <name>A0A139SNY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03585"/>
    <dbReference type="EnsemblBacteria" id="KXU36232">
        <property type="protein sequence ID" value="KXU36232"/>
        <property type="gene ID" value="AXK12_03585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="3">
        <location>
            <begin position="67"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="491" mass="54310" checksum="C12C1BDE933EE3A7" modified="2016-05-11" version="1">MSAFSPSIASDDAPTSASQDKGVLAPNPVAGIDQTRGDFTYDVEYEYDAGVGLSEATVRYISQVKKEAPWLLDFRLKALKKFESMPLPTHWATKDLENIHFDKIRYYLAQGQKPKRTWDEVPDDIKETFERLGIPEQERKFLAGVEAQFDSEAAYSNIKSIVAKQGVIFVNSTEGLREHPELFRKFFGKVIPTGDNKFAALNSAVFSGGSFIYVPPGVKVAQPLQAYFRINAENFGQFERTLIIADEGAEVDYMEGCTAPKFSTSTLHSAVVELVALKGAKIRYITVQNWANNVFNLVTKRGLAHEEAEIKWIDCNIGSRLTMKYPGVILRGRKARGEVISIALANDGQHQDTGAKMVHAADETTSNIISKSISVGQGRATYRGLVQMGKGLKGCKNNTECDALLINTNSRTDTYPAITVRGDKHATQHEASVSKVSEELIFYMQQRGLTEAQAMSLSVNGFINDLASQFPMEYSVELKRLIDLEMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP07</accession>
    <name>A0A139SP07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_03655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711342.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03655"/>
    <dbReference type="EnsemblBacteria" id="KXU36244">
        <property type="protein sequence ID" value="KXU36244"/>
        <property type="gene ID" value="AXK12_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="629" mass="67164" checksum="A202EEAB783C7779" modified="2016-05-11" version="1">MTPVQNALLVLLVPLVSAALIALFLRRRGGLATTVSVTAAGALAALSLLLIFGGDAARFTTSVEWLRLGDFSLSLGFLFDDLAALMLFVVSFVGFFIHLFSVGYMHEDKARARYFGGLSIFMFSMLGIVLADNLFMIFIFWELVGFSSYLLINHYHEKQSAADASKKAFIANRVGDFGFLLGIILCYATYGTTNLVELRALGEAGALSATCASAIPLLLFCGALGKSAQMPLHVWLPDAMEGPTPVSALIHAATMVAAGIYMLCRVEVLMVAEALNVILWVGTITALYAALCAVVQRDIKKVLAYSTLSQIGYMVAAFGLGSTLVSPDGAPELVIAAGVGAAMFHLTTHAFFKALLFLGAGSVIHGCHHEQDMPKMGGLAKKMPVTYATFTLGVFAIIGMPGLAGFFSKDAILLLAYQNNGAVFGTLALSAVLTAFYMIRMWRIVFFGEARSEVARGAHESGLAMTVPLLVLGLLAVVGGYGNIYGRLAGDLAYLIPHSEEAHTTILVTSIAVMLLGGGLAWLLYRRPDSRDDAIALKSPALFRSLVGLQGVFDSAYGYYVAKVQQRFAMMLNFLEKVFLAGVIVRGTASLVGLVGLGARALQTGSLHAYVYWFLLGVVLLWAIVSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP50</accession>
    <name>A0A139SP50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">AXK12_03775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711369.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03775"/>
    <dbReference type="EnsemblBacteria" id="KXU36260">
        <property type="protein sequence ID" value="KXU36260"/>
        <property type="gene ID" value="AXK12_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="974" mass="104183" checksum="B58DB80DEB143BAC" modified="2016-05-11" version="1">MSSLRDLLAPIDQFESRHSGSADSGELAAMLAQVGYESLDALSAAAVPEDIRLPRRLALPEAVGEAAALAELRGLAAQNQVFRSFIGAGYYDCAVPAVIQRNILENPGWYTAYTPYQSEISQGRLEALLNFQTLVSELTALDIANASMLDEGTAAAEAMMMCHRIKLGGRSDAARFFVSEQCHPQTIEVVRTRAAPLGVEVVVGDHRSFEFGGAEGGGAVPAIVGVLVQYPDTRGSIHDYEAFFARAHAAGALCVVAADLLALTLLRAPGEFGADVAVGSAQRFGVPMGFGGPHAGYLATRDAHKRQMPGRLVGVSKDAQGQPALRLALGTREQHIRREKATSNICTAQVLLGVMASMYAVYHGPSGLRRIAQRTRLLTQILARGLTALGARVNAEPVFDTLTVGNVAAARVHAAAAARRMNLRQIDAYTVGISLDEVTTLAEVETLLSFFGETPTPAPEAIGALDYPAPHARQSAYLAHEVFNRYHTEHEMLRYIKRLEAKDLSLCHSMISLGSCTMKLNATSEMLPITWPEFARLHPHAPAEQWRGYRALFDNLEQWLAEITGFAAVSLQPNAGSQGEYAGLLAIRAYHRSRGEGEQRRVCLIPTSAHGTNPASAAMCGMQVVPVACDEAGNINLDDLRAKAAAHAAELAALMITYPSTHGVFEPGVREVCEIVHTHGGQVYMDGANMNAQVGLSSPGFIGADVCHLNLHKTFCVPHGGGGPGVGPIGVAAHLAPFLPKDGRKGNPTTMAGVAEGEAVNSGSGAVSAAPFGSASILPISWMYIRMMGADGLRRATQRAILNANYIAKRLEGYFPVLYRGNGGLVAHECILEFRDWKPRGVEVEDVAKRLIDYGYHAPTMSFPVPGTLMIEPTESETRAELDRFCDALIFIHAEMSAVASGEADARDNVLKNAPHTAAVVSASEWSHAYSRESAAYPDAHTRATKFWPAVGRVDNVYGDRNLVCACGGMQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP61</accession>
    <name>A0A139SP61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-proFAR isomerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711336.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03640"/>
    <dbReference type="EnsemblBacteria" id="KXU36241">
        <property type="protein sequence ID" value="KXU36241"/>
        <property type="gene ID" value="AXK12_03640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="263" mass="28221" checksum="04D804E55431DA89" modified="2016-05-11" version="1">MTRFRPCIDLHEGKVKQIVGSTLTDDGAGLRTNFVSEQPAEYFSALYRRDGLKGGHLIKLGPGEDNDEAARAALTAYPGGLQIGGGITLENAAVWLIAGASHVIITSYLFDERGRFRPDRLQSLIAEVGAERLVIDLSCRRERDGWVVAMNRWTQPTDLWLNAANLRALSGACAEILVHAADIEGQQNGIDEELVQNLGAYAPMPVTYAGGANSLADLARVDVLSQGRVDLTIGSALDIFGGEGVRYADCVAWNQTDEGGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP67</accession>
    <name>A0A139SP67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="7" type="ORF">AXK12_03700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711356.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03700"/>
    <dbReference type="EnsemblBacteria" id="KXU36251">
        <property type="protein sequence ID" value="KXU36251"/>
        <property type="gene ID" value="AXK12_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2 3" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="6">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="25215" checksum="F664A64B91F508C3" modified="2016-05-11" version="1">MPANADILPTLQAQFPQASVRPSADHPALDVPASDLLALMRTLRDTHGYDLLTDVTAVDWGAQRAGRGTGASGSVALSAANAESAAQPRFTAVYHLYSTTAHDYLRVAVACTGDDDAPSVPSVTSLWAAADWHERETYDMFGIRFEGHPDLRRILMWEGYPYYPLRKEFPLAGIETEWPDADVAAETRISVKPAPMAGGPFVASSGTMNLSEAEPRAKDESWNEVSEKPQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPF7</accession>
    <name>A0A139SPF7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03210"/>
    <dbReference type="EnsemblBacteria" id="KXU36468">
        <property type="protein sequence ID" value="KXU36468"/>
        <property type="gene ID" value="AXK12_03210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="166" mass="17494" checksum="E06D7156F572B61F" modified="2016-05-11" version="1">MLSEIGKAEKTPVLSGEPETGGRVRVALVDHGSPAREVTAVRDEVAAQLAALLSGDTRVAEVAACSMERRPGADYAFNEPLLETQLAREQWRDSAGGRPLIIVAQLFLLPGRHAGPSGDIAQICARAAEAAGVDAVLASVRTVQTEPLATHPLIVELLAQRFAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPJ6</accession>
    <name>A0A139SPJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711227.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03255"/>
    <dbReference type="EnsemblBacteria" id="KXU36476">
        <property type="protein sequence ID" value="KXU36476"/>
        <property type="gene ID" value="AXK12_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="317" mass="33391" checksum="33DA8C8619C047B4" modified="2016-05-11" version="1">MSSLIFNDIVSTIGNTPLVKLNRSAAGLAADIYVKTEFFNPLASVKDRIGRAMIEAAERDGKIQPDSVIIEPTSGNTGIALAFVCAARGYKLILTMPETMSQERRMLLRMLGAEIVLTPGAEGMKGAINRAGELLAEHGKRGFMPQQFENPANPEIHRRTTAEEIWAATGGKIDAFVAGVGTGGTITGVSEVIKARKPDVKTFAVEPSASPVISGGKPGPHKIQGIGAGFIPKNLNTAIIDDIIQVSNEDALETARQTALLDGILGGISTGGNIWAAIQVAKRPEFAGKTIVTVAASFGERYLSTALAEKARLEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPM2</accession>
    <name>A0A139SPM2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711223.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03235"/>
    <dbReference type="EnsemblBacteria" id="KXU36472">
        <property type="protein sequence ID" value="KXU36472"/>
        <property type="gene ID" value="AXK12_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="7">
        <location>
            <begin position="30"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="300" mass="34073" checksum="47AA2D9DF046683E" modified="2016-05-11" version="1">MSNYHLDHLQYLETEAIHIMREVAGEFERPAILFSGGKDSICLLRLAEKAFRPSDIPMPLLNVDTGHHFPELNTFRDARAAELGGKLIVRKVEDAIASGIATPAPGEVSRNRLQIPTLLAATEEFRFDCLIGGARRDEEKARAKERFFSFRDSFGQWDPKNQRPEIWNLYNTRVNSGEHMRAFPISNWTEMDVWEYIKREQLAVPTIYFTHTRQCVRRSGQWLPVTELAPPKPGETVRELGVRVRTIGDIISTGMIESPADDVDDILAELAAARITERSSRADDRSAEAAMEDRKKAGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPN0</accession>
    <name>A0A139SPN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="15" type="ORF">AXK12_03180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711215.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03180"/>
    <dbReference type="EnsemblBacteria" id="KXU36464">
        <property type="protein sequence ID" value="KXU36464"/>
        <property type="gene ID" value="AXK12_03180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="13">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_2" evidence="14">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU36464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="481" mass="52949" checksum="AB05E253192448EC" modified="2016-05-11" version="1">MAIQLYDSLTRTLKPLAASQLDGVFRFYNCGPTVYAPAHIGNFRTFIVNDILRRLLELELGADKVHHVRNLTDVDDRTIQQTRKEGRPLAEITAHWTAKFHADCDALGCLPPHVEPTATGHIREQVDMIECLMERGNAYRAADGSVYFRINSFPDYGALSRIKDRELKITNEAADSDHKDSVSDFALWKAYKPEEDGDVQWPGPRGAAAGRPGWHIECSAMIKKHLGETIDLHTGGVDLLFPHHENEIAQSQCCNGGTTFARHWYHSEHLLVDGTTMSKSKGNYYTLSDLTAKGYSPMAVRYALLSGHPRKQLNFTLDSLHAAERALKTLRNFRAKLAAKPASDLPSRTAETSPSSTRASEPAPTKGVEALFNALHDDLNTPAALGALFTLVNRGADATDAPSLADFDRVLFALGLDLSEAKNVDQAAPEIPAEVTALAEQRWAAKLAKDWGSADALRAQIAALGWAMRDRKDGYSLEPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ22</accession>
    <name>A0A139SQ22_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711201.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36614">
        <property type="protein sequence ID" value="KXU36614"/>
        <property type="gene ID" value="AXK12_03130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="173" mass="20364" checksum="29930B77B1299148" modified="2016-05-11" version="1">MKDKPKVTDFKLGSVFFVPFRDGVNGVFGYVKYDCNTRSNRKSINLPLADIYNRVCRLDEWSEDIKKEEIKIHDMILSLVNHFHKSYFNKRPMVLTDYHTDIIHPVKYGFFKMGTKKLWYDADAKDIVYPDSDEQYREVEMALAPYDQAYIEAIFSGMTVKYGDEIPGFDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ71</accession>
    <name>A0A139SQ71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711198.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03105"/>
    <dbReference type="EnsemblBacteria" id="KXU36611">
        <property type="protein sequence ID" value="KXU36611"/>
        <property type="gene ID" value="AXK12_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="219" mass="24048" checksum="6DB2D84D431F975E" modified="2016-05-11" version="1">MLQAPALSSESLLSALNWRYAVKRFDPARKIAPELWSALEESLVLTPSSYGLQPWHFIVVTDAEKKAALREAAYGQSQVSDCSHFLVFAVRREFGADYVEQHLARACELLGVTRESLAGFGKMLNGAIEGARASDSLHSWQSHQVYIALGNFLTSAALLGVDTCPLEGLSKDKVDEVLGLTGSGYRVQVCCAAGYRAADDRYAERPKLRLPKETLFTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ74</accession>
    <name>A0A139SQ74_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711174.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03015"/>
    <dbReference type="EnsemblBacteria" id="KXU36739">
        <property type="protein sequence ID" value="KXU36739"/>
        <property type="gene ID" value="AXK12_03015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="123" mass="13785" checksum="BBFE23D1FF96B53C" modified="2016-05-11" version="1">MKPQYLLLIDDEAPIRDLLSHFLKTNGYRVHAASGVHEALREVRKEAPDLVISDLQLDDGDGFEMIKEIKTLCPTTPVILLTGVLFDGEVVDKTLKDLIDRYLEKTTPLTKIAETVKELLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ87</accession>
    <name>A0A139SQ87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711161.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02930"/>
    <dbReference type="EnsemblBacteria" id="KXU36726">
        <property type="protein sequence ID" value="KXU36726"/>
        <property type="gene ID" value="AXK12_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="22573" checksum="365534B891591FF6" modified="2016-05-11" version="1">MQLTIPEGDFAGFIFDLDGTLVDTMPQHYCAWRDTLHDFGLKEVLDEALFYAQGGSPTEKVVQTFNAHYGTSFDPITVRDAKELRFAEMIHDTELIEPVIAFARARAAEGCPVSVASGGLRHIVRDTLQAHGLAELFPVVVTVDDVARGKPAPDTFLLAAEKMGVPPERCLVFEDAELGFRAAEAAGMRWVEVPSAPRFGMGFSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQB7</accession>
    <name>A0A139SQB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711150.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36714">
        <property type="protein sequence ID" value="KXU36714"/>
        <property type="gene ID" value="AXK12_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="48"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="256" mass="27128" checksum="864265713CC74578" modified="2016-05-11" version="1">MPHSAPLRVPGTAPSPSPADAFYAQSLELIAAARDKNRATISAVAPVIGHSLATGGMLHVFGSGHSEVLAREIIGRAGGLACINGIPDPTAGFIENLVGYGTALVARYDRRHELRPAETLLVISNSGKNSAPIEVALYAKEKGLHVVGLCSQHMSRTTPTVHPSGKRLHEIADWTLDNLGVPGDTLVPLGNGEMSGPSSTLVGAMLLNLLMLETCAWMQAHGHPLPLLRSQNLPGAIEHNRRVAEPYKHRLSKQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR3</accession>
    <name>A0A139SQR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711121.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36883">
        <property type="protein sequence ID" value="KXU36883"/>
        <property type="gene ID" value="AXK12_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="945" mass="100210" checksum="E85BA28AD9C00129" modified="2016-05-11" version="1">MCKISYDCVAESRRSRSRGRRLTWLLILAFSGLCLAAAKLAHAQLSPPERAYEWLDPTGTGDPTDAAAWLSPGGADLLPTDGAHLNFGTKPALADGYYKWVWDDDIGDWVEGPWVPGDYYVGEIAGLGESRLPARYASIWFGFGAPDEPLNMYTAYTLTGSEITVGYGTDEIDRLIAARGFGTHVFDLDVLIHEVPGLDFRIHNDMPSIFGDEELIFAQTLTSRSGTLIVSGLGRTTINALHGSGELIKEGAGLLYIDATNYLGELTLRGGTLIGEIADDSTLTLAGGVYGFEDGFRTFERDLGDGAAKVRWLVGKSGGFTALDGTELHVTLDGGRTLTWGEADFVSLGSELLFGSAEASGALHWHNALDLGDPSNRSARTIRLNRSSLGDFSLHLSEELIAAAGQTLRFIGSGTVVVSAGNDAFLGDLEIAGVDLVLGDGGRFGDAAHLTVSEGGTLAISIGASEASPLSGNAAITLSSGTLRWDDPHAANATRTLGDIILGGGANRIERSSAANHLRANSLTRIDPRSTLLVELIGPNRSGSLMEFTDTTALESSAIGGIHPWFVVTTGSSAGSSRSDWGIFDSDGHLKRYVTYYAGSEGTWTAGNNVNVTATTTLSDNRTINSLRLGSGVLLLEGHTLTIGSGGILVSNNRPATIYDGGNGSSFGAVTTAGGRPLYIHTHSALTLTAKITGGIDLVKTGAHSLHLNSANSGHSGHTNELGSIYIHQGELHLDGRSRLSSTGTITVGDGGSYAALVLDDHGAGTPILSGQRDLRLRGGHDYAKAPALILIGAHHDLRLNHLSISGNSVLEFRLPVTGGLSKIYSEVFTIDPTGRLFVRGWVQELAKSGTDYTGDRFTHILVSKTSPGLDDYLHQIWFEDYGPAKKTEWAEDNRYWEIVPGDFVRPLPEPSTYGAILAAAGIGLVAWRKRRARAAADTRLANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQW7</accession>
    <name>A0A139SQW7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711106.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02640"/>
    <dbReference type="EnsemblBacteria" id="KXU36927">
        <property type="protein sequence ID" value="KXU36927"/>
        <property type="gene ID" value="AXK12_02640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="186" mass="20344" checksum="78535ED5037E82F5" modified="2016-05-11" version="1">MKPWERVTQACTQRGIKPTARVLLVSIDGGTLQLFRNAQLVKSYLVSTSRRPPSNQKGSLGTPRGLHEIVERIGSGQPIGMVFKGRVPTGQHFSELPLSEQGLSGATDSPGSGNLITSRILWLGGLEDGVNRGGDCDTRSRYIYIHGTNHESRIGQNFSAGCILMRNLDIIELYEEVRTGDLVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQX8</accession>
    <name>A0A139SQX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37015">
        <property type="protein sequence ID" value="KXU37015"/>
        <property type="gene ID" value="AXK12_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="195" mass="20602" checksum="7BF99F0775EA4CBB" modified="2016-05-11" version="1">MVGVAFSGMGGSARSTALRSAQATLANALSATRNRALARGVPVALVVHDDPSNPARYRRMIGIVEDIATAPRVVAVFELPKHAYVLPHRARFTEQMREPDNWVGGNSGNALGSTRFLNPGGVISVAIASPSAELWEYALVTPAGTMSGGGALIVGLAERVEDGPFPIRFQSPEQVRGLMVSNYGLARMIDSRAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQZ8</accession>
    <name>A0A139SQZ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711082.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02375"/>
    <dbReference type="EnsemblBacteria" id="KXU37035">
        <property type="protein sequence ID" value="KXU37035"/>
        <property type="gene ID" value="AXK12_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="356" mass="39339" checksum="1B31574599E84836" modified="2016-05-11" version="1">MKLLITGGSGFIGSNLIRQLLASTEHHILNLDKLSYAANPLSLADLAAHPRYQFAQVDLAAPNTTAALTDHFAQFCPDAVIHLAAETHVDRSIDAPAAFIASNVSGTFALLHAARTHFDQLGGAARERFRVLHVSTDEVYGSLAPDAPAATETQPYAPRSPYSASKAASDHLARAWAHTYALPVIVSTCSNNYGPYQFPEKLIPLALLKALRGEPIPLYGTGENRRNWLYVADHIDALLRLLEHGQVGQTYHIGSDSDLPNLALIRQLCALLDALHPRRDGQPHAAQIRFVADRPGHDFRYALDTTKLRRELGWRPRHDLTTGLRKTVHWYLENTAWWQPLLTHNAPLQRLGAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR04</accession>
    <name>A0A139SR04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711064.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37016">
        <property type="protein sequence ID" value="KXU37016"/>
        <property type="gene ID" value="AXK12_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="159" mass="16570" checksum="61945D1AD686545B" modified="2016-05-11" version="1">MKSRAQGFSLVEVIIAIAVAGGALAVILALLARLLRATEDAADHQTALRLAGAVELRLYEEMGGAFPGGLQAGRVFVADKEGANLRGELESDAVLAPAYFHIAVSPFAQSPLAYQAGRGVLPLRVRVSWPYSAVLSASGNPSASVNTQSVEFIVTLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRB3</accession>
    <name>A0A139SRB3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen-dependent coproporphyrinogen-III oxidase</fullName>
            <shortName evidence="4">CPO</shortName>
            <shortName evidence="4">Coprogen oxidase</shortName>
            <shortName evidence="4">Coproporphyrinogenase</shortName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemF</name>
        <name evidence="6" type="ORF">AXK12_02420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX</text>
            <dbReference type="Rhea" id="RHEA:18257"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="1.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711068.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02420"/>
    <dbReference type="EnsemblBacteria" id="KXU37020">
        <property type="protein sequence ID" value="KXU37020"/>
        <property type="gene ID" value="AXK12_02420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00333">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for dimerization" evidence="4">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="4">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="381" mass="41824" checksum="10390ED15E3E021E" modified="2016-05-11" version="1">MNHTPIPPDAAAVRRYLLDLQARICCELAEEDGGADFGRDEWSRDEARSETSALSGDRHRSAGGDKCASLGGGTAQNPTLSGGGLTRVLSEGAVFEKAGVGFSHVHGTALPPSATAQRPELAGKAWEAMGVSLVIHPRNPYVPTSHANVRFFCTHDQANTQAASGGASSERPTDTRQISQPQTAAAASTWWVAGGFDLTPYYGFEEDCVHWHRTAHDAVAPFGPDLYPRFKNACDDYFFLKHRNEPRGIGGLFFDDFNALGFEQSFALLRSVGDAFLRAYRPIVARRKATPYGERERQFQLLRRGRYAEFNLVWDRGTQFGLQSGGRTESILMSLPPLARWDYAWTPKPGSPEAALTEHFLPKRDWLADHTVAALAATTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS07</accession>
    <name>A0A139SS07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710972.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37385">
        <property type="protein sequence ID" value="KXU37385"/>
        <property type="gene ID" value="AXK12_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="183" mass="19743" checksum="D2150B24E0B4CEE4" modified="2016-05-11" version="1">MPRSSSSRLFPLTLLSAVFAFGGLFLTGCGYQLGTPQSAPLAFSTLYVAPVKMRALIPQADAVLTGAVRERFSRDGRVTLAATPTAAGAVLEITIRNYRRDTATADPDDTGLARKFTVVLIAEMTLREGAEPGTGKPYFSARPIEIRRDIFADGGQQQAEYQILPLLAQDLADKAIHAVLDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS31</accession>
    <name>A0A139SS31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_01840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710956.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01840"/>
    <dbReference type="EnsemblBacteria" id="KXU37368">
        <property type="protein sequence ID" value="KXU37368"/>
        <property type="gene ID" value="AXK12_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="31536" checksum="53435A1A8BDC48C3" modified="2016-05-11" version="1">MLDSLLTPFHYDYMLRAIFVSGLIGCVCGFLSCFITLKGWSLMGDALSHAVVPGVAIAYLLGLPFAAGAFATGLLAAAGMGFVKAKTPLREDAVIGVVFTAFLALGLLLISLKPSGVALQTILLGNILGISDFDIVQIIGVAVGALLVLGLKWRDLLLVSFDPHQARTLGLNVAGLHFVLLALLSATVVAALQAVGAVLVVAMLVTPGATAYLLTDRFGKMITLAMTIGAGTSLVGAYASYFFNGATGGCIVTLQTLLFLAVFYAAPKHGWRAQRAPQAGRPAHQAERPPRFLPNGGAPDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS49</accession>
    <name>A0A139SS49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710932.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37419">
        <property type="protein sequence ID" value="KXU37419"/>
        <property type="gene ID" value="AXK12_01705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="78" mass="8989" checksum="9AB64154FD298716" modified="2016-05-11" version="1">MNTVTDREYAELRKMMVETDAIIAQMRKMNDEREKLRAETMKMQTETKWHPVRYVGGVAIGTILFVAALVGILKAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS96</accession>
    <name>A0A139SS96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="11" type="ORF">AXK12_01690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710929.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01690"/>
    <dbReference type="EnsemblBacteria" id="KXU37417">
        <property type="protein sequence ID" value="KXU37417"/>
        <property type="gene ID" value="AXK12_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="152"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="521" mass="59138" checksum="5676B03D9C41879D" modified="2016-05-11" version="1">MPDFYITTAIDYVNGPPHLGHAYEKVLTDVIARVRRMRGDRVYFLTGVDEHGQKVQQSARARGVAPQQFCDEIAAEFRALLPRLDVSNDDFIRTTEARHKRVVCDLLQRLYDKGEIYKAEYRGYYSTRQEQFLQEKDRNPDGTWPELFGEVTEITESNYFFKLSAYQDWLVRFLTENEAFVFPKFRQKQVLEFLKEPLNDLCISRPKERLEWGIPLPFDADFVTYVWFDALTNYYSAVADKEPAIWPATWHVIGKDILVPPHAVYWPIMLKAADIPLPRGIIAHGWWSIRGDKMAKSTGNFVEPNAFVDSYGTDALRYFLMREMVVGQDSDFSETQFQARYNADLANNLGNLLNRTLNMINRFADGVVPAPEGAAEAAAPEAELRALWEETRAAIPAHWDGFQFHLALERTITFVSATNAYIEKRAPWKLGKSSEPADRALLVRTLATMAEALRLAAVLLRPIIPGSVAKIEAALGYTPPETDWAAECEWGTRLSGAKVAESLVLFPRIQATTSAEAAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSD0</accession>
    <name>A0A139SSD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710938.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01735"/>
    <dbReference type="EnsemblBacteria" id="KXU37424">
        <property type="protein sequence ID" value="KXU37424"/>
        <property type="gene ID" value="AXK12_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="30273" checksum="4FEDD624E6737CAF" modified="2016-05-11" version="1">MVPDSDYRIKLPVFEGPLDLLLFLIRKNELDIYDIPIESVTRQYIDALHAMQELDLEIAGDFFVMAATLMEIKSRLLLPKGQHAVAAESDEDDMDPRWELVHQLVQYKKFKEASEQLDSLITQRHDLIERLGSGPAHSLTEPSERPLQPIDRIKLWQAFNTVLRRLAETRVVGEIHEEQVTVSDRMDDLLARLKTEKRFSFSALLPEKITLRYLVATFLAVLELTRLKRLRLTQDEAFADILCTAVEDNEASEAASESAAEDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSJ7</accession>
    <name>A0A139SSJ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ORF">AXK12_01775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710944.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01775"/>
    <dbReference type="EnsemblBacteria" id="KXU37430">
        <property type="protein sequence ID" value="KXU37430"/>
        <property type="gene ID" value="AXK12_01775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="305"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="487" mass="52669" checksum="6FF9F3CCDB15F2FD" modified="2016-05-11" version="1">MKIVHVTSELFPYIKTGGLADAVAALGAALADKGHEVAVFLPGYRAVREHPDAVKAERRHELRVELGEEFLSGEVRCFSPRQGLTVYLVCRDEFFDRRFPYGTADRGDYEDNAQRFIFFAKAVVETLRLEAGEGASGCRADVVHAHDWQAALVPLLLRVAERRHGQRLAERTVFTIHNIAFQGIAPASRFALTNLPAELRGIEGLEYHGQISTIKAGILFSDTVTTVSPRYAREIQTPEFGCGLDGVVRTRASVLRGLLNGIDPAVWNPATDPLLPAQYSADGLAGKAKCRAALLAAHGLAPAEDGVPVYGMVCRLTEQKGVELLLANAEFFLREDCRLVILGTGARHFEEAVAALAARAPTKIAVSLKLDEAASHLIEAGADFFLMPSLFEPCGLNQMYSQAYGTVPIVSEVGGLADTVADADRDGEHGTGLTHSPTAAAMADALHRSLALFADKSRYAAVQQHGMRRDFSWAQAASAYEALYNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSS9</accession>
    <name>A0A139SSS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">AXK12_01490</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710890.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01490"/>
    <dbReference type="EnsemblBacteria" id="KXU37638">
        <property type="protein sequence ID" value="KXU37638"/>
        <property type="gene ID" value="AXK12_01490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="87"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KXU37638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="363" mass="39957" checksum="2E90107C532D6797" modified="2016-05-11" version="1">MDLEPIRAKIDELDRELVDIINRRLALAQEIGQIKRVTDGEVYVPEREDAVFRKVFASNKGPVNNEALRAIYRELMSAGIALEKPLSIAYLGPEASNTHAAAMKKFGVSLDYHAMASVADSFAAVEKGEADYAVIPIENSTEGSVREALDCFVESDLKVVAQLYTEISHALISNEPLEKITTVYSKDQALAQCRYWLQRHLPQARLVEASSTSRAVQIAAQESGAAAVAGELAAQFYGVPVVARAIQDKADNTTRFFILGRKPTKPIGGGKDVSSFLISLGDGASDRPGGLLKMLMPLAERGINLSKIESRPSKMRPWDYYFFIDVSGHHDEPEMQAALAELRKFCPLVKWLGSYPAVRRESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST01</accession>
    <name>A0A139ST01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01585"/>
    <dbReference type="EnsemblBacteria" id="KXU37664">
        <property type="protein sequence ID" value="KXU37664"/>
        <property type="gene ID" value="AXK12_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032858">
        <property type="entry name" value="CcoP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038414">
        <property type="entry name" value="CcoP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14715">
        <property type="entry name" value="FixP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="175" mass="19283" checksum="02809BCA725CD8A4" modified="2016-05-11" version="1">MIREHTFDGIEEYDKRLPNWWLATFYGAIAFWIGYWFYVEQAQIALSPEAAIELELSRIEAAKLAANSANLDDATLWQMSRNAVFVNAGRETFNSVCASCHLQSLKGVDEGGIGHNLVDDEWAHGGNPTDILAVINNGVLAKGMPAWGPVIGAKKTSEVIAYILSHHTEPAHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST03</accession>
    <name>A0A139ST03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710884.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01455"/>
    <dbReference type="EnsemblBacteria" id="KXU37632">
        <property type="protein sequence ID" value="KXU37632"/>
        <property type="gene ID" value="AXK12_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="90"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="320" mass="34750" checksum="25FDB3C60EF9C6B6" modified="2016-05-11" version="1">MPDAPTEYTVPLGSRRARADKVLAAAFPEHSRVAWQRALCAGLVAADGIAISQADSVSAGQRITFSFPQTEPLALRPVSIPLDVVFEDEHLLAINKASGMVVHPGAATGEDTLVHALLAHCAGQLSGIGGVERPGIVHRLDRETSGLMLAAKTDAAHRGLSEQFAERRVFKEYLALVSGRPQLLSGVVKSPIGRNPNHRHKMAVVPPEKGGKPAHTDWDLVEGFRDWAALMRCTIHTGRTHQIRVHLHSLGHPLLGDAVYGWSLKKMPLPVEISETPARVMLHSEHLAFTHPVTGASLDLRAELPRDMRALIEQLRGVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST57</accession>
    <name>A0A139ST57_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01565"/>
    <dbReference type="EnsemblBacteria" id="KXU37662">
        <property type="protein sequence ID" value="KXU37662"/>
        <property type="gene ID" value="AXK12_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021993">
        <property type="entry name" value="ATPase-cat-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12156">
        <property type="entry name" value="ATPase-cat_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="861" mass="92663" checksum="115D32514AD8D559" modified="2016-05-11" version="1">MLADTPLRAEADTPTKAVSRRRKKAPSCHHCGTALTDHAMRETGFCCSGCAYVYRLIHESGLDAYYRIKDPITAPVDATVFQPQNADWLAELQKNAEAETDEKGSPHTPHNQAATTPRQVKRSASATAKLGIQGISCAGCVWLIEKLFSQIPGARRITVNAQLGHMEISWTAGELSLPGFAQKLASFNYLVGPHDSSTAELESRALIRRIGLCTAFVMNTMLFTLPTYFGMEADFPYARLFGTLSLAFGTLSMLAGGGYFVRRAWAGLRHGLLHIDLPISLGILGAYLGSLYGWAIGEETYVYFDFVSTFIVLMLIGRWAQVCAVERNRRRLLSLQPRPQHIPILQPDGTLQPTPPERLQPGQILELRSGQILPVEAILETHASAAPESDRALSPASLAASTAREVEFSLASINGESAPRRFTAGQRIPAGALNLSRTPIRLRSTQAWAHSLLAELTATQSETEHRNPLLERIVQGYLIGILGIAALAALFWGFHTGGDLLKTGAIVTAILVVSCPCAIGLAFPLAEEIASVALRRRGVFVRSPRLWSLLHKVRTLVFDKTGTLTLETPILQNPEQIATLSEEARSALYSLIRDNPHPVSQCLLEALLASGPTPAALEGDVLEEIGCGVSLGPWSLGKAGWKAQEADGNARSATAMSPQAKGSATLFAYNDTPLATFHLADSIRSDAPEAIAKLRALGLEAHILSGDATNKVQATAAQLGLAPAHGHGQMSPQDKADWLRTHAPSDALMLGDGLNDSLAFDAALLRGTPVIHRGTLAQKADFYYLGRGIGGIHALFEVNAIRRRAERVILIFSVSYNLLAVGFAALGFINPLIAAILMPINSLLTLTLVSASMKGSKLQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST84</accession>
    <name>A0A139ST84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710834.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01200"/>
    <dbReference type="EnsemblBacteria" id="KXU37808">
        <property type="protein sequence ID" value="KXU37808"/>
        <property type="gene ID" value="AXK12_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299419" evidence="2">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="190" mass="20646" checksum="61B2B89C0D660D82" modified="2016-05-11" version="1">MLLRLFLIFSTLGLSAHAQGNALQYELANLREDMRGLVQRVGELTLRVEQLERENATLRSRSDSAAQSYATVSQLNDAVADLNRIVKAAASSSKGEVLKEVDRKISALAKQTNAALDSLAKGQAQRPAVQTSFSDDYSQQGTSYTVQRGDTISSIAQKTGARARDIINANKIGDPTRLQVGQTLFIPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST85</accession>
    <name>A0A139ST85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37789">
        <property type="protein sequence ID" value="KXU37789"/>
        <property type="gene ID" value="AXK12_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="221" mass="24511" checksum="CF315AE2A29DAAEA" modified="2016-05-11" version="1">MGLRMSGKHEGTAIVYLQGNQNNTFTGNVEVSGGSNYLALGKTNGAIAVLGNVFVSSGAVLRFDASQQLRFTSNVTLKNATLYHSVEKKEIRNKFHRLTVSGSRGVVSFGSGGTHSHKRYLYIDELVIEDKARIEVNEWAPGRDFFLVKKTMNKEDLDALMGKIHFRGWLPGRTHLESYDKDYWQISGTPEPSTYGAIFGALGLGLSAWRARRKRRSQVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST91</accession>
    <name>A0A139ST91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="15">BCAT</shortName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvE</name>
        <name evidence="16" type="ORF">AXK12_01115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 15">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710819.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01115"/>
    <dbReference type="EnsemblBacteria" id="KXU37793">
        <property type="protein sequence ID" value="KXU37793"/>
        <property type="gene ID" value="AXK12_01115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="31573" checksum="193B03106C32F66B" modified="2016-05-11" version="1">MKIYLDGQFVDSADAKISVFDHGLLYGDGVFEGIRLYGGNVFRLEEHLERLEYSARAVMLDIPHTRAELSEIVCETCRQNELTDAYIRLVVTRGIGDLGLAPWTCPKPSVFVIASKISLYPQEYYDNGLAIVTVPTRRIAPGALPATVKSLNYLNNILGKIEAKQFGALEAIMLNEQGYVAECTADNIFIVHKGELITPATSQGALKGITRDAVLDIAAELGVPLRDANMTRYDVWCADECFLTGSGAEVVPVIALDGRRIGDGRPGPITRDVLASFRRRVLVEGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA5</accession>
    <name>A0A139STA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="12" type="ORF">AXK12_01190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710833.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01190"/>
    <dbReference type="EnsemblBacteria" id="KXU37807">
        <property type="protein sequence ID" value="KXU37807"/>
        <property type="gene ID" value="AXK12_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="205"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="532" mass="58913" checksum="658B5D7E1119AA10" modified="2016-05-11" version="1">MSSHARTQNRIVAIVGRPNVGKSRLFNRLARRRISIVHDEAGITRDVISTEIEEGRYTLLDTSGLGLTGSDTPQRITAAAEQQVDFAIDTAGLILFVIDGLSGTTALDEQIARKLRRAKAKVRLVVNKADFDEARVDLAEAYRFGLGEPISVSAEHGHGEGRLREAILDALGPAPEPDGEADDAGVENAEEAAPQPYKSREKRPLRLCFLGRPNVGKSSLSNRLLASERLIVSDMPGTTRDAVELPFTFTGRNGRSYPFSLIDTAGIKAATKLAAPVEYFSRLRSLDAIQRADVVFLVLDALEGVTQQDKAIAGEAVKERKPIVVVVNKWDLVHAAFEKPEGLKGFASERDYREKYERAVFERLFFTPGAPLIFASAHSELALDRMMNAAVKLDRTLEKKLPTGRLNRLLAELTERTPPPVVGSRRFRIYYATQTGRRPFRIRIFCNREDRLPESYRRYLESGVIREFKLEGCPVYFDLVGKEKHTPGASYTSRKNSAGTEAHSPTPAKWRSAEAAELGADNFGGDYTTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU21</accession>
    <name>A0A139SU21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="1">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_00970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710791.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00970"/>
    <dbReference type="EnsemblBacteria" id="KXU37960">
        <property type="protein sequence ID" value="KXU37960"/>
        <property type="gene ID" value="AXK12_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="362" mass="39974" checksum="3654EF8EF57F66EF" modified="2016-05-11" version="1">MSQLPKLPSGHILGQPLTALAPMQDVTDLAFMRVIAHYGAPDYFFTEFFRVHSQSRPEKHILRSIDENDTGRPIFAQLIGEDTPQLIRTVRELRTHAIAGIDLNLGCPAPKVYKKNVGGGLLRDPQRIAELLAALRDACGSDCPFTVKMRIGFEDTAHFNTILDSVSQHRVDLLSVHGRTVREGYRSEVHYDFIAHAAARVPCPVLANGNITSATKARDVLTATGSAGVMIGRHAIRNPWIFSQCRDTLADREPPPVVLAQVRDYIERLYEATRSADFPERAHVNKMKKYLNFVGQSVDPAGAFLHAIRRASTATELFQICDTHLLSEPGKPFSDEPYPGVIARPNCETPQSDGCSLETVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHD0</accession>
    <name>A0A139SHD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="6" type="ORF">AXK12_08025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713223.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08025"/>
    <dbReference type="EnsemblBacteria" id="KXU33978">
        <property type="protein sequence ID" value="KXU33978"/>
        <property type="gene ID" value="AXK12_08025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="5">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="216" mass="23787" checksum="B35FEE991AD534A8" modified="2016-05-11" version="1">MPLETQPTGRLISFEGPEGSGKSTQTSLLAAHLQKLGKEVLTTREPGGTEIGEQIRNIIVHNSRGDEMCPETELLLFTAARAQLVREVIAPALCAGKHVLSDRFLDSSTVYQGIARNLASGPVAQINHFAIGNVMPDITVIIDVPPEVSLSRLAQRVTDVPDRMERENIDFYRKVREGYLLLAKNMPDRVVLVDGTRTTAQVAQAIWEHVQVRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHE5</accession>
    <name>A0A139SHE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713221.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08020"/>
    <dbReference type="EnsemblBacteria" id="KXU33977">
        <property type="protein sequence ID" value="KXU33977"/>
        <property type="gene ID" value="AXK12_08020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="381" mass="41136" checksum="498187C3B036F2FE" modified="2016-05-11" version="1">MDFKTRTLAELRTASAAQALATKHVLVGFDGFVDTIVAPVSRRAGQGDNFTPFRTIEEFGQRILGASGKSTNIEFFPTMEKLGGNGPIMANALLAHELALTYIGALGAPNTHPVFSSITERAKEVFSLCQAGSTTAVEFTDGKLLLGQMRSLDEVTPARIRAVIGEERYLATLEASDLIAVLNWVMIPNLTEVFVDLVDNVLPKIPRKRRHADGTETERIYFFDLCDPEKRSPSDLSYALDTIGRFSEFGSVTLGLNLKEAQQVYAVLGFGVETESESGLRNMAARIRERLGLSTVVVHPKESAASATRDGTHWVPGPFVAEPFISTGAGDHFNAGFATGQLLGLSPEACLAVGVCTSGHYVRTAKSPTIADIEALLTSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG8</accession>
    <name>A0A139SHG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ORF">AXK12_08145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713262.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08145"/>
    <dbReference type="EnsemblBacteria" id="KXU33997">
        <property type="protein sequence ID" value="KXU33997"/>
        <property type="gene ID" value="AXK12_08145"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="231" mass="23598" checksum="D66ADF519AA27E4F" modified="2016-05-11" version="1">MSLLFAAAVLGYLLGAIPFGYLVARAKGVNIFEVGSKSPGATNVRRTLGPAAGNLVFALDVLKGALAACWALHAHSSVTLNAAALGLPALGSVDIAGTSWYPLGAAGLVGALLGHSFSCFTKFRGGKGVATGAGGVLVLVPIAGGIGALLWGATFYATRYVSLASMLAALSLPLSTWALGRPGWLVGVTTLIALFVIYRHRENCRRLLAGTENRFAKKQRPSTPAPPVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH0</accession>
    <name>A0A139SHH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tdh</name>
        <name evidence="8" type="ORF">AXK12_08160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713265.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08160"/>
    <dbReference type="EnsemblBacteria" id="KXU33999">
        <property type="protein sequence ID" value="KXU33999"/>
        <property type="gene ID" value="AXK12_08160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="342" mass="37153" checksum="0764561F1BE9DE7A" modified="2016-05-11" version="1">MRAIAKTTPGPGLALIDAPIPEPGINDVLIKIKQTSICGTDLHIYNWDHWAEQTIRPPMIIGHEFVGTIDRVGANVKGFAPGDLVDGEGHIVCGMCRNCLAGRRHLCRDTQGVGVNRDGAFAQYLCIPAANAVHVDPAIPLDVLSCFDPLGNATHTALQFDLVGEDVLITGAGPIGCMAAAIARHVGARRVVVSDVNPDRLALASRMGATHTVDASREKLQDVQRELGMHEGFDVGLEMSGNPRALDAMIDNMTHGGRIALLGIMPDAAPVDWNKVVFNMLTIKGVYGREMYETWYKMTAMIQSGLDISPVITHRFHYRDFEHAFALMRSGKSGKIILTWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH7</accession>
    <name>A0A139SHH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08345"/>
    <dbReference type="EnsemblBacteria" id="KXU34028">
        <property type="protein sequence ID" value="KXU34028"/>
        <property type="gene ID" value="AXK12_08345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="441" mass="48851" checksum="1CCC1A305ABE24C7" modified="2016-05-11" version="1">MSSPNVTTATASVALAANAVSAAAAPVSASPASTKALAAKFLGVGLIGIAATALGLFVSPPKTVVLAWLVGVSFWTAIAIGMLLLVLIHHIFDASWSVVLRRQFEHGLASFKWLGLLFAPLLIITWMQPGFIWDWTNLASPLHGGHGTVGDDVLYIKKAGFLNTTMLTAMSVGFFLIWMWLSARLRKASFTQDSDGNVGWTTMNRTTAAFGIPLVALSLTGAAIYWMKSLEYHWFSTMYGVWFFANCARGALSIGIVITLWLSARGDYQGILNKNHLHSIGQLMLAFTVFWAYVTFSQYFLIWNANVPEETFWYNLREINNSDGQPNQWKWVGMLLLFGHFFGPFLALLSYRFKVTPHIIRRIAYWILAIILVDLCYNILPALKDAHGDPEPFLSMTLLWVVTAVIGVGGVCAWAYLRSFPSAKLIPIRDPRITECLTHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHJ1</accession>
    <name>A0A139SHJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713309.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08295"/>
    <dbReference type="EnsemblBacteria" id="KXU34019">
        <property type="protein sequence ID" value="KXU34019"/>
        <property type="gene ID" value="AXK12_08295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="389" mass="43377" checksum="60EFA164731E6161" modified="2016-05-11" version="1">MSIETSSHPAPTYNRDHPFLARLVENRMLSRPGSDKETRHMVVDLEDSGLVYKPGDSLGVYGLNRDCEVAEIIERLGATGEELVTPMRATEPVPLRLALTRDCALAGPTKKTVEIFAAKVSDAAQKAQLEALLAPEAKPQLDDFLYNRAFVDFLAEYPSAKFEPQEFVSMLRRLVPRLYSIASSPRVSPKSVDLTVAVVRYTTNGRDRVGVCTSYLSDRVPLGERVPVFVSHSHFAPPDDTSADCIMVGPGTGIAPFRSFVQDRVALGASGKNWIFFGEQHAALDYLYEEEWADYVAKGQVQRLDLAWSRDQAEKVYVQDKMRASAAELWAWLERGAYFYVCGDAKRMAKDVDKALHEIIAEQGGLGEAGAADYVKQLKKDKRYQRDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHN6</accession>
    <name>A0A139SHN6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_08130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713257.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08130"/>
    <dbReference type="EnsemblBacteria" id="KXU33994">
        <property type="protein sequence ID" value="KXU33994"/>
        <property type="gene ID" value="AXK12_08130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="97"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="452" mass="49541" checksum="3075A74393C9ABCB" modified="2016-05-11" version="1">MRFISTRGLAEPLGFSDAVATGLAPDGGLFLPETLPDLSAQWAQWAGLGYAELCYEFIKLFATDISPDTLREIVRKSYQHFDHAQTAPLVALDSSTYVLELFHGPTLAFKDFAMQLLGNLYEHQCAQRGESINVLGATSGDTGAAAIHALLGKPGTAIFILYPDGRVSPLQERQMTCTGADNVFALAIDGSFDDAQAALKTIFGDTAFRLKNRLSAVNSINLARVLAQCVYYLYAWLQLPSEARERAEFVVPTGNFGNVLAGWLLRRMGVPIPGFKVATNQNDILYRLFTTGEYRVAEVQPSLAPSMDIQVASNFERFLYYQLGSDAAKVREVMAACAKDGVYRFEDFDRSAFSASRCTDAEIPEIIARVRRRYGYLVDPHTACAFKELSPEKVSVVLATASPTKFPETIGEAIGAEPKHPRLEVLGKLPIVKHRLPASVKAITDFVEAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHY2</accession>
    <name>A0A139SHY2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_07910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713169.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07910"/>
    <dbReference type="EnsemblBacteria" id="KXU34188">
        <property type="protein sequence ID" value="KXU34188"/>
        <property type="gene ID" value="AXK12_07910"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="14"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="443" mass="44875" checksum="47CA80A4403BE1FC" modified="2016-05-11" version="1">MSVIPSVHSSRRRVVVTGLGAVTPVGNSAGETWAALAAGKSGIGPISRFDASGCSAQIAGEVRGLEPTGAVASPLAPRGADGPPLTQVFTPKDMKKFGRFTHLGAVAAVEAYADSGLDAARAELSPERMGVNLGVGLGGLPEMEAMHDTWQAGGFRKISPFFIIQIAPNLLAGQVSLLLDFRGPNMSVASACATSGHSLGEAAAAIARGEAEVMIAGGAESTITPLAVGAFAQMRALSTRNDAPAIASRPYDADRDGFVLGEGAVVFVLEEYEHARRRGARIYAELRGYGASADAYHLTSLAPGGEGSVRSMRAALESGGLAPSDVDYVSAHATSTPGGDGEEAAAIAAVFGEAKSKLNVSGVKSMTGHLLGGAGALGAFAAVKAIAEGLVPPTINLDNVDPDCAASGLDFTPNVAVKREVRAALSNCFGFGGTNASLSFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI02</accession>
    <name>A0A139SI02_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713202.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07865"/>
    <dbReference type="EnsemblBacteria" id="KXU34205">
        <property type="protein sequence ID" value="KXU34205"/>
        <property type="gene ID" value="AXK12_07865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="269" mass="30306" checksum="D0362602030D6B5E" modified="2016-05-11" version="1">MPLVISKYAQVFLVGLQSNLVYRWNFLLRGVFSLFHLLGVFILWSAAFSGNATIGGFDVRQTMTYFISLIVLQFFVAAANEDHQVSDEIRNGLINQFLLKPISYFAYRFTLYLAARLVSGFLVLIPLAAAFPLLRDYIVMPTEPWRYVAAVPALLLSGLIQFSIAYCFGLLSFWFLEIQGFIMLSYAVETVLGGNLFPLDLMPAPIFKAAQYLPFYYQMYFPAAILTGRIGLESATSGLLIQSAWVCVLFLVSHFLWKRGLWLHTAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID6</accession>
    <name>A0A139SID6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712983.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07375"/>
    <dbReference type="EnsemblBacteria" id="KXU34293">
        <property type="protein sequence ID" value="KXU34293"/>
        <property type="gene ID" value="AXK12_07375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="291" mass="32699" checksum="C26E045A90895610" modified="2016-05-11" version="1">MTTRWNYAPWVFLTPFLGLFGLFAVWPLIHSMVLAMQQTYGPGHSQWVGLHNFKFLLSDPLFWKATANTVKFAVGTLAFQLPIALGLAILLNSPGLKGRALFRLTFFAPSLVGLPFVAMLFAPIFERRTGLLNVMLHNITSAWDPDFAWTQNYIMTALIIASTWMYAGFNMVYFLAALQNVSKELLEAAEIDGAGPWHRFWHITLPEITPVAGFVTLLSIIGSFQLFELSWIMLGDSAGPDNRGLTIVMYLYQTGFQTGDLGYASTIGWVLALILMSVAYIQRRIMKRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF9</accession>
    <name>A0A139SIF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">AXK12_07635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713074.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07635"/>
    <dbReference type="EnsemblBacteria" id="KXU34337">
        <property type="protein sequence ID" value="KXU34337"/>
        <property type="gene ID" value="AXK12_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="287" mass="31208" checksum="DA7B70EBC6B341A0" modified="2016-05-11" version="1">MPLSYTATRDLLAQLGHNPKRFLGQNFLVDGNIVRKSLELAQVASGDRVVEVGPGLGTLTRALLATGAEVWAVEKDRRLCEHLRETLGALPGLHLMEGDAVEHPLAGLPEELAATAKIVANLPYAISTPWMVGVLSGLALPKRAVLMLQLEAAERYAAQPGTKAFGAVSIFLQSAYEIAPGHRVAGTCFYPRPDVDSYLLHLVRRERPFVFSTETQAVIRACFQQRRKQLGSLLRGVSGGPLPQNAAANWLDELAAAGFSPKTRPEAVPISLWQKLEAHCIRPLETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIG0</accession>
    <name>A0A139SIG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_07490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713021.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07490"/>
    <dbReference type="EnsemblBacteria" id="KXU34311">
        <property type="protein sequence ID" value="KXU34311"/>
        <property type="gene ID" value="AXK12_07490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="201" mass="21109" checksum="80672C692BF37F75" modified="2016-05-11" version="1">MALQKISEIRGRAVTVPGNDIDTDRIIPARFLKCVTFDTLGEGLFADDRKAAEGGHPLDDPRYVGASILLSGANFGCGSSREHAPQALKKFGFRAVVAENFAEIFFGNATNIGLTCVNAAREDIGKISAAIAADPSVAVTVDLGAQEIRFGGECVSLTIREAARDALVNGRWDAIAELLEGSEAVAATAAGLPYVKGWSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIG6</accession>
    <name>A0A139SIG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712967.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07330"/>
    <dbReference type="EnsemblBacteria" id="KXU34284">
        <property type="protein sequence ID" value="KXU34284"/>
        <property type="gene ID" value="AXK12_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299300" evidence="2">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="256" mass="27875" checksum="4E44E22FD890D334" modified="2016-05-11" version="1">MPYAGSLLLLVCLLFTPLLSAAGGNAGPDSPAFQEARALFMAQRYPESRRAFEELGSTTEPDNPRIHYYLGRIAIKRSDERDAIFHLERATALAPSNSGYFAELGAAYALALDKAATLKKPGLARKVRSTLEHAVTLDPSNLDAREGLVDYYRQAPSFLGGGIAKAFAQAEQIRAQDAERGTRLLAHLYLRSNDTARAIEVYEAFLIDNPDNAFAHYTLGQLAAKVGEKTKARQAYETALTLAPDFAAARIALDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIJ1</accession>
    <name>A0A139SIJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF3817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713082.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34341">
        <property type="protein sequence ID" value="KXU34341"/>
        <property type="gene ID" value="AXK12_07660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="97" mass="10652" checksum="B88A2CDF5726B870" modified="2016-05-11" version="1">MSFLRAIVLAEASSFALLLGVAMPLKYAAGLPQAVRIVGMLHGVLFLILCWALLQAWMSEKLTAKRALAVFGITFIPLAPFFFDKRLKEWEGGGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIL1</accession>
    <name>A0A139SIL1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07620"/>
    <dbReference type="EnsemblBacteria" id="KXU34334">
        <property type="protein sequence ID" value="KXU34334"/>
        <property type="gene ID" value="AXK12_07620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="323" mass="37197" checksum="72FFB1ABC61F9A6F" modified="2016-05-11" version="1">MPQNPKTETEHAEAEAEIPSAVLARWWMPFADFLGKERHYSPYTIRNYARAFEDFYWWLHAAGLWTEDGLEGLDPRDMRDFVIEAQHRYSARTLHNHVSGLRSLIKFWLSRERIRRDPFLGVPLPKLEKTLPKFLTEDQMKRLLLGPQRLLENEAIEPFLAWRDRLAMELLYGAGLRVSELVSLNYGMLNLNDGIARVLGKGRKERLCPIGKVALTVLKKFRRDFARFTGPSDPVLVTPEHARVSVAQVEKLLKRYLALAELPLEISPHKLRHSYATHLLNAGADLRLVQELLGHAELATTQVYTHVSVARLQEIYAKAHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIS3</accession>
    <name>A0A139SIS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712907.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34421">
        <property type="protein sequence ID" value="KXU34421"/>
        <property type="gene ID" value="AXK12_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299270" evidence="1">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="295" mass="33271" checksum="C191C8F153D7202C" modified="2016-05-11" version="1">MSLPRFALRLRALTTRSPIWLTAFGLAFLGLSNFCAFAANTRPNDDPWLDVINTRYTAASHKFEKLAKASPDDTRLTLAYAASLLTRDPMTRANVRTSRSILIDLLSKLPVSETHYRPLVLLLLGRIDHDHIEPVQFESSRAFYEQLLREYPQHPLADQAAVQLHLLIYLQSPESRSGEVVSQIEATLPTVSNKSHRLRLLGLATRIYLDRLKDKSAALSHLIAAQEEGSDDKSLDLHIAYLARQLGRLELAAKHYRAFYESSPRDNRAYTARRLAQELEEASKMSTAVAKPTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIZ6</accession>
    <name>A0A139SIZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">AXK12_07285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712856.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07285"/>
    <dbReference type="EnsemblBacteria" id="KXU34545">
        <property type="protein sequence ID" value="KXU34545"/>
        <property type="gene ID" value="AXK12_07285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="193"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="388" mass="41790" checksum="F269BA4FD1D72DC2" modified="2016-05-11" version="1">MRSIVISCGGTGGHLTPGVALAEGLLARGEKRGAPTRVTLLISQKKIDARLSERYPQLRFVAVPGTGFSWAPARLLRCIVSQFQGLLFCLKLLTREKPSVVLGMGGFTSAGVAVAARLLGIPLALHESNRVSGLATRTLGRLAVRVYLPEGVRLTGIRPTCIRHVGLPVRCEISPKPHGEACAKLGLDPKRPVIVIFGGSQGAGPLNDWAEAHWSALASEGVQVYCVTGPGKGEAGIRELPLKRGGTAETEPVELQREVRQTNQPATVRAVFVPFCDDVATLLSAADLVVSRAGAGTIAELIRCATPAILVPYPHAADDHQRANAAFFEKRGGGIVIEQSELGRLQREVLDTIFNEWLLHRLKQNLRQMEREDAISVILDDLETLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ21</accession>
    <name>A0A139SJ21_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplS</name>
        <name evidence="5" type="ORF">AXK12_07210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712829.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07210"/>
    <dbReference type="EnsemblBacteria" id="KXU34533">
        <property type="protein sequence ID" value="KXU34533"/>
        <property type="gene ID" value="AXK12_07210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="122" mass="13871" checksum="66622668B8C73AF1" modified="2016-05-11" version="1">MNPIVKEITATQIKAQLPQFRVGDGVKVHTKVREGDKERVQIFAGIVIARKGAGIQETFTVRRISYGEGVEKVFPVHSPNVAKIEIDRQSEPMRARLYYLRKRKGKAAMAIREVRAEKRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJF8</accession>
    <name>A0A139SJF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712770.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07050"/>
    <dbReference type="EnsemblBacteria" id="KXU34692">
        <property type="protein sequence ID" value="KXU34692"/>
        <property type="gene ID" value="AXK12_07050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="28966" checksum="B5935151D7253F74" modified="2016-05-11" version="1">MHALPVSVIIVARNEAANLPRCLDSVRGWVAEILVALNNTTDSSAEIARARGATVHALSWAGYRDTKNAALALAAQPWALCLDADEEVSPALRHALAAFFASGRAADFVGARFPRKVWFINRWITHGDWYPDLSLRLVLREKSRWGGDAFVHEKMVCDGPVATLRGDLHHYSFPTLASHVDKITPFAALFVKQQHARGRHFSLAAALVRPTWRFVRAYFFRLGFLDGYPGLYIAVATAFGAFVRYSSLYEAETQKEPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR4</accession>
    <name>A0A139SJR4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712737.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06975"/>
    <dbReference type="EnsemblBacteria" id="KXU34763">
        <property type="protein sequence ID" value="KXU34763"/>
        <property type="gene ID" value="AXK12_06975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="54"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="236" mass="25625" checksum="99802C31534C8C78" modified="2016-05-11" version="1">MKTFVKLVLPSALLLPFADEGSAQVVNKYDIPDWANFAKYEEANQAAPEGAVVFMGDSVTEGWALEHPDFFKENGYLCRGISGQTTSQMLVRFRADVIALKPRAVVILAGINDIAQNTGYIAVENTFGNIVSMSEIALANGVRPILCAVPPAQSIPWNPKIEAPAELVIRLNGMLREYAETQGLPYVDYASALQDEHGGVSKSYAPDEIHPASEGYRVMETVVQPVIEKLTAPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJT2</accession>
    <name>A0A139SJT2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">greA</name>
        <name evidence="7" type="ORF">AXK12_06915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712716.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06915"/>
    <dbReference type="EnsemblBacteria" id="KXU34811">
        <property type="protein sequence ID" value="KXU34811"/>
        <property type="gene ID" value="AXK12_06915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="459"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="536"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="618" mass="68327" checksum="3EBBE1EAB33F98B9" modified="2016-05-11" version="1">MNPEAVSALIAKNPALKAAKTKLEAMTPGTYCVHRSWGFGQIKSYDDAAQRLIIDFKDKPGHPMDPAFCLSTMELLPANHLLVRKETDGAKIAELIAENPAQLLVEALESYPNHAATQIEIEIVLAQVVGAEKFKKWWSAAKKVITKDPRITIPEKKTECYILREKPISAEDEILEQFRGTRSARRRIALAVELLDTANKKNLKEELGEILQGVTEAVRDSNQLGKAERLHGAAVRDDLAELLGHKGELAPTQASLIADARDLPTVAETIPVQFQRRFLNLILDTHPIEARDILFNLLKVSQGKFTTECINFLVEHDHGDELAATLGRWQTEQNLRAPVLLWIVKNRHSKKFAKLLHDLITPRLLSAIFFAIDYEALQSSTVRRIPLADILSDDSELIADLLSTADPETARDLANTLLLNQGFEDLTKKSLLARFIKIFPSIQAIVASEADGKDEQLLVSRASHDRKREEYEAIISKKIPENSKAIAAAREHGDLKENSEYKMAKQDQSVLMAQKALLERDLARAQITDFSEASTAQVSVGTVVDIKSANTGESTRYTLLGAWDGEPEKNIISYKTALGAALIGKKAGESVTIKIGNNEETYTIDRIARYADAAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV9</accession>
    <name>A0A139SJV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712519.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06375"/>
    <dbReference type="EnsemblBacteria" id="KXU34862">
        <property type="protein sequence ID" value="KXU34862"/>
        <property type="gene ID" value="AXK12_06375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007230332" evidence="2">
        <location>
            <begin position="27"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="494" mass="52514" checksum="23D26EFF4B3F8BA2" modified="2016-05-11" version="1">MALSHTLSRSLALSAAALVLASCSLAPKYKRPTAPVAEAYPHADTMSSGTGTTTAAATLRQTLSAQTLGGDLRLNRILALALENNRDLHITALNVERVRALYRIQRAATLPSLAATGDATRRQTPAALSPSGTRSIDSTYQAGLTLPAYELDFFGRVASLREAALQQYLASEEAHHSAHIALISAVSRQYFGLLAADEQLALAQQTLDAAERSYALNRQSFEAGVASELDLRTAEAQREAVRASVAQLEQSRDLAHNALVLLVGSPLPATLPAPGSLATQQLIDNLPAGLPSELLTRRPDIRAAEHSLRAANANIGVARAAFFPAVRLTAFGGSASPELSDLFEGASKAWTFAPNIALPLFAGGANRAQLDAAKLANRIEVANYEKTIQNAFREVADALAIAKSIDIQIDAQTARVTAATRRYELSEARHKAGVDSYLTVLLAQQELFTAQQQLVTARLSRLNNLVSLYAALGGGWDDTSETAAQTTARLTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX7</accession>
    <name>A0A139SJX7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplV</name>
        <name evidence="11" type="ORF">AXK12_06790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712674.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06790"/>
    <dbReference type="EnsemblBacteria" id="KXU34790">
        <property type="protein sequence ID" value="KXU34790"/>
        <property type="gene ID" value="AXK12_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="114" mass="12543" checksum="0E2A0B433D92D8F6" modified="2016-05-11" version="1">MEVQSLTRYARMSPKKVREVARTIQGRKAAEAVEFLTLVPRKSARLIVKTLKSAIANAENNNNLSADSLTVKSAIIENGPVLKRFKAGARGTAKPRRKKMSHIRIVLSDGNTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK06</accession>
    <name>A0A139SK06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712527.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06400"/>
    <dbReference type="EnsemblBacteria" id="KXU34866">
        <property type="protein sequence ID" value="KXU34866"/>
        <property type="gene ID" value="AXK12_06400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="561" mass="61760" checksum="09C9482FB7F6314A" modified="2016-05-11" version="1">MFTWIQRYFQRHFGVIIVVILAAMAIPLIVVFTPSAGGIGRGGQFAQKRDVFGYNLASVEDQSRLIGDASLSVMLQMGYVGLSDEQLQEYALQRIAALHLAEELGLPKSSEAEITAHIKSLPVFLNEDGRFNAQHYAQFRDSLKNDARIRETDVSRVIADDIRADKVRNLLAGPGYVLDSDIVDQLQRVDTTWTLELAHIDYASYSPEIAPTNDQLAKFFGDNTFRYQTPPRLVASYADFPLSRYLPQVSTNEAELRQVFDSMPGRFAKPAESGNAEASETPAQAQAAGPEDFALVRDQVEALVLSEKARQLATRAASDLTLALYEASLPNDANTRAALLAAHQVEEKPLAPFAENRGPDELGNLASVTTEAFKLNAEQFYSDAIPVRDGAVVLFWKELLPIYTPLLSEVLERVRTDYIEEQKREQFVELGRRVKAQIEARLMGGDSFAAAAASAAESAGVAIEASALAPFSLASPPQDGSFTAFNLLENLEESQVSEMTLSDTRGTFVYTAKRQVPDLTAANPRFGEIREQLAELTSHVGVIRILSDLVEQELRRSEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK14</accession>
    <name>A0A139SK14_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_06590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712582.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06590"/>
    <dbReference type="EnsemblBacteria" id="KXU34895">
        <property type="protein sequence ID" value="KXU34895"/>
        <property type="gene ID" value="AXK12_06590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="298"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="412" mass="44656" checksum="4423C7D29DE28906" modified="2016-05-11" version="1">MTWPFYLALRQLFPKGRVFPFFTVISVLGVALGVALLIVSTSVMGGFGHQIRQMIVDTQGEVQLRAYGLLQDPEAVLAQVEAVPGVVAATPFAEGVAMLEFARKPVFPAIQGIDLERAEAVVPLRRFVRAGSLDALDDDGVILSAPLAESLGIRLGSRVDLYSPLLLERLKGEELPMPRELEVVGIFEIGHQQLDNALALVTLRTMQELYGLGEAVHGINVKLAAGSDPDAVASRINARLADEALPVRARSWLDANEDFLFVLQLEKNMIFFLLTFIIVVSAFSVASSLLIAVVRKTREIGLLGALGARPWAVAACFCFQGFFIGLVGTGCGLGLGLTFLHFRNDVVRVFTELTGSEEVLARFYQFSQLPAHTARADLLLIIASAIVISTLAGLLPAWRAARLRPVEALRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK48</accession>
    <name>A0A139SK48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712449.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06180"/>
    <dbReference type="EnsemblBacteria" id="KXU34952">
        <property type="protein sequence ID" value="KXU34952"/>
        <property type="gene ID" value="AXK12_06180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="41313" checksum="A05E8AECE6F75947" modified="2016-05-11" version="1">MSTTPPPAKLAEVLNLFEIEGRFANATAYGSGHINDTFLVHCEAPTGQARRYIAQRINDRIFKNIPALMDNVKRVTEHLARKVAPPKRNRQLTLIPTVDAAPYARDADGEWWRIYDFIEGAHTIDRVTTVHQARETAHAFGDFQAQLSDLPGPRLHETILNFHNTRSRFDSFRVALATDSLGRASNAQPEIDYALSLEADCDPLLELLARGEVSERITHNDTKINNVMLDNATGRAVAVIDFDTLMPGLPLYDFGDMVRTATSSTLEDDPDPANMRFEVTLFEALVEGYLGSEIGPVLNATERAHLGFAGKLMTYETALRFLTDYLQGDVYFKTQYPDHNLVRARTQLALVRSITAQTDAVNSILESHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK53</accession>
    <name>A0A139SK53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712467.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34962">
        <property type="protein sequence ID" value="KXU34962"/>
        <property type="gene ID" value="AXK12_06230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="179" mass="19418" checksum="819C750C6C55FA79" modified="2016-05-11" version="1">MSLALATLIPAALLLVLGLALLSGRAMVAALAKQFPRSTAAALVFFGGAAAWFLYRVWHLPEADFGNHRTLLAIGFGAIAALSFKYVPDFLAVRGLAILVLLSASPLLGAAYMRYEAPQRLFMVSLVYLAIALALYLGAVPYRLRDFVEWLFVRPTRSRVFGALLVSYGALLSYVATTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK57</accession>
    <name>A0A139SK57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712624.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34933">
        <property type="protein sequence ID" value="KXU34933"/>
        <property type="gene ID" value="AXK12_06710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="166" mass="18427" checksum="A7A8C0DC3A8F4DAB" modified="2016-05-11" version="1">MCGGVFFSGGCSADEGASAAAVPKTGADWFELSVGGQPLRVQLALTPSEMQRGLMERRDLGADEGMLFVYVRPDQMSFWMRNTPLPLDIGFFDAEGVLREIYPLHPFDERPVRSRSLRLQFALEVNRGWFKAQGLAPGAQLDLSALTAALRERDFRPNQFGLKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK73</accession>
    <name>A0A139SK73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">AXK12_06225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712490.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06225"/>
    <dbReference type="EnsemblBacteria" id="KXU34961">
        <property type="protein sequence ID" value="KXU34961"/>
        <property type="gene ID" value="AXK12_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="153"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="475" mass="52466" checksum="EEC0A3AB12B22B4E" modified="2016-05-11" version="1">MNRVYIKTYGCQMNERDSEAVAAMLRGRGYRIVDDENACDILLLNTCSVRDAAEQKALGKAGYAAARKKRQPDFVIGILGCMAQNRGAAILDTLPDVDLVIGTQKFHQVPGYLDNLRAAREAGLPIGASIVDIAEEAGSQNTIRDHLDAEAGAAPQVSAFVSIQQGCNMDCHFCIVPKTRGDERSRPMEAIVAECRSLASKGVREITLLGQIVTSYGRRDYRHTDGVSPFVQLLEKVHEIDGIERIRFTSPHPRGFKDDLVAAYARLPKLCEYVHLPMQSGSDRILRAMNRPYSRERYLKIVEALRSARPDMYFSTDIIVGYPGETEADFEQTRELFESCNYDMAYIFKYSVRSGTVAAELADQVPEAEKERRNQVLLDILHRNSEQRTAALIGTTQEVLVDGPDKTGRRFTGRTRGNRVCIFDADPRLIGQLVPLHIERASVSTLYGSLVLAGVSDRAGETHSAPRAAPASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE0</accession>
    <name>A0A139SKE0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_06190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712453.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34954">
        <property type="protein sequence ID" value="KXU34954"/>
        <property type="gene ID" value="AXK12_06190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="193" mass="20328" checksum="E7CDD008D590C18D" modified="2016-05-11" version="1">MIKNFAQAFLPLFVAVDPIGLVAIFLALARGTARPQRQRIARHALLTGGGVALIFLFLGKSIFEAIGISVSDFQVAGGLILFILAARDLIHSTSELPETLSEGFGVVPLGMPLIAGPAMIAALLLLTHTVGLWMTLAALISNLGIMALAFAYSDWLGEKIGQTGLRAISKIVSMLLAAIAIHMIRIGALESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKH9</accession>
    <name>A0A139SKH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00315"/>
    <dbReference type="EnsemblBacteria" id="KXU35045">
        <property type="protein sequence ID" value="KXU35045"/>
        <property type="gene ID" value="AXK12_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="436" mass="49265" checksum="835D8E6829D70C8F" modified="2016-05-11" version="1">MRKILIVSPHFAPVNTADMHRVRLCLPWLRDHGWEPTVLAVAPESIEGAVIEPLLEKTYPKDIRIIRVRGISPKLTRPFGIGSLWLRCGRALRKAGDALLSTEAFDLVFFSTTVFNSFSLGPHWLRKFGIPYVLDYHDPWINDYYDLTGAAPPGGPLKYAFSQWQAKRHEPKAVLQAAQIVSVSSSYGPELCRCYPTLSPEKIHHLPFGASAKDIEVARSHHPMPSLVPFGDGNVHFVYTGRVDTDMAQALRMLFRAFALYKRNSPSEAAHMRFHFIGTDYAPPPLGRKHVMPIAQAEEVADHVTEHCYRVPYFDALSYLCHAEALILIGSDDPSYSASKIFPYLFAQKPIVTIAYQKSLMLKLSREFGHATSYDFSAKDTEENTQATIQKIHDEWFDNEGFRSPSLSLTQDSKLDSHSAQKMTRDLCQVFEKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKM5</accession>
    <name>A0A139SKM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_00325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712406.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00325"/>
    <dbReference type="EnsemblBacteria" id="KXU35047">
        <property type="protein sequence ID" value="KXU35047"/>
        <property type="gene ID" value="AXK12_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="508" mass="56699" checksum="10C4C37D6C26D01A" modified="2016-05-11" version="1">MTAVAARRQPPSFVADKSPRLEQLTVLHVVVLLIATTWLFGGNAGWVKPYLAAWASLSLPLFVLNLREIADLRQKTQILSQHYESTHTVRAPSPSIRSLLLCLCPLLALNTIVAVSLLFPGFRTFLFEGETLYISNRVATWIPSAAYPPAVGITLWLFNGAYLSAFNLLLAPKSRRTLRRFFFIALSNALLLAVFGTFQKLSGAKGLFFGLVRSPQERFFSSFIYHNHWGAFCVLTLALSLGLFAHYLRRHLLRDLTRTPAMYVLAVVAAAAITTPLSDSRSGTVLVLLALLVGTIHALVVFWKRHDGPPARRPLPAVLATVTFAILLFIGYDLAKPQIADRLRQTQGQFSGGKKVLIDHRLTLYRDTYHMARDRLLFGWGMASFPHTFPIYNTQTYGATLGIPFLYHDAHNDWLQTLAEFGVVGSSLIALCGLAPLLAFRKTIRANPISAYLFGGCALILLYAWLEFPFGNTAVRLTFWVFLFAAIRYAHLTYTEHTASLRAPHHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX4</accession>
    <name>A0A139SKX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35199">
        <property type="protein sequence ID" value="KXU35199"/>
        <property type="gene ID" value="AXK12_05705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="60" mass="6106" checksum="506DB1927C85FC86" modified="2016-05-11" version="1">MVGESGVAKVGFGEAAFLNHRAHRTAEDGDALAQERGIWGAGLSFGGRLHAASDRPGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ3</accession>
    <name>A0A139SKZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712161.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35206">
        <property type="protein sequence ID" value="KXU35206"/>
        <property type="gene ID" value="AXK12_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299290" evidence="1">
        <location>
            <begin position="26"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="299" mass="33032" checksum="376233BC89F4133E" modified="2016-05-11" version="1">MKKCLPQLLLVLALLLSPSAPTLFAQVANASEIPPPVAELQALMKEFETRAESEGQESSALADEFFERIDQLLEKYAADRSEGVAHVAATRAFMLFRLRGDAERVRELLLAIPKDFPGTQVAAHIPTTLKQLDEAIAQISSWRAPDSILLTIGQRRTGEIVTREGRDGLIKFPSTDKYSFVVREAGEYVIEMNSDKIDSGLPGPFRDMIERSSDKINCGLRLLRGDGTLIAEDGTRHQRKSAEESEFFASLLDDDHIYGLYDLGPDASIVRYLTPGGYVIEASSGNGNTGSYQIEVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL49</accession>
    <name>A0A139SL49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712040.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35289">
        <property type="protein sequence ID" value="KXU35289"/>
        <property type="gene ID" value="AXK12_05415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299259" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="141" mass="16091" checksum="98C977A37A8D4FE2" modified="2016-05-11" version="1">MTPRFLPLVFVLLGALPLVFAQEQEPEAGGESGEYANPVFGYYEAIRFDAQMLQGVRVNEETGDVFIMFQPDKTDTQLTLKISQAEGAQYRKWFTGEEVLVAQENAGRAINTWTDRVQTSANYIEYHAEGRIFLHLKRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL65</accession>
    <name>A0A139SL65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712058.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05470"/>
    <dbReference type="EnsemblBacteria" id="KXU35298">
        <property type="protein sequence ID" value="KXU35298"/>
        <property type="gene ID" value="AXK12_05470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025738">
        <property type="entry name" value="BatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40940">
        <property type="entry name" value="PTHR40940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13584">
        <property type="entry name" value="BatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299297" evidence="3">
        <location>
            <begin position="28"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="876" mass="93697" checksum="E1BB5A5EE56543DC" modified="2016-05-11" version="1">MRFPLHLFPTLAALLFCTLAALPEALAQRVFWADSGTGDPADIQLVFENCSPSTAPSLPELTEATLNYRGQSSQTQIINFSRTSLVVLSYRLQIRTPGQVTIPSFAVQTNEGELSVPTYTTGSVQPGPEADIKARLTPRKTTVWAGEVFPLVYSIDVARRHFSNFAEAIQWDAAPLVAEDWADPAATESMQSGESRLHIGFATRAYAQAPGALRLNPVRQLVTLNLGLAPGGFGFFQQQRLEQVTLTTNQAELNVQPLPLPAPANYIGAVGDFTLESKVVPQAGTVGEPITWTLTLSGTGNWPDIAGLPPRTVSADFQALQPPAKRKLDDKKLFDGTLTEDVVLIPTRPGTYTLEAFEIHTFDPESGRYQTHHIAETTITVTAAPTAAGSTNVGSPTSVTHSEPSPPPDAAARLSGTAPVLEPPEIAEPPQGLIREPIATGRLARLPADSLGQVATRAAIPFGAVLTTWLALAVRRARKHDPLRPRREALAQVPAAIAALRENQNSAQALLTWQRFAARAHGLAHAAPTVSEFPEGQWRALWADSERALYREKTPLPSDWLARAEAAHASLAKEIPGTAWASAFRKANLLPWLTALALALVVNPHSAHAGDASDRRRGDDPAPNKSGLAPADSALPANANQHAQAAYTAGDFVEAEALWRATIAAQPSDWTARHNLALALAQQDRWAEAAAHATAAFVQNPKSEVTRWNLALAQSKAGYTPAEIAPALGDGLRARFAQLASPSGWDCVIIGGASLVALALLLPLLRAYGLLRRAINPPALVLGICGILLAALALFGRSHYGLAAHPQAALVWRTGTLYSIPTEADITQQSAPLSAGTIGITEKTFLGWVQLRFSNGQTGWTRDTELVRLWTAASDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL77</accession>
    <name>A0A139SL77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ORF">AXK12_05950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05950"/>
    <dbReference type="EnsemblBacteria" id="KXU35240">
        <property type="protein sequence ID" value="KXU35240"/>
        <property type="gene ID" value="AXK12_05950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="273" mass="30183" checksum="0D7F93B94F9656F1" modified="2016-05-11" version="1">MKKDHNIFSDSAAEAEVLRGKPMGFFDHLEDLRWTLIKSAAAFLVFAVLIGLFMRRFNEVLLWPLRSVQAGNPALQLDLGTVSIMEGFTVVLQMCFMGGIVLAAPFILLFVGQFVSPALTEREYKVVLPLCVAAMVLFLCGACFGYFVLVPSTLAVSVGLNEYFGFVMRWTPGSYYGLLTWLVLGVGASFEFPLLIVLLVYLGLMTTATLTKYRRHAVVAIFVIAAIVTPTPDFVTQTLFAAPLYLLFEAAVLVAKRVERRREAMMRGEAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL82</accession>
    <name>A0A139SL82_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05550"/>
    <dbReference type="EnsemblBacteria" id="KXU35312">
        <property type="protein sequence ID" value="KXU35312"/>
        <property type="gene ID" value="AXK12_05550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="971" mass="104687" checksum="2E9682E317214D04" modified="2016-05-11" version="1">MRRRTAFLLLLGLAAVFRMQEGEAQPAERSEPLHLPTPFVGAAEGGEGQALATGAEASAGEVALDLMAAQRALRLGFPSAAVVLYRDLLQSASVRSGARPDDVHGAALAPERSSTPGGSSPNAGGDRLPPDGKGLGTEFSKMLRLGLVTALMDDGRFAEAAVVLGEVPEAERGAQWRLRAGLLAAARRDFVEARRLVGSFRPDELPSEERAWALFLQGVLADAAGSAGAARSFFEQAESGAASPEAQARFVLARARGLLRVGEVSEAAAAEARRNMERLRGRTAGLHFARTYAAMLDALGRKGEAVAVLQQQLMALPATLRGERDDFQLLLGLIAGAESGPGRVALRNLVASGSDPAKQRAGLHLLAQVSAGEGAGGMGGVGQLERDLDQLLEASPAHPILDDLLLVRAQLALSAKRYAQAERDARALLEKFPGSQRKAEAYGVLMSCAWEQFRYRASADFAAQAAAALGAPPHASGAPPHAGEAISLQRFSLGVLVAEAWFRARDYLNAADAYTAVIRDLLPPSGEVAPSLLIASVGDLMFQRVLSEIEAGRLATASEVLNELAADSRFDAVSRWQAEWNLARALQREGRMVEAYERVSRLVAEDSAGDASAASRTPSALPPELQARMRWLQARLSLLAGEPEETLRLADALIEWMPEGVGEALAEELRSSCALLKAESLFRLGRREEAVALLQEVREASARSNAAVQSLIVEAGYYAGQGQTVEAQQLYTKLADDFPDNPTYAPYGRYQAALQAERRGQDANLEEANKLIEQMVTRYPQSPLVFYARLKQGDLLRKLNQFPQAQQVYESLLNNYPQHPDVLLAQLALAECHNAQSMNDSAHTGRALVLFEQLRDRVDAPVDVRVEAGLNLGHLMLRGGQADQAEAVWWRDVVTAFLLDERMASQLGVRGRYWMTRTLLELGALYERQSRLDQAREAWALILKTGLPGASLAEDRLARTGGDQRLSALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL90</accession>
    <name>A0A139SL90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KpsF/GutQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712110.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05595"/>
    <dbReference type="EnsemblBacteria" id="KXU35321">
        <property type="protein sequence ID" value="KXU35321"/>
        <property type="gene ID" value="AXK12_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="327" mass="34664" checksum="1FCBF9DBC4F0E05A" modified="2016-05-11" version="1">MAVTSKTILSRARSCIQIESDALQETAKNLGPEFVQTARAVEATLESGGKLVFSGVGKSAHIAQKLVATFNSTGATSTFLDATQALHGDLGLCRTGDLAILLSNSGQTEVLRLVPLLRRAGLGLVAFTSRADSDLAAHADQLLLYHVPREACPLALAPTASTTAALALGDALAMVLLQARGFTRDDFARNHPGGNIGALLVRVRDLMRTAERAPQLPHTATVQDAILAMTKAKSGAIALVHPRSGRLSGVLTDGDFRRSALSGPDFLTQPVSRFMTRRPKTIRAEAMGVDALELFEKHQIDDLIVVDAQGKPIGIVDGQDLPKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLD7</accession>
    <name>A0A139SLD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711959.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35373">
        <property type="protein sequence ID" value="KXU35373"/>
        <property type="gene ID" value="AXK12_05215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="77" mass="9211" checksum="D4E71091CBD12CF1" modified="2016-05-11" version="1">MTRTTSTTTPSKTTDAPSRDFVKKSSLYQEFLAEREEILKHKWLESERLGYDIGFEHALLDWIRKHRESWRATRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLI0</accession>
    <name>A0A139SLI0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05330"/>
    <dbReference type="EnsemblBacteria" id="KXU35409">
        <property type="protein sequence ID" value="KXU35409"/>
        <property type="gene ID" value="AXK12_05330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="399" mass="43907" checksum="312FC1768783412D" modified="2016-05-11" version="1">MPFRPHTRSRWDWLSPLACAGLALIGVFFIYSAQLPVHGRNWITQLVWLAMGGAIYLGVSLIDYRFWLSVAHWFYGLALVPLLLVLVPGVGSERFGAQRWLEIGPFTYQPSETAKVAVLIMAASLLVRERIGTVRDSLGVLGKLALAVGLPLILILLQPDLKSAIVLPPMVFAMLFVSKLSARFFAGALAAFLVIVALVSWDTWRYASFMEAHGYSYLRDRGKFEAQTWVPLHDYQRNRIISFVAPDKIDPMGIGWNQRQSLISVGSGGLTGKGWTQGTQAQLGYLPRSVAHNDFIFSVIAEEKGLLGSFTVLSLFGLVLFNGIRIAGLARDRLGTLIAVGVTVLFTVHVFVNIAMTIGLVPITGIPLPFISYGGSFVLSCCLLQGLVQSVYRFRKDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLI3</accession>
    <name>A0A139SLI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05190"/>
    <dbReference type="EnsemblBacteria" id="KXU35407">
        <property type="protein sequence ID" value="KXU35407"/>
        <property type="gene ID" value="AXK12_05190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="341" mass="35360" checksum="F5A2A779BBDA1CA2" modified="2016-05-11" version="1">MDLLAHVDDSFLREHVSGEKGGMVLVEDADIAELVAKLPSLATVPGGAAANTTLAAARLGLSTAFLGKVGSDDTAAQYLANFREHGADTARFKQHPALPNARCLSLVTSDGQRTMRTHLGAAMTLAPEEISPSDFAGVRHAHIEGYLLFNPALADAILSAARAAGCTLSLDLGSFEVVSVARKWIFRQLEAGIDIVFANEDEARALFADNPEQTQKGSPDEGSALAASESTPDKQAEALARFGGIAAVKIGAEGAWLAQGDSLHRIAPAPVSQVIDTTGAGDAWAGGFLYAHLRGAPLPSAGALGSLLGAETVQCLGAAIPADRWPEIRAKATELLTQHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS3</accession>
    <name>A0A139SLS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711917.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05110"/>
    <dbReference type="EnsemblBacteria" id="KXU35502">
        <property type="protein sequence ID" value="KXU35502"/>
        <property type="gene ID" value="AXK12_05110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="356"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="643"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="808" mass="89495" checksum="D99EC12043DC09D4" modified="2016-05-11" version="1">MGGSVSLVFHLPPNLIQAAARNAVPLRIEFDLTQAPAPQVLPALALLQRWSGNASEPPRLIQLSRAQLRELLAAIGTQPLFIYNGERSPWPMPGLLKEPEERKPAAPAKKREPEPISALAHDGSGLLDGSEHFLAITPPPRDHPCYRSLLTFLKNNSFTLEPSNRRWWLRDRHKVLNLLATQGRRLRDNFDLEETPNFTQRTAHLRDAEVQAAVHEEGGDFILDLDLAAGGAPESEVRAALATGRHYIEHGGRIYLFDEAKLAKLAEAQRALNTHSAAARQATTPAAHTALKISRERIPLAQDILDELAPGFRPSDEWQRRSRALRELSTLPPAPLPDQLRDTLRPYQRLGVAWAWYLRNQGLGGVLADEMGLGKTLQALALLAAIASETTKPKIVVAPASLLENWRREVQQYTPQLRVFVHHGANRLRRVDDFAPYDLILTSYGTLSRNRKLFAQVEFACAIADEAQHIKNRHSQNASSLRALRADTRFVLTGTPLENSLDDLRSLFAFLMPGLIPALPLGAQAEDRAWHDVQTRHVTAPYILRRTKAAVAPELPQKIEQTIWCEPTAAQAALYRYWQEKTERELLDLAASGANEGRLHLATLTQLLRLRQICCDPRLVPTETGAPASTGALSISDSAKFAALRELLEEAIDDGHRVLVFSQFTSLFALLRPELDALGIAHAYLDGSMSATERQHEVDRFQSSPDIPVFLLSLRAGGTGLNLTAADTVVHLDPWWNPAVEAQATDRAHRIGQTRTVTSYKLICSGTVEEKVLALQDEKRAELADVFEASDAANARLSIDDLRSLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM18</accession>
    <name>A0A139SM18_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35613">
        <property type="protein sequence ID" value="KXU35613"/>
        <property type="gene ID" value="AXK12_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="161" mass="18115" checksum="B5C6FEB5C8478E47" modified="2016-05-11" version="1">MLGFVIGAVFVLSLRRDPEVVYVREEVALPSPSPAAAAPPQEPDFTVLEAVFAEWQSYAVWDADVTEVALWDSDLGRYARFYEVLRAPSREGVAGGALTFYYRSIPALTRPVVTRGVSESLPLLFTEPDVLREAWLRQRDEETWSAIQESIRKLSAPRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM42</accession>
    <name>A0A139SM42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ORF">AXK12_04955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711859.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04955"/>
    <dbReference type="EnsemblBacteria" id="KXU35602">
        <property type="protein sequence ID" value="KXU35602"/>
        <property type="gene ID" value="AXK12_04955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="142" mass="16105" checksum="91B91D045DF59730" modified="2016-05-11" version="1">MKTILANKETVQPTWHLIDAEGQVLGRLAVKIANLLRGRHKPIYTPHVDTGDFVVVVNAEKVVLTGKKEEQNEYMFFSGYMGGESRRKLSDMRKQRPEFILQHAVKGMLPKNRLAAKMLTKLRVFTGPNHTHEAQAPVKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM50</accession>
    <name>A0A139SM50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ORF">AXK12_05020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711878.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05020"/>
    <dbReference type="EnsemblBacteria" id="KXU35612">
        <property type="protein sequence ID" value="KXU35612"/>
        <property type="gene ID" value="AXK12_05020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="155" mass="16379" checksum="550E2D1E97B84C99" modified="2016-05-11" version="1">MSDAFASPASVRAALLSGLSLPAGGVLIGLGCDLIEVERIAAAISRHGVHFLTRTFTEEERSYCAALKYPDKHYAARWAAKEAVAKAFTTGIGAELSWTSVSVYHGARSEPRVRLDDQGASLLRALGGTDVLLSLSHTETHALAVAAIVRKECAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMA7</accession>
    <name>A0A139SMA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711820.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04860"/>
    <dbReference type="EnsemblBacteria" id="KXU35649">
        <property type="protein sequence ID" value="KXU35649"/>
        <property type="gene ID" value="AXK12_04860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="366" mass="38961" checksum="205BF29BA6D295E9" modified="2016-05-11" version="1">MNESAYACIMAGGSGERFWPLSRRARPKHLLKLFSERTLIEEAVRRLEAVVPLAHIFVLSNEAQLEATRAALPFLAPEQIIAEPAKRDTAAAAALATALVRSRDPEAVMALLPADSLIKDSATYARQLSGALARAATSDALLTFAIKPSSAATGFGYLEMAEGLGGGFRRVARFVEKPDAATAAQYVASGNYAWNAGMFIWRVGAFLAEAERHTPALATFIREFPNCESSALSEGASVAQAEARAAFLAERFPTLEPRVSVDYAIMEKARAVETLVAEFDWDDVGSWTALPAHLGEDEAGNCVSGAGVALHGARGNIVFGSSGRTVALCGVQDLVVVETADAILVAHRDSVQEIKQVLPKVPPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMC9</accession>
    <name>A0A139SMC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711757.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04690"/>
    <dbReference type="EnsemblBacteria" id="KXU35669">
        <property type="protein sequence ID" value="KXU35669"/>
        <property type="gene ID" value="AXK12_04690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="27579" checksum="22E9B14479D60230" modified="2016-05-11" version="1">MATTTIHPTAIVETGAVLGAGCEIRAHAIVTRYCVLGEGVVVHPFAVLGGEPQHLSFDAAGVESRVEIGAGTVIREHVTVNRASVAGGATRIGAGSFLMAASHVAHDCSLGEQVVLANAALLAGHVSVGAHTFLGGGAAVHQFCRIGESVMVAGHASITRDVPDFLMVAERDEAIALNTVGLRRRGISHEAIGELKRAFAIVFFTPGNIREVAREALNEGEPSCWTSAEARQFLAFFAEGQRGFVRARRQGRASQHEQEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMD0</accession>
    <name>A0A139SMD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">AXK12_05070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711894.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05070"/>
    <dbReference type="EnsemblBacteria" id="KXU35620">
        <property type="protein sequence ID" value="KXU35620"/>
        <property type="gene ID" value="AXK12_05070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="6"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="405" mass="45642" checksum="36F974AB0BF9D9E4" modified="2016-05-11" version="1">MKIVLAYSGGLDTSVIVKWLKETYDADIVTFAADLGQEEELKGLAQKARKTGASKHYTLNLVEEFARDYIYPMLRANAIYEGQYYLGTSIARPLIAKAQVEIAKKERADTVAHGATGKGNDQCRFELSYMALAPELTIIAPWKIEAYRDAFPGRAEMIAYCRKHKIPVEASLKKPYSMDRNLLHISYEAGILEDPWFDPTTEENKAMFKLSVSPEDAPDKPEYVELDFAKGDCVAVNGKKLSPGGVLKALNKLGGKHGIGRVDLVENRFVGMKSRGVYETPGGTILMHAHRQVESLTMDREVMHLRDSLIPKYAELIYNGFWFAPEREALQALVDNTQRYVTGRVRLKLYKGNIITCGRRSKYSLYDENIASMEGVQSWYNQDDATGFIRLNGLRLRARHLAKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMH5</accession>
    <name>A0A139SMH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">[Fe-S]-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711759.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04700"/>
    <dbReference type="EnsemblBacteria" id="KXU35670">
        <property type="protein sequence ID" value="KXU35670"/>
        <property type="gene ID" value="AXK12_04700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="137" mass="14107" checksum="23E8B39F05F71F88" modified="2016-05-11" version="1">MTATVATAPLQSPTVSAVPASVATPREGDERLVCLTDAAGEKLRALIAREGKGEFLRVAISGGGCNGLSYKLRFVPAPKAGDILVRSAGVAVLVDSKTALYLRGTELDYSAKLIAGGFRFSNPNAKASCSCGESFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN44</accession>
    <name>A0A139SN44_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04650"/>
    <dbReference type="EnsemblBacteria" id="KXU35975">
        <property type="protein sequence ID" value="KXU35975"/>
        <property type="gene ID" value="AXK12_04650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="735"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113081" checksum="091DEE5E9C6BAB3B" modified="2016-05-11" version="1">MEAVGELRQREAMAASQTGLRLRFFTWEKPLLGQAVEYLTASALAQRASAVGGNEVARLSVLRALDLSAQLVVVPTQQAGRRLREALAAGAAAQRATRLQVSASGEPAAAATYAAASRTALFPPLVLTFDALLEVLGEAGAGGGAVAGAGASAQIQHASPSQVLLAWVDVLLSAELEAFRAVFPGDPPARNFSWARGMAEQLASLQDELRENGLGLVEVAARLEPDFPEFARWQELAELERRQCARLADFGLAGPLEAQRELLAQGRLPAGIERVVVLAWPDPRPMVLGFLERVAQVLPVEICVYAAESERDHFDGWGRPIPEKWAARELQLPDFAARVRVCADPHEQAERLADTAALYTREGANAAQGSLALGVLDAEILRPLETALRERGVPSFNPTGSDRRGDRLHQLLCALAAFAREDSFQNLARLARQPDVLLALFGATEGTRFLAELDGVYERHLPPDLSALRAKWRSVDRAGTAALKRLGEWREVLRRGDFSAAGQAVLAQIFQGRSFDLSVPEDAEWVAAAEVWAACLREVAEAVRLCPALGGDERFASAVGGEREGGEAFLALAIECYARKRVFGEKPAGAVELQGWLELIWADAPHLVVAGLNEGKVPASVSGDLFLPESLRAKLGLKTNVQRFAVDAYYLQSLAASRVGAARLDVLFGRVSAKGDPLKPSRLLLRCEEEDLPQRVQFLFREPPPRGGAALAWSRAWTLQLPDPSEVELPLHLPVTGLRAWLACPLRFYLSRVLKLRPVDAAKVEMDARDFGTLCHAALEAMGREEALRGCTDALRLQRFLREALDAAVARQFGRRLSVPLRVQVESARQRLDALAVEQARLHAEGWRIKRVEWEFELPIGELVFRGKIDRIDEHEASGALRVIDYKTSDTAESPERVHLVSLPKGAELPAWRLFQAEEGKKPRAWADLQLPIYERVCAGEFSGRPLRCGYFNLPRAVADTALSLWEDYTQELTASAWGCAVGVAAAIARREFWPPRELKPWEARRDEFATLFQRGAADSISFARKGEEAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN57</accession>
    <name>A0A139SN57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711480.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04035"/>
    <dbReference type="EnsemblBacteria" id="KXU36008">
        <property type="protein sequence ID" value="KXU36008"/>
        <property type="gene ID" value="AXK12_04035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="334" mass="37528" checksum="2308AD680E908829" modified="2016-05-11" version="1" fragment="single">MAYDWLKGVDDEYDVIVIGSGLGGLTAANTLAKAGHRVLVLEHHYQFGGLATWFTRRGGHIFDISLHGFPSGMKKSCRKYWTQEIADSIHQLRDIRFINPQMDVRTTFTREDYTRALVDQFGVPCEQVEAFYDHLRQMNYYDNNPETTGELFERFFPGRADVHRLLMEPIAYANGSTTEDPAITYGIVFSNFMGAGVYTFQGGSDTLIKKMVEELKRNGVECRKRVRVKKIVVEEQRDEATGKVIRRAVGVVAGHHDRVIRAKAILSNANIKNTIFRLAGEENFAPDYAAAAEAVRLNTSSCQVYFGIRAGESIPHIGDLVFTSDAPRYSSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN61</accession>
    <name>A0A139SN61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04670"/>
    <dbReference type="EnsemblBacteria" id="KXU35979">
        <property type="protein sequence ID" value="KXU35979"/>
        <property type="gene ID" value="AXK12_04670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014469">
        <property type="entry name" value="DUF2271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10029">
        <property type="entry name" value="DUF2271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014995">
        <property type="entry name" value="UCP014995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299373" evidence="1">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="172" mass="19017" checksum="45909A38832AB782" modified="2016-05-11" version="1">MPMSSIIRKNLLCLAPGLAVAGAASASELTATVELPRLNVAEYHRPYVAVWLEGPDKAHHNVSVWHLVRRNDDTWLKDLRQWWRKSGRSLEMPMDGLSGPTRPVGVHEIQVPVALTESLTEGAEYTLQIEAVREKGGREVVSVPFTWSKAQALDITASGERELGAITLRQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND8</accession>
    <name>A0A139SND8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711484.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04045"/>
    <dbReference type="EnsemblBacteria" id="KXU36010">
        <property type="protein sequence ID" value="KXU36010"/>
        <property type="gene ID" value="AXK12_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="85" mass="9649" checksum="C9ABC78FDF421177" modified="2016-05-11" version="1">MTKDECKQVVIEIIADIAPDEDLSNLKPDLRLRDQLELDSMDFLDIVMELRKRHGIEVPEADYPELASLDSCAEYLTPKFAALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE2</accession>
    <name>A0A139SNE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711648.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36087">
        <property type="protein sequence ID" value="KXU36087"/>
        <property type="gene ID" value="AXK12_04520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="25066" checksum="28F7036CF43322EE" modified="2016-05-11" version="1">MLIWIILIIVPMLFGLYAQTRVRSAYNKNVRIASRGRITGREAAEAVMRSAGVQGVEIIKVPGELTDHYDPIRRRLALSEMNYHGTSLAALGVAAHEAGHAIQHKVGYSMMKVRQTLVPATQIASSISSYVIMAGILLLSFAGSAFGYNLLALGAWALGVIVVFQLVTLPVEFDASRRAKAQLVTLGIVEKDEMKGVHETLDAAALTYVAAFVAALGSLLHILLILAGGRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE4</accession>
    <name>A0A139SNE4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">AXK12_04460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711626.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04460"/>
    <dbReference type="EnsemblBacteria" id="KXU36076">
        <property type="protein sequence ID" value="KXU36076"/>
        <property type="gene ID" value="AXK12_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="321" mass="35228" checksum="73DDAF0BCE72C1B7" modified="2016-05-11" version="1">MSSPKRKVSAARRATFSSAAPGDFAEDIDRFLSYIGLERGLSPNTQEGYLNDLDQCAAFLAKRGTASDWRSVSGGEVALWIQSLSGADYAVASLARKLAALRGLAHHLVRERLREDDFSALLTAPKHRRQMPGTLTNEEVERLLAAPSGGDPQSLRDKALLELFYSSGLRVSELGALTLQQIDLEHGFLRVFGKGSKERVVPVGSKALTAIARWLEAGRPYYVRTHTGSQLFLSARGRGLSRVTLWVIVKKYARLAGITKPVKPHLLRHSFATHLLTGGADLRAIQEMLGHASIATTQIYTAVEPQRLIEGHAKYHPRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNI8</accession>
    <name>A0A139SNI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711399.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36193">
        <property type="protein sequence ID" value="KXU36193"/>
        <property type="gene ID" value="AXK12_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="354" mass="38049" checksum="3FAC11ABEE4E04F0" modified="2016-05-11" version="1">MNSTVNANSSPKPVRILIVGTGGMAHQHVWAYQKISAVRLVAAVDINPERLRTFAQKYEIPQTFGSVEDAVAWGQFDAASVVTPDGLHYAATLPLLAAGKHVLCEKPLASSARDAVEMAEAAARAGVVNMMNLTYRNEPTMQKAAQLVREGALGEVRFFEASFLQSWLHQPAWGDWKTESAWTWKLSTAHGSRGALGDAGVHILDYATFIVGQEVVEVAGRLQTYNKAPGGRVGEFTLDANDSAIMSVACTGGSIGTIIATRAATGHLNDMVIKVYGETGALDLRYRLGESELHACLGAANVLHGKWEPVDCPAVTYPSNYERFVAAIRGETSPEPDFARGAALQKVLDRAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM7</accession>
    <name>A0A139SNM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeoA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36187">
        <property type="protein sequence ID" value="KXU36187"/>
        <property type="gene ID" value="AXK12_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="79" mass="8316" checksum="A371833F8494543E" modified="2016-05-11" version="1">MPLCQLPAGERGRVLTLAGDAPFCQRVREMGFGEDAVITKLSGSATILCQVGETRLALSHEAARRIRVQVIGPSHSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNQ2</accession>
    <name>A0A139SNQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711670.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36100">
        <property type="protein sequence ID" value="KXU36100"/>
        <property type="gene ID" value="AXK12_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="577" mass="64883" checksum="0ADF7D5447923ADE" modified="2016-05-11" version="1">MARSMLAHNIDSIQPNGTVLPVPGEQSRSDEPGHVAFALGEYYRNTGETTLGGHDLIDLAARCITAQMFTEPAAENGLAYAALGLLAFGPSKERNPIWERLVDETKERIDKQLLHRSDYDNHWQSFNIAKAVARFSLGLSKKDETSRLIERMVDRVQHTSSTGFFDDAAPGLGGHFNLYGVLAFVFTRSALQLHANSGVRDRKLPTLRTYAEKYIKMMPDLVRADGLGWAFGRAAGAYGQMHCISLILQGLRDGWIADTDKPKYFDILRRLFLFFYQTYLDQEHGFLDLRDDERTAYEPHTTRIANFDAARYLCQWSRLAQTVQMPAGAAAQVPPQGNSGRFVVFDKSNRKEQGVFLFRDAASGLHAQIPLISAGSTVTSDSLPFPHCPGVFDWPNNVYMPVMVPELTFGDKVTTPAFYGRNCVTGLGLRNSFFFRYEQPDLITTEEEILKGLGSVKVQWNFSGRQISCEYAYTVRQQVTLNRFRYMLVIAAPHSQYRVGGSLALGTEGHRCTVSKNDFQANWAETEVVSTDPNYRTNYGKIHYVQTLLRDHPLIMRPGQVYRLAVNFDPDVAQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNQ6</accession>
    <name>A0A139SNQ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">msrB</name>
        <name evidence="5" type="ORF">AXK12_03875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711429.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03875"/>
    <dbReference type="EnsemblBacteria" id="KXU36209">
        <property type="protein sequence ID" value="KXU36209"/>
        <property type="gene ID" value="AXK12_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="17200" checksum="80962D0A4CC94B83" modified="2016-05-11" version="1">MSKVSVRRTEAEWRARLTPEQYRVAREQGTEPPFRGAYWNHHDDGVYFCVGCDTPLFDSAEKFDSGTGWPSFYRPIERAFVATQKDFSHGMVREEVHCAVCGSHLGHVFDDVPHKKGRRYCINSASLRFMPRAEYAAWLEKRALDELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNQ7</accession>
    <name>A0A139SNQ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SufBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03590"/>
    <dbReference type="EnsemblBacteria" id="KXU36233">
        <property type="protein sequence ID" value="KXU36233"/>
        <property type="gene ID" value="AXK12_03590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="3">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="467" mass="51423" checksum="8FCF62BEE3D65313" modified="2016-05-11" version="1">MPLPDLENPHLAKHSVSTRAAGSEPHIDTEPELPEWWLAAKQAAWERFNELPLPTRLDERWRFSKLSGLALDSYALTREERAAQTMSQRAHHPMEEEAHETPYQCPTLPPFERAATLCFHGQTLVHGVELPEELAERGVIFEPLTEALATHGDFLRDYFHKYPTELGSEKFTALNTALTNTGAILYVPAGVEIAEPFLVEHSVEGEHAAAFPHTLVILGERAKATLVEHFTSDTEAPQLVSAVSDLHAAAGAQLTYIGVQDWSPAALALHSSAIAVERDARVLSINLHLGGAQVRHESHSRLLAPGAHSDMCSLSIAHGHQEFDQRTLQTHAAPNTSSDLLYKNALLGHAHTIFSGLIVVEPDAQKTNAYQSNRNLFLSPDAHADSLPGLEIEANDVRCTHGSTSYRIDPEQLYYLLSRGIPPAAANEMLVFGFFEEVLNKLNDTHPALRDALSTFTQQKFKATQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR1</accession>
    <name>A0A139SNR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711310.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03560"/>
    <dbReference type="EnsemblBacteria" id="KXU36227">
        <property type="protein sequence ID" value="KXU36227"/>
        <property type="gene ID" value="AXK12_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="139" mass="14680" checksum="F3123BBF7AE526A6" modified="2016-05-11" version="1">MKFLNLKFIPQSADLALLIVRVLAGFTLIYAHGWKKLAHFNDTVAQWTQWGLNPIGVGPTASVALSGFAEVVCAALLILGLKARFAALVIGINLTVAFVAVHKAALTGDNNGELAFMYLLAAVLVLFAGPGKFSVDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNX6</accession>
    <name>A0A139SNX6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">AXK12_03530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711300.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03530"/>
    <dbReference type="EnsemblBacteria" id="KXU36222">
        <property type="protein sequence ID" value="KXU36222"/>
        <property type="gene ID" value="AXK12_03530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="558" mass="61658" checksum="78DF299DC576E925" modified="2016-05-11" version="1">MQAPPVTKYRAFPPIHLPDRQWPSRSLDRAPAWCSVDLRDGNQALAQPMSVEEKIDYFAMLVKIGFKEIEVGFPSASQIEFDFVRRLIDEQLIPEDVTIQILCQCREDLISRSLESLQGARRAIFHLYNSTSPKQRDYVFGATKAEIVAIATHAVGFLKEKMQPLVAGGTAIQLEYSPESFTSTELEFSLEICEAVSEVWQPTPTDKIILNLPATVEYATPNVYADQIEWFGKHLRHRDRSLISLHTHNDRGTGIAATELGLLAGADRVEGTLFGNGERTGNLDIVTVALNLYTHGIHPALDFSQINEIRDTYERCTKLEVPPRSPYAGDLVFTAFSGSHQDAIKKSWPKQSGEKPWDVLYIPIDPADIGRSYKAIIRINSQSGKGGVAYILEREYGLDLPKAMHREVGRLINTLADQTGRELTSQEIHAAFAAEYLDRAAPLAIQHFKSTETETAVRCEVSIKIDEAVHALHGEGNGPIDAFVRALASTALPKFEVLSYSEHSLGKGAEAKAVSYIQIKTAQGQTLYGAGTDTNIELASIKAIVTALNRSIAKTADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPB1</accession>
    <name>A0A139SPB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711254.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03400"/>
    <dbReference type="EnsemblBacteria" id="KXU36344">
        <property type="protein sequence ID" value="KXU36344"/>
        <property type="gene ID" value="AXK12_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="407" mass="46537" checksum="48DEABA211073870" modified="2016-05-11" version="1">MSKLRILVLTSSTGAGHDARAEAFAEWCFELYRHQVDVQIEQMLEKSSWVARAGVNLYNWIQKKSPWMHKVFYAVVEGLSLLNSRTVTLGRRYYLDVLREYRPHLVLSVHDCLNRGYFQLARAVLGQDAVRTATYCGEFSGGWGYSVNWIEPSADRYFSRTETANDYAVKKGMPRERTRVRGRLMRPREHLEVLGEAERRRFLTQQLGLRSGLFTVFLATGGNGANNHFALLPALLRHADKVQVILICGRNREAYNALIHWRANHPELRCHIEGYTEVMHLLMQVSDCIVTRGGTTTCAQALFFRCPIIFNAFGGVMPQEELTWKFFREGAASPKIETTDEFAALIDTWMADRASYSAVRERFHALRHDDDPTVLIDELVQLANEAARSTDLIRHQWPPSPESAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPB4</accession>
    <name>A0A139SPB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711286.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36362">
        <property type="protein sequence ID" value="KXU36362"/>
        <property type="gene ID" value="AXK12_03370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="524" mass="57773" checksum="34CE13833BE34411" modified="2016-05-11" version="1">MVSPHSSSPAPTPYAQLLSHLGRIHKLETIAQLLGWDEQVNLPKGSADLRAEQHAVLAETIHAAASDPELGALIARLAEGKGAAGDALSAEERLVVREAQRDYERATKLPVAFVRAKAAQSSVGFHAWAKARAEDDFASYAPVLERNLELAREEAAYLGWGGDPCTSASGEGGSRAYDYMIDKHDPGLSAAVIEGLFGELRAGLVPLAREISENDDGRAKAARARLRGFSINAQREFLDEVTRRLGFDYEHGRIDVSLHPFCAGTGADIRMTTRFNEDEPLDSLFSAIHETGHGLYEQGLPLAHHATALGKAAGMGVHESQSRLWENQVGRSRAFWAFFEPRFREKFSGPLRGVSSEELYLAVNAVEPTLIRVDADEVTYNLHIILRFEIERQLFSGALKVGDLPEAWAALSRELLGLEPKNDREGVLQDVHWSDGAFGYFPSYCLGNMIAAQLWEAVRAEEPEIEADFAHGDFGRLLAWLRKNVHAAGKRHDALDLTQRVTGKPLSPAPLLRYLRERYLPLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ16</accession>
    <name>A0A139SQ16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03170"/>
    <dbReference type="EnsemblBacteria" id="KXU36622">
        <property type="protein sequence ID" value="KXU36622"/>
        <property type="gene ID" value="AXK12_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="34990" checksum="CDF5833B39B2AC64" modified="2016-05-11" version="1">MLSSKIKNKAMSITPELSFFPWKPACWLRVQGPDAFSFLQGQFSNDLRGLAGGLGGDSGVSGGDEAAVFSALARAVYGLWLDRKGRILGDGFVLRVGEECFFICSYETSGAALRAHLESFIIADEVELFDETAEVLGLTFFLKEGVPFSLDLARAGRVFEGRRGARAIECVGPAAACAELIAQLNPKMELSAAEMERRRILAKVPAVPRDLGSADLPQEGGASFEQSAVSYTKGCYLGQEVMSRLRSMGRVRRSLVLVRSEGIAPSELPAPLYLGEKRVGEMRSVVADETPGGFVGLASVSLHGLPTGSLRLSLSANGPAALSAELPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ59</accession>
    <name>A0A139SQ59_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711163.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02945"/>
    <dbReference type="EnsemblBacteria" id="KXU36729">
        <property type="protein sequence ID" value="KXU36729"/>
        <property type="gene ID" value="AXK12_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="68" mass="7757" checksum="7790EE6C53D56338" modified="2016-05-11" version="1">MSTSEETQSSQQQSLTPEKFPFTAPELMSRYVTDTGKILPRKYTHLSAKQQRAVTRTIKQSRNTLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ73</accession>
    <name>A0A139SQ73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711190.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02850"/>
    <dbReference type="EnsemblBacteria" id="KXU36755">
        <property type="protein sequence ID" value="KXU36755"/>
        <property type="gene ID" value="AXK12_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="369" mass="40375" checksum="F7A3A552070DA60B" modified="2016-05-11" version="1">MKPYRVALIGTGEIATAHVNAVNALKDRLELVAVCDIDTSRAEAFRARYGLPAAYGDHATLLREARPDFVLVCTPPGFHAPASIAAMEAGAWVMCEKPLCASLAELDKIQETEARTGCYTACMFQMRSGSAGNHARKLIQDGTLGRPLVALANTLWFRDRAYYAVPWRGKWETEVGGTTMAHGIHTVDFLLHLLGDWEEVRAIAATQFHAIEVDDLLMAHVRFANGARASIMNSAVSPRQETKIRIDCEHATLEADYLYSYTRENWRLTPSALVASDTAHAAKLHSAWDSLGEDIGSTHTAQIATLIKNRDEGTRPNTSGDEARRSIDFLTALYKSAFTGQAITRGSIRPGDPFYTALNGGQGAVRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA1</accession>
    <name>A0A139SQA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711158.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02915"/>
    <dbReference type="EnsemblBacteria" id="KXU36723">
        <property type="protein sequence ID" value="KXU36723"/>
        <property type="gene ID" value="AXK12_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="284" mass="30038" checksum="AE4F23E260E83C26" modified="2016-05-11" version="1">MKTLRAPLIPGLVSVTFRQLAFAEIIGLVCQAGLRTIEWGGDVHVPHGDLARAREVAVQTRDAGLSVAAYGSYYRAAHSAGLPAGSRLDFARVLETAVALGAPVIRVWAGVESSAEASVDTRRRVAADLMRIAELAAQAGLRVATEFHGGTLTDTNESARSLLFEEAVHPNLYSYWQAPTGMSDEDCLTGLGWLGPKLSHLHVFNWVLGASGQAEALPLEEGEGPTRWRRFLASAAAIFAKSQAGAAAPVPSVPAGMLEFVPGGSPESFLREARTLTALLGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQC7</accession>
    <name>A0A139SQC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711172.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03005"/>
    <dbReference type="EnsemblBacteria" id="KXU36737">
        <property type="protein sequence ID" value="KXU36737"/>
        <property type="gene ID" value="AXK12_03005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="352" mass="38274" checksum="90E8E48C1769B8E0" modified="2016-05-11" version="1">MLNIAVIGCGVIAQQHLRGIAKLKTARAVAVCDVRPEVAQKTAQDHAVPRWSTDASELFADPEIHAVILALPTNLRTPLALEAFKHGKHVLVEKPVAMNLAEARTLVEAQGDRVGACCSSRFRSFASAKAAADYIRGGGLGTIRTITCRAVFKPADDAPTSPPPPWRLRRDLNGGGIFVNWGCYDLDYLLGMLDFQLTPQFALAKAWPVPTAFKAYAAEGSDAETHITALVTFAEGCVLTYERAEFSSLPPTTLWQICGDKGALDLKMLEPTQSNIVLTEPRQGGGIQTRVLWEGEPGTRGHEHDEVVRDFVEAIVDKRKPNTTLKEALLFARIADKLYESIDTGSPVSFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQE8</accession>
    <name>A0A139SQE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02995"/>
    <dbReference type="EnsemblBacteria" id="KXU36757">
        <property type="protein sequence ID" value="KXU36757"/>
        <property type="gene ID" value="AXK12_02995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299403" evidence="1">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="186" mass="19982" checksum="ACD1933C828E8D97" modified="2016-05-11" version="1">MALSLLAVLLPATCAQALPPEAQPGDLIFRRGTSLDSAVVLSVDGGEFSHVGMLLGAPGAWQVIHAVPSEVPGRDDGVVIDELAFFLDPARSQTHAVYHVQASPEQRAQAIEQALAARGLTFRLADPAGTYCTLLIWRAWLDAGLDLEVSFTPLTLPLMQGDYLLPGPLARSRHLRRGDPEQAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQN1</accession>
    <name>A0A139SQN1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">AXK12_02735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02735"/>
    <dbReference type="EnsemblBacteria" id="KXU36886">
        <property type="protein sequence ID" value="KXU36886"/>
        <property type="gene ID" value="AXK12_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="222"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="232"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="49714" checksum="12EBF550BCADD28C" modified="2016-05-11" version="1">MFVPMLASKGDTIVALATPVGTSAIALLRVSGPLAEPIARQLLETVPPTSRTATRADYRDCSGALLDDVLLTLFRAPASYTGEDVLELSCHGNPFIAQKILEDLVARGCRHAAPGEFTQRAFLSGNMDLAQAEAVMDLIHARGERALAAANQQLRGALGRHMQALIDGLLAALARVEAYIDFPEEDLPPEDQDWLSEQIAKLQVSVSKLIQTNHYGNILRAGLRVALLGEPNVGKSSLLNALLGRDRALVSPTPGTTRDYLEEPLLLGGYAFRLIDTAGLNENPEAIEQQGIEKTLSLVDEADLLLLVIDASQPQPPTLPDSVVSALTPDRALLVANKTDLVATRSTTPLQSPSVLSPQLPRIATSALTETGLDALRAALVSHAESFHVEHGAELIAINARHADSLSRAKDGLVRALTQLRSQAPIELIASELRDTLDAFGEIAGRVDNERMLDQLFASFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR2</accession>
    <name>A0A139SQR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711128.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02705"/>
    <dbReference type="EnsemblBacteria" id="KXU36888">
        <property type="protein sequence ID" value="KXU36888"/>
        <property type="gene ID" value="AXK12_02705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="111" mass="12411" checksum="67E2BA5F6E45AB1D" modified="2016-05-11" version="1">MKIKAYLKPTCGWSNGVRAIMRKYGLEFEDVDIINNRANYVEMVQRSGQPLSPCVEIDGVMLADVSGEEVENYLLSNHLVSRSEAPVDTPLNAGCSDEEHAKMATQTLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQR8</accession>
    <name>A0A139SQR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711120.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02715"/>
    <dbReference type="EnsemblBacteria" id="KXU36882">
        <property type="protein sequence ID" value="KXU36882"/>
        <property type="gene ID" value="AXK12_02715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="347" mass="39207" checksum="736D26A10AF4AAAB" modified="2016-05-11" version="1">MTDKPASLTTAPQGYADWLADLKGRIHTAQQRAALAVNRELVGLYWQIGRDILARQVEQGWGTKVIERLAHDLRAAFPDMKGFSPRNLKYMRAFADAWPDAEIVQQAAAQLPWGHNLVLLDRLKTPTERLAYARAAIEHGWSRNVLNIHIETRLLERTGKAVTNFDQRLPAPQSDLAIESLKDPYRFDFLGLGEEAQEREIENALVQHVTDFLLELGAGFAFVGRQVLLDVGGEEFFIDLLFYHLKLRCYVVIELKAGKFKPEHLGQLGFYLTAVDRQVKHTQDNPSIGLLLCKSKNKVVAEYALGDKSQPMGIAEYKLVESLPQELQTSLPTIEQIERELGEPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQV2</accession>
    <name>A0A139SQV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">AXK12_02645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711107.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02645"/>
    <dbReference type="EnsemblBacteria" id="KXU36928">
        <property type="protein sequence ID" value="KXU36928"/>
        <property type="gene ID" value="AXK12_02645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU36928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="344" mass="36815" checksum="A98B26D8F30884D6" modified="2016-05-11" version="1">MATSSFTVGIVGATGAVGQELLRLLLERDFPCERLRLFASARSAGKVITQGGQTFTVEEARAGVFGDIDLAFFAAGGGVTRSLAPDAVAAGCVVIDKSSALRMEPDVPLVIPEINPEGLRQHKGIIANPNCSTAVMLMGLWPLHKAFGLKRAIVATYQSVSGTGAEAVRELEGQVQAHVAGSPIKAQVYPQQIAFNCLPHIDTFGPDGYTGEETKMAQESRKIMGLPELRVSATTVRVPVVRAHSIAVSAEFERPVDLAEARRAVSEFEGAELIDAPENNSYPTPLAFAEKVKCGVGRLRRDTAFDNGLSFWVSGDNLWRGAALNALMNAELMIREGWLKPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQY7</accession>
    <name>A0A139SQY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">AXK12_02415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711067.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02415"/>
    <dbReference type="EnsemblBacteria" id="KXU37019">
        <property type="protein sequence ID" value="KXU37019"/>
        <property type="gene ID" value="AXK12_02415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="369" mass="40249" checksum="755A2EF4EEDDD70B" modified="2016-05-11" version="1">MTSLPSPDSSAAEAALSSRQRFLAACACQPLTRPPLWVMRQAGRYLPEYRALKEKHSFLQMVRTPELALEVTLQPLRRFPGLDAAILFSDILVIPEALGQPYAFRDTGGIAMAHRLDSRAAVEALAPPDVISEKLGYVFDALRLIRRELDSPPSPGETGVRAKALLGFGGSPWTLASYMVEGGSSDDFSSIKSLFYTDRPLFDSLLAKLSAALIRYFTLQIEAGADAIQIFDSWGGIIAGLDYEAASLRWIREIIAALPENFPVILYLKGGAPQLDAQAKSGARVLSVDWTTDLAKVRRSLPPSVAVQGNLDPVLMQTSPEIVARETARLLDSMRGLPGHIFNLGHGITPQAKLECMQALVDTVTRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR55</accession>
    <name>A0A139SR55_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02400"/>
    <dbReference type="EnsemblBacteria" id="KXU37017">
        <property type="protein sequence ID" value="KXU37017"/>
        <property type="gene ID" value="AXK12_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="336" mass="37239" checksum="9C336B3F85D380EC" modified="2016-05-11" version="1">MSPEAKKLALTLERRVPTSMRHKKGSARVATGGFTLIELLVAVSISAVLAGLLVVVTRNTLDLWEKAQDRSFANVQASVALNLLTQDLQSTLTRVSESTLALNILPASALGAHNWRTSEPLLKPDWVNILTAAPDPLRRRYIEHSRFGRGGVWLRFLGFNLNPDGSLPQAISYQIVRRPMAGGINATNPPPIRYILFRHYTTPDDTFATGYDISSYDALLARPAVDQALCDNVVDFGVWCYRRESDGSLTVLYPQSPDSRDFLAQPGSSGATFPDVVEVMLRVMTERGAAQLEQMELGLVTRPPGYASDEEWWWAQVLAESRVYSTRILLNRPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR65</accession>
    <name>A0A139SR65_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711074.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02460"/>
    <dbReference type="EnsemblBacteria" id="KXU37027">
        <property type="protein sequence ID" value="KXU37027"/>
        <property type="gene ID" value="AXK12_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="359"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="447" mass="48777" checksum="28875DF4A9CCFF4C" modified="2016-05-11" version="1">MSSKRTIPARRFIKPSFHSLIEKKRDGQEFTQEEIRYIIDSTLDGEMPKHQLSALLMAIYFANMSAQETATLTEEMMLSGEVIDLSHIAKPKIDKYTTGGVGDKAALVLVPLAMAAGVVVPMMCGVEHDYIMSPIDKLRAVPGFEGKLSIEAFTKQLAKVGGAIVKQDEHLAPADAQFYALRKETGTIPSLPLITGSVLSKKLAEGAEGLVIDIKWGNGSFVKDLEQAKQLARSMTRVGRALKRRCVALVTDMNQPLGDSVGTSLEIKEAIQLLKGEGPEDLKELILKLGMEVVRLAGVAGSTLSAKQTVQRHLTDGTALEKLKDLIKAQGGDTSYIDHPEKFPVARHVRKLPAPKRGYVHTINAAYIMQGVTILNGSSDKKGKIDHAVGVSEVKKVGTQVKQGEPLMMIHYNDEAKLEQALECFKTAYRLAPKRPNPPPLVVERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR67</accession>
    <name>A0A139SR67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">AXK12_02495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711080.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02495"/>
    <dbReference type="EnsemblBacteria" id="KXU37033">
        <property type="protein sequence ID" value="KXU37033"/>
        <property type="gene ID" value="AXK12_02495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="39092" checksum="AED6EC1DE83F9BBF" modified="2016-05-11" version="1">MILALESSCDETAVALFSPERGIVAEWVHTQMALHERHGGVVPDLATREHLRHFPALIEAARERPEFAQVDTVAVTQGPGLAACLAVGLASAKALGLALRVPVWGVNHLRAHAFSPFIALHARCLGEFDEEFGKLLPHLGLVVSGGNTLLVEIDEERRLRVLSTTRDDAAGEALDKGAKLLGLGYPGGPLVEKLAREGDAAAYDFPRGLGGRRDNLEFSFSGLKTSLRYQLEKMSLGEVERRLADLCASYQQAVIDALLRKLESALAAKPSGASEQLAHGARAESLRRSAYRSIGLSGGVANNRLLRESVSSLAAKRGLPVMIAESRHSGDNAGMIGFAAWADTQGVDRTSRLALEVRPSMRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR99</accession>
    <name>A0A139SR99_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase Obg</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">obg</name>
        <name evidence="8" type="ORF">AXK12_02360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711081.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02360"/>
    <dbReference type="EnsemblBacteria" id="KXU37034">
        <property type="protein sequence ID" value="KXU37034"/>
        <property type="gene ID" value="AXK12_02360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="159"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="36149" checksum="CE13B17C208302D0" modified="2016-05-11" version="1">MFIDECVVKVSAGEGGRGCVSFRREKFEPWGGPNGGDGGRGGDVVLLGDDDTNNLVDYKYKPHWRAESGEHGMGSDRHGRDGKPCVLRLPLGTVVIDEETGKAVAEVLEDGQRITLCQGGNGGWGNTHFKTSVNRAPKHANPGQPGAAGTYRLVLKSIADVGLVGFPNAGKSSLTNAITAARPRTGAYPFTTLHPQIGVIEYPDEQAGDRRLFLADVPGLIAGASENRGLGHRFLRHIERCALLLFLIDMAGTDARDPRDDYAQLLRELELYDPSLLEKPRLVVANKMDLAEAKQWLPKFKRRHKAPLLEISCLEGRGLEELKAELLKQVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRB2</accession>
    <name>A0A139SRB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711052.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02330"/>
    <dbReference type="EnsemblBacteria" id="KXU37098">
        <property type="protein sequence ID" value="KXU37098"/>
        <property type="gene ID" value="AXK12_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="253" mass="28998" checksum="22DAE4B4BDF82520" modified="2016-05-11" version="1">MAKAISSLEWCVVRLGDDHNWWVAETSDPVRWDVDGLSIVDPRQVDHLIELVDPLRDYGFSQDVFEAAFIPFRIEKDLGDGRVRLKRVKDSLFDSAEKLFALADILDEENGPYADLLDHLTRCRVKMLNDTIDFEVKLSVDEVEDEIREAQNADFIEGVAVHTFNELIAILDYIPAGYEGDEDAAEKPLATDDEDLPEIDEEEEQKLKDDASLKWDEEDADEEDDLDDEEDEEDDDDEEEGDDYEGRPAKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRC1</accession>
    <name>A0A139SRC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37087">
        <property type="protein sequence ID" value="KXU37087"/>
        <property type="gene ID" value="AXK12_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299420" evidence="1">
        <location>
            <begin position="24"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="703" mass="75790" checksum="9400F97DFFD67244" modified="2016-05-11" version="1">MFRYSQWLPVLSFVLTLSGKSFAAEQAPQEAPAQPASSAPLAPSVVATHETRDTHFTALHGDLSFRVSPAGSATPDEPIRWNQLVYRDGQLVFGARESLGTILWETAIDLGNYAMRSLSLAAGRDANEVATLVMKRELIGHRGLQLVGDGRMDIATANPHFTGPLLIEGAELRLSEQGTLKKHPAVQVSAGGSFVIDNRDVQHVVNKRFNGGDLALSSGNFRFLTRNNAAALERIGTLTVGQGASKFEVSGGGPGKLGTTISIGKLSFAAPAAHLNFVASNGSDFSQNTTVKFLQKPELLHGVIPRTTVNGCDWATVDSHNQLRAYSGYETGSDKSWGPSVNAAPAGNLLVSADRSLASLKFEGEGLGGDDEDRNPLGRIVDLNNHTLTVTGAGIIATGDEFRHQLRGGTLTTTRDNYEIHVSGTGGLAIENTIITDGPNGPTGLIKTGDGELVFSSPKPPAPKVNDNSFTGDVYVNQGTLTLFRKRGSVHNIPGLNIYVGAGQGNARISVRGASEQINEKATVTLRGGPKGEAIFRLDRAQPPRGPRQTLQKLVIEGSGVIEFYSSYIGSGGETTDNTKSILYLGELEINGELIVRGWDKYNTHILIDSKEAPTEELISKIKFEGEYLNKIFVEKFYAKEKKKDYWEIKAEFEYIPPTYPPPPETPEPATTGALLATGALAFSMWHRHRRARKIRHEARCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS41</accession>
    <name>A0A139SS41_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710965.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01890"/>
    <dbReference type="EnsemblBacteria" id="KXU37378">
        <property type="protein sequence ID" value="KXU37378"/>
        <property type="gene ID" value="AXK12_01890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="245"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="490" mass="52893" checksum="959F49941B9AEFD1" modified="2016-05-11" version="1">MQQPATAPMSLRLKLTGIKKAFGATRALDGVSLEIGEAEVHALIGENGAGKSTLMKVLSGVIQPDAGTMQLEGHAYAPADTLDARRHGVAMIYQELSLAPHLNVWENIGLGALPNRGGWIDRPAARQRAREALARLAHEHLDLERAVADFSIAEQQIIEIARALLSNPRVLIMDEPTSSLTQADTRKLFEVIAQLRASGVSIIYISHFLEEVREVAQRYTVLKDGRTVGSGVMADTPQSEILRMMVDRDVSELYPQRSAKLGPPRFTLEGAGGPLTVHEGEILGIAGLIGAGRTELLRANFGLDPSAHVKGRPNPRKRWRERVGFLSENRKEEGLMLVLSLAENIGLTKYPELARAGGYLAPRRLLGMATPWLGTLGIKARASEQAVGDLSGGNQQKVALARLMEHPAEVLLLDEPTRGIDVGSKAQLYQVIARLAEQGKAIVVVSSYLPELFGLCDRIAVMRGGAVVACKPTPEWTEPELMSAAVGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSF1</accession>
    <name>A0A139SSF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01835"/>
    <dbReference type="EnsemblBacteria" id="KXU37410">
        <property type="protein sequence ID" value="KXU37410"/>
        <property type="gene ID" value="AXK12_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="297" mass="32854" checksum="89664835573A77B9" modified="2016-05-11" version="1">MLDLSVEDITVCYPNGHEALRDTSFRLEGGTICALVGVNGSGKSTLFRAIMGFVRPASGRVRIAGRSVQSALKANLIAYVPQSEEVDWSFPVSVWDVVLMGRYGYMNFLRIPRARDREIAEESLRRVGMLEFRERQIGELSGGQKKRVFLARALAQRSRVILLDEPFTGVDVQTETAIIGLLRELCAAGHLILVSTHNLGAVPEFCDSVVLVNRTVLAAGPTAEVFTQDNLVRAFGGVLRHFKFDESTVQKHDEKAVTLLTDDERPLVFGKGGHLEYSHRAGKENVIAERAEEEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSF3</accession>
    <name>A0A139SSF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ORF">AXK12_01975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710977.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01975"/>
    <dbReference type="EnsemblBacteria" id="KXU37391">
        <property type="protein sequence ID" value="KXU37391"/>
        <property type="gene ID" value="AXK12_01975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="349" mass="36824" checksum="C940C86AC34E6396" modified="2016-05-11" version="1">MPILHELTTQLLGGRELSSEQVEAAAAALEAPEVSGSMKADFLRALADKGESAEEIAAFAQAFRRRAIDPNMSDWSERAIDIVGTGGDHSGGFNVSSLVVLTLAAAGVPAMKHGNRGITSKCGSADILAALGVDLFAPPAVLRKAMEQLGFVFFFAPNFHPSFKHIAPVRKVLATQGKRTIFNILGPLINPGRPAHVLLGSFSPDWVPRLAAALAALEPQAGLVVHGEIAAGKGIDEITTATRNRVLGVGRAAQVDGTWEAEHYGLQAASFSELQGGDLPQNLALVDALLAGKGPRGLEDTIVLNTAIALWLVGKVDKIEDGLAPARELLVGGAVRRKIEDTRQFYRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SST8</accession>
    <name>A0A139SST8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_01680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710927.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01680"/>
    <dbReference type="EnsemblBacteria" id="KXU37520">
        <property type="protein sequence ID" value="KXU37520"/>
        <property type="gene ID" value="AXK12_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="858" mass="95971" checksum="DEA68F149AD18861" modified="2016-05-11" version="1">MPKPPATAKQPIASTKTKSSRGAKPAPAAAHSAEVGASGVPTSGVPTVEGFKQAILRHLVSTLARVPQAATPHDWWVATSLAVRDSLHERLIATQDRYIKDNVRRLYYLSMEYLVGRLFESNLYATGLADVARTALAELGVDYTQTLDAELDMGLGNGGLGRLAACFFDSLATLDYPAIGYGMYYEFGLFRQEFVDAHQVEHPDRWRVFGSPWEVLHSDYAQEIPLYGRVENHFDDRGHSTPRWVDTKTILGLPHDIAVAGYGTRTVNLLRLWSSHAPDDFDLAAFNEGSYAEASRKKQAGESISKVLYPNDKTENGKALRLVQQYFFVACSLRDILRRHFRDPRNSWANFADKAAIQLNDTHPAIAVVELMRLMLDEHGLGWDEAWALTTLTLSYTNHTLLPEALETWGVPLFERLLPRHLQLIYEINRRLMQHCVAHWPQDLEKQRTCSIFEENGAKSVRMANLAVVGSHTVNGVAALHTELLKRELFPEFAELYPGKFQNKTNGITPRRWLLQCNPRLAAFITRTLGHGDWVRDLDRLRELEAHAAQPDVQREFLAIKRANKAELADIIARDCSGLCVSPDALFDVQIKRLHEYKRQHLNLLHILALYRRLLQNPQLDLVPRVFIFAAKAAPGYDLAKNIIRAINLVAARINADERIGGKLKVAFLPNYRVSLAEKIIPAADLSEQISTAGKEASGTGNMKLALNGALTIGTLDGANVEIEEAVGAENCFIFGMTVDEVAALRARGYYPRSVYDADEELRALVDWIGSDFFTPGEHAAFAPLHHSLLGGGDPFMVLPDFRAYSDAQQKVEACYRDSTQWAHKALLNVARVGRFSSDRTIREYARDIWRLPAVPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSV3</accession>
    <name>A0A139SSV3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710889.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01485"/>
    <dbReference type="EnsemblBacteria" id="KXU37637">
        <property type="protein sequence ID" value="KXU37637"/>
        <property type="gene ID" value="AXK12_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="313" mass="33587" checksum="FB89099CB7EE5F9F" modified="2016-05-11" version="1">MAFNLKKVLRALLFSSSQPLTIKDIQTTFARFHDSEEAREAAAQDAVSATGTLDGAARAASDEADADGDALSEEERELYAEVPSLVTATQIRDAFAEIAAEFAAADEGLLLVEGSSGYQLVTHPRFARWVRLLRGEPAPARLSRTALETLAIVAYRQPVTRSEIETIRGVSADAGLNKLIERELVYVVGRAEVPGRPIQYGTTEQFLDFVGLRSLDELPASDVLSNRQINAWLQSAAEAVAAPQPLADEAMGLPLEEGEGETPNLEEVSLETGLAPSSEAATSRDAENFIIETNELAQESAAAVETAEKEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSW6</accession>
    <name>A0A139SSW6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710916.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01570"/>
    <dbReference type="EnsemblBacteria" id="KXU37663">
        <property type="protein sequence ID" value="KXU37663"/>
        <property type="gene ID" value="AXK12_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="25586" checksum="3C831848435F3461" modified="2016-05-11" version="1">MEPASINSATSAFIAGLITSLHCAGMCGPLACTLMPVKGDRADAQLVSSIYHGTRLFSYCVLGAVAGGLGKLPLQWLQNDALFRWLPWVSVLFFIALGLRLDRYLPRPLFLSRLLIRLNPHLRSPSKLKSAAALGLATPLLPCGPLYFLLALALFSGSALRGIEFMLAFGLGTVPLLWLAQAQFQWLRHRLSPLWFARVRITLALSSALIISWRLRSTLGLEGPEVNSLICFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSX8</accession>
    <name>A0A139SSX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="6">DXP synthase</shortName>
            <shortName evidence="6">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dxs</name>
        <name evidence="9" type="ORF">AXK12_01620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="6">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01620"/>
    <dbReference type="EnsemblBacteria" id="KXU37666">
        <property type="protein sequence ID" value="KXU37666"/>
        <property type="gene ID" value="AXK12_01620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="8">
        <location>
            <begin position="315"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="6">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="628" mass="67888" checksum="CB5EC49994076850" modified="2016-05-11" version="1">MREPADLKALAPVQLPALAQEIRDEIIAVTSASGGHVGPNLGVVELTIALHRVFETPRDQFVFDVSHQGYIHKLLTGRGGSFFQKLRQTDGASGFLSRDESPHDAFGAGHAGTALSAALGMATARDLLGTDEHVVALCGDAAFTCGITMEALNNVVTSTKRLIVILNDNEWSIARNVGAIAKYLNRLSTSRTYNRAYHDLEKFFTSLPGGPDMHRLFTKWKRETKDFFVESSLFEKLGLRYLGPIDGHDLDELIKNLEFAKNSDTPVLLHVLTKKGKGLQVALDHPEKFHGSSPYDPKTGENPAQSSGSQNPARQNLQDVFGHALVRFARGNPRIVGITGAMPSGTGLTHLQSALPAQFFDVGIAEEHAVLFAAGLATKGLRPVVAIYSTFLQRAYDQIIHDICLQKLPVVFCMDRAGLSANDGPTHHGLFDIAYLRCVPGATIMQPKDEDELVDMLHTALQHDGPSFIRYPRGTGPETTLKQNPAALPIGQAELLREGSDLALWALGPMLEDALALAAKLESENGLSVAVVNARFAKPLDRDLLLAQAATIPLIVTLEDHVVNGGFGTAVLETLQDAGTKTTVERIGWPDQFVGHGSSVAQLRAAHGLSPEAIYSRVLTRFASDKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST92</accession>
    <name>A0A139ST92_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_01145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710825.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01145"/>
    <dbReference type="EnsemblBacteria" id="KXU37799">
        <property type="protein sequence ID" value="KXU37799"/>
        <property type="gene ID" value="AXK12_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="298" mass="31480" checksum="BFF2322272A18214" modified="2016-05-11" version="1">MILATRKSPLALAQAELVASRLREKLGASVELLPMTTTGDRQAQWSLEKQGGKGLFTTELEQAVIDGEADLAVHSTKDLPGHTSPQLIIAGYLPRADPRDVLVFRSEAKLSCGQGPARPRQANGPLALATSSPRRRGQLALLFPDATFCEIRGNVETRLSKLAENQAGGAEGTVLAAAGLARLGIAIWPGLEFRPLAFTEMVPAVGQGAIAVQTRIEDAAHYAPILDPGTACAVRVERAFQAALGGGCHTAFAAHAAGDTLHLFHEKTGLRRFPLSEAEVHAPADTAKRILNTLGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA2</accession>
    <name>A0A139STA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710829.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01170"/>
    <dbReference type="EnsemblBacteria" id="KXU37803">
        <property type="protein sequence ID" value="KXU37803"/>
        <property type="gene ID" value="AXK12_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="150" mass="15836" checksum="68EDB32445A8B79C" modified="2016-05-11" version="1">MSSKLYDQLRADIITAMKARDSVTTTALRTADAAIKRAELDGNLAIDDALVLATLRKAVKNLSDAREDFLKAGRADLVAANDAEIALLSKYLPQSLSLEKLEALVVDAIAATGATAKRDMGRVVAALKQHADAGSIDFGTASKLIQARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA3</accession>
    <name>A0A139STA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37828">
        <property type="protein sequence ID" value="KXU37828"/>
        <property type="gene ID" value="AXK12_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="420" mass="46199" checksum="8057F1E92149B1B8" modified="2016-05-11" version="1">MSGAGALRVAEHPLRILRVINTLRREDGGPSESVLRSSAALREMGHQVEVVTADPLGTQPPVGAEFPFRPLDGFGRSTLGRWLEENRLRFDAVIVQGLWQAAHTVRCALRGCGLPYLVFPHGMLDPTFARLYPLKHIKKQLYWWWREGRALREAAAVCFTSEEERERARGTFRPYSVKERVVAYGTLRPPRSAERQEAMRAAFLKKYPVLRGRDFLLFLGRLHHKKGLHELIEGFAKFREGQGAGASTSPRALVIAGPCGEPKLLRALMRHAERLGLAQLNLREAGAGAPEAGPSGESAPLIWLPMLGDDLKWGALLASEAFVLASHQENFGIAVAEALACGRPVLISDKVNIWREIAEARAGLVAPDTVAGALDLLTRWAALSPEARAAMGESAIKCFEQNFEISRAAESLAQTIRDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STK5</accession>
    <name>A0A139STK5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_01300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01300"/>
    <dbReference type="EnsemblBacteria" id="KXU37844">
        <property type="protein sequence ID" value="KXU37844"/>
        <property type="gene ID" value="AXK12_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="10"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="345"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="465" mass="48095" checksum="DB94E7350D161613" modified="2016-05-11" version="1">MSPKRTCMDYDLIVIGGGPGGYVCAFRAAQLGLKKIALIDKRPTLGGTCLNVGCIPSKALLASSEHVAFAQKHAAEHGLTFSGLTVDLPAMLKKKESIVAKMTGGLAALAKARKVEVVTGAAQFLDAHTLAVGERKLSARNIVIATGSAPVELPFLKFDGQAIISSTEALALTEVPKKLVVVGGGAIGLELGSVWARLGAEVTIVEFLPQIGGPAADADVVRGYTRSLQAQGLKIEVGAKVTGFKDGQLLAERDGKPLAFAADKVLVSVGRRPFTDGLALDKAGIALAANGRIGVDAQLRTSAPHIRAIGDVVDGPMLAHKAEEDGAAVAEWIAGKAGHINWDLMPAIIYTDPELATVGLGEDAAKKAGRKVKVGKFNFAANARAHANDGAEGFVKIIADAETDTILGAQILGKNAGELISEVVTHMEYSGSAEDLARTIHAHPTMSEAVKEAAAAVSKTAIHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STL8</accession>
    <name>A0A139STL8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_01275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710848.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01275"/>
    <dbReference type="EnsemblBacteria" id="KXU37822">
        <property type="protein sequence ID" value="KXU37822"/>
        <property type="gene ID" value="AXK12_01275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="300" mass="32293" checksum="D7174352074F8D69" modified="2016-05-11" version="1">MISDSTISRLFSEKSRPLRSLEFFPPKEELDVLALKKTASELVKIAADFASVTYGAGGGTRQRTAEVSQLLRGELGCPIMPHLTCVGHSREELHALADEIHASGFRNIMTLRGDLPKSAVQSGTGQKPLEDDAPRYASDLVALLKARHSDFCLGVAAYPEKHPQAASLESDIAHLKAKIDAGADFAVTQLFFDNAVYFRFVEKCRAAGISVPIVPGIMPALSLAQVRRFTAMCEVVLPEKLAAQLAAAGEDNPDEVAHIGTQWTIAQVRELLASGAPGYHLYTLNRARSAVELCAALAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STM5</accession>
    <name>A0A139STM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_00960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710789.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00960"/>
    <dbReference type="EnsemblBacteria" id="KXU37958">
        <property type="protein sequence ID" value="KXU37958"/>
        <property type="gene ID" value="AXK12_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="130"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="4">
        <location>
            <begin position="405"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="632" mass="67539" checksum="C19A423F34D5858C" modified="2016-05-11" version="1">MKSFLRSMLAAFVALVLFFGGGFALLMLAVAMFSFVGKSAGPRVPTVPSGAFLVVNLDTHFRDAPAGPPDFTMALLGGGHLPPTVPLRRALDAIRTAADDERIKGVVIFGGDSATGIAERRELRAALADFKESGKPIRAYLSLASRSQYYLASVADKIALDPFGFVAIPGLASQGLFFKNAFEKLGVGVQVTRVGKYKSAVEPFTSDGLSEENREQTQMLLNDVWGSLLGDMAASRGLEVSEIQAAVDAEGVLLAESALKHGLVDELVYRDEFLAAMRAEAGHGSDGAGNRSFKQISLQKYSRALRAGERAGVFVEKAAAEKKKSVAGEAGGARKPRGRVAVLYAEGAIVDGRGGPGQIGGERFAQELRTLREDSRVSAIVLRVNSPGGSASASEAIQRELSLAAQSKPVVVSMGSVAASGGYWISTPAQRIFAEPVTITGSIGVVGVFFNIESLSEKLGLNFETVKTSRFADTGAIDRPLTAAELSIAQRSVDWIYDKFIERVAEGRGLAPDFVHEIAQGRVWSGLRAQRLGLVDELGGLGEAIAYAAEAAGLEQGRYRVSEYPRPTQFGEALAEFFEEFMQEGFGEARALKANAVVRGLWQRAASELRALESYNDPQHVYARLPLILELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP2</accession>
    <name>A0A139STP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly SUF system protein SufT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710790.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00965"/>
    <dbReference type="EnsemblBacteria" id="KXU37959">
        <property type="protein sequence ID" value="KXU37959"/>
        <property type="gene ID" value="AXK12_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="192" mass="20390" checksum="9E2E988264FC83D1" modified="2016-05-11" version="1">MEHLLMRDVRATRIPSGESVMLPMGAELRIMQALGGNLTVRSDEGLFLIASGDADALGGYVPEGGSEPIDEGGSGTSAAAQAAPREFSADAVWAALRGCFDPEIPVNIVDLGLVYDMAIETSESEKGVRYRVEVKMTLTAPGCGMGPVIAEDARARIAALPDVEDVKVHIVWDPVWVPQMISEAGRKKLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP3</accession>
    <name>A0A139STP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710856.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01330"/>
    <dbReference type="EnsemblBacteria" id="KXU37830">
        <property type="protein sequence ID" value="KXU37830"/>
        <property type="gene ID" value="AXK12_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="26888" checksum="C2BDA52D6F6450D9" modified="2016-05-11" version="1">MIKLDAVELGWPDAPALLSGLSLQIAAGEKVALLGPNGCGKSTLLQMLAALVFARSGVYRYCGQAVTRAQLRMRGWERAFRRDVGLVFQHPEAMFFNATVHDEIAWGPRRLGWLDAEERSARWAQELGLTALLEQPPHSLSGGEKQRLALACVLILEPKLLLLDEPSANLDPQSLGWLCDYLLSLETTLILSTHSLGFAAEVAKRVLVIERRAGLLADGPSEAVLGNTELLIRAGLMHRRKHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUC3</accession>
    <name>A0A139SUC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000001">
        <property type="protein sequence ID" value="KXU38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38124">
        <property type="protein sequence ID" value="KXU38124"/>
        <property type="gene ID" value="AXK12_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="138" mass="15700" checksum="69017E4B37084E50" modified="2016-05-11" version="1">MGGLYFSSMGGDIIQSFKQLIIDGLGVISFGVNGKVDSITKIYLDDLWVRSGREVNIFHWREGRDFILVKKTSKNLADTMKKIKFFGYDPSKLHLEDYNDEYWMINGAPEPATYGAGLMLGVLGLVCYRRRQRSSPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHE3</accession>
    <name>A0A139SHE3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_08075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08075"/>
    <dbReference type="EnsemblBacteria" id="KXU33985">
        <property type="protein sequence ID" value="KXU33985"/>
        <property type="gene ID" value="AXK12_08075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="292" mass="31260" checksum="C17E2CA60EA5C29E" modified="2016-05-11" version="1">MHSGSSKIITTVGPLARNPASAQTGPWPLAELYAALVSGIRDYAQQNGFKRILVALSGGIDSALVAALAVEALGAENVMTVSLPSRHSSQHSRDDARDLAANLGVRFETIEIAAPVAAVESALAPLFVGLAPDLTEENIQARMRGLLMMALSNKFGSLLLSTGNKSEALVGYCTLYGDMCGGLAPIVALYKTEVYALSRWINREREIIPQSTLDKPPSAELRPDQKDQDSLPPYDTLDEILRQLFDAGLSPDKVVSESFDKKTVEDVAQKLARSAFKRAQAAPALNLHFSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHM7</accession>
    <name>A0A139SHM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_08250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713360.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08250"/>
    <dbReference type="EnsemblBacteria" id="KXU34046">
        <property type="protein sequence ID" value="KXU34046"/>
        <property type="gene ID" value="AXK12_08250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="42927" checksum="C071FDF83AB9A3D5" modified="2016-05-11" version="1">MAAPNRAAPLGLYVHVPFCASTCDFCAFYQVRPTASDIADYFAACEAEAALVKWSRPVTTVFWGGGTPGLLSPDALRRLGEFTLRCCSETECGSGPTEWTVEMAPASVTEARLAALREIGVTRISMGVQSFQAALLAALGRQHSREQIYRAYERIRAAGFSSVNLDLMFALPGQTAAEWEADIAEALALAPDHLSTYCLTFEEDTALWLKLSQGRVKLDPEHEAQLYEQTWARLAAAGYGQYEVANFARPGHACRHNLNTWAMSEWVGLGPAAASQHGGWRGGNVADLRGWAERVQRGERMTEERKEMTPAALAEDAFIFGLRMNAGVSLEEWRTRAPDAPWAAVEALAERLVADELALWSDDRLCLSTRGRLLADAVGLEMMEAFQDASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHY3</accession>
    <name>A0A139SHY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713164.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07885"/>
    <dbReference type="EnsemblBacteria" id="KXU34185">
        <property type="protein sequence ID" value="KXU34185"/>
        <property type="gene ID" value="AXK12_07885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299203" evidence="2">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="38951" checksum="A3032CDC51ECE297" modified="2016-05-11" version="1">MTTSPLPRALLGFVCSLLLAATSALHAQNDNLDLRFANGIAAIVEEKVITVDDIRREIAPLIPEIQRSARNEADFTRRLEELQDSIIQDLIDRVLIIKEFRKDDKRQIPPGFIDRRIADIQAEQFDNDRSKFLSYLRTRGITMREYRREVEEDIIYGYMRAQQRRSESIISPVRIETFYEENQDRFYQEDSVHLRLIQINRAPGETEPQHYSRASEIVARFRAGESFAELARQHSQDSRRTRGGDWGWQKRSDLKAEFSDPLFELKEGEISAPVMTPEGCFILYAEARKYAGIQPIDEVRPEIERMLLQQMGRQSEDRWLERLRRNGYVKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI92</accession>
    <name>A0A139SI92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712987.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34295">
        <property type="protein sequence ID" value="KXU34295"/>
        <property type="gene ID" value="AXK12_07385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="484" mass="54660" checksum="CB5453E03A3627FC" modified="2016-05-11" version="1">MPHSTPPQTESTPDKKLSQSRPRFLSSLSGKLLSPGIVVILALALASSALVWLLPARQRSGIPFWLTAHRHYEAYQPKLDEWNARHPEKQVAATLFHTRAFERRMLSGFLSETPLADLLESDVSVIPRAFLGPPEQVGFLDLTDRLHAEGIYEQLNAPSFSFFTSRGRIYGLPHDVHPALLCYRADIVEAAGIDVSQIETWDDYFRVMHPLIQDLDGDGRPDRYLLELSEYRTSEIIMLLLQNDGEIFDEYDRPIFANPRNARTLATLTTWITGPNRVTSNTSGLAAHRQRLEGLVVGVIMPDWMLGYWKVENPQIGGKIKLMPLPAWERGGRRTSVRGGTMIGINKRSPHIETCWEVLKYLYTSIEVAEQTYRDSSIISPVKALWAAPFYDEPDPFVSGQPSGRLYIEQAPHVPHRPSSPYNPTAEDYIGSVAMALRSYADQHAVYDIPQLETEALRLLQEAQARLEKLISRNVFLTSPQHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC1</accession>
    <name>A0A139SIC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713043.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07555"/>
    <dbReference type="EnsemblBacteria" id="KXU34322">
        <property type="protein sequence ID" value="KXU34322"/>
        <property type="gene ID" value="AXK12_07555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="51126" checksum="5A5D61B07EDD697C" modified="2016-05-11" version="1">MSGSGNTAELRNQLIALLRAHDTAGLRATLKPWLPVDLAPIIGDLPVELLAQLFRTTSRDLAAATFPYLEHESQRHLLKLMTPEQSAALLNALPPDDRTAFLDDLPLEHAMQLLSLLTPDEREIAKALLAYPEHSVGRMMTLDYVAVRPEWSVSEALDYIRTHGYDRETLNVVYVVDEHGRLIDDVRVRRFLLCTSDQSVRDLMDGNFSALSPYDDRETALEVFRKYDRVALPVVGEGRKLMGIVTVDDMLDVAEEEATEDIQKLGGSAAFDEPYTTTPYVQMLRKRAPWLALLLVGEMFTATAMGYFEEELSRAVVLALFIPLVISAGGNAGSQAATLIIRALALGEFTLREWWRVMYRELFVGASLGVILGTIGFCRVALWELASPGIYGEHTMLIGVTLGVALSGIVLWGSLVGSMFPLLLKRIGLDPATSSAPFVATMVDVTGLVIYFSVAFVVLRGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM9</accession>
    <name>A0A139SIM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712932.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00540"/>
    <dbReference type="EnsemblBacteria" id="KXU34432">
        <property type="protein sequence ID" value="KXU34432"/>
        <property type="gene ID" value="AXK12_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="418" mass="45964" checksum="14294638271066B8" modified="2016-05-11" version="1">MHSRFDFTTPPERRHTDSQKWLKYENRDIIPMWVADMDFRSAPEILDALHARVDQGIFGYARPCPSTTAAIVTAMQTRYGWTISPEWIVWLPGLVCGLNVTAQAFAGTGDEVLTLAPIYPPFISAPKNSGRRTVTVPLKLEEQNDAEAEVTTEGSGSVCDRDDTPNKKGLRAWVIDWPALEAAVTPRTKLFLLCNPHNPIGRVWRRDELAQIADFCLRHKLTLCSDEIHCDLVLEPALRHTPTALLSSEIAARSLTLMAPSKTYNLPGLGTSFAIIPDAALRAQFNRAASGIVPEVNALGYAACEAAYRDAEPWRQALLETLRGNRDRLIDFVKNELSGVEIEAPIEATYLAWLNVRALGLADPVTHFEAHGVGLSDGAFFGAPAGHYVRLNFGCPRSTLDAALRRLKTAVETAPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP6</accession>
    <name>A0A139SIP6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712957.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00590"/>
    <dbReference type="EnsemblBacteria" id="KXU34445">
        <property type="protein sequence ID" value="KXU34445"/>
        <property type="gene ID" value="AXK12_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="23370" checksum="4381E0A4BF3A49CB" modified="2016-05-11" version="1">MNFYVRALGPVQTNAYLLTEPERGEAVLIDAPEAVWAEVAPLLAHDKCRLSELWLTHGHWDHMQGAAEVVRESGAQVLAHSADQPLYEEPERMRSFMFESSKLEPVGVDRWVGQGEAHEALGLRFEVRHVPGHCPGNILFYAKALRAAFVGDALFRGSVGRTDLPGGDFEALAQSIRQQIYTLPAETRIYSGHGPETNVAAERATNPYVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIQ9</accession>
    <name>A0A139SIQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712926.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00525"/>
    <dbReference type="EnsemblBacteria" id="KXU34429">
        <property type="protein sequence ID" value="KXU34429"/>
        <property type="gene ID" value="AXK12_00525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="547" mass="61624" checksum="0FDD24FC2EC18EF7" modified="2016-05-11" version="1">MMKLSKEGDLGLFTHVTTESLGAPFTGQLNDFPQTERVIVWLGGQVARVIGLMPAANAMLILSCIVAAFSFYAAARFWKISRLSSWAFAVVYAFLPHNQRSLDSLGVIATGLLPLQFYCLWYIATVQNVSWGSFRFRLTLAIGLLSGLLNIYWVFFFLNLYVLALLCRILKGRKNSIASLAPIITTCLIVGALLGSYIVYRMSYGENPAALVRSYGDVDRESLKPIELFIPRWGTHLEMFAGFFSRYYDGGKMDIGEEWWGIYIGLLPMAGLLFLFLKGIQRQVNKRAPSLPFLAGCWIIAYSSFGGINAIFSLILNFYDIRGTNRYFVAIATIGLIYFAFVINRLMRNCSFATKLSALGGLALLAMMDQSFHNYFHPRYNIPTRVIKERVMADRDLALRLEDSLEAGAMIYILPVLDFPEPFEGRGAYKINFFIYDPIRPFLYSTKLRYSYGSNKGRQGADWQLDVQELPPKEMAATLESFGFSGILFNRKDYADGGEKFLTELGEAGWPMEFEQGIGNEWVFIRLTPAARPALPTLTPYALASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIS1</accession>
    <name>A0A139SIS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712934.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00545"/>
    <dbReference type="EnsemblBacteria" id="KXU34433">
        <property type="protein sequence ID" value="KXU34433"/>
        <property type="gene ID" value="AXK12_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="42790" checksum="4A98341FC9A419A1" modified="2016-05-11" version="1">MKIVDIETYAVGAGWKNWLFVKVITDEGIYGIGEGTLNGFIRTTEAGVHELKHLAIGQDPRHITALVKRLLDSVSLDGGHIHRTVIAAIEVACWDILGKHLGVPIYQLLGGRARESVLGYANGWYRTERTPEAFLQAAQAVLAKGFKAFKLDPFGTAQSFISKEELELAYEICRTLRDRLPADTRILIDVHARFTGIAALQAAQKFADLDIYWFEEPTGRDRQETVHEMALRSPIPVATGEMYDTVGQFYTLAQGGGVNIFQPEPMSLGGIGASMQVAAIAAGHGSVIAPHQSGGPVATAVCLQLAAAVPNFLIQEHFDAFNEPWTRELVTWHPTVNPDNGHLSFPDAPGLGIDLNIDAIKAHPYDPNAYLNVHTEGWERRLGTRPQGSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIU3</accession>
    <name>A0A139SIU3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712948.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00385"/>
    <dbReference type="EnsemblBacteria" id="KXU34441">
        <property type="protein sequence ID" value="KXU34441"/>
        <property type="gene ID" value="AXK12_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009362">
        <property type="entry name" value="YhcG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041527">
        <property type="entry name" value="YhcG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17761">
        <property type="entry name" value="DUF1016_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06250">
        <property type="entry name" value="YhcG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1016_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="YhcG_C" evidence="1">
        <location>
            <begin position="177"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="351" mass="39943" checksum="B06804B7DF4668A2" modified="2016-05-11" version="1">MSKDQLTVSPVGYADWLAELKQRIHSAQQRATLAVNRELVLLYWQIGQDILARQASQGWGTKVIERLAHDLRAAFPDMKGFSPRNLKYMRAFAEAWPDGEFVQAALAQLPWYHQLALLDKLQSTEERQWYAAQALENGWSRNVLVMQIESGLRQRTGKAVTNFDQRLPAPQSDLARESLKDPYRLDFLGLGKEAQERAIEDALVKHVTQFLMELGAGFAFVGRQVHVEVGDKDFYIDLLFYHLKLRCYVVVELKAGEFQPEYAGKLNFYLSAVDSQLRHPSDNPSLGLLLCKNRDKVVAEYALRDMNKPIGVAEYQLVQALPKELQTDLPRIEDIESELRDAEDAPGEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ30</accession>
    <name>A0A139SJ30_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murD</name>
        <name evidence="11" type="ORF">AXK12_07270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712850.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07270"/>
    <dbReference type="EnsemblBacteria" id="KXU34543">
        <property type="protein sequence ID" value="KXU34543"/>
        <property type="gene ID" value="AXK12_07270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="112"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="443" mass="48203" checksum="66A79161F205177A" modified="2016-05-11" version="1">MQFPIPSLLKSALAKPVAIFGMGVSGFAVQQLLTAVGAESLLYDEASDTVFGEEDCAEHALVVFSPGFAVDHPWLQLARAHGLLCLGELDFSALFWREQLQAIHRRGELIAVTGTNGKTTLTEFLTHALRVGGERAYAVGNIGKPLAQLVLENTARYGAGRGSARDSRQIVVCEVSSFQAESLQYFYSDALLWTNFSEDHLDRHVSMENYFSAKARLLASAPADCTFSGACVARAARDFGYAFPPYAAMRCDGPFADEALDGTDFDTLPHRDNFRLGFAWWRHTRRPPETLYKAAQTFTLGRHRLTLLVELDGVTYWDDSKATNFNAVEGALARFAETRTPVNLILGGRSKGGDLRGFIERIAPRVAHAFLIGETASELASSCAAAGLAYTRCNSLEAAVKAAHAKAQPGEAILLSPGFASFDNFRDYRARGEAFEAAVRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ36</accession>
    <name>A0A139SJ36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">AXK12_07200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712825.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07200"/>
    <dbReference type="EnsemblBacteria" id="KXU34531">
        <property type="protein sequence ID" value="KXU34531"/>
        <property type="gene ID" value="AXK12_07200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="103" mass="10967" checksum="CEDD9012FE986168" modified="2016-05-11" version="1">MALKIRLTRVGSIHNPHYRVVVAEARSRRDGAAVEYLGTYAPRNKGEQLKLNLPRVDYWISKGAKPTDTMGAMIKRARKAAPAAAAAAEAQSALAAEPVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ46</accession>
    <name>A0A139SJ46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6">6.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_07260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712846.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07260"/>
    <dbReference type="EnsemblBacteria" id="KXU34541">
        <property type="protein sequence ID" value="KXU34541"/>
        <property type="gene ID" value="AXK12_07260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="121"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="311"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="469" mass="49340" checksum="CEBEDA7F3F7CCDE5" modified="2016-05-11" version="1">MTSFDAAELAQWAQASWTRFPGGGLGGFGIDTRQLRPGQIFVALKTENRDGHDYLAAAAQAGAAAALVARADASIDLPQLVVEGGDTRGGSRGGDTLRAFQQIAQKHREKFQAAGGRVIGITGSVGKTSTKNLLAALLGAQSGQGDRVLATEGNLNNHLGVPLTLTRIDAARHRFAVIEAGIGGPGEMAPLAQMIGPDVAIVTAVAAAHLAELGDIDGVAREKAILAAHVRAEGVAIFPAPLGDFEAFRSSKTQRIDEGTFGGLTREFTLPTLSAGMAQNARLAIRAALYLGVAPAQIQARLKAWSPAPLRGQTLSEPDGRFLYLDCYNANPASMADALDAFYAQAPEALPRVFVLGGMEELGERSAMFHRALGRSLRLRAQDRAYALGDEAEALRTGALEGGQVTPEQIRVVETLDSLRAKIADFRGALFLKGSRRYRLEDLVAPEGSTAGSPNDAATTNNLSEATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJE7</accession>
    <name>A0A139SJE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">AXK12_07070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712776.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07070"/>
    <dbReference type="EnsemblBacteria" id="KXU34695">
        <property type="protein sequence ID" value="KXU34695"/>
        <property type="gene ID" value="AXK12_07070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="22495" checksum="1801165031EEBD87" modified="2016-05-11" version="1">MSQYTLNTQARTQKGRSASRRLRKANRVPAILYGKHSAPEGLSVETPEFTKLLKAVGGRAVLVELSIEGRAEKALSFIQEVQRDPITDRFLHIDFQAVKADEKIELEVPVRTKGEAVGVKTQGGVLEVIAHQLRIRCLPADLPSSVEIDVSALKVGEVLKVGDLAELSGVEFLDAKGHPVLSCVEPVGEAGGGTANPAADAKADAKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJM7</accession>
    <name>A0A139SJM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">AXK12_06940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712752.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06940"/>
    <dbReference type="EnsemblBacteria" id="KXU34759">
        <property type="protein sequence ID" value="KXU34759"/>
        <property type="gene ID" value="AXK12_06940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="354"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="427" mass="45333" checksum="EB58C403E218D67D" modified="2016-05-11" version="1">MLNATPLKTLDPEIYSAIAAELARQQSHIELIASENFTYPAVMEAQGSALTNKYAEGYPGRRWYGGCEYVDKIEQLAIDRAKALFGAEYANVQPHSGSQANFAVYTAVLQPGDKILGMNLSHGGHLTHGNPANFSGKLYQFSQYGVSEADGLINYDELAALAQSEKPKMITVGASAYSRIIDFEKMGEIARSVGAYLFADIAHIAGLVASGHHPSPVPHADFVTTTTHKTLRGPRGGLILSKAEHAKALDSAVFPGGQGGPLEHVIAAKAVCFGECLKPEFKVYGAQIIKNAKALAAALVARGYNIISGGTDNHLMLVDLRAKFPELTGKAAQAALDTANITCNKNTVPFETRSPFQASGIRLGTPAVTTRGMVEADMAEIAEQIDRILSAAASGNNDSLASTAAEVKTKVLALTARYPLPYRTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJU2</accession>
    <name>A0A139SJU2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="9" type="ORF">AXK12_06880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712706.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06880"/>
    <dbReference type="EnsemblBacteria" id="KXU34806">
        <property type="protein sequence ID" value="KXU34806"/>
        <property type="gene ID" value="AXK12_06880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="204" mass="23594" checksum="BB0ED6C67E496AFD" modified="2016-05-11" version="1">MARYTGPTTRLSRRFNQHILGSAKALERRSYPPGQHGPRLRRSKQSEYAIGLNEKQKLRYTYGLLERQFRRLFEKAKNERGITGERFLQLLETRLDSVVYLLGIAKSRAAARQFVNHGHIRVNGHKVDIASYAVQAGDEIEVRNAPASRQLATRNLEENRMRNVPGWLTMDSETLKAKVARLPNRDEMEPGINEQIIVEFYSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV7</accession>
    <name>A0A139SJV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712754.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06950"/>
    <dbReference type="EnsemblBacteria" id="KXU34770">
        <property type="protein sequence ID" value="KXU34770"/>
        <property type="gene ID" value="AXK12_06950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="101" mass="11398" checksum="C76EBB06AC354CA9" modified="2016-05-11" version="1">MRLGWTTLSERADAEKLARAAVAQGLAACVKIEGPICSVYRWQGKVEEALEYRLCFKLLPEHSAALEALVHRLHPYDIPEWVCVDAAQISEKYLSWAQQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJW9</accession>
    <name>A0A139SJW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712540.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06435"/>
    <dbReference type="EnsemblBacteria" id="KXU34872">
        <property type="protein sequence ID" value="KXU34872"/>
        <property type="gene ID" value="AXK12_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="430" mass="47355" checksum="34E97C38A3B0CEB9" modified="2016-05-11" version="1">MPPIKHSSLDRVLGRLDMLDSVNLTNLVQRLARERGLFEDIFNTLQEGVLVIAPSGEIEYANAAAHRLLGQPEDALLGKVLWRLVPGLQASLGVELGAQREVDASASSAQTRAGKGSGFTPPASSAAMPVMTREFELSYPELRTVQLYLVPFTESAAGVPRSTVILTDITRTKQSTEERIENERTSSILLLAAGVAHELGNPLNSLTIHLQLINRKLRRLGLNEANTAHAPPSRDLESLGESIRICEDEVKRLDGIITHFLEAIRPKPPDLRETNLSALLAEVLSFQQRELADREITVEAETRADLAPVMADQNQIKQVFFNVIKNAVEAMQPGGRLLIQAREDDEAVYLAFADSGAGIKQEELTRLFQPYHTTKIGGHGLGLMVVQRIMREHGGQIGIESKEGIGTVVTLRFPRKDRRIRMLEASHSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX0</accession>
    <name>A0A139SJX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712728.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06910"/>
    <dbReference type="EnsemblBacteria" id="KXU34817">
        <property type="protein sequence ID" value="KXU34817"/>
        <property type="gene ID" value="AXK12_06910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="308" mass="34324" checksum="D37887BA36A46388" modified="2016-05-11" version="1">MLLKLVSDSTRLRLLALFLREELSVAELQEVLDMGQSRISSQLALLRQGGVVNDRREGKKAFYSLHASLPKVQLDLLHAALATVEGQMPELERDAENLERVLQKRRRTQEQYFSRIAGRFDKYYAPGRSWKAFAQLALRLTPEIAIADLGAGEGLLSQLLARRASQVWCIDNSPRMVETGTELAKKNGLDNLSYKLGDIEQVPLPDASVDLAILSQALHHAPHPQKAVAEAYRILKPGGQLLVLDLQEHDFEKARELYADHWLGFSENTLHSFLARAGFTRVEVAVVDTEPDEPHFTTLLASGTKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJX2</accession>
    <name>A0A139SJX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_06480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712551.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06480"/>
    <dbReference type="EnsemblBacteria" id="KXU34878">
        <property type="protein sequence ID" value="KXU34878"/>
        <property type="gene ID" value="AXK12_06480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="15">
        <location>
            <begin position="53"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="899" mass="98978" checksum="873C5266D210B271" modified="2016-05-11" version="1">MKLIDSILKHLFSRFLARRRASGLFRRTAMPDAANFPRGATSIFDAITRERRRVASDDIAAALIRLESDMKGLSADEAEARQEKFGFNEIEHEKPLPWWRHLWQCYKNPFNLLLSLLALISLLTEDMAAAMVIATMVVLSTLIRFIQEARSNRAAEALKAMVSNTATVIRRGASPAKQMGIPIRELVPGDLIALSAGDMIPADCRLLAAKDLFVSQAAMTGESLPVEKFPDISQPFNAIFDAPNLLFMGTNVISGSATALVVATGNHSYFGALSVRVTSTGRVETAFQSGVNSVSWLLIRFALVMVPVVLAINGFTKGDWMEAFLFALSVAVGLTPEMLPMIVTSTLAKGAVKLSKQKVIVKHLDAIQNFGAMDVLCTDKTGTLTQDKIVLERHTDAFGEPSDEVLRYAYLNSYYQTGLKNLLDRAVLEHAELQTHDDRKVDEIPFDFNRRRMSVVVSEREDQHTLVCKGAVEEILSVCTGIRHDDEDVELTPELLKNVRALTQELNSQGLRVVAVAIKVMAKPQSNYSVKDEAGLTLLGYIAFLDPPKESAAPAISALEKHGVAVKVLTGDSELIAAHVCAQVGLERHGILLGGQVETMNDAQLAQAAQDYQVFARLTPHHKERIVRALRGNGHVVGFMGDGINDAPALRAADIGISVDSGVDISKEAADIILLEKSLMVLEAGVMEGRKTFSNMLKYIRMTASSNFGNVFSVLVASAFLPFLPMLPLQLLMQNLLYDISQIAIPFDDVDDELVAKPLRWNPGDIGRFMVFFGPISSIFDILTYLLMWFVFSANNVAAQTLFQSGWFVVGLLTQTLIVHMIRTPKLPFIQSRAAWPLLLMTGLIMLIGVCLPMSPLAGYFKLQPLPGSYFPWLVAILLGYAALTTLLKRIYIRKFGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK01</accession>
    <name>A0A139SK01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712521.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06380"/>
    <dbReference type="EnsemblBacteria" id="KXU34863">
        <property type="protein sequence ID" value="KXU34863"/>
        <property type="gene ID" value="AXK12_06380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112867" checksum="7B0AB9E12F5A3308" modified="2016-05-11" version="1">MARFFIDRPVFAWVIAIVIMVAGAVSIIELPVAQYPNIAPPQISIQATYPGASAKTLEDSVTQVIEQRLNGIDHLRYIESSSDATGNVSISITFNSEADPDIAQVQVQNKLALAMPLLPQEVQQLGVRVTKSVRNFLMIVSLVSTDGSMSAPDINDFVISRLQDPISRVKGVGEIQAFGSAYAMRIWLDPAKLTHFALMPSDVSAAIRAQNVQVSAGQLGGMPAAEGQRINATVNAQARLETPEQFGAILLKVNPDGSQVRLRDVARVELGPESYEISGRFKRMASAGMAIRPATGANALETIDAVRAKLDELKPYFPEGIEIFYPLDTSPFIRISITEVIHTLVEAVILVFFVMYLFLQNWRATLIPTIAVPVVLLGTFGIMAAFGFSINTLTMFGIVLAIGLLVDDAIVVVENVERVMSEEGLPPRQATQKSMQQIIGALVGIALVLSAVFVPMAFFSGSTGEIYRQFSITIVSAMGLSVLVAIVLTPALCATILKPIAKGHHYHDTGFFAWFNRIFDRGTNLYVNGVGGMLRRKARFFVVYLVVVVGMGWLFTLVPTGFLPDEDSGLLFAQAQLPPGSTYEQTMAVLEDIEDHFLETETENVYGMFGIVGFSFSGFGQNQAAAFVRLKDWSERKRPDQAVAALQGRFLQKFLPRKDALAVAFMPPAVMELGTANGLDMRLTDNAALGHEALTAARQQLINLANADPRFVNARSNSMDDTAQFKIDIDQEKAAALGIAISDINSTLSTAWGSAYINDFIDRGRTKRVYMRGDTTSRMKPEDLEQWHVRNNRGEMVPFSAFATGSWQLGAASLERFNGNPSTSIAAIPAPGISTGEAMTAITELAGQLPDGFGIEWVGLSYEERSAGSQAPALYAISILVVFLCLAALYESWSVPASVMTIVPLGIIGTLAAALLRGMPNDVYFQVGLLTIVGLSAKNAILIVEFAKAGFDNGMSLFDATIQAARQRLRPILMTSLAFGLGVLPLAISTGAGAGSRNAIGTGVLGGTFTATVLGIFFVPLFFVVILRLFRVKPNTLITAKKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK11</accession>
    <name>A0A139SK11_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4412 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712628.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34918">
        <property type="protein sequence ID" value="KXU34918"/>
        <property type="gene ID" value="AXK12_06725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025524">
        <property type="entry name" value="DUF4412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14371">
        <property type="entry name" value="DUF4412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299244" description="DUF4412 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4412" evidence="2">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="235" mass="25618" checksum="E58BE6A6298C298C" modified="2016-05-11" version="1">MPKRLRHLALATLALLSAALTPANAARAKSAAIKPFEGTATIKVTHDRVGTHVFDYKVKSSRLRTELEVSEGVRAVTIVDFFKNEVFVLLPGQPLFVTMSLENSAQVALGHNIDTVTIEPTRARKKILGYRCTKYLVRDESDAFEVWATDQLGSFMGLGLAAEADAKFAPPWVSALAGKGFFPLRVQSLPGSKNTLSMETLSVQQNAQADDLFVPPPSYREFQVGGLVEDLLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK16</accession>
    <name>A0A139SK16_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712609.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34909">
        <property type="protein sequence ID" value="KXU34909"/>
        <property type="gene ID" value="AXK12_06660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299311" description="OstA-like_N domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="3">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="199" mass="21178" checksum="3B0D86859770EEE8" modified="2016-05-11" version="1">MSHFCRRPVFGPIVFATLWCISLTAHGQTVNTPPPPTVIKCAGLSELISTDTETTATFSDSVVVTGNNLSLHCDFLKVVATRKGDPAATLGQYGNFKSLVATGNVRIVQGDREASCGRAEVFPGEDRIVLSENPIVRSLDGDYSATGPQLVLYRGQRRAVIEGTAEAPARITLPPIKDLGFDDETKAPRASTSSSGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK75</accession>
    <name>A0A139SK75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712455.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06195"/>
    <dbReference type="EnsemblBacteria" id="KXU34955">
        <property type="protein sequence ID" value="KXU34955"/>
        <property type="gene ID" value="AXK12_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="477" mass="52922" checksum="9033A3AD510F5F61" modified="2016-05-11" version="1">MKINSQITPQKLLKKTERVLELAGRKIRSIDASWDSAQGTPVFTVKGRYTSRGWTEWTQGFQFGMALLQYDATGEEAFLALGREKTLRHMASHVSHIGVHDHGFNNVSTYGNLRRLMLEGAMPFNQDELNYAELALKVSGAVQAARHATTDQREPWSPRTPKTGEGGGCRGLVPSGYLYSFNGPQSLFADTIRSLRALVLAHSLGHALMGEGDRRINLLHRAVEHAATTARYNVFFGQGRDAYDVRGRVAHESIFNRNDGQFRCPSTQQGYSPFTTWTRGAAWIICGYAEQLEFLETIGTGELRAVGGRAAVADLYLETARAASDYYIDGYSALDGVPYWDSAALNTHQLGDYRAHPADPYNAHEPVDSSAAAIAAQGLIRLGTYLKGRGDEAGARRYFQAGLTIADTLFAEPYLSTDPKHQGLLLHSVYHRPNGWDYVPKGQRIPCGESSMWGDYHALELALLIRRLSEGEYYTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK76</accession>
    <name>A0A139SK76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_06555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712577.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06555"/>
    <dbReference type="EnsemblBacteria" id="KXU34890">
        <property type="protein sequence ID" value="KXU34890"/>
        <property type="gene ID" value="AXK12_06555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="612" mass="68135" checksum="3F434D1E3B75CDCE" modified="2016-05-11" version="1">MQPSATSQESPSVIVGFDCCNRLAVLNRKDRLELPFYANALAAAVSKIETAFGSGSFTAPEPQFSAKLPPDADRENAGPVQVYFSQVRAVANAKSDIKFHSIESLEARASELAPELHALLALLEPHLLRIPYLHLGENDFIYKFRPEKERNVAIYANDDASSALYQSKLCELIKARARTREGSASAPVMLDFGPVAYHIPSHFGFCLGVKNAIERAYEALAANPGRRVFMLSELIHNPFVNADLLRRGLRYLQSDKGVAFSVDGKPRETPARENSSRTQANNEPPVPKGEQSRVLLWDTLTSDDVVIIPAFGATDEDKRRLVRKGVAVCQYDATCMLVEKVWKAARNYGRKGYTVIIHGKAEHEETKATFSNTRRYAPALIVRDLAEVRRLERIIAATTPAEAEAARAAFYEFFKGKHTPDFDPIRDLARVAVVNQTTLLVNETRAIIDYLRERYTARYGAEDAVERVGGSNKNDTLCYATQVNQDALAKALEGPLDAAFVIGGTNSSNTYQLYRLCENALGKRAHFIQSERDILSAHEVEHFVFPYERGAQAHKEHRPLWTNLEPKKHVLITGGASCPDGIIQQVITRLNGFFRPETLRPIDRLLAELEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK90</accession>
    <name>A0A139SK90_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hprK</name>
        <name evidence="13" type="ORF">AXK12_06650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712605.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06650"/>
    <dbReference type="EnsemblBacteria" id="KXU34907">
        <property type="protein sequence ID" value="KXU34907"/>
        <property type="gene ID" value="AXK12_06650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="139"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="273"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="324" mass="36371" checksum="74B1E5215C24868F" modified="2016-05-11" version="1">MKKDVHGITVGQFFATYGEKLQMELLTRSGMGLYRLIKEGSINRPALALTGFLKYFANKRIQVLGAAEMTYLKSLSPERSAFILREMARKHIPCLVLTRNYHPPLWMLEVAAQIGLPIFRTPMITMKYVNMATLCIDNEFAPTGIEHATTLDIKGVGVLLRGSSGIGKSECALALIQRGHSLVADDLTVVKLLDERELMATSRPLNRGWMECRGIGIINITEMFGIKSVRHQKRIDLVITLQEWTPEVQEERTGLEQAYYTILGVKIPYIELYVRPGRDMARLVEVAALVQALKTIGHDPAKDFNDRLIAHMTGQTPPNPLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKB4</accession>
    <name>A0A139SKB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_06420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712650.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06420"/>
    <dbReference type="EnsemblBacteria" id="KXU34927">
        <property type="protein sequence ID" value="KXU34927"/>
        <property type="gene ID" value="AXK12_06420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="369" mass="40903" checksum="14E4F405F0B4EB1A" modified="2016-05-11" version="1">MNNASPDNQAALTNRSDAFRSGLLAWYRRHARALPWRSAPTLYKTVVSEFMLQQTQVKTVLPYFARWLEALPDFAALARAPEAQVLKLWEGLGYYTRARNLHKLARVLVEMGIENDGNSTVPNAAAAATRWPIKKSAAPQTREDWLRLPGIGPYTAAAITSISFGARAAVVDGNVVRILARLTADATPYRDSSSAAKAYTPLADALLNPAHPGDHNQAMMELGATLCLRRKPLCLTCPVRSLCACVRLGHDAEDFPKLAPKLMEKLTLRRTWCIKNGQLLLHRSTAKSRRLANLYELPELPPDSPALVGPPLLTKKRSITRYQITEHIYAADAPHGPLPEDHEWLPLAELDKVTLSGPHRRWVGELLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD0</accession>
    <name>A0A139SKD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00175"/>
    <dbReference type="EnsemblBacteria" id="KXU35023">
        <property type="protein sequence ID" value="KXU35023"/>
        <property type="gene ID" value="AXK12_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299308" evidence="6">
        <location>
            <begin position="20"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="389"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="923" mass="101007" checksum="23668C0B0FF5FBA4" modified="2016-05-11" version="1">MALIAALVVALGLPSAASAQRVPASALLDGLDDDQVVTLAEMEVEAGQLQKHAYQGNMDLVRTENDIQPYSIIGRERIARSGATTVEDLLRQQLTMSTSFASSDNSPGGWTGSSSSFSLRGMGAAQTLVLVNGRRVAGVGSRGTAEGSDQADLNGIPLSAIERIEVLPASASAIYGSGALGGVINVVLRGNYSGNEFNARYETTDDGHASIETYNLTSSFQFEQGRSQLLLSVQSQVTKPLYGYQRDFQVRGRNRELVNNPDALYVPAGRTGNPPAGALVNIRSANGSPLFGPGSSHFTHIPVGYRGWQLDGLQPLIDNQGSYNLDLARGALNGFSGDIVLIGAVRSKSLNLSSSRSMTERFKLFFDGGASESRQRDVSTYYTARVATLAANSTNNPFGQAVRITYPARHIDRETAPDSFSVNRQKRAAVGFELSLPHDWKIVGDYAWSYSYVDRTYRRQYGSPTFAEAVNAGTVDLLRDTTSFETLIDPYSNLPHTTTKAWQGDTTLRAAGPLTAWYAGDITLASGVEHRELRSAGFPDYTTPRPPPTYRRQQIDSLYAEATVPLTSPDLGLRGLHSVDVQLALRHERFDVETAGNKFDTTVPTVGLRWLPVRDLMLRGSWGKGFRAPTYSQLADPTLSTTTSQVNDPRRGGEVSDIYTLGGGNPELQPETSRNSNIGIVWTPEFVRGLRLSADFYKIEKKNNLTSLGAQAILDQEATFPGRVIRDTPVAGDPYGVGEVLQVNTYAMNMLKMETAGVDLGARYWWQSAGAGEFDLGVNATLTDYYREQTAFNTPLVDWVGVPSRNSASPLDARFTASLLWNRQQWSAGWAAQYYDHYRLNPTSTAAILSQGSERVPSQTYHDLFVRYRLGARYRILAGLELTFGAKNIFDKAPPVDMSTSRYYSTLGDPRMRRLYVNLKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD7</accession>
    <name>A0A139SKD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712432.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06135"/>
    <dbReference type="EnsemblBacteria" id="KXU34944">
        <property type="protein sequence ID" value="KXU34944"/>
        <property type="gene ID" value="AXK12_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="140" mass="15789" checksum="974306B77E8B3BF5" modified="2016-05-11" version="1">MQVNDIPALNAGLNALATVLLTVGFIAIKCGKRELHRRIMIGACTVSAVFLVGYVTHKALVRGVHTPFGGEGAIRTVYYAMLLSHVLLAMSIAYLVPRTFLLAIRGDTVRHRAWARWTFPIWYYVSITGVLVYLFLYRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF1</accession>
    <name>A0A139SKF1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712377.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35031">
        <property type="protein sequence ID" value="KXU35031"/>
        <property type="gene ID" value="AXK12_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="452" mass="47585" checksum="91C6AF0B3F280BD4" modified="2016-05-11" version="1">MTNSITPLRFRSGFLLGKNRGSRRFCGFPLGRVASLTGVLAALGCGLFSASASAQDSGALVEALVRKGILTAQEAEEIRADLLREAAEPPAVATAGSSLTTRLRISGRIQTQFASIDTDISGTSDDPASTNHFFARRLYLTARADLGPNWASNITYDFAGSLFDAAWVQYKGSGFTVDLGLRKVNLGYEERTSSGSLKAIERSGVTRYFVEENNGRRLGAGSYRVGAFVDGKQGAFFYGAAITNPERAVNSGAAASAGNSTRNQFAFWANAGFSGPLGEGGDATYIVGAGAGYLPDQGGRPVGTGDDLTVYTVYADVRGLAGGRFGLAAELLGADVERGVSATRDASPLGYWVQPTFKVSEQFELVARYSALDSDGRGVSLSDGVRSAPGGGTHDKLREFFFGGNWYLRGNDLKLQAGYVHGESRDEVGGGGAGGVVRAKARGVRSQLQFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKI9</accession>
    <name>A0A139SKI9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712396.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00285"/>
    <dbReference type="EnsemblBacteria" id="KXU35040">
        <property type="protein sequence ID" value="KXU35040"/>
        <property type="gene ID" value="AXK12_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="365" mass="39864" checksum="B65C2CA339AD171D" modified="2016-05-11" version="1">MKVLLLSPAMFGREGGIERLMRLYLKALGEICEQEAGTVESLCLSDGRGGTGPGLLTAYSGKSLRQHRGFAHNKLRFALAVLRRARGSDLIVCGHINQLIVARVARLLNRKLRYCVVAHGIEVWRPYGLLERWALRGADRIFCVSEFTRGQMLRFDKRLTPSRLKVVPNALDPQLAGKDSGAGHNPPAAQRRPTILSVGRLTRSDSYKGFDTLIEAMPAVLGEYTEARLRIVGTGDDLPRLRALAAECGVAHAVHFLSRVGDEALRAEYAECSVFALPSRSEGFGLVYLEALTQGKPCIGAKAGAALEVIGETGGLCVGYGNVAELTAAIVELQRHPPEAVALRDRAQEFSFERFHERLAEALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW9</accession>
    <name>A0A139SKW9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="11" type="ORF">AXK12_05665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712132.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05665"/>
    <dbReference type="EnsemblBacteria" id="KXU35192">
        <property type="protein sequence ID" value="KXU35192"/>
        <property type="gene ID" value="AXK12_05665"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="10">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="219" mass="22424" checksum="060402A968D87A08" modified="2016-05-11" version="1">MRPSFDLSFYLVLDPALCGGYEATVRTALAAVAGGATMVQLRDKEASTSRMVETAQRLKAALAGSAALLIINDDVEAAIAAKADGLHIGQQDMPVAEARRRIGERMILGLSVETAERAAAIDPVRVDYAGIGPVFATPTKPDHQPPLGLDGLARLAALSPVPSVAIGGLKAIHAPAVFAAGAQGIAVVSAICSTPDPGAAAEIITQAIQRGKNLASQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL16</accession>
    <name>A0A139SL16_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG</name>
        <name evidence="1" type="ORF">AXK12_05655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712128.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35190">
        <property type="protein sequence ID" value="KXU35190"/>
        <property type="gene ID" value="AXK12_05655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="255" mass="26533" checksum="8610EA39F2467CF1" modified="2016-05-11" version="1">MTHPINQQIVLVTGAGRGLGAAIARAFLREGATVVLNYLHSETAARALAADAPGRAIALQADVTDPQAVAAMLSAARRALGRPVTTVVNNALPDFRFDGDARPRPEALDWARMNQQMQGVLGGALHVVQAALPGMREAGGGRVINIGTNLFQNPVVPYHDYTAAKAALLSLTRTLANDLGPDGITVNMVSGGLLRTTDASAATPEAVFDLIAANTPLRQVTTPAQFADAVLFFASPWSRAVTGQNLIVDGGLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL21</accession>
    <name>A0A139SL21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712271.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06015"/>
    <dbReference type="EnsemblBacteria" id="KXU35253">
        <property type="protein sequence ID" value="KXU35253"/>
        <property type="gene ID" value="AXK12_06015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="312"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="389"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="701" mass="77416" checksum="FBD39E1B5046495E" modified="2016-05-11" version="1">MRTKVTLVLIFLNAALFVFIFKFERGWRTDQAQREARRRVLGPETASIQQLRISGPSLTTIELVRSGAQWSLTSPIDWPANPHAVNRILNELQFLEHETSFSVAELEKNKQSLADYGLEPPRLTIEFTPASTPISSIPATHTEPQRITLQVGDETKVGNRLYLLSPQRDRVHVVGLSLARSLNLPLEELRTDDVFSIPLFEARSLTLQNASASRVRIRQDGKHWSFEAPIIARANKPQVELTIAALNALRVHHFLPTGTASPSTPTTNAELRISLVGNNRQETLILLNEIEAAAPTAASEAEARTVSFVAALEGKTTRFVVEVPQPLLNTLRNAQDTLREPRILDFAPEALTAVTLSAPNQAPLTLQQLRSSADGQHTWQIIRSNTAQGPQLQPVDPQRMRELIQTLRRLSAQRFVSDAPSDADLENWGFNRPERKITLTLNPPANSLNTERESALGPVAEPQTLHLQIGRPTEPSPQVYARLSNARFVYAIPAELLEQTAPDPLNYRQHLLRELPETARFHSLTLTDLNSGAIVFETSVDDEAAAAETPAKGDGETPPASQRTRLFATLRRLEAASFIQDHFSETVFAAGAERPWRWRLDTTVRLPSGHGDEQSETSSLFLTERLGGDLQLAGSPQLGLVFAINQALLDALWPLTYRERSTEETTPAEPPSTGEAHPVSEAAPSSSTEEAPANASPNQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL24</accession>
    <name>A0A139SL24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712192.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05810"/>
    <dbReference type="EnsemblBacteria" id="KXU35217">
        <property type="protein sequence ID" value="KXU35217"/>
        <property type="gene ID" value="AXK12_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="733" mass="79264" checksum="C55188DF782FEF52" modified="2016-05-11" version="1">MKPYTHVNYLWDEAKAAALDPVERLVYRSNLLGSDQRITNTGGGNTSSKLIERDPLTGEPVEVLWVKGSGGDLRTSKRENFASLYQSKLLGLQAIYAAANPEGERGLKSQAEDDMVGMYTHATFNLNPRASSIDTPLHSFLPGKHVDHMHPNAIIAIAASERCEELVREIFGGEMAYVPWMRPGFELGLAMQEIARANPGLQAIMMGQHGFISWADDDRACYTYTLDCIEKAAAYIEKKYAEKGGDAAAFGGAKYHALPEAERRATLAALLPWLRGQVSQQRRFIGTIQEDAAILRFVNSHDAPRLAELGTSCPDHFLRTKIKPLYVDWNPQAEDLAALKAKLAEALESYRADYAAYYAACKRPNSPAMRDPNPTVVLIPGLGMIAWGKDKSESRVTAEFYNCAVEVMRGAEAIDRYIALPQQEAFDIEYWLLEEAKLQRIPAEKELARQTIIVVGAGSGIGKETAARLSREGANIVCVDMRAEAAQATAAEISARLGSGIGVAGSGISGCGPAIGLAADITDRASVRTMLDAVALAYGGFDSIVVTAGLFWPSDTSGRIPDDKWALTFGVNVTGSYIVGDEAAKTWREQGLKGQLVLTTSANAAVAKKGSLAYDTSKAAANHLVRELAIELAPLVRVNGVAPATVVQGSAMFPRDRVIGSLAKYGIAYAEDEATELLVAKLAQFYADRTLTKSPIKPADQAEAYFLLVSQRLSKTTGQIITVDGGLHEAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL31</accession>
    <name>A0A139SL31_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purU</name>
        <name evidence="5" type="ORF">AXK12_06055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712283.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06055"/>
    <dbReference type="EnsemblBacteria" id="KXU35259">
        <property type="protein sequence ID" value="KXU35259"/>
        <property type="gene ID" value="AXK12_06055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="307" mass="34396" checksum="41163F1F84053F1B" modified="2016-05-11" version="1">MTSAPISAGSSPVPASQARLRLIASCPDRVGIVARVATFLAERGASITEANHYHDASSQWFFMRSEFAISVGGAEQRQALLAGLADEFRPIAEGFDMEWRFTDAQRPQRVVILVSRFDHCLAHLLHRWKSGDLPYDLPCVISNHDDLRSLVEWYGVPFHHVPVPRDAAGKEAALKRTAALMDEVAPDTIVLARYMQVFPPWLCARYPSRIINIHHSFLPSFVGGRPYHQAEERGVKLIGATCHYVTEQLDAGPIIEQDVVRIRHSDTIKDMMRLGKDVESAVLARGLRLHLEDRVLVHGHKTILFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL35</accession>
    <name>A0A139SL35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712156.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05735"/>
    <dbReference type="EnsemblBacteria" id="KXU35204">
        <property type="protein sequence ID" value="KXU35204"/>
        <property type="gene ID" value="AXK12_05735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299329" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="781" mass="84672" checksum="29BE61A97820A7C0" modified="2016-05-11" version="1">MKLSFCSSRLLALAAASAAAVPFTLAQSVPDSPPADAVEISVARPRAEADTVTLSPFEVSVNQPARYQADEAASGGRIRTQVMDTPSTVTVLTNEFLEDVGGNRIIDAALYVAGVSEATFPNGLDAVNIRGFQSTGRRIDGFSTFAQANFDPAVVERMEIIMGPDALLSPTGVPGGTINLVTKRPQFTSGGYLKLRVGQYDANRIETDLTGPIGERFAYRVIAAVQDSEGYVNDTFTKSYLFSPSFTWQLAPQSQLTVRYEYYDAETSNLEGIPVDPAVGTDSDFRTLPGVPRDFNSAPDDKYSFRRGLTHALNFLFTSTVTDRLSVRLAGRIGEVDTPNSDFRWGLSTPGGSYNPFTGRWEGGTIWTNTSSDPAAPNWVSAPAPALSDTIRHQGTYSGARRRERDLQNDWSYIVDAAFAKSTTLLGFAYSYGHQNSYNNTQRLPDFTVPGFERPSGPPISNPITTDSRGATTRYQAYLSEVLELFNRRLVLSGGISHVSFNGFSGNKLAAATSTTVAGQAFPTSGSKATYNYGIVLKPFSKLSVYYGHSESAVPSGGRAVYEGTRPPFSTGKQDEVGLKVQLFENRLLASVAYYEIDQSAYSVFNPENLRVPPPPVLLPDLVSSREASGWEFQVTGNITPNLSVVASYADTRNRTPYGVVLRGSPEDSAAVFVRYGVTHGALAGLSAGIGANYSSKRAGDNPPNRFAVGSTPENPIPYQPSFYLPARTLTNAYVSYRRGSWDYRLEVTNLTDEDHYASLSRSIVQVGAPRAFSATVTYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL66</accession>
    <name>A0A139SL66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ORF">AXK12_05510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712082.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05510"/>
    <dbReference type="EnsemblBacteria" id="KXU35306">
        <property type="protein sequence ID" value="KXU35306"/>
        <property type="gene ID" value="AXK12_05510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="192" mass="21812" checksum="532B836553119950" modified="2016-05-11" version="1">MASDIIAPVTAQWFALHTLAGQENKVKTYIDKFKSIEELDDHIFEVLLPTETVSEGKHGKKTTKVRKLYPGYVFIHMHLYDEEHNVINKPWYFVKEVTGVIGFVGGERPAALKQADVDEIFARIAAAQGTEVPKVQYTVGEEVRITDGAFTNLTGRIDEIDPERSKLKISVSIFGRFTPVELEYWQVQRLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG4</accession>
    <name>A0A139SLG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">AXK12_05350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712002.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05350"/>
    <dbReference type="EnsemblBacteria" id="KXU35396">
        <property type="protein sequence ID" value="KXU35396"/>
        <property type="gene ID" value="AXK12_05350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="211" mass="22107" checksum="731A1AE8C19405B7" modified="2016-05-11" version="1">MSRPNPDDLRQTTHTPPSTDSSGSAAGDAEAASAAAAAPVDETEHAAASADPIAAAKAEAAAIHDRYLRAVADHENFRKRVAREKDELRQYAASRVLEDLLPVLDNLGLGLAAAEQPNASVKSLREGVAMVQTQLKTALEQHGLKEINPAGQPFDAHQHEALSQAPSTEVAEGDVLQVIRVGYSLNGRLLRAASVVVSSGAPSTTHSEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG5</accession>
    <name>A0A139SLG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711982.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05295"/>
    <dbReference type="EnsemblBacteria" id="KXU35387">
        <property type="protein sequence ID" value="KXU35387"/>
        <property type="gene ID" value="AXK12_05295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="257" mass="29416" checksum="F8CD5E7BFF05B044" modified="2016-05-11" version="1">MKAVILAGGFGTRISEESHLKPKPMIEIGGRPILWHIMKIYSAYGVNDFVICLGYKGYLIKEYFSNYFLHMSDITFDMKENQMEVHQEHAEPWRVTLVDTGESTMTGGRLKRVEPYLDKTEDFCFTYGDGVSDVDINKLVAFHKAHGGLATLTATYPPARFGALDILPNHQIGHFKEKPKEEERTINGGFFVLSPKVLELLEDDACVWERGPMEALAQQGKLFAYPHRGFWQPMDTLREKTLLETLWNEGKAPWKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLG8</accession>
    <name>A0A139SLG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AXK12_05390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712014.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05390"/>
    <dbReference type="EnsemblBacteria" id="KXU35403">
        <property type="protein sequence ID" value="KXU35403"/>
        <property type="gene ID" value="AXK12_05390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="307"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127200" checksum="FA5C9ED96E7E8831" modified="2016-05-11" version="1">MTTSTLEYDLALKKTVHTPVEQKPHYPWREALEGGEAAAELSLPPPPVTLLCPHGEEPFELAEVADTLGKALTNVRLAKGQKDIFNDESRAWVRRICRELSENLASLAREQGPLKLTLAELYELIEKTLVDNDEYSVAKSLLLNRSRKLSLIDRPAASPAVTNSGLRVIRRNNQVVPWRAQKVELALRKTFLSLETDSAPAAAITRAVTERVKASSQALIHIEEVQDIVEEELMKSGHYKVAKAYIQFRERAAALRAAASGAASAAGSIGADTGDGVGLGLATGESAASTDADGVPTTIPAGQETLVMVKKPDGSNVFWDGADLKKRIEFASLGLDLCLSAEEIEAELRRAVYDQITQKDLDATIVLNSKTLIEQDADFAKFAGRIQLSYLYEEVLGWDILRDGIGALKTAHQRAFKRYLEHGVAIKRLNPRLLDYDLGALAAALDPSADLEFDFLGIQTLYDRYLIVDKTSTPARRIETPQFFWMRVAMGLMLDEPTETREAKVAALYGLYKGRRFCSSTPTLFNSGTLHSQLSSCYLYYVDDSIEGIMLRGIAENAFLSKWAGGLGGSWTAVRGTGAYIGGTNGESQGVIPFLKLHNDQLVAVNQGGKRKGSGCAYLESWHNDIFEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRMEARESWTLFRSNEVPDLHDLYGKAFEDAYLRYEQLAEAGKIYGQKIQAIDLWKRILSMLFETGHPWITFKDPCNLRSPQDHVGVVHSSNLCTEITLNTSNDETAVCNLGSIILENHLLPDGGLDHAKLRETIRIAIRALDNVIDINFYPTEAAARSNQRHRPIGMGVMGLANALYLKGVAFASEAAVEFNDEAMEAIAYYAYEASSDLAAERGTYSSYKGSKWDRGLLPQDTLDLLERERGLQIKVPRGGLMDWEPLRAKIAKQGMRNSNVLAIAPTATISNITATSPCIEPTYKNLFVKSNLSGEFIVLNPFLVRDLKARGLWNRQMIDHLKYYDGELGDIPGLPADLKEKYRTAFDIEYRWIIEAAARRQKWIDQSQSVNLWLKTPDLKILSHMYRHAWHTGLKTTYYLRSAAASTIEKATVSVKKEVRGAVAGAAGSVGAGATVGSPVGATSSVNGVGGAGAAPRVYSAAEKLACSIEAMRNGEECEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM77</accession>
    <name>A0A139SM77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L3 N(5)-glutamine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_04745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04745"/>
    <dbReference type="EnsemblBacteria" id="KXU35678">
        <property type="protein sequence ID" value="KXU35678"/>
        <property type="gene ID" value="AXK12_04745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017127">
        <property type="entry name" value="Ribosome_L3_Gln-N5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037167">
        <property type="entry name" value="Mtase_YfcB_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03533">
        <property type="entry name" value="L3_gln_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="4">
        <location>
            <begin position="156"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="335" mass="36823" checksum="B2FB1117A9C10537" modified="2016-05-11" version="1">MNSSAAAKNVAGADLFGGAALKPSAQAFAREAQRLATPGEWLRFAEKCYEQHRLALGQIATNAHDEALYLILHTLGLPMESDERVLTRRLCAEERAALAEVFRRRIFEHMPAAYLTREAWLGEQRFYVDERVLIPRSYFLELIGPPLAELLGRPREAQRRVVDVCTGSGCLAILLAQYFPNARVDGIDLSADALDVARINVREHGLEARVALHESDVFDALPLPKSASEKYDLILSNPPYEPSAHCDALPVEFTREPRLALDGGGDGLDIIRKLLAQARARLAPDGIVLIEVGGLQEAMEREFAALRPQWLPTEDGSDCVCLIAAQHLEGLCPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM79</accession>
    <name>A0A139SM79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711783.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04775"/>
    <dbReference type="EnsemblBacteria" id="KXU35683">
        <property type="protein sequence ID" value="KXU35683"/>
        <property type="gene ID" value="AXK12_04775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="123" mass="13382" checksum="351124811C900D69" modified="2016-05-11" version="1">MNRFLKRAIRGLVRLPANGLLALVRLYQKTLSPVLPVIFGPACGCRFYPTCSHYAAEALQSHGALRGTWLALIRLLKCTPLHPGGLDPVPPPKQMRSGPSAARMSCTRVTHAPPFPTTLRTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM84</accession>
    <name>A0A139SM84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711791.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04800"/>
    <dbReference type="EnsemblBacteria" id="KXU35688">
        <property type="protein sequence ID" value="KXU35688"/>
        <property type="gene ID" value="AXK12_04800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="43023" checksum="B8D4540A68180C3F" modified="2016-05-11" version="1">MRIYDRHLLREWLQVLGLVLAAMIGLLLVQVLYDDFRMLSDQGAVARDFSLYVLVTLPGFLAIVLPVALLLSLLYTLGRLHRAGELVALRAAGVGLLRITAPVWVVGLGMCAVTWGLNASVVPWSVETSRALRDSLEFRRQAESAFQEDTIGAVRRVAFDNRAAASAGHGGRLWFINRYSQFTQRGYGVTVSVFEELGEPMDGAAAVEGLSERLESRRIVAAAAWRDEAAGGWVFADGQELFFDTKSGEIRGLSPFAQLIERSFDEEPDLMLMVDRRPADLSFLELRRLIDYYSAEGNPKGVAYAVRYFGLVADTFAPLVVIALAIPFAVSGVRMNPAVGVSKSIGLFFLYYVLMNVGTSLAVKQVLEPALAAWLPNAGMAAIAAWLFARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM98</accession>
    <name>A0A139SM98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711847.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04905"/>
    <dbReference type="EnsemblBacteria" id="KXU35662">
        <property type="protein sequence ID" value="KXU35662"/>
        <property type="gene ID" value="AXK12_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="455" mass="48332" checksum="D22E6669FF5433E9" modified="2016-05-11" version="1">MSLISINPATGQRIHIYGSHSSVQIEAALRQSRAAFGGWRETAPETRSAALRSLAHCLHTQADDLAALITAEMGKPITQARAEVEKCARVCEYYAKYGAAYLAEEHPHGAPRQARVVYEPLGPVLAIMPWNFPLWQVFRAAAPCIMAGNTVLLKHARNTSGCALAIEQIFHDAGLPHGLLQTLLVPTQSLAALIADSRVAGVTLTGSTAAGRAVAAQAGAALKPCVLELGGSDPYLVLDDADLDRAAEIGAHARLINCGQSCTSAKRFIVHAKVRAAFQRKLVKAISAYRVGDPLDPKTQVGPLARHDLRDTLHAQVTRSVALGAKCLLGAEPIPGPGFFYAPSVLAEVRKGMPAFDEELFGPVAVVIEAQSDEEAVALANDTPYGLGAAIFTRDRARARELVPVLDAGMVFINEAVHSDPTLPFGGVKQSGFGRELGPPGIRAFVNTKTVWISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMA6</accession>
    <name>A0A139SMA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrD</name>
        <name evidence="12" type="ORF">AXK12_05030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 10">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711882.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05030"/>
    <dbReference type="EnsemblBacteria" id="KXU35614">
        <property type="protein sequence ID" value="KXU35614"/>
        <property type="gene ID" value="AXK12_05030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="488"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="601" mass="63293" checksum="9EA9CF3E2A8B21DD" modified="2016-05-11" version="1">MSVGTETEPWAQPILSAAEVGEFEARIFGGDETQTREWSASGALARSASSAKAWAAMQAAGRALADAVLRDFEGIGGFPKNAGRLLVLVGKGHNGGDALIAAEAILGKYPSVVADFVFVFGEPALRPLARRAWLSLQTRFPERMQVLARRGLSERVTTHQSAHLAVHGEVKRGSRHMEPKAPLACGGEAPTAGSEFFTTGAPYALCLDGVFGFQFRPPLDSGTASVLAAAGALSVGLRAAVDLPSGLGEAGAFRADFTYATGVLKREALGLRNAGRLRYLDLGFFKNANPESRSAERVITAEVLAPLRGWRDPHSDKRAQGHVFVLAGSREYPGAALMCVLAALRSGAGLVTAFVPEAFVSSFAASVPEAIWVGWPETPNGGLALEGEYLLRERLARAGEKRALVIGPGIGRERETQVLVGEVLKTYSGELPVLLDADALQPEFLEKTRGPLVLTPHAGEFRRLSAAEPSDASLRDFAQRVGAVVVLKGPVTRVCDGSPRRDSCLNRGVSGEGSGEREGASALPVYHSLLGGPVLARGGTGDLLAGMIGAQLAREPSAILEASCRAVAWHGLAAEALERAQGAETVRTTELLNYLSLALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB0</accession>
    <name>A0A139SMB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711763.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04715"/>
    <dbReference type="EnsemblBacteria" id="KXU35672">
        <property type="protein sequence ID" value="KXU35672"/>
        <property type="gene ID" value="AXK12_04715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022265">
        <property type="entry name" value="CHP03790"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03790">
        <property type="entry name" value="TIGR03790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="448" mass="49236" checksum="5FB7F43F37A0A21B" modified="2016-05-11" version="1">MAHANISCALRRRGPRLKEALDAAALCDTLRRVLSRFFCLIVFGLLVGLGFAASPVRALSEDAALAARVVLLANANDQDSLRVARHYAAARAVPEDNIVSLPLSREETISWEDFVRTLWQPLQDELVRRGWIDALQGRRLDPAGRRKVAASGHSISYLVVCRGVPLRIANAPELIIPSGDIDPREQFRTNAAAVDSELSLLAYGDYNINAYLQNPFFRGSVDGAAGGLAQGRRRSAALLSERRVIKVARLDGPKLADVLALIDNTLLAEERGLRGRAYVDARGPHAEGEAWMEQIAARAQELGFPTEVNREEGNFPKEAQFESPVLYFGWYAADVEGPFMRPKFRFEPGAIAVHLHSFSAATLRSESKGWVGPLIARGAVATTGAVYEPYLELMHRSQLMFEELTKGTRLGDAAYAALPVLSWQSVLIGDPLYRPFKRKPTAARAVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB1</accession>
    <name>A0A139SMB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04730"/>
    <dbReference type="EnsemblBacteria" id="KXU35675">
        <property type="protein sequence ID" value="KXU35675"/>
        <property type="gene ID" value="AXK12_04730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299346" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="71" mass="7599" checksum="738E143AFB11E75D" modified="2016-05-11" version="1">MFRAPLAVLLVAAFAFAFSITAASAASAPVPQNVIVMINAGAGWGTWDATAYWQYGSREVERFEESARATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMM7</accession>
    <name>A0A139SMM7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711730.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35843">
        <property type="protein sequence ID" value="KXU35843"/>
        <property type="gene ID" value="AXK12_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025512">
        <property type="entry name" value="DUF4399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14347">
        <property type="entry name" value="DUF4399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299355" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4399" evidence="2">
        <location>
            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="148" mass="15647" checksum="83BE346AA7DBC539" modified="2016-05-11" version="1">MKSITRSFLFAFALGLLPVGAALTATTAVATPSAEGAEVYFISPKDGDTVRGPVVVRFGLKGMGIAPANIEMPGTGHHHLILDAPLPDLSKTIPTDDNHLHYGLGQTEVELSLAPGKHTLQLLFGDHLHVPHSPAVFSEQITITVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMV7</accession>
    <name>A0A139SMV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">AXK12_00095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711740.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00095"/>
    <dbReference type="EnsemblBacteria" id="KXU35849">
        <property type="protein sequence ID" value="KXU35849"/>
        <property type="gene ID" value="AXK12_00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="636"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="870"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="873"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="545"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="933" mass="104007" checksum="3825761B64F61241" modified="2016-05-11" version="1">MSEISKSYEAREIEQKWYAAWSAAGAFEGRAEAGKPAFSIVIPPPNVTGVLTMGHVLNNTLQDVLIRRARLEGKSALWLPGTDHAGIATQTVVERQLRAQGQTRHDLGRDAFISKVWDWREEKGGIILEQLRRLGASCDWARTQFTMDADYSRSVLTLFVELFRKGHIYRGRRMVNWCPVSKTALSDEEVIMKPSKGFMYHVRYELIARPGEFITVQTTRPETIAGDVAIAVHPDDPRYTALLGQTVRRPLGPPAEIPIIADSAVDKDFGSGALKITPAHDKVDFEIGQRHGLAQIDVLEADGTVNALVSPELAGLDRFVARKKAAELLAASGALVKAEPYENNVGYSERADVPIEPRLTWQWWLRYPRVEEAKAAVRDGLIKFYPARWAKVYLHWLDNLHDWCISRQLWWGHRIPVWYRKGLDIESLSEADLRDPQKLHVSLDGPPDPENWVQESDVLDTWASSWAWPFATLGWPDEAAMQRAGFDAFYPTETLVTGPDIIFFWVARMIMAGLEFTRPGEPLARRIPFRNVYFTGIIRDAQGRKMSKSLGNSPDPLDLIAKYGADGLRFGILSIAPQGQDIRFQEDRIEGGKNFCNKLWNACRFRQMSGQSARGSNASLEAILARLAPAHFDADDHAIFARLIETSAEVEKCFAHFEFSAAVQHLYAFFWNDFCDWYVEVSKAKLQDDARKEGCLALQDLVLRQLLLLLHPFIPFITEELWQLLGYAGVDSASEAAVTTGERARRQEPGLRPFIEETRIPSAAELRAAAESRGLVIDAQAVETVAKLKALVAQARTLKAENGLSSPKKTFFRLKVDAEQAAIVEPNIAKLLRLIGAAEITLCESISGSASAVTALGTLALEFDESFDPAAERARLTKELDTLAKHIAATEARLANPTFAEKAPPAVVEGARRQLANQVAKRDELTRLLASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMY7</accession>
    <name>A0A139SMY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35963">
        <property type="protein sequence ID" value="KXU35963"/>
        <property type="gene ID" value="AXK12_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="223" mass="24632" checksum="7E18626748CED5EF" modified="2016-05-11" version="1">MKNENLAPTPTRANARTQKKEACDLDLHFINALFAHLTGHDLYLAAQIKDAIRFNLEELEAKFNDDAAAPALGDGSAETSAKALAAKPALCTPSGAAPSHKGACASFYQAATRLLKTTLGQHFPQRGFYHWDAAQTLASATPLFARDEILNGLKTLAPYRDSTLLITNLRPALLAPPPRRRGFRARRRPSPKRLRDYEELIDFIRHLSAAHTAPDKRLQILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN43</accession>
    <name>A0A139SN43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36033">
        <property type="protein sequence ID" value="KXU36033"/>
        <property type="gene ID" value="AXK12_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="77" mass="9066" checksum="1751BBCC1BE8182A" modified="2016-05-11" version="1">MFKIDIFIILRIQKMGVFTFPWVKMANFSILVRQYAIRRLSIIGDGDRNRNSVFSNWSILLEFFVNSNKVCTCIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN87</accession>
    <name>A0A139SN87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711482.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04040"/>
    <dbReference type="EnsemblBacteria" id="KXU36009">
        <property type="protein sequence ID" value="KXU36009"/>
        <property type="gene ID" value="AXK12_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="503" mass="54857" checksum="5076C577046E832F" modified="2016-05-11" version="1">MPDSTSLQQPEHYDVAIIGAGMSGLAAGIRLAHFGKRVCIFERHNAIGGLNSFYAIGGRKYDVGLHAVTNYVRPGVKGTPLTKLLRQLRIDRDEFALCEQRQSRVSFGPRGECTLQFNNDFALLESEVAKTFPAQIDGFRALVETIRSYDDVSLDAASVSARAIVRRHISDPLLEDMLFCPVMYYGSASAGDMDFGQFVIMFKALFFEGFARPLDGVRVILRVLLGKYRDAGGIRRMKCGVQKIIARGGRVAALVLDSGEEVLATHVLSSAGAPETFSMIREGEISEAGSAVTPGAVVPNESVGGSGAAAPNGKAARPHSFVETISVLREQPAELGWGEDTIVFFNESEKFAYGCPESQVDVRSGVICLPNNFAYPEGQQLSEGLVRFTCLANPQKWFGLPEERYRADKAQWFAEIEKSARRFLPPLAKTPEVLATDMFTPRTIHKYTGHVNGAIYGSPEKIRSGRTHLGNLYLCGTDQGFLGIIGAMLSGISMANYHILAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN97</accession>
    <name>A0A139SN97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711529.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04180"/>
    <dbReference type="EnsemblBacteria" id="KXU36029">
        <property type="protein sequence ID" value="KXU36029"/>
        <property type="gene ID" value="AXK12_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299361" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1252" mass="137564" checksum="7906D06953EB7F33" modified="2016-05-11" version="1">MTTLLFRVRGARLACAAIAACALLFSARLTSPASAQALPPERAAAAHAADDELFILTPFEVSTGNETTGYTAATTLAGNRLNTQLRDVGSAVTVVTEELLRDIGATDNRSLLQYTVGTEVGGLRGNFAGLGDGSALSEDLLAQNSNTRVRGLSAADNTRDYFRSSIPWDAYNIDRVELQRGANSILFGQGSPGGIINTGLKSAQFRNFGEAAFTVGSHGTTRSTLDVNRVLLPKELALRVSLLHGDERYRQKPAFSEDSRVYAALRYEPRALNRGGVRTTIKANFESGRIRSNAPRMLPPTDGLTPWFTELGQRTYDQFQAFDHLSGRPVSGQWRRNLFTTGGPNPDYEPWAAIFTAGNGTTVFSPGNGAQDRWVTAITGAFLRGGLDASGALDGQFASIPDNGLITITPTGQWAINANAPYAAAGVWKNNVLTDTSVFDFHNRLIDGDTKRERQKFGVGNLSLSQTYFDNRIGLSIDLSKESYDSEKRATLPGEVVLQIDPIRVFGDGSPDTGLIPGQRPYADGTPNPNLGRVFTATNNTQGNRRSETEQTAARATAFAQHDFSDKGRAASWWARALGQHTLTGLVGRERAKSDAREWQRYGLFDNDYYALSGRAGNRFDTFAPLQILYLGDSLLGRDLAGASLPTLGNGNVLTSGPIRYFDSTWNAVGVNPGDPWLNGFYLDPSAQRSTQSENPANYVGWTTTQLNIVDADQSAANRARLTRRATLDKSTVESRALVWQGKWLDNALISTIGWRRDIAKAWSFDMTPSDFPVLPNRGQLDFGNYRLGNDASRIAVESKSYSFVAHLNDLPGLRDALAWLPVNVSLFHNRSQNFKPDASRVGIYGEPLPAPAGKTEDRGLRIETKDGRYSLRVTRYRTSNSNASSAQINAASIGQWMAFTQNFANVFEYNIKPWAFDATAPGATGSDTDIYDSATGDESAMRYNFHFFANRPLEPGEFLSGDGKWIVSPAREKAVVDATRAFQRSVDPRFWQAWRINTFGDFGPPDGQTPYSVPAGFSITEDNISEGWEIELSAQPTKNWRVMLNASQTEARRVNVGNANMRELMGLINDALKIPNGVARMHHYYGTEDVVTAGKNWFDGEGLSGAPGSEWRRAQLYENTTVPELREWRVNVITNYEFDKTALKGVNIGGGVRYQSSIALGYPPTGDPNDPLKIEYDFSRPYKGPAETNLDLWIGYSRQLTRKLHWKVQLNLKDAFERPGLVPITYNPNGRPAAYRITTGQSWSLINTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB1</accession>
    <name>A0A139SNB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="8" type="ORF">AXK12_04300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711570.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04300"/>
    <dbReference type="EnsemblBacteria" id="KXU36049">
        <property type="protein sequence ID" value="KXU36049"/>
        <property type="gene ID" value="AXK12_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="87" mass="9106" checksum="227B257DC0B50D32" modified="2016-05-11" version="1">MANTKSAIKAARKTVRLTARNKATKTRLKTLHKKLDAAAKAADPTALKTAAANYASAMDKAVKSGVVHKNAANRAKSHAAIKLKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF1</accession>
    <name>A0A139SNF1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_04535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711652.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04535"/>
    <dbReference type="EnsemblBacteria" id="KXU36089">
        <property type="protein sequence ID" value="KXU36089"/>
        <property type="gene ID" value="AXK12_04535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TOP_N" evidence="11">
        <location>
            <begin position="54"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="10">
        <location>
            <begin position="229"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="686" mass="76522" checksum="6A77C461E236A648" modified="2016-05-11" version="1">MQALSSPNPFLDSVFEVRWQRCRPECVEPAIVEALVEARGEIEKIATQPLEGLSFESTFLALEKATERLGTAWGLVTHWQSVADSPALRQAHNAMLPQVSAFYSSIPLNPELWRRLKAFNESAAAGEVQGIERRLMEETLADFVQAGADLPDEKRARLAALQSELAQVTQKYSENVLDATNAWELIVEDEARLAGLPEHAKEAARQSAAGAGRSTGWRFTLHQPSQEPVMVYAQDESLRRELWEAAVAVGTREPHDNTALVRQILTLRAEKAALLGKPNFAEVVLERRMAQGGARALAFVEDLGARAAAAFAQDTSELEKFKAAQTSEPVAKLAPWDLAFWAEKLRQKKHAFDEEALRPYFALGSVVEGLFELVRRVFGVVVKERAAGAAEVWHPEVRFYDLFDADSGEQLGSFYSDWHPRDAKRGGAWMNYLRTGARSADMRTPHLGLICGNLTPPVGERPALLTHREVETVFHEFGHLLHHLLGEIAVKSLNGVNVAWDFVELPSQIMENWCWEREALDLFARHYETGERIPDALFEAMSAARNFRSATFLMRQVSLAKLDLLLHTDSARYLAASDIETAIRAAIAPHLVPTEPSAPTVLTRFGHIFSDPVGYAAGYYSYQWAAVLDADAFTRFKREGLFNRQTGRAFREAILSRGNAAPPMELYREFMGREPDLQAHLARSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF3</accession>
    <name>A0A139SNF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_04055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711488.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04055"/>
    <dbReference type="EnsemblBacteria" id="KXU36097">
        <property type="protein sequence ID" value="KXU36097"/>
        <property type="gene ID" value="AXK12_04055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="35811" checksum="835F01B27D0F40C4" modified="2016-05-11" version="1">MKVLVIGGAGYIGSHCVRQLVAAGHSPVVLDNLVYGHREDVAPDLPFYNADLGDEATVTRILHDEQIELVMHFAAFAYVGESVTDPLKYYFNNVVATLHLLRAMLNAGVKKFVFSSTCATYGIPEKMPITEATPQSPINPYGQTKLDIENALKALAHAHGLSFASFRYFNAAGAAEDGSIGEKHDPETHLIPLAFDAASGRRPALQVFGDDYDTPDGTCLRDYVHVDDLSRAHIAVFPKLTEPGTALFYNLGTGTPSSVIEVIRAIEKISGRPVPHTFAPRRAGDPPALYADSSKAKTELGWTPKFTSIEPIVETAWKWYAKNVLGEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG3</accession>
    <name>A0A139SNG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711684.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04530"/>
    <dbReference type="EnsemblBacteria" id="KXU36107">
        <property type="protein sequence ID" value="KXU36107"/>
        <property type="gene ID" value="AXK12_04530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="153" mass="16529" checksum="E48030F8AB87250F" modified="2016-05-11" version="1">MIIADIAKIPGNTFPARRWGRGLAGQSGQPIPAKGFTMGYVILEPNGGQVPWHNQEQEEVYMVLQGRGEICVGEEKSEITAGQMVYLPATVFHQLTNVGDSPLHMMYCYCPGGDVAHWRQELEGTLPRAGEGDIPALPAGAQPQCTDKAQAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG8</accession>
    <name>A0A139SNG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36032">
        <property type="protein sequence ID" value="KXU36032"/>
        <property type="gene ID" value="AXK12_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8677" checksum="F47D81B2145241A1" modified="2016-05-11" version="1">MQLIKNFISILLQENTGLRLKYLSPMLRKRLMACRSTKTEQLAIFIEQKAAAPIFWILSMTNMPILNNIFSYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNK6</accession>
    <name>A0A139SNK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711619.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04440"/>
    <dbReference type="EnsemblBacteria" id="KXU36072">
        <property type="protein sequence ID" value="KXU36072"/>
        <property type="gene ID" value="AXK12_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="127"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="402" mass="45308" checksum="16418E49AA292836" modified="2016-05-11" version="1">MKKLRTPMLILLCLASLLGLTASTALLYYWVHPIFGAAPQGARLDRITASPNYANGAFQNQIETPMLTANESRLSLMWRGFATRKRPETRPPRPLPTIKTDLRALDPAQDLVIWLGHSSYYVQLDGRRILIDPIFNDHAAPFPWMNRSFAGTDLYTAADLPDIDLLVITHDHYDHLDYKTARALRSKASKVLTPLGVGAHLEAWGYPDYRVNEIDWGDVFRVGAIGSNRASRRDGSAQSGNRAEKPALEIIATPGRHFSGRTFKRSQTLWMGLILRTPTRRLFFSGDTGYGPHFAQIGAQYGPFDWVTLDTGQYNPRWAFMHMQPEEAAQAAEALRAHAYTPGHVGRFTISDHDWDEPFKRASAASAGRSYALWTPEIGRPVYLDGRPQHFAPWWEEEENGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM1</accession>
    <name>A0A139SNM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36092">
        <property type="protein sequence ID" value="KXU36092"/>
        <property type="gene ID" value="AXK12_04550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="118" mass="12441" checksum="F9868F96CC3FB749" modified="2016-05-11" version="1">MGAEFAAVPGTELKALRVSGQTVPDAPYSFSGLQNGLNTLLLEVDYGPEPGSNNQSSGTVTGNLRIYEQPYSMVIGTVYTQDSGTLMDADDLNVHEVEDVRGLETTSAVIDALTITAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP4</accession>
    <name>A0A139SNP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711421.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03900"/>
    <dbReference type="EnsemblBacteria" id="KXU36205">
        <property type="protein sequence ID" value="KXU36205"/>
        <property type="gene ID" value="AXK12_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="338" mass="35645" checksum="DEA557B1EBF24F88" modified="2016-05-11" version="1">MDSPQPKSKKRPRPQLTLGATLALGLLISAFSGALDPYFLDVLTSMGIAVILAVSLNLVTGFTGQFSLGHAGFMSVGAYISAGITTALFAGNPLGNSAFAQSGFFLGSLLLGGLGAAFAGLCVGIPSLRLKGDYLALVTLGFGEIIRVVFQNIEPIGGALGLNGIPPYTSVFWVITWAALTVFVIHSLVHSTYGRGFVATHDDEIAAEAIGLDTTRYKIVAFVVGAFFAGVAGGLYAHFRLSIVPTGFDFTKSIEIVLMVILGGMGNTIGVILAAVLLTLLPEVLRPIAAYRMVLYSLLLIVLMVSRPRGLFNLNWAALLLHLKKRTTETLTKRGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNQ1</accession>
    <name>A0A139SNQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP cyclohydrolase FolE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711466.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04015"/>
    <dbReference type="EnsemblBacteria" id="KXU36188">
        <property type="protein sequence ID" value="KXU36188"/>
        <property type="gene ID" value="AXK12_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="324" mass="36806" checksum="B244EA3D06F1811F" modified="2016-05-11" version="1">MGKHMYLHRTAEGQPPKFERAYDAAFRASPSYRASLPDVMEAEHAPLRGEHRPQQQVGIHNFRLPLCYRTATGEQLTLETSVTGTVSVEAEEKGINMSRIIRQFYAHKDEPVNCESIGRVLRSYLSKIESKEARLRLSFSYPMLLKSLRSEMEGYQYYQSAFEGVMTDAGEYRRFVHFDFVYSSACPCAAELTEHARDTRRAYGVPHSQRSKARLTVELAKGKKLALEDLHAHCVRALQTETQVMVKREDEQAFAELNGAYLKFVEDAARLLYVELDADRRIADFRVSCAHLESLHSHDAVSTIAKGVPGGLRTDFMDYGQLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNR0</accession>
    <name>A0A139SNR0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03820"/>
    <dbReference type="EnsemblBacteria" id="KXU36196">
        <property type="protein sequence ID" value="KXU36196"/>
        <property type="gene ID" value="AXK12_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="327" mass="37092" checksum="6C143F2C06E7D85D" modified="2016-05-11" version="1">MSKVLSGPLPMNTPLVTPLDPSLRLEQHDDTALSLHFGDLELFRYVYRSDAYPEEAPRPYFHPLRSLEGDVMTNFRPNNHPWHHGLSLTMNNVSGANFWGGPSYHEDGYQWRGDWGRQSHVEWRVQEASGNRARLEEVLEWTHHDEVIFREERRIGIAVNSPEKVWTLRWRSTLTNASSHDLTLSNPGTYGLEGMHYGGLTFRGTRDFFDSYLDSTLKITAGNFGDPDGVNAPFKGGEQANGACADWVEFRGQFDGSLRHLHIRFANHTGPLRWFVLPKMEMVCFSPHATSSLDLPRGEALELDHSLSFACAPGSLRVRSFVDQNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS8</accession>
    <name>A0A139SNS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03725"/>
    <dbReference type="EnsemblBacteria" id="KXU36253">
        <property type="protein sequence ID" value="KXU36253"/>
        <property type="gene ID" value="AXK12_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="247" mass="27242" checksum="AB5010127B96F100" modified="2016-05-11" version="1">MKTPEAFVEGMKTLADIGFKSVQLSGVDFDMMSEADFVRVCGEVGISITATHLIGTGDLDEPQRCIDRLGKLGVTQDAYAYPAGVDFTDEAAVDRWLAKLEAANQAYKKAGITLSYHNHHLEFMRSRGKSIQQRIFDETTLAFEIDTYWIQAGGESPLAWVQRCAEAGRLPLIHLKDFRIGVDAQSKSPVAQFAEIGSGGIDFKPIIAAAEAGGCLSYIIEQDNSYGRDEFEAAAESFRYLRDHFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNW0</accession>
    <name>A0A139SNW0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03885"/>
    <dbReference type="EnsemblBacteria" id="KXU36202">
        <property type="protein sequence ID" value="KXU36202"/>
        <property type="gene ID" value="AXK12_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="30548" checksum="E81440AE38198995" modified="2016-05-11" version="1">MSLVGRFTSARLMSASLVTRVETLTDICQNAQPAAMDERKPAVSGKKGPRPRAKKLAVLATFGVGALVVAAWGLKHYGSELGAWWALGLEQVRGAGPLTFFALMVVLPAFGCPLSVFTLTVGPVFGPLLGIVAVLALTLLSVALNLAFSYWLASRALRPVLARLVAWLGYTLPKARAQDCGSLVFLVRVTPGPPFFLQSYLLGIAHIPFRIYFVISWLISGAYACAFVLFGDAVVHGHGKRVMLAVGIFAVLTVGVQWLRRRYRNPREGAGGVTVANAQEKEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNW2</accession>
    <name>A0A139SNW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711366.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03750"/>
    <dbReference type="EnsemblBacteria" id="KXU36258">
        <property type="protein sequence ID" value="KXU36258"/>
        <property type="gene ID" value="AXK12_03750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="339" mass="37172" checksum="FBF7468D2B89E2BC" modified="2016-05-11" version="1">MIAQRGTRPSPPNAGSNATALAPLVDIVERATRGVEELSTPIPGLRLFRRNSITQPSYCFIKPSLVLVLQGVKQMVVGTATYVYDTSRFLLTSLEMPARSEVLAASPDAPCLGLNFQLDLHTITELLATGSLPDPRHAAHAQDEKNKDARPASLTQNKELEELRSMGIGEVTPALLDAVSRLLALLDEPAAIPTLAPLIQREIHYRLLTGAATAARLRKITSIDSQAHKIAKAIDWLSENYAAPLSIDALAARVQMSPSSFHQHFRALVAMSPLQYQKRLRLNEARRLMLNEQLDAATAAFEVGYESPSQFSREYARHFGAPPKRDIATLRKHSTSQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPL0</accession>
    <name>A0A139SPL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711224.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03240"/>
    <dbReference type="EnsemblBacteria" id="KXU36473">
        <property type="protein sequence ID" value="KXU36473"/>
        <property type="gene ID" value="AXK12_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="449" mass="49083" checksum="E13A29B66700EEB9" modified="2016-05-11" version="1">MSLTATPEFAAHALTPPVDLLRFNTCGSVDDGKSTLIGRLLYDSKSLMEDQLEALERSADLTGGGQINLANLTDGLRAEREQGITIDVAYRYFATPRRKFIIADTPGHTQYTRNMVTGASTANLSIVLVDARSGVIEQSRRHTAIASLLRIPHLVVAINKMDLVGWSQERFEEIRADFEKFLPRLDIQDVKFIPISALSGDNVVSLSDKTPWYTGPSLLGHLETVHIASDRNLQGLRLPVQWVNRPNRPDDPALHDFRGVSGQLAGGLVRRGQQVVVLPSGITTRVRAIHTHDGELEEAFCPQSVTLLLEHDIDISRGQMIVGLEDLPGAGTELAAKICWMHPRALTAGRKLLLKHTSLTTQAIVSAITHRIDITSLEPGEAPDGLGLNDLGEIRLRTATPLVYDGYKTNRQTGAFILIDPATHATLAAGMLLPPKAIVRPDEDGDWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPX1</accession>
    <name>A0A139SPX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36616">
        <property type="protein sequence ID" value="KXU36616"/>
        <property type="gene ID" value="AXK12_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028963">
        <property type="entry name" value="Imm9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15587">
        <property type="entry name" value="Imm9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="325" mass="37087" checksum="5D65A24BCC944BB0" modified="2016-05-11" version="1">MAIKVPKLGKFANINSISRKLNTYLESIPPRINIEDLSGGRLIFRINSFCTDRIAIYKNLDYDFAHREFVISIAIPLPDNTQVPYGMPPGENGKTGSFPPVESEHFYPLDPEYDNYDNLEQYILEAAIKAIEYGLTKGFTDGGIELKFSSSIETRRLPSPQRKYVMEYKKVTVVMGNNVPRLDDFADMSSIYKKIDTYIKSILPRINIKDLSEWKLTVGIDHVCAECISILKKLGPYPSHKEYVTLLAIPIPDDRQAPYGMPRSEDEPIEPLELKRKSDFHLLDPEYDKYADLNQYILASTIKAIELGFTKGFAREGKALRFQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ18</accession>
    <name>A0A139SQ18_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">AXK12_02810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711141.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02810"/>
    <dbReference type="EnsemblBacteria" id="KXU36705">
        <property type="protein sequence ID" value="KXU36705"/>
        <property type="gene ID" value="AXK12_02810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="270" mass="27911" checksum="42169DC8AE34E829" modified="2016-05-11" version="1">MTGRILTLDLGNSTLAVGVFESDRLVKHLRLPSDASAQQLIRRVGKSFSTVALSSVVPERTAPLFTALETAVGLRPLLLSAAANHGLKIGYRRPAQLGTDRIAAALGARKLYPSQNLVIIDCGTATTLSFLTRESELLGGAILPGLALWPAALAHATAKLPSVKLPRAQGSLPPLVAKDTVSAIRAGALYGHAGAIRELAARGAHDAFGAHAAALALDAPRRGPAQTRQSVTVIGTGGQAPHFAAQSCFTVTEPALTLHGLQAYAAAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ38</accession>
    <name>A0A139SQ38_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711145.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02840"/>
    <dbReference type="EnsemblBacteria" id="KXU36709">
        <property type="protein sequence ID" value="KXU36709"/>
        <property type="gene ID" value="AXK12_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="394" mass="44903" checksum="445BCEDCB239A08B" modified="2016-05-11" version="1">MIARYLPAALRRLFKITVPSRPPAYTLIDQPGQLAPLLTALSRVSELALDTEADNMYHYKTRVCLLQFLVGKEVFMVDAQAPLLKLDALWEALADKHLIMHGSDFDLRLLYDLCRFSPRSIFDTMLAAQLLNRPRVGLASLLEAHFQVKLSKDSQKANWSKRPLTQKMLDYAALDVWHLPALRDILTRELERRGRLPWLKQQCEAQIKAGLSGFAPRDENAWRIGKSEKLKARGLSVLHAVWHWREETAERLDVPAFKVCNADRLLTLAQAADAGDSLAAILARVHLGRRHERLLPTLTAAVTLGLERDPQTIEVRRKRRRDPDAQPLTQAEVELQQKIREDRDRLAQKLSLEPTLIANRTQLARIAREPRALDEILLPWQAELIRSMPALQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQE9</accession>
    <name>A0A139SQE9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02800"/>
    <dbReference type="EnsemblBacteria" id="KXU36752">
        <property type="protein sequence ID" value="KXU36752"/>
        <property type="gene ID" value="AXK12_02800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="329" mass="36555" checksum="34C59DF84FE942DD" modified="2016-05-11" version="1">MHVECDPKGRRWNYETCLEIAPLTLEINALKRERNAIILTHSYVEPEIVYGVGDYKGDSYFLSLKAKEAQADVILFAGVVFMAETAKILSPQATVLVPDRGSGCSLADSITGEDVRRLKALYPDAATVCYINSTAEVKAECDVCVTSGNVYSIVAALPQERILFVPDRLMADNIRNELVRRGVKKEIISSDGTCMVHEEFDVAQIEQARAQFPGLKVVSHPECTEAVARASDFVGSTGEMMRYVTSTAAPYFLMLTECGLVGRLEVESPEKNFIGGCRLCPYMKLNSLEKIRDLLRAPRPEQIVTLDEDLRRRAARCIDRMFELTPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQK0</accession>
    <name>A0A139SQK0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ORF">AXK12_02960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711165.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02960"/>
    <dbReference type="EnsemblBacteria" id="KXU36731">
        <property type="protein sequence ID" value="KXU36731"/>
        <property type="gene ID" value="AXK12_02960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="475" mass="53233" checksum="141B4FA95A5B8168" modified="2016-05-11" version="1">MKKAPFIHDDFLLHTDAARDLYHNFAKNEPIYDYHCHIPQRLILENHQFEDIAEIWLGGDHYKWRAMRANGVDERFITGAASPREKFAAWCATVPHTLRNPLYHWSHLELARYFGITELINSESADRIWDAANERLAGLRVHDILAANKVAVVCTTDDPACSLEAHAEINRSAAIKTRVYPTFRPDNALIVDRPVAFNAWCEKLGGAAGIPVNSFDDFLTALDRRHAAFHEVGGRLSDHGMEAAFAAPCTPAEAAAIFKNARAGRAATLEECAKFSAYLMLEFGRWDARRGWAKQLHLGALRNNNRRLLAALGPDTGFDSIGDLPQASALSRYLDSLDATGELPRTVIYNLNPAENYVFGAMIGNFQDGSIPGKIQLGSGWWFLDQKEAMEWQINALSNLGLLSRFVGMLTDSRSFLSYPRHEYFRRTLCGLLGADMARGELPDDRELVGGMVRNICFANARDYFRLELEPSYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQU5</accession>
    <name>A0A139SQU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_02515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000017">
        <property type="protein sequence ID" value="KXU36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711087.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02515"/>
    <dbReference type="EnsemblBacteria" id="KXU36979">
        <property type="protein sequence ID" value="KXU36979"/>
        <property type="gene ID" value="AXK12_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="39"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="588" mass="63762" checksum="C744523C12BA11FD" modified="2016-05-11" version="1">MRRFRPYLHYLRPARAQLALALAALCLYSAANGFGLPYLLPTVFGPIFDSEERSMELAQVARLALLVPALFLVRGIAGYLSAYLFQSIGTRILEAIRVDFFRKLQHLPLATLQRYPKGDLTSRAISDAQQVQATITSIASEGIKHPLSLIGALSYVVYAAITTEGLTLALVCMAIVPLSVFPVRYVGLKVLRRARQAQVQIGSISSLLTENLGAAREVRAFSLEAHATTRFAQASRLLLTAQMKIVKYSLALTPTIEVLSALGIAITLVFAYRTGITFSSLMGVLTALYLCYEPVKKLGALNADLSRGAAALDRLEPILREPLTLTDPAEPRTLPASPRGEITFDQVSFAYTPDARCPTLDRVSIKIPAGTTCALVGPSGGGKTTFVNLILRLHDIASGTIAIDGVDIRQLRLAELRRHIAIVSQEPVLFNDSIYNNLLLGRPDATRDEVLAAARAAHADEFIKTLPQGYDTPVGEHGALISGGQKQRIAIARAFLRDAPILILDEATSALDAQSEQAIQNALQHLVIGKTVLIIAHRFSTIRDASTILVLDQGRLVASGPHAELYANTPLYRSLYDRQTTLGNDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQY8</accession>
    <name>A0A139SQY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02450"/>
    <dbReference type="EnsemblBacteria" id="KXU37025">
        <property type="protein sequence ID" value="KXU37025"/>
        <property type="gene ID" value="AXK12_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plug" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="756" mass="81729" checksum="71C86D18A034CAD5" modified="2016-05-11" version="1">MGFAQEAPQATAAAANDADIVTLSVFEVSSSAPARYQAAESAAGGRINTSIMDTPTTVTVLTSDFLSDVGGTRVLEAAKYVAGVSEATIPNALDRVIIRGFQTDGRRVDGFHTGGQANYDHGAIERVEVVKGPDAVLHPAGAPGGTINLVTKKPQWTPGGSLKLQVGEYDVNRVEADVTGPINDHFAYRMVAALQDNEGYIDGAFRESTLLTPSLTWKISPQAQLTLRYEYYYFKAANIVGIPTDPSVGTRDPFKVMQGVPHNFNPTFGKDYEFRRTTAHTGTLLFTSAVTDRLSVRLAGRLTEMYTPDSDLRIRLKSPGGSRNPFTGEWEGGVDWVNTSSDPANPNFVATPAAPVSPIIGLTGWQGNFGDRYRDVQNDWSYIVDGTAAKSTTLVGFSYSYFHNTGQGYNRISPDIDITKETRPSGPSIITPSVRDQRTNTSRYQVYLTEQLELFEGRLMLNGGVAHLTFNGMYHDKHEPAAPPPNPVLPGQAFAGEGSKATYNYGLVVKPIRNVSLYYGHTENAVPIGPNDYRRANQGEVPLFSAGTQDEVGIKANFLDGRIIASVAYYEIEQTGYALHNPGNFATPQPPQPLPAIISTRNGSGWEFQLAGSVTEALSVMASFADTKNRNPDGIMLNSSAEDLGALFVRYELNKGRLGGLALAVGVNYQGKRAAGDTAGYTDASTPDNLIPNQPSAYMPARTLVDVTLSYSRKNWSYGLTLANALDKTYYAAADSRDLINVGTPRNLSGTITWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR42</accession>
    <name>A0A139SR42_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ORF">AXK12_02595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711100.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02595"/>
    <dbReference type="EnsemblBacteria" id="KXU36921">
        <property type="protein sequence ID" value="KXU36921"/>
        <property type="gene ID" value="AXK12_02595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="77"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="423" mass="46129" checksum="FD317A04AF3A3136" modified="2016-05-11" version="1">MSSAAAVSSSDSSRSPSAELLNRFSQPDAGGHFGEYGGVYVPETLMTALQELEATYLAAREEPEFQAELAHHLAEFAGRPTELYYASRLTEHCGGAKIYFKREDLLHTGAHKINNALGQALLARRMGKQRIIAETGAGQHGTATAAVCAKFGLECVIYMGAHDMERQALNVFRMRLMGAEVRGVEAGQKTLKEAVNEAMRDWVTNVRNTHYILGTAYGSHPYPMMVRDFHRVIGREAREQVLAREGRLPDELVACVGGGSNAIGLFFDFLEDPQIAMIGVEAGGLGIRRGEHAARFASGRLGVLQGCKTYLLQDEEGQIEGTHSVSAGLDYAAVGPEHAFYRERGRIQFTYATDDEVLDAFQLCSRLEGIIPALESSHALAHGIKRARELGPDKLLVINLSGRGDKDVEQVAAILRERADRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR50</accession>
    <name>A0A139SR50_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711060.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02370"/>
    <dbReference type="EnsemblBacteria" id="KXU37012">
        <property type="protein sequence ID" value="KXU37012"/>
        <property type="gene ID" value="AXK12_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="252" mass="26951" checksum="56F6B09B73380ACB" modified="2016-05-11" version="1">MPPLLQRKGILLAGGKGTRLHPLTLNTSKHLLPVGDRLMIHYPLATLIAAGIREILLISTPQHLPAFEQLLGDGGPLGAHLHYAAQPRPEGIAQAFAIAAQAGFLSDSEASVLALGDNLFHGGPELADTLANAAARADGATIFAHPVPNPSDYAVVEFSPEGHPLSLEEKPASPKSSYAVPGLYFYDHRARALAATLKPSARGELEITDLNRRYLALGDLHVEKLPAGTTWRDLGTHANIHELHLWNSARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR62</accession>
    <name>A0A139SR62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="13" type="ORF">AXK12_02315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711049.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02315"/>
    <dbReference type="EnsemblBacteria" id="KXU37095">
        <property type="protein sequence ID" value="KXU37095"/>
        <property type="gene ID" value="AXK12_02315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="324" mass="35760" checksum="7A05F574B7CB1839" modified="2016-05-11" version="1">MESSAYVLDFEKPLRELALQLDALQQQSLETKLDLKQEIAAIEKKIEQTQREIYSNLSPWQRVQIARHPKRPYALDYVTQLCEDFVELHGDRQFRDDRALIGGTAFFNGQAVMIIAQQKGRDTKEKIARNFGMPQPEGYRKANRLMKMAEKFGLPILSFIDTPGAYPGIGSEERHVSEAIAVNLRDMALLRVPSIAVVVGEGGSGGALGIGVTDRVLTFENSYYSVISPEGCAAILWKDGSAAAQAAEALRLNAATLESLGVVEEVIPEPSGGAHYDASAAAKSLGKVLEKHLRQLRKLSTDELLEARYARYRKLGVFEEPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRD8</accession>
    <name>A0A139SRD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711046.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37092">
        <property type="protein sequence ID" value="KXU37092"/>
        <property type="gene ID" value="AXK12_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="108" mass="11799" checksum="3FC72283AB7308A5" modified="2016-05-11" version="1">MTAPIRTHASDATPTSGAPRKKILSLLRLLSAFCLVFGIVYWSGKGAHTGWSMNRVPVTQVDEITGIEFITYEDRFVPGIEWLGGAVGLAAVAFGLSFFFRTKKTHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRH4</accession>
    <name>A0A139SRH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711034.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02225"/>
    <dbReference type="EnsemblBacteria" id="KXU37080">
        <property type="protein sequence ID" value="KXU37080"/>
        <property type="gene ID" value="AXK12_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="304" mass="33571" checksum="3776AB259DE2ECE6" modified="2016-05-11" version="1">MELYQLRSLIAVAEGGNFTRAAESLGLTQPALSQQIINLEKELEHKLLHRLGRRAVLTDAGRVFIERARRILLEADNATKEIRDHAQTESRITVGAIPSVAPYILPALIAQARLDYPQLQIRAREDFRPELLDAVLDGSLDLAIVSTPVANPALAVEPLMREPLLLAVGPEHPLLKKAKIKAADLAEETFIMLGTSSSLAERVRQFCGDHKFEPRIGYRCSQLATVKSLVALGAGIAILPRIARSSKDDGQIVYLNLADTQPTRELVVVRHLQSYQARGILQFLKMLREGLGAAHSIARKPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRH9</accession>
    <name>A0A139SRH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000014">
        <property type="protein sequence ID" value="KXU37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37114">
        <property type="protein sequence ID" value="KXU37114"/>
        <property type="gene ID" value="AXK12_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299406" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1241" mass="130369" checksum="DF6F16FF756E42AB" modified="2016-05-11" version="1">MAFACASGFVFGLFGVSTVTAQILPPSGVTTYHWDRGAGTNNWEDGANWYNSTSAFDNQVPVSNADLVFGNKPSGTDAQTVILPAGDTAVRSIWFEAGRDYTLQGFGGTFILGAGLEDGGRLVTVLDGGLPANRYTIGQRISLAPADAGNPAKTFEIANYSTDSVLSFLGSINLRGHSLRVTGTGVTYFRESITLSNGSVLSTVASSTTDPTILMIGNIILPGLAATAQFTVGSNTLVIRDGFSSTSVGISTTVQSGGSISMRSGDHLMGTTFLSGLGLVRQAGAAPIGALYADGPTDISTQNSAVITLVADTAFGARSGRSDGLIIRQRIVGAGSSGFTKLGSGLIYLPSSAKQGTQGNQASQWTGATAINGGVLRVGLETNDWWAGLSLASTPLQFNGGILEFRAPDSDPTPPFGMTLGTGAGQVQWLGDGGFSSAAVSDTVTLNGGNSLTWGSGFFVPTGSKLLLSSRYATGEITFTNEIDLGSQLREVRVERGVRSTDAQGNPVENARARMTGALSGTGGGILKTGLGLLWLSSSQNSYSGPTVIREGALRGNIPISSNIELDGGVLALDTNFTRSRFGPNGRIIWQGSGGFAAYGFDRLVQIDNETTSEIVWGSNSFVQAGQELRFGHYTADAAVIWDRVLNFGDAMRTIRVERGQALRGGAPNLTDVIFNRELRNSTKAGGLRLVGDGRAELTADNIALDSDVLEISGAELALVNSNARLGPVGNIALSEGGRFAIRNHGFGDSLGSYDSAQVADTTKVTFNTGTLRYDGRRNEGLLNIFWDLPSVETIGDVVLESGANEIRIHHNMPATGNASYTQLEIGEFKRASSSRATLDLTSNADVTGATASLYTYSATGKVRLSAAATTLSEHMIGGINPWATINGTDWASTDASNANYIANFANYTTGTQHTGNYMPGATVAETNFGIVTLNSLRLAAWSNGSATGSHRATLNGALTLSSGGILANGAVSGISTIAGTGTITTAASRPLYTHAYGNGLQFTGFTSVIGGIDWVKAGPSPLYYNGPTTSQIGSLYIHQGRFELNNGTLNTGANGQVYIGDGAGRDELRILGGTDRLSSRPKVTLRGTPYGRGAEFGAAEDQATLALVNGASQGLRELHIIDRGTIDFRNGTVASPNRLFLDLLTFNNSGAQLFVRGWHEYEDFLLIKKTAYDPDRWSDLLSQVFFDGYSLDYKLLLKDYNADYYEITPWGVFPEPSTYGALLAAAGIALVAWRKKRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRL7</accession>
    <name>A0A139SRL7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711023.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02170"/>
    <dbReference type="EnsemblBacteria" id="KXU37154">
        <property type="protein sequence ID" value="KXU37154"/>
        <property type="gene ID" value="AXK12_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="361" mass="38885" checksum="4A2873EB7B71C142" modified="2016-05-11" version="1">MNRASSAKSPLSVSQPATSFASVFTHLKPHLAALDTFLREQVAAFEPEIREMADYCIDTSGKRIRPALVFLSAWRDEGDAAAGGEGGGVDTVDSQLVRAAAVVELAHLATLVHDDIMDEAQLRRNRETASRKFGAVAAVLLGDAMFAHSLYLAAHFPTTEVCARVSESTRRVCAGEIVQTMRRGSVRVSREDYWRIIDLKTAELFRVSCFLGARLSGGSADYVEAAARFGRHLGIAYQIYDDLADFFGDEARIGKTLGTDFASGKLTLPLIVLAESLPEVERAELLGEICGERPGQMERRLAQMAERGVFENVAAEVEREIVLAERALTPWSGTGRAQLLGGLCGVLRAQVSGLAGAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS61</accession>
    <name>A0A139SS61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37383">
        <property type="protein sequence ID" value="KXU37383"/>
        <property type="gene ID" value="AXK12_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="16693" checksum="1ECE41C7053DD9D9" modified="2016-05-11" version="1">MIEVRLSLEVVVPLLEVVTEAAELLCEEPSSAVHLASLPDDLREVWRADLVGSQKSDIHQLLGLFGEKFFEEGLVYLDEQNAEPVLRACAAVRLQLHRRQLHGLSEDELESGEIEVANLTEPLRRAFVAYLFLATLQELILSHLNPIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS91</accession>
    <name>A0A139SS91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711003.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01995"/>
    <dbReference type="EnsemblBacteria" id="KXU37413">
        <property type="protein sequence ID" value="KXU37413"/>
        <property type="gene ID" value="AXK12_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="338"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="550" mass="59175" checksum="526075CA6B6519D9" modified="2016-05-11" version="1">MFFTAFFLWPILQILKGGFFDADGRFTTEYFAVLLSDPLYLGGLRNSFLLACAATSLSLLIALPLAFISDRFLFPAKGLFSSLILVPMILPPFVGAIGIKQIFGQYGAVNALIIALGLRPEGWAFDWFALNRFWGIALIEALSLYPIVYLNATAALANIDPAMEEAAENLGCTGLRRVFKITLPLIRPGLFAGGTIVFIWAFTELGTPLVFDYARVTPVQIYYGLRDIGGNPFPYALVAVMLGSSVALYGLGKGLFGRAAHAASPKATTLSAPRTLRPLPRTACTLLFAAVTFVAILPHLGVVLVAFSPDWYATVLPQHFTLENFALALGHELTVPAIANSLKFASLSTAIDIVLGVAIAYVVVRSRLAGRQILDFLAMMPLAVPGLVLAFGYLAMSQEGKAFAFLNPVENPTVLLVIAYSVRRLPYVVRSAVAGFQQTSETLEEAAQSLGSPPLKATVKITLPLIMANLIAGGLLAFSFAMLEVSDSLILAQKQLYYPITKAIMELFQLIGEGKFIASALGVWAMAFLGVTLVGMTRLLGKNLGALFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSE2</accession>
    <name>A0A139SSE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710926.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37519">
        <property type="protein sequence ID" value="KXU37519"/>
        <property type="gene ID" value="AXK12_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299414" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="64" mass="7251" checksum="0623B4B029739167" modified="2016-05-11" version="1">MLFPKTLLLLCLVPFFAVSCINVKMQPIEIHATVDVNVKIDRELDDFFGDLDKKSTTLRPDTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STC0</accession>
    <name>A0A139STC0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710849.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01280"/>
    <dbReference type="EnsemblBacteria" id="KXU37823">
        <property type="protein sequence ID" value="KXU37823"/>
        <property type="gene ID" value="AXK12_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="131" mass="13670" checksum="27BD4C2FFF65AFF5" modified="2016-05-11" version="1">MSKREKSERVATNGGTALGQNPFGALSAAELPEAKIPALQANPAPTKPKSRGRLEIRRLKAGRGGKTVTLVSGFSGIGAAEKDALCKTLHQACSCGGTVNENGEIEIQGDQRERIAALLREKGFQPVFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD7</accession>
    <name>A0A139STD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710872.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01205"/>
    <dbReference type="EnsemblBacteria" id="KXU37843">
        <property type="protein sequence ID" value="KXU37843"/>
        <property type="gene ID" value="AXK12_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="361" mass="38061" checksum="2715DF6457AB9238" modified="2016-05-11" version="1">MSARPVAAAKKPVSKSGKSVSAKPAATSTAERKSTARPVETASSPKRKADAAPSAEALAAASAPALSAKAALSTPSGTQEWRADSAYLEIPVFQIEPSPYQARRVFAPEALRELAESIQSEGLLQPIVVRRVEDAEAGASGVRYQLVAGERRWRAFQGLNLKAIPARVVEAGDASSAALGLIENLQRDGLNPIEEAHGFASLIRDFDLTQEAAADRVGRSRASVANTLRLLSLDEELQGYLAKGLLSTGHAKVLLGVADSAQRALLARRVIEEGLSVRATERLVQELEKTSSAAPRTGGRAAKRGGAARDAEAVAAIEQKLTSQLGARVAVLHTPKKGRIVIEYHGNEDLQRVLGKLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STG0</accession>
    <name>A0A139STG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ORF">AXK12_01175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710830.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01175"/>
    <dbReference type="EnsemblBacteria" id="KXU37804">
        <property type="protein sequence ID" value="KXU37804"/>
        <property type="gene ID" value="AXK12_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="466" mass="50117" checksum="219325D1100E74ED" modified="2016-05-11" version="1">MFESLTDKLGSALRNLRGVGRLTEANMADALKEVRTALLAADVHFKVARDFIDRVQSACIGQDVLKSVTPGQQIVKIIHDELSALLGEGTTALSDHRPLRLMMVGLHGSGKTTSTAKLGRLLKKRGYSPLLVACDIYRPAAIDQLEILAAQEGLGFYADRHSRDVSAIGKAALDAAKAGNHDALLFDTAGRLQIDTDLIEEIKLLRTRIQPDEVLLVADGALGQEAVNVARAFHDAVSLTGLILTKLDGDARGGAALSIKAITGVPIKFAGTGEKTDAFEPFHPDRLASRILGMGDVVSLVERAQETIDQKEAERMAEKLRKADFDLDDFLAQMQQLKKMGPMQGLLKMIPGMSGVALPDNADKQMSRTEAIIQSMTRQERQKPQILNGSRRQRIANGAGVKIVEVNQLLKQFQQMQKMMRMMKGGGSRKMMRQMQQAMQANGGMGGAGAAGASGGLGGLGGGFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP1</accession>
    <name>A0A139STP1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">AXK12_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710775.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00875"/>
    <dbReference type="EnsemblBacteria" id="KXU37946">
        <property type="protein sequence ID" value="KXU37946"/>
        <property type="gene ID" value="AXK12_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="94" mass="10492" checksum="D7FBB95D35A1FA53" modified="2016-05-11" version="1">MPEEIDIDRVAQLARIALTPEEKEKFSRQLGDVLTHIHQLEQVDVSGVEPMSHAQPLANVWQADEPRPGLPLEDVLRNAPAHRSGMISVPKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STP8</accession>
    <name>A0A139STP8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710798.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01005"/>
    <dbReference type="EnsemblBacteria" id="KXU37967">
        <property type="protein sequence ID" value="KXU37967"/>
        <property type="gene ID" value="AXK12_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="395" mass="42258" checksum="32EF7AFF691BCC60" modified="2016-05-11" version="1">MKRTTVNFPLCGSISFAAQILRFVFLATPLVVFSAVANGATLEELWQERTGSVVAVEFTLDEGAGGAGANAGAVGSTPIQAFGTVIDAQGTVIFSTAAIELQTPPSALRDFRLYLPGGDIDAPLPAHYLGYDAFTEWHFVRVDAPSDAARLTPVTRFRSFGAGANGGPARPRVAEEIWGIGLRKKDEGFAPYFLSSRVSLVAEVPEAYAFAAREVAGPGLPVFNAAGDFVGLGQSGFGQAALQFSQRDREGLPVVMLNPDETPAVLLAEEILQEFITRVPESPSARTIPWAGFEQLRVIDRANAERLGLVGRPALLVGDVLPNSPAAKAGMQPGDAIISLNSRALPAIRPQSRLARYLERDIARRAPGDTLFIEVVRDRADESRMLILTLENAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STT0</accession>
    <name>A0A139STT0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">AXK12_01020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710815.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01020"/>
    <dbReference type="EnsemblBacteria" id="KXU37983">
        <property type="protein sequence ID" value="KXU37983"/>
        <property type="gene ID" value="AXK12_01020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="134"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU37983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="403" mass="43697" checksum="E883D7E668E427F1" modified="2016-05-11" version="1">MATSFVFSSESVGEGHPDKVADFISDSILDACLSFDRTARVACETLVKSNTVTVAGEITLPKLQDKKTGKSKPIDAAFNVNDVIRGAIREIGYTHDDDVFHADTAFINNQLTAQSADIAQGVDARRAEGKKTAEQGAGDQGLIFGFASDDTKELMPAPVMFAHRLGRELTRIRKSGQVKWLRPDAKSQVSVRYVDGRVTEIVNVVISTQHSADVTHAEIEQFITKEVIQKVLPAELLTKKTEFLVNPTGKFVIGGPQGDSGLTGRKIIVDTYGGWGRHGGGAFSGKDPSKVDRSAAYMCRWVAKNVVAAGLAKQCELQVAYAIGHPKPVSVYVNTFGTGKVSDEKIAAAVDDIFSFKPADIVKQLDLLRPIYRETTQYGHFGKAGLPWEKTDKVAELKAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STU6</accession>
    <name>A0A139STU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37934">
        <property type="protein sequence ID" value="KXU37934"/>
        <property type="gene ID" value="AXK12_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="13623" checksum="89F8EF35B72A9AFE" modified="2016-05-11" version="1">MREEEGRLHGEIARLQLELRAVEKARVGLMRGCGGAAVGRLRAPRGYLPRRILAVVGKASEALPRAEIIEGLRAEGYEYTLAPEAITRELVALTRAGKLKRIGSDNAARYEAVSRVGLIRSCAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STZ6</accession>
    <name>A0A139STZ6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ORF">AXK12_00915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710782.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00915"/>
    <dbReference type="EnsemblBacteria" id="KXU37952">
        <property type="protein sequence ID" value="KXU37952"/>
        <property type="gene ID" value="AXK12_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="241" mass="26382" checksum="D068E36A21CAE82E" modified="2016-05-11" version="1">MIGQLEELHGVLLVDKPQAHTSHDVVARLRGKLHTRKIGHAGTLDPMATGLLIMLVGKATRISQYLISLDKEYTGSIELGKITDTQDAEGRVMETRPVPALSEAELRKAMAGFMGDQYQTPPMYSAIKIDGVPLYKKARAGAEVVREPRFIRVGAFDLTRFGLPQFDFRLRCSKGTYVRTIANDLGERIGCGGHLAALRRTASGQFSLDQALPLEAILELSRAEIKARLIPIHEAAPSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU12</accession>
    <name>A0A139SU12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">AXK12_00730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710750.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00730"/>
    <dbReference type="EnsemblBacteria" id="KXU38063">
        <property type="protein sequence ID" value="KXU38063"/>
        <property type="gene ID" value="AXK12_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="199" mass="21774" checksum="46726C54925A7C89" modified="2016-05-11" version="1">MKITSAEFLTSAPGLRGCPPPGPPEFAFIGRSNVGKSSLINLLVGRRDLAKVSQTPGKTQLINFFSINRAWLLVDLPGYGFAKVAKSARADFNEAVADYLEKREPATLRHTFALIDSRLPPQKLDIAFLGWLAADTASPYSLVFSKADKQSRSKTQENVQRFEREVIATLARPPTARFITSAVERSGRNEILAAISGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU64</accession>
    <name>A0A139SU64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">AXK12_01085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710812.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01085"/>
    <dbReference type="EnsemblBacteria" id="KXU37981">
        <property type="protein sequence ID" value="KXU37981"/>
        <property type="gene ID" value="AXK12_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="208" mass="22941" checksum="92AF158E6F0D75C4" modified="2016-05-11" version="1">MSYYVPIVLENTGRGERSMDIYSRLLKDRIIFIGTPINDQVANLVIAQMFFLQMEDPKRDIQLYINSPGGIVTGGMAIYDTMNFLQCDIATYCLGMAASMSTVLLSAGTKGKRYALPNSRVMMHQPSGGAGGQTADISIAAKEILRWKKTLNETLAKHTGKSVEQVEKDSDRDYYLDAYEARDYGLVDHVMEPTKDAAALNAPQSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU79</accession>
    <name>A0A139SU79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">AXK12_00750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00750"/>
    <dbReference type="EnsemblBacteria" id="KXU38074">
        <property type="protein sequence ID" value="KXU38074"/>
        <property type="gene ID" value="AXK12_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU38074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="15537" checksum="E219DF2974A44C77" modified="2016-05-11" version="1">MAALQFLFAWSMNTPQNLAVDLSYFFQTRDHPRDHYAFGEELIHGVIENADDLDASIKGLAHNWDFGRIARMDLTILRLAMYEMKFRKDIPPIVSINEAIDLSKQFSSGDSRRFINGILDRFKDQLGRDARKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUD8</accession>
    <name>A0A139SUD8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710757.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38071">
        <property type="protein sequence ID" value="KXU38071"/>
        <property type="gene ID" value="AXK12_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU38071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="302" mass="33235" checksum="AADB1FD552221C64" modified="2016-05-11" version="1">MPDYRLHVFKIAAEKLNFTSAARALHISQPAVTQHIKQLEEHYGQALFVRGAAGLSLTASGQVLYEHALRAEAVEAELEARLRADESALRGTLKLAASTTIAQYLLPRWLGAFAQTHSQVRLDLRMGNTEEVGAALSAGRVELGLIEGFYARRELKSQKFLEDEIVVVAAPSHPLAKKNRRLSLADLAAAPWVLREPGSGTREVVERALKRVRINPKKLHVVLETWSSETIKGLVETGVGLGFLSRLALRHEVETAALVELPVEGLEIRRALQILRSQGPPPNGLAGYFADFIFEMARDCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH9</accession>
    <name>A0A139SHH9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713322.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08330"/>
    <dbReference type="EnsemblBacteria" id="KXU34025">
        <property type="protein sequence ID" value="KXU34025"/>
        <property type="gene ID" value="AXK12_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003468">
        <property type="entry name" value="Cyt_c_oxidase_monohaem-su/FixO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02433">
        <property type="entry name" value="FixO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="212" mass="23427" checksum="0726CB627DB6B2F1" modified="2016-05-11" version="1">MKNSAVFFLGLFAVFALSWAGIVLGTQAQLGDLAPHFDEMEEKAFPLRQSGLATRGQQVFQDLGCIACHTQQVRRPDFGSDQARGWGDRQSVSRDYLYQARPLLGNQRSGPDLANYGARAEARELTEADMLVELYNGSDERPPHRFLFEVREILGEPSPKALHGVAPEGYELVPTERALNLVAYLFSLKQTYDFAEAQPYEGGEDAAEGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHN7</accession>
    <name>A0A139SHN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_08360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713334.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08360"/>
    <dbReference type="EnsemblBacteria" id="KXU34031">
        <property type="protein sequence ID" value="KXU34031"/>
        <property type="gene ID" value="AXK12_08360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="487" mass="54985" checksum="EA950538C80DD8A4" modified="2016-05-11" version="1">MAAAHAQAAATAPRNAILDEVAPAHLPRATLVESERSMGWVTDKICGIIEGKTPRWWWLLFIVSCCVASFTVAGITYLVATGVGVWGHANPVNWAWDIVNFVFWIGIGHAGTLISAILCLLRQKWRTSINRAAEAMTIFAVVCAAIFPVFHVGRVWFAWFLFPLPNYNDIWQNYRSPLEWDVFAVSTYGTVSVLFWYVGLIPDLAILRDRFFAAGNKLRASLYGFFAMGWRGSNRHWSNYEMAYLILAGISTPLVLSVHTIVSFDFAVSLLPGWHTTIFPPYFVAGAIFSGFGMVLTLMLPVRAVYGMQDLITQYHIDCMCKIVLATGTIVGYAYGMEFFIAWYGANPNEGFAFINRAFGHYAWAYWWMIGCNVITPQFFWFKAVRNNTTFVWVLSLFVNVGMWFERFVIIVTSLARDFLPSSWGYYSPSIVEIFTFFGTFGVFGVLFLLFMRFLPVMPMAEIKMVMPQADPHAGHDDHGHAAHAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHS0</accession>
    <name>A0A139SHS0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_08385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713342.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08385"/>
    <dbReference type="EnsemblBacteria" id="KXU34034">
        <property type="protein sequence ID" value="KXU34034"/>
        <property type="gene ID" value="AXK12_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="41"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="40686" checksum="25A77C07F59B83CE" modified="2016-05-11" version="1">MGKKTLIAAFAALLVVFAYLYFSRPSAYVAEARAGRAVKAVPGSITVQAEYEMQLRSDLGGRVLRSFIDKGQHVSEGDVLCELDTGDLRLEIERIENEYETAKRRLAVGSAVELQLATSAENLAEFERLNRAGRYADAELTKRRREHAQVEQRAALEKVNNEQTLATYENTLRQKQRQLEKMTLRAPFDGVVSQVYARAGDLIGGGASIASLISTSRTVEAKISEEDFADIRVGQKVSARFLPYGTTLYDGTVSKILPTADPTTQRYIVELEVDIPADRLVPGITGEVIIVVGERDAKALIPRRALFGSAVYVVREGRVELRPVTVGYVSLTTVEITKGLEAGDQVIVEALDQFREGQRVRPVLPGTEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHV1</accession>
    <name>A0A139SHV1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713120.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07730"/>
    <dbReference type="EnsemblBacteria" id="KXU34162">
        <property type="protein sequence ID" value="KXU34162"/>
        <property type="gene ID" value="AXK12_07730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="293" mass="33843" checksum="D54D493E14D1F239" modified="2016-05-11" version="1">MMYNNYEKNQELTEKGGREMEQAAYTLPPPSPTKGPAVKIHILTGERHWYQAAFCLWSFAAASGRAVAPVIFDDGSLKLEHIEALKRTFPKLTFVGATQSLDWLDTHLPDSHYPTLRAQHRVNPIYRKLLDIHAGQVEWRLQMDSDILFFRSPEFVLKWYDLPQAQLYLYDIKNAYSASIDYLSELAGRPVLQRVNAGLLGIRSADIDWEQMEFWAKKLTAHGGSAHHVEQTLFALHLSDRECIYPDPKDYVLLPDPPEAIECKAVMHHYVTYARLWHFQKNWRRFVSGSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHX8</accession>
    <name>A0A139SHX8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="11" type="ORF">AXK12_07810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713144.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07810"/>
    <dbReference type="EnsemblBacteria" id="KXU34175">
        <property type="protein sequence ID" value="KXU34175"/>
        <property type="gene ID" value="AXK12_07810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="849" mass="92121" checksum="BD31179782A7A116" modified="2016-05-11" version="1">MLKRNLWKLSLSTLIVLWAVASLLPLQDQPFPDYIKSKASAERAEFTRLVDEAEARVAAGESPSVFVALKQLGKERKIDLAKHFPGIRFEGSLRNIERKNDILLNEMLRRSRSPLQLGLDLRGGVAFTLEVDEAAAASFGEHERREKLSKAIEILETRIDGLGVAEPIIRPVGDTRIEVQLPGVSTKDNPEVVDSVKKPARLDFRLVHPTASPQTSPVAPAGYERMALEQESPRGELLYEELYVKRLPEMTGAAIANAFARPDMYGKPEIILQFTSEGRSRFAEVTREIATLGRQTGIPGRLAIVLDGRLYSAPSVRDEIDSESAQITGSFSEREALNLANVLNNPLDLPLIIKEQYEVGPSLAADAITSAQKAFILSTALTAGFIIVFYTSGGLLAVIAMASNVLVILGVMASIGATLSMPGIAGVVLTIGMSVDSNILIFERMREEMKLGKSLPAALDAGFEKAFSAILDGNLTTLITAMIMVALGTGPVKGFGVTLAIGIFGTMFAALVISRFLLDWLINGVKIKSLKMFSILEGTRFDFLKYTRPAFILATSVVVIGAGAVVYKGKDVYGIDFTGGDQVVLAFGKKLELAQVRDVANRLGLEDINLSYTQAIGGDTEVLRVTTPFDQTAPLVEALQSAHPDAGLSPISETRIGPSVGAEIQRNALWAIFWSLLLILGYIAFRFEFGYGIGAVVSTVYDIVVTVGVFVLFGRQFNAAMVAAILLVAGYSINDTIVVFDRIREELRLNPGATLRDIINRSLNLTLSRTVITGGTTLITAIVLFVVTSGVVNDIAFTLLIGVLTGTFSSLFIASPVFYWWHKGDRKHVEKHHDIAPKYEWAGSSKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ2</accession>
    <name>A0A139SHZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07945"/>
    <dbReference type="EnsemblBacteria" id="KXU34195">
        <property type="protein sequence ID" value="KXU34195"/>
        <property type="gene ID" value="AXK12_07945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="368"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="743" mass="82425" checksum="4B3DB09ED37CB1F2" modified="2016-05-11" version="1">MSMLGLAASAYAQQAPDQSGDEIVRLSPFSVQESADMGRYQAAESTSGSRVRMDLMDSTQSISVLTNEFLSDIGTTQLLDAVKYVAGIGPSNGPDTMDIMSIRGFQNWELTTVDGFGQTSYINLDPVVVERIEIVKGPNAIIAPQGLPGGVVNSVTKRPLFKNSGSVSYQVGRYDANRAEIDANYVVKDDKLALRVVGAFTDSDRYMKEKYSQNFTVMPMLTYRISPSTELTAQVMAYNATSTLMSAPVSIYAVGRRNVHIMEGLPRDFALSNRDDNRHESSQRAHFFLTSQITDKLSMRLAGKWAQQSSRASEMNPSSPRDANGNLLDPQPIQVNPITGEWEWDGVIRSDTPRFTLAGAKDTTDRHHGNLQSDFVFEHLGQGWKSQTVAGYALSYRSSSGGYKNAFAAPLNGSTLFDLTDSSYIPASYIVDADWAANNSLRNRSHQVYLYQVLNLFDDRLVLSGSLSQNRFFSGRTDNLSGTSTDERAEATLPSAGIVYKLTPEVSLYYGYSEQEILGIAAPGDLIPAHTTPSRQHEGGLRLRLFDGRLYTTFSYFDIQQDGIWEGNPANWIDPLAPKQPAVTSNRTSKGFEFEFAWAPTKNISVIGSYTEFKSRDQSDRRYAHVAEKMAGIWGSYSFSETGSLRGLSFGIGASYVGERPADAGGQYTTPPQGFQPVRYQAMFWLPSYTEVEANATYRFNKHWRAQLVIKNLLDRDYIKAATNRTIYPSTPINPKLTIRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI26</accession>
    <name>A0A139SI26_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34199">
        <property type="protein sequence ID" value="KXU34199"/>
        <property type="gene ID" value="AXK12_07965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="231" mass="25464" checksum="45937F6259BB2064" modified="2016-05-11" version="1">MSLTGDQANTFTGDVIVEGRMNTLHLNKSDGVTSILGNIFVRKLASVNIVSSDQIADSSTVTLSERAILSFSAEPKAIREKIHALVVKEGTSRLSFYHSEGIRDNFKKTLILDDLLISDDGFLQISGWEAGRDHLLVRKDSEHLADAFKKITIDGWAKNQVYLKDYDKEYWSIEAAPEPSTYGAILGAVGLGLVIYRKHRHRMRSACGEKLGGAASPFKGSVALRGLRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI94</accession>
    <name>A0A139SI94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712993.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07410"/>
    <dbReference type="EnsemblBacteria" id="KXU34298">
        <property type="protein sequence ID" value="KXU34298"/>
        <property type="gene ID" value="AXK12_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="96"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="275" mass="30765" checksum="E12EFD3205791BF9" modified="2016-05-11" version="1">MPRIPIEDNFDDVINKTQRGLRISDEDLAARAEITADQLAAVKSGTPLYGVIRRVARHLNLSPDALEVLAKKAWYPEQPVLPRGFAMFNTAYEDMTVNAYLVWDTRTRQAAAFDTGSDCQAMLDVLRDERLDLHYVFLTHTHGDHIADLERLAAAAPRAEVWASEREPVEHPDARTFKENAQFHLGEIAIKTLYTWGHSPGQSSFYITGLSWPLAIVGDSIFSCSMGGSPSHFGNQLHHNKEKLMTLPKDTIIAPGHGPLTTVAQEKKYNPFFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC5</accession>
    <name>A0A139SIC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712991.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07400"/>
    <dbReference type="EnsemblBacteria" id="KXU34297">
        <property type="protein sequence ID" value="KXU34297"/>
        <property type="gene ID" value="AXK12_07400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="148"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="345" mass="37777" checksum="7B28DCD130063440" modified="2016-05-11" version="1">MKTAPKFKKASDIKVGVVGYGGAFSMGRLHLNSMKEAGMTPYAVAEPDKSRLAVAAEEFPGIETYASITEMLKKSAVNLVVLITPHNTHAPLALQCLRAGRHVISEKPLALTTKECDAMIAAAKKAGVMLSTYHNRHWDGCVLSALETLRSGAIGELVRVEARMGGWGKPGDWWRSSRSISGGILYDWGVHLLEYTLQLVDSEIVEVSGFAKNGFWAKQTKWKSDTNEDEAQAIVRYKSGVWSSLRMSSIDSSPKPGFLEITGTKGTILAEGDMKLIVKSESGTTTTQVKCPPNQWDKYYANISAHLAKGEPLIITPEWSRRPIHIIDLAIQSAKKGRSLTAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID8</accession>
    <name>A0A139SID8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712979.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07365"/>
    <dbReference type="EnsemblBacteria" id="KXU34291">
        <property type="protein sequence ID" value="KXU34291"/>
        <property type="gene ID" value="AXK12_07365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="175" mass="18796" checksum="ED2E2C0A4E590495" modified="2016-05-11" version="1">MSLKQPVWPRFLSTAAVLNCATLGPLGRRLPAPGTWGSLAGLLYFTVFFAGRYGVVGTFLLSAIGVYVAIGVCGEAEFRLGRRDPGEVILDEFVVMPLCFLGWPMLAHNVPNWMVFLAGFALFRLFDIIKPFGIKRLQSLPGGWGVVLDDVAAALATCATLHGLVALATGLGWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIE8</accession>
    <name>A0A139SIE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712999.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34301">
        <property type="protein sequence ID" value="KXU34301"/>
        <property type="gene ID" value="AXK12_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="32290" checksum="CB0E4594290259B9" modified="2016-05-11" version="1">MNTAPAPVFDDHEVDFHSPELYQPVGIGHGVERLEDVGPDEVDFFHREGYLVVRHAFDSDTVARAKAELIDLIMGKMPDFKGISFEAKARGILPMLSVDQRQDAVRKLQNFVNYAPVLHALAFHPALVRVMRQVLGGAAPKLIQDMALIKPPHIGREKPWHQDNAYFNYPVNALVVGVWIALDDATIENGCMRFLPGQHRDGPKVHFMRRDWQLCDTDTLGQRPLAAPLEPGGLLLFNGLLPHGTPHNSSGQRRRALQYHYTAEEIQPLPDDSERLKNFGSEGKNVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIH0</accession>
    <name>A0A139SIH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">AXK12_07630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713072.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07630"/>
    <dbReference type="EnsemblBacteria" id="KXU34336">
        <property type="protein sequence ID" value="KXU34336"/>
        <property type="gene ID" value="AXK12_07630"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="267" mass="28800" checksum="D2439C9917D7985D" modified="2016-05-11" version="1">MSDKLLEIMAHKRREIAPVLREVPLDELRELDASLPRPPSFAEALRRPDDDRLAVIAEIKRRSPSAGAIAENASATEQARRYQAAGASALSVLTDNKYFGGELGDLRDVVEMLRREPPSVPCLRKDFMLHPTQVREAREAGASAILIIVRALDDPTIATLYAAAQAAGLDALFEIHEEPELARALAHGAKIIGVNNRDLAVFKTDLAFSERLIPRFPKNVIAVSESGIATAADAARARAAGAHAILVGESLMRAPDPQALLQSLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIS2</accession>
    <name>A0A139SIS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712938.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00565"/>
    <dbReference type="EnsemblBacteria" id="KXU34436">
        <property type="protein sequence ID" value="KXU34436"/>
        <property type="gene ID" value="AXK12_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="30941" checksum="46885B3A5B27BE64" modified="2016-05-11" version="1">MKLFRHGLPGQEKPALIDPQGQARDLSGVIDDICAETLTPAGLQSLRAIDPQSLPLIATPGRIGVPFANPGKFICVGLNYADHAAEAGAEVPKEPILFTKWSRPTGANDPVVLPRQSLKTDWEVELGVIIGTQARYISREAALSHVAGYCVINDVSEREYQLERSGTWDKGKGCDTFGPIGPWLVTADEIPDPQNLDLWLEVNGKRFQNGNTRTMVFDVATLIHEISQFTTLYPGDIISTGTPPGVGMGQKPPVYLQPGDEMRLGIAGLGEQTQRVYAWDAALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIT1</accession>
    <name>A0A139SIT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34443">
        <property type="protein sequence ID" value="KXU34443"/>
        <property type="gene ID" value="AXK12_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="28469" checksum="3CBC876E18BB1408" modified="2016-05-11" version="1">MTTTDKNNRPSRRALVTGAAGGLGREVSRQLLERGCAVAICDIDAKGLADTEQLLLKQGGEVECIVCDLTTEDAPQAAVERAVARWGGLDVLVNNAGYGVIEPFLEATHKAWTRTLALNVTALAMLCKAAGRVMREQRSGRIINITSPGSRMALPDYTAYTASKAGVDSITRAAAVALAPYGVLVNSLAPGMMDTEMQRSTEMEMARINGRSDLQAFLDERTQRIPLGRRASVDEIAQAVVWLCLDAPPYMTAERLNMSGGLDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIZ0</accession>
    <name>A0A139SIZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712864.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07305"/>
    <dbReference type="EnsemblBacteria" id="KXU34548">
        <property type="protein sequence ID" value="KXU34548"/>
        <property type="gene ID" value="AXK12_07305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="343" mass="36976" checksum="BDE6F4B33A1CBDC6" modified="2016-05-11" version="1" fragment="single">MSFDPITIASVEVGTSKIAVILAEYSGDGFLIRGWGECRAQGMRKGVVVDYAACSQCTAQALEVAKQNAEAESIDRAFLALTGGHVQGFPSEASLAVSSPDNMVSAREVSQLRQLALAKELPEGRTLLQSLRRPFRLDGRMIRNSPEHLAGRRLELGYWLMHGDQHLISTAMHMVTSSNTPVVEMVPSSLCSGRVVTSRREREDGVLVLDIGAGTTDYVLYRYGAPYVAGVVAVGGDHLSSDLTTGLRLSVGQGDRVKLRHGRATVQCRDKAQRVWLDGDGAIGDRQLPLVSIERILELRVRELFEVVHQSLGEDFSPEHCAAGVVLTGGTSKLPGIADVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ00</accession>
    <name>A0A139SJ00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ORF">AXK12_07175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712819.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07175"/>
    <dbReference type="EnsemblBacteria" id="KXU34527">
        <property type="protein sequence ID" value="KXU34527"/>
        <property type="gene ID" value="AXK12_07175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="7"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="89"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="533" mass="57794" checksum="41BE1CB03479D71E" modified="2016-05-11" version="1">MTNTLRKPVLLVIRDGWGRNPYADQNPNNAAFLAATPCEDALRARYPVALVSASGLDVGLPDGQMGNSEVGHENIGAGRVVDQELVRLNKLFSEKQLAQNPVWRGILDRLRGSPTARLHLMGIFSDGGVHGMLEHLYGILEQAREDGISADRVLIHGFTDGRDTPPDSGLGFVAQVEARLREIGVGRIATICGRFWAMDRDNRWERVQRAYDLLAGRATEATARSAAEALERHYANPSAPSQVGDEFLPPTRILDEAGQPLPHFADGDAVLFYNYRGDRPREITKAFVLDEFDGFARGPKLDLSYATMTEYEAGLPVQVISGKPPPLKNILGEVVSRAGLAQFRCAETEKNPHVTFFFNNYRTEPFPGEDRYCPASPKVATYDLQPEMSAAEVTRASKEAILSGNYALIVVNYANPDMVGHTGSLEAAKRAVEATDAGVGELLAALEQVGGTALVTADHGNCEQMWDASRNMPHTAHTLNLVEVFVVAPQLNPQTPMREGGRLADIAPTLLALMGLPQPPEMTGQNLVAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ61</accession>
    <name>A0A139SJ61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_07215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712831.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07215"/>
    <dbReference type="EnsemblBacteria" id="KXU34534">
        <property type="protein sequence ID" value="KXU34534"/>
        <property type="gene ID" value="AXK12_07215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="675" mass="71728" checksum="079D948175A22FD4" modified="2016-05-11" version="1">MSLPTDTLAKAANQARGLAIDAVHKCSSGHLGLPLGAAEIGAALFGSALVHCPEQPRWRGRDRFVLSAGHGSMFLYAWLHLSGYEVSREDLAAFRQLHSKTPGHPEFRETPGVESTTGPLGQGIANAVGMAVAGKMAAARFNTPDHPLFDSSRVFCLAGDGCMQEGVALEAMEFAAHQQLDNLILIYDANDVTLDAMADKTQSLNAAARFKALGWDVQTIDGHDIEAIVKALKKARRAKSGKPQLVIAKTVIGKGIAEVEGTSKGHGEGGAKFAEAARARLGLPADEHFYVSEDVRAYFDAQKKRSARVANKWQRSYKAWRTANPALAAEIDTAAKAPSATQLLAAVPVFPADAKHGGTRAAGKDVLQPLAAQLPLLIGGSADLYGSTLNYIASSGDFEPATEANSAAVAGGRAGRNIRFGIREHAMAAIANGIAYDGLFRPSVATFLVFADYSRPAMRLAALTKLPVVYIYTHDSIGVGEDGPTHQPVETISALRLIPGFDVIRPGDAEEVVGAYAAALSREDGPTLIALSRQAVPLLNEIPAETRREGVLHGGYVAVRETTSLTHILIATGSELHLAVAAARELGSGVRVVSMPSMERFERQAPEYRESVLPSSCERRVAIEAGVTALWHRYVGPRGTIIGIDRFGISAPGPVIFKELGITAERVVEEVRALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJM5</accession>
    <name>A0A139SJM5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">AXK12_07075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712786.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07075"/>
    <dbReference type="EnsemblBacteria" id="KXU34700">
        <property type="protein sequence ID" value="KXU34700"/>
        <property type="gene ID" value="AXK12_07075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="204" mass="22332" checksum="D2574B29C4C84FAC" modified="2016-05-11" version="1">MPLSLVAGLGNPGRQYQDTRHNLGWVLVDAFAREKGLTWAYHSRFEAELASWQAADGRTVYFAKPLTYMNESGRAVAALARYYRLAPEQVAIVYDEYTIDLGRVKVSASGSAGGHNGIASVLQHLGAGFVRYRLGIGPKTTPQMDLKDFVLGKFSASQHSLLSDSLPHFLKGLDLLLNSGIEAAMNQLNRKDTTTTPPYDTDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJP3</accession>
    <name>A0A139SJP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="5" type="ORF">AXK12_06830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712690.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06830"/>
    <dbReference type="EnsemblBacteria" id="KXU34798">
        <property type="protein sequence ID" value="KXU34798"/>
        <property type="gene ID" value="AXK12_06830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="101" mass="11465" checksum="5EBD6AD5B2145905" modified="2016-05-11" version="1">MPKTSAIERNKKREALVEKYKAKRAELKAILANPESSDEDFFAAQKKLAKLPRNSSSVRVNNRCKLSGRPRAYIRKYGVSRIQFRELALSGKIPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJR9</accession>
    <name>A0A139SJR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712718.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06920"/>
    <dbReference type="EnsemblBacteria" id="KXU34812">
        <property type="protein sequence ID" value="KXU34812"/>
        <property type="gene ID" value="AXK12_06920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="188"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="280"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="465" mass="51288" checksum="4345B25F6354656D" modified="2016-05-11" version="1">MRNITHLKKGAWESAVHLLTRWLEQRERVDTLLVASPAGLTSVERARCQYSVYGVIRHFGRVQAALDELIAHSPRFPTRAILLLAGYELIEAAAAASASAQEMGDLQGRETVQGRETAADFTGQVAKIVHHAVEQAKRLTSPAEARLVNAVVRKLVPLMTAPPPPKLAGPELLARYFSHPEWLVRRWLFQFGAESTRRLLEWNQSTAKLSFRWRIQNTDSLPESSTPISGAAGFYEIESGHWAELEPLLKSGAAYVQDPSTRLAVEALELAAGERFLDLCAAPGGKSLLAADTAPKPGLARVVALDLPSPRIAFLKENLATIQGETQVALVQADLLTEARAALREHGLPLDYDAVLLDAPCSNTGVMRRRIDAKWRLQERDFRKHAQQQLSLLHAAARFVAPGGRLVYSTCSIDAQENEEVVRDFMQSRAGGSAFILEHSAMSFPWESGHDGAGVYRLRKRLTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ1</accession>
    <name>A0A139SJZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">AXK12_06605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712586.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06605"/>
    <dbReference type="EnsemblBacteria" id="KXU34898">
        <property type="protein sequence ID" value="KXU34898"/>
        <property type="gene ID" value="AXK12_06605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="280" mass="30774" checksum="CD369AF783F70191" modified="2016-05-11" version="1">MPAIAPPLRFLAYWTHDLSPFLLRFGEEGFGIRYYGLAYLLGFGVAAWLLYFYARRSDRSALPPALVADFMTALVVGVMVGGRLGYFLLYQPELLFSEPVALLRVWEGGMASHGGFVGVVLATWWFARRHGIAFLHLGDLVASVAAAGLFFGRVANFINGELWGKPSAVAWAVLFPESPLPLVPRHPSQLYAAALEGLVLLAFAQWRFWRSERVKTTPGRLGGEFLVAYALLRIVGEVFREPDASLILGLSRGTFYSLLTAAAGLGLIGFCHKTPLHKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK74</accession>
    <name>A0A139SK74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34887">
        <property type="protein sequence ID" value="KXU34887"/>
        <property type="gene ID" value="AXK12_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="331" mass="36452" checksum="714FCF8AFCF662BE" modified="2016-05-11" version="1">MAAAELRLSNGDRLTGTLIERSEGKLHFRSAVLGDLVIDESVATLVEEGPQSVAASESEASAAELAQAQAGVEIEAGAEAVAPLVADVEAGESDGTADSSGGVQVPPRVTWSGQIELALFSQTGRSKNQNSSVRLEASRVTKRNNYRLRSRYLYGKNADQVANDRINADLRWRRELGPRFFTQSLTSYLRDRVAQIAFNAEQNVSLGYQVFKDERHELNAGVGITGLYRDVTGLSQSSLYLGEVFQDYGYKLNHRFTISEGLNVLYSTDGRVVGTSVDNSHYKVRFNSALQGKMTERIALVLRFEYEYDNSILVKEARTDQRITTSVGYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE5</accession>
    <name>A0A139SKE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712400.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00300"/>
    <dbReference type="EnsemblBacteria" id="KXU35042">
        <property type="protein sequence ID" value="KXU35042"/>
        <property type="gene ID" value="AXK12_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="311" mass="36133" checksum="8DA6A63D260BF3F9" modified="2016-05-11" version="1">MSLPGKLLFQLWHRPYGYTRDLIKDGGPQQRRLTEKGRQEMEAAAYRLPAPPSGHGKPVELHFLTGRKYWYQTAFCLWSFAAASNRTLRPVLFDDGSLSEPYIEPLARLFPALRIVTAAESLARLDEFLPESRYPSLRGRRLAYPHLKKLLDLHVGQRGYRLQMDSDLLFFRSPDCLLDWHDNPEYPLRAEDIITSYGYPLGMLAELSGFPKVPERVNAGLLGLRSEDFDWDKMEYWCRELLARKGPSYYQEQALLAMLLAGRECIVPAPSDYVILPKAPEALHCKAVMHHYVAESRRWYYQHNWRRFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF0</accession>
    <name>A0A139SKF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712381.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35033">
        <property type="protein sequence ID" value="KXU35033"/>
        <property type="gene ID" value="AXK12_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007236">
        <property type="entry name" value="SlyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04102">
        <property type="entry name" value="SlyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="79" mass="8948" checksum="99AB75D4997EF7A9" modified="2016-05-11" version="1">MSNENADTAEHLHRLGERLTALERHVFEQDKEMLALSRQLEQLRAALLGLRERLSEPSSRDIGGGDASHAFDAERPPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKJ7</accession>
    <name>A0A139SKJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712364.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00180"/>
    <dbReference type="EnsemblBacteria" id="KXU35024">
        <property type="protein sequence ID" value="KXU35024"/>
        <property type="gene ID" value="AXK12_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="269" mass="30602" checksum="13356A7217A0D596" modified="2016-05-11" version="1">MPASSCPRGEGQRPLALRVLTFNIAHGRGLTPIQGLTLRHKLRVNLRRIARLILKLKPDIVALQEIDHHSRWAGNFDQLDYLRWHTGYPHAVFGINNRREGFMNLSYGNAFLSKHPIVDWESRAFGAARVGEKGFLYAEFDCAGRRLPLVNMHLHYRSRGRRFAQVEQVMDYVAAKHAARRAQWDLLPIVCGDLNNVAHSPDATAELLRYFSLHGHYSLHPQGGLTFPSPLPSRGLDFIFLPPGCGEVRCEVVPSYLSDHRPVWVEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKK1</accession>
    <name>A0A139SKK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712369.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00200"/>
    <dbReference type="EnsemblBacteria" id="KXU35027">
        <property type="protein sequence ID" value="KXU35027"/>
        <property type="gene ID" value="AXK12_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="350" mass="37467" checksum="0DEEDA3B4903304E" modified="2016-05-11" version="1">MTLFVLVLLAALIFEYINGFHDTANSIATVVSTKVLTPRQAVVWAAFWNLVGALMGTAVATTIGRGLVDTNVIDMTTVLSALLAAIIWNLFTWWLGLPSSSSHALVGGLCGAALTASDGNWHVLHWHLIAEDGSHSGLWPKIVLPMISSPFVGFLLGAALMYLLLALLKKLRPRLIGMIFGKAQLVSAGFMGYSHGSNDAQKTMGIITLALFTGTQAGIFEGLPGWASFLETPEFTVHRWVMITCALTMAAGTAAGGWRIIRTMGHKMVKLQTIHGFAAETTAALVIHGASTLGIPISTTHVITTSIMGVGSSKRFSAVKWGLVERIIWAWVLTLPITGLLGYGIEKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKV8</accession>
    <name>A0A139SKV8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712150.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05715"/>
    <dbReference type="EnsemblBacteria" id="KXU35201">
        <property type="protein sequence ID" value="KXU35201"/>
        <property type="gene ID" value="AXK12_05715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="427" mass="45919" checksum="3AAC5B3E8102ADE3" modified="2016-05-11" version="1">MQTNQVPRVAIIGGGAAGFFAAITCAQANPHARVALYEATAHPLAKVRISGGGRCNVTHACYEPRDLVRHYPRGARELLGAFHRWQPRDMMAWLTTRGVPLKTEADGRVFPVSDDSMDIVSCLRRAAAEAGVVLRIKTGVRSVERRPPSAETSPASAPLRLILSDGTQPECDRLLLATGGGRSENGGLKFARELGHTIEPPVPSLFTFHIDDSRLRDLAGLSVEPVALSILGGDAGMKKLTSEGPLLITHWGLSGPAVLKLSAWGARAFAACEYAFTLQINFVPAQHRDALQRELATLRSTQPRRSIARAHNPFGLPARLWERLVLSSGIPETQPCAELSKARIATLAETLAAAEFRVRGKSTNKDEFVTCGGVRLSEVDFKTMQSRLCPGLYFAGEVLDIDGVTGGFNFQAAWTTAHLAGTAMAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX5</accession>
    <name>A0A139SKX5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35218">
        <property type="protein sequence ID" value="KXU35218"/>
        <property type="gene ID" value="AXK12_05815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299313" evidence="2">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="530" mass="58774" checksum="791C14EE3692DD0D" modified="2016-05-11" version="1">MAVLIPALLGSACALFIAPPVINADPAIGLMSWLNFVEGGTWNTILTPDSNNIAENIEYPVTWWAPGQYIPIGILHTLGFSLGTASIIVSALGLLLFGLGFAALARSMEIPNQSLPWVTAVACSTHYMLYSFGHFIGGETAQIAVWPWAAFTAWTLRKRTIPFIIVLPLVFLIGAFGKHSFAIYSLAILVFLWAEALRDAKARGYSPTSLRLLWSASYPIVCVGILFILGRHFLIDTSHTPGTQGMTDRNFWESLGFSFFGPIFGLLGIDRIVGYLSYHFFGIKSEDAWTEFSPTLSLLSPLPLALYVWLTLRRALVDRIAGITALIVGLIFFALLWSGGAISYESRHYQPVAMLLLLALGLRLTDPNRLLSWGSRVILTSIVLFGCATLLQRHLNMASPQTHLSYAKAENIMCDLPQPVQKILQRLAGEENSIIVATDPGDILITNRSRHPTTRFMLIDIVNPIERHGRAPRLAFAMRAEGVDLERAPIIRESFKDYDPEEWTSYEVDGWVIWQAGDVIPLREAETERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ0</accession>
    <name>A0A139SKZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05845"/>
    <dbReference type="EnsemblBacteria" id="KXU35223">
        <property type="protein sequence ID" value="KXU35223"/>
        <property type="gene ID" value="AXK12_05845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="555" mass="59605" checksum="5296867BEDD1610E" modified="2016-05-11" version="1">MTQEGIASRPAVSRSWTVIHSCAHGTGTHSQVRPAPTRPPPFPPHMPFSPIPLGHAIPDLPHAVSCSLPTMRAVCGYEVKAPEVIAAMRGGYPRFVLHRFVKKLTDHYAKACGSARYLWLTSSAQMAEQVRRELARSGHTAQVHDFDGIDGVSHDDSPAIAQLARLFLQNTGGFLASRAAEDRLAQLGLVPAPQPEAAFGNGAPDRALVEIRRQLAPLFPENSPDSLMLAPNGMNAVYAAFSALAEAQAAQGRHTWVQLGWLYLDTIALLKHHARDNAQHYCYLPDVFDLAALETLFAQRGAQIAGLVIEAPTNPLIQTPDLPAIYTLAKKHGAAVIVDPSVSSIYSVDVLPYADVVCSSLTKYTASEGDLVAGLVVVNPHCANADSLHKSISTRLDPVYPRDLARLAHQIAATPDVLAKVERSTATVAAWLEAHPSVKRVAWAHSPESRANYQKLARHPDAVGGLISFTLRGPIEAFYDAVSLPKGPSFGMQTTLLCPFIYLAHYDLVTSEAGRRELAASGLEPELLRLSVGCEPVEDLIAALDAALSQAPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKZ1</accession>
    <name>A0A139SKZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein AXK12_05840</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712206.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05840"/>
    <dbReference type="EnsemblBacteria" id="KXU35222">
        <property type="protein sequence ID" value="KXU35222"/>
        <property type="gene ID" value="AXK12_05840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="113" mass="11829" checksum="3D5B164E6B159373" modified="2016-05-11" version="1">MADLKKPASRDSAQQPHCLLTIKAVPNAPKSALVGWLGDALKVRLKSPPVDGKANAELCRFLAEILHLPRGAVTLATGAAAREKRVRIAGISLEQVGEKIAALLIANGQPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL00</accession>
    <name>A0A139SL00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712247.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35241">
        <property type="protein sequence ID" value="KXU35241"/>
        <property type="gene ID" value="AXK12_05955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="78" mass="8485" checksum="DBB79C7ACB343EC9" modified="2016-05-11" version="1">MQPVPSPLSTPPPPPLRSHWQRVALPVQLLAIILGIMLMGSVVRCEYKQPTRSAEPQPSSESESTTEAEGAEQPPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL20</accession>
    <name>A0A139SL20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsmA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712269.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06010"/>
    <dbReference type="EnsemblBacteria" id="KXU35252">
        <property type="protein sequence ID" value="KXU35252"/>
        <property type="gene ID" value="AXK12_06010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="687"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="975" mass="106061" checksum="6BAC04A17985E525" modified="2016-05-11" version="1">MFAQGLKLCRYCLACFCCWTLWLGLLGLLGFQIYAAATKQMPMPAFLLHSLERQLARADITAQLGKTRFDPTGQIVIEDLRLSLPQFSEPVARIGSVYIQLDPWALLTRRFKADSMRASDLALYIPASLSGSGTREPLIEHAELALSTHAHQLDITQLSARIGGLNGLAISAKGSVDTRLLLRHAKPRGEAPLSVELFARYYPQLCQRLGELAQWTAGLSEARLDLDLAPSSTAGAVARLTLSGSGYEAPEEAALPFSLKRFRATTRIPLHSEEPSPAELSLELDSLALPLSALPLLTENASARAPALAERDIELVGLRAKLFGKIDTAQLRFSADTTEAELRALHFAGAAPLTAQNLSLRADFNAWPQLRASARLEVEATPLSLAATVDTADHSAVVNASGQLAPSLIALISEWTAADIGRFLTLRTPPDIDLEARFADGHFTALEGDFDAQAVLARGVTFDQIGGHVRLADGRFEAPLAYAAVGPNHARGSYSHNLATHDFRFLLSGQLDPLNIAAWFRPWWSEFWQKFNFPKNPPTASVDVQGRWGDPHYSRVFVYADVPNANINGAALHHVRTRIYVRPNYYDAMEVAVRYGAQSARGWFTRRNDPTTKQLARQDFDFTSTLDLERVGALSGPEVQAAIAPFHFAEPITLEAAGYVAAHGKRHLTLHGRTRGDFSLYDFPLNGLNFTATIDDDTLLVDSLSAGLAEGIVSGRVHLQGQGDSQTLGFDLSLAEGKFYRWTGILSQYFARRRGEDPPPNVEKNTNVTLALDLSAEGNPHDPLSFIGSGNMELKGRGLGQIHLFGLLSELLSFTSLNFNQLLTSFSVEREKLVFPEVNITGSNSAITASGHYAMDRGNLDFRARVNPFGESKFILKSIVGLMLTPVSNALEVRLTGPLDKPQWSFLHFSPNPDKRNGDTSEAAQLAPESAQPSEEIANPEEQASDAPASSPSPPANGPPPSAPPQEMPTVPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL53</accession>
    <name>A0A139SL53_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYZ2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05410"/>
    <dbReference type="EnsemblBacteria" id="KXU35288">
        <property type="protein sequence ID" value="KXU35288"/>
        <property type="gene ID" value="AXK12_05410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYZ2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="233" mass="26659" checksum="129D537A56195C3B" modified="2016-05-11" version="1">MLPDFARYEAVAERKEAFFGYFLPLAQEANAEILKDRGRLLRIRRKLVLAEKRTEKKGKVAHVRGREARWLRRLAEAYGLDRPEKREELNLRFVDDVLLRVDVIPASLVLAQAANESAWGTSRFARQGNNFFGLRSTDGSGLVPKRRARGAAFRVAAYASPRESVRAYIQTLNTQLAYRRLWAIRAEDRRLGRKPSGLRLANGLHAYSERGEEYIRIIQSMIRSNGLAPYDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL60</accession>
    <name>A0A139SL60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712044.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35291">
        <property type="protein sequence ID" value="KXU35291"/>
        <property type="gene ID" value="AXK12_05430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="131" mass="14978" checksum="234A05AA378477BE" modified="2016-05-11" version="1">MKTPKPTNRHLWLLDPLADEPTLIVRSMFVGQAVYLDGRMVLYLADRAEPWRGVCVPMERDQHPALIAELPALAPHPELPKWLYLPESADTFERDAEWLVSRIQARDSRIGITPTPKKPKRHNPLEQNAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE2</accession>
    <name>A0A139SLE2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="9" type="ORF">AXK12_05250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711964.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05250"/>
    <dbReference type="EnsemblBacteria" id="KXU35378">
        <property type="protein sequence ID" value="KXU35378"/>
        <property type="gene ID" value="AXK12_05250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="87" mass="9050" checksum="83D4504C92AB8973" modified="2016-05-11" version="1">METLVTAATTPPFAPLAVFGIGVPELLLIFGVLILLFGATKLPSLAKGLGQSIKEFKKATQDDETPPAPKSEQKPTATPKDDSNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH0</accession>
    <name>A0A139SLH0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712007.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05365"/>
    <dbReference type="EnsemblBacteria" id="KXU35399">
        <property type="protein sequence ID" value="KXU35399"/>
        <property type="gene ID" value="AXK12_05365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="30294" checksum="5871AD6A9409F10D" modified="2016-05-11" version="1">MQTIGERLEEARKNKGISIRDAAEATKIRSDYLHKFESNQFDIGLAEIYRRGFLRTYALYLQLPAEKILSDYTALARTQGTSNNNGRGNRSLSREVFVRMDLSSSTTGEDATTAPPHPAAGDGASTNAPPSKRAEASRSGTNLPKLPAIPPQWIFRGGIALGSLVALLLLYWVGSALFGSGKSEGQSTGTGAGTPTLGAVADTTFSLIATNTVRVKVTRRNADDSAGEVLLDDITLNRGDRRTLSAPGPVYIWASEGGNLKIEKAGREYPMPFSGYNRAKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLH3</accession>
    <name>A0A139SLH3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="7" type="ORF">AXK12_05325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05325"/>
    <dbReference type="EnsemblBacteria" id="KXU35392">
        <property type="protein sequence ID" value="KXU35392"/>
        <property type="gene ID" value="AXK12_05325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="526" mass="58811" checksum="55FBAEF41E4B20C9" modified="2016-05-11" version="1">MPALSISLTLVFLAAAMRLDWSLAVYVLVGMGIGFWSIWAVTRSIRREARKSAETILQVAKREAAVAAEEVRQKAAERIRKKRAALVEEFAAKEVDAEVRLREIRAHEESLALLDHQLEQRTERLNRELAAVRQTRETITALSANVRERLEGISKMDTEAMKRALREEVILECQDELRQLRREIMERSEQELEMQARDKLVTVMQRIAVRQSHDLSATIVQLPSEEMKGRIIGREGRNIKTFEAATGVTLLIDETPQTVLISSFDPVRREVARLALEALVKDGRIHPATIEEFVKTAQSEIDSSADLAGEEAVTRLSINGLHPEVISLLGKLKYRFAYNQNVLDHLIECAYLASMIASELGLDANVAKRAALLHDIGKAAPAGYEGSHARVGAAFIKRYGETPIVVNAVEAHHEEVKPETIYAGIVILADTISAVRPGARAESVTNYIQRLERLEALANAIDGVQQSFAIQAGREIRVVVSPDAVDDDRAREIARELRQKVETELDYPSTIKITVIREKRFTETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLM1</accession>
    <name>A0A139SLM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000041">
        <property type="protein sequence ID" value="KXU35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711935.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05155"/>
    <dbReference type="EnsemblBacteria" id="KXU35451">
        <property type="protein sequence ID" value="KXU35451"/>
        <property type="gene ID" value="AXK12_05155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="28664" checksum="79BDA36CAF0E7802" modified="2016-05-11" version="1">MPDFRVFCEPTSAEPTALTLSPEESRHLVAVNRARLGDTVVAFDGRGNEWIGELTDTSKAAAVLRVRFAQKIPPLPYTITLGQALPKGDSMERIVRKATEIGCARIVPLESERTQVHLAPDRQDKKHDKWRTAALEAAKQCGNAYLPEIAPLQTATAFMEATASTSAQSFQSRYDLKLIASLQPGAKSLKAQLADFAAAHSNDTAQARPKNVLWLIGPEGDFTPAEMSAAASCGFQPVTLGPLVLRCETAAIYALSILSYELQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM12</accession>
    <name>A0A139SM12_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">AXK12_04960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711860.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04960"/>
    <dbReference type="EnsemblBacteria" id="KXU35603">
        <property type="protein sequence ID" value="KXU35603"/>
        <property type="gene ID" value="AXK12_04960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="133" mass="14277" checksum="C48170EC9EAB8A1E" modified="2016-05-11" version="1">MSIEDSSVITATGRRKTATARVRIIEGTGKLIANGRSFDAYFPPESFSKAASAPLATAELRDKFDVTANVSGGGVAGQAGAVAHGIARALQKFDPELRAVLKKAGHLTRDPREKERKKPGQPGARKRFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM20</accession>
    <name>A0A139SM20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">AXK12_04990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711867.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04990"/>
    <dbReference type="EnsemblBacteria" id="KXU35607">
        <property type="protein sequence ID" value="KXU35607"/>
        <property type="gene ID" value="AXK12_04990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="273"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="410" mass="43041" checksum="98669433140DD0AF" modified="2016-05-11" version="1">MAAPTHTTPFASRKRIVLLGATGSIGESALRVIAAYPDRLELVGIAAGRNWQKLAQIAQRHPSVRHVAIHDEAAFRDARASAAFAAGTTVHAGLGGLCELAQIAEADLVLVAIVGTTALEPTLAAIAAGKTIALASKEILVLAGKFVMAAARARGVALLPVDSEHNALFQCLERGNPAGLKRIFLTASGGAFRDLPVEALAHVTPADALKHPNWAMGAKITVDSATLANKGLELIEAQWLFGLAPQQCQAVLHPQSIVHCLVEYADGSLLAQLCPPSMTFPIQHALLYPERAPGVEPTLDFAQTLSLDFRPIDLDRFPMLRLAHEVMRAGGDPCGSTGGGSTAPAIYNAANEVAVAAFLAGKLPFLAIAEVVDKTLQRLPHTEPRDLADVLATDAQARQIATDLAAKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM24</accession>
    <name>A0A139SM24_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">AXK12_05050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711888.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05050"/>
    <dbReference type="EnsemblBacteria" id="KXU35617">
        <property type="protein sequence ID" value="KXU35617"/>
        <property type="gene ID" value="AXK12_05050"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023228945" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023228944" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="203"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="445" mass="46814" checksum="C9D2BBFAD3D18CE9" modified="2016-05-11" version="1">MPSTDLVFPSCAAHRRWLAAQAALPRGFRVGTAKFAFTPREAPKPSEMTLTLISLDAPTRDFAAVFTRNAFPGAPVVIGRERLQERELGAIIVNNKISNVCAPEGRAAAEAVCTRVGELLGLPASAVLPSSTGVIGWSLPVEEMLAALPSAKAALQADSILPAAQGIVTTDLYPKVRRHDFANGGSLVGVAKGAGMIEPNLATMLVYLLTDVAVPREALREMLRRVVEPSFNSISIDSDTSTSDTVAVVSSGRVACEDLGAFEEALRVVCCDLAEDVVRNGEGVRHVIRVAVTGASDAGQARSLGKAIINAPLFKCAVAGNDPNVGRLVQAIGKGAETASFGTGGVGAALMERLRLTMGGIEIFSDGVFQLDPQKEATLVAHLKQAELYESRLPADGIYRAGVDYPPHERCVEVGVDLGAGDRTATVLGGDLTHEYVSENADYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM68</accession>
    <name>A0A139SM68_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711754.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04685"/>
    <dbReference type="EnsemblBacteria" id="KXU35668">
        <property type="protein sequence ID" value="KXU35668"/>
        <property type="gene ID" value="AXK12_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="252" mass="27391" checksum="E070E56A5C2907D2" modified="2016-05-11" version="1">MPPHKIKILTYNIYHGEAFYRPGTPNLQEVAKVIDACQPDLVALQEVDRFTQRSAQLSGGTPQDLCAELAKLTGLHGVFGKAMDQHGGDYGEAILSRLPLDLALSPPTTRILPTPEGGESRALLTIDYPLGRGEKITFAATHLCHQHEANRLAQVKGIIQVADALDGPFILAGDFNFETGEAPYHVLAAAMKDTGVTAGNTALTWPYDAPTTRLDIVFVDKKHNWAVKDVALIDNDASDHFPVLVTLELHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMC8</accession>
    <name>A0A139SMC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711800.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04695"/>
    <dbReference type="EnsemblBacteria" id="KXU35692">
        <property type="protein sequence ID" value="KXU35692"/>
        <property type="gene ID" value="AXK12_04695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="330" mass="34167" checksum="35AD5F910D619E49" modified="2016-05-11" version="1">MSGALTTSEQGRGEVPLAITCGDPAGVGPELIERILGGQGAPPVSFSGPLAVIGAEQWLRSLPDFVEKIAVGDSAFRAQAGVPSAAGARVALEAMECAAAGCVAGRFSGVVTGPVSKAELAKIGYPFPGQTEFFASRWGGDQCGSAVDEPVMGFVGERLRVVLATWHVPLAEVPNRLSEAVIERTVAAAGELARIGRAASEPAARIAVCGLNPHAGEGGLLGVEERDFLNPILAKLGGRYPGLVPQCLPGDTVFARALRGDFDVVVALYHDQGLAPLKAVDFDTAVNVTLGLPFVRMSPDHGTAFDLAGKGTASPRSFANAIRLARHWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SME0</accession>
    <name>A0A139SME0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization protein EutJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04750"/>
    <dbReference type="EnsemblBacteria" id="KXU35679">
        <property type="protein sequence ID" value="KXU35679"/>
        <property type="gene ID" value="AXK12_04750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299349" evidence="1">
        <location>
            <begin position="26"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="39"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="394" mass="41237" checksum="46C9503EDE3A00E5" modified="2016-05-11" version="1">MYLLSPNLRCLLIATLALPLCFALAGCPSKGGGDEAGDPILIGEISSITGKEGAFGQSAHRGIVLAIEEANARGGVLGGRSLRLLTEDNQSKAGGSGTAARKLISRNKVVAILGEVVSSRSLEIASIAQLTHTPMISPASTAESVTQAGDYVFRVCFLDSFQGTVMGKFAYEMLGLRRVAILSSVSSAYSVGLAKHFKETFVGLGGTIAVEQKFAEGDKDFKAQLTAIRASGIDAIYVPAYYTETALISKQARELGLTIPLMGGDGWGSPELLEIGGAAVEGIYYSTHYSPESTAAQVVEFVSKYRERWGGETPDAFAALGYDAALLLIDSLERAGTTESAALRDAIAATRDLLGATGRTAIDENGNASKAATIMTVKNGRFTYVGEVASEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMG3</accession>
    <name>A0A139SMG3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35674">
        <property type="protein sequence ID" value="KXU35674"/>
        <property type="gene ID" value="AXK12_04725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="189" mass="21622" checksum="048D5D0EBEFFF06A" modified="2016-05-11" version="1">MSFVFLATLALWDQSFKFYTFPFYDNLFIKERVVGDQDLVLKLEERLSEGAMIYTLPAFVFPEPFNGPGPNDIKFFLYNSIRPFLYSTKLRYSYGSNKGREGADWQLAVQELPPREMATKLESYGFSGILLDRKGYADRGEQLLAELAAGGWPMEFEQGLDNEWVFIRLSPAENPVLPTLTPYALSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMI7</accession>
    <name>A0A139SMI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine biosynthesis protein MetW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711777.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04755"/>
    <dbReference type="EnsemblBacteria" id="KXU35680">
        <property type="protein sequence ID" value="KXU35680"/>
        <property type="gene ID" value="AXK12_04755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010743">
        <property type="entry name" value="Methionine_synth_MetW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07021">
        <property type="entry name" value="MetW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="202" mass="23141" checksum="743E3D608C1F68DD" modified="2016-05-11" version="1">MPLPTEKRTIDMEIIGQWVQPRTHVLDLGCGRGELLTYLKQTKDIAGIGVDQDFGKITACVRRGVTAYQGDIHTFTRRFDDGHFDHVICSRTIQELSNPSAVILEALRVSRAVTVGFVNHGYWRNRFAALLRGRKPRNAIYTTEWFESRPANPLTIDDFEHFCAVKQIRILRHAHLLGDWKSPCHWRPNLRAGYALYELGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN67</accession>
    <name>A0A139SN67_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711502.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36018">
        <property type="protein sequence ID" value="KXU36018"/>
        <property type="gene ID" value="AXK12_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="285" mass="30833" checksum="5259DD7B428A4188" modified="2016-05-11" version="1">MISDKKFIELLNLYLDHEISADEVRVLEAEILSNPARHTLYRQYCAMHKGCLELARTFAPQSEMTAAQSASLAPKVARDLEASRAKFGWGAWVGGLGLAAACGALVFFVFSHKHRSAPALSGGTDTFAPALLAAPRAAPLNSPTPSPVTIATPLRAHAGEGRALLAGGGDKASLAGHAFATAAALSAPAPASEQLQAAYSPEYEPSHPATPFHFSAVYTAGPTAMERERLDWGPLIDLREIMEQQTTLPSFRVRPSVTPSPRVYHRKERRFEGGRVEMTRFQFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN74</accession>
    <name>A0A139SN74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_04445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711621.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04445"/>
    <dbReference type="EnsemblBacteria" id="KXU36073">
        <property type="protein sequence ID" value="KXU36073"/>
        <property type="gene ID" value="AXK12_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01821">
        <property type="entry name" value="Helicase_RapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023949">
        <property type="entry name" value="Helicase_RapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022737">
        <property type="entry name" value="RapA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040765">
        <property type="entry name" value="Tudor_1_RapA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12137">
        <property type="entry name" value="RapA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18339">
        <property type="entry name" value="Tudor_1_RapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="178"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="491"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="973" mass="107821" checksum="9BF7F2DC11124759" modified="2016-05-11" version="1">MTLTQVGQRCVSEREPELGLGLISELDHNQITIEFPATRERRIYARGTPVLRRVRFKVGDKIATRSGTAFTIEAVLGSDSAPDADGSSPSENTEPATGLLTYLGNGGALHVAESEVADATSANSPADRLLTGQAEPSEVFDLRYRTLQWQATLARSEVRGMLGGRVDLIPHQFYILGEVSRRQIPRVLLSDEVGLGKTIEACLILQRLLATGRAKRALILVPESLVHQWFVELLRRFNLWFTLFDEARLQATEASEPEKNPFHSSQLWIAPTSTLANHETRRAQAIAAGWDLLIVDEAHHLGWSPQDASSDYQLVESLAQTTPGLLLLTATPNQLGASGHFARLRLLDPHRYSDYEAFLEETEGYASIADVADALVEGRPLSKSDHKALLKIFDRDPEGLASHLSALETGGAEARAALLRTLLDQHGTGRMVFRNTRTAMKGFPKRQYCPAPIEGATAEVLDRVAREIETEEGSAPHAATRLAYTFKDDPRLDWLLGFLKKHAREKVLLICKTARKALALEEAIKERLNLNLALFHEGLSLIHRDRQAAWFAEPDGAQLLICSEIGSEGRNFQFAHHLILFDLPLNPGLVEQRIGRLDRIGQTEAIRIHVPYLPGGADEALAHWYHDGLAAFEAPLHGGNEYRDHYHARLLELVAEYAAGDEARAAARPKLEKLIAETQKFRAALNQKLSQGRDRLLELNSYDAPCAAALLEKIREADRSPTLRTNLTALLDHFGVRVTDHEDGDVSLDASQAYVEAFPGIPAEGGMLATYSRTRAISREDIRFLSADHPLVQDTIDLLVNSTTGTTAFCLLESDTPNLLLEAVFVLETIEDTRWHLDQFLPPTPLRVLVDIHGRDRSAELSPEAFARDLEDAPLPQFLEKPGFNATLLKALLEGATERAEAHAAPLRQAARETAATALTDELQRLVHLSKLNRSVSPREIELAKKQVRQTRKAIEASRLRLDSIRLILEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN91</accession>
    <name>A0A139SN91_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_04110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711506.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04110"/>
    <dbReference type="EnsemblBacteria" id="KXU36019">
        <property type="protein sequence ID" value="KXU36019"/>
        <property type="gene ID" value="AXK12_04110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299334" description="OmpA-like domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="186" mass="19947" checksum="C2F5DE01EB8EAAB0" modified="2016-05-11" version="1">MNTIAFKKLFLVLLSAAALSSGCLKKPQRPDPSATVLGGGAGSGYDSSLDPIDLSLLAPGTGLEGRGAGFDLNGQMRGVLEAVYFDFDKSSIKAEERAKLQAAAEHLRNNPSHRLLLEGHCDWRGTAEYNLGLGDRRANAARQYLGTLGIAPNRLETLSKGSLEAVRNADRETAARDRRVELVVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN96</accession>
    <name>A0A139SN96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711562.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36045">
        <property type="protein sequence ID" value="KXU36045"/>
        <property type="gene ID" value="AXK12_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299345" evidence="2">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="165" mass="18492" checksum="D4698B2BC274BE44" modified="2016-05-11" version="1">MRRLSPLPLLALLVLLCAPRSAAAKSETADNDDGPPRPAHTSPNEKGEDRVQQLPELVISSSRITALDVQIGKLTKKIDRARRRLKKSSSLDESLNTDDIPKLLSILGGYTTGQRKSLARERLMLMEAERSILEAMKHVRSYREEQELKTQLHTLKSMALLLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA9</accession>
    <name>A0A139SNA9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711688.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04590"/>
    <dbReference type="EnsemblBacteria" id="KXU35964">
        <property type="protein sequence ID" value="KXU35964"/>
        <property type="gene ID" value="AXK12_04590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="111" mass="11977" checksum="491964E17563D39C" modified="2016-05-11" version="1">MTLFEKIIAREIPATIAHEDEHCIAIHDIDPQAPVHLLVIPKRVITRVGEAQQTDANLLGHLLLTAGQLARALGLAEGFRIVINNGPHGGEAVPHLHVHLLGGRPLTWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNB4</accession>
    <name>A0A139SNB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">AXK12_04470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711630.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04470"/>
    <dbReference type="EnsemblBacteria" id="KXU36078">
        <property type="protein sequence ID" value="KXU36078"/>
        <property type="gene ID" value="AXK12_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="178" mass="19367" checksum="A5A2B6F758423CA9" modified="2016-05-11" version="1">MQATRKPFPECPFEKRFPSQLVRDDTFFMSLAYNQAIDAWRRGEVPIGAVIERGGEVIALAHNTVETAHDPTAHAEVLAITQAAAALGDWRLEGCTLYVTKEPCPMCSGAVLMSRLARVCYAVRDAKMGCLGGATDLNAIATLNHHLEISAGEILEAECRTLLQTFFKLKRESSAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND1</accession>
    <name>A0A139SND1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">AXK12_04465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711628.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04465"/>
    <dbReference type="EnsemblBacteria" id="KXU36077">
        <property type="protein sequence ID" value="KXU36077"/>
        <property type="gene ID" value="AXK12_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="86" mass="9858" checksum="D0235CE6B52CEDCA" modified="2016-05-11" version="1">MADVNAIEVEGKVVAVLPGTMFKVELSNGHVVLAHISGKLRKHFIKIATGDTVKMEMSPYDLEKARITYRVREQNAHRPNFQRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND5</accession>
    <name>A0A139SND5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711644.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04510"/>
    <dbReference type="EnsemblBacteria" id="KXU36085">
        <property type="protein sequence ID" value="KXU36085"/>
        <property type="gene ID" value="AXK12_04510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="403"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="521" mass="57484" checksum="1E8D410F0DB52444" modified="2016-05-11" version="1">MNASHSENYRPLYHFSPRKGWINDPNGLLYLDGTWHLFFQYYPHAPIHGPMYWGHATSCDLVCWQEQPVALCPQGSIYMFSGSAVVDYGNTSGFGDGTTPPLVAIYTAHDIAETDPNQVENQALAYSLDGGMTWAQYAGNPVLQSPGLPDFRDPKVSWDAECGRWLMVLAAGDRVHFYESADLINWRFLSEFGAECGAHGGVWECPDLFSLPVKNEFWEDGLDADDSEGCAPEKEKWVLLVSINPGGPNEGSATQYFVGDFDGTTFTLDESQPCASARWVDWGRDNYAGVLFNNVPGDRRVMIGWMSNWDYAAELPSAADGWLGQMTIPRELSLVVNSEGYVLKSYPVPELFARREQGSRLFRCGKVEVANEEVPMIPFGELDLKRGMIKVSLHGLGAGQSTITFRNPWGQELRLGVNNVEGSARAELFVDRSDAGSEVLPKNFPVPLMVAPLAGGMRNSMRMLLCLDKTSLECFANRGERCVTASVYPSAAFTEMGFSAESTGATFSLEAYALHVDNCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND6</accession>
    <name>A0A139SND6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_04625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04625"/>
    <dbReference type="EnsemblBacteria" id="KXU35971">
        <property type="protein sequence ID" value="KXU35971"/>
        <property type="gene ID" value="AXK12_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="250" mass="26949" checksum="9555859904DF3656" modified="2016-05-11" version="1">MKHLNAILAGFGSTVLLLLNSLRQVGSLPRQFARLAEQCYLIGYTTLPIVAILSFFIGGVLALQSGYSMSNFGTKEFIGSLVGLSMTRELGPVMVAVLLAGRVGSAISAELASMKVYQEVDALVTMNIPPERILVLPRLAAVLVMMPILTLIGILVGWFGGALVCQYVGFISLSPEKYFETLRRYTDFHDVWSGLVKAEIFGFVVVLVSCSIGLNTRGGPREIGASVTKAVVTSLILILVLDYFVTKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNF4</accession>
    <name>A0A139SNF4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711680.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04405"/>
    <dbReference type="EnsemblBacteria" id="KXU36105">
        <property type="protein sequence ID" value="KXU36105"/>
        <property type="gene ID" value="AXK12_04405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="30429" checksum="5D6986207E5EB780" modified="2016-05-11" version="1">MMTSHLSIIAPGLLGASVAKAAHERKLAGRVSIWARRAEVRRAITQQPWCAAAPEALADSVREASLVVIAAPVTHIVPLICELAPQLPAGAIVTDVGSVKGEICRDAHAALVGTHAHFVGSHPMAGSEKTGWEHAQADLFEDRTCFVTPLIESDRHATETVSRFWQALGAKVVQTTPTAHDEIVAHISHLPHALAATLCAALGRKDANWPAYAGGGLRDTTRIAGSDPQLWRTIFEQNRDAILRALDHFEAELCGFRAALAAKDYDALTDTLARGRHYRQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG0</accession>
    <name>A0A139SNG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_04075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711494.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04075"/>
    <dbReference type="EnsemblBacteria" id="KXU36014">
        <property type="protein sequence ID" value="KXU36014"/>
        <property type="gene ID" value="AXK12_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="6"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="309" mass="32597" checksum="46328E3086AA28B2" modified="2016-05-11" version="1">MALALLFSGQGAQKVGMGRSLYEQSAAARARFDEADSILGWSLTRTCFEGPEEELTQTKVCQPALYVHGLALLAALEEQGKLSATAAGASQPSPRYALGLSLGEITAYAAAGVFDFATGLRLVAERGRLMQHACEQTVGSMAAILGESREAVAVLCKEFDIEAANFNAPGQIIVSGEREKVAAAVAASKAAGKKVIPLNVAGAYHSRLMESARAAFADVLREVEFSRPAFTVFTNTTGRAISDPEELRAALAAQVVSSVLWEDCMRSAVAAGASEFWELGPGGVLAGLARRTEKSWAVKSFSEFDDLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU6</accession>
    <name>A0A139SNU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">AXK12_03980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711456.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03980"/>
    <dbReference type="EnsemblBacteria" id="KXU36182">
        <property type="protein sequence ID" value="KXU36182"/>
        <property type="gene ID" value="AXK12_03980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="242"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="269"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="513"/>
            <end position="516"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="603" mass="66924" checksum="90089A5152639233" modified="2016-05-11" version="1">MTALNASPLSANENLLKWVDKMAALCQPAAIHWVDGSQEEYDSLCAQMVATGTFVKLNETLWPGCYYARSDASDVARVEDRTFICSLSPESAGPTNHWVAPDQMRSKLRGLFKGCMRGRTMYVLPYSMGPVGSPLAQLGVQLTDSPYVVVNMRIMARIGLPVFKEIDKGEKRVVPCMHSVGAPLAPGQADVPWPCNPDKYIVHFPETREIWSYGSGYGGNALLGKKCFALRIASAMARDEGWMAEHMLILGLESPQGEKTYVSAAFPSACGKTNFAMLVPPDSFAKQGWKVWTVGDDIAWIRPDASGQLRAINPEAGFFGVAPGTSVKTNPNAMAALAKNTIFTNVALTPEGGVWWEGMTDEPPPALTDWQGQPWTPDCGRKAAHPNARFTAPASQCPTIDPDWEKPEGVPISAMIFGGRRATTMPLVYQAFNWSNGVYIGATMGSEMTAAAAGTIGKVRRDPFAMLPFCGYHMGDYFRHWLAMQKKLVVTPRIFHVNWFRKDAEGKFMWPGFGENMRVLKWIVDRAHGHALAREAPIGWMPRYDDIDWDGLDFSREAFEQLQAVDRAAWHAEIVGHEELFIELHDRLPKEMVYERELLIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNW6</accession>
    <name>A0A139SNW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36194">
        <property type="protein sequence ID" value="KXU36194"/>
        <property type="gene ID" value="AXK12_03810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="451" mass="50509" checksum="F888C09E00998A8C" modified="2016-05-11" version="1">MLVILAIAGVTSVLVAWLPKREAAGIVFWLTSGRHEVAYQPVVAQWNEASRARRFGSQPSLAMTRMANRSFEQLMLSGFLSGTPVADLLESSDDTIPRAFLGPVEQVGFVDLTQRLREEGIYERFELRAFDPFTSRGHIFGLPRGVHPVLLAYRADIVEAAGIDLSQVETWEDYFRAMRPLMADNDGDGQPDRYLLSFNEVATNELTILMLQNGGVFFDDEELPDFANEKNAHVLATVVSWMTGPDRVAQTTTPNSHLRNPDGFALAVPMPDWLLSVWKMELPMLTGKLKLMPLPAWERGGRRTSTRGGSMIGINRRSPHAEAAWEIAKTLYTSREVAEQLYRETSIISPLKEFWGEAFYAEPDPYVSGQAAGLLYIEQAPHVPKRTSSPYAATAETYMIGAFLDLREYAEQHAVYDAEALKPVALRLLEEAQHSLRHLILRNTFLSPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNX4</accession>
    <name>A0A139SNX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_03895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711418.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03895"/>
    <dbReference type="EnsemblBacteria" id="KXU36204">
        <property type="protein sequence ID" value="KXU36204"/>
        <property type="gene ID" value="AXK12_03895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="295" mass="30821" checksum="D34C8CAC334D4D62" modified="2016-05-11" version="1">MEPVQQLINGLSLGAIYALIALGYTMVYGVLRFINFAHADVFMLGAFIGYYTAPLVPAETVWGGLAVLAAAMLGCAVVGMLIERLAYRPLRGAPTLNVLITAIGVSLLLEYSGQVFFGATPRTFPELFPAQRFTLGSLVISSNQVLVIGVTLALVAALQWIIHRTRIGTAMRAVAQNPRAALLMGINTNRVIAFTFGLGSALAGAGGILYALNYPSIDPLMGVAPGLKAFTAAILGGIGNIPGAALGGLLLGIVETLVAGSALSTYKDAIAFTILLIILFFRPAGLLGKRTTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP20</accession>
    <name>A0A139SP20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">AXK12_03770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711395.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03770"/>
    <dbReference type="EnsemblBacteria" id="KXU36272">
        <property type="protein sequence ID" value="KXU36272"/>
        <property type="gene ID" value="AXK12_03770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="13"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="478"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="483"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="483"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="778"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="809" mass="89141" checksum="9BC76F95BC52B636" modified="2016-05-11" version="1">MTTTTATTARPLTHNLGYPRIGEKRELKKATEAYWAGKLSRAELEQVGSELRRKNWETQRAAGIDLIPSNDFTFYDQVLDTSCLVGNVPPRFGWQGGQVDLDTRFAIARGVRKGGNNNDGGSAAAAKDACTCSKDQGDSADAQAATYASEMTKWFDTNYHYIVPEFRADTRFALSATKIFDEFSEALALGIRTKPVILGPVSYLKLGKVQDSQNPSFDRLSLLDSLLPVYAQILQKLEALGAEWVQLDEPIGALDLDDAERRALSTAYAALTTAAPKLKLLVTTYFGALRENLETYLALPVAALHLDATPRGDLKEIERVLAELPADKALSLGLVDGRNIWKSDLAALLPRAQAAAAKLGTGRLLLAPSCSLQHVPVTLRNEQKLDAEFKGWLAYAEEKLSEVATLASALGGQADEAALTANAAAIKSRRESPRIHRPEVKARTAKVAPSDFDRASPYATRRLAQRGANGPLATLPDFPTTTIGSFPQTPEIRAARLRHKRGELGTAEYEKFIEAETLACVRFQEEVGIDMLVHGEYERNDMVEYFGEQLDGFAFTEHGWVQSYGSRYVKPPIIFGDVSRPAPMTVRWSAYAQSLTKLPMKGMLTGPVTVLQWSFVRDDQPRRDTTFEIALALRDEVRDLEAAGIAAIQIDEPAIREGLPLRRSDWAAYLDWAVNAFRLSAAGVRDNTQIHTHMCYSEFNDIIDSIAAMDADVITIETSRSNMELLGAFVNFKYPNEIGPGVYDIHSPRVPTVDEMVKLMRKAAQVIPPENLWVNPDCGLKTRGWAEVRPALANMVEAARIIRAESAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPH7</accession>
    <name>A0A139SPH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03350"/>
    <dbReference type="EnsemblBacteria" id="KXU36361">
        <property type="protein sequence ID" value="KXU36361"/>
        <property type="gene ID" value="AXK12_03350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="268" mass="29362" checksum="06742CC636EA2F5F" modified="2016-05-11" version="1">MAAKAVRRPSPSSPELAIIVPCRLESTRFPRKLLHPIKGKPLLLWVAERISAQVPALPLWFAVDDERLRDCVEAAGFRAVMTAVTHASGTDRLAEANARIGAARVINVQADEPLVSAGQIQALVGLLERGAQMTTLATPFRRVSDFHDPNQVKVVLRRDGRALYFSRAPIPFTRDAPPQEDEAATPPRQIKGAATPYRHLGLYGYTADLLAKLGSLPRGCYEDLEKLEQLRVLEAGYDIHCALTEEPSIGIDTPEDAAAFEALSAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ05</accession>
    <name>A0A139SQ05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711210.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03110"/>
    <dbReference type="EnsemblBacteria" id="KXU36623">
        <property type="protein sequence ID" value="KXU36623"/>
        <property type="gene ID" value="AXK12_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="331" mass="34839" checksum="7FE18ECDA9B68474" modified="2016-05-11" version="1">MQAITFTAVDSLCFGSVPEPKPAQGEVCVLLRAAALNHRDLWILRGQYAGLQWPIIPGSDGAGVVSELGAGVSRELLGREVIINPALGWGESAAAQGQAFSILGLPREGTLAERVCVPADQLAPRPEHLDWCEAAALPLAGLTAWRALVSRAQVRAGERVLISGIGGGVALFALQFAVALGAEVWATSSSPEKLVRAAELGARGGFLYTRSDWAREAVEQSGGGFDVIIDSAGGPGFESLIDAAAAGGRIAFYGSTRGNVPELALRKVFWRQLSLLGSTMGSPADWAAMLDFVNRKELRPIISAHYPLAQTAEAFALMERGEQLGKIGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ06</accession>
    <name>A0A139SQ06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711199.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03115"/>
    <dbReference type="EnsemblBacteria" id="KXU36612">
        <property type="protein sequence ID" value="KXU36612"/>
        <property type="gene ID" value="AXK12_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="318" mass="33720" checksum="53338CE7E9440AEA" modified="2016-05-11" version="1">MKILITGAAGFIGSHTSERLLAEGHEVLGVDNFRTGHRRNLDAALRQALRFELVEADVAESGVLDSLCARFRPEAIIHLAALVSVQESIANPALNHRLNITATEHVASAAAKQGVRRIVFASSAAVYGDVRALPIDEAAPKQPISPYGEAKLSSESILLDSPAAVAGDCVVRCQRYFNVFGPRQDPASPYSGVISVFQNCYAAGRAPTIYGDGQQTRDFISVYDVARANALAATSARTGLASGVANICTGRATSLLESVRIFSVEYPDAPPPVFAPARSGDIVHSLGDPARARAELGFEAEWTVERALAELIRGARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ98</accession>
    <name>A0A139SQ98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEP-CTERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36712">
        <property type="protein sequence ID" value="KXU36712"/>
        <property type="gene ID" value="AXK12_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="95" mass="10955" checksum="68DCF5399647278F" modified="2016-05-11" version="1">MWVRSSGTLTVLDWKEGRDFILVKKTSKNVEDALKKMKFEGYDPSKIHLEDYNSEYWMINGAPEPATYGAGLMLGVLGLVRYRRRQKQRSARLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQC0</accession>
    <name>A0A139SQC0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36738">
        <property type="protein sequence ID" value="KXU36738"/>
        <property type="gene ID" value="AXK12_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="79" mass="8330" checksum="E42EA87DF524E9C6" modified="2016-05-11" version="1">MGEVGKITSKLSASKFGFLSTERLAAVRMHGSQALGKRVQRHAAAPRVVEKCSGSGLRAFETGAAPRAFTTLGLGAQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD7</accession>
    <name>A0A139SQD7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pgk</name>
        <name evidence="11" type="ORF">AXK12_03070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711194.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03070"/>
    <dbReference type="EnsemblBacteria" id="KXU36758">
        <property type="protein sequence ID" value="KXU36758"/>
        <property type="gene ID" value="AXK12_03070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="415" mass="43229" checksum="1FDB4BFB47B8E28F" modified="2016-05-11" version="1">MSNFKSIRDLSLAGKRALIRVDFNVPQDKATGAITNNQRIVAALPTIQHALDRGAAVVLMSHLGRPNGQRVEKYSLKPVAAELEKLLARPVRLLADCVGPEVEAACASLAPGSVVLLENLRFHIEEEGKAKAEDGSTRKADPAAVEAFRASLTRLGDVFVNDAFGTAHRAHSSMVGVALAEKAAGFLMEAELNAFNKVLAAPERPLLAILGGAKIADKIPLITNLLERADKLIIGGGMAFTFKTVLDQMPIGDSLYDEAGAALVADLAAKATARGVELILPDDFLCADSFSPDAQTQPADEASGGIPEGWQGLDAGPQSTARYCKAILSAKTIIWNGPAGVFEFDKFAGATRAMAEAVAQATARGATTVIGGGDTATAAKKFGVADKVTHCSTGGGASLEFLEGKALPGVVFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQH0</accession>
    <name>A0A139SQH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711164.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02955"/>
    <dbReference type="EnsemblBacteria" id="KXU36730">
        <property type="protein sequence ID" value="KXU36730"/>
        <property type="gene ID" value="AXK12_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="271" mass="28407" checksum="B8605CBF84836170" modified="2016-05-11" version="1">MPHPDYLNSLFGLSGKVAVVIGGTGELCGAMAEGLAGAGAEVVLVGRNADKAQARLEKIAAIGGKGWFHAAEATSRSQLEALRDAVLARSGRIDIVINGAGVNSATPFFEITEEEFERIVQVNLKSVFLGCQVFGKYLVERAAGGGDKSGRLGGAIINLGSMSAVVPLSRVFTYSATKSAVHNLSLNLAREWAPHGVRVNVIVPGFFPAEQNRKVLTPERVASILGHTPAKRFGEPRELIGATLLLASDAAGSFITGEELIVDGGYHAMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQJ1</accession>
    <name>A0A139SQJ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ORF">AXK12_03085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711185.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03085"/>
    <dbReference type="EnsemblBacteria" id="KXU36750">
        <property type="protein sequence ID" value="KXU36750"/>
        <property type="gene ID" value="AXK12_03085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="523" mass="55185" checksum="51D2F077903EE473" modified="2016-05-11" version="1">MSRKLKAIGVVSGLTVVSRVLGLVRDQLSAAVFGTSALNSAFITAFSLPNLFRRLLGEGALTAAFVPTLQEELQEGAEAAAFRLLNQVVSWLALVASGVVAAGMGLFAWGAQLPQFSGKWSLAAELTVVLFPYLVFVCLAAAFSATLNVFKRFTESALSPIWLNVAMIGALGGAGLHFAETGLGRMHWLCAGVLAGGFLQMVVPGLVLVRLGWRPRLDFTLSARVREIARLMAPGLFGVAIYQINIYVSRLLAFSVSDEAAAVLFYANRLTELPIGVFAIAVATVIYPLLAQHAAQRQSGAFAADYAKGLRLILLVNLPAAAGLALLAEPITRLLFERGSFGPSDTAMLVPLLALFAVGMPFFSITSLSTRAFYALKDTKTPVKLAAVSFVINLGLSIALMRPLGAAGLVLGSTVAIGVQAVQLQRALTVRLPELAFAPLWGGVAKLVLAVCAMAAVVGGGWWALKAGWVVGGAGQGLVRDFVAVGGLIPLGVLVYGGALWLLRIEGREQLPALWRRLRGQHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQM6</accession>
    <name>A0A139SQM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">AXK12_02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711093.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02550"/>
    <dbReference type="EnsemblBacteria" id="KXU36915">
        <property type="protein sequence ID" value="KXU36915"/>
        <property type="gene ID" value="AXK12_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="29924" checksum="1E01CC197B27ADEB" modified="2016-05-11" version="1">MNITPKDLLDAGVHFGHQTKRWNPRSKPFVFDHRQGISIIDLGKTYEALKKATAFLTDTVANGGNVLFVGTKKQAQDIIREAATSVDMPYCVDRWLGGTLTNYETVKRSIAKFKRYRQMETDGELAKFSSKEEAAIKREMGRMERNFNGILEMEGMPAAMVIVDVQHEKIAVAEAGRRGIPSIGLVDTNSDPAGLTYAIPGNDDAVKSIRIIIETIVEAVQAGLAQRDSRRAARGAADLKAATAAVAAAVGIDTKPTAEPAAEAAEAAAEAAVTAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQQ2</accession>
    <name>A0A139SQQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36878">
        <property type="protein sequence ID" value="KXU36878"/>
        <property type="gene ID" value="AXK12_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="560" mass="60119" checksum="8D70DD97945D638B" modified="2016-05-11" version="1">MLKEELEEDADDFFGEVIISGAQLTLKDGGRLTNAKRFLIKNGGTLFLDNSEAAHSNRLKSTAAVDLYAGTLAFDPGGSGSLTQELGHLTLLGGANQIDLHLGSASGSKFLAEAVSRAANAQTADPFLGRVWPTSTLNIRYIDPPNGSAPTNVDLEVPAGGASAGLIYAISGLSILPWATITHGSQVDWVQWEEGVSSVFKPLTTYYTGSPADWHGQHNVLIDASTAELIFDDPLSGFTQITSLKLANGGALVFGGTSDWNYLTLLSGGLLSTGSAGNQISGRGTISAGNDSPDTFYLHIHANLLVNGSIDLFSGSAPMIKTGEGTLRLTGDVWMQGGSLVINQGTVAFEQGYAMEFRTVSVGDGTGTDVLELPANHSNPITHLDAWWDPENKPTIFLHGTTHSMTPDSGEVDAAILRFGGGTIQHANLLHVEGRGTLDFAGDPDHAPNMFYLEEFTLADFDTTLLFIRHWEDGRDVLLVSHSQENIARINEEFLARIRFEGYTPDEGGATAQWVSWGDGTYWEIRPFPEPANYGALLGALGLGLFAWRRWKRGERAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQV7</accession>
    <name>A0A139SQV7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711095.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02570"/>
    <dbReference type="EnsemblBacteria" id="KXU36917">
        <property type="protein sequence ID" value="KXU36917"/>
        <property type="gene ID" value="AXK12_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="345" mass="38085" checksum="6D64AD085C249E43" modified="2016-05-11" version="1">MSSVFDVLPGVEIPVGEISKRLALMWSPPAPEGGVDPPDDATATQVNFVLHLGLPTTPDEAAAQFQAVLRFTKRYPSRIVILCPQSDTEDKGGLEIRAKIYGKCYFGKTKSDKRCVEVVTFHYSQAARGFLENQVSISLSTDLPLYYWAYRFSASSRLADYRFLLSRAERVLIDSATAPEDALTYPWPNLSALRDLAYARLLPVRQTVGQFLAGYAPEAIVGGLQKITVRHGPDFVAEARVISGWLSERIRACTEGTKVDSTGTHFRRSGQGDTQRSILEPTNSSSLTIEFHYDSADKFFRWTGDFASGQAHFAARLADEPTEARLDASVSLLAPELALSEAMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQX1</accession>
    <name>A0A139SQX1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711111.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02600"/>
    <dbReference type="EnsemblBacteria" id="KXU36933">
        <property type="protein sequence ID" value="KXU36933"/>
        <property type="gene ID" value="AXK12_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="296" mass="32275" checksum="83CFAF91690C9766" modified="2016-05-11" version="1">MKSMTGYGRATAALGGMTLTVQVSSVNRKVLDLSLSLPSAWDALEAELREAVRAVASRGKVHVRVELSRGGDAVGESAAANWDAAAVAATLVRLRALAESHAVPFVPTAELLWRIATAQDSGKTAVSIDDTLTQDIVMATVDDALRAFAAMRAKEGEALLIDFLGRLEQMERLVEAVALRAPEVAPAHREQLLRRLAEAGLELDPGEERVLKEIALYADRCDITEELTRLRSHLDQFSTLLRSAAEIGRKAEFILQEIGREVNTIGAKANDLEIARHVIELKNELDRLREQIANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQX9</accession>
    <name>A0A139SQX9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">tsf</name>
        <name evidence="9" type="ORF">AXK12_02545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711092.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02545"/>
    <dbReference type="EnsemblBacteria" id="KXU36914">
        <property type="protein sequence ID" value="KXU36914"/>
        <property type="gene ID" value="AXK12_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="8">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="197" mass="21364" checksum="66E6765777485FB4" modified="2016-05-11" version="1">MSTQITAKMVNDLRVATGAGLLDCKKALTEANGNTEEAATILRKKGAASAAKKADRATKEGLIESYIHVGGKVGVLIEVNCETDFVARNEDFKTFVKDLCLQIAAASPVCVTREEVPAEDIAKEREIATAQVAGKPPAAVEKIVEGKLDKYYSTVVLLDQPFVKQPEVTIKEKLTALITKIGENIQIRRFTRYQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQY9</accession>
    <name>A0A139SQY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711103.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02625"/>
    <dbReference type="EnsemblBacteria" id="KXU36924">
        <property type="protein sequence ID" value="KXU36924"/>
        <property type="gene ID" value="AXK12_02625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299333" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="775" mass="83846" checksum="6E6ED530EC514AB4" modified="2016-05-11" version="1">MIYRGLALSAVAALASTLAALAQSSPTPHPSSAAAQSTEDQELVTLSVFEVSSAAPARYQSAAAAAGGRIAANIMDTPTTVTVLTQEFINDVGAARVLDVAKYVAGVGEARLPSAQDRLAIRGFEITGRRVDGFSTTDLANYDHGGVERIEVVKGPDALLHPSGAPGGTINLVTKKPQFTPGGSVKVQVGEYNTNRAELDVTGPISQNFAYRAVVAAQDSDGYVSRHTRRSLLITPSLTWRIAPQSNLTLRYEYYDFKATNDVGLPADPSVGTRTPLKTWEGLPRTFNPTYGRHSEFRMAEAHAATALFTSTVTDQLSVRLAGRVAQSSQPYGESRVGTNFETPVPAGWTNRNPLTGEYDPDFIYDPNPPYAPIPAPKMSPIFRLGGTEGPQRHNRYRDLQNDWSYIVDDAEWKSTTLIGFAYAYSATNSDVRPRSVPALDTRVAHYPTGDITRGALTSMRRNAETRYQVYLTEQLQLFNERLVLSGGISHLTFNGYYGDKLWAATATRSAGQMFPGAGSKATHNYGVVVKPIQNLSVYYGHTENAVPVGNFEQVSQGLAPTFSVGEQDEIGLKGSFLEGRIIASIAYYEIEQSGYGIYNPANFSNPPPPTVLPDIIVSRTAEGWEYQVTGSITPSLSIIASYTDATSRDPNGNMLASVPEEMANAYLRYEFLSGPTKGLALAIGATYMGESPIENISGYTPASTPDKLIPNRPSGYLPSRTIVDATISYARANWSYSLTIANALGKDYYAAADFRNLIVPGTPRNLYGSLTWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR17</accession>
    <name>A0A139SR17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711073.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37026">
        <property type="protein sequence ID" value="KXU37026"/>
        <property type="gene ID" value="AXK12_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="462" mass="51675" checksum="8E455733725670AF" modified="2016-05-11" version="1">MNTLFRKVLASFFSPGLFVVLGIAIVTSAIVALTSSDESEGIEIVGFAWQKHAAFVPRVERWNRENPENPFVLKLLSERSLEQRMLSGFLSGTPLADMLDTHEAIFPKAFLGPLENVGFLDLTDRMHDEGLFEQYNEPSLSHVTYQGRVFGLPQDVHPVLLAYRSDIVEAAGIDVSKIETWDDYFSAMRPLLADRDGDGLPDHYALNLSDVAANEIYMLVMQNDGVLFDENDEPAFANERNAYTLAKITTWVTGPERATFYLPYGAAGNQQRLEGLAIGELVIDPTIGMWKLETPGLAGKVKLMPLPAWEKGGRRTSVIGGSMMSINKRSPHIELCWEMTKELYVSAEVAESTWRIAGIISPVKALWNEPFYHEPDPFFSGQSPGTLFIEQAPDVPRRPPSPYSLLARARIGTAAMALRAYADKHEIYDVERLKPEALRLLQHEEAALKKLISRNLLLVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR57</accession>
    <name>A0A139SR57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02485"/>
    <dbReference type="EnsemblBacteria" id="KXU37038">
        <property type="protein sequence ID" value="KXU37038"/>
        <property type="gene ID" value="AXK12_02485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="345" mass="38225" checksum="77ED15E77EB96C49" modified="2016-05-11" version="1">MERFLSAAETQRDRDQAPSALRFDHFMRLALYDAELGYYAQPKRPRVGRHPGTDFYTATSVGQNAANANAASLFGELVAQSCLTLMGEAFCARATFVEIGAERGHGILENLAHPFAASRTLSLGQPLELSRADDAPLIVFSNELFDAQPCRRFVWHQRCNAQNAPAPGWREVYVRAENGALTEVEYPLGRVPKFLPKTAPDGYRIDAALDAKALLDQIAGQAWHGLFLAFDYGKTWAELAEAMPQGSARAYTGHRQTNDLLAQPGQQDLTCHICWDWLQDSLAENSFRDIALDTQEAFFVKHSGAFIAQQIAAEAQNLSPKKQALLQLLHPSHLGQKFQVLSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR60</accession>
    <name>A0A139SR60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711070.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02435"/>
    <dbReference type="EnsemblBacteria" id="KXU37022">
        <property type="protein sequence ID" value="KXU37022"/>
        <property type="gene ID" value="AXK12_02435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="240" mass="25947" checksum="7F5D577E9F94EDE5" modified="2016-05-11" version="1">MTTDSSRTKRFPPQSKLLFLDCDSTLSAIEGIDELARLRGAACFAEIEAMTHAAMEGRIPISEVFGRRLEIIRPTRAECAKVGQMYMECIERGVVEALAAAHAAGWTPCILSAGFREVIEPLAAHLGIEHVEAVGLHFDAAGDYAGYERDHPTTHNGGKPEVIKRWIQQHAPTRTAMVGDGISDLETQPVVDLFVGYGGVVARPRVQAEARAFIRHFDELPALLGGADSAFGAEASPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR72</accession>
    <name>A0A139SR72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000017">
        <property type="protein sequence ID" value="KXU36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711088.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02525"/>
    <dbReference type="EnsemblBacteria" id="KXU36980">
        <property type="protein sequence ID" value="KXU36980"/>
        <property type="gene ID" value="AXK12_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="33347" checksum="A0A4F8377CBBCE18" modified="2016-05-11" version="1">MLPFILRRTLQIAVVLWVIITATFFMIRFVPGGPFTAEKAVTPEILRNLEAHYGLDRPLWQQYLDYMGKLVLHGDLGPSFKYASRSVNEIIADKLPVSLELGALALGVALAVGLPLGLVAAVRRNTLLDYLCSSVAMLGICVPTFVLGPLLVLFFAIKLGWTNASGWYGPGDRVLPALTLGLVYAAYVARLTRGGILEVLGQDYIRTARAKGASAARILWQHALRGGLLPVVSFLGPAIAGILTGSFVIETIFQIPGLGREFVQSAFNRDYTLVLGTVILYATLIVVLNLAVDIAQVWLNPRRKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRC3</accession>
    <name>A0A139SRC3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711077.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02475"/>
    <dbReference type="EnsemblBacteria" id="KXU37030">
        <property type="protein sequence ID" value="KXU37030"/>
        <property type="gene ID" value="AXK12_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="177"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="269" mass="28582" checksum="706EF8AA28EE5CC0" modified="2016-05-11" version="1">MTSTRIHPTALVDPAAELGAGVEVGPFSYVGAGVRLGDGTRLHHHASVEGDTHLGEGCEVFPFCSIGAKTQDLKFKGGRPGVRIGAHNVFREYVSVHAATDDGEFTWIGSHNHILAYCHVAHDCQLGDRIIMSNSVGLAGHVVVEDYAVLGAVCGVHQFCRIGAYAMVSAYAKVVQDIAPFVIADGQPAVIRAINKVGLERRGFAGEPLERVKQLYRILFREGLNRSQALERIAAHPLAASAEFQQMIEFAAKCTRGLASGSAAGAGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRC7</accession>
    <name>A0A139SRC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abortive infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711024.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02175"/>
    <dbReference type="EnsemblBacteria" id="KXU37155">
        <property type="protein sequence ID" value="KXU37155"/>
        <property type="gene ID" value="AXK12_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="197" mass="21466" checksum="3919444950D7674F" modified="2016-05-11" version="1">MSNNPLLLLALIGVALYLAKGWWEDERAANPANPAGRVFKTRAITLAITGSLLLLGCETVGEYALGIVEEQSTITALFALYTLAAAFIEELIFRGYLVITGRGTAARRAGIFAASILFALLHPFLWEWEDAGFQLTLTLKGAFSTAVVLAASLWFYFLRFARCNPQHSLLPCIIAHMTKNLGVIGIKAAQGFLVGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRK8</accession>
    <name>A0A139SRK8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711015.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02130"/>
    <dbReference type="EnsemblBacteria" id="KXU37235">
        <property type="protein sequence ID" value="KXU37235"/>
        <property type="gene ID" value="AXK12_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="175"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="49210" checksum="FCEE27FE619DD2DE" modified="2016-05-11" version="1">MPAAAPPPIATSPRYHIDRPSNFERFPTRLLILTGWCFAETGPAVVSILLRCDNGHSLSTPVALARPEVKAATPTAPSETIGFELRGILEKGQRTLSVFARLEDGSEHLLFTRNTRVCDSLRPLWLRNARAHYDEFFESQASNQARYAPRPISPERFPTHPVKARLRDASPRFAIVTPSYNQALWLPETMASVLDQQPGAQVDYVLQDGGSTDGSVELIRAQADRLHAWESGPDGGQSRAIINGFAKTTGGPDDLMAWLNSDDFYLPGALRYVANYFATHPEVDAVYGHRILVDEHSREISRWWLPSHDHALTLINDPVPQETLFWRRRIWDKVGGLNPDYRYAMDWELILRFQAAGARIVRLPYFLGCFRTHALQKSYAEQESGAIHETLKLRERGFGRPFTPMEFSTHPRLLRHLRRSALTEWLWKRGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRR0</accession>
    <name>A0A139SRR0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">AXK12_02090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711007.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02090"/>
    <dbReference type="EnsemblBacteria" id="KXU37227">
        <property type="protein sequence ID" value="KXU37227"/>
        <property type="gene ID" value="AXK12_02090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="12"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="374"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="485" mass="53149" checksum="EF381F5AEF6F66F5" modified="2016-05-11" version="1">MARKQVTWGGRFAAGPAQLMQRFSESVSFDSRLAPFDIAGSRAHAAMLAHVGLITQKERAAIDAGLEQILGEIEAGEFTWDVALEDVHMNIEQALTQRVPAAAKLHTARSRNDQVATDMRLWFKAACAELDARLAGAQRELFRVAEENATTLIPGYTHLQRAQPVYLAHHLFAWLEMLERDRDRFARVAAQANWCPLGSGAIAGTTLPIDREHTARLLGFVDARGRPQVTQNSMDTVADRDVFIEFASACAIVGVHFSRMAEDLILWSSAEFGFVELPDAFCTGSSLMPQKKNPDSCELLRGKSARLQGNLHTLLTLAKGLPMTYNRDLQEDKPPVFDSFDQVALCADVLAGTVGGLRVNEGECAAAVADPALLATDLADYLVERGVPFREAHHAVGAVVALAEKRAVALDALDTREVCKVHAGFGEDWREVFDLTRALAKRCGTGMPGPEQLRRQLARWKRRLAQPLAQKAAAKPKTGPSKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS33</accession>
    <name>A0A139SS33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme biosynthesis protein HemY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710982.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02005"/>
    <dbReference type="EnsemblBacteria" id="KXU37396">
        <property type="protein sequence ID" value="KXU37396"/>
        <property type="gene ID" value="AXK12_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="110" mass="11695" checksum="9F90AF28719A8B9F" modified="2016-05-11" version="1">MITLTPRAAAQIRLMQEANTATTAADDKQLLRVLVENGGCSGHQYGMSFDAPKDGDTEIESEGVRLLIDADSLAHMSGSRIDFDDGLQGKGFEIQNPNAKSTCGCGKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS60</accession>
    <name>A0A139SS60_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease R</fullName>
            <shortName evidence="1">RNase R</shortName>
            <ecNumber evidence="1">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnr</name>
        <name evidence="4" type="ORF">AXK12_01770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710943.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01770"/>
    <dbReference type="EnsemblBacteria" id="KXU37429">
        <property type="protein sequence ID" value="KXU37429"/>
        <property type="gene ID" value="AXK12_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="742"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="811" mass="89648" checksum="A811757D812DFF9A" modified="2016-05-11" version="1">MKLNERLIALLREAKSRPLSASEIASQLGLPKRERKALSTAIQRLLNAGKLHRSRAGLLSLPASKAARKTESAQHSQPTSTHDELSGEIRFRSGGSAYVVIDSANGAAAGLPASAPAQTIQIAATAAGTALHGDRVALRLIGNTPRRGPQARYAARSKKHRRDSPSERDDELRGEVLRVLSRSRDTLVGELRKNGKHWFVTPDDPRFAREVLVEAPNRIARASRTASFAQNSLTPAPTEGDKVVVRLDAWDTRNAPLTGTLVARLGRTHEPRAELLGVLETYKLSPAFPHEVEAEAAALPAKVRPAELIGRLDYREIPTLTIDPDDAKDFDDALSIEPLPKGRTRVGIHIADVATYVRPDTALDREAQKRGNSTYLVGTVIPMLPEKLSNGLCSLVEGEDRLCKAVFLTFDAQGAILEKDFAATVIRSRKRLTYKQAYALLFTDDLQKVRSLPLPPKHQTGSTGRALSTLPQRELAALQIWVRRLWKIASALRRERMAHGSLDLDMPETKIYVDEQGYADRLERVDNDESHQLIEEFMLAANEAVAQLTRSARLPSLYRVHDDPEPDRLNELRSELATHGLSVGNLAVRAELTRLLAQLATHPQGHLLRSQLLRSLKKACYREKPDGHYGLHKRDYTHFTSPIRRYADLVVHRVLASHLAQKNKHPAGRGEKITGKTLSISTASAGARGGQHIAAHRYTAAVVAALGEHLSQTELNAQAAERESVKIKTLEFFERELAKPVPTHFAAIVTEVRSTGFFIELTESLTFGFLPLANFGKKRKLAARIRAGDPLEVVVHKVDRFRRTIDFRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSD7</accession>
    <name>A0A139SSD7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01855"/>
    <dbReference type="EnsemblBacteria" id="KXU37371">
        <property type="protein sequence ID" value="KXU37371"/>
        <property type="gene ID" value="AXK12_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="326" mass="35986" checksum="C47E38664FC1343B" modified="2016-05-11" version="1">MVTATPLAMFIDAHVHLYPDGINGDPSGWAERAGERHWATLCTRRRKGGQAVQGFPSVDELLRTMDEAGVERAILLSWYWEHLESCRLQNRFYASCIHAYPDRFYAFASVHPGPGGAGESAALAELDWAREHGLCGVGELSPHSVGWAVDDPLLAAVFERAGDWGWPVNLHVTEADSRPYPGKVETPLSDFLTLAERHPRTRFILAHWGANLPLVVTGKLPSNLYFDTAASPLIYGRGKASGAAGRGDPVSSPNESLEGPWRKFVDTVGADRVLFGSDYPLNLYPALNARPEMRRFADEFREQWGLTPDEIRVIGGDNARKLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSI3</accession>
    <name>A0A139SSI3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37431">
        <property type="protein sequence ID" value="KXU37431"/>
        <property type="gene ID" value="AXK12_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="91" mass="9965" checksum="7FA8056AEE015D31" modified="2016-05-11" version="1">MEVRKIAIDNSTLSVLAVGVALFALAFGAFTHLSGRIDSLDAKIEKVSSELNARIDRLDAKIDRVDAKIDVVNARLDRLFELIASPGRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSI8</accession>
    <name>A0A139SSI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710933.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37420">
        <property type="protein sequence ID" value="KXU37420"/>
        <property type="gene ID" value="AXK12_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="283" mass="32262" checksum="A6609892858FCB3F" modified="2016-05-11" version="1">MNDFNGFFDGEWSGDLDDLEWNEFHWERYLREQDEQPHRYLALYEMFLEHPKRTDEVARCMGWAAWNRQDEDSENAHGSTAEAAPEPTANVNAGVKKPSESQAAAQGPESPPVPEHESADALAQRPPSRPTHLPPFSPDDAAPDSDAYYEVYTPQRNPLFIATRALYLRLRRTWELLAQTPDKVSIPLAIRYLATLQRGEDHAMQAIQSMDCGEYALAISLFKRGLAALNESHALLNAADTPAARSYAEEMRVSLFDLRAIWLQVIRECRQEVEDWLDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SST6</accession>
    <name>A0A139SST6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710885.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01460"/>
    <dbReference type="EnsemblBacteria" id="KXU37633">
        <property type="protein sequence ID" value="KXU37633"/>
        <property type="gene ID" value="AXK12_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="58"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="362" mass="37749" checksum="35720D19A502329F" modified="2016-05-11" version="1">MISPDCSPVAVIDIGSNSIKNLIAQRRSANATTSTPEAVEALFSRSIEARISSGADWVKGRSQLAHEAMTAALTAIEALLADCSAYAPAQVALVGTSALRDAANGAEFIDLVRAKTGHSIRILSGAEEAEAIGRGLLCDPTLQSAKTQAQSLYAFDLGGGSLECLALRAGKLVTAQSLPLGSVRLMRRFVKNPEATLAADEREAIRSHVTEAFAHAGFAFGCAPPYADAQPTAIGTGGLWFNVRQMLASELRSPALAAKAGAPAAANASALVAAEPSLAPPFLPRETIEQVLEKAARLPLAERRRLPGISPGRADILPTALTTMLTVLDLGGFSGLQHSTYNLRYGIAAELLATCTGQRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU6</accession>
    <name>A0A139SSU6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710895.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01515"/>
    <dbReference type="EnsemblBacteria" id="KXU37643">
        <property type="protein sequence ID" value="KXU37643"/>
        <property type="gene ID" value="AXK12_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="197" mass="21325" checksum="0A747C0DB9269A38" modified="2016-05-11" version="1">MSTTTPIFPPISEPSFPPPSQGAGATGATAATAAPRPPLNPEKLCSQLGWKVTAARRAIFKAIDKLDGYFDAEVLLVQAKKLHPAVSRATVYRTLPDLCSNGILRSTEFGDGHYRYCRHDPDAPPTAEIYVVDCGRILKVPAPFLSWYAATVTERAGYELIGQRLQTFARCVKKKEDVNACGSCEHQPAAVAPAPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB1</accession>
    <name>A0A139STB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710839.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01230"/>
    <dbReference type="EnsemblBacteria" id="KXU37813">
        <property type="protein sequence ID" value="KXU37813"/>
        <property type="gene ID" value="AXK12_01230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="401" mass="42887" checksum="E283B30531C99E4C" modified="2016-05-11" version="1">MTDTSALPSPAALSIWALNIAPSPTLAVDAKAKSLIAAGEDVCGFAAGEPDFDTPEHIKEAAAKALSEGKTKYAPTPGIPPLREAIAAKYNDFYKIPTEASQVVVSPGGKFSCYLTILATCSPGDEVIIPAPYWVSYPEMVKLAGAVPVPVLATDETGFKLTPAMLEAAITPRTRLLILNSPSNPTGAVYTRAEIEALTAVALRHNLYLMSDEIYEHLLYDGVEHVSPASLSVEARARTIIVSGFAKTYAMTGWRLGTIVAPAPIAKAIAELQSQMTSNATTFAQWGALAAYTQPEKTQAALAVMLEKFDQRRKFLHFELNRIPGIKCLLSQGAFYLFPNVASFGLDDRVFCERLLDEAKVAAVHGSAFGAPGFIRISYATSEMILAKGVGRLAQFCAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STB5</accession>
    <name>A0A139STB5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710842.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01245"/>
    <dbReference type="EnsemblBacteria" id="KXU37816">
        <property type="protein sequence ID" value="KXU37816"/>
        <property type="gene ID" value="AXK12_01245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="447" mass="45807" checksum="AD6C9036E8AC192A" modified="2016-05-11" version="1">MADIIEMPKLSDTMTVGTLVKWLKKEGDSVSNGDMLAEVETDKATMELESFFDGTLLKCFVEAGAQVEIGSPLCAIGEKGETVEAPAPKAPAPAENAQPATAAPATPAAAPITPAAITPTPASSPIVPAPASAAPAAAGSSAAGKLRISPLAKKLAAEKGIDPTRVKGSGPGGRIVRADILAAEKNPAAAAQSAGAAAGARPAKPTWAWRSALDKSAIQAPGIAPLSNMRATIAKRLVESKTQFPHFYLEIEVDAAPLGALREQLNAGLGADGVRLSVNDLILKAAALALRAVPAVNASWSDAGIVSHGATHVSFAVAIDDGLITPVIKDTDRKTVFEISAEAKDLAKRAKAKKLAPAEFTGGTFCVSNLGMMGITRFHAIINPPNAAILAVGATVKKPVVVKDQITIGERMVITLSCDHRVVDGALAAQFMNAVKAHLETPALLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STE7</accession>
    <name>A0A139STE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710860.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01365"/>
    <dbReference type="EnsemblBacteria" id="KXU37835">
        <property type="protein sequence ID" value="KXU37835"/>
        <property type="gene ID" value="AXK12_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="511" mass="57523" checksum="DA9BA198BDEB4F28" modified="2016-05-11" version="1">MISSREKCPTSRRALCFLRLALLVFVLPCALLARPFIVLVYNVENLFDADSQALFRDYQPPHYTRQHVLTKLESITHVVSQFEGGRGPDIILFQEIEVDQTNGEPVPDYDAILRRYAHTTIRDMLGERFDAAVADLPAEALLLKAMADRGMTGYTVVRGEAVQLEPVRALAQKNVTFTRFPVRRAASHPTLNARAILEVEVEVDGARLYLFNNHWKSGAGSLAEEQTRIANARTLRDRLDAILAEDPSADIIVAGDFNSQHNQKQRYPQMGTTALGDVLGSQGDELAIRRRWPRALYNLWFELPPEERASDAYQGEWGTLMQMLLTRGLYDYRGVQYVDNSFGVARLPGVNVSDNGLPKRWSFAGPRGSGFSDHLPIYAKFITVDDGDTERGIWLKNPSANEGIGHVNWVDFSKIDIERVALRLSELGGAAALRDDALKGRIIRVVGRRAAGSRLAVLIDGESFDVWIPEKELRDRLRQRWRAGASVQFYGELGQYGGRWQFVIRDPSWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STQ1</accession>
    <name>A0A139STQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_01410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710868.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01410"/>
    <dbReference type="EnsemblBacteria" id="KXU37840">
        <property type="protein sequence ID" value="KXU37840"/>
        <property type="gene ID" value="AXK12_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="447" mass="47655" checksum="42D7DA6340A6FA0B" modified="2016-05-11" version="1">MPSDSSASLTARYAEVCAYLFGLKATHGLKFGIDRMRSFAAALGNPEAALPLVHVAGTNGKGSVVAMLDSIFRAAGWRVGMYTSPHLVMLGERVQVQRHALRPEEIVAYVDELRPLAERVGGGNAEDCPSFFEFMTAMALLQFGRQRCDIGLVEVGLGGRLDATNIVTPELSIISSIGMDHCEMLGHSLEEIAAEKAGVIKPQVPVVIGRLPAAAEAVVRALAAELAAPVHSVREVFGEGDGRGDWAAYPQTNLEGDYQRWNAATATLAARVLMAQNPRWALTPSCISEGLAQVAWPGRWQRVQVGGRLLILDSSHNPEGAGVLDANLARLVAETGRRPVVIAGVLGAARARPLLETISRHASALHLVVPDQARACSLDELMGLVPPDFRGKVVPDTVAQLFPAAGQCTAGRAEDVLVVTGSIYLIGEVLARLTPPERAPEPRLQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STT2</accession>
    <name>A0A139STT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37975">
        <property type="protein sequence ID" value="KXU37975"/>
        <property type="gene ID" value="AXK12_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="90" mass="9434" checksum="22B27EB204AC6218" modified="2016-05-11" version="1">MHQITINGAQVQTISSQSASSENAARKSGVPEYTCDQRARENAPKFGMQPEPTAQTNKAQAGHISRAPNISATNAVTVTPIAGSAIRDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU19</accession>
    <name>A0A139SU19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710742.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU38055">
        <property type="protein sequence ID" value="KXU38055"/>
        <property type="gene ID" value="AXK12_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU38055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="157" mass="17163" checksum="6908E8F191168BC3" modified="2016-05-11" version="1">MSPFLKWPITALTLIGSIIGAALTLTTFFGMLTRGLSVRALPIFLIAGALYALGLAAGILFAQNDSRRGLIRIYYALQILWLSSPFVSFRFVSGAHFMPAIMGEKLTLSYGFGSVWHIASSGAGPWGLGINLVALTVFWLLRGSRKNGSRKKRTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH80</accession>
    <name>A0A139SH80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_08405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="LSZP01000063">
        <property type="protein sequence ID" value="KXU33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713369.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08405"/>
    <dbReference type="EnsemblBacteria" id="KXU33917">
        <property type="protein sequence ID" value="KXU33917"/>
        <property type="gene ID" value="AXK12_08405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="4">
        <location>
            <begin position="4"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="325" mass="35866" checksum="D9D4CDBFF6A1C0C5" modified="2016-05-11" version="1">MRAFITGITGQDGSYLAELLLGKGYEVHGLVHRPDALAASNIAHLVRDNTLLGKRLFLHNGAFEDATHLRRIISKAQPDELYHLAGQSSPRLSLELPESTVDSIGMATLRLLEILRDLPKPTKFLYASSSEVFGSPSHSPQDEHTPLKPTTPYGAAKAFSQQMARIYRTAYGLPTCAAILYNHESPRRSTSFVTMKIARAVARIKHGLQDSLTLGSLEGHRDWGWAPDYVRGLWLMLQQPTVDDYVLATGQLHSVKDLVKVAFAEVALNWRDYVRYDDALLTASVEPIASCGNPTKARAALGWQNTVPFPEIVARLVQSELAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH87</accession>
    <name>A0A139SH87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000065">
        <property type="protein sequence ID" value="KXU33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713381.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00615"/>
    <dbReference type="EnsemblBacteria" id="KXU33903">
        <property type="protein sequence ID" value="KXU33903"/>
        <property type="gene ID" value="AXK12_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="14767" checksum="A2D647F0D172BCE9" modified="2016-05-11" version="1">MIKLTDHMKAILAQQLPIQATCSKDGLPDIGPKRSLRTYDDSTLIYNENTAGQTLQNIRDGSKIAVAVIAREALEGYRFVGRPEVFSEGEPFEQAVAYAEEKGYKPPKFAVLVHIEDIYTLAPGPTTAGKKVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHC8</accession>
    <name>A0A139SHC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713233.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU33982">
        <property type="protein sequence ID" value="KXU33982"/>
        <property type="gene ID" value="AXK12_08060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="388" mass="42969" checksum="ABAE32A63BF80D06" modified="2016-05-11" version="1">MNLLDPTPSKVRKGNDRDGERGLMPDFVRGGRDRSVQIGIVGTILIHLLFILVAPHLLRFEHDGSLGTRAEREAMQEFNIELEDELAEQLAQAEEPPEPFNFVEVNPEAPENEPDSVVNFGAQNQQTAQLEESEDTSGDRPFLEGQTEIQTNQIVSGELTEQPLLPPELSAPPPPEAQEEATDEEQREAARKEEIPLSGFEKITGEDSDGYGANLAELPDGSAEFEEYVEGVKDAASTLGPPGRLRIDPNRPLPRPRLEPQQLRARPAIFTENLAGTANIGPTAIDARWSDYGQYLQQLIETVQIQWDRILIQSRIYPGSGTNVSVKFVLNERGEVARIVSVEGSSGEIGKQSCVSAITARAPYGEWSDDMKRVLGAEQEMTFTFYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHE0</accession>
    <name>A0A139SHE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713245.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08090"/>
    <dbReference type="EnsemblBacteria" id="KXU33988">
        <property type="protein sequence ID" value="KXU33988"/>
        <property type="gene ID" value="AXK12_08090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="830" mass="89033" checksum="4036E698EE20D310" modified="2016-05-11" version="1">MIKGTTALLLGLFMTRSCRSPVAALTRAFLLLSLLTIGPVASLNAQTLSTSREVNFYRDIPSRSLKGLAARSDGVLLNGPHIRPLDLVLSEQGADLLWSAVSIGQTVYLGTGPEGLILSLEVSDDGVTLKPSETISLPHDSHLLALAALPDGELLVGSSPEGALSLIKGGEVIARTALPVSSILAIDVNATYEGNEYALVATGSPARVYRVDLAHFRKSGRRIEKLDDDADALAECGIELWGAVRDEAIRSLLRLPDGRVIAGSAPKGNLYEFKESGGEPRVLSENTNTEVTSLLAWEGGFFAALTTGDTGRRTAQLARNSANNVRPTPTRDSANNSGGGEGAGNDSGDGEPSNEGEQGAPRSPQRPALRTAPTPKFSGSSRLLWFPDGGYPEVAGARQGVGFYQIARHGDLVLITAGDEGELLGYDPKNRLGMVFAGATAAQVNGILPLPPTQVSSATAGVRSTPNKTLPERFLLIGNNPASLELMDFSAAAERSATTRRIDLGSPAEIGALRFPELSDASSASLQVGLRTSESSDPLEGWGHWEPTAESPFDMGGYRAEHGPLRGRYVQFRFTAAGPDAPLFEAESPRLYLLPQNQRPQLTKFAVLPLSNARNGTDTLRKLAESTPSIGYREDLAAASSTPLHRRTRVIVWDLSDPNDDALLSTLSIRGPSDTDWQPVLVDSTQRYAVFNTDGMKEGRYRTKLEVRETAPRPVEQRLSVSFEGESFVIDHSPPEILTREILRTADGGLSISLVAQDLDSLLLGAEIRLNNGNRYEFTQTLDGILDGKRETFVIELNTEEVGSSSFLEATVIDTHYNATTQRLPIPIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHG2</accession>
    <name>A0A139SHG2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_08190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34005">
        <property type="protein sequence ID" value="KXU34005"/>
        <property type="gene ID" value="AXK12_08190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011276">
        <property type="entry name" value="TonB_haem/Hb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01785">
        <property type="entry name" value="TonB-hemin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299228" evidence="5">
        <location>
            <begin position="21"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="65"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="287"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="701" mass="76103" checksum="2C29DD45EB787D10" modified="2016-05-11" version="1">MRCRSSIHGFALAASLLAVAVAAFVAPLTRGVSQTGIGSRDAADDTLINLDAITVSSTRTAWRAFDVPGMTSVVDSRALDLLQPQSMDEILRSLPNVELFGGPRRTAEVPRIRGRNSENILILIDGMRQNYSGAHRGRYFIEPDLLKSVEIVRGPNSALYGSGAQGGILSMETKTASDLLLPGQRYGSRLKTGYVSANDERFFGAAAYGSTGTVDLLASVTHREGGDIRLGTGEKLEFSGSELRAAMFKATWHIAPGQSLSLVHDTAREENIQPTNPQGNILSSIVNRKTKVEGSRARYVLHPAQSDWVDLEAVAYRVTTGNRDLGVSAGLLDRDERRSVRTTGFNLINRSRFEAAWLGTHRLAYGVDFFGDENVARRFDTGAGLPIQTSPEGDVDYAAVFLQDEIGLPGGVTLIPGLRYDRFKSKAIGENFASSDDDVSLKLGAVWRPLPEFFVFGLYSEGFLTPDVAQIFRSGRHFRIGARQQDFVPSLGLKPESARNYEGGLGFERKLASGARLQTKLSLFHQDSRDTISREVVILPVPAELAAIGITQYEQSRAANLEGAAFRGAELEFGYTTETWFVNGGASTLRSKVDGTGLKLSTTPADKLSLSGGRRFADARLTLGGSALFVGNRRSKVEEPQYQTHGYADFGLSAAWQPSIAYPDTTLNLTASNLFDKAYARDDVGRFATGRSVQATLTVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHH5</accession>
    <name>A0A139SHH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_08370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713338.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08370"/>
    <dbReference type="EnsemblBacteria" id="KXU34032">
        <property type="protein sequence ID" value="KXU34032"/>
        <property type="gene ID" value="AXK12_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="218" mass="24042" checksum="DF25D0695990B8E6" modified="2016-05-11" version="1">MSKLFPKSANKLPLQIVIYLFVLGGIATAGVSYYMTPSYTRIGYAPTQPVPFSHALHAGQLGLDCRYCHVGVDKGPASTIPTAQTCMNCHNQVKLDSPLLAVVRESYETGDPVPWVKVHQVPDYVYFNHSAHITRGVSCVECHGRVDQMDTVTHAKSLSMSFCLDCHRNPEAAVRPLDKVTDLAWEHPEGKAGQLRDGAKFVHDWNVKPPQSCSGCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHK1</accession>
    <name>A0A139SHK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_08350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713330.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08350"/>
    <dbReference type="EnsemblBacteria" id="KXU34029">
        <property type="protein sequence ID" value="KXU34029"/>
        <property type="gene ID" value="AXK12_08350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="217" mass="23480" checksum="B38FAB3BE197C734" modified="2016-05-11" version="1">MRNVYLVTALAVVLLVSVLGLRGTVFTAPPMDVFPEWAFPGMKRQSKYKPQASSKLFADGRADRPLPAGVVAANYGPLGRPLQSDSHLLSGKLADGSFARGFPESIEVNRQFLEQGRERYSIYCAPCHGALGDGNGITKSYGMGATPTYHDERLREIAEGEILNTILHGKGNMLSYADKLTIEESWAVIAYVRALQLAQHASPADVPAAHKPSLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHK2</accession>
    <name>A0A139SHK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713298.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34013">
        <property type="protein sequence ID" value="KXU34013"/>
        <property type="gene ID" value="AXK12_08260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="105" mass="10969" checksum="18AA1884F2039C35" modified="2016-05-11" version="1">MSTPANASSGPLRATWICLALGWVFFLLPIPGLSISGGIALCFVAFILSIVVLAQGNISGGLITLLLTIVASPIVYAIGWGIFALLVQKGMMDLHGQDYGLTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHK7</accession>
    <name>A0A139SHK7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_08335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713324.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08335"/>
    <dbReference type="EnsemblBacteria" id="KXU34026">
        <property type="protein sequence ID" value="KXU34026"/>
        <property type="gene ID" value="AXK12_08335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045278">
        <property type="term" value="C:plasma membrane respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004677">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF29">
        <property type="entry name" value="PTHR10422:SF29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="3">
        <location>
            <begin position="182"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="473" mass="50865" checksum="BDB7329B1562C9A2" modified="2016-05-11" version="1">MTTSSSPALAEVSDLDRSARWPLAFLILASLGWLVFSGFTALLNTLQVLEPRLLADCEWFIYGRLQAIQESAFLYGWAVNAALAVGLWLLVRLGGAPLRAANWVAVGALFWNLGLTLGLGGIAAGHMTSFALFQLPDYIQPLMLAAFAAMAAPGVLAWTGRRERPTFASQWYVVAALFLFPWAFSVAQVMLLFAPVRGVLQPIIATWFGQNFLGLFLAPIAIAVLYYLLPKIKGQVLPAYDFAPYGFWALLLFASWTGGRHLIGGPVPAWLPTTAIAAASMLLFHHLILALNLRGLFAPGGSLALKFAAGGLAAYLLSGLSDAVFSMRGLSVITHFTYFEQAQSQLFLGAFSLSIFAAIYTLAPRLLGIVWPSVTLIRAHFLASFIGIPVLVLVLALAGWQQGVALADAEIPLRTIAANTRPWLQVAAAAQAVLLFGNLTFLVHFAGLLCFSRRGGASIAQFRQLQALEATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHP3</accession>
    <name>A0A139SHP3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kbl</name>
        <name evidence="3" type="ORF">AXK12_08165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713267.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08165"/>
    <dbReference type="EnsemblBacteria" id="KXU34000">
        <property type="protein sequence ID" value="KXU34000"/>
        <property type="gene ID" value="AXK12_08165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="415" mass="44414" checksum="D7F3B16634AFFFAD" modified="2016-05-11" version="1">MLSPEFKTQVSATLAEIDTAGTTKRERLITTPQAAQVQVAPPYGTMLGATKSSASSDTPHALLNLCANNYLGLANHPELVAAAHAALDRWGYGLASVRFICGTQTLHRDLEAALSHYLGMEDTILYASCFDANGGLFETLLGPEDAILSDALNHASIIDGVRLCRARRYRYQNNDLADLEAKLREADANGARHKLIATDGVFSMDGTIADLRGICDLAERYGALVMVDDSHAVGVIGANGRGTPEHCGVEGRVDILTGTLGKALGGASGGYTSARREIVELLRQRSRPYLFSNTLPPVVAAASLKALELLTRSGELRARLAENTRFFREQLSAAGFTLLPGTHPITPVMLGDAALAQRFADRLLGKGIYVVGFSYPVVPLGKARIRVQVSAVHSRDELAHAVQKFTETKAELGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHQ8</accession>
    <name>A0A139SHQ8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_08270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08270"/>
    <dbReference type="EnsemblBacteria" id="KXU34014">
        <property type="protein sequence ID" value="KXU34014"/>
        <property type="gene ID" value="AXK12_08270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299232" description="Peptidase_S11 domain-containing protein" evidence="9">
        <location>
            <begin position="38"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="57"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="338" mass="35952" checksum="A3C6DBBEA841B37A" modified="2016-05-11" version="1">MAFPTWLQPFLSRLSRLVCGSLILAATAIISAPLAYAADAAKPKSLPQAAATTPPYKAAIIIDAASGAVLFDHDADRIAPLASVTKLMTFLLVHDAIERGQLQLDSPIRITAASARIGGTQVWLREGEVFPVEELLYALMLHSANDCAHALALAVGGSIEAFSEMMNTRAAELGLTLTRFHNPHGLPPSGGTKSNIADGNLSTARNIATLSRYLVTHTDILKYSSTQQRRFRANDPQRRVDMRNHNHLLGKVAGVDGLKTGYTRSAGFCLAATAARSSQRIIAVILGAPASKTRDLAMVELLERGFAALADGAALRAQAAKTAHDAEGHIQFTIPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHS3</accession>
    <name>A0A139SHS3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_08355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713332.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08355"/>
    <dbReference type="EnsemblBacteria" id="KXU34030">
        <property type="protein sequence ID" value="KXU34030"/>
        <property type="gene ID" value="AXK12_08355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="19218" checksum="CFCBC63FADE3439D" modified="2016-05-11" version="1">MSEQPYGLIATFDTAAGLYHAAEQVRDAGYKNWDCITPCPVHGLDGAMGLGRSRVPRISLCGGLLGFTTGMSLIYWSGAVNYPLIVGGKPLFSPMFAFPVSYELTILFTAFATIIGMFVLNGLPRHYHPVLKDDVILRGLDDKFLIVIEAGDPRFDAIHTRALLENIGGTGIKELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHS9</accession>
    <name>A0A139SHS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">AXK12_07970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713208.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07970"/>
    <dbReference type="EnsemblBacteria" id="KXU34107">
        <property type="protein sequence ID" value="KXU34107"/>
        <property type="gene ID" value="AXK12_07970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="177"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="332" mass="35813" checksum="85B0D7ED22996585" modified="2016-05-11" version="1">MTWTRRHLLCLEDLSLAEIDHIHATAAAFKRSLQASESAAAPRSLKGKTIVNLFLEPSTRTRMAFEIASKRLGADTVSLEGKSSSTTKGETLRDTAENIQAMQADAIVIRHAAAGSPLYLSKILNIPIINAGDGAHAHPTQGLLDTFTMREHFSGRSSASSHAENNGEILLAPDLRGRRVVILGDILFSRVARSNIHALRTLGADVTIVGPSTLVPPYFAALGVRVSHDLRRALADAEVVMLLRIQHERQSRSLFPSLGEYTSLFGLNKTRASWLHPNAIIMHPGPINRGVEIDSDLADGPHSVILNQVTNGVAIRMAVLHLCLGGQPLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHW8</accession>
    <name>A0A139SHW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_07760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713131.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07760"/>
    <dbReference type="EnsemblBacteria" id="KXU34168">
        <property type="protein sequence ID" value="KXU34168"/>
        <property type="gene ID" value="AXK12_07760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="271" mass="28771" checksum="9426C7AA50503AAE" modified="2016-05-11" version="1">MLAEWGLGEWVLAAACAFIIGVSKTGIAGLGMLGIVLFANLMPAKLSSGFVLPMLIMGDCVAVAAYRKDAQWAMLLKLFPWTGLGVVCGYFAMGHLTNAQAGAFIGTIILVFIAVHLIRQGTKPRSSGGTRVGGPSALRKATATADQKTHGTGFVATFGIMAGFTTLVANAAGPIMAIYLLAMRLPKLQFMGTAAYFYLLMNCFKVPFMVDLGLINWESAKGNLILAPAVFVGTLIGRVVLQKMKQQLFEMIALVLSVVAGLNLLYRSWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI44</accession>
    <name>A0A139SI44_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_07925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07925"/>
    <dbReference type="EnsemblBacteria" id="KXU34191">
        <property type="protein sequence ID" value="KXU34191"/>
        <property type="gene ID" value="AXK12_07925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="585"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="816" mass="89120" checksum="6E252F074565B335" modified="2016-05-11" version="1">MSFTNHIKTLLGLRRQRRRAEPAAFMAFLEGSRLVTALIFFTTVAAIVAISSAGLNTAHLPVLQGQVATVRIAAALPFTYESALRTASAQAQVLERVPPVYRLDTAELKKFSTALRELHTHALELDAHSVPLPLPQPEDALDDTDDPSSDERLANHPQTERVEDSELARAFSAFRAAGPYRASFEDFKILLSQVPDPTTRSALIEVGLEILAQIYADGVHDNSLLPGTASGELPLIQVASPGSSSGSESAAVAPRRIQSQEEALSYLRLNLSGEDVPRAAQVALFRLLRHGVSPNLVFDREATAARQRAILANLKPVQIEVSRGETIIEPDTRVSPEQYEMLMAHRQALRASGTGETDERMQLFGRVLLVLAMVLASVFYVRLEDRETFQSNGRLGLLALVVILNIALVRLVFSLAEMDFFAANSDWASTLPYIAPSAFAPLILAILIDAGSAIFMALFISIFTGLIYGNRLDLLVVTFLASTVAIFSCQDLRRRSRVVRAAGFGGLAIALFALLVGFSEQLPAATLLKQFGVGLASGVSTGILVVGLLPIFETLFKRTTNITLLELTDYNHPLLRKMQIEAPGTYHHSLMVAQLSESAATAIGANGLLARVCALYHDIGKTVMPEYFIENQRGGENPHDENNPSLSALIIKSHVKEGVDIARKHHLPRPIIDVIREHHGTSLIRYFYHRECVRAQSNNGHAATANTPTLPGIAPAEVAESTYRYDGPLPRTKESAIISLADGIEAASRSLRQLSPQHINELIDSVITERVETNQLDESSLTFAELSTVKESFSHTMINMLHSRIEYPKPNDGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI48</accession>
    <name>A0A139SI48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07840"/>
    <dbReference type="EnsemblBacteria" id="KXU34203">
        <property type="protein sequence ID" value="KXU34203"/>
        <property type="gene ID" value="AXK12_07840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299269" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="199" mass="21315" checksum="A97683A46478DCF7" modified="2016-05-11" version="1">MKTLISLLAASLGLASLASARVEIGAAAPDFTLTDIDGHTHRLSDYRGKTVILEWVNPECPFVVKHYESGNLPKTQEAATAEGVVWLLINSAHPEAQGDYSADEARAWQASTGAAASAYLRDPDGTVGRLYDAKTTPHLFIITADGSLAYDGAIDSIRSTRQSDIEKAENYVTSALDALRRGEPVATTVTLPYGCTIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI96</accession>
    <name>A0A139SI96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713191.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34200">
        <property type="protein sequence ID" value="KXU34200"/>
        <property type="gene ID" value="AXK12_07720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="349" mass="37136" checksum="CA2A7232931A3CDD" modified="2016-05-11" version="1">MKILMVGAGGQGKGHSARYQQMPGVEVVAAVDVQAELLAAFAKEYKIPNTFSSVEEAIAWGQFDAVSNVTPDRFHYPTTLPLLAAGKHVLCEKPLATNAADAVKMAEAAAKAGVVNAVNFSYRSGGAMQKAAELVRSGLIGEVRFFEASYLQSWLHQPAWGEWTTTPQWLWRLSSAHGSKGALGDVGVHIVDFATYVMDLPVADVSCRFALHNKAPGNKIGEYVLDANDSATMQVSLANGALGTISQTRVASGHLNDLRLKAYGTKGALEVSTSGELGTLTACLEADLEKPKWQSIEVAPVTDNQARFIAAIRGEDGPRAPDFARGAEIQKVLDAAEESAAQRGITINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC3</accession>
    <name>A0A139SIC3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DsbC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713055.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07585"/>
    <dbReference type="EnsemblBacteria" id="KXU34328">
        <property type="protein sequence ID" value="KXU34328"/>
        <property type="gene ID" value="AXK12_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02953">
        <property type="entry name" value="DsbDgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035671">
        <property type="entry name" value="DsbD_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299260" description="DsbC domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="4">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="709" mass="75408" checksum="40A33F979A99D5E8" modified="2016-05-11" version="1">MPAVTFLRLLSLLVFALAGSVFSTTTALAQVRASLIAEVEHIQPGQPFYAALRLEHQGHWHTYWVNPGTGLATSIEWELPEGFTAGEIEWPAPTVLRDRQGEIIGNGYEGEVLLPVKITPPENLERGSRVTLHAAADWLMCDEVCIPGGAALELVLRVAQPGADNVRLSGWESQIRKAIAELPKLPDEWQVSAVRSGDTITLTVLPTANAGDVSPVRPQWFFAEDNLVGYDLPQQIAPAPDGRGGYILALTVSPEMREESVERLTGVLLAEDSWLADSSLPGLRIDVPLEKAAAASGSLVGMSSSVSSAGLFATAALAFLGGLILNLMPCVFPVLGIKILGFVNQAGSEKRKVVAHGLVFTLGVLLSFWTLAGVLAVLRAGGEQLGWGFQLQSPQFVFGLAVLLLVFAMNLSGAFEFGLGATGLGAGLQTKSGLSGSFFTGVLATVVATPCSAPFLAPALGAALAMPVSESFLIFTAIAIGLSTPYLLLSIFPKAVGVLPRPGAWMETFKQFMAFPLYATVGYLLWVLAGQASENALLLIFFGLVVIALGLWCYGRLQAPGASAGRARAGLLGGAALLACGLWLGWPQAPAPTEVVWEPWSEELVAKYQREGRPIYLDFTARWCATCQTNKKLVFSSGEVLKTFADKNVAALKADWTSKDPKITAALAKYQKSAIPFNLVYLPGEPSPRELPSLLTPGIVLEALKRGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIF6</accession>
    <name>A0A139SIF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713027.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07505"/>
    <dbReference type="EnsemblBacteria" id="KXU34313">
        <property type="protein sequence ID" value="KXU34313"/>
        <property type="gene ID" value="AXK12_07505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="229" mass="24296" checksum="910E43E56F1D325E" modified="2016-05-11" version="1">MKILITGVSRGLGRALTEFYIAAGHTVFGCGRSGAEIFELRMAYPDHHFAVVDIALENKVALWAADVLGSHGAPDLLINNAGGMCRSAPLWAQSDEAFTRLLDGNVRGVANVIRHFVPPMVERKSGVIVAFSSGWGRTVAAGVAPYCATKWAIEGLTRAMAAELPEGMAAVTLDPGIIDTEMLRSCWGEGAGEYPPPAEWAKAAAPFILKISPKDNGQPLTLPGAKDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM1</accession>
    <name>A0A139SIM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="10" type="ORF">AXK12_07680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713086.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07680"/>
    <dbReference type="EnsemblBacteria" id="KXU34344">
        <property type="protein sequence ID" value="KXU34344"/>
        <property type="gene ID" value="AXK12_07680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="25197" checksum="1CD569CE61D1A52B" modified="2016-05-11" version="1">MSSAPCELILALDAPRPADIAPALRQLQGTVLWAKVGLEMFTACGPDCVREIADLGYRVFLDLKLHDIPNTVARAVTSVASLPIGMLTLHTSGGREMMQWAARARAEHAPELLLLGVTVLTSTSASSLHETGVAASPADQVRRLGSLAVEAGLGGLVCSPLEIALLRTALAPSVTLVTPGIRPSGTATDDQARILTPAQAAAAGANFLVVGRPIFNAPDPVAAAKLIAQEAAHASSAKLSSHAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN6</accession>
    <name>A0A139SIN6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712883.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00390"/>
    <dbReference type="EnsemblBacteria" id="KXU34409">
        <property type="protein sequence ID" value="KXU34409"/>
        <property type="gene ID" value="AXK12_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8115" checksum="4B4F8A89F3BA68B3" modified="2016-05-11" version="1">MKLKFKTQAYQTAAVQAVVDCFKGQVPYHGGIRYRLDGGTRKAAPTSPQGALALEAAPEFGRSQILFFQKSDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIN8</accession>
    <name>A0A139SIN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34417">
        <property type="protein sequence ID" value="KXU34417"/>
        <property type="gene ID" value="AXK12_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="69" mass="7874" checksum="56AB6DDD574977A1" modified="2016-05-11" version="1">MGLARDRRRTLRNPGFVSFMLDNNRRRLGGNAHERALLWRRWLRGSALALLVIGIAWVAIESAKALSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIU5</accession>
    <name>A0A139SIU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712893.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00425"/>
    <dbReference type="EnsemblBacteria" id="KXU34414">
        <property type="protein sequence ID" value="KXU34414"/>
        <property type="gene ID" value="AXK12_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="266" mass="28475" checksum="1068CA90A3CDB186" modified="2016-05-11" version="1">MSPIATLFRSSIGRKFLMALSGIVLVGFAIGHLVGNLQIFSHPDHLNGYAEFLHNTGPMLWVVRAVMLLSLGVHVWAATVLTLENKRARGGQAYAAGKNWLRAPFASRYIRLTGYVVLAFVLYHLAHFTLGVTNPADFKGAHAYVMQGDYAVAGLPVVAAGTQVDNVYLMVYRGFESVPVSLFYIVAVGLLSLHLLHGIDSLFQTLGLRSQTWAGALRKIVALVCLLYFIGNVAIPGAILTGALAPHPAAEVYSVSATATAASAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIW8</accession>
    <name>A0A139SIW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712905.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00460"/>
    <dbReference type="EnsemblBacteria" id="KXU34420">
        <property type="protein sequence ID" value="KXU34420"/>
        <property type="gene ID" value="AXK12_00460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="527" mass="59333" checksum="B28329132AEB4475" modified="2016-05-11" version="1">MISEKLRNRIGLVALALALLASFGTVATRNVQSLTNDKIEIRVAHSELHTGMREAFEAAIVAYEALHPEVRIVQVSVPSRIYPAWSRTQLVSGTAPDIMPLAGTDIEIVQFFQPITTLTSAPNPYNEGTPLEGVAWRDTFFDGLSGLSDSMRWTAPNEIFGVILQTTSMRLYINRDLLLEITGTDALPRSYAELHALAEKVRAYNQSHGAHLIPIASCKAYAEYIFDRIVGSQMQRFLVDYSFHMKSWGFYRPMYDGKYSYSKTPEFVSSLELMSEVAQMLSPGFQQFAPEDAIATYLQQRSLMLVAGSWDYAVLVDQVSFETEVTPLPMPTTDDPKYGKFTLGQAAEDVRTTAALGIVRTSPNTEIAIDFLKFLTSHPVATQFSEMSQRISTIIDVPVPDALKKMAPQIEGEIPGFRVDNFLGNNNVRNLIQRHIHKVIGPSPDISGFAETIDAELAPNIREDLKYYHRYDRLNTQRFDATIALHYIFPEEHEQAARTNWQLHTEAQHGSQSRYIEYQHYLEPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIX4</accession>
    <name>A0A139SIX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ORF">AXK12_00585</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712955.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00585"/>
    <dbReference type="EnsemblBacteria" id="KXU34444">
        <property type="protein sequence ID" value="KXU34444"/>
        <property type="gene ID" value="AXK12_00585"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="371" mass="39884" checksum="184CF99FB9135695" modified="2016-05-11" version="1">MPKNETTLKFSVLAGDYIGPEVMRSALRVLEKVAAQEGLKLDYSEHAVGGCAIDAHGTALPEATLTACEAADAILFGSVGGPKWESLPPKEQPERAALLPLRKHFTLFANIRPGLLYPELREASPLKNERIPEGIDIVCIRELTGGIYFGQPKRTTLLNGGTDVESVDTMIYRKSEIERITEVAITAARSRKRRLCSVDKANVLETSVLWRKTVSDYVAANAPDIELSHMLVDNAAMQLVRDPGQFDVFVTENMFGDILSDEMAVICGSLGMLSSASLGARKNTLGLPYGLYEPAGGTAPDIAGKGIANPCAQILSGALMLRYSFGLEDAATRIERAVREVVASGTRTGDIAFGRTAVGTEQMTEKILGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIY7</accession>
    <name>A0A139SIY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">AXK12_07125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712796.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07125"/>
    <dbReference type="EnsemblBacteria" id="KXU34517">
        <property type="protein sequence ID" value="KXU34517"/>
        <property type="gene ID" value="AXK12_07125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="316" mass="34113" checksum="E91E2A212D323724" modified="2016-05-11" version="1">MSESRLKILSGNSNRALAEAICRSIGEPLGEATVTSFPDGESFVKINENIRGNDVYIVQATCPPTNHHLMELLIMIDAARRASAKRITAVLPFYGYARQDRKDQPRVPITAKLVANLLVAAGAQRILTMDLHSQQIQGFFDIPVDHLYASPVFFEYLAEQPRERPLVVCSPDIGGMKMAAAYADTMGATLGMVAKKRKSASSVEAMSIVGEVEGCDVLLVDDMTETAGTLTAAAKILRDHGAVTVRAAVSHCILNDIAVERLKAGLIDEVITTDSTPVQTHGLPIRVLSVASLLGEAILRITNNKSVTDLFKIKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIY9</accession>
    <name>A0A139SIY9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">AXK12_07265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712848.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07265"/>
    <dbReference type="EnsemblBacteria" id="KXU34542">
        <property type="protein sequence ID" value="KXU34542"/>
        <property type="gene ID" value="AXK12_07265"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="40916" checksum="3E2EE71EAD6A2B20" modified="2016-05-11" version="1">MLSYLANFEEYFGPLRLLRYITVRAFFGAGTALVIGFLVGPWFIRKFRALKVGQHYDDDRTGDIATRFDKKNTPTMGGLIIFLSVFTSALLWATPNVWVLVALFVYAALTVAGFRDDYLKVVHRNRAGISSREKLLWQSLVTLIALGLLLCHPLSAAKVRELWVPFFKTAVIAQMPWWLLLALIYLWVVGFSNAINLTDGLDGLAVGCTITVALVFAIMAYAAGNVRISDYLLISYVPGVGELAVLCSALIGACMAFLWYNSHPAEVFMGDTGSLALGGLIGVMAFMIHQPVTLIIVGGIFVMEALSVIMQVGWFKYTRARGGVGQRLFLMSPIHHHFQKLGWPESKVVLRFWVLSLGFALAGLATLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ01</accession>
    <name>A0A139SJ01_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ORF">AXK12_07290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07290"/>
    <dbReference type="EnsemblBacteria" id="KXU34552">
        <property type="protein sequence ID" value="KXU34552"/>
        <property type="gene ID" value="AXK12_07290"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="529"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KXU34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="827" mass="87401" checksum="F953919A68AE49F7" modified="2016-05-11" version="1">MTTAALPTLFGKTAVRIHCVGVAGMGLGPLAVYLSRSGWQVSGEDDSLDAAAAETGPGAPAAAELRERLLESGVRLEPLPEACDLVVTSSAVLQSHPTVLAARQRGLSIVRRGELLAEVVKDKRLVAVCGSHGKTTTTAMLASALRASGALSTGLAGEPPPLSFGFILGGLPARREFPLAQVAGAEGAWVVAEVDESDGTIEHFTPEITLCVNLDWDHVDHYPSEDALRATFGALFAKTRRAVLINAACPLSQTLAAETAAVPVFRFGDRRDGAVGEGGANPVGEGGGFTGEITAEGGDSLRLALGGRFEIASAELRASGRFNALNATAALAAVQLMGAQLHTHLLAKFPGVRRRQTRLSDLGGLRVIEDYAHHPAEIRALLAELRRDAGKRLYVCFQPHRYSRTAQFKRELAEALSSADHVFLIDVYGAGESPVEGGTTADLAREFAEGGATYCRSDEALLAALGRTVAQASCVAFVGAGNIDAKARAWLALWRARFWDEFAQELRGVVSAETKLTREEPLARKTTMLVGGAARVYAEPRSVEELQRVLRSAHARGVPVFPIGRGSNLIVPDEGVEGLVISLSAPEWAKFEVREDGRIYVSAGLRLKNLCGLAAKAGIAGFEFLEGIPGSVGGALRMNAGAMGAWIFDAVELLEFITLAGEVVTRRVDELHVGYRHCAELAEGAIALGALLRSGAQVDTEAVARQIDVYRKKRVESQPREPSAGCIFKNPEGDSAGRLIDSAGLKGLRVGGAEVSAVHANFIVNRDHATASEVLELVAQVQARVLAAHGVALEPEARLFGKDWSEVAELSDLASASSSTRQKGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV0</accession>
    <name>A0A139SJV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">AXK12_06825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712688.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06825"/>
    <dbReference type="EnsemblBacteria" id="KXU34797">
        <property type="protein sequence ID" value="KXU34797"/>
        <property type="gene ID" value="AXK12_06825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="200" mass="21692" checksum="9021855CAF956760" modified="2016-05-11" version="1">MSHTPTLKTLYAEQVVPALTKARGYTNKHEVPTIQKVVLNTGIDADADKTQISDIQRDLGLIAGQRPVLTKAKKAISNFKLRQGQVVGCCVTLRGNAMWDFLYRLIAVALPTIRDFRGISPKLDGNGNYNLGIADLTIFPEITVENVKKTMGLDITIVTTATDDEEGRELLRLLGMPFRRVAAAAATTTAAADEPQAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ6</accession>
    <name>A0A139SJZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_06905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712714.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06905"/>
    <dbReference type="EnsemblBacteria" id="KXU34810">
        <property type="protein sequence ID" value="KXU34810"/>
        <property type="gene ID" value="AXK12_06905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="283"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="428" mass="46659" checksum="5A65EC4DF5E137C9" modified="2016-05-11" version="1">MSSKSLPFTREQLEAISAQVPTPFHLYDEAAIRANARAFYAAFDWVPGGFKNYYAVKALPNPYILDMLKSEGMGGDCSSLAELKLCAAVGITGESIIFTSNDTPAHEYREAAALGAIINLDDISHIPFLEDALGGQLPEILCCRYNPGPLKAGNAIIGKPEEAKYGFTREQLFEGYRLLQQKGVRRFGLHTMVASNELNPEYFVETAQMLFTLAVELHRELGLQLEFINLGGGIGIPYRPEQAPVDLAAVGAQIKAVYEATIVAAGLSPIRLAMECGRMVTGPYGYLVSRVIHKKKTYKNYIGLDACMANLMRPGVYGAYHHISVLGREPGTTPSLVCDVTGSLCENNDKFAVDREIPDPELGDLVVIHDTGAHGHSMGFNYNGKLRSAELLWQGAADASSAPQWRLIRRAETLADHFATLDYPGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJZ9</accession>
    <name>A0A139SJZ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureA</name>
        <name evidence="6" type="ORF">AXK12_06495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712559.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06495"/>
    <dbReference type="EnsemblBacteria" id="KXU34881">
        <property type="protein sequence ID" value="KXU34881"/>
        <property type="gene ID" value="AXK12_06495"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="100" mass="11077" checksum="6C9FFDE37D20F5F4" modified="2016-05-11" version="1">MELTPREKDKLLIFTAGLVAERRRARGLKLNYPEAVALITCALLEGARDGRTVAELMHEGTKILTRDEVMEGVPELIPEIQVEATFPDGTKLVTVHNPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK04</accession>
    <name>A0A139SK04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LPS export ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_06655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712607.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06655"/>
    <dbReference type="EnsemblBacteria" id="KXU34908">
        <property type="protein sequence ID" value="KXU34908"/>
        <property type="gene ID" value="AXK12_06655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="28608" checksum="15CE09CE4D2AB3E2" modified="2016-05-11" version="1">MSESLVDTSPHAAGSVSTDEKDALSAHGLVKTYGPRNVVDGIDLSFRPGEIVGLLGPNGAGKTTTFYMIVGLVPATRGLVSLGNTDLTRLRMHERARLGIGYLPQEPSVFRKLTVEENLLAIAEATQVPRAERRTRVAQHLEELSLTHVAKQKAFTLSGGERRRLEIARSLVTRPKFLLMDEPFAAIDPISVAEVQRIILQLKARGIGIVITDHNVRETLRIVDRAYLIHQGRVLTHGSAQFLIGDAQAREFYLGEDFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK29</accession>
    <name>A0A139SK29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HlyD_D23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712592.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06620"/>
    <dbReference type="EnsemblBacteria" id="KXU34901">
        <property type="protein sequence ID" value="KXU34901"/>
        <property type="gene ID" value="AXK12_06620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="58"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="392" mass="41876" checksum="7BE7D52273E8BF2D" modified="2016-05-11" version="1">MKRFPCIPLFLATVIFIGLGTSGCARKKAGEGSGGASAASPAQRAQVVEVAPVIRSDLREAMSVVGSLEANESAQIRPEISGLVQGIYFEEGQAVTRGQLLMKIDDAELRAQYAQVEARFDLAARNVERSESLSESRTIPQSEYDRARSEFAVARAELEVLKLRIEKTAVKAPFDGVTGARLISPGDYVTSGSVLTTLNDLSRLKMNFQVPERYLSKVRPGTEFRINARSLAQVDAQSGVVAADAGLSGEVYFVNPIIDRGTRSSEIKGYLHAPPPALKPGMFANVDLTLEVRRGVLTVPEGAILTVTSGTQVIAVVENERGEPVAEFIPVRIGLRAQGLAEIEPLGGATLREGQSVVAAGVGALVLYPRIRLDPRPLRAEFAPASAQIAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK37</accession>
    <name>A0A139SK37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712617.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06680"/>
    <dbReference type="EnsemblBacteria" id="KXU34913">
        <property type="protein sequence ID" value="KXU34913"/>
        <property type="gene ID" value="AXK12_06680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="147" mass="16055" checksum="A3321385D49110F8" modified="2016-05-11" version="1">MKFSIAIGSDHAGFRYKEAIKAMLLEEGHTVRDYGTDSGETSCDYPDYCFPVARAVAAGEVQRGIVLGGSGNGEAMSANRVKGVRCGLCWNEQVAIWNRAHNDANCLSLGERTISLEDALRIVRVWLATPFEGGRHLPRIEKLDSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK39</accession>
    <name>A0A139SK39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712570.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06530"/>
    <dbReference type="EnsemblBacteria" id="KXU34886">
        <property type="protein sequence ID" value="KXU34886"/>
        <property type="gene ID" value="AXK12_06530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="133" mass="14374" checksum="406878B06B628A58" modified="2016-05-11" version="1">MSSPASSAATAEHKPFSLVEILIVLIIIALMAAMSLPIFAWLRNSAREKAVLENLRKLDVAAQQYYLEQGSNTAPYEALVGPEKYIDRLKSVAGEDYSTLVFDSAAPELSISAPKIKGGKVITLRRASAPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK49</accession>
    <name>A0A139SK49_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712660.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06580"/>
    <dbReference type="EnsemblBacteria" id="KXU34931">
        <property type="protein sequence ID" value="KXU34931"/>
        <property type="gene ID" value="AXK12_06580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129684" checksum="D090A27B9B17F647" modified="2016-05-11" version="1">MGLRSSASTESPTPEDEALLPLYINLRLRYLGLPPFPLQEGAAALDTLTSGLIALSREKDRLLSRFLCPADRRIQNYLDRLLGEGAPQLPHTTFVLDRHGLARTLSLPPDRDHFESAIVSSYRVRQGVLHNPRSDRRTTQGLFHIAEGGLPIPDDKKAVPLDVFGRLLDHALRPTAELMELPFLSTTPKPAHAAHAQPTGCFLSLLLRPVICPAVPGVSPEKSMEIRFFAPGNLVCNLDFVESIFGNAGDPRLPENDAALDPEHWSGHTGCVILAPHLTRLTKRELGLPHWDQASPRQQRDGMCWREPSELYNDGQAFKITARDASGVIITLLSDNYFGYCKKEVKTQISYATNLYGLAEEEHAGGALIFTRYDLSEDFKANRILKKYPHRLDEALALLGDRALPQPDGSALDRDHPDIVYVPAESRFTLTGGAAVTWQHAGRTVTQLLRPGHVYILPSGYKVHLEKPRDSRTWRLVGTNAECMLAHKPCTVSGGGKSEISKSLSDAILAGPVFVMDFESDFTQVAELLARDYSTRFRDTTRHGSDQRPILSNERSLGSVIKLLTPSRAEFSADYNDWLQTIPQHIKELVFTVKRFYRPEWGDDWRTHFGVDIVNGTPANELRFEGHRIDANFLRVGFLPDGGWRTFGLRMDFQPALKIQVEDDITSSVVVPRKQLASGLGRLDGLSSTTAEPSLKFVHNCEYRLFQRPDEAIRRGYDHQTESDFAQEDNFFSNYEALTPADARALVEDALRLDQFTAPMQALIRRACSGKPDYFVSSAHPRIVDGQPSKNPRYLQVRSNLRNPRETYIAKIGLHLARRVPLDQPVHTPINAVLAGRRNNPAAPKSGIRSLAVYGPLHYMELPELFMEFICSLTGKSPSTTGAGSEGALTKGPFNALPPIYDLNATLVSYAVTGYPGFLSSAGCVGPKARVDHDISLLIPEVWCRIGPQERVPASLIAEGHLERCEDFEHAGRRVLASRLGYRITRRFVSHFCGRVFNHPHVIFTDDMLRPEQQSLDEFADGIDNIVSTQRAVAEHYFADGSIALACPPLRALLHLMRDGHYEGETLAAPAFRARFDAAAILDSDWYHDRLTAKQRIDSAQWSTHCSYLEAFLARDSYAAEAQRLGIATRLHAARKRLAHVQSPAYLDELRGTIGAEPALAPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK50</accession>
    <name>A0A139SK50_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712529.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06405"/>
    <dbReference type="EnsemblBacteria" id="KXU34867">
        <property type="protein sequence ID" value="KXU34867"/>
        <property type="gene ID" value="AXK12_06405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="32762" checksum="F927CF1CB4238F94" modified="2016-05-11" version="1">MAKKQTGIGRQIGGQSVREDFNDLRAVIHYTKAAHELGLWASERILIDRFFPNKRARLLEAGCGAGRVSVALAESGYTRLSAFDFSEELLAQAQGLVHERKLTRRVTLFFADATRLASSPALRDAISGLAGKSEPDSQTPTNAATTGAHFDGALFLFNGLMQIPLRRNRRRALRQLAAVCRPGAPLLFTTHDRDDSPEERALWRLEATRWARGQQDPILREFGDRYYEDVDIGRTFMHLPTRTEILADLKATGWAHEYDAMRRNISRESRQVREFSDECRFWVARVCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK95</accession>
    <name>A0A139SK95_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transporter SenC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_06150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712436.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06150"/>
    <dbReference type="EnsemblBacteria" id="KXU34946">
        <property type="protein sequence ID" value="KXU34946"/>
        <property type="gene ID" value="AXK12_06150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021647">
        <property type="entry name" value="CusF_Ec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042230">
        <property type="entry name" value="CusF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11604">
        <property type="entry name" value="CusF_Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="137"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="298" mass="32745" checksum="6A767F68893EC024" modified="2016-05-11" version="1">MQSITRATRVGLFGLLIFAASCDRNAPPAEAESAQETGYPLVGEVISVDAAARILVVHHEEIPDYMPEMVMEFSVSAGDVANAQVGQKIRAKMIPQDGGPYRLVEIWPLDPMSDSLVKAGADALRQDTMIRGRGVYREVGESLPGFTLYDQTGAVVQSTRFRGKQVMLNFIYTRCPVATMCPAATMKMMETQRLAAEAGVQNLELISITLDPEYDSPGVLRDYAAARGIDTVNFSFLTGPERAIRDLLAQFGVLAKFEGPLINHTLATLLIDTDGRIIHRADGTQWEPRDFVAKMHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKE4</accession>
    <name>A0A139SKE4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bac_transf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_00340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712412.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00340"/>
    <dbReference type="EnsemblBacteria" id="KXU35049">
        <property type="protein sequence ID" value="KXU35049"/>
        <property type="gene ID" value="AXK12_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="4">
        <location>
            <begin position="298"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="486" mass="54839" checksum="1A8F68C632546E51" modified="2016-05-11" version="1">MTPLRKTTLALLALDILAVFLCFNAALVFRGLDAPLVTSLIWPALFSIAALYLIDGYTTRTDMLSVDYTSQHLIALLAALLGTLLTLYVFQPVAYGLTSSRGVIFFAFAALAPLSLSYRRIGYARARAFRQSHPIIFIGTHASTHAFQAECDQAGVSQPLLFARSDDNSEVTSPQPTGTTPPPKETSKDARPTPLAQNSQGEDFASPPTEPLEALLRKIETGQLTAHAIVLCDDTQHRLPDALSQRLAQAYFDGTPITTRERFHQAYWRKVGLYRLDHHWPFQDGFAIARVPVFEHIKRLSDILLASLGLLLSLPLMALCALGIWLDDRGPILFTQTRIGENRRPFKLYKLRTMRCRPAEQSGDKYTQASDPRITRIGRFLRTSRLDELPQLLNVLLGDMSMIGPRAEWDELVRHYETAIPCYHFRHLLKPGITGWAQVNYPYGANLQDTLRKLEYDLYYIRHFSFRLDAAIILKTIHIMLFGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKG4</accession>
    <name>A0A139SKG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712367.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35026">
        <property type="protein sequence ID" value="KXU35026"/>
        <property type="gene ID" value="AXK12_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="213" mass="24477" checksum="9AB8E9880F58F862" modified="2016-05-11" version="1">MFSLKKLFGKDDKFYDLLEAGADEAKASVSLLEGYLEQLYKTGKPPENLDEFMHSRRAEKRIRNLVLEELSRTFVTPLEREDIEALSVALYRVPKSIEKMVERLSIYPGRVPHTAFQRQAELLKLAAEAVVEMVRQLRSGTNLEKIRTATDRLHYAEGEADRVMFDLLKELYQGPYEAKELVILQEIYELAEQSVDCCRNAGNIVVQIVLKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX2</accession>
    <name>A0A139SKX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712179.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05790"/>
    <dbReference type="EnsemblBacteria" id="KXU35213">
        <property type="protein sequence ID" value="KXU35213"/>
        <property type="gene ID" value="AXK12_05790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02827">
        <property type="entry name" value="RNR_anaer_Bdell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="684" mass="78841" checksum="956DC27E0A0CE793" modified="2016-05-11" version="1">MPPQAQPSHSLPRHNATHESYLSHKVKFIGDYLSAINAASGSKYDANANVTEKNLATLSGELFKGEIIKLNRYRLSQKIKALYGESLAKEYLRQLETHELYKHDESSIYPYCVTISMYPYLNNGLKEIGGLSAKPKNLDSFCGTFINLVFAVSAQFAGAVATGEYLLYFDYFARKDLGPDYHKSHDNFLIVGSELRKLITRSGKWFKNISELQNHDFAEKELNTLKERLLYEAQIHPGTLSDGTRTIDSHLTQKFQQVVYSLNQPAAARNYQSTFWNISYFDKNYFRGMFESFVFPDGSTPQWESVSWLQKRHMEWLNEERRKNVLTFPVETMAMLTDGQDIIDTEYADFSAQMYAKGHSFFTYLSDNPDSLASCCRLRNEIQDNTFSYTLGAGGIATGSKSVMTLNINRLVQNATRQNLNHVDYLRAQVLKIHKYQSAFNEILKEYYEDDALPIYKAGLISMEKQYLTIGINGMVEAAEFLGIPIKPCEEYRQFADSILKVFYEENRKARTKELMFNTEFVPAENLGVKHYKWDKEAGYVVPPTRNCYNSYYYASEDESLTLLDKFRLHGRDFTKYLDGGSALHMNLDHHLSKEQYRQILRIATVYGTNYFTFNIPNTLCNNCNHIDKRYLDTCPKCASHDVDYLTRVIGYLKRVSNFSVGRQTEARRRYYLGEGRVSLGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY7</accession>
    <name>A0A139SKY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712122.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35187">
        <property type="protein sequence ID" value="KXU35187"/>
        <property type="gene ID" value="AXK12_05640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="82" mass="9495" checksum="D1FCB94B91EF105C" modified="2016-05-11" version="1">MMRPTKHSHPDRTIINVSLLLLSRLKDRRIDEYDVLRKFAKKHVVGGDVLFLPALNFLYLMGLVEYRPKTDAVEYVGPNEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL48</accession>
    <name>A0A139SL48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712202.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35220">
        <property type="protein sequence ID" value="KXU35220"/>
        <property type="gene ID" value="AXK12_05825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="64"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="279" mass="30990" checksum="63FDF8E0B12DE3BF" modified="2016-05-11" version="1">MSMLGQNTVNLSPEEAVQGDLFELWRQGDAEVKAVVAPDGRAASGGQIKGAAGAIRFERSVRARHYRLTLRRDGTALVTIPAHGSQRAAEKFAAQHAEWLARARERQAQRPQVPTVWALGTAVLWRGKPCEIRVASAAELGSSKWRVQLSLGGELFRVATLAGDLRPTLEAHFARIARAELPLRTAELAASVGLAVRRVTVRDQRSRWGSCSSRGTISLNWRLVQTPAFVRDYIIYHELMHLKEMNHSARFWARVEEVCSVWREAEAWLKQNASLLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL64</accession>
    <name>A0A139SL64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ORF">AXK12_05440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712046.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05440"/>
    <dbReference type="EnsemblBacteria" id="KXU35293">
        <property type="protein sequence ID" value="KXU35293"/>
        <property type="gene ID" value="AXK12_05440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="148"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="45691" checksum="069BE2F36452770B" modified="2016-05-11" version="1">MPTTVSSITAREIIDSRGNPTVEVDVTLADGSLGRAAVPSGASTGEHEALELRDGSVKGAKPAAKARYLGKGVQTAVANIKNTIAPELIGYDATDQVGIDRAMLALDGTATKSKLGANAILGVSLATAHAAAAALGQPLYKYLGGPNAKVLPVPMMNIMNGGAHSDAPIDFQEFMIRPVNFDTFADALRAGAEVFHHLKKVLHDKGLSTAVGDEGGFAPKLASATAALDAIAAAVKAAGYKLGKDIMLALDVASSEFYDAKTKRYIFKKSDGRILTGEELVAYYQELVAKYPIDSIEDGCAENDWPTWKKLTDAIGDKVQLVGDDLFVTNVEFLRKGIETGTANSILVKVNQIGSLTETLDAVELAHKNRYTAVISHRSGETEDTTIADIAVATNAGQIKTGSASRSDRVAKYNQLLRIEEELGSTAIYAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLE5</accession>
    <name>A0A139SLE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_05175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711945.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05175"/>
    <dbReference type="EnsemblBacteria" id="KXU35367">
        <property type="protein sequence ID" value="KXU35367"/>
        <property type="gene ID" value="AXK12_05175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299335" evidence="7">
        <location>
            <begin position="24"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="9">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="8">
        <location>
            <begin position="383"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="754" mass="84171" checksum="F9388FC7383D0F58" modified="2016-05-11" version="1">MKPPKLLPLALSLFTFLLGSLHAQQSPDQSDDDIVRLSPFAIQESADMGRYQAIESTSGSRVRMDLMDSTQSISVLTNEFLSDIGTAQLLDAVKYVAGIGNASSTDTMDIMNIRGFLNWEMVTVDGFGQTSYINLDPIIIERIEIVKGPNAIIAPQGLPGGLVNNVTKRPLFKNSGSVSYQVGRYDSNRAEIDANYVVKDDKLALRVVGAFTDADKYLKEKYSQNLTVMPMLTYRISPTTELTAQVIVYNGTATLTNIPLSIYAVGRRNVHILEGLPRDFALSNRDDNRHESGQRAQFLLTSQITDKLSMRLAGKWAQQSSRASEIHPSSPRDVNGDLLDPQPVQVNPITGAWEWDGIIRSDEVRFTLAGVKDMTDLDHANLQSDFVFEHLGQGWKSQTVAGFAINYRSTGGGYKIAFATPVNGSNLFDLTDSSYTPVSFIVEPDWAFHSSLRNRSNQVYLYQVFNLFDDRLVLSGSLSQNRYFSGGTDNLSGTSTDDRAEATLPSGGFVYKLTPEVSLYYGYSKQEILGIAHPKDLIPTHTSPSRQHEGGLRLRLFDGRLYTTFAYFDIQQDGLWEGSLANWIDPTAPKEPAITSNRTSKGFEFEFAWSPTKNFSLIGSFTDFKSRDQGNRRYSHIAERMAGIWGSYSFSETGSLRGLSFGLGANYVGDRPSDTLGQYTTPPQGFQPARYQPLFWIPSYIEVEATATYRFNKHWKAQLVIKNLLDKDYIKVATNRTIYPSTPFNPKLTLRYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLF3</accession>
    <name>A0A139SLF3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">AXK12_05300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711985.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05300"/>
    <dbReference type="EnsemblBacteria" id="KXU35388">
        <property type="protein sequence ID" value="KXU35388"/>
        <property type="gene ID" value="AXK12_05300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="237" mass="25970" checksum="D3FE364F7D5EEC7F" modified="2016-05-11" version="1">MNPAAAAPIPFPVDLPLVREYFPELGEGVVGQLVELARCILDWNTRINLISRKDAAHIEEHHILHALTLTKVLRPPPAVASEGGSAPSASFADLGTGGGFPGLVLAICYPQCRFTLVDSVGKKIAAVGEIARELGLKNVDARVQRAETISQKFDYVTGRAVTALPTFLGWARPLLKKDSRARTEAEPSANGGVYYFKGTLWREELAGGTWQPSSLWPLDKWIPRPFFAEKFLLHFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLK2</accession>
    <name>A0A139SLK2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711952.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35370">
        <property type="protein sequence ID" value="KXU35370"/>
        <property type="gene ID" value="AXK12_05200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299340" evidence="2">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="326" mass="35326" checksum="C59107DED28D21A3" modified="2016-05-11" version="1">MNTPKRLSLLLLLALLAFGLTTQADAQSANPAQNKKGEELVRANRSEASENATQPDSEPQSDHAPKRAPRRERRGQAGSSSYGAEGSPSLWRRSSDLRGGVLHSEPTGSAQNNGALDSFDAFPAAAAKRPIPPRAVSENVAAQLAARMPQYTPPPEPKPKPDDQDAPDGELADMRDTDRPKNQILRLPDYVVREKKSPILRERDIHSPSGLAALAANRYLSETGQALNRFRLPLIGSAAQAYALARYEEDERLRNIRDLNDTARDLGQLQNAQASSSGDAVPTWGTLPASHGASARRATDAEASLRRLIRDTTSRRATEPPSKLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLS9</accession>
    <name>A0A139SLS9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05125"/>
    <dbReference type="EnsemblBacteria" id="KXU35505">
        <property type="protein sequence ID" value="KXU35505"/>
        <property type="gene ID" value="AXK12_05125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="385" mass="41561" checksum="2F5B0FA089E7E857" modified="2016-05-11" version="1">MISGFLGAGKTTLLQNLLANANAGDGARWAAIVNDLAALNIDGRLIEQAGASRVVELANGCVCCTVRDALAETVAELAASGRYAHLFVETSGVAEPRAIVSLFTRPNAFGRSLSDFARLHALVTVVDAAQWRDVWRRLARGSPLTCAAHARRSGEPKAPSELMLEQIECADLLLLNKADLVSLDALGELAAALRGLNTRAEILTTREARVPTGFLPGAARFDLQATLSAARWLKVLDASAGGSAASVFRPDEATPSARQEKGTSPGWQTFVFRERVPFCEARLRAFFAEKRPPGLIRAKGFFWVKERAADMGYLSLAGEILRSDFVGNWASALLERGLITESEISEHARAVWAEPYGDRRQELVFIGQGVDTAALERALRECLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM13</accession>
    <name>A0A139SM13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711851.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35598">
        <property type="protein sequence ID" value="KXU35598"/>
        <property type="gene ID" value="AXK12_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="144" mass="16043" checksum="FB11DBDC7D82ECF6" modified="2016-05-11" version="1">MKSELNFLVIKNETLFIDGIDFCDTLFIRPKINGMDIIADFYNNDCLAVADEWINASVRSMAALTECHYAWGGSVSLHPFNLGIGPVAKRRSQSPDLKSLLLVALRQGRGKEMGSAAGFPRREESRKAHVPKFGFLFTEPSFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM93</accession>
    <name>A0A139SM93_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711826.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04880"/>
    <dbReference type="EnsemblBacteria" id="KXU35652">
        <property type="protein sequence ID" value="KXU35652"/>
        <property type="gene ID" value="AXK12_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="162" mass="17245" checksum="36B03EFC6858A6B6" modified="2016-05-11" version="1">MSSSTPGPIVVVCTANICRSPMGEGLLRHALAAETEPLCSIPIISSGVSARSGDVVSENSVFALRKVGIDIAAHKSQPLTQAMLDSALLILCMTEAHRAMIRLQASPVPRELRLFREFMPVGNRREIADPYGGPSALYEACRDELVEAIPSVIAHIKGLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMG2</accession>
    <name>A0A139SMG2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ORF">AXK12_04870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04870"/>
    <dbReference type="EnsemblBacteria" id="KXU35650">
        <property type="protein sequence ID" value="KXU35650"/>
        <property type="gene ID" value="AXK12_04870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="116"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="439" mass="45517" checksum="7DD249C49B3E45FE" modified="2016-05-11" version="1">MTTFPSLPSSVLVVGSGGREHALVRGLRASASAPRVICAPGNAGIAADGVECFPVAADDVAGLVALAQRERAEFVVVGPEVPLALGLADELRACGIPTYGPGKSGARLEASKIFTKELLFKYKIPTAAAGIFDEEAAALEYLESHAAPIVIKADGLAAGKGVTVAQTDAEAATAVSEMFAGKFGASSSKILIEDCLEGEETSILVVVSGRDYVILPTSQDHKRIGEGDTGPNTGGMGTYSPAEVVTPEVFARIEREIVRPSVDAIADEGIEFRGTLFIGLMLTVDGPSVIEYNARFGDPETQVVLPRIESDLCELLWRAACGEGALAGYALRVKPDYAICVVMAAAGYPDTPRKGDAISFPAAAALAESVSIFHAGTAHDAAGRVVTAGGRVLGVTATAATLADAARAAYGACEQIDFSGKYYRRDIGARQLARENAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMN4</accession>
    <name>A0A139SMN4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35847">
        <property type="protein sequence ID" value="KXU35847"/>
        <property type="gene ID" value="AXK12_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="26870" checksum="D9364EE91B8564DE" modified="2016-05-11" version="1">MDLLVIFPTPPKRVITLLSLLLLALSQRDRGNAFKFGISLSRDSAMTKSQIKWKRSLTAAPRVVRKRVLASSSSARGGAVSGKEFAWALLFPTLLGVMPKTATAVGPQILAQAARKAREQGRGVRSHRSTRDAPVEERVAVLEARWEETVPTLATSRDISDLRGEMGELRGELRGEMRSLENRLLKWGVGAVLALLAVLAATFSATNARIDSLAARQDARMDALDAKLDARFDALMTELRAIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN80</accession>
    <name>A0A139SN80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711544.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04220"/>
    <dbReference type="EnsemblBacteria" id="KXU36036">
        <property type="protein sequence ID" value="KXU36036"/>
        <property type="gene ID" value="AXK12_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="479" mass="52486" checksum="B581E7CF05565BFD" modified="2016-05-11" version="1">MLPFAKATRALVRRLGPALVDTSEEGRWAASFDSSKLSFLPEAVIMPRRHEDIGPVLELANAQGVPVTVRGRGTTLMGSAAPIAGGWVIDMLRLNKVRIDAEAGMAHVQAGAVNAQVQRAAAAAGWFYPPDPASKAYCTIGGNIACNAGGMHGGKYGVTRDFVIALSGYLPTGEWVQWGVATRKFSAGFNLRDLWIGSEGMLGVVTDAVLRLVPAPAARWTLLTAFASEVEAVEAVRALFREVRVQPAICEFLDRDSVHCAERATGRPVFVGQRDRAVVLFELAGSASEVREESKKLLAWAKTHAVAQRVAKNREEAEQLWEVRRKCSGAMFELGDSKLNEDIVVPMRAYSRFMRFLAQLKKSSRLHIPTFGHLADGNLHVNIMFNREDADQARRAEAAVERLMRKVVELGGAISGEHGIGLAKTPFLRIQHSPAQVRAMQAVKAALDPRGILNPGKMFDVFEVWKQEKLNLKLPWDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN86</accession>
    <name>A0A139SN86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36083">
        <property type="protein sequence ID" value="KXU36083"/>
        <property type="gene ID" value="AXK12_04495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="142" mass="15412" checksum="0A561C303E27394D" modified="2016-05-11" version="1">MEARRARLRAWIDAHHAGSQAAFVKATGINQGGLSSLLRSKAFGENRAAAIERLADMPEGYLVFPLDEAEKTPVAVQLVTRRFEDFGPKLKTLLCELGEAAQASPEIAAHLETLKPLARKHLQACAASAELKKLKRRGAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNA8</accession>
    <name>A0A139SNA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">AXK12_04680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711720.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04680"/>
    <dbReference type="EnsemblBacteria" id="KXU35980">
        <property type="protein sequence ID" value="KXU35980"/>
        <property type="gene ID" value="AXK12_04680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="38801" checksum="6F4CC1832943AD04" modified="2016-05-11" version="1">MSETLELSFEDAARNYPIFFAEDLSTQIRQAVAALCAEGRRAVVFTDENFLNAQGAFLDASFGPKGESGGVSRLVFAAGEGTKSVAELARAWDFLGAQRVDRGGVIFAVGGGVVGDLAGFAAASWQRGIAFYQVPTTLLAMVDSSVGGKTGINIAAGKNLVGAFHQPRAVFVSTGLLQTLPPREFAAGMAEVIKYGLLGDLGLFEQLEAEALRVGSAGLGPVIRRCCEIKAGIVRADERETAKEGGRALLNLGHTFGHAVEQVAGYGAYLHGEAVAIGLVAAGDLSRRLGFIDAQACERISAVLAAHDLPLRLREPLSAEALIDAMRRDKKVRAGLPRFVVLRALGEAITKDGISEELARACFAGIGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNG5</accession>
    <name>A0A139SNG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">AXK12_04570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711666.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04570"/>
    <dbReference type="EnsemblBacteria" id="KXU36096">
        <property type="protein sequence ID" value="KXU36096"/>
        <property type="gene ID" value="AXK12_04570"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="377" mass="41711" checksum="5AFEEF71FD8A97A2" modified="2016-05-11" version="1">MTDDCPHFHVLKTDSDTGARRARLHTRHGAIETPIFMPVGTQGTVKAMTPVQLREIGAQVILGNTYHLNLRPTSELIAELGGLHRFMGWDGPILTDSGGFQVFSLAKLRKLRDDGVAFQSHLDGKKLFLGPREVVDIQSRLGSDIAMVLDECPPWPCERGPCAEAVARSARWAEQCLAHARDTGFFERGQLLFGIAQGSTYDDLRREAAESLAALPFSGYAVGGVSVGEPEDEMLKQVAATIPHLPAHKPRYTMGLGTPPQMLKMIALGVDMFDCVLPSRVARHGLVFTPDGPLNLRNAVHTRDPRPISEEVVNYTTQFSRSYLRHLIQAGEILGCTLLTLHNLHFYLDLMAQARAHIEAGDYASWHRAWCARYEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH2</accession>
    <name>A0A139SNH2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36040">
        <property type="protein sequence ID" value="KXU36040"/>
        <property type="gene ID" value="AXK12_04245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="272" mass="31004" checksum="26567CA43052146C" modified="2016-05-11" version="1">MMSMIMTVLVLFCALLLLMLVLMFPEVIPVRYQLIARLDCPDGEFVIDVRPYNPSLAGTAFLDIRYRYRGVVLTGISYNGYDKYLLKYLHQVDPELREQITRSGFTLYFPPEQFGADEVARVAACINANQWELEKASYKNIFGKFSFGLVSTRTELSHYKPHEIDLIICANSPIADLYSDDYLTIIIEREGAVILLIEPAGTKVPAEAFSWGKVLPPRFGFGRPRLELNPVIFNGETYDSQFAKLLGRHTYGLNRRTINQNYKVVPPVSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNH4</accession>
    <name>A0A139SNH4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_04425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711682.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04425"/>
    <dbReference type="EnsemblBacteria" id="KXU36106">
        <property type="protein sequence ID" value="KXU36106"/>
        <property type="gene ID" value="AXK12_04425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="321" mass="35703" checksum="7AD6606043767AF0" modified="2016-05-11" version="1">MRTLTGIQPSGSLHIGNYFGAIKPALAAQSEGDCFFVIVDYHSMTSLTDGPRRRANTREAALDWLACGIDLERSVFWKQSAVPEVCELTWILGTLAPMGLLERAHSYKDKVARGISPHFGLFAYPVLMAADILAFDAERVPVGKDQKQHVEMTRDLAAKFNQTYGQTFVIPEYESRYGVATVPGLDGQKMSKSYGNTLEIFGEEKLMRQKIMSIVMDSRTREEPKPDADQNTAIQLFRLVAPEAVAADYEARLRAGGLGYGDLKKALFEHYWEFFAPFRKKRAELAADPAYVDHVLAEGAARAREVASSVMKRVRNATGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNJ8</accession>
    <name>A0A139SNJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711416.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03890"/>
    <dbReference type="EnsemblBacteria" id="KXU36203">
        <property type="protein sequence ID" value="KXU36203"/>
        <property type="gene ID" value="AXK12_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="236" mass="26737" checksum="FC6DDA3B5DDD7CBF" modified="2016-05-11" version="1">MKLSIVIPCYNESRTLLHLVERVRAACENPTTGAAIEREIIIVDDCSQDGTRELLRDTIAPLVEQVLYHEKNQGKGAALRTGFAAATGDLVIIQDADLEYDPGEYPKLIAPILAGKADVVFGSRFSGGDAHRVVYFWHMLGNKFLTLCSNMFTNINLTDMETCYKVFRRSVLDKIQIEEARFGFEPEITAKVAKLRVPIYEVGISYYGRTYEEGKKIGWRDGFRALWAILKYNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN9</accession>
    <name>A0A139SNN9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinol-cytochrome C reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711678.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04400"/>
    <dbReference type="EnsemblBacteria" id="KXU36104">
        <property type="protein sequence ID" value="KXU36104"/>
        <property type="gene ID" value="AXK12_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="147" mass="15957" checksum="EDFA2BDE4A350EDB" modified="2016-05-11" version="1">MKKQHWLVKSEPSAYAWADLLRDGETDWTGVRNYQARAHLAAMRVGDLVFFYESVSTKAVLGIAEVTQAAFPDATATGADAAKGWIAVKLRAVRALPRPVTLAQIKAQPEASGLADIPLIRQSRLSVMPLSAAVFEKIEQLGRASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNX2</accession>
    <name>A0A139SNX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711364.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03745"/>
    <dbReference type="EnsemblBacteria" id="KXU36257">
        <property type="protein sequence ID" value="KXU36257"/>
        <property type="gene ID" value="AXK12_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="339" mass="36807" checksum="01632A7F4B48E49B" modified="2016-05-11" version="1">MNNAPSAAIPEQPALPADADNFYQSDALSVEKVRFRNQYGMKVAGNLFVPKARAAAVADVARLPAIIVGHPMGAVKEQSSNLYAQKLAEQGFVTLAIDLSFWGESEGVRNVVAPDIYSEDFSAAADFLGLDARVDRERIGVLGICGSGSFAISAAKIDPRLKAVATVSMYDMGAANRDALGKSQTLAQRAAIIEAAARQRWVEAEGGAVRYTSGSVHELRADSHPIEREFYAFYRTPRGEFTPALSSPETTTHPTLSSNTKFMNFYPFSDIETISPRPLFFVTGEEAHSREFSERAYELAAEPKQILRVPGAGHVDLYDRVGLIPFAELGAFFGKHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP39</accession>
    <name>A0A139SP39_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoD</name>
        <name evidence="5" type="ORF">AXK12_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711354.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03695"/>
    <dbReference type="EnsemblBacteria" id="KXU36250">
        <property type="protein sequence ID" value="KXU36250"/>
        <property type="gene ID" value="AXK12_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="4">
        <location>
            <begin position="154"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="425" mass="47166" checksum="7743BA139C7F7858" modified="2016-05-11" version="1">MPTEFNFPDTAAKNASAAPRVAVARGDSAQLPPQEFEPERMSLSMGPSHPSTHGVLRIQMELDGEVVTEARPVIGYLHRGDEKIAENMTYNQFVPYTDRLDYLAPLANNMAYAIAVERLAGLEVPERCQAIRVITAELARISAHLIGLGAFGIDTGAWTIFLYTFTEREKLYRLFEELTGARFTTSYTRIGGVARDLPEGWTGRVLEFCDQFLPILEEILSLLTRNKIFMDRTVGVGVISKEDALSYGLTGPNLRGSGVAADLRKDRPYSGYERYEFDVPVGSTGDSYDRYLVRGEEMRQSVRIIRQAIEQLPGGDWYARDARRIFAPPKDKILSSMEELIQNFMIVTEGPQMPAGEVYFEAENPKGALGFFIVSKGGGVPYRLKIRAPSFCNLSILPKVCAGAMISDVVSILGSLDFVMGECDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD2</accession>
    <name>A0A139SPD2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711249.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36340">
        <property type="protein sequence ID" value="KXU36340"/>
        <property type="gene ID" value="AXK12_03375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299367" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="89"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="316" mass="34155" checksum="997FB7ABDFDC76B4" modified="2016-05-11" version="1">MKFSHFIALFCAVLMSVLSAAAMERVETRRVPLPDGGRVKISTGSGDIKVVPGDVERLELQLRCVSHEQKSQKARSVLNRVQLVMRRSDDTVSIDVLDRASGGTRLMSAKRLKMQFEVVVPQNCSLDVYTQEGSVQVGNLTGHMHVVTERGKIFLGQIDGHIYAATKRGDVSVSRSTGAAELKTDEGNVHIGTVSGHADLETKKGNIVVQAAYNTVSARTTQGDVIATLARVRGPNQLRSDMGNVRTTINPSENCFIAAKGRKVTSEIRLVLAQGGRDSGKHIGDYLGGGPRVEISAGGGKVQIVKGEPLFQERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPH6</accession>
    <name>A0A139SPH6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711239.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03320"/>
    <dbReference type="EnsemblBacteria" id="KXU36414">
        <property type="protein sequence ID" value="KXU36414"/>
        <property type="gene ID" value="AXK12_03320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="400" mass="42318" checksum="E7D4136E224C5768" modified="2016-05-11" version="1">MSDTEKSGAVLDEPTATTPAAQSGDTCASLGGDQPATTRLEESTTDQASQPDAQDQPQSDFAFGTSRGSGLARGKRKTITAPDAPAPQPNSNGYQPTAIEVITPKSEYSNPFTGETVVETPRQEELSQIETPKHEEPLIRTSPTSEESTAEPETSTTPNSSESSGETPTTQVQPKPELKILPPAQPNRSRQSWESPSEHPARRAAAAATDSEKTNNAATAEAPRSRSPRGSSEGRPTFQPERRSRSPRSDAGSEKPSREERPKREPRSEHGPRAAGSPTAKPTAKPQGFFGWLKSLFGGGNSKPSASGSKASGRSEQRHEGGPKRRSRGGRGRGTGNGPRSGSESFSGRRNGEKTAGEHASPSRGLDEQRDRPRNRSRGGRGGRGRSGPRSEGQQSGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPI6</accession>
    <name>A0A139SPI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03195"/>
    <dbReference type="EnsemblBacteria" id="KXU36466">
        <property type="protein sequence ID" value="KXU36466"/>
        <property type="gene ID" value="AXK12_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299352" evidence="2">
        <location>
            <begin position="27"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="377" mass="41132" checksum="C9483B39159954A3" modified="2016-05-11" version="1">MIRQLFSCFASILLLGGALGWTPAPSAPATGATLETWRGPETIGQITEAAINETSGLAASLHTEGLLWAHNDSGNEPVLYAIGPSGDCLGSVRIEGAVNRDWEDIASYEIDGRAYLIIGDIGDNNAVHPECVLYVIAEPSPDELSPTRQLTVTPERVIRYVYPGGPRDCESLAVDSCERSIYLISKRTQPPILYRLPLFPEDTSKHPLIAEDTSKRPLIAEELGPINGILQPSGLLSKMSVPWGKWRGQPCSLDISPDGKTAALLTYGEVYLYERQEGEDWASTFARGGHALAAHNLPQAEGLCFSRDGQSLYVTTEGSPAPLLRYTTRSTPDHAPKRKPRRSRRGQARQSFYGAEGSPSLWRRSSDRRVGVLHTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPJ3</accession>
    <name>A0A139SPJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000023">
        <property type="protein sequence ID" value="KXU36509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711213.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00035"/>
    <dbReference type="EnsemblBacteria" id="KXU36509">
        <property type="protein sequence ID" value="KXU36509"/>
        <property type="gene ID" value="AXK12_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299309" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="96"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="989" mass="108152" checksum="DD4EB5DE4069B3D8" modified="2016-05-11" version="1">MMFSPTVGRAAFLALSLGLSLAPSASVLLAQEPDAAADEFSRAPDQIAHAGSPLRSGVAAEDEAFVLSPFTVSTSADKGYRATNSISGTRLDTPIRELPMPIEVITESFLKDTGASDLRQSLRYSSGIILQSQNDQGANAFYGAGGVHNPEGATANKTQSTFKIRGYITDVVLRDGYRRQSATDSVNIGRIEVIRGPAALLYGIGNFGGIVNYLPKTPNLEAAESQVGVAYGSHELMRAWVDTTAPLGASGALGYRLTGAWQKTGNQTELYDEEHWFVSPSFEWKPFAKTDVLLDLEIGEQREEGLGFLSVRARSDVDGIGQADRLQSAGFVQFAGKDPRRFRWSGPDTYRESDQFNARVQVSQELAPGLNLLAGYNHSQVDFDVRDVNGSMRQNAGPVGLRDTITVLPIDVANGGGEFALGESPNTVFQYQWSDFEEESRRDQVRVELNYALSLFEGRSRWLANSHSFLFGRSTEKAQLKSALRRTANDTFNYKRPTDTSYIRYGRQGDGSADQPLVAINRTASTARNTGDYAVYQGKFLDNRLILVGGARSDKNENTVSASIYHPTASESAVRRPASRDTTDQFGAMVEITPQLSVYALRASGIQPNFDGLRDAAGDPLGPTVAKSKEIGLKIELANGRISGTISKFKIKRSGVPFGQWWMPTLKGNFDPTRPIIYNLSDFSPSTVSGGANGGNGAAEAAINQWNAAVASGAIYQRATGGVPTWYVNASTSEGAAYLDQVIANGQELGGWTGWLFTSDEHTNNGWEDRGDGGGVQSYVQQEDQSEGWDAQILITPSDNLQFIVTYAHTKRVITQPGKFIKYPYPENRWAPWFYPDGQWGLTGYPIEEVYPDPNDTSSWTGIGWGAGQSRDDTPKHSVSLWSHYKIDSWGGPLAGLEIGFGGQWESEREYFSGISVSGQKQADSKGKLITLKHKARLNLDLMLRYPFHLAQRPAYAQLNIYNLQDDRDLYGLIYAPGRSVRLEFGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPP0</accession>
    <name>A0A139SPP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_03245</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="LSZP01000024">
        <property type="protein sequence ID" value="KXU36474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711225.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03245"/>
    <dbReference type="EnsemblBacteria" id="KXU36474">
        <property type="protein sequence ID" value="KXU36474"/>
        <property type="gene ID" value="AXK12_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="346"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU36474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="49417" checksum="2787E50D7739F8A2" modified="2016-05-11" version="1">MAETTYDLVVIGGGPAGYAAAIRAGQLGKKVACIEAERAGGTCLNWGCIPTKALLKSAELYAKMQKSEVYGLRAEGLSFDFAKVVERSRGVSAQMAKGIEFLFKKNKVEYLVGRGQVSAPGMVSVVEGERKGEFLRTKNILLATGCQMRRIPGLDYDGERVMTSREALAATRLPKSVVIVGAGAIGVEFAYFYNAFGAQVTLVEMLPQVLPVEDEEIARQLHRSFEKLGIAVHTNTKCENFRVGKNSVTLDLVSGDKTSALEAEVLLSAIGVVPNLDGALAPSVKPELERGYLKVGDDYQTSVKGVYAAGDIIGPPWLAHVATFEAVSAVNGMFGHGTPHRVRNFPGCTYCQPQVASIGLTEKAAKEKGLSYKVGKFPFTASGKAVASAESEGFVKIITDTKTGEIYGAHIIGSEATELIAEYGLAIEMEATVEDVHRTIHAHPTLSEALMEAAAASLGEAIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPU6</accession>
    <name>A0A139SPU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000023">
        <property type="protein sequence ID" value="KXU36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711214.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00040"/>
    <dbReference type="EnsemblBacteria" id="KXU36510">
        <property type="protein sequence ID" value="KXU36510"/>
        <property type="gene ID" value="AXK12_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="302" mass="33504" checksum="32B496BF0FBA24AB" modified="2016-05-11" version="1">MTVLRMLFATESAAPTTSLEARTLLWQDEFAQPIGTGPDPSKWAHDLGEHGWGNAELQRYTDSRENSFVVADADATDGRALVIRALRDSEGRYTSARIKTQGKFAKKFGRIEARLKLPKGQGIWAAFWTLGETIERSGWPECGEIDIMESLGHEPDKVYGTIHGPGYSGGNNQTTAHYRIGQRDTDGDAGEDARRDALRGGVGAGTAPAVATAEAALDFSAGYHVFAVEWRPGQIEWFVDGERYHVLTAADFPEEARWVFDDTPQFILLNLAVGGHWPKYPDATTEFPQDYRIDYVRVWGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ29</accession>
    <name>A0A139SQ29_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711151.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02875"/>
    <dbReference type="EnsemblBacteria" id="KXU36715">
        <property type="protein sequence ID" value="KXU36715"/>
        <property type="gene ID" value="AXK12_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="246" mass="27411" checksum="D282A4EB2C6819CC" modified="2016-05-11" version="1">MLLSMQLFSAHKFKNYAEFIAVLAKMGYDAVEGYGANFEDVKSTRAALDKAGIRMPTLHMGLPLLEEDFDKGVGICRELGVETIYIPGIAETDKMTDVAAWTAFAQRLGEVGKRVQDAGLNYGWHNHWDEMKVLEDGRRIIEVLLDSAPNIEWQSDITWVAEGGADPLELTGRYSNRVTALHFRELAQSPTGPGALGRLLAWDAYFAPARNSKIKTIVVEHEAQPTVESLYAFSKEIADTYKTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA6</accession>
    <name>A0A139SQA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">AXK12_03055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711181.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03055"/>
    <dbReference type="EnsemblBacteria" id="KXU36746">
        <property type="protein sequence ID" value="KXU36746"/>
        <property type="gene ID" value="AXK12_03055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="402" mass="43609" checksum="BBFBC1CFCA3B7BB2" modified="2016-05-11" version="1">MARHAATPHDSAAPPHEKEKVLVALSGGVDSSVAALLLKRAGHDVVAAYMKNWVNEDGTIGHCPWEEDIRDARAVADHLGIEFRVVNLMHDYRRLVVDYLLESYQRGLTPNPDVMCNREIKFGAFLRYAEAEGFSAVATGHYARKLTTPALPQHAATRHAPASAQNRAAATACRLIEGADKNKDQSYFLALLTGAQLAKARFPIGHLTKPELRSLAAEAGLPTAQKKDSQGICFIGQIKMADFLRTYVPDAPGPIIRASDGLPLGQHRGLHYFTLGQRRGIGIPSNTDNKAYVVVGKRAADRALLVAFDDPSAPGLWTSEAHIHSLSFITTPITEATGLEARVRYRDPRIPIHFTPSKHSDGGAHIRFETPQRALAAGQIIALYRGEALLGGGVFGGTDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQC8</accession>
    <name>A0A139SQC8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711166.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36732">
        <property type="protein sequence ID" value="KXU36732"/>
        <property type="gene ID" value="AXK12_02965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="232" mass="26181" checksum="3331BDD477110053" modified="2016-05-11" version="1">MIINPRPANALRRASFILGTARNSRPSRHSPKAVALPLSLHWAHYGVRHRITAWPDVRLEKNYDGEWIPIRLDAALLESASLELSRPGHETHWACYLGFVPPPEREFIENFEFNRVSALFAAAHCPALLPELRRTPVLTVFLAEQFELRDTGSAAWAQLDAVYERAGIWGVLEWLGLPATTQPLHALGELDSPDLPRRFLERLRAQLWQAPQPQAQIARPALSTLFAERIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQD6</accession>
    <name>A0A139SQD6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">AXK12_02825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02825"/>
    <dbReference type="EnsemblBacteria" id="KXU36753">
        <property type="protein sequence ID" value="KXU36753"/>
        <property type="gene ID" value="AXK12_02825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="258" mass="28050" checksum="81A972B2E78EACF6" modified="2016-05-11" version="1">MLHTVAEWRASRAEFLAKTPNATLGVVPTMGALHAGHASLFAAARRDCDLVLATLFVNPTQFDDPSDLARYPRTLDADLALMAEQGVDAALIPPVEELYPPDTGTHYTVQEDHFSRTLCGTHRPGHFTGVLTVVMKLLQIAGATRAYFGEKDWQQLQLIKGMATAFFLETEIIGCPSVRGPDGLALSSRNRHLSPAERALAPQFYKTLCTAPDAASATAQLTALGFAVDYVEDLKAHQRRLSAIRLGNTRLIDNVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQE2</accession>
    <name>A0A139SQE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711146.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02845"/>
    <dbReference type="EnsemblBacteria" id="KXU36710">
        <property type="protein sequence ID" value="KXU36710"/>
        <property type="gene ID" value="AXK12_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="35"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="591" mass="63020" checksum="3D414D41AE72B266" modified="2016-05-11" version="1">MAAAQPERAALKIPRRRSAARSGPQGAAAREGRIDYLELSFRELEAEVDAWCAKLAAKSAGESWKGVRTLVMLRQGLPLIAAVFALFKLGAVPIVIDPGMGLKNFLRCVVRSRPKALVGIPLAQVVSRVFWQKFASVRWRVWASGALTGRVTPGPEREAVAVAETAADDLAAILFTSGSTGAPKGVCYTHGMFEAQLGLIRAQYAIAAGEVDLPMLPVFALFNPALGMTTIVPEIDPRRPAQVDPAKIVQAILQEGVTNSFGSPTLWLKIKRHCVAHGIQLPSLRRILCAGAPVPAELWEDTARWLPNGQLHSPYGATEALPICSVSSGEIAELKQSARPYRGACVGKPLPGITVKILEIVDGPIATLAEARELPRGQVGEIIVGGPNVTQDYDALPEATARAKVAVADRSTSRSVAGAASEPVGDAAVVDTPPTSGGQNRASPGLLHRMGDCGYLDEAGRLWFCGRVAERVQTARGDECGSLGAATLYTEPCEQVFRAHPQVARCALIGLGPAGSQTPALVVQPRAAKATKAEHAALTRELRGLALAHEHTAKIERFYFHPDFPVDVRHNAKIHRLTLARWAATAHAFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQG5</accession>
    <name>A0A139SQG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">AXK12_02830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711189.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02830"/>
    <dbReference type="EnsemblBacteria" id="KXU36754">
        <property type="protein sequence ID" value="KXU36754"/>
        <property type="gene ID" value="AXK12_02830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="27258" checksum="677DE23408829DBE" modified="2016-05-11" version="1">MEALRNFAAAKNSGHKISMVTAYDAPSARLISGTGIDALLVGDSVMMAVHGHSDTLAATPAIMALHTAAVARGGPGCLIVADMPFLSARKGTAYALDTAAELLRSGAHAVKIEGAGSTVAVIRELVEAGIPVMGHLGLQPQSVRATDGYHVQAKNPSEVLELLDDAQALEKAGAFALVLECIPSEAAKKITAKLTIPTIGIGAGPHCDGQILVWHDLHALNPSFKPRFVRHFGDASAESRRALSAYAEAVHSGQFPNAEESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQI5</accession>
    <name>A0A139SQI5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711175.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03020"/>
    <dbReference type="EnsemblBacteria" id="KXU36740">
        <property type="protein sequence ID" value="KXU36740"/>
        <property type="gene ID" value="AXK12_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="387" mass="42971" checksum="A6CB0ED632F34890" modified="2016-05-11" version="1">MKDATLKRLAYVFLFISAVLIAIALLAVRNIRLTAEASDWVNHTHSLIDRIDNTRSGLLRSEACLRAYAATGESGDLLTLNRALGAMRSELELALLMADEHSEPELHARLQEIDSLSESHTEVARKIVTARQAKTLPTLRHELDSFARSDTLGQIEQGLAYVKSELLTRLTERDTQLYLQVQSTRWSIWSGVVLDLLLLGAAGWLIRDDLANRRRAATALEEANAQLEVKVQERTAELQAANQQLSLDNLERQWANQALEHQLHYNHRIVECISDLVIVLTKAGHITRVNTAVLRFSGWDAAELVKEPFDKLVRLTGTGETPSAPSPDALNKRIADAMKDGRDLVDQAGLALGSEGREAHARVSLYPLRDQNKIIGGILTLRLTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQP9</accession>
    <name>A0A139SQP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_02655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36929">
        <property type="protein sequence ID" value="KXU36929"/>
        <property type="gene ID" value="AXK12_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="65" mass="7360" checksum="73DB5B614238559C" modified="2016-05-11" version="1">MICGMPEGTPFVRLRSKGRPVVYYAGSAAGFLHELARPIPYDKEEVRRKAGEVIGKRDDEIRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQV4</accession>
    <name>A0A139SQV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_02610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711101.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02610"/>
    <dbReference type="EnsemblBacteria" id="KXU36922">
        <property type="protein sequence ID" value="KXU36922"/>
        <property type="gene ID" value="AXK12_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="308"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="410" mass="42568" checksum="7975486E74465C67" modified="2016-05-11" version="1">MANSKKKAVTKPAAKKTSPAPKKTAPVKAPATPKATKPATPKKAAPTAKKTALKTPAKKPAVAPKPTPKSAKSATAPASTTKGSRLQLGKASATTAAKKPSLKPAAAIAEEKAAKKPESNKAASQTATARPSGGSSLATAAQARTAKTTALRASTGGGSPAKAALRTPPVRPVSFTLDEVRAIAKSNETKSEPAPKTSTAKASKKASTAATAPKAPKAVEIIPPAKPSHVKAASLADILGFNPNAKGSEAARPVPREVALVPEKFKRYYKLLVELREHLTGQIDQHSEDTLKRSSKDDAGDLSSYGQHMADAGTDTFDRDFALSLVSSEQEALSEIEAAIKRITDGSYGICEVSGQAISKARLLAVPFTRYSAEAQKEIERNHYRVRTQAGLFGELGGEDGGRIMDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR25</accession>
    <name>A0A139SR25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000018">
        <property type="protein sequence ID" value="KXU36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711109.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02660"/>
    <dbReference type="EnsemblBacteria" id="KXU36930">
        <property type="protein sequence ID" value="KXU36930"/>
        <property type="gene ID" value="AXK12_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="87" mass="9118" checksum="55B3A5EA1E63E533" modified="2016-05-11" version="1">MHTTNLRKVGGSVMLAVPPALLDALQLTAGAKVGLAVDNGRLVIEPAGRPRYTMAELLADAEAAGAYPLPAEEREWVDAPAVGRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR28</accession>
    <name>A0A139SR28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_02410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711083.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02410"/>
    <dbReference type="EnsemblBacteria" id="KXU37036">
        <property type="protein sequence ID" value="KXU37036"/>
        <property type="gene ID" value="AXK12_02410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="486" mass="51463" checksum="9F221F178E0FBD64" modified="2016-05-11" version="1">MPPVHADEAPSGLRIKKPSVAVIGGGITGLAAAHRLAARGVRVRLFEKSERAGGVIGTEQSEGAWLIERGPNSLLESGPAGATLRALVAELGLKSQTVPANPLAKKRYLVREGRPLAVPTSPIGLARSPLLSSSATWSILRELLRRRPTAPRPNDISLADFVRDHFCQEIVDYVLNPFVSGVYAGAPEKLSAQHAFPALWKAEQTHGSLLRAQIAAGRERRKRGEPRPQLFSFRRGLQTLTDALAHSLPPDTLQLGTTVRAIHQSADGGWEIETDAGQEAAAAVLCALPAHALAALRIGEETPLASLAEIEHPPVSTLFLGYRREQVAHPLDGFGMLVPKVEKLPLLGVIFSSTLFPERAPKGHVALQVMLGGAACDHRQLGARVGGPAPFGGDSGNPPSLGQVQLALAQLLGVRGDPVFLRSGHFAQAIPQYTLGHEKHLAAMTDCEARHPGLFIGGQCRDGISTPACIASGERLAAQALSQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR64</accession>
    <name>A0A139SR64_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ORF">AXK12_02275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711043.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02275"/>
    <dbReference type="EnsemblBacteria" id="KXU37089">
        <property type="protein sequence ID" value="KXU37089"/>
        <property type="gene ID" value="AXK12_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="540" mass="57257" checksum="9B2F6AABEF6D0B2F" modified="2016-05-11" version="1">MAKQLLFDESARQKVLHGVELLSKAVKVTLGPKGRNVVIDKKFGSPTVTKDGVTVAKEIELADAYENIGAQLVKEVASKTNDAAGDGTTTATVLAEAVYKEGLRHVTAGANPIYLKRGIDKGVEAAVAELAKISKKVNASEEIRQVATVSANWDAEIGNIIAEALEKVGKDGTVTVEEAKSIETTLDVVEGMQFDKGYLSPYFATNMETQEAVLEDAYILIHEKKISNLQEFLPLLQTAAKSGKPLLIIAEEVEGEALAALVVNKIRGTLNVVAVKAPGFGDRRKAILEDIAVLTGGRLLSEDLGIKLENVQLSDLGRAKRIVVDKENTTIVEGAGKSSDIQGRVKLIRRQIEETSSDYDREKLQERLAKLAGGVAVINVGAATESEMKEKKQRVEDALHATRAAVEEGIISGGGVALLRTGKAVDAVINSLEGDEKLGAQIVRRSVEAPLKQLCFNAGVEGAVVVQQVLASKGNNGYNVATGVFEDLVKAGVVDPTKVTRTALQNAASIAGLLLTTEAIITDAPEKDKPAAPAPGGMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR89</accession>
    <name>A0A139SR89_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="14" type="ORF">AXK12_02445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02445"/>
    <dbReference type="EnsemblBacteria" id="KXU37024">
        <property type="protein sequence ID" value="KXU37024"/>
        <property type="gene ID" value="AXK12_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="13">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="12">
        <location>
            <begin position="502"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXU37024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="625" mass="69123" checksum="C254878B128BF63E" modified="2016-05-11" version="1">MPAAQAALQPPSFNLANELDAALRQAATTALRDEPTQPKDELTTGALQEGKESQPPTLEGANEFCPELRPADPRHGDFQANGVLPYAKARKQNPRALAEKLVAALPDSLRERFDIAIAGPGFINFTARPAALLDWLAHYDSGARLREGAASTHGGERTIVDYSSPNTAKQLHVGHIRSMVIGEAICRLLEFCGAQVIRDNHIGDWGTQFGKLIWGYKTLLDAEALARDPLEELERLYKAADAATKADPAILDAARAELVKLQSGDAENLALWRQINATSSTAFQQIYQQLDIRFDHELGESFYNDKLARIYTELQDCGLATESQGALVVFHPEHPRFAKQPFIVRKSDGASNYATTDLATMLYRTEHFEADTIIILTDTRQTDHFEQLWLTTQKWYAAKGYRLPEFEHVSFGAILGDDGRAIKTRTGDPIRLQALLDEGIERAYALVSEKSPTLPETDRREIAAAVGLGAVRYADLSQNRSSDYVFKWEKILSFDGNTAPYLLYAVTRIHSIFRKLGLDPYTNTASAATAAGAASAPETEHELALARKLLQLPAVLQTTTEQLRPHFLCTYLFELAGTFSSFYAAEKVLNDSPGIQARRLLLCARTLLFLETGLHLLGLKTLTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRA0</accession>
    <name>A0A139SRA0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_02530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000017">
        <property type="protein sequence ID" value="KXU36981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02530"/>
    <dbReference type="EnsemblBacteria" id="KXU36981">
        <property type="protein sequence ID" value="KXU36981"/>
        <property type="gene ID" value="AXK12_02530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="84"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="546" mass="61492" checksum="87531E856451FA56" modified="2016-05-11" version="1">MRFALVAALTSLSLGLGGCDGERGQEETASRKAVDSRAPKRVFRVGNGTEPQDLDGQTVTGVPEHKIIMALSEGLLGQNPHTLEPIPGMAERWEVSDDGLTYTFHLREGLKWSDGEPLSAAELVASFQRILSPALAADYAYLVYNFVEGARDYYEGRLSDFAQVGFSAPDARTFVVRLKNRTPFLLKMIAGHYAWWPVPVRVIAQHGAVDQKRTAWTRPGRFVGNGPFRLKEWSPNQRIIVERNPHYWDAATVRLDEIHFYANDDVATAERLFRTGKLDLTEGLPSSKIAPYARDQPEVLQRDPLLALYFYRVNVTRPPLDDVRVRRALALAIDREALVRHVTRGGEVPAYAVNYPGTAGYVPEARLSGTLDDARALLAEAGYPSGRGLPKIELLYNTSESHREIAEAVQQMWKSTLGVEVELVNQEWKVYLDRQNTGDFMLQRGGWVADYVDPHVFLEIWETGNGNNKTGWGSPDYDALLHAALAAQNDEERYAYYQQMDALLVEELPIIPVYYYVKKGLLSPRVKGYYPTLLDIHPYKFIYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRE3</accession>
    <name>A0A139SRE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711027.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02180"/>
    <dbReference type="EnsemblBacteria" id="KXU37156">
        <property type="protein sequence ID" value="KXU37156"/>
        <property type="gene ID" value="AXK12_02180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="3">
        <location>
            <begin position="271"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="4">
        <location>
            <begin position="375"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="668" mass="72161" checksum="4167FF7B12F86F97" modified="2016-05-11" version="1">MTTLIEKIEAAAAAQKLLPSSLENLKTFLEAGLPEWARSSIAELVEAGEWAELNDRFYTFIAFGTGGMRGRTIAQVPTRAELGEAGVDKPAQAAIGSSLLNDFTLLRAVIGLYRYTARYSAEQGERAGLQGQARQSKGAAAPRLVIAHDVRHFSRHFCELAASTWVKLGGEAFIFDGPRSTPQLSYTLRAQQAHAGIVITASHNPPHDNGFKAYFDDGAQVVPPHDSAIVAEVAAVPLAELSAYLEKDLSRVVTLGAEADTAYRRAAHTALLDAQVLRREKLRVVFTNIHGTGAITSVPLLEEAGCEVITVPEQLGFDARFPSVKSPNPENAEALAMGIALAESRGADVVMATDPDCDRMGVAVCNRTGQMELLTGNQIGALLAEYRLGKYKALGLIPAEGSERVCLIKTFVTTGLQDAIGAAHGVKVINTLTGFKWISAKLRAYEDKLREALAEQGAGELDFDASSFAERARLLQTHSSFVTFAAEESYGYMPNDLVRDKDGNTACLMFAELCAALKVRGLTAGEALDELYLRHGFFLEGTVNLFYEGASGKAKIDRILASYRESPPTGFGDLRVTQFDDFGRQDFRDADGELIPKQDLYFVTLSNGYRFAARGSGTEPKMKFYLFASERVGSADALSHVKAQTRATLEALAAKIEADARSRAGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRJ3</accession>
    <name>A0A139SRJ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="5" type="ORF">AXK12_02155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711021.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02155"/>
    <dbReference type="EnsemblBacteria" id="KXU37152">
        <property type="protein sequence ID" value="KXU37152"/>
        <property type="gene ID" value="AXK12_02155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="401"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="458" mass="48430" checksum="42EEC711FB7CC21E" modified="2016-05-11" version="1">MRTEKDSMGEMAVPDDALWGASTQRAVLNFPISGRPMPEGFIRSLGLIKEAAALVNESLGRLSAEKSALIRQAAGEIIEGKLSAHFPVDVFQTGSGTSSNMNANEVIARRASQIAGSPGAIHPNDDVNMGQSSNDIIPTVLHISAALALKNDLLPALGRLREALAQKSAAFAHIVKIGRTHLMDATPLTLGQEFSGYVAQLRKSEQRVERAIEVLCELAIGGTAVGTGINSHPKFAPQVCAILAEKTGIAFREADNHFEAQAGRDDAVEVAGLLATIAASLTKVANDIRLLSSGPRAGLAELRLPATQPGSSIMPGKVNPVMSEMLVQVGLYVQGLAQTVVGCGRDGHFELNVTIPLIAHCLHESIQCLANGARVFAEKCVEGLEADEARCRELMERSLMLVTALNPFIGYDAAASVAKEALAEGKSLREVVLGRGLMDAETLERALEPLAMTRPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRL0</accession>
    <name>A0A139SRL0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_02230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711035.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02230"/>
    <dbReference type="EnsemblBacteria" id="KXU37081">
        <property type="protein sequence ID" value="KXU37081"/>
        <property type="gene ID" value="AXK12_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="412" mass="46727" checksum="DFD8040272C56F27" modified="2016-05-11" version="1">MTVASAPHTPNPSLLHNSEPPSPKLSDLEIKDAHLIFESVWHELEEQLGRQELRFPKEIILLGGAPGAGKGTNTAFITKARGLTCPPIVVSALLDSPEAQRLKNTGHMVGDREVIGLILHELLKPIYRDGVVLDGFPRTLVQVECLKLLVDKMHQLRHEFYGTPLGIHFRQPTIHIMVLFVDEKESIARQLKRGRETREHNEEVLRTGVGTLWEDRATDHDEALAQRRYRVFKEQTWEALQSLQEIFHYHFINAQGSFAEVEENITTELAYQSTLELDPQTVDQLRDVPVASEIIIHARQELVKRLDGYAMEQPKLFASVVSFIGQKVMPIVIRHAISGTAIINTEDTVLDDPLALSMLIDVFSERGYHATIDLHRIEVPERVDLATGQIHCRTKKVYRISIRFQGSQIRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRL3</accession>
    <name>A0A139SRL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000012">
        <property type="protein sequence ID" value="KXU37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711018.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00020"/>
    <dbReference type="EnsemblBacteria" id="KXU37172">
        <property type="protein sequence ID" value="KXU37172"/>
        <property type="gene ID" value="AXK12_00020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299391" evidence="3">
        <location>
            <begin position="27"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="101"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="559" mass="59568" checksum="82A569CE6345AFB1" modified="2016-05-11" version="1">MKPLSSFRLLLASLALLAPLAPPALAAAKQIYQSPMHPWITSDKPGRCTICGMPLVLVTLDDDPAANPSTANDSASPLVTLSATQHSVSGIQTAPVIRGTLTRTLRVNGSIEDDETRHRILAARVPGRVETLHVNYVGAEVRAGEPLAVLYSPEVLTAQRNYLEHLRAGEAFAATDRAAARERLLELGLTAAEIRALETTHSATALHTVRAPLSGTVVARAAYEGQYVSVNDTLFELCDLSQLWFIFDLYEPDLAWVSVGQEVEVSLLSLPGEVLRAPIAFIDPNLAPVTRTARARVVLDNAQGKLLRRQTATALLRAATPDRLLVPRTAVLQHRGEAIVFVEEAPRRYAARAVTLGQNGEGQVEILSGLAVGERVVTEGGLILDGQAQLAAVNASHSAQPENAASSAQPDAPAQSHISPTPLNEATRTALLAAALAAADAAHALAADDLPGYQRTLPALRETSRAYSATHPDDELATLTSALAEGADLKQARDAFEPFSTALADLARAAQLHHGKAGLHLFQCPMTPVLGTGRWLSRSAELRNPFFGELMLECGEQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRP5</accession>
    <name>A0A139SRP5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutL</name>
        <name evidence="7" type="ORF">AXK12_02095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711008.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02095"/>
    <dbReference type="EnsemblBacteria" id="KXU37228">
        <property type="protein sequence ID" value="KXU37228"/>
        <property type="gene ID" value="AXK12_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="210"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="492"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="678" mass="73117" checksum="FCCFC360F0ADB203" modified="2016-05-11" version="1">MAEKVRILPDRVANQIAAGEVIERPAAVIKELVENALDAGATRIEVEFRHGGRALMRIEDNGHGMSQDNALLALERHATSKIAEAADLDQIGSYGFRGEALPSIASVSRFELQTRERGAEEGTEILINAGRIVHVRECGRPVGTRIVVTHLFNSVPARRKFLKTDQTEAAHIIQCVRLYALASPQAAFTLIEDGRVIFKSPECATLAERVAEIFGRQTAEALVPIDASEGSEEAGARTAGAGGPMRLRGLIGRPGVGRATRHEMVIFVNQRPVNSRTLNYALIESYHESLPKGRYPLAFLFFECAPAAVDVNVHPAKREVRFRSEPAVRGFVIRSVLARLRELGAEFGSPASGEAQAPPTPAAAVPVLHSAALPQTGGRVIALSGEKAALPAPQLSPFTAPRTVWPAGAVPPSTAGKLQPFAPVSAYELGEAQRLGHAASRRGGRGESPDGAAKSALLNKSSLDTALASAAQGPGHSITGSVPNTNTLRLRFVGVVHGAYALFETAAGLLLLDRRAATERVWFERLQAQFRNASVPSQRLLLAVPLELDPIATALLLDRLSFLAEHGVEVNEFGRNFFRIEAVPTWMEPAEAEGFVRDFLGQVREGRFHENNLDLMREELARLAISRAVRLPTNPSEEELRALLDELFATSHPLTSPAGRPTYVELSHTALARLLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSA1</accession>
    <name>A0A139SSA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710937.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37423">
        <property type="protein sequence ID" value="KXU37423"/>
        <property type="gene ID" value="AXK12_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="86" mass="9562" checksum="B86FAAE740E380F4" modified="2016-05-11" version="1">MIPQPNQRSPLGPRAGLLGIGFDNKDGHKRITTGEEFAIIGGSSETHDRMTETLVKTFEELKKRSKKLQQVGPKELAEIIHKATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSB6</accession>
    <name>A0A139SSB6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710950.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01745"/>
    <dbReference type="EnsemblBacteria" id="KXU37437">
        <property type="protein sequence ID" value="KXU37437"/>
        <property type="gene ID" value="AXK12_01745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="199" mass="22504" checksum="F12F845CD5D6DDF2" modified="2016-05-11" version="1">MPPSRPDTVAPPSPDGERLHPHVESVLVTEEQLRTRIAELGREIRVVYGPDEELTLISIINGALVFTADLLRELENPIRLDCIRISSYRDAVESRGVPQVLGKLTLDIAKKHVLVIDDILDTGKTLDFVTRMIRKHGPTSLRVCVLLDKKDRRTVDFEADFVGFSIPDQFVIGYGLDFAEQYRNLRYIGTLKPQFQHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSC3</accession>
    <name>A0A139SSC3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amino-acid N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ArgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710967.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01900"/>
    <dbReference type="EnsemblBacteria" id="KXU37380">
        <property type="protein sequence ID" value="KXU37380"/>
        <property type="gene ID" value="AXK12_01900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01105">
        <property type="entry name" value="N_acetyl_glu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000423">
        <property type="entry name" value="ArgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01890">
        <property type="entry name" value="N-Ac-Glu-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="295"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="448" mass="48711" checksum="2BC81728CB09D4ED" modified="2016-05-11" version="1">MSATPALATAKAAALAATIKPTDLRGILQYVPRFQGQIFVIAFDGSIVADDNFGNLLVDVAVLRSLGIKVVIAHGIGQQLRELAQLRSVPLSDVEGTGITDAPTLDLAIRASARVSHLILEGLAQNNLKGASTNAVRALPVGIIRGIDQQFTAKVDRVDKDFLHSLINSQVIPVVSPLAFGPDGRSLRVNSDLLAAELAKALHATKIIYLTPHPGLEIGGTVQPQIAIEALRAQLDRAPDQLAEQCRSKARHAVYAIDNGTPRVHIVDGRLLDGLLNEIFSGEGVGTLIYGNDYQQIRKANRRDVRFIYSLTRSAVKREELVQRTQQAIDKTIDQFYVFEIDENIIACVTLILYPPDTAGAPKLAELGALYVLPFYQNRGIGRKLVEYACLMAKKQGASKILALSTQSYGFFTNNLGFSEVDKSILPEARLRQHEESGRNAKVLARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSG0</accession>
    <name>A0A139SSG0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37432">
        <property type="protein sequence ID" value="KXU37432"/>
        <property type="gene ID" value="AXK12_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="113" mass="12423" checksum="9EE6696A01CC6B14" modified="2016-05-11" version="1">MEVRKIAIDNSTLSVLAVGVALFALAFGAFTHLSGRIESLDAKFDARIDKLDAKIEQQAARTDARIDRLDAKIEKVSSELNAKIDRVDAKIDAVNARLDRLFEVIASPGRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSG4</accession>
    <name>A0A139SSG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710922.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01665"/>
    <dbReference type="EnsemblBacteria" id="KXU37515">
        <property type="protein sequence ID" value="KXU37515"/>
        <property type="gene ID" value="AXK12_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299404" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="13481" checksum="A58F534987B42895" modified="2016-05-11" version="1">MKTLSSLLLLVALFFAAPASSLQAAEDLAAVRTRMEQRLPTIDELKAQGAIGENNRGLLEVRGGGGNASSVASAENRDREIVYAEIAKKNNTSADQVGRARARRIAANSAPGVWLQRDNGEWYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSX0</accession>
    <name>A0A139SSX0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710907.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37656">
        <property type="protein sequence ID" value="KXU37656"/>
        <property type="gene ID" value="AXK12_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="76" mass="8380" checksum="42ACB0BE3CB4475E" modified="2016-05-11" version="1">MAVIPLTLTISLCLVFTFVVFFLRETSRKHYSDAQRDALMPLADETPLTAIAKPSTVPTAQSARGQEMHTHAKAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST71</accession>
    <name>A0A139ST71_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">AXK12_01140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710824.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01140"/>
    <dbReference type="EnsemblBacteria" id="KXU37798">
        <property type="protein sequence ID" value="KXU37798"/>
        <property type="gene ID" value="AXK12_01140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="342" mass="37001" checksum="7B5B6376DBC1F617" modified="2016-05-11" version="1">MPAKIYTDKDADLGVLKNKTLAVIGYGSQGHAHALNLKESGCKVIIGLYAGSKSRSVAEEHGFKVYDTAEAVTKADVIMIALPDMVQADVYESDIAPNLAKGKTLLFSHGLAIHFDLITVPKGVDVIMVAPKGPGHIVRRLYVEGKGMPALIAVAPGSSRDAKKTALAWAKGIGSTRAGVLQTTFKEETETDLFGEQAVLCGGASALVQAGFETLVEAGYQPEMAYFECLHELKLICDLMYESGIAGMRFSISETAKYGDITRGPRIVNKQTKAEMKKILKEIQTGKFTKEWVKEHKGGLKNYSALLKAGEKHQIEKTGAYLRGMMPWMSKKNIKGAQASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST96</accession>
    <name>A0A139ST96_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710823.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01135"/>
    <dbReference type="EnsemblBacteria" id="KXU37797">
        <property type="protein sequence ID" value="KXU37797"/>
        <property type="gene ID" value="AXK12_01135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="156" mass="17246" checksum="F27151228CC7CBEE" modified="2016-05-11" version="1">MRHTISALVENKFGVLARVAGMFSGRGFNIDSLNVAPTHEAAFSRITATLKGDDHALELCIKQLRKLVNVVEVTDFAEGSAVTRELVLVKVRADARTRSEILQIKDIFRAKIVNMSHDDLVIECTGDDEKVSAFLNLLDPFGILELARTGRLALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STD1</accession>
    <name>A0A139STD1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_01390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710865.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01390"/>
    <dbReference type="EnsemblBacteria" id="KXU37837">
        <property type="protein sequence ID" value="KXU37837"/>
        <property type="gene ID" value="AXK12_01390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU37837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="156" mass="15957" checksum="EC14E4520605CB73" modified="2016-05-11" version="1">MTAILICFAIGSLLIGFEVVVPGGILGTIGGVALLCAVGLSFHDYGVNGGALAFVAALVLVVAVLFIEFKILPKTALGRSLFLEGSVSGTATAEPQQSLVGARGEAITTLAPSGYVLIDGRQHEAFSRSGFISAGKPVKVVAAESFRLIVILENTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STL9</accession>
    <name>A0A139STL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00815"/>
    <dbReference type="EnsemblBacteria" id="KXU37937">
        <property type="protein sequence ID" value="KXU37937"/>
        <property type="gene ID" value="AXK12_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="412" mass="46102" checksum="51324A0C45DF853B" modified="2016-05-11" version="1">MVKIQPLIDGQDWNGVVELMQSILRYAAPNSFDQALANDILSKAYLQLGDYAASLPPLEAAYNSAVANGFFEERSQLERLYLLAQIYYQEASTVKVPAAQAQLFSKALGYIEKWINSQESPSADGRMFYISLLYNQAVLDPQKIDMGFLKKAQQQCQEALQAELAPKEGLYLILLATLQQEGDLARTTDLLELLAKQYPAKQTYWQQLFATYSNLSAEAKRPEEAESYNLRAIVTLERAQALGFMNTPKDNYNLVGIYFNIGQFGKATELLHAGLRSGAIDADIKKWELLAYSFIQVNRELTAIEVLKEAIQQFPESGQLDNQVAQIYYSLNQSEESYRYLNSALAKGGLDNVGAVHYFKAYICFELQKLDEALVAINLAAELQRTENAQLPGLRQAIQDAIANREAATKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STR2</accession>
    <name>A0A139STR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710810.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01075"/>
    <dbReference type="EnsemblBacteria" id="KXU37979">
        <property type="protein sequence ID" value="KXU37979"/>
        <property type="gene ID" value="AXK12_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="265" mass="28769" checksum="3C130785BDB3CB82" modified="2016-05-11" version="1">MHDSQAQPFVVRFMPSLAQLLATHGHLLVLDAASACVQVGWLSAHEATWASSTDEAGKALFCGIDTVLNAAPNRSIATAGAFLFCEGPGSILGIRTAATAIRTWLTLHPQTPAYSYQSLALLAHGLGDATLTLIADARRDHWHVQKLGQALRQVPSSGLRHAPNAENPEPSDQSTLTRANEPLQKKQVYGMPEGFRHWTTPPPNLTRVPYDLETLFANERVQAAQLFTPAHEPDAFLHNEATYKTWSPQIHRPPAALNTPAAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STS2</accession>
    <name>A0A139STS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_00995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710796.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00995"/>
    <dbReference type="EnsemblBacteria" id="KXU37965">
        <property type="protein sequence ID" value="KXU37965"/>
        <property type="gene ID" value="AXK12_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299428" evidence="2">
        <location>
            <begin position="28"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="310" mass="32236" checksum="C65CDE443CDB3C52" modified="2016-05-11" version="1">MATHVKLRLGLALTALTAALGTGTAQAQSPMIYAPGGGGIDAPITTNLVSKLYAVDVEGEVYVENSGLIIPLAAREIYVAQGSTVYTSEESTASLVISNGTGIFLSESSRMTVTRAEQEPFQGERSDMINEPSVSNIQLKHERGVMGICTSRLLAGTLLEVVTDEFTTRIVDGKLVYERGPEGSSVTLVGGDASLQSGQIWYENEGRDLKVRHKLFFPADGSEPIDTELSGQELAEMEGIVTIACLARRGVYFDVLGDPVASDIIDTPDQAEGITGTPTTPGPGGGGPGGGGGGTTVEPPPNTVSPANIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SH55</accession>
    <name>A0A139SH55_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000066">
        <property type="protein sequence ID" value="KXU33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00625"/>
    <dbReference type="EnsemblBacteria" id="KXU33898">
        <property type="protein sequence ID" value="KXU33898"/>
        <property type="gene ID" value="AXK12_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01821">
        <property type="entry name" value="Rhamnogalacturan_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PTHR43695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="36"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="31062" checksum="15E478E9BCCA19E7" modified="2016-05-11" version="1">MRFPAFRIVLILVALIGLCLGLLLRENDKPRILIAGDSTAQPGTRRHQVYGWGEPFADLFDPTKAKVINLARGGYSSRTYITGGLWAILLGKVRPGDLVLIQFGHNDGAPGSEGLRMEPAHLLRMPHSLPGTGEEVVEIESAATRDRERVHSFGWYLRKMVADVRARGGRPILLSPTVQNRWTEQGDIERDNPYRAWTCEVAEQAAVPFVDLAQILADDYQRRGRESVAELFSRDTLHTNTRGAAHTAALVLAGLKGLRGEAAIPDLDTLLSEKGLEILATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHF5</accession>
    <name>A0A139SHF5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_08255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713296.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34012">
        <property type="protein sequence ID" value="KXU34012"/>
        <property type="gene ID" value="AXK12_08255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="33230" checksum="19F6C34CD7862858" modified="2016-05-11" version="1">MQNSRPTLARRLLLWCSALCLLVLLPGCNDVVLNNLTPSSLTENPSRIYTITLRVDQKRKRIVPGSVQPYLIIDGERHLMQPSRVGAEFYEFDYAMAPGRSEIAYYFLVNYEVRSNDRNVPGEAYTELARATVTGRYVYSLEANRGPVGARISVIGRGFSPQDSVTFDGQPVRSHYESISSLSFFVPALEIGRDYQVALVGARGATPLGSFRIDGSKLLVTPSALSLRSGSVQSLTFTLPQPAPLGGLLLDVTTDIPSSVIMDEVIVPAGQSSVTINVQGGSPGTGSLFLRGYDSGELTIPVRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI03</accession>
    <name>A0A139SI03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF3485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AXK12_07845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713152.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07845"/>
    <dbReference type="EnsemblBacteria" id="KXU34179">
        <property type="protein sequence ID" value="KXU34179"/>
        <property type="gene ID" value="AXK12_07845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3485" evidence="11">
        <location>
            <begin position="337"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="550" mass="60395" checksum="553D1DC16600880F" modified="2016-05-11" version="1">MTFASGISIFQKLPLLLRISLVMLLCLLGGNIALLWPHWRTNPDLSHGFFVPILFFLLLREGMQQPRPRYLPAHWLKTLATLGLLTGGLLAILAGGLYSAAVGWSHSLVVFTMTAGGCMLLCATLLVLSDTRWRLVPFCWPVLVGIGLWLLCAPIPPGTYSRLIVALQLMVTEHVITALHLLGIIATQQGNIIELATTQVGIEEACSGVRSLISCVFAGFFFSASLVRQTWARVLIIGLSAPLALVMNFLRSLTLTLMANAEMDITGTLHDVTGFAVLGITAALLSGLAILLDRPGPEALADSEKPSSEAAPARDKPARTPRLFPKLDSLGLASGLGLTCLLVLGFILLTRAPEESAQQPDLLELLPSRAAGWQVNANPKLYQFSGVLQTENLAERTYRKRTEDGRDLQITIYLAYWEPGSTSVSQVAMHTPDACWPGAGWTLVEDGTRPREALRLAGDQSLPTAEARHFKNGNYPQYVWFWHLYGGRPIAYEDPRSPVRLLKQAWQHGFSRNGSQCFIRVSSNYPWETLKDEPLLNEVFENLRPLGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI06</accession>
    <name>A0A139SI06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_07820</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the biosynthesis of agmatine from arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713146.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07820"/>
    <dbReference type="EnsemblBacteria" id="KXU34176">
        <property type="protein sequence ID" value="KXU34176"/>
        <property type="gene ID" value="AXK12_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040634">
        <property type="entry name" value="Arg_decarb_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041128">
        <property type="entry name" value="Arg_decarbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17810">
        <property type="entry name" value="Arg_decarb_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17944">
        <property type="entry name" value="Arg_decarbox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001336">
        <property type="entry name" value="Arg_decrbxlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01180">
        <property type="entry name" value="ARGDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01273">
        <property type="entry name" value="speA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="13">
        <location>
            <begin position="91"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarb_HB" evidence="14">
        <location>
            <begin position="372"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarbox_C" evidence="15">
        <location>
            <begin position="582"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001336-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="651" mass="73530" checksum="D9A04660EF5701E3" modified="2016-05-11" version="1">MKRKPAAHWSAAKSEELYGFKRWGDGHFAVDNEGFATVQPLGDERKIRILDVVREAVGMGLSAPMVIRFQDLLRNRVSQLNEVFAKAIKEEDYPGRYRGVFPIKVNQLREVVEEIIEAGRDFDYGLEAGSRPELMIALAMHEGTKRLIICNGYKDLDYLRLALLGRKLGKQVIIVVEQLSELDDIIALAAETGVEPMIGFRAKLQTRGEGKWATSTGDNAKFGLNTAEILSACEKLKASKLSDCLRLVHFHIGSQVPNILTIKNAVTEASRFYCQLHKMGFPMGLLDVGGGLGIDYDGSRTNFESSMNYTMAEYARDIVSNIREICTAEAVPPPDIVSESGRAVVAPHALLVVEVVERINKRESLGKHRQPAEKHAIVSSLEATLQNRPRLGKLERFHDAVQKKAEAFSLFNLGYLDLENRAAAEQLFWQICEQIAKEIKKTGYVPEELHELNKLLADQYVCNFSVFQSLLDHWALGQLFPVAPLHRLTEKPSVDAILVDITCDSDGKISRFIDLQDVQDYVPLHPLGNKPYYLGIFLTGAYQDIMGDMHNLFGRVNEVHVFLEDDEEDGFYIEESISGSSVGEVMEDVQYQQADLCRRMKRQIDSATRKDVLKPREGIRLLELYERQLRNKTYLGTEPFSTRPKRKVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI47</accession>
    <name>A0A139SI47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_07740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713124.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34164">
        <property type="protein sequence ID" value="KXU34164"/>
        <property type="gene ID" value="AXK12_07740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="52268" checksum="CF3D8735B6A14D6C" modified="2016-05-11" version="1">MPNFLKTLTDRFFSPGALVIVSLAVLSSLVVILLPVEKPEGIQYWVFSSHHGEARVEDIAEWNRSHPDKPVVMKLMHMAAIERGMLSGFLSGTPLADIIESNHDVYPKAFLGPLDQIGFLDLTDRLHDEGLYEQFNAPSFSTMTSRGRIFGLPKDVHPVLLGYHVDLVEEAGIDVNEIETWEDYFRVMRPLMVDRDGDGRPDRYLLNLSETDTELLLLLMMQNDGVFFDENDVPIFANERNARSLATIITWLTGPDRVAAPVTSGPSGFRQHLDAFVVGNLFPDWVYGDWKINNPAMAGRIRLMPLPAWEPGGRRTSVMGGSNIGINKHSPYVEESWEIAKMLYTSARGAEKIWQTTNILSPVKTLWDEPFYHEPDPFVGGQRAGTLYIEQAPHVPERPSSPYKNTAFGQVSAAAIALRAYAEQNSIYEVDRLIPEALRLLKERESALKRLISRNVFQEGYLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI51</accession>
    <name>A0A139SI51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-glucosidase/alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_07715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713115.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07715"/>
    <dbReference type="EnsemblBacteria" id="KXU34160">
        <property type="protein sequence ID" value="KXU34160"/>
        <property type="gene ID" value="AXK12_07715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="136"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="433" mass="47734" checksum="089101F84A466697" modified="2016-05-11" version="1" fragment="single">LKAKVSSTLNRRTALRGANYVFCVVRTGGLEAFTHDIDIPLKYGIDQCVGDTLCAGGIMYGQRGIAVLLDICKDIREVAAPNCLLLNYANPMAMMTWAASVYGGVRCVGLCHGVQGGIHEIARAIGASAKDLDVICVGINHQTWFTEVKHNGVDVPMDRILAGFENHPEAARDEKVRIDMMRRFGYFSTESNGHLSEYLPWYRKRPAEIKKWIDTSTNAWIHGETGGYLRYVTEGRHWFEEEFGEGRLPATLEFTAENRSPEHGSYILEAMETGRVYRGFFNLVNRNTISNLPADAIIEAPGFVDRFGFNMPQFGDLPLGCAAVCNASISVQRMGAHAAATGDINLLRQAMLMDPLVSAVCNPPEVWQLVDEMLVAQAEWLPQYSEAIKGAKARLAKGPLIKTKAGYKGAARKKIRTTAEIRAQEKGNPRGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIC6</accession>
    <name>A0A139SIC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712965.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07325"/>
    <dbReference type="EnsemblBacteria" id="KXU34283">
        <property type="protein sequence ID" value="KXU34283"/>
        <property type="gene ID" value="AXK12_07325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="256" mass="28119" checksum="2F021B8027A3B903" modified="2016-05-11" version="1">MSSNTAAPIVEFSALSHRYKNGDSSLVLDRLSLKARRGEFISFIGPSGCGKSTLLRLIARLLPVTTGTLQLAPHTEVGFVFQDPTLLPWLTVEANVALPQTLRSHSTKQRPQTAKALLALVRLTEHSRAYPHELSGGQKMRVSIARALTLSPQLLLLDEPFGALDEMTREHLQEELLALHAAQRWCGLFVTHSVAEAVFLSDRIFIMSANPGKLVHEVSIKLPSERDADTRLSPAYQAQVAEVSRLLRNVETATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SID7</accession>
    <name>A0A139SID7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">AXK12_07460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000059">
        <property type="protein sequence ID" value="KXU34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713011.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07460"/>
    <dbReference type="EnsemblBacteria" id="KXU34306">
        <property type="protein sequence ID" value="KXU34306"/>
        <property type="gene ID" value="AXK12_07460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="144"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="542"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="598" mass="66105" checksum="37ACB35566BFCAF1" modified="2016-05-11" version="1">MKRTHHCGQLTKTDLGASVSLAGWVDSIRDHGGILFIDLRDRKGITQVKFDPQDDAALGEAAAQLKPESVIAVSGTVALRPEGTANASLPTGEIEVNATALEVLNRSEPPPFPLDDAGGDKVSEDLRLSYRYLDLRRPKMRRNLEVRHRATKAIRDYFDSQEFIEVETPALFKSTPEGAREYLVPSRIHPGQFYALSQSPQQFKQILMVAGVEKYFQIARCFRDEDLRADRQMEFTQVDVEASFVTREDIYALFEGMLKKVWRDVLGTDIPTPFPRLPFADAMNRYGSDKPDTRFALELVDFTELFKTSSFKVFASTAASGGAIKAINVKGLADLTQGELKALEDAAKALGAKGLAFIKVEGGEWKSPIVKFFSEAEKAELSARLSLEEGDIVFFAAAEWERACAILGRVRLDAAQLLVKRGKLALRDDDWKFLWVVDFPLMSYDEERGGYAATHHPFTAPVPEDASLLVSDPKAVRGQHYDIVLNGVELGGGSIRIHQPALQKQVFEDVLKIPADVVESRFGYMLRAFTFGAPPHGGIAFGLDRIVALLCGTQSIRDVIAFPKTQRGQDLMAQSPTPVTPKQLKELHIATAVPVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIM5</accession>
    <name>A0A139SIM5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_00495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712918.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00495"/>
    <dbReference type="EnsemblBacteria" id="KXU34425">
        <property type="protein sequence ID" value="KXU34425"/>
        <property type="gene ID" value="AXK12_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="14"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="370" mass="41042" checksum="0D6858B6ABC2C01D" modified="2016-05-11" version="1">MQLGPYTLSSNLFLSPLAGYTNLPFRLTLRELGGLAWTTCDLVNARSLIERTPAALKLVASSPEDRPFAIQLFGNVPEEMREAARICQELGAQSVDINMGCPVKKVVRVGGGSAMMTELRKTAALVRGMVEAIDIPITAKMRLGWDDENLSAPELAAVLEEAGVAAIFVHGRTRAQGFSGRVNLSGIRAVAAAVRTIPVIGNGDVTTPQAAKRMIDETGCAGVSIGRGAFYDPWIFRRTDHYLRSGELLPEPDFGERVRVMRLHFERYCDFYGEAHGARLFRKVAPWYAKRFGPAKPFKQDIITINSRADFEAVLTRYIDWRSQFCDEHGELLPRYALDPLRASFMDAETDTRTPERTAIPVPRGPIEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIP1</accession>
    <name>A0A139SIP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712877.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00365"/>
    <dbReference type="EnsemblBacteria" id="KXU34406">
        <property type="protein sequence ID" value="KXU34406"/>
        <property type="gene ID" value="AXK12_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="165" mass="17517" checksum="22FA8A507414C1EB" modified="2016-05-11" version="1">MTDEVTALIPHRPPFLFVDRILSADTDSLVAERTWAPEEDFYRGHYPEAPITPGVLLCEAVFQTGALYMAKRAQAEAAAAGQGGKSEGVPLLAKISDVRFRSPVFPGDVVQIEVRKKETLGGFTMMDGAIRKADGTRVLNVSFAVAWKTPEGGGGGAGALGGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIR2</accession>
    <name>A0A139SIR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_00480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000056">
        <property type="protein sequence ID" value="KXU34423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712914.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00480"/>
    <dbReference type="EnsemblBacteria" id="KXU34423">
        <property type="protein sequence ID" value="KXU34423"/>
        <property type="gene ID" value="AXK12_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="617"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="660"/>
            <end position="667"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU34423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="964" mass="104977" checksum="05C6621318534EA6" modified="2016-05-11" version="1">MQAATHIHIKGAREHNLRDLELRLPRGRLVVITGPSGSGKSSLAFDTLYAEGYRKYIESLSVQARAVLDQLKRPDVDFIHGLSPVLAIDQRGSAGAGGGGSSRHTIATTTEIADYAQLLWALAGEQFCPKDGGRVVRRSLDDNIEQVLKTCAGQRVMLLAPALCAKPSVLREELPRLRQRGFQRVRIAGEIADLDDERDFIPKGQGTRELAVEIVVDRLVVSAEQRARLADSLELCFREGSDRAIVLAQADRDSDEWREVPLSQHLACEVCGDVFEKLTPQHFSANHPKGACPTCGGLGRKLRFAPELIVPDSTKSVRGGAIKPWRLGGKNLIIRHNALLKQLAEQLPFDADLPWAELPETQRQVILHGAGEREFAFKLRRMAGGRTPQSMPFAGVIADLEQSFRETKSEGFRARLTSFMVSGPCPECAGTKLNARSEAVRLLGKTYPDFLALDVEEAAAFAGELEARYAADGGLDELSRGIAQRLRFLLDTGLGYLSLGREQATLSGGEAQRVRLATQLGMGLMGVIYVLDEPSIGLHPSDNARLLRQLAELRDRGNTVVVVEHDEDTMRLADELVELGPGAGKEGGQILFQGTPTECLALPPRQSPTADYLSGKLRIENDAGLRSPSGAWLSVREAREHNLKGIDVKFPVGLLTCVTGPSGSGKSTLVNDILAQAAARKLNRAKTLPGLHARIEGLELFEKLVLVDQSPIGRSPRSNPATYVGLMDLLRDLFAQVPLAKVRGYKASRFSFNVRGGRCETCQGDGLIKLDMQFMADAYAPCPSCGGRRFNRETLEVRFHGHSISDVLDMTVQEAIALFRNIPRIIDKLATLEAVGLGYLTLGQAAPTLSGGEAQRLKLSLELSKRQQGQSLYILDEPTTGLHWVDIQRLLDLLFKLRDAGNTIIIIEHNLDVMAVADWLIDLGPGGGKHGGELVYAGPRSGIEAEPRSTTGAALARLEHKENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ02</accession>
    <name>A0A139SJ02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lpxD</name>
        <name evidence="8" type="ORF">AXK12_07120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712794.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07120"/>
    <dbReference type="EnsemblBacteria" id="KXU34516">
        <property type="protein sequence ID" value="KXU34516"/>
        <property type="gene ID" value="AXK12_07120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="346" mass="36317" checksum="2DE41ADC2E56DDB8" modified="2016-05-11" version="1">MSISLTPEELRAITGATRTSGQTHATITGIASLEAAEAGDLSFLGNAKYRTAVPSSRASLILLPEDYEGSEPGEGQCYFFVKNPSAALASICSRIEQSLWPKPQAGVHPTAVVEAGAEIDPTATVGPLCVVEEGARIGARTHLQAQVFVGAGAQVGDDCWLMPHSAVSAQCTLGNRVRLHPGAVIGADGFGYEFVEGRHEKIPQVGTVVLEDDVEVGANSTIDRARFSQTRVGEGTKIDNLVQVGHNVVIGKHCILCSQVGIAGSATLEDYVILGGQVGVSGHLRIGKAAKAGGQAGVIADVEPGAFISGYPAMPHRLASRLQVLQRRLPDLFKRVDQLEQQLAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ11</accession>
    <name>A0A139SJ11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712809.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07155"/>
    <dbReference type="EnsemblBacteria" id="KXU34523">
        <property type="protein sequence ID" value="KXU34523"/>
        <property type="gene ID" value="AXK12_07155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299227" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="316" mass="34062" checksum="6FDD94292735C2D5" modified="2016-05-11" version="1">MKLFLTTLCIAAFATLARSAEIEVSAQVAQNIGLQTAVAELRPIERSVSALGRVEAEPGSLVAITSRVAGRVTALAVHDGQRVEVGDFLVEVESRVAAQTPPRLRFTSPIAGRVLEAEIPLGGAVEPADTLLTLVDLSEVDVVGEIHIRDLANVQLGQRVRVRSAAYPGEVFEGELKTIAANVDRQTGTRRIFVHTPNLQEKLLLGMRVQLSIVVEDQARAVVVPREAVRGEAGDFFVFRELPSAGGNAGLSASHERHYERTSVVVGLRDDRFVEIIDGVLPGDRIVTRGNYQLEYLEAARGEGSAAFDDGHGHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJA8</accession>
    <name>A0A139SJA8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000052">
        <property type="protein sequence ID" value="KXU34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712788.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07095"/>
    <dbReference type="EnsemblBacteria" id="KXU34626">
        <property type="protein sequence ID" value="KXU34626"/>
        <property type="gene ID" value="AXK12_07095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299265" description="Plug domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="550" mass="61112" checksum="5A26BC779CB9BE42" modified="2016-05-11" version="1" fragment="single">MNTPKICTPKKHPKLLPIALSLCTFALGSLHAQQSPGQDDEEIVRLSPFAIQERADIGRYQATESSSGTRVRMSLMDSSQSISVVTSELMQDIGTARLTDATKYVAGLSTYGAIPLVLDIMNVRGFIDFELTIDGFALSPASQDPIIVERIEFVKGPNAILAPQGLPGGVVNNISKKPLFTNKGYLSYQVGRYDANRAELDANYVVNDKLALRVVGAFTDADHYGQGVFHQNTTVMPMFTYRLSPTTEFTLQFQIQKVDAPAGMAPLSVYAVGRNNINLPEGLPRDFQYTGRNITSHQKSHNTRFFLTSQITDKLSMRVAGSWAVSDARSNGLGPSAPYLGQTGVVVDPIRLDPITGEWYWDGTFNDNPTYKLGGVKEWPLRMKGSFQNDFVYEHTAANWKSQTVAGYAFNYISQHFRQRNYVDDGIYYDFANNYTPPAYAFDPDIDWHFNVSERHRSNQVYIYEVINLFEDRLVLSGSLSQNRYASNVYNNQTGVRSDNRAEATLPSAGFVYKMTPGVSAFYGYSKQEVLVGGDPGLGIPAHTRPGRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJD4</accession>
    <name>A0A139SJD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pnp</name>
        <name evidence="9" type="ORF">AXK12_07030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712762.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07030"/>
    <dbReference type="EnsemblBacteria" id="KXU34688">
        <property type="protein sequence ID" value="KXU34688"/>
        <property type="gene ID" value="AXK12_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="635"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="743" mass="79491" checksum="80F7169FE5EAD4BE" modified="2016-05-11" version="1">MNQKHNVTVPGLGITFSTGTYASLANGAVNVCVGETNLLVTACVAQSTKPGQDWFPLTVDYREKYAAAGRFPGGYFKREGRPSEKEILTSRLCDRPCRPLFPAGFLNEVQIIGQLLSADQINDADISMVNGASAALAISDIPWAGPIGCVRVAEIDGQFVANPTIEQMFQSTLDLIYVGTERDMLMIEGSADQISEERFIEALEFGHQAIQPILTAIKELVAVAGKPKATFPLVKATDEARAIIERVASEERVTAAIFGHEKAVRAANIKALKDEAVAALTTELGADKFTEADVAIVFEDLQYKAYRKTVLERGIRSDKRDAKTIRPLSASVGVLPRVHGSASFQRGDTQNIAITTLGPTKEAQHLDALTGGVSSKSFILHYNFPPFSVGETGRYGSPGRREVGHGALAERSLVPVLPPEDVFPYSIRVVSEILSSNGSTSMASICGGCLALMDAGVPIVAPVAGISCGLMTTNKPDGSIDKWVTITDILGEEDHFGDMDFKLAGTTRGITGFQLDLKINGLPFEIAKTAIFQARDARIEILKAMLAALPAPRADLSAFAPRIQTIQIDPEKIGLLIGPGGKTIRRIVETTGAQVDISDDDSGKVFIYSNNADSMNRAVQEIDSLCGGGSQIEVGKIYTGRVTGTKDFGAFVECLPGKEGLVHISELADFRVRRTEDVVKVGDSIQVKCIGIDERSKKVRLSRKAALAELEAQNGSHAAPATEEPAATQNADNDTATEDAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJE1</accession>
    <name>A0A139SJE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">AXK12_07090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712782.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07090"/>
    <dbReference type="EnsemblBacteria" id="KXU34698">
        <property type="protein sequence ID" value="KXU34698"/>
        <property type="gene ID" value="AXK12_07090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="17701" checksum="9F18369D30F9AF7D" modified="2016-05-11" version="1">MAYSEILLVKPVDGLGGEGDQVKVRAGYARNFLFPRSVAVPVTKANRKQVEALKKRRAEREAQELAGAQELGKRIAAVSLAFAVKTGEGGKMFGAITATDIHDKLTEAGIDLDKKRIHLYTPAKTLGKHSVKVKLHPEVTIELDFDIVSENPIVDAEQAAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJH7</accession>
    <name>A0A139SJH7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000051">
        <property type="protein sequence ID" value="KXU34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07020"/>
    <dbReference type="EnsemblBacteria" id="KXU34699">
        <property type="protein sequence ID" value="KXU34699"/>
        <property type="gene ID" value="AXK12_07020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009978">
        <property type="entry name" value="Na_H_antiport_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07399">
        <property type="entry name" value="Na_H_antiport_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299289" evidence="2">
        <location>
            <begin position="26"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="524" mass="56246" checksum="694EA73AE20956A3" modified="2016-05-11" version="1">MKIGPALLTKLLCYFAVLAPLFLGAEVAASESEPHAAIAAAEFPREVASYVAPSVGSDAARAGVWAVLKARAAVEPFNVVATAIFALAVLHTFFTARFRRWAHAVETRYAARPRKRPRVVTDNDGDGRPDEVSFFGQVLHYLGEVEAVFGTWALVLFCAVVCDKGLDTAIHYFANRVNFTEPMFVVIVMALASTRPILRLAEQCLRVVARLGGETPLAWWLSILTVAPLLGSFMTEPAAMTIAALLLAKQFYALRPSKPLKYATLGLLFVNISVGGTLTHFAAPPVLMVAAKWGWGLGHMFLNFGWHAVVGIVVSNAVYFLVFRRELARLGAGASSGGSDTVKESESAPIPVWVTLGHLLFLGFTVWMAHHPVLFVGGFLFFLAFAQATAHHQSRIDLRGPMLVGFFLAGLVIHGGLQAWWIEPVLGSLGRLPLFASAMVLTAFNDNALITYLATLVPNFSEELRYAVVAGAVTGGGLTVIANAPNPAGQSILQRYFEGGVSPLGLLAAALLPTLIIGLVFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJL2</accession>
    <name>A0A139SJL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">AXK12_07000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712748.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07000"/>
    <dbReference type="EnsemblBacteria" id="KXU34768">
        <property type="protein sequence ID" value="KXU34768"/>
        <property type="gene ID" value="AXK12_07000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="8">
        <location>
            <begin position="52"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="408" mass="44541" checksum="0FC63B08BD9213E6" modified="2016-05-11" version="1">MKPSLANLRKKAAALAERIPLGRLHPACAVGAADDALARLSQQKAGGDPARLALALSGGADSVALLLLQWAHYPQSRGDLLALHYNHRLRGEAADRDEAFCRELCGKLGVEIAVGRRPDGVALRSEAAARAARFAFFAEEMERRKTQTLWLGHQQNDVAETLLMRLVRGSGTGGLAAPRPVQRIAASGSFPERIHLRPLLTLSRAEIEAALRECGIPWREDATNTGGEFFRNRIRRDVLPALITASAPHRPAAGERRNSDVAPRATNEGNVSEGRDALAGMALSRELLDEDDAALDAWASAVVKRVIREGCIDLRELNGEVSSRWASTRRAREPAAKEFSLPLPRAVKRRVLYRWLRDHAGAPLLSRQAFEALLVAIESGKSTRQSLGKTGFALIRQRTLKFEPNNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJP0</accession>
    <name>A0A139SJP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_06955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000049">
        <property type="protein sequence ID" value="KXU34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712734.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06955"/>
    <dbReference type="EnsemblBacteria" id="KXU34761">
        <property type="protein sequence ID" value="KXU34761"/>
        <property type="gene ID" value="AXK12_06955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="66" mass="7562" checksum="D0DC70A231FC9E12" modified="2016-05-11" version="1">MRDDYIKAAQKVINDPNLLINVVSHRVKQLKRGNRPLVESLEKLSSEEIALREIIEGKISYELAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJS3</accession>
    <name>A0A139SJS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">AXK12_06845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000048">
        <property type="protein sequence ID" value="KXU34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712696.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06845"/>
    <dbReference type="EnsemblBacteria" id="KXU34801">
        <property type="protein sequence ID" value="KXU34801"/>
        <property type="gene ID" value="AXK12_06845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="120" mass="13213" checksum="E125331BFA6F2D0F" modified="2016-05-11" version="1">MDTILKSKLLQKRRWRIRKKINGTAERPRLSVKFTGKHIYAQAVDDEKGVTLAFLSSLAPDLRQKKLAANVAGAQELGTAFAAKAKEAGISSVVFDRNGARYHGKVKQFAEAAREGGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJV3</accession>
    <name>A0A139SJV3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltA</name>
        <name evidence="9" type="ORF">AXK12_06350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712511.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06350"/>
    <dbReference type="EnsemblBacteria" id="KXU34858">
        <property type="protein sequence ID" value="KXU34858"/>
        <property type="gene ID" value="AXK12_06350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="435" mass="47959" checksum="42E6142DEC478220" modified="2016-05-11" version="1">MTKTPLLHLENKTYELPFIEGTEGEKAVDVRRLRAESGYICFDQGYGNTGSCESQITYIDGDAGILRHRGYPIEQLAEQSEFVETAYLVIYGELPNAAQRRAFGDLLRTHAEVEEPLQRIFEGFPRTAPPMTILASVVAALAAHHPELAANNFEKDLAVFDTAAAMAISKTRTLGAMIYRHRKGLPFVPSKDTTFCENFLHMMFSQKEPGGPDYLAEPEVVKALNLLLLLHADHEQNCSTAAVRMVGSSSANLFASLSAGVSALSGPLHGGANTAVMEMLQQIHDAGDDGSRFIEQAKSGSKSTRLMGFGHAVYRNFDPRAKIIGAACEKVLAKLGINDPLLDIARHLEQAALRDDYFLSRKLYPNVDFYSGIIMRALGIPVSLFTVIFAMGRTTGWIANWYEVASQPKGRIYRPRQVYTGPVKRDYVPMAARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK64</accession>
    <name>A0A139SK64_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712447.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06175"/>
    <dbReference type="EnsemblBacteria" id="KXU34951">
        <property type="protein sequence ID" value="KXU34951"/>
        <property type="gene ID" value="AXK12_06175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="282" mass="31105" checksum="A65D4D2A1D245D2A" modified="2016-05-11" version="1">MKFSQPKADIFTPDGADPATALARTTHLCVLAHQDDIEINAYPAVAECFGRADRHLSGVIVTDGAGSSRSGPYANYSDEEMKAVRAEEQRRAARLGGYGLQIQLAHPSSAVKAPNNEAVRADLRMIFENCRPQVVYLHQPLDKHDTHVATFLRALEAIRSLPRQARPPRVLGVEAWRSLEWLLAEDLVALDASAHDSLKRPLIEVFASQVVGGKRYDDAALGRRRANATFLDAHASDQLSELCWAIDLSPLAHDDTLRVEDFALAKIDRLRAEVASRLTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK66</accession>
    <name>A0A139SK66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">AXK12_06140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712434.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06140"/>
    <dbReference type="EnsemblBacteria" id="KXU34945">
        <property type="protein sequence ID" value="KXU34945"/>
        <property type="gene ID" value="AXK12_06140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="308" mass="33293" checksum="7012CCB35AFA691F" modified="2016-05-11" version="1">MTALPDTAPPKATLGDYLALTKPRLSLMSVLTALIGYVAARPPWIFLEFASLIVGTCLAAAGVAALNQWLEADTDARMRRTATRPIPTGKIPPGSAFVLGALLCTAALAVIFVNINGMAAIFTLLTIASYVGWYTPAKRRSRWSTEIGAIAGAFPPLIGWAAAEAGISPLGWILFGILALWQIPHFMAIAWVYRRDYSAVDFPMLAVRDESGNWTAAWSLINAIALLGVSLLPWWLGLASGYYGMVAALSGLWFCWRAWRFLRPSDDRSASAGAGNARELAARALFITSLLYLPVVLMGLLADRLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK84</accession>
    <name>A0A139SK84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_06280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712484.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06280"/>
    <dbReference type="EnsemblBacteria" id="KXU34971">
        <property type="protein sequence ID" value="KXU34971"/>
        <property type="gene ID" value="AXK12_06280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="275" mass="29272" checksum="10F544EA6248E377" modified="2016-05-11" version="1">MSAFPTTPPTAPTPSTLDEALRLLEAERARSQSDRLEAVARFASMAVHDYNNLLSVINGYCEMLAPELEPQPEIAAQVAEIHKAGKKAVELSRLLMGLSGKQSFEPQTVDLNSLVQEQRSYLTGLVAISRASLHVEAASPEPCRVQTDTEQFKQALHHLVANARDAVSGQAKGEVVLKIELRTGECSNTQAVALSIVDNGTGIDESVHARLFEPFFTTKRTGKGVGLGLFFVDSVVKRSGGTITARNAAPQGAIFEIVLPLVTAGSANPANGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKA4</accession>
    <name>A0A139SKA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5069 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712632.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34920">
        <property type="protein sequence ID" value="KXU34920"/>
        <property type="gene ID" value="AXK12_06735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031849">
        <property type="entry name" value="DUF5069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16798">
        <property type="entry name" value="DUF5069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5069" evidence="1">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="149" mass="16265" checksum="0BD6B95F4AA14F87" modified="2016-05-11" version="1">MAINLSAPDLTQHPPRSMRAKLGGYVHLPRLLDKGRAANADKLGAYQYNSPLDQLFFGFAGIDAEEFKAQLATGKSDSEMLAWIGEKSSRTPFEIKAWSDWAIEAGPGSADSHVWFGGVFKDAAPAREDIRNFADLIDLDDYVSFGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKB9</accession>
    <name>A0A139SKB9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_00150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712352.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00150"/>
    <dbReference type="EnsemblBacteria" id="KXU35018">
        <property type="protein sequence ID" value="KXU35018"/>
        <property type="gene ID" value="AXK12_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="491" mass="53147" checksum="90142DEBAF8DC1BF" modified="2016-05-11" version="1">MSSPAAIPVPAPLLQGEAVPQNASPKMPTLLRHNLRYCSLDGIAAMPIAVLGQPGNVVLASLLSGLFGLSPAHYGLIISLPFWFNFLQVLVTPRLSQQMDARRLCIVTAWLHFSGWALLTAALPFIPRADTPLTLGVFFVGFSIISFAGAVNGVTWNAWMQDVVPQRLRGKYFGMRNQVLQVSMIVFLLSVSGLTALLQGSLGAYMLLFGLALGVRVLSIFAMQRMATPGEATVGVASPGLGAQSRLGWAEQLQVLWADKGLMRFIGFGALMAFFVNLFGPFYPIFMYEELGLSVARANWILLFIPVGAAASFPAWGRLLDRYGNIPVMIVTLGLGQLFSLIWCVIDQTNLWLLYLVAAAAGMFSAGYGVGLFALMLKLMPPSARTLGVALFISLSSLAAAAAPPLGGYLITWAKDYGFDALAIYRMAFAVSPIASIFGILILRRVREENAARVGEVVGAMRNVRTVTALFGLSFLVNQVFYRKVGRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD2</accession>
    <name>A0A139SKD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35028">
        <property type="protein sequence ID" value="KXU35028"/>
        <property type="gene ID" value="AXK12_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="64" mass="6440" checksum="9C4226C9FEA9D04F" modified="2016-05-11" version="1">MGEVGKITSKLPPPNKTACGCAPRVVEKCSSLMSCVAGPAEGGKVGCVLHFVGAIIVRADTALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKG8</accession>
    <name>A0A139SKG8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_06235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000046">
        <property type="protein sequence ID" value="KXU34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712492.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06235"/>
    <dbReference type="EnsemblBacteria" id="KXU34974">
        <property type="protein sequence ID" value="KXU34974"/>
        <property type="gene ID" value="AXK12_06235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="212" mass="22963" checksum="7FBBA8A92E50F8CE" modified="2016-05-11" version="1">MPNLTAPSEVTPNAASGSPLFLVLAGPTASGKSTLCERLVADAALGFARVVTTTTRAPRPGEVDGVHYHFLSPAAFEEKQRAGEFLEWAWVHGDRRYGTLASSVIEPLARGQALVANVDVQGVASFREARAQYPLLAQSLVTVFIEIAPEQLQARIRARGTDDEAEIARRVATAEREMAEAAKFEYRIKSGSRDQDYAALLAIIAQAKSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKH5</accession>
    <name>A0A139SKH5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">AXK12_00160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712356.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00160"/>
    <dbReference type="EnsemblBacteria" id="KXU35020">
        <property type="protein sequence ID" value="KXU35020"/>
        <property type="gene ID" value="AXK12_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="303" mass="33357" checksum="69DE8E86DBCC260B" modified="2016-05-11" version="1">MSRKRIHVITGCTAVGKTELALRWAEAHGAEIVSCDSLLFYRGMDIGTAKPTAEERARVPHHLIDVCEPSEPMDIARYCDRARAVVEQLSARQAAGVPILVTGGSGFYLKAFFAPVVDRVAVPEEIRTAVAALSLDEAVAELRRLNPSEAALGGLDLANPRRVARALERCLATGKTVAELRREFAAQPSLFADYELRLTELVREPDDLARRVRERVAAMLRAGLLDEVHGLLTRGIKENPSAAGAIGYRESIAVLEGRAPLAELEAQIVRNTLALVKKQKTFFRAMLPEHERVDLRQWVDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKJ2</accession>
    <name>A0A139SKJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712424.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00215"/>
    <dbReference type="EnsemblBacteria" id="KXU35055">
        <property type="protein sequence ID" value="KXU35055"/>
        <property type="gene ID" value="AXK12_00215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="148"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="376" mass="40232" checksum="AB1463193243487C" modified="2016-05-11" version="1">MTKYNRSAEPKTPALFAAASRPVFGRVFECGSAGLLRAATYFVLCCGLVVLGDIALKGGRTVFQAQWPFVNVSFLTQAPESLHVFEYAGETHEMGDAQFRAFRANALRGAGRAAEPSSPNISGEQGSAVPAIRSQSYVYAAGGIWPCIVGTVLLVSGAMGIALSLGIGAAIFLSEYAKEGRFLRLVRLCILNLAGVPSIVFGLFGFGLFVNFFGWNVSLLAGWCTLAVMVLPVVITAAEEALKAVPSGLREGSLALGATQWQTIRRAVLPCALPGILTSSILGIARVAGETAPIMFTAAYVVRDKLPWEVERLGDFFFQGVMALPYHIYVVSTKIPQNAYTARVQYGTAFVFLAVVGLLALGSILLRGRLKKTYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKX8</accession>
    <name>A0A139SKX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712218.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A139SKX8"/>
    <dbReference type="STRING" id="1548208.AXK12_05880"/>
    <dbReference type="EnsemblBacteria" id="KXU35228">
        <property type="protein sequence ID" value="KXU35228"/>
        <property type="gene ID" value="AXK12_05880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="242" mass="25998" checksum="02A5B244FB05E985" modified="2016-05-11" version="1">MTKLLSGKIAAVTGAASGIGLATTQALIKAGAQVVLIDKDERALNAACEGHSGSAIPLVADLLNVEQCKQLADNILALVSYVDIFHANAGIYIGGDLVDADLDHIDRMLQLNINVVFKNVRSIIPHMIERKTGDIIVTSSLAGHSAVLHEPVYSPSKWATHSFVQIMRRQLLPHGIRVGSVSPGPVSSALLADWPEENLRKAKENGSLIEPSEIADAVLYMLTRPRNVTIRDMVIIPSSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKY3</accession>
    <name>A0A139SKY3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_05760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712167.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05760"/>
    <dbReference type="EnsemblBacteria" id="KXU35209">
        <property type="protein sequence ID" value="KXU35209"/>
        <property type="gene ID" value="AXK12_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="305" mass="32406" checksum="7CDE54B1B5A97916" modified="2016-05-11" version="1">MLNTFLSILPIFLFIVAGYIGKNYFLLEDGFWKSVDKLVYYVFFPSLLLLDISRANFDNTGTSTAIVATIGGTLMVAALIFAGQHVIKVRNDLFTSISQGGVRYNSYVLIALSQSLFGAEGVALSGIFIAYMIVITNVMSVLVMNHYGNGGEKSFKGTLVAIVKNPLIIAALLGLSINVIGLNITGAIKQFLSYLGSAATPLSLMSVGSGLMLSMQASRTIATIYAVSLKLLIMPICTMVLLKVQGASGVPANIALLYAAVPCAGNAYILARQMGGDSEAMASIITWTTMLSGITITLILGSFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL03</accession>
    <name>A0A139SL03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35248">
        <property type="protein sequence ID" value="KXU35248"/>
        <property type="gene ID" value="AXK12_05990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="281" mass="30565" checksum="0595994839F2BB74" modified="2016-05-11" version="1">MLDVVNVNEADLAAAAEAYHRDGYFIARGLFSPEEIADINAVFHKMHADGGVPGFYEPGKPSYAEVPLANYKEDPLVVWTRVMLPHRFNETARAYMLHPKVRVYLEKFMGGEPVAAQSMYFFKAPGSRGQAMHQDNFYLMVEPSTCMAAWTACDDADPENGGLMVVPNSESNELVCPDVADTTVSLSAQRVPIPKGQRVVPAVMKAGDTLFFNGNVIHGSGPNRSKDRFRRSFICHYAKGDLARISQFFNPLVSMDGHDLTVEGNTGGGPCGGAWEGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL13</accession>
    <name>A0A139SL13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35236">
        <property type="protein sequence ID" value="KXU35236"/>
        <property type="gene ID" value="AXK12_05930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="263" mass="28842" checksum="C342CA348DF5FBC5" modified="2016-05-11" version="1">MKHFKNAGVQVRKSPHLPLTSKKEILPMKTKTPPLFALAAAALLVASPRAAVAGGEGVAAVAGLIGGMIIGSHIGSTHTHTTETVVVERTTGTASEQAAPETTTTTTTVTRNGVPGHWEERPVQTWMPARWITTYDHYGFPVRRYVPGYYQTHVERVWVSGVATVGYGPGIFEPTVVVAPAPIIVAPRPYYYNSGYYGNHYRPHYPVVRPLPARHYTPHYPVRPTAPRHYAPNYRSNHAPSYKANHVRGRVNSGSGGLRPKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL15</accession>
    <name>A0A139SL15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_05610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712118.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35184">
        <property type="protein sequence ID" value="KXU35184"/>
        <property type="gene ID" value="AXK12_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="156" mass="17318" checksum="34290EF995F2E05E" modified="2016-05-11" version="1">MKTIEQIRLKNLLEIRSKFRFIRDLAKAVKKSDQQVSQWLGKSSCARSIGSTSAREVEEIMGLPQGWLDNDHEPRERLSEALVSHVMAEMLPETPQTAPATFAEKLRDAVFNPSGHYVAPPELDAYRQSSEEVRAVIMAASRAAAAAEAVVSRKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL51</accession>
    <name>A0A139SL51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_05435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712045.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05435"/>
    <dbReference type="EnsemblBacteria" id="KXU35292">
        <property type="protein sequence ID" value="KXU35292"/>
        <property type="gene ID" value="AXK12_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02231">
        <property type="entry name" value="TIGR02231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299322" evidence="2">
        <location>
            <begin position="23"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4140" evidence="4">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="228"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="560" mass="60632" checksum="6D304CC9534A4DD8" modified="2016-05-11" version="1">MIKHLLLVPTLLLAATGLPALAAAAATQLNTTISAVTVYNDRAIVTRTARAEVQAGLNELHIEGLPASLIDDSLQAAATGTADATLLDITARQTFVATTPDPRRAAIEDALTSLREEERSLNDRAALLKSHRDLLDRLQNSAVTITGGERAERPKLDEVEATLAYGQAEIAKLNTQLQALDRELAQLQAQITAHQNQLDELPALPSRRSVKTATLRIQAAQPGDLDIELRYTTPQASWRPAYDAHVSTTESRVQLGYFAQVRQTTGEDWENVALTLSTARPSLGGHAPELSPWHLDLVPDAANEENAPLVRLQNRKALGFGAAPAPRLAAAQSSGERMTFDLVAADYAEAALDPSSTVATFTIATPATLHSDNSPQKIPVTTLDLDAEITYRATPKLRSIAYRDAHISNTSDFPLLPGQMNVFVDRTFIATSRLTHTSPGEKFNLALGADEALAITHKQVRRFTEQVGLMTKSTRTSYEYLTTVTNNKPGPLRLILADQVPVSRNDKITVKIQAPAAREARPDAEGKLEWTLDLAPGETREVPLNFTVEHAVGLAIDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL72</accession>
    <name>A0A139SL72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712050.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05450"/>
    <dbReference type="EnsemblBacteria" id="KXU35295">
        <property type="protein sequence ID" value="KXU35295"/>
        <property type="gene ID" value="AXK12_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="266"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="341" mass="36726" checksum="A7BAEE674D724450" modified="2016-05-11" version="1">MLTGPTWSEKLRSEIAKTVIGQDAVVERLLVALLAGGHVLLEGMPGLAKTLLVKSLGTALGVQFERIQFTPDLLPSDVVGTMIFQPKTGEFSAHHGPIFANLVLADEINRAPAKVQSALLEAMQERQVTIGGSTHPLPRPFFVMATQNPVEQEGTYPLPEAQTDRFLLKLLVDYPSADEEAAMMERWGQVARQPELCAVSSGEELLALRPQVDAVHVSPAVRSYILSLVRATRALAGHGDGDVNEAAATGRAANERPANKEGPRPLEFGASPRASLALYQAGKALACLRGQDYLTPALVQEIAPEVLRHRIGLTYEAEAEDITADTLIAQVIERSPVPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL74</accession>
    <name>A0A139SL74_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="9" type="ORF">AXK12_05525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712084.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05525"/>
    <dbReference type="EnsemblBacteria" id="KXU35308">
        <property type="protein sequence ID" value="KXU35308"/>
        <property type="gene ID" value="AXK12_05525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="396" mass="42861" checksum="6477513784518B26" modified="2016-05-11" version="1">MAKGTFERTKPHVNVGTIGHVDHGKTTTTTAILAVQARKGLAEVKTYADIAKGGTVRDASKIVTISVAHVEYETANRHYAHVDCPGHADFVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPKLVVFLNKVDLIDDPELLELVEMEIRELLSKYQFDGDNAVIVRGSATAALEGTPEGEAAISALMDAIDKEIPEPAREMDKPFLMSVEDVFSITGRGTVATGRIERGLVKVNDNVEIVGLRDTQTTVVTGIEMFRKLLESGQAGDNVGILLRGIDKDAIERGQVLAAPKSITPHKKAKAEIYVLSKDEGGRHTPFFNGYRPQFYFRTTDVTGVVNLPEGVEMVMPGDNIAVEIELISPIAMEKTQKFAIREGGRTIGAGRITEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL78</accession>
    <name>A0A139SL78_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_05545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712089.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05545"/>
    <dbReference type="EnsemblBacteria" id="KXU35311">
        <property type="protein sequence ID" value="KXU35311"/>
        <property type="gene ID" value="AXK12_05545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="74"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="247" mass="26296" checksum="9C6D634E38CEDB2A" modified="2016-05-11" version="1">MAFTDFSLFARGGPMMWVLLVLGFLCLVLFMERVFYLHRGQIKAAEFLGGIKNILAKRRIVEALTVCEETPGPVAAVVKAALLHAEDDADRLRFEVQEAAVIELPGLERRLGSIAAIAQVAPLVGLLGTVLGMATTFYAFERDYATASALSEGMWQALLCSVGGLLLAIPAHLAQHFLAGRVRAIVRDIEWAGNEIMRYLLTDYQRSGASAASTTEGSVSEKSGQAGVPSNAAEIAQSASLGEGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL79</accession>
    <name>A0A139SL79_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">AXK12_05505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068630741.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05505"/>
    <dbReference type="EnsemblBacteria" id="KXU35305">
        <property type="protein sequence ID" value="KXU35305"/>
        <property type="gene ID" value="AXK12_05505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="141" mass="14789" checksum="EE885614BD6B9B7A" modified="2016-05-11" version="1">MAKKIQGYIRLQLPAGAANPAPPVGPALGAQGVNIMAFCKEFNAKTKDQNGMILPVVITVYADKSFTFILKSPPAAVLLKKAANIASGSAAPNKDKVGKVTRAQLAEIYKIKAKDLNANDEEAGIKIIAGTARNMGLEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL84</accession>
    <name>A0A139SL84_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">AXK12_05970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712253.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05970"/>
    <dbReference type="EnsemblBacteria" id="KXU35244">
        <property type="protein sequence ID" value="KXU35244"/>
        <property type="gene ID" value="AXK12_05970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="206" mass="22667" checksum="626A6A33B9B3FCA6" modified="2016-05-11" version="1">MLLDLVYYNSPLLREKGAPITVFDSALRDFSAAMIETMHQSGGIGLAAQQVGRAIQLCVVDVRKSKIDFDWELDGASPPLDLFMPMVIANPQISFAPQNEIMIYEEGCLSFPKVGAKPIRGDVERPDKITVSYQDEHGVAHTLTTTGILSRCIQHEADHLKGTLFIDRLDRRTRTKIDQSLKQLAASTDEAKTAATIAEAAKPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL86</accession>
    <name>A0A139SL86_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur acceptor protein CsdL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712098.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05565"/>
    <dbReference type="EnsemblBacteria" id="KXU35315">
        <property type="protein sequence ID" value="KXU35315"/>
        <property type="gene ID" value="AXK12_05565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="14"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="273" mass="29024" checksum="F98FE93CDFCC51F0" modified="2016-05-11" version="1">MTDDYLQRFGGLTRLYGRAGLLRLHAAHVCVVGLGGVGSWVVEALARSGVGALTLVDLDDLCITNVNRQLPAMDGTIGRPKAEVIAERVSRINPACRVRVLTEFFTSQNAERILAEGFDCVVDAIDNVSNKALLLAECVTRGLPAVTVGGAGGRSEFNAIRTGDLGEAWGDELLRLVRRKLRRAHGFEAGTQKGRMQFGVRCVWSSEPRIFPWADGTCRTEPAPEAGREGAGKLDCESGLGAAAFVTGAFGLAAAGEALRCVISPRLETAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLD9</accession>
    <name>A0A139SLD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">AXK12_05500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712080.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05500"/>
    <dbReference type="EnsemblBacteria" id="KXU35304">
        <property type="protein sequence ID" value="KXU35304"/>
        <property type="gene ID" value="AXK12_05500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="231" mass="24512" checksum="567DDB020C74A49A" modified="2016-05-11" version="1">MDKKSKRYVSGTQVADLTKDYSLQEAVEILAKFPKTKFDETVELAFRLGVDPTAGEQMVRGTTPLPNGSGKTVRVAVFTDDAEAALAAGADHAGLQDLMAKVSEGWLDFDVAIATTEAMKQVRTLARVLGPKGLMPNPKSGTVTDDIAGGIKAVKAGRVEFKMDKSGNIALGVGKRSFTNEQILENAQTVIEAIGKARPATFKGSGYIKSIALAATMSPGIRLASSEFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLL2</accession>
    <name>A0A139SLL2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711968.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35380">
        <property type="protein sequence ID" value="KXU35380"/>
        <property type="gene ID" value="AXK12_05260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299353" evidence="1">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="164" mass="18393" checksum="2860CA0154B40290" modified="2016-05-11" version="1">MRRITTLLASLLLALSAPATESTVSLVRIWPSWRSADSFLRISEYFGGSEARSAQTILRSQTSERAGFYFLTRIKNSASPLTDAHFELQVIRPDSPHAVTYTFPATIPTGSHVYLLGLTGSDWLGFDGKAAEDTHPVSWRLRLLDSQARELLHRESYLWANPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLT0</accession>
    <name>A0A139SLT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_05135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000039">
        <property type="protein sequence ID" value="KXU35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35506">
        <property type="protein sequence ID" value="KXU35506"/>
        <property type="gene ID" value="AXK12_05135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="95" mass="10458" checksum="185CB4F338799BD7" modified="2016-05-11" version="1">MEVRKIAIDNSTLSVLAVGVALFVLAFGAFTHLSGRIDSLDAKFDARIDRLDAKIEKVSSELNAKIDRVDAKIDAVNARLDRLFELIASQGRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM15</accession>
    <name>A0A139SM15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphoribosylformylglycinamidine synthase</fullName>
            <shortName evidence="10">FGAM synthase</shortName>
            <shortName evidence="10">FGAMS</shortName>
            <ecNumber evidence="10">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Formylglycinamide ribonucleotide amidotransferase</fullName>
            <shortName evidence="10">FGAR amidotransferase</shortName>
            <shortName evidence="10">FGAR-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purL</name>
        <name evidence="15" type="ORF">AXK12_04930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="10"/>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711849.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04930"/>
    <dbReference type="EnsemblBacteria" id="KXU35597">
        <property type="protein sequence ID" value="KXU35597"/>
        <property type="gene ID" value="AXK12_04930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_N" evidence="14">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT_linker" evidence="13">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="12">
        <location>
            <begin position="472"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="12">
        <location>
            <begin position="879"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="1182"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="1307"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="1309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1342" mass="144735" checksum="32AD1F10F7B840F4" modified="2016-05-11" version="1">MLTLRGSAALSPFRLEKLLKTLSDEHRLPLRAIEAHFIHLCNTSGDLTPQEHAILERLLSYGPSREAKSSRGGQSGLQLVVSPRPGTISPWSSKATDIARLCGLDKICRIERVVEYTLILDNAALQPPLHVLNTAQLNALRAALIDPMTQAAFDTLDECAALFRHEAPRPLRTIPLLAKGRSALETANRELGLALAPDEIDYLAEAFSRLGRDPADVELMMFAQANSEHCRHKIFNATWEIDGQPQAHSLFAMIRNTHQLHSDGILSAYKDNAAVITGTHGGRFFTDPLTGDYDAHPEPIHLLCKVETHNHPTAISPYPGAATGSGGEIRDEGATGRGSRPKAGLVGFTVSNLKLPDAPQPWEHDYGKPARIASALDIMIDAPLGGAAFNNEFGRPAINGYFRTFEAAVPAREKTKPGDAPRSKEDNAPTTATRPTSEDCAPELRGYHKPIMLAGGLGNIRAEHVEKGEIAPGDHLIVLGGPCMLIGLGGGAASSVASGSGTESLDFASVQRDNAEMQRRCQEVIDRCWALGAENPISFIHDVGAGGMANALPELVNDAGRGGRFDLRKLPNDEPGMSPLEIWCNESQERYVLSVPAARLATFEQICHRERAPFAIVGEATERKDLVVEDPHFANRPIDLPLDVLLGKPPRMHRRETTLARPQHPLDLGGATLAEAVQRVLSHPTVADKSFLITIGDRSVGGLIVRDQMVGPWQVPVADCGVTAAAFDTNTGEAMAMGERTPVAINNAAASARLAVGEALTNLAAAQVGPLGKVNLSANWMAAPDQPGDAAELYAAVRAVGLELCPALGITIPVGKDSLSMSTVWADETSGAQKRVTAPVSLIVSAFAAVEDVRLSLTPQLVRDADTTLLLIDLGRGQNRLGGSILAQTFSQIGEATPDVDSPRDLKAFWDAIQVLSRDRKLLAYHDRSDGGLFTTLVEMAFAGHCGVEIVLPKDDAATTPRQIKGAATLFSEELGAVIQVRNANLAQVHAILNTHGLDDCTHEIGRPTPDAHQVKVAAQNGDLLWEEDLFALRALWSDTTRRIAQKRDNPDCAEQDYQLKLDRRDPGITPKVTFTLSPAPRRDQRPTVAILREQGVNGQIEMAAAFTRAGFRAVDVHMSDILAGRVTLRDFAGLAACGGFSYGDVLGAGEGWAKTILFNERARAEFADFFAREDSFSLGVCNGCQMLSNLHELIPGADGWPRFVQNKSERYESRLVSVKIEDSPSVLLRGMAGSVLPVVVAHGEGFCEFPSTDAAAAFNATPLAAARFVDNHHAPTENYPLNPNGSPEGLTALTTRDGRVTIMMPHPERVFRTCSLSWAPANWPEDSPWMQLFHNAYAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMA0</accession>
    <name>A0A139SMA0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MurNAc-LAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711761.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04710"/>
    <dbReference type="EnsemblBacteria" id="KXU35671">
        <property type="protein sequence ID" value="KXU35671"/>
        <property type="gene ID" value="AXK12_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="218"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="374" mass="40219" checksum="EB256DE1048E20D0" modified="2016-05-11" version="1">MAKPQRWIFALGLVGLALSRLTSPSLLAVETLKRERVTGAASTAATVGVDYVRAADFAAKFGLKPEPSPDGKKLTLKSPWTEIALEAGSREIAHNGLRIFLGDGVRQQGGHFLISKLDIDKVLVPLLLPGYGLGTQATGAASYGSPPNLKTIVIDPGHGGRDPGKVNAKLGVNEKTMTLDTAQRLARLLEARGYKVLLTRLGDSSLDTDKNTDLRARAHFARAAAADLFISLHYNAVDGSPATLARVRGAEVYTLTPQHQHSSGDPERQDKNGAAVALPGNAYDHWNMIIGHEVHRALVKTVAVADRGLKRARFAVLREVTCPAILVEAGFLSNDEEAHKIMSPEYRQQLAEAIASGVVMYDAALEAVRRRAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB4</accession>
    <name>A0A139SMB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein AXK12_04765</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_04765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711779.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04765"/>
    <dbReference type="EnsemblBacteria" id="KXU35681">
        <property type="protein sequence ID" value="KXU35681"/>
        <property type="gene ID" value="AXK12_04765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="251" mass="26945" checksum="11A72D8CFE9EE61E" modified="2016-05-11" version="1">MAGHNKWSKVKRIKAVTDARKGKVFSRLSRDITLAAKAGGGDPDSNARLRTLLLKARDANMPADNVDRAIKKGTGELPGVVFEELAYEGYGPGGVAFIVKVTTDNKTRSAQEVRSAFSKLGGNLAQSGSVAFQFLHAGQFLITKDQAASEDQLMEVALEAGADDVIVSDEGYEVRCDLHDFDKVLHALETAGIKTESAEISYIPTSTIAVTDAQVAKTLLKLHDVLEDLDDVQAVFSNEELDDAVSNAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMB8</accession>
    <name>A0A139SMB8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yidC</name>
        <name evidence="17" type="ORF">AXK12_04770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711781.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04770"/>
    <dbReference type="EnsemblBacteria" id="KXU35682">
        <property type="protein sequence ID" value="KXU35682"/>
        <property type="gene ID" value="AXK12_04770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299274" description="Membrane protein insertase YidC" evidence="15">
        <location>
            <begin position="29"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="16">
        <location>
            <begin position="277"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXU35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="624" mass="67721" checksum="A097957C9405BC61" modified="2016-05-11" version="1">MDKKNTVVGVALLMAAFAAMYFSAQRQAAAPPPLPAQHAPATAGQQPAGVAAPSGTIATPGGAPVAPTLVATAGPATAEIKALAPSATGETTALLANAFIEVRLSNRSAAIEEVALRRFPQELGSSHHFVFNQVRTGPMLGINTLPGVGALGAAFEVVSQNPREVIYRARLDSGRLELTRRYYLPDGSEPGTDPYQLQHETTLRNLSGDTLALPRLALSLGTVRATGEDVYGQQLTSGYSDGKKQHFIEHTRLKGGGFLSLFGIGSREPTPELPTHATVRWASLGNRFFASILTPAEPAVGIVTRRVPIAENPDIPHATSYGLGAEALFDLRPLAPQESSTLAMDFYIGPKAYPRLSNSDNFKANQDKVMNYGMFRFFSQTLLTMMNWVHGWLSPLSPKWAWGWAVVLTTLTLKIVFLPLTLAASRSAKRMQKIQPEMQALREKFKDNPQKMQQATMELFKRNKVNPAGGCLPILVTMPFFIGFFVMLRTASELRFESFLWASDLSAPDTVARIFGLPINIMPILMGATMIIQMRLTPTPSADNMQAKLLKFMPWMFTLFCYNFSCALALYSTVNGIFTIGQQLVINRMKTDGPAPTATDLGGASSGKRGKPLKNVTPPARKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMM1</accession>
    <name>A0A139SMM1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fcl</name>
        <name evidence="4" type="ORF">AXK12_00090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711738.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00090"/>
    <dbReference type="EnsemblBacteria" id="KXU35848">
        <property type="protein sequence ID" value="KXU35848"/>
        <property type="gene ID" value="AXK12_00090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="311" mass="33903" checksum="8CD69CFC93CFE822" modified="2016-05-11" version="1">MKLFIAGHQGMVGSALVRRFAREPGVALILRSRAQLDLCDQAAVNAFYEAERPTAAIIAAGKVGGIHANATYPADFIYTNLAIAVNCIHGAWRAGVRRLLFLGSSCIYPKHAPQPMPEDCLLTSELEPTNEAYALAKITGLKLCQHYRAQHGVLYHSAMPTNLYGPGDNYHAHNSHVLPALIRRFHEAKEAGAPSVSAWGTGSPRREFLHADDLADACAFLLAQDSPPDWLNVGTGTDVTIRELTERVAATVGYEGQIKWDTTKPDGTPRKLLDVSRLSALGWRARTSLEDGLRQTYASYLAEKADGTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMW2</accession>
    <name>A0A139SMW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711744.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00105"/>
    <dbReference type="EnsemblBacteria" id="KXU35851">
        <property type="protein sequence ID" value="KXU35851"/>
        <property type="gene ID" value="AXK12_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="8">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="383" mass="40907" checksum="CA3388B497A4894D" modified="2016-05-11" version="1">MRAQLLARFQATFGRAPTLIARAPGRIEFIGNHTDYNGGTVLGAAIDRSLWVGLAPRDDARRRFGADYSGHDLVELPAHPLAPQHGKASWVNYPLGILAAFPDFGLCAPAGFDLYVVSNLPSGAGLSSSAALELASALVFAAATNQQIAREQLVAIGRHAENHFVGVPCGILDQGVCAFGQKDHLVFIDCRGPQFSTVPLLPDTRFWIFNTHTKHALVDGLYAERNRECMQAAQRLGVSQLAALTPEAFASHPEKNALPPAVARRAQHVVEEIARVGAVHRALHAGDLHNTGALLTASHRSSQHLFENSTPELDFLVDTLTPTPGVYGARLTGGGFGGAVMALTHTQFSQAHAEQIARAYSKKFGGEVQILETRTADGANLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN37</accession>
    <name>A0A139SN37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">DNA ligase</fullName>
            <ecNumber evidence="9 10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="12" type="ORF">AXK12_04595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9 10"/>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711690.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04595"/>
    <dbReference type="EnsemblBacteria" id="KXU35965">
        <property type="protein sequence ID" value="KXU35965"/>
        <property type="gene ID" value="AXK12_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="628"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXU35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="710" mass="76284" checksum="21B9A5BC66B8188A" modified="2016-05-11" version="1">MTAPSEASAPERIATLRAELARHDALYYRAAQPEISDADYDTLKRELADLETQFPLFAQADSPTQRVGDDRTSGFATHRHRQPMQSLDNTYSPDELREFDARLTKLVGGEIGGGSMAPAGENKTESAGPLLDYVVEPKIDGVAVSLTYERGRLVRAVTRGNGVEGDDITENALTITTLPRELARGDALLAELGKAPLPELIEVRGEIFMTHAEFERINAERAAAGDSLYANPRNLCAGTIKQKDAREVARRRLEIALYAVGHCEPASALPATQHAVQERLRAWGLPGVEKFWRARGADEVWRAIGELDAIRATFAYATDGAVVKLDSLALQREVGATAKAPRWAIAYKFAAERAETLLTDITCQVGRTGVVTPVAELRPVHLAGTTVSRATLHNFEEIARKDIRIGDWVFVEKAGEIIPIVVGVNLARRMSGVYEPPTSCPECGTPLVRIEGEVALRCPNYDCPAQVRARVEHYASKACVDIDGLGEAMVATLVAKGWVRDIADIYRLRREDLLTLGKKVEKSTDALLAAIETSKRAELWRVIHGLGIMHVGAAVAKDLARHFGSLEALAAATLEDFLGPKKESLIDGIGETMARAIVGHFARAEARALLSALGELGVAPTPPTKATSGVGVFSGKTFVLTGTLPSMSRGEATAKIEAAGGTVSSSVSKKTSYLLAGEGGGSKLEKAQKLSVPVIGETEFMQFLASPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN75</accession>
    <name>A0A139SN75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04175"/>
    <dbReference type="EnsemblBacteria" id="KXU36028">
        <property type="protein sequence ID" value="KXU36028"/>
        <property type="gene ID" value="AXK12_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="146"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="309" mass="34206" checksum="5D780B5BEAFAE6C3" modified="2016-05-11" version="1">MRAAARALGYKSNPLLGEVMRFVRRRAPDRLLGTLAHLVEPEFWEAGSKNRLGRYGPAVKAHALRYNFGVAPFPLGVPDFEPERLAKILLARGIEGVVLEVFPGKAFVESFPWGQFSSVLVGHALRSPGLDCVVSDHSRGVLLAGQKLLERGYRRIGLALEERHVADTNGAWVDGFHLLQQRHPHLGDIPPLIEAEMGAAAFIAWLRKHRIDAVMTISIMHRCQNPMLRWLKEAGVACPGEVAVATLDRSFVPLPWAGLDQSSDEISAAGVDLCMTKLRLGERGIPAIPRTILLHAYWCEGETARRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN92</accession>
    <name>A0A139SN92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711568.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04290"/>
    <dbReference type="EnsemblBacteria" id="KXU36048">
        <property type="protein sequence ID" value="KXU36048"/>
        <property type="gene ID" value="AXK12_04290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="249" mass="27273" checksum="3174C8E29250F3D5" modified="2016-05-11" version="1">MPSPAIETLLILQARDTRRRDLEAQIAATPAEVAAVEAQIAAERAAIDRARDGLRQLESDKKLLETEIGSAEAKLAKYRTQQLAVKKNDEYQALTREIEAMEASIGALEERELELLYAIDAAKERFDAAEATLQQNISGHQARIATLREREQSLRVELIDAQSEIAAARAPVADPLLRLYDRIAARQWPVIVPLQNGICGGSHLRVSSDVDSAARAASRMTAPADDPAALEQLVLSDQSGQILYWVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SND0</accession>
    <name>A0A139SND0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_04100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04100"/>
    <dbReference type="EnsemblBacteria" id="KXU36098">
        <property type="protein sequence ID" value="KXU36098"/>
        <property type="gene ID" value="AXK12_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="221" mass="25612" checksum="29C9909BAAFE70AC" modified="2016-05-11" version="1">MTQGTLENYVGQGGVQRMSAKAQEVALDRLLVDRFKNGDQSAFDEIVSRYWTRIYAMVHQLLRNTQDAEEVTQDAFIRAHRGLPQFRGESAFSTWLYQIATNVARNRYWYWWRRKRDKNLSFDHPLSPEGSMTLADVLPSQTESPDDIAVTHEFVERIGEAMEKLGRKHREILVLRNVKNLSYEEIASVLQISVGTVKSRIARAREHLRSKLGEDFSVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNE6</accession>
    <name>A0A139SNE6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_04565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711664.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04565"/>
    <dbReference type="EnsemblBacteria" id="KXU36095">
        <property type="protein sequence ID" value="KXU36095"/>
        <property type="gene ID" value="AXK12_04565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="306" mass="34243" checksum="A4FC44D6F7EB5ECB" modified="2016-05-11" version="1">MRVLVTGGAGFLGSHLCDRLLAEGHEVICLDNLFTGRKANIAHLLGEPRFEFVRHDVIDPFKFEVDQIYNLACPASPPHYQYNPIKTTKTSVMGAINCLGLAKRVKARVFQASTSEVYGDPAVHPQPESYWGHVNPIGRRSCYDEGKRVAETLFFDYHRENGVDIRIVRIFNTYGPRMHPNDGRVVSNFIVQALRGEDLTVYGDGSQTRSFCYVDDLIEGFVRLMGSETVGPVNIGNPGEFTMLQLAELVLRLVGGASKIVHLPLPADDPRQRRPDIALAKRALGWEPTIPLEEGLKRTIHYFRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNI6</accession>
    <name>A0A139SNI6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">AXK12_04130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711510.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04130"/>
    <dbReference type="EnsemblBacteria" id="KXU36021">
        <property type="protein sequence ID" value="KXU36021"/>
        <property type="gene ID" value="AXK12_04130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="260" mass="27290" checksum="B06FC28701D21F6E" modified="2016-05-11" version="1">MLSRRIIPCFDVHNGQVTRGVQFGKAEAGELTNVGDPIAMAQRYDAQGADELIFLDITASSEGRSIMHDLVRATAEKCFMPLTVGGGLRNTDDIRAMLNSGADKVSLNTAAITEPEFIRAAASKFGSQCVVVAIDAKRAPDGGDSWQVYTHGGRKTTGLDAIEWARRAVALGAGEILLNSIDRDGTKAGFDIALTRAVSDAVPVPVIASGGAGSLDDLGDAFIDGHASAVVVASLFHFGTYTVQQAKDALHARGVPVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNK5</accession>
    <name>A0A139SNK5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711554.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36041">
        <property type="protein sequence ID" value="KXU36041"/>
        <property type="gene ID" value="AXK12_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="293" mass="31087" checksum="2CE733C11FF02FDA" modified="2016-05-11" version="1">MTENKNAGAALLIPGLFVLLWSTGFIVGRLIVDSASPNIFLAIRFFLSFLLFAVIAMVLRRKFPPVTEWHKHALAGVFINGIYLGGSYWAISQGFPAALMALLGALQPAFTMVIGVAFMRENVKPIQTAGILVGLAGVAMVLFPTIGLQGTQSYTFVVPIIALVSVLSITWGTIMQKMSIAKSELLPSLAIQNASATLTAIALALLLGESRLSLNAQFLVALSWAVLILSGLGTYLLVLLVRGGSATKTTSLMLLAPPLAALEAWLLFGDKLTALQILGFGFALLGVGLCRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNL6</accession>
    <name>A0A139SNL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_04450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36074">
        <property type="protein sequence ID" value="KXU36074"/>
        <property type="gene ID" value="AXK12_04450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="89" mass="9724" checksum="FF85CE9AD844ECD2" modified="2016-05-11" version="1">MAALLSLSVHCAWGGSVSLHPFTERLAAVHSHGNQAFGRKDPKLGGGSLLVIFPTSPKRVITLLPLLLLSLSQRDKGRDFQIWDFAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNM6</accession>
    <name>A0A139SNM6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_04000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000030">
        <property type="protein sequence ID" value="KXU36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04000"/>
    <dbReference type="EnsemblBacteria" id="KXU36185">
        <property type="protein sequence ID" value="KXU36185"/>
        <property type="gene ID" value="AXK12_04000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="31"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="736" mass="79017" checksum="16FC9B6B4CEC76E1" modified="2016-05-11" version="1">MTTLPEHLSSSSAVSTEAASAAAVGGGNRPSPTYAIVGNPNCGKSTLFNALTGLRQKIGNYPGVTVEKKVGTAWSQHGQPITLIDLPGSYSLAARSPDEAVTRDVLFGRRAETAAPDRILCIVDATNLERNLYLVHQVLDLGRPVILVLNMMDVARASGLAIDASHLEHELGIPVIPCEAVNGKGIVELRMAMSRASLPLPRHAWDVPAEIAPAVAELQAALMEGEGKPALLARAEALLLLTAAGSAAAAREASDVATFAPESRAATVLSHWQSHWRKEGVDWAASLVAARYDAISALCERVVAQRKPVSAADSASAAAHASRSDRIDAVVTHPLWGWLVLGGLMTLIFFSIFTFAEYPMDWIDGSVASFADWVKEALPEGDLRDLITDGAIAGVGGVVVFLPQILILFFFIGLLESTGYMAREAFIMDRLMSRVGLNGKSFIPMLSSYACAIPGIMAARTIENHKDRLVTILVAPLMSCSARLPVYLLMIAALLPGDTVPVASKVGLMLLMYALGTGGAFGFAWLFKKTLLKGEPPLMIMELPPYRMPALRAVARQMLDRAGLFLKRAGTIILSISIVLWFLATYPRAPEGADESGQLAQSFAGQAGHLIEPAIEPLGFDWQVGIGLITSFAAREVFVSTMGVVFNVDDPEEDTTPLREALAAATWPDGRPLFTPLVCLNLMIFYVFAMQCVATVAVVRRETNSWRWPLFQIGYMTGTAWLACFVVYQVGTALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNN8</accession>
    <name>A0A139SNN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711407.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03825"/>
    <dbReference type="EnsemblBacteria" id="KXU36197">
        <property type="protein sequence ID" value="KXU36197"/>
        <property type="gene ID" value="AXK12_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="290"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="506" mass="57869" checksum="B080DA8B0C7AE180" modified="2016-05-11" version="1">MKVKISVHRDFTISPIDERLYSAFIEHMGRAIYGGIYDPGHPQADEQGFRKDVLKFVQDLNIPAIRYPGGNFVSAYRWEDGVGPRETRPVRLDLAWRCTETNQIGINEFADWAKLAGIDMMLAVNLGTRGLDDARNFLEYVNFPSGTALSDLRRSHGKTEPHNVKLWCLGNEMDGPWQTGHKVAVEYGRLANETAKAFKSFDPSIKTIVCGSSNDEMPTYPEWEREVLEESYENVDYISLHKYFENYERNTLNFFGKIEETGRYIQAISGTIDYIKAKKRAKNDVFICFDEWNVWYHQREKDNRRITEWDWPEAPALLEETYNFEDALFVAGLLNEFIRRSDRVKIACIAQLVNVIAPIRAEKEGPAWRQSIYHPYRLVALYGRGEALRTAVDAPTYNCAAADQVSYLDVASVYNREKNTLTFFIINRHLSETAELEINLTGFPEPCLSEHLAMEGYDLQATNSAQNPDHIRPKPGENVVVDESGSVRGILAPLSYHVLRLSLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNP2</accession>
    <name>A0A139SNP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_04540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Slam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36090">
        <property type="protein sequence ID" value="KXU36090"/>
        <property type="gene ID" value="AXK12_04540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007655">
        <property type="entry name" value="Slam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04575">
        <property type="entry name" value="SlipAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="446" mass="50568" checksum="8A2B158A0C1BE537" modified="2016-05-11" version="1">MTNTAPVETDPEVEEAVQDNALRQLSGQELRDHPRLMAQVIEQLIKQRQWALLPAMLADYEAHQEADPHLVLYAKGALYRQQKNYPLATGAFQALLDLKPELTYVRLDLAMMQVEDKRYGDAIKTLAQLVQHAQTPPPIKQLAQNQLAQLQKLYAVEFTVSGNFTRNDNVNQASAERTIEFAGLEFVKNPESLPKTGHGFMYGLGVRKMLPLAGNHGLSAGLRYSGIHYWDQQDYSESTLRLNPAYHYQTHNQWFRAGPVYEKNWLGGSQYGSRVGAQAEWGRQILPKHYLIPHAEYTHKRYDSPALNRYEGDSYRAGLMWVHQLKPGTAISAGGSYQQDVLNEKAESSKTLALRLGGSYRTKGGWSTQVSLHVGERNFDAMHPLFGMTRRDKELIGSVGIWHRKLRVMKITPKLVYRFSDIRSNIPALYSRQSGGWMVEVADVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNS0</accession>
    <name>A0A139SNS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livG</name>
        <name evidence="5" type="ORF">AXK12_03905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000029">
        <property type="protein sequence ID" value="KXU36206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711423.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03905"/>
    <dbReference type="EnsemblBacteria" id="KXU36206">
        <property type="protein sequence ID" value="KXU36206"/>
        <property type="gene ID" value="AXK12_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU36206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="262" mass="28338" checksum="02B3672778382092" modified="2016-05-11" version="1">MTPLLEIANATIRFGGLSAVSAIDLAIGSGELVGLIGPNGAGKTTAFNLITGVYPPSEGRVCFGGRDLTGLPPYARARLGIARTFQNIRLFGSLSVFDNVRAACNLHRATSPLHALWRGKAFRDDEAAIATQVDALLEIFNLGRYRDTPAAALPYGEQRRLEIVRCLATRPKLLLLDEPAAGMNPAEKTELVALIQQIQRQFHLSILLVEHSMRVVMGVCQRIAVLDHGVKIAEGSPAEIQHNPAVIEAYLGEDHSENLAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU4</accession>
    <name>A0A139SNU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000031">
        <property type="protein sequence ID" value="KXU36164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04030"/>
    <dbReference type="EnsemblBacteria" id="KXU36164">
        <property type="protein sequence ID" value="KXU36164"/>
        <property type="gene ID" value="AXK12_04030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="283" mass="31465" checksum="772C0982228ADEAD" modified="2016-05-11" version="1" fragment="single">MLPELLRRLTVLFDGQVNHERWTAILVDDGSRDDSVAQIEAKCASDRRFRLIELSRNFGFQAALLAGLEQAKASGFDAVVTLDADLQDPPELIPQLVQSWQQEGSNVVLARRRSRRDRGVRALCFKLFHAVFGRVVDIKVDQNTGTFGLLDRKALSAFSRLPESHRFFPGLRAWLGFKRSEVFYDRQERAAGVPTQSFIKLLRYGFDAVFSFSRLPLRLVLVAGAVMAGASFIIGAAFALRRLLGFEIAPTGFTTLATVILLLGGIQLMGLGIIGEYLGRTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP18</accession>
    <name>A0A139SP18_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_03730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711361.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03730"/>
    <dbReference type="EnsemblBacteria" id="KXU36254">
        <property type="protein sequence ID" value="KXU36254"/>
        <property type="gene ID" value="AXK12_03730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="157" mass="16623" checksum="511886EBCDD12AD7" modified="2016-05-11" version="1">MKTILAPIDFSNASNAVIKVALALARAHSARLSLLHVVQPPVLISEYGAIMTNIQEIVAISERTSAKELAKRERSLKRSAGVPVEALQTTGAPVASIIEQAKQTKADYIVVGSHGHSALYDLFAGSTASGLIRRAPCPVVVVPPPATPKKKKASRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP52</accession>
    <name>A0A139SP52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">AXK12_03580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711318.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03580"/>
    <dbReference type="EnsemblBacteria" id="KXU36231">
        <property type="protein sequence ID" value="KXU36231"/>
        <property type="gene ID" value="AXK12_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="254" mass="27960" checksum="393488B8EEAE7DC6" modified="2016-05-11" version="1">MSLLEIRDLHIAIGEKPIVKGLSLTLRGGEVHAIMGPNGAGKSTLSKAIAGHPDYTVTGGDILLDGRSLLDMEPDERARAGIFLAFQYPSEIPGVSLANFLRAAVQARIPEGEELDAVAYYKRLYEKMDHLKIDRKFTSRAINEGFSGGEKKRCEILQMMMLEPEFVLMDETDSGLDIDALRIVAEGINSMRGPNFGALVITHYQRLLDYIVPDYVHVLYDGRIVKSGGKEIALELEAKGYDWVQNELAPAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPC1</accession>
    <name>A0A139SPC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000025">
        <property type="protein sequence ID" value="KXU36455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36455">
        <property type="protein sequence ID" value="KXU36455"/>
        <property type="gene ID" value="AXK12_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="454" mass="51101" checksum="A52031813B14994A" modified="2016-05-11" version="1">MSPGSAVIFCLAIASAVLVALIPYREPDGITFWVFATPHRDAYIEPIAHWNEEHPPESRFTMTMLHPNVIEHRMISGFLSGTPVADLLETHEGIYPRVYHGPLDQIGFLDITDRLHEEGLYEQYDRTTLLQHTHRGHHFGLPITAAPALLAYRSDLAEAAGISDEAIAQIETWDDYFRVMRPLMTDLDGDGRPDRYLLSLGEVSIEAIRMLVLQNDGVLFDKDGNPSFANAQNARTLATLTTWITGPKRVATDVALHTSTGHKQRLDGFVVGTIITNWMLAQWKRENPQIEGKLKFIPIPAFEPGGRRTSTSGSTMISINKHSLHIETAWEMAKNLYTSIEVAEYLYRVAGMITPLKENWDAPFYHEPDPFCGGQQTGTLFIEQIPHMPQSPVSPYQNLAYSELVNAMMALRTYAEQYSIYEVEPLAIEALRLLKKSQEALQKLVDRNVFIGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPG1</accession>
    <name>A0A139SPG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711251.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03385"/>
    <dbReference type="EnsemblBacteria" id="KXU36341">
        <property type="protein sequence ID" value="KXU36341"/>
        <property type="gene ID" value="AXK12_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="373" mass="40354" checksum="026FC81AD27BE701" modified="2016-05-11" version="1">MKILLVQDFLRSGGTERQTILLANAFAAAGHPTSLLTFRPGGPLAHTLSPAVTHRALQPFDTRLDWFAPGLRRAVRRASPDIVLCMGRMANCHGEQIANTLSRLHLRQRANECAAEIKEPTTPASLGTMRTGKPLPLLARRALGRVTHIIANSEAARTTLQTRYSVPPERISVIPNALVFPPLPHAEAAPARAALRSEHGADDTTTVLLDCAMFRPEKNQRELIEIAAQLPATLHWQLWLAGDGPALADCRARATQLGLADRVHFLGFVADPRPLYAAADLAVHASKSESLCNFLLEAQAAGLPSIAARAQGIEECLTRPGETGLVIEHGDRDGFRRAILHFAQAGFRKTPTTQTADPAAAYLALFQKLLTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ36</accession>
    <name>A0A139SQ36_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">AXK12_03120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711211.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03120"/>
    <dbReference type="EnsemblBacteria" id="KXU36624">
        <property type="protein sequence ID" value="KXU36624"/>
        <property type="gene ID" value="AXK12_03120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="116"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="157"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU36624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="393" mass="41956" checksum="054C96331ABEE8A2" modified="2016-05-11" version="1">MTRNCILPGTGRIGILGGGQLGRMLAQAAQSLGFSVAVYEPQVACPAGAVANQEVNAPYADLDALRDFVHGCDVVTYEFENIPTAPLKALEAAGLGQRLRPDWRILEIAQNRLREKTWLRDQGIPHARFASVPEGGDLAAAIREVGLPCVVKTADFGYDGKGQLKLTSEAEIAAAQAQFSGQAAVVEQWVTYQCELSVVVARGVGGELRTFPPAENIHTNHILDISILPARVPPGMMARAEALAVEIAQKLGLVGVLGVELFLTESGELLVNELAPRTHNSGHATLDACATSQFEQQVRAICGLPLGSVAPRARVAVMVNVLGDAWFPQRDSAVPQTPNWAALLADAHTKLHLYGKAEPRRGRKMGHFTVLGDDAEETLTRARALKAQLHAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ70</accession>
    <name>A0A139SQ70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711152.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36716">
        <property type="protein sequence ID" value="KXU36716"/>
        <property type="gene ID" value="AXK12_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="169"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="377" mass="40556" checksum="A0D1A218E19D66DB" modified="2016-05-11" version="1">MTQETRIGIMGCGNISKAYLELSARFRGIKIVAVADVVAAAAEARAKEFNVRALTPEALLADPELDLIVNLTVPAAHYEVTRKALEAGKHVFSEKPYVLSVEEGNKLRALAKEKGLRLGSAPDTILGGAHQYARHLVDKGEVGRITSGLCGVMSHGMESWHPNPGFFFLPGGGPMLDLGPYYVSNLVQLLGPVKRVAAFTSAATPTRVVTAEPNAGKIIPVETPTNIHATLEFAQGAVITLITSWDVWEHGMEPMALFGTEGTIHLPDPNNFGGEIQMARIADFPGKPSWEIKPTPVEQWDHPFSGEGNFRCAGLTDMAHAIAEGRPHRCNADFALHVVDIMTGILRAGDSGRVIDMQTTCERFAPLGPDEARALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ80</accession>
    <name>A0A139SQ80_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="9" type="ORF">AXK12_02795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711139.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02795"/>
    <dbReference type="EnsemblBacteria" id="KXU36703">
        <property type="protein sequence ID" value="KXU36703"/>
        <property type="gene ID" value="AXK12_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="136" mass="14728" checksum="1CEC1C65FEF7D74A" modified="2016-05-11" version="1">MSLTLEIVTPEARVYSDTVDSVVIPTVEGEIGILPGHLPLLTQVAHGELVVAQPGGGQERLAIGGGFAQISGDKVSVLAEHACSEDSIDERAVEEAMKRAQQQIEESQHLDPQQYEQLQKLVNYAGAQLSLKRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ86</accession>
    <name>A0A139SQ86_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) sector subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-type ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AXK12_02765</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711133.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02765"/>
    <dbReference type="EnsemblBacteria" id="KXU36697">
        <property type="protein sequence ID" value="KXU36697"/>
        <property type="gene ID" value="AXK12_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXU36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="70" mass="6795" checksum="B53DE721030A7BD2" modified="2016-05-11" version="1">MLPAILAEITGNLTSALGLLAAAVGVALIGTKAAESVGRNPGASGKILVQAIIGMALVEGLGILALFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQG1</accession>
    <name>A0A139SQG1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">AXK12_02785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711137.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02785"/>
    <dbReference type="EnsemblBacteria" id="KXU36701">
        <property type="protein sequence ID" value="KXU36701"/>
        <property type="gene ID" value="AXK12_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="292" mass="32399" checksum="3C5A44A6ABD2C0FC" modified="2016-05-11" version="1">MASTRDIRRRIKSVKNTRQITRAMELVAASKMKRAQQATLAGRPYALLMADMLGALASRVDGTQHPFLEKREIKTRGILLLTTNIGLCGALNANLFKLVGEVKSAAKFVAIGRKGAQYLARTKRDLIAEFVVDDRGSFNEVKVAIEFMTERFLAGEIDTIEVIYPRFKNTLVQTPLLRPVLPLSNVRDFAATLEVEAGVHSDSPTDTREMLFEPSAPEVLDALLPFYVNRFIHQLVLSARASEFSARMVAMKTAKDNASKLLDDLTLEYNKARQAAITQEILEIAAAQYVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQM5</accession>
    <name>A0A139SQM5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711186.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03090"/>
    <dbReference type="EnsemblBacteria" id="KXU36751">
        <property type="protein sequence ID" value="KXU36751"/>
        <property type="gene ID" value="AXK12_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="321" mass="33947" checksum="29C5D0842DDEF605" modified="2016-05-11" version="1">MRVPKLDWFLIGMGLAALLAWAVPGPGASGGWLRPEFTVKAGVALIFLLHGLLLSFAALRAGALSWRVHLVVQGCTFLFFPLLGLALLPLLEGVFSPELRLGIFFVCVLPSTVSSSVAMTAAAGGNVPVAVCNATLSSLIGVVLTPLGMSVVTATTGQPIPLGEVIWDLVVWMVLPLAAGQVLRPVLGSLVQRHKAKVNLADRLVILLLVYTSFCESVRRDVWTGQSPWALGGVALVALGLFFAAMAAVRLVCRWAGMPREDEIAAIFCGSKKTLAAGVPMAQLIFGATPALGLILLPIIVYHQLQLLVCSVLASRWAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQU9</accession>
    <name>A0A139SQU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711122.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02725"/>
    <dbReference type="EnsemblBacteria" id="KXU36884">
        <property type="protein sequence ID" value="KXU36884"/>
        <property type="gene ID" value="AXK12_02725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="87" mass="9178" checksum="15D663E33C5A8C8B" modified="2016-05-11" version="1">MAANQLVQARIDGAIKEEASAVLAAMGLTVSDAVRLLLTKVAQEKALPFEPLIPNATTIAAMKEARKGGLPRFTSVKALMDDLNADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR03</accession>
    <name>A0A139SR03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronate 5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000019">
        <property type="protein sequence ID" value="KXU36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711119.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02710"/>
    <dbReference type="EnsemblBacteria" id="KXU36881">
        <property type="protein sequence ID" value="KXU36881"/>
        <property type="gene ID" value="AXK12_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="352" mass="39033" checksum="D6C24A9C9618B558" modified="2016-05-11" version="1">MKVLVTGAAGFIGYHVCKRLCAHPECETLGIDNLNDYYDVSLKRARLAELEAQQAQHLRGRATAAGGLAASALGADSPGGPNFRFVQADFAEGDVLLKLWAQFRPDYVVHLGAQANVRYSVTHPEAYVQSNLVGFFKVLEAARRHPPKHTVFASSSSVYGASATIPFAEDGDTSHPLSFYGATKKANETMAHSYAHLYGLALTGLRFFNVYGPWGRPDTAPTLFAKAIYSGEPLKLFAEGRVRRDFTYIDDICDGLLKLLLYPPLEPPVPPFRLFNIGHHRPVETLLFVRMLEELIGRKAQLELLPPQAADVPETCASLDHIYAAIGYAPRVPLEDGLRHFVEWFRNYYKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SR84</accession>
    <name>A0A139SR84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711050.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02320"/>
    <dbReference type="EnsemblBacteria" id="KXU37096">
        <property type="protein sequence ID" value="KXU37096"/>
        <property type="gene ID" value="AXK12_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="112" mass="12259" checksum="85BA9873036459D9" modified="2016-05-11" version="1">MKLITAIIKPFKLEEVKQGLSEIGVEGMTVTEVKGFGRQKGHTEIYRGSEYTVDFLPKVKLEIVLCDSLVPKALDTIVAAAKTGKIGDGKVFVSPIEEVIRIRTEERGEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRD4</accession>
    <name>A0A139SRD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">AXK12_02365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="LSZP01000016">
        <property type="protein sequence ID" value="KXU37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711059.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02365"/>
    <dbReference type="EnsemblBacteria" id="KXU37011">
        <property type="protein sequence ID" value="KXU37011"/>
        <property type="gene ID" value="AXK12_02365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="161" mass="16238" checksum="594DA823C81DF1CE" modified="2016-05-11" version="1">MTKPLVGLIMGSTSDWATMQHAAAVLDSLGVAYEKRVVSAHRTPDLMVSYAKEAARRGLRVIIAGAGGAAHLPGMVAALTPLPVLGVPVESAALKGLDSLLSIVQMPGGVPVATFAIGKAGAVNAAHFAAQVLAAGGDDAVRKAVAAHREAQTATVEASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRH5</accession>
    <name>A0A139SRH5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_02165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000013">
        <property type="protein sequence ID" value="KXU37158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711026.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02165"/>
    <dbReference type="EnsemblBacteria" id="KXU37158">
        <property type="protein sequence ID" value="KXU37158"/>
        <property type="gene ID" value="AXK12_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU37158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="209" mass="24046" checksum="69CED6BE4998458E" modified="2016-05-11" version="1">MDVTLSRTLTASPERQQEADSDWGVVERVQSGEVEAFDELILRYRGRVYGMVYNMTSNREDAADLTQDAFIKAFQSINRFQGQSSFFTWLYRIAVNATLSHLRKHRLRTFFSLEKVDENDRPSAEVIEALTDHSGAERGTLVKELQERLNEAMQKLSIKHRTVVTLFEIDGLSHQEIAEIMNCSVGTVRSRLHYAKQQLQSDLQSFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRJ6</accession>
    <name>A0A139SRJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_02340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02340"/>
    <dbReference type="EnsemblBacteria" id="KXU37100">
        <property type="protein sequence ID" value="KXU37100"/>
        <property type="gene ID" value="AXK12_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039423">
        <property type="entry name" value="TonB-dep_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32552">
        <property type="entry name" value="PTHR32552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="7">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="6">
        <location>
            <begin position="261"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="729" mass="82018" checksum="46DEE827995D3DF3" modified="2016-05-11" version="1">MLGLAVTTYAQQTSAQNDEEIVRLSPFSVQESADIGRYQAVEASSGTRVRMNLMDSTQSISVVTSEFLADTGSARVLDAVKYVAGVGASTQPNALDVMNVRGFRSYGTTIDGFNQFSMLNQDPIIIDRIEVVKGPNSVLAPQGLPGGVVNNVSKKPLFTNQGYASYQVGRWDANRAEIDGNYVVNDKLAVRVVGAVTDADDYGKGEYHQNITVMPMFTYRISPKTEFTAQLQIYNGSMLANNGNPVSLYAVNRSHVRLQEGLPRDFQFIGRGITRHQSGKNTRLFLTSQITDKLSMRIAGNWAYQNYRPNFFGTGDADTEVIQLDQITGEWSWDGVTRNDNPRYQFGGINEWNKLYYGNLQNDFVYEHTADTWKSQTVTGYAINYSGQSFRRIDHEPDGIWYDFTNNFTPPSGYTLQDKWFANSKSYTRSRQFYIVEVLNFFEDRLVLSGTLSYNHYFSGSTDNLTVASTQSSTEVWVPSGGVVYKLTPGITAYYGYTKQELDGPARPTSGIPHHTVPSEQHEVGVRLKLFDGKLYTTFAYFDIVQDNLVTWNFENFRQPPPNPPAPDIMSNRTAKGFEFEFAWAPTKNFSVIGSYTKYENRDADNMRYSNVAEEMGGIWGQYTFSETGPLRGLSIGLGANYVGERPSDVIGQFTQPPPGVDPVRIQPSFWIPSYTVVEASVNYRFNKNWKAQLVVNNLLDRDYIPGSFNRYIFVSTPINPKLTVRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRR1</accession>
    <name>A0A139SRR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711013.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02120"/>
    <dbReference type="EnsemblBacteria" id="KXU37233">
        <property type="protein sequence ID" value="KXU37233"/>
        <property type="gene ID" value="AXK12_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="186"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="461" mass="49813" checksum="B9792A03C3FF1AA2" modified="2016-05-11" version="1">MFDPIEKLKAYVAHASVSADPAFAPHMAGARDFVGGLLSEIGFAVEYVPTALHPVVVAKRPARGEAAKTAPHVLIYGHYDVQPPDPLDLWETPPFEPQVRGSRIYGRGTADNKGPLMAHIAAVARLVEATPDLPLNLTFVVEGEEEIGSVNFKTFLREHRDKLAGADFIFMSDTGIPSPEQMVITVGLRGIASFEIALTNAAMDLHSGGHGGAILNPIQALAELCATLHTPDGRVNVPGFYDEVCEVEDWEREELRALDLNEADYAKFLGVSQFYTPPGYSPFEAVRFLPTLEFNGISGGYQGEGAKTVIPSVARAKVTCRLVAKQNPAAIKAQIFKTLRERAPAGLKMELLSQHDAEPYLVVPPGRSNTPADQSPRLAAGFRAVEAAVKEVWGGRPFYLREGGSVGLIADLKAELGLDAIMLGLFLPEDNLHAPNESFDLGIMQKGITTIETALRNMART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRU4</accession>
    <name>A0A139SRU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37234">
        <property type="protein sequence ID" value="KXU37234"/>
        <property type="gene ID" value="AXK12_02125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="528" mass="59343" checksum="FA5BDC908EF2BCBA" modified="2016-05-11" version="1">MRLAYLVVVAVFFSVFSSFYIPGKGFSYLVFFGSKQPAVISELGETNYYLHENSYGYDGQFYAQIAVDPTLRNPELLESVDSLSYRGRRILMSLSAYLMGWGNPGAVLHAYTLQNVICWVLLAVLLLWWFPPNSWQNWFRWTGVLLCAGMWASMMRALTDGPSLLLVAFGVFLIEKNKPWLAATVLGLSGLAKETNVLSVTPFLRHEALLTPRKWPTLILQSLLVLSPLVLWVFYIDKVLGLPPSAGLNNFTWPFGGWAWRLKFNAVDAFSQDFLTGRGLPNLSFLCLLGLLALSVQCAFFLLRPKWDKPWWRIGASFSLLMAVLGEAVWEGFPGASFRVLLPMQLAFNVLVPRTRHWIPILILGNLTLLTEIHVILDSTKQVQSIVRFEQSLPDHRRTRSSFSQKGLISVEFSSGWYIAEYSGRGKWVWSSGPSEVTLRNKLPTSETVALEFSIHSLEARDLTLRDASGAVLWHTDALKDKVRVTVEGVVLKPGTTVLRFETSQGASFVPPDTRPLAFCVTNLHVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS28</accession>
    <name>A0A139SS28_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02025"/>
    <dbReference type="EnsemblBacteria" id="KXU37399">
        <property type="protein sequence ID" value="KXU37399"/>
        <property type="gene ID" value="AXK12_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299421" evidence="1">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="30861" checksum="E6FE2F82C5A927BA" modified="2016-05-11" version="1">MRSLFVCSLLSLLLGQFAVQVRADSDGDGSHEFSEPRSLKLDYSGVRCVVFNVRENKLRVDASPHPQPVLSGYVCATSEAQLAKLTLQQERQGDRLLVSLLREEAEVKDKEQPPSDSLRSYGYMDLRVAVPLEIGVEVNVTSGDAWVTGAHSLTAKVGSGELEARRIPGAVILSVGSGEVELRDIGSLTVGSIGSGEVDVENVRGLVRVNSIGSGAFDLEGADGDVKIEAVGNGEVDLERVRGSVTVGSLGAGDLEVEDVAGDFIVKERGHGRVEWRRVGGVVEIPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS48</accession>
    <name>A0A139SS48_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM_MT_RSMB_NOP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000008">
        <property type="protein sequence ID" value="KXU37425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710939.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01740"/>
    <dbReference type="EnsemblBacteria" id="KXU37425">
        <property type="protein sequence ID" value="KXU37425"/>
        <property type="gene ID" value="AXK12_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="161"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="442" mass="48946" checksum="E2D4C2ED9DA619A1" modified="2016-05-11" version="1">MNPEENGRGGPACDRNAAPKEASGTAQPRAQNQAQIFLKLLAELRPHWRRDTALPERIQRLLASDRRFGSRDRRLYRELIYTTLRYLPLIEPLLDTEEEAGTAAAKRVAELAGDTPAVAAFREGLLGNANAAPAESPFKNPDKLYPDWFWDECPTAYAPEECAALHRRAPLWLRLQGNTEGELAHALHDTETEFAARGWTLEQSEILANALRAPTDADVTNTESFRRGLFEVQDLGSQLVLASQRIPAGGHWFDACAGAGGKTLQLAQILGPSGKVTAYDIRPEALVELRERAARARLTNIEIIDTLPSEGTYFDGVLVDAPCSGTGTWRRAPHLKWVTTHERVREHAKQQLELLKQFSNYVRPGTGSPNAKRGGKMTDEEFAKLGGRLVYATCSLCRSENEVVISGFQAECSDFLVQWASHTLMPAQHDTDGFFVCVSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS71</accession>
    <name>A0A139SS71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710979.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01985"/>
    <dbReference type="EnsemblBacteria" id="KXU37393">
        <property type="protein sequence ID" value="KXU37393"/>
        <property type="gene ID" value="AXK12_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="111" mass="11927" checksum="17D26D9F1DA9276F" modified="2016-05-11" version="1">MRLGKNPYDTAALRLLGEAASELGWVETAVFAYEAIWDLEPTRQANLLALGEALLSAQRAADALKIADTLLAENPVDSAAQALMRKASIAQTLGKGNWEEAGDFRAKLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS75</accession>
    <name>A0A139SS75_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710983.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02015"/>
    <dbReference type="EnsemblBacteria" id="KXU37397">
        <property type="protein sequence ID" value="KXU37397"/>
        <property type="gene ID" value="AXK12_02015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="112" mass="12845" checksum="BCBA09E4843515F3" modified="2016-05-11" version="1">MSNNLTKREIVLEIYKKTAFPQKQIVDTVQLTLDIIQKALAKGRNVELRNFGVLEVQVRKSRVGRNPNKPEREVVIPRRAVVKFKSGKMLKQQLKKIDLSKLKSADSESDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS83</accession>
    <name>A0A139SS83_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000009">
        <property type="protein sequence ID" value="KXU37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710961.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37374">
        <property type="protein sequence ID" value="KXU37374"/>
        <property type="gene ID" value="AXK12_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="256" mass="27042" checksum="C2452E19B6F8A437" modified="2016-05-11" version="1">MSQSYLEHYNLSGQSALVTGAGRGIGAACAQALAEAGAHVHCVDRNAERVASLVEQLHAAGYRASAHALDVRETDALDRLADTVPALDILVCNAGIAHNAPAQDLSDEDWQQVIDINLTGVFKTCRAFGRRMIEAGRGSIINLGSMSGLIVNRPQFQSHYNASKAAVHQFTKSLAVEWAAYGVRVNAVAPGYIRTAIVDMVASQDPAMLGQWVDGTPIKRLGEPEEIASVVLFLASRASSLLTGSILSADGGYTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SST9</accession>
    <name>A0A139SST9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome C oxidase Cbb3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_01595</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit, denoted as copper B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="10">Binds 2 heme groups per subunit, denoted as high- and low-spin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710906.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01595"/>
    <dbReference type="EnsemblBacteria" id="KXU37655">
        <property type="protein sequence ID" value="KXU37655"/>
        <property type="gene ID" value="AXK12_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045278">
        <property type="term" value="C:plasma membrane respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:aerobic respiration"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_c-like_dom"/>
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        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004677">
        <property type="entry name" value="Cyt_c_oxidase_cbb3_su1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_monohaem-su/FixO"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF29">
        <property type="entry name" value="PTHR10422:SF29"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="COX1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ccoN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="COX1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="100"/>
            <end position="121"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="127"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="178"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="204"/>
            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="255"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="275"/>
            <end position="295"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="367"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="458"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="520"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="584"/>
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    <feature type="domain" description="COX1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="503"/>
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        <location>
            <begin position="605"/>
            <end position="768"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
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        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>B</label>
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            <position position="258"/>
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            <label>B</label>
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        <location>
            <position position="259"/>
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        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
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            <dbReference type="ARBA" id="ARBA00001970"/>
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            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU37655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="782" mass="87164" checksum="A7704BF4A44593AB" modified="2016-05-11" version="1">MSQQKLTIEYNDKVVRQFILACVIWGAVGMLVGVFVASQLNFWRLNFNLPWLTFGRLRPLHTNAVIFAFVGNMMFAGVYYSTQRLVKARLASDFLSQLHFWGWQLIIVAAAITLPLGFTRGKEYAELIWPINIAVALIWVVFAVNFFWTLARRNERALYVAIWFYIATILTVAMLYIVNHLSIPTSLLHSYPIFGGVQDALVQWWYGHNAVAFFLTTPILGIMYYFMPKAAERPVYSYQLSIVHFWSLVFIYIWAGPHHLLNTALPGWLQTMGMTFSLMLWAPSWGGMLNGLLTLRGAWDKLRTEPVIKFFVAGITFYGMATFEGPLLSIKAVSALGHYTDWIIGHVHAGALGWNGFMAAGMIYWLIPRLWSKPLYSTSLANIHFWTGLLGILLYVAAMWSSGITQGLMLNATAEEGTLLSNPNFLDALHAIQPLMLMRVIGGGLYLVGWLLLAYNLWQTVRGAQPVNGSIDIYVEAKTPAASRDSASAAADKERIGWLPTFGNGPVILSVFLVGFASLWMMGSGIVSALGIAGSLVTLIAGYALLYSRGKDWQDWYEKLLLNALPFSVLVFISVAAGGLVQIIPTVLVSKPDNVEDRLQIPYTPLELAGRDIYVREGCYNCHSQMIRTMVPDVLRYGDYSRLGESIYDYPFQWGSKRTGPDLARVGGKYPDVWHLRHMEDPRSISAGSNMPSYPWLSTNNTDVAALPSKINVQRMLGVPYGPLSPQQIFDDVNAQAKAISKGLREAGAYVAPEKEIIALIAYLQKLGQSENVAATRTASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU1</accession>
    <name>A0A139SSU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">AXK12_01495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710891.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01495"/>
    <dbReference type="EnsemblBacteria" id="KXU37639">
        <property type="protein sequence ID" value="KXU37639"/>
        <property type="gene ID" value="AXK12_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="79" mass="8514" checksum="B3EACE730F35741B" modified="2016-05-11" version="1">MAHKKGQGTSSNGRESHSKRLGVKRFGGESVLAGNIIIRQRGTKIHPGTGIGVGRDWTLFALRDGVVKFDKAKRSVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU7</accession>
    <name>A0A139SSU7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgi</name>
        <name evidence="9" type="ORF">AXK12_01475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710888.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01475"/>
    <dbReference type="EnsemblBacteria" id="KXU37636">
        <property type="protein sequence ID" value="KXU37636"/>
        <property type="gene ID" value="AXK12_01475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="534" mass="58713" checksum="D9139AC9E1333816" modified="2016-05-11" version="1">MSSTSATWSRFKDTLYQNTELGLALDISRIPFPEDFFAKREADIQAAFAAMNALEKGAIANPDEQRMVGHYWLRAPQLAPTDEIREAITTTRAKIDRFAHDIRTGAKTAPNGNPFRHLLVIGIGGSALGPQFVDQALSQPDQAPMTLSFMDNTDPDGIEAALKEIDAQGKVATTLVVVISKSGGTVETRNAMLETAAYFRDHGLDYPRHFVAVTGEGSQLDKLAQDEAWLARFPMWDWVGGRTSELSAVGLLPAALRGLDIHDMLAGAAAMDAVTRRPVTRENPAALLALMWHYETNGRGEKDMVLLPYKDRLLLFSRYLQQLVMESLGKEFDTQGRVVNQGIAVYGNKGSTDQHAYVQQLREGVNNFFVTFIEVLKDRRNLLLKEPLEVEPGVTSGDYLQGFYLGTRDALSEKDRHSISLTIDELTPRSLGMLIALYERAVGLYASLVGINAYHQPGVEAGKKAATGVIALQRRLVAALREATAPAEGQSAETLAAKVEGSPELTFKVLEHLAANGRINKAPRTPWYDSRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSW1</accession>
    <name>A0A139SSW1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710898.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37646">
        <property type="protein sequence ID" value="KXU37646"/>
        <property type="gene ID" value="AXK12_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="125" mass="13448" checksum="827C6F7179528AE0" modified="2016-05-11" version="1">MTHTPAPAPPSLKNAPVVCEIRSTHASESGILAEIAKTCARELAQPLLVKTIQAGPSTQDPLITLQLPVEMAATQHEIWCLACRLACFCPSARVSVFVSASDLFTKNKTKAAAPRTQRRSRRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSW8</accession>
    <name>A0A139SSW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_01605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710908.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37657">
        <property type="protein sequence ID" value="KXU37657"/>
        <property type="gene ID" value="AXK12_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU37657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="98" mass="10823" checksum="7CF0396252909456" modified="2016-05-11" version="1">MAKDKEPKPDLVRSSAAQYLTTHQSAYLAVYGEVKRGHRHMEPKAPLACGGETPTAGAEFFSFVAASALGEVSAQMCYEDEDIWRRLARRGAGRQTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSX1</accession>
    <name>A0A139SSX1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ORF">AXK12_01465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710886.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01465"/>
    <dbReference type="EnsemblBacteria" id="KXU37634">
        <property type="protein sequence ID" value="KXU37634"/>
        <property type="gene ID" value="AXK12_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU37634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="249" mass="26751" checksum="46D0A565E04DA4F9" modified="2016-05-11" version="1">MSLRLPMALSEPKPNTSLTVLPGHLYVVATPIGNLHDLSPRARSILSQADLLACEDTRTTGQLLARLGLPHKTLVSYHDHNERELAPKLADELASGKSVALVSDAGTPAISDPGFRLVRAARRRALPVVPVPGPCAFAAALSASGLPSNGFLFVGFLPPKSAARIAFFEKHRDFAYTLILYESCHRIEKAVTELHDSLGPERVICVAKELTKLHESFLVGPAAQVRDALSQASLKGEFVLLIAPQGFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST40</accession>
    <name>A0A139ST40_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">AXK12_01500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710892.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01500"/>
    <dbReference type="EnsemblBacteria" id="KXU37640">
        <property type="protein sequence ID" value="KXU37640"/>
        <property type="gene ID" value="AXK12_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="104" mass="11414" checksum="204DFFD412AB3597" modified="2016-05-11" version="1">MKATIRTQGQQLTVSEGDILTVNRYPNTEAGAVVEISDVLAAGAGESFKVGTPRLEGAIVSVKILENKRGKKVIVFKKKKRKGMERKRGHRQELSVIKVEAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139ST46</accession>
    <name>A0A139ST46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710903.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37652">
        <property type="protein sequence ID" value="KXU37652"/>
        <property type="gene ID" value="AXK12_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8361" checksum="22E2E50170C786DB" modified="2016-05-11" version="1">MKHALTPLPTTENPTGEQRKPANVGRKKGFRPWLLIWLAFALQVAAWVFWVKLASKHPVQEVPLVTAQPIPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STN0</accession>
    <name>A0A139STN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-mann_mid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_01265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710846.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01265"/>
    <dbReference type="EnsemblBacteria" id="KXU37820">
        <property type="protein sequence ID" value="KXU37820"/>
        <property type="gene ID" value="AXK12_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU37820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114211" checksum="0697538CDBBDAE99" modified="2016-05-11" version="1">MSRANPFLEFVPNRTEAIMRWLRRSLWLERRALEVTATRPTPEHRAFESIQTERRSRVKVGDVWGKLYDQRWFHLEIPPAAKGRQWTLEWRDQGEATLYVDGLPHYGFDPAHRYVALPQGTREVWIEGYCCQSCIWHPDATGLSPYGSLFGGGFIQYRDDVVWDCLQELGVLFDLMMTLRSQQDPKPTPHLNGVGLQPRVNDATPIYRKLLRLLNGACSTYEREGTTALREALIAAREELKNARPILKGALTGHAHIDLVWIWPERMGEAKAVHTFATMNRLMSMYPEFRFAYSQPASYRAVERRAPQLAASVKKHIARGVWQPTGGLDVESDTLLPCGEALARSFMLGQAEFARLRGKGGASRLVWLPDVFGYSVCLPQLMRLTGIDWFFTTKLTWSSINRFPYSSFVWRGNDGSEVVAHLTQNVGYTNYTHISEISANARGHSQSHLHPEFLHPTGHGDGGGGPTEEHIERVRRLSALCDLPELEWDHPEAFFSRLEPLRDQLPVHQGECYLEYHRGVYTTHGDFKAVFRGAERALQIREAVAAATGEVPDLVGPWRRLVFTQFHDFIPGSSIAEVYAEGNAELGTLIKTQMQAVCERLAAAGAGRASSRSGEKQKSTTAQLFNPLALPWRGWIDGRWYEIAPLSSVPVTEGVVPSERRQVTASVAKSGTAKLRSDRVQARLTSDGRLAELVIDGRPVAFSAAAAGAVIYLDNPANFEAWDIDRDALDLGEPVTTPVTVTVEADSPHAAAILVRRKLGEASELVLRYEVRAGEPLLRITAEVDWHETCKLLKLHFPTEYKGRFVRFGAPYGSVLRGQQPGEPITEAQWEVPGSRWATVSLDGEREGLALITEAKYGFSASDGELTVSLLRSASITAAETNPYMHAAPPSLSRYQPPSPFSDQGHHTISLALTSYSSATPQEQHPAALADTLFTLPVAYRGAPASAGLRGVEDAPTLIPAWAMPVEKGAWVLRLHEVGGARGTARLALAEGWRARPATLDGQAQEPPLEEGLIAYSPYKIISVRIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STZ3</accession>
    <name>A0A139STZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_00690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710744.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00690"/>
    <dbReference type="EnsemblBacteria" id="KXU38057">
        <property type="protein sequence ID" value="KXU38057"/>
        <property type="gene ID" value="AXK12_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="346" mass="37638" checksum="8A2FF4467BE38B78" modified="2016-05-11" version="1">MTNVSQPPRADDRAVVLSVKDLVTTFDTDAGRLTAVDGVSFTVQRGHTLGLVGESGCGKSVTACSIMRLLPQPMGKIAGGQILFDGHDLATASPEHLLKVRGGQIGMIFQEPMTALNPVHTIGRQLSEVFLLHTTRDRREALARSAEILGKVGIPSPEIRLGEYPHQLSGGMRQRVVIAMALACKPALIIADEPTTALDVTIQAQILDLMRELQREMGMAILLITHDLGVIAEMCDDVAVMYAGRIAEAGPVEQIFATPRHPYTRGLLDSIPRLSTPRKTRLATIEGMVPALADMPQGCRYQNRCPHRIPLCANLPKEEIASDSTRVSCHRWRELAADIEQPRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU05</accession>
    <name>A0A139SU05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AXK12_00980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710793.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00980"/>
    <dbReference type="EnsemblBacteria" id="KXU37962">
        <property type="protein sequence ID" value="KXU37962"/>
        <property type="gene ID" value="AXK12_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="12">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="11">
        <location>
            <begin position="527"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXU37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="749" mass="84409" checksum="EF9ECE575BF14B9F" modified="2016-05-11" version="1">MAEPAGSSPTPPVPLGAAPSSSAADAPVEQRRSLRDYYVILRERFWIALPLALLVSLVIGYYQARQTPMYASTAIIQFERPETVVTTQTVMDATIRNELDLNTYIHQLTSNRVRTRVLESLTPEEVAIIQRPYLKSQAPGEPLPPLAAMLGLLSIDPVRNSFILRLTVGHQDPEAAAILAQRHVDQFLSYLLENISGVNDTAVDFLRERAEQLRLESEAKAQRQQEYMQRHNLISLDNSTSIVDSRLLAVNGSLTQARLRLLEVESLAKQVDDYQEAGANLLEITYIGNYNTVAPLRGQMTTLLQEQARLAERYLERHPRMIEVTNAIIITQEHLDLAVQGAIADLKTSLIEVKKTIAQLENEYAENEKEALSLRNMRVDFESLQNEAAVARANYMQILDRLNQTTTTKYLEKVPIRLLDRAQVSGRPYTPNFPKIVRMCVMMFCVVFFGTAFGLDFIDDRIKSAWDIENFLGTSLLGIVPDLASVKDEDKYTLLLKDTHPTAVEAFMGIYGAAKTHSLVDYPKSMLVTSTIPGEGKTLVSANLAASFARHGKRTLLVDCDLRRPMLHRRFDLANTSGIIAFYEADGDLDCDLPNDSTLGIVKLSENLSLLRSGGRSRRPTELLESPFFGDLLQKLGHYYDLIIIDSPPLGAVTDGLLIAERVDEVAYVCRFNRAHRKHIQLYMRALRNAKTEVLGVVLNGLTPRRVEYYSNYRYYRSYGKYTERVDRPERETKRPKKVVEEAEVSEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SU51</accession>
    <name>A0A139SU51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710802.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37971">
        <property type="protein sequence ID" value="KXU37971"/>
        <property type="gene ID" value="AXK12_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="464" mass="52423" checksum="FA665B703DC7B06A" modified="2016-05-11" version="1">MPNFIKKLTDRFFSPGALVIVSLAALSSLVVTLLPVENPEGIQFWVFYTPHRDARIEDIAEWNRLHPDKPVVMKLMSMAAIERGMLSGFLSGTPMADVFESNNGVYPKAFLGPLDQVGFLDLTDRLHDEGLYEQFNAPSFSTMTSRGRIFGLPKDVHPVLLGYHVDLVEEAGIDVSEIETWEDYFRVMRPLMVDRDGDGRPDRYLLNLSETDHEFLVLLMMQNDGVFFDENDVPIFANERNARSLATIITWLTGPDRVATPVSPLPSGFRQQLDGLVVGNILPDWLYGDWKIHYPGMAGKIRLMPLPAWEPGGRRTSAMGGSNIGINKRSPYVEECWEIAKMLYTSARGAEKIWQSTGILSPVKTLWDEPFYHEPDPFVGGQRAGTLYIEQAPYAPERPSSPYKYITYEQVSAAAIALRAYAEQNSIYAVDRLVPEALRLLKEKETMLRRLISRNVFQEGDLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUF8</accession>
    <name>A0A139SUF8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_00780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710756.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00780"/>
    <dbReference type="EnsemblBacteria" id="KXU38070">
        <property type="protein sequence ID" value="KXU38070"/>
        <property type="gene ID" value="AXK12_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU38070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="377" mass="39398" checksum="A67E487EB6D0091B" modified="2016-05-11" version="1">MSSHNSRPYFPFRTAGPFLWPLGLIGGIAGAALVLEGLPVLRHVGALALALLLGLGLRCVWRVPPTWGTGVSWAAKAFLRFGIVLLGVRLDLLLVWGAGGAILAISVSVVLCGLIGISWLGRRLGLDPVLAMLIAVDSSICGGSAVAAAAPAVGARERDVALVVPLCSLLGTALMLGYTFAQQLWPVSELHYGVMVGATLQEVAQVVAAVTPFAGTVEAGMVAKLSRVALLVPAVSVLGWLWSRRGGGVARPIVWRRTRGRGPSRTVSENSPDGVTREPRPAGKPQRPYFVVGFFAVSLANTILLHGWPEARGWVEAVDGVVLLAAVFTMAMAMAAMGLGTDFSHLRENGLRALACAVLGWAGLAALVALEIWAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHI5</accession>
    <name>A0A139SHI5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_08150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713356.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08150"/>
    <dbReference type="EnsemblBacteria" id="KXU34042">
        <property type="protein sequence ID" value="KXU34042"/>
        <property type="gene ID" value="AXK12_08150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="529" mass="55932" checksum="7B6B2E0485435C0E" modified="2016-05-11" version="1">MKILVADKVSPKGVEYLRQQPGLSVVEAYGSTPEQVLGLVGDVHAIIVRSETKITAEVIAAAPLLKVVGRAGVGVDNVDVEAATDRGVIVMNTPSGNTIATAELTFTHILCGARPVPQAAASMREGRWDRKNFSGGELFRKTLGVVGLGRIGGEVAKRAQAFGMRVIAYDPYLAPSRAKAMQVEGVSLDTLLVQSDYITVHMPLTEATHHMIDEAALAKCKHGVRLFNCARGGIIKETALIAALQSGQVAAAGLDVYEDEPLAADSPLRSLPGLTLTPHLGASTAEAQESVGIEVAEQVADVLQGGVIRNAVNMPSLDAAALKTLGPYMELGQSLGALVQQLGPKQIDSLNITYWGRVIDLDANAITRAIQRGFLRRISGEAINYVNAPVALKRLGVQSKVLKSTDEVDYTELISVEAVAPDGTVAAAKGTLVGKTGKARVVEINNREVEVEAVGKLLIIENQDQPGMIGYVGNLLGRDRVNIANMSLSRTGPGETALIVINLDSEPSAETRAELKANPAIKMAKFVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHT0</accession>
    <name>A0A139SHT0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_08215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000062">
        <property type="protein sequence ID" value="KXU34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_08215"/>
    <dbReference type="EnsemblBacteria" id="KXU34044">
        <property type="protein sequence ID" value="KXU34044"/>
        <property type="gene ID" value="AXK12_08215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="303"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="335"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="553" mass="60141" checksum="90B3862EEBE7E1A1" modified="2016-05-11" version="1">MAPFWFIYRITLELLSGGPFNMAALWPLLGWMLGLLALRWALMAASHVLAHTGAFAIQHRLRLAMARRLGEVPLSFFAGRGSGSLRRTLNDDVNSLEGFYAHMLPDAVAAATVPLAALALLFATDWRLALAALVPLPLALLAQWWFMRRGAQKMRAWSALQKRIADQVGEFVRGVHVVKSFGLDARNFGELAAAVRGAVDWVSGYALESASGWVLFVGLLTANLVVVAPLGAWLHAQASLDLPTYVLFLLVAPAVLMPLLRLTFALGEQMHRGESLGRINEVLAAPTLADSAVAQVPDGTLDIEFADLRHRYGNRLALDGVSFTARAGQVTALVGPSGSGKSTLARLVARLYEFEAGTLRVGGVDVRAWPLDALLGRLGIVFQEVVLFDGTVRDNLRMARSNASDAAVEAAARAARAHDFILALPQGYDTPLGERGARLSGGERQRLSIARALLKDAPILLLDEATASVDAENEALIQQALDELRQGRTVLMIGHRLRTVMHADHIVVLDGGRVAAQGRHDELLRDCAVYQRLWRDHEQARHWSLSAPQEVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SHZ1</accession>
    <name>A0A139SHZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713130.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07755"/>
    <dbReference type="EnsemblBacteria" id="KXU34167">
        <property type="protein sequence ID" value="KXU34167"/>
        <property type="gene ID" value="AXK12_07755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="281" mass="30931" checksum="60C4927CE417019A" modified="2016-05-11" version="1">MNLNDSTTTALKNDQHNCWPEAESVERFRANLAAVNARIAAACARVGRAPSEVRLLPVSKTKPAEVVRLAYAAGVRIFGENKPQEAHTKWEALCTELPDLRWSVIGHLQTNKAKLVARCASEFQALDSLRVAEALERRLQAEGRGLDVFVQVNTSGEANKYGLPPEEVAAFLRELPSFSALRVRGLMTLAVFSDDAERVRRCFVVLRELRERLRQDAPSRISLDELSMGMSGDFELAIEEGASVVRVGQAIFGARATPDSHYWPSGALETEKAKPSEDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI00</accession>
    <name>A0A139SI00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AXK12_07990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000061">
        <property type="protein sequence ID" value="KXU34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713214.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07990"/>
    <dbReference type="EnsemblBacteria" id="KXU34110">
        <property type="protein sequence ID" value="KXU34110"/>
        <property type="gene ID" value="AXK12_07990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXU34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="176" mass="19046" checksum="24B04FCA81AD854B" modified="2016-05-11" version="1">MATSTFSQLRAGLLTHSAEECEAAATAFARELPADTTLALHGDLGVGKTTFVRGLARGLGIREAITSPTFSLYSLYRAETAETENGITAATTLEKNGQTASTTAPLRPRPTTLLHLDAYRLDTASEVEALLLEDFLQSPWCLAIEWPEKIADWLPQNTLHLTLSIASAHTHKIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SI17</accession>
    <name>A0A139SI17_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000060">
        <property type="protein sequence ID" value="KXU34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068713140.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07790"/>
    <dbReference type="EnsemblBacteria" id="KXU34173">
        <property type="protein sequence ID" value="KXU34173"/>
        <property type="gene ID" value="AXK12_07790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="139" mass="15562" checksum="8F2301B8BE5B5DDE" modified="2016-05-11" version="1">MQKTFVIFKPDCMAQRHVGEVLARFEAAGFDVVGCKLARLSPELLREHYAHVADKPFYPEIEAFMSQRPVIMMALQGDGIVARVRDLLGPTDSTKAAKGTIRGDFGTDMMTNVVHASDSDENAKIELARFFRPDEIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIW9</accession>
    <name>A0A139SIW9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug transporter AcrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_07150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712807.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07150"/>
    <dbReference type="EnsemblBacteria" id="KXU34522">
        <property type="protein sequence ID" value="KXU34522"/>
        <property type="gene ID" value="AXK12_07150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="1125" mass="120945" checksum="E8E8397397B441AE" modified="2016-05-11" version="1">MLKRLIHFSLRNRLSVLALAALVLGYGGTVALKLPIDVFPNLNRPTVTLMTEAAGLAPEEVETLISIPLETALNGAPGVQRVRAQCGVGLSIIYVEFDWGQDIYRARQLVQERVELARPRLPLGTEVHMGPISSLMGEILLVGLTTEPLAEASSEGKRERSPASAVLTPPELRTLADWELGPRLLTLSGVSQVMVIGGGRQQLHINLDSEKMAAHGVGFEEVATAAAEAQGSSGGGFLIDGPRERLIRNLARSADPAELGAVVIRPASVESEERNESTRGRVGPARAPDASQNEWGYATASPLFIRDVADVALGTQPMRGDAGVNAAPAVILAVQKQPDADTTELTRRIERALEEMRPSLPPGVQIQVLFRQATFIENAIANVKEAIRDGSLMVILVLFVFLLNFRTTFITLTAIPLSFALSALVFQWLGVSINTMTLGGLAVAVGLVVDDAIVDVENVFRRLRENRAAPSPLPTLKVIGEASSEVRSSILYATLVIVLVFLPLFALSGIEGQFFAPIGIAIIVSMLASFLVSLTVIPALCSYLLPRMKRMRENRDAWFVRVLKAASSRWILGPSLSHPWVPMSLALVLVAASAALYPRMGKTFLPEFNEGTAIVSLIMPPGTSLEESDRMGRIGEKLLLTIPEIEHTGRRTGRAELDEHAEGVHRSEIDIEFAKSKRSRAEILGEIREKLGGLPGVVLNVGQPISHRLDHMLSGVQAAIAVKISGPDLAQLRRYAAQAKDAISNIEGLVDLQIEAQTLVPQVRVEIDRERAAHYGLRPGELSERLEAGLNGRVVSQVLDGTRSIDLVLRYADHAEMNKAETRPGELIGATRSDALGEAATPASQNKAGRRPLRSDIERLRALLIDTPLGGAIPLAQVADVHEALGPNAINREDAMRRIVISANVGGSSRRALDAIVADIQTTLAQALPMESGYFISYEGQFQSQQAAARLIGLLALLTLAAIFLLLYSHFRSAMIVAQVLLNVPLSFIGALALTYWTIGTISVATLVGLITLAGIATRNTIMMISHYLHLIQHEGEKFGPQMILRGSLERLVPVTMTALAAGLALIPLALAAHEPGKEILYPVAIVILGGLLSSTLLDMAVTPAVFLKFGKRAAAAALAQPTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SIZ7</accession>
    <name>A0A139SIZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_07190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU34529">
        <property type="protein sequence ID" value="KXU34529"/>
        <property type="gene ID" value="AXK12_07190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="74" mass="8885" checksum="852B36A6D6263454" modified="2016-05-11" version="1">MEFIKNLYGFLQIENAKFRLPSPSPILRKRLMAYRLENMEQLAFFIQETASTAIFWIRSMINIPILTNMFLRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJ17</accession>
    <name>A0A139SJ17_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">POTRA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AXK12_07300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000053">
        <property type="protein sequence ID" value="KXU34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_07300"/>
    <dbReference type="EnsemblBacteria" id="KXU34547">
        <property type="protein sequence ID" value="KXU34547"/>
        <property type="gene ID" value="AXK12_07300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="341" mass="37237" checksum="2299BC9B8B0F736F" modified="2016-05-11" version="1">MSRVARRRQWQRRLRRVGFAVGLIGLCAGVLFVAHRLAEGDLQLSRASNAEPIREVVLRTDGVLDQAWIMRRLAVPPEATLIDLDLAVLRERLLADRQVITATLTRKFPATLEVSLSERSPVARINVRSSPEEAAPRPHLVARDGVVYPGSGYDARLLAELPWLGGVRLRRVSGDSSAAQFAPIFGMPLVAELLATARNEAPALYKTWRVVSLARLESDAEIEVRTDTIDRIIFNARESAGFLRQVAQLDLLLDSVQPDAAGAISEINLAIGRMVDGRIQVPVTFKEGAGGVGGSGARSAELIAPPPPSSRRQVENGRSGTERAPNNSLFFHPTRPSAREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SJY6</accession>
    <name>A0A139SJY6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside/nucleotide kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_06485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712554.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06485"/>
    <dbReference type="EnsemblBacteria" id="KXU34879">
        <property type="protein sequence ID" value="KXU34879"/>
        <property type="gene ID" value="AXK12_06485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="207" mass="23035" checksum="F133D8B0C9217A38" modified="2016-05-11" version="1">MNSPATIVDALLQRAGDARRFLVGLAGPPAAGKSTLAEALRDGLIARGESAEILPMDGFHMDNGILAARGLLPRKGAPESFDARGFIDIVHALKRAEGEVLVPVFDRSREIAINAARAILRETRFVLAEGNYLLFKDAPWDRLDGLFDFTLFVGPPYAVLEERLRQRWLGYALPEDQIRWKLYGNDLPNGKRILENSRPADLHIDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK22</accession>
    <name>A0A139SK22_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ORF">AXK12_06640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712600.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06640"/>
    <dbReference type="EnsemblBacteria" id="KXU34905">
        <property type="protein sequence ID" value="KXU34905"/>
        <property type="gene ID" value="AXK12_06640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXU34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="393" mass="41169" checksum="33E9BEF139F8D37A" modified="2016-05-11" version="1">MNIHEYQAKALFSQFGVPVPAGVPAKSPDEFAAALAQLPEGPVMVKSQIHAGGRGKGTFTDGFQGGVKFCKTKADAAELAAKMLGNTLVTAQTGPAGRKVQTIYFTAASDIAKEYYLAILLDRASSRPVIVASTEGGVEIEKVAHETPEKITKVFVDPAYGLADFQVRELIAALGLSGTEAKNAAKLLKALYTCFWETDASMVEVNPLITTPTGEVLALDAKVSFDSNALYRHPELVALRDLNEEDPKEIEASKHDLAYIALDGNIACLVNGAGLAMSTMDIIKHYGGNPANFLDVGGGASKDKVVAAFKIILGDANVRGILVNIFGGIMDCNVIAEGIVEAVREVGLTLPLVVRLEGNNAAQGKATLATSGLALTPADSMADSAQKIVALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SK67</accession>
    <name>A0A139SK67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">AXK12_06490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000047">
        <property type="protein sequence ID" value="KXU34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712557.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_06490"/>
    <dbReference type="EnsemblBacteria" id="KXU34880">
        <property type="protein sequence ID" value="KXU34880"/>
        <property type="gene ID" value="AXK12_06490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="284" mass="29905" checksum="621A23309CA4B83A" modified="2016-05-11" version="1">MSVCDSQTKSDSSGWHARLALDFARQGPRTVLVGNRHTGPLRVQKPLHPEGEAVCHAIVLHPPAGIVGGDSLAIAVDLAAGAHALLTTPGAGKWYRSGGPSASLTQTITVGDGAVCEWLPQETLVFDGARGGQTTEIELAADARFVGVELLCFGRTASGERFAHGDFAMRTRIRRDGQTLWLERGRVTGNSPLLASPIGLAGQPVVATMWVVAPQVNEGLRDACRAILPEVGAGGVTLLPGGVLLARWLGPACEPGRAWFARLWAVLRPALSGRAAVTPRIWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKD9</accession>
    <name>A0A139SKD9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712346.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35015">
        <property type="protein sequence ID" value="KXU35015"/>
        <property type="gene ID" value="AXK12_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="465" mass="52803" checksum="36B4DA4F73F64339" modified="2016-05-11" version="1">MRNFLRSLTERFFSPGALVIFALALITTVAVTLIPASEPRGIQFWVVARQQRDSYVEKIAEWNGSHSEGPFAMTLLHDRSLEQRMLAGFLSGTPMADLLEMHEGVFPKAFLGPVDQIGFLDITERLHAEGLYEQINEPSFSQQISRGRHFGLPHDVHPVLLAYRADLVEAAGITDAQISQIETWDDYFRVMRPLMADRDGDGRPDRYLLNLSDMREDIISMLVLQNDGEIFDAQDRPIFANERNAETLARITPWLTGPERVSFDVAWFTAAGHKQILDGLVVGSMVPDWLLGLWKIENPQLAGKIKLMPLPAFERGGRRTSTRGGSMIGINKRSAHIEECWEMAKALYTSAEIAEQTWEKTMILSPVKTLWDEPFYHAPDPFVSGQRVGTLFIEQAPHVPLRPSSPYTNIAYAYLSNVAMGLRSYAEKHDCYDPEVLKPEALRLLHYYQDRLEKLISRNVFLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKF8</accession>
    <name>A0A139SKF8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000045">
        <property type="protein sequence ID" value="KXU35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712398.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00290"/>
    <dbReference type="EnsemblBacteria" id="KXU35041">
        <property type="protein sequence ID" value="KXU35041"/>
        <property type="gene ID" value="AXK12_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="289" mass="31585" checksum="220ABE56E89DDE78" modified="2016-05-11" version="1">MSTHSQTPTLSSNAASATSHELVIEAGRSERHYYLDLWRYRELLGFLAWRDIMVRYKQAALGVAWAIIQPVIQVTLLTFVFGKLAGMPDGGVPYPLIVICGTLAWQFFATAFSGAGQSLVSNTNLISKVYFPRLVIPMAALGVALVDFAITLALALPVILLLGPGIGWQLACLPLFILLGLLISLGAGLWIAALTVRFRDFRFITPFLMQVGVFVTPVGFRTDILPGWQSLLALNPLAGLVDGVRWCLLGGHTQLYLPGLGISLIVTAALLLSGLWYFRRVERQFADII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKU7</accession>
    <name>A0A139SKU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712146.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05700"/>
    <dbReference type="EnsemblBacteria" id="KXU35198">
        <property type="protein sequence ID" value="KXU35198"/>
        <property type="gene ID" value="AXK12_05700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="165"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="406" mass="44958" checksum="57EC2767EA195188" modified="2016-05-11" version="1">MKITRIDTLQIGEFPFLLWLQVHTDSGLIGTGETFWAPGPVASYIHENVASYLLGKDPRDIELHDRRLASVYVGARDSGAELRGNSAINIALWDLYSQSLGEPLWRLLGGRTHQSVPVYNTCAGYGHVRATGRNALFERTEDWSLKPGDMDEGPYEDLLAWRYDAGGLAKSLLQEGIRAMKIWPFDIAAEASNGARITLRDLDKALEPFAKIRQAVGNEMEIMVEMHGLWTLPPALRIAEALKPFSVAWLEEPIRYNEFDAMAELARHTNIPLAASERLATRQMFKQLIDKRAASIIMIDLAWCGGLSEARKIANMAEASELPVTLHDCTGPVVYAASCALSATLPNVTYQEMVRAYTTGWYREIADNIPEVADGGVSPLPGPGLGLRLKPELFSRPDAIVRTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SKW8</accession>
    <name>A0A139SKW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35203">
        <property type="protein sequence ID" value="KXU35203"/>
        <property type="gene ID" value="AXK12_05730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021279">
        <property type="entry name" value="DUF2721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11026">
        <property type="entry name" value="DUF2721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="20041" checksum="3F8B5E6A6D5A8177" modified="2016-05-11" version="1">MIAKALDFAHLLFRRKSHARFMDHLHSNSVLSIIQLAITPVILISGIGALMITLTNRMARIVDRTRNLAAQAWAASGEERKYLESQLVILWTRSKLIRRAVTFAGMTMLIACCLVIVIFITALLERDLVVLMLMLFTASILMLISALILFLRDIYLSLRVLHLEVRRALPDSEAPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL09</accession>
    <name>A0A139SL09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712251.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05965"/>
    <dbReference type="EnsemblBacteria" id="KXU35243">
        <property type="protein sequence ID" value="KXU35243"/>
        <property type="gene ID" value="AXK12_05965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="6">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="196" mass="21248" checksum="5951D92D8D462AF8" modified="2016-05-11" version="1">MTRPTSITTRSGDGGTTGLLYGQRVSKAHPQIEAVGTLDELNVAIGAAKLATRAHPPVADAANGDQSPNASNAPRMRLDAIQQTLVALMGEVACAADAVARYEKSKFEKLTDDDLDRLDAQIAELESRGLIFDGWARPGANALAIAYDQARVTARRAERRLVTLAEQHHAIRPLLLRYLNRLSDLLWLLAREAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL25</accession>
    <name>A0A139SL25_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000044">
        <property type="protein sequence ID" value="KXU35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712139.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35194">
        <property type="protein sequence ID" value="KXU35194"/>
        <property type="gene ID" value="AXK12_05680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="395" mass="40793" checksum="8266490F5E08E807" modified="2016-05-11" version="1">MPAAIWALAIAAFGIGTTEFVISGLLPGIAAEFAISIPTAGYTATSYALGVFVGAPLLVVLGLRLPQKAMLMGLLGFFIAGNLLTALAPGFAWVLAGRVLTSLTHGAFFGIGSILAADMVAPNRRTTAIALMFSGLTLANLLGVPGGTWLGQALSWRATFFAITVIGVLALSAVALWVPKRKSHEVPNLRRELAAFADAQVLLAMGITIFGPAAFFTAITYIAPMMTERAGYSDHGVSGILLLFGLGLFIGNLLGGKLADRALMPLLYITLAGQALVLFVFFFVVQSRLASALCVLLMAGFGFATVAPIQRLVLDKARAAGASSNLIASFNIGLFNLGNAIGAWLGGFVIAQGFGYAAPNWAGGLLSTLALGLALLSGWASAAAASRSSRSVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL81</accession>
    <name>A0A139SL81_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712104.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35319">
        <property type="protein sequence ID" value="KXU35319"/>
        <property type="gene ID" value="AXK12_05585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="94" mass="10792" checksum="A4EFD9A18B16FB81" modified="2016-05-11" version="1">MMIVQSLHNPILGGGILLIAVSLYLQLTLQRRLDRLETRFKDNRLNSEQLDRWTFWARWLPVIFTVLGVVLLIWGFNEALEAAEAAELQGANSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SL88</accession>
    <name>A0A139SL88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_05580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000043">
        <property type="protein sequence ID" value="KXU35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712102.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05580"/>
    <dbReference type="EnsemblBacteria" id="KXU35318">
        <property type="protein sequence ID" value="KXU35318"/>
        <property type="gene ID" value="AXK12_05580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="213" mass="24200" checksum="3131B64CBD20CC69" modified="2016-05-11" version="1">MSEILGSAWIEPVATVLGALGVWLIVRQSMWNFPVGLVQVTLSGLVFYHSRFYGEVKLQVLYFVVLSYGWIHWARGDRRRDSINELAKVVSGEKPALPVTVLGWGWRVGYVFVGAVATVVWGTYMLRHTDAAAPYRDAFITCFSVVCTWLQARKRLENWIGWIVVDTVAGVTYLMSGLYWFGVLYLFFCALAARGHFEWSRAYRQNAASRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SLM7</accession>
    <name>A0A139SLM7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AXK12_05370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000042">
        <property type="protein sequence ID" value="KXU35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068712009.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_05370"/>
    <dbReference type="EnsemblBacteria" id="KXU35400">
        <property type="protein sequence ID" value="KXU35400"/>
        <property type="gene ID" value="AXK12_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXU35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="21234" checksum="9286662E50ECAB63" modified="2016-05-11" version="1">MSLFKTRRTIKPAFMDASREVPLALLDTILEDAHWAPTHGLTQPWRFHVFHGRRKLLDLSEGLQAVFCASVPAEQQDEGTLNKLAQYPAGSAAAVALLVHVPAKSRIPEWEEVAAVCCAAQNLMLSAHTQGLGAFWSTTPTTTRPEFVHWLGAEPELHRSLGIIYLGWPKDGAREKLSSTRVPLAERIIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM51</accession>
    <name>A0A139SM51_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_04890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000036">
        <property type="protein sequence ID" value="KXU35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711828.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04890"/>
    <dbReference type="EnsemblBacteria" id="KXU35653">
        <property type="protein sequence ID" value="KXU35653"/>
        <property type="gene ID" value="AXK12_04890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="298"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="556"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="330"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="632" mass="69433" checksum="CFEC009300FF5C87" modified="2016-05-11" version="1">MLTLADVSKSYGTRELFAQVSLFVARSDRYGLVGANGAGKTTLFNLILGEEQPDTGVIEWERGADFGFLPQESAPVGEETILSIATGGAKLDLTGEDDEDYDIDWTLEPRARKILAGLGFKDADMELPANSFSGGWIMRAHMARLLVAEPALLLLDEPTNHLDLEALLWFQDYLTRYPGGLLIISHDRAFLNALCTGILELRGQTLHRYHGNYDDFLIERDARKEQQTALFKNQQREIAHLQKFVDRFGAKASLASRAKSREKQIARLKEVAIEEPDDELRRINFRFPQPPRSGLKVIELAGVEQAYGEHVVYRDLNFKAERGQKLVLVGPNGAGKSTLLKILGGVLPIRGGVRELGSNVTAGYFAQNRGENLNLGATVLENMLELRTAQNGLTEQQSRALLGAFLFRKDDVFKKASVLSGGEKSRLALARLLVDPPNLLLMDEPTTHLDIASIDALIRALRDFTGTFIFISHDVHFIRELDAHVLHVHSGRLTSYAGNYDYYLEKSRATNARAALTAGFTDGRPAQAAAPASGQQAAAHLAPARQKNGSATPNELRKRRAALGELEKRVSELETAQAELTAALEAPETYQQPGKAQHLNRELSAIVDQIAAATAEWEKAATALAELEGNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM60</accession>
    <name>A0A139SM60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000037">
        <property type="protein sequence ID" value="KXU35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711896.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35621">
        <property type="protein sequence ID" value="KXU35621"/>
        <property type="gene ID" value="AXK12_04970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="18232" checksum="B2ED78CD747B88F0" modified="2016-05-11" version="1">MSLSPDQNRAVAAWVAAGDNLSTVQKKLQDEFQVSMTYMDVRFLVDDLDLSLQDPASTADASDVSNPAPPPTMPAAATSAANADDGSDADAVPEPDALPPAAADGAGAAANVTVTLDAVTLLPGALASGTVRFSDGVTGKWMVDNYGRPGFTEISQPGYQPSPADAQAFIQELSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SM82</accession>
    <name>A0A139SM82_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">AXK12_04740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000035">
        <property type="protein sequence ID" value="KXU35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711773.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04740"/>
    <dbReference type="EnsemblBacteria" id="KXU35677">
        <property type="protein sequence ID" value="KXU35677"/>
        <property type="gene ID" value="AXK12_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXU35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="218" mass="23990" checksum="345FBA956396E7E0" modified="2016-05-11" version="1">MDLGLDPETLRKGAIFYILLISSLCVHEWAHAVTAHLLGDDTPAEEGRVTLNPIAHMDPLGSVIFPLLCIFVLPGALLFGWGKPVRINPANFAKRKRDELLTTLAGPVSNLILALLAAVVGGFLFRWEPRTVEVFFQLIGINVLLAVFNLIPLPPLDGGQVLRNLVGMREETFRAISRWSFLIILVAINIPAFRLLLMLAMSVVAAPMMRIYELLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMY5</accession>
    <name>A0A139SMY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_00110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000034">
        <property type="protein sequence ID" value="KXU35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU35852">
        <property type="protein sequence ID" value="KXU35852"/>
        <property type="gene ID" value="AXK12_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="177" mass="19942" checksum="2ADD3D12489F3FC7" modified="2016-05-11" version="1">MLSLNKSNGAIAIGGDIFINDHAKLTTWGTRQIERNSTVRLRDSTFQFADANIIKEESFHKLVVEGTSVLLFKLGFSDKRFLYLDDLSIDKGAELDVQGWVEGTHFFLVRKTSRNLEDALNKIKFKGYDPSKIHLEDYSDEYWMINGAPEPATYGAGLMLGVLGLVCYRRRSVTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SMZ6</accession>
    <name>A0A139SMZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_04640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000033">
        <property type="protein sequence ID" value="KXU35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711706.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04640"/>
    <dbReference type="EnsemblBacteria" id="KXU35973">
        <property type="protein sequence ID" value="KXU35973"/>
        <property type="gene ID" value="AXK12_04640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="166"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="349" mass="39593" checksum="2A210BF5E0152D36" modified="2016-05-11" version="1">MNLSESERQELMALQRSRTMAAGQVRRARLILLLDEGASRGAIMSKLGCDSRFITTWKTRFAAERLAGLYARHPGRAPRSDLAELEARVLEYTLKRKPEDGSTHWSSRKLAAQLGLPFMTVQRIWRKHDIRPHRLDKHMVSNDPAFETKAADVIGLYLKPPAHAAVFCVDEKTAIQALDRKDRMLPLSPGRAQSHGFEYKRNGTLSLFAALNTATGEVLGKTAARHTSAQFVAFLTDVLSSQPKGREIHVICDNVSSHKTAAVQAFLAEHTNVTMHYTPTYSSWLNQVENWFARIQRDVITRGIFTSTKDLHKKLMHYINQYNKRAQPLKWKYTAPRRRIRCDSSGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SN77</accession>
    <name>A0A139SN77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">AXK12_04080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="LSZP01000032">
        <property type="protein sequence ID" value="KXU36015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711496.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_04080"/>
    <dbReference type="EnsemblBacteria" id="KXU36015">
        <property type="protein sequence ID" value="KXU36015"/>
        <property type="gene ID" value="AXK12_04080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="298" mass="31994" checksum="357A5EE93C662741" modified="2016-05-11" version="1">MAKKTAPSLTGTLTALVTPFKKQQVAYDDLKALIEFQIKGGIDGLVAVGTTGESPTLTHEEHMQVVKATVEFARGRLPVVAGTGSNSTSEAIAFTKLAHEAGVDGMLLVAPYYNKPSQEGLFLHFSAIAEATDRPILLYSIPGRCGIEIGVGVIERLRAKYPHVRYIKEAGGSVDRVDQIKQALGSDITVLSGDDSLTLPFIAAGAEGVISVASNLYVREVCKLVSTALKGDLRGAAKEHRRLYPIFKTLFNEPNPVPIKLALHKAGIISRPDVRLPLCPPSAENRNALFRVMAALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNU9</accession>
    <name>A0A139SNU9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711330.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36238">
        <property type="protein sequence ID" value="KXU36238"/>
        <property type="gene ID" value="AXK12_03625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="151" mass="15713" checksum="7DF328DDEFEF7D57" modified="2016-05-11" version="1">MIDKKIQKLNAARAKVAALEHAIANERLKELAILPAKYGFGDVASFIKALKSAVGSAKVGRGVAAASARPAGAKRKHITPEAKAKVAELLNEGKSGSEIAARVGISLPSVQKIKKELGLVKARGSKAAQSEAAPVQQSVQEAPAQEQPAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SNY0</accession>
    <name>A0A139SNY0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ORF">AXK12_03660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711385.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03660"/>
    <dbReference type="EnsemblBacteria" id="KXU36267">
        <property type="protein sequence ID" value="KXU36267"/>
        <property type="gene ID" value="AXK12_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="101" mass="10968" checksum="DAC69D5C8BBEBBCE" modified="2016-05-11" version="1">MTVPLNTLVLLSTALFAIGFLGVLLRKNTLIIYMSLEIMLVAAILGLVAFSRFNGTMEGNVFVFFILTVAAAEVAVGLAIIVALFRKRTTIEVDELNALKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP12</accession>
    <name>A0A139SP12_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36262">
        <property type="protein sequence ID" value="KXU36262"/>
        <property type="gene ID" value="AXK12_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="135" mass="15378" checksum="8137F1221DC99EB1" modified="2016-05-11" version="1">MLVLGLALSAPLQAQESAPEEKPKTEKKAPKYPKRYDTNKDGIITEDEIAAGKAADKAKRDAKRQADLEKYDANSDGKLDKEERAIMKADRDAERETKRLEREAKKQEQAARRAEREAKRQERAAQKAERESKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP30</accession>
    <name>A0A139SP30_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AXK12_03635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000028">
        <property type="protein sequence ID" value="KXU36240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711334.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03635"/>
    <dbReference type="EnsemblBacteria" id="KXU36240">
        <property type="protein sequence ID" value="KXU36240"/>
        <property type="gene ID" value="AXK12_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXU36240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="452" mass="49838" checksum="5E170E36B93AB641" modified="2016-05-11" version="1">MKITGLALVPPPSAADLPKLTPELLASVLARYSRSNSGIGAILEKVDLANPDASIDRILKFVDYGHASIGGLTGGLAIALDGVSMWLAYKLFEIAQMADGQESSTRYIALAPTNLPEAEALGVPQDLAARWAQVMDEAFAAYETEYARLDALSVAEPERVRLPEEGTASAAAIGRMRKNYALDRARYFIPLATRTNVALVQSSRMWAATVAHLDSLPQPEARAAAGLIRGELLKQSPRLMRHSHAEASYREQAAQELATSLRLGLARLSTAPLADEVWVHIDRATPPWLAEEQPVAEALRHRANRYGYQGTVTRRMRVAFAWNNMALAELRDLNRHRTGHRYTPLIQAGFYLPAEVERGPHQRLLDAQASLTRELMERGSPAYVYSLLLGAQTPFEHSTHADKFIYEAELRTGLGAHFRYAEHLSAALREFFKQVPEARDWVAEGTAEPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP62</accession>
    <name>A0A139SP62_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711258.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03420"/>
    <dbReference type="EnsemblBacteria" id="KXU36347">
        <property type="protein sequence ID" value="KXU36347"/>
        <property type="gene ID" value="AXK12_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="411"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="542" mass="58928" checksum="9C4366E94FC94144" modified="2016-05-11" version="1">MPQSNRPLSRRHLFITHEFYPKRGGIATFVEEIAASACSIDADAADAVRGHSRCRDTCSALRNSPDARGSEKVNASGKAEPKTAVVTSKNSPDRKDTTGARSNELRATQASGVEVWAQRLPPRVAEKDFPFRVRRLPLHGTHDLRCVFALVRALFAERARLRETSIYLLEPGPILAFLWLQFFKTLRPRELCLTFHGSEILKLHRCPLRRVLTRRLIARATRVSTLTHYTRDLLFERFPEARSRFVLTPGAVADSRRDRGDGGADPFLWRAGKAGALVGDVGGASGGAKGGESESPRRLVVLTVGRLHPRKGQLHTLNALAALPPELQQRIEYWLVGSEATRGAGKRYAQRLRERAGSACCSDADAGSRPPKGVHPRARESAETQERSHATKGAGAQPLPCKETREESGLVVRFLGDVPDEALGAIYAQADIFALTSVVHGTSIEGFGLVYLEASAHGLPIVAHDIGGVAEAVSDGHTGLLVSPEKPDALRDAFARLIEDAELRARLGAAGPAWARRQTWRDSAAALIGVFADSPDSSQQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SP71</accession>
    <name>A0A139SP71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_03485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711277.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36357">
        <property type="protein sequence ID" value="KXU36357"/>
        <property type="gene ID" value="AXK12_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="134" mass="14682" checksum="999DF05EC1B718B9" modified="2016-05-11" version="1">MATATTPEHVETQARAEPVAANPSRERVQKISIDGNTLAVLGVGIALFTMAFGAFTHLSGRIDSLDTKIERGLGTLNGRIDTLDAKIERVATDLRTEIKDVHAKIDKLSAETNDRFDRLNEKITQILINQSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPA4</accession>
    <name>A0A139SPA4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_03445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03445"/>
    <dbReference type="EnsemblBacteria" id="KXU36352">
        <property type="protein sequence ID" value="KXU36352"/>
        <property type="gene ID" value="AXK12_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007299364" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU36352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="259" mass="27060" checksum="FF03AA36CA4BA649" modified="2016-05-11" version="1">MNLNPSLIKTSALALAVSASVSLFAQEVNFTIPSGDAANTAAPAAQAAPAAPTETFSNEVLAESFGWFMMARLGVAELQFTPAEAAAFTRGVSLAVAGQDMAHDLGAVGQQMDEFIAARQNAALERAKQRNIAAAAEFFAALKTRPGIVETATGLCYEIVEPGEGPKPKESDKVKINYTGMLLNGQVFDSSEQHGEPLTIGVNEAIPGWAEGIQQINQGGKIRLFIPAKLAYGDESLGGIPPASALIFEIELLEIVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPA8</accession>
    <name>A0A139SPA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_03345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000026">
        <property type="protein sequence ID" value="KXU36418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU36418">
        <property type="protein sequence ID" value="KXU36418"/>
        <property type="gene ID" value="AXK12_03345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU36418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="186" mass="20968" checksum="AB74EA5A93DCC0A6" modified="2016-05-11" version="1">MSGRSTRITLNKTKGAIAISGDIFIDSGARIALWGSKQIGRNSTVRLRDSSFQFTRASFIKEESFHKLVVEGKSLLHFDWSGSPQGKRFLYLDDLSIANGAELVVQGWREGTHFFLVRKTSSNLEDALKRIAFKEYLPGRTQLEDYNKDYWAISGTPEPATYGATFGVVGIGLVVWRKKKPHRHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPD9</accession>
    <name>A0A139SPD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">AXK12_03435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="LSZP01000027">
        <property type="protein sequence ID" value="KXU36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711265.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03435"/>
    <dbReference type="EnsemblBacteria" id="KXU36350">
        <property type="protein sequence ID" value="KXU36350"/>
        <property type="gene ID" value="AXK12_03435"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="181" mass="20340" checksum="CA3DAD523DCDA611" modified="2016-05-11" version="1">MNREDVNLYLVGFMGTGKSTVGWAVAPRIGFRCLDSDQEIERLQGCTVPEIFEREGEGAFRAMEREFIERGHPATRTVVSCGGGLVAQPGMLDELLGRGVVVCLHASLETILERTSRRQNRPLLEAEDRFARIRELYAAREPVYRRAGSLVLTDGRSLPDVVSHVIRVWRREAAEFARGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPU7</accession>
    <name>A0A139SPU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_03155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711206.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03155"/>
    <dbReference type="EnsemblBacteria" id="KXU36619">
        <property type="protein sequence ID" value="KXU36619"/>
        <property type="gene ID" value="AXK12_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="171"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="470" mass="51647" checksum="F4439D99A8020E9A" modified="2016-05-11" version="1">MKLPPDLLAALQAVRRVGRPRLVGGGVRDWLLGRPSHDYDIEVAGVDFPTLQRVLGRFGGTDLVGRSFGVIKLRIRGREYDFSLPRRESKEGAGHRGFAITPDPQLSDAEAAARRDFTINAIAYDPFADALIDPHDGQADLRRRILRHTSAAFSEDPLRVLRGFQLAARLDFALAPETATLCRKISDTFRELALERVWGEWDKWATKATKPSRGLDVLKETDWLRHFPEIAALDATPQDPQWHPEGNVFTHTQHCLDALVSLDSWQAATPALRRKFTFAVLAHDFGKPATTFAGERSGVKRILSPGHEAAGTAPTEAFLHRIGAPLEIATHVCPLVKNHLAHYSGQSTQGAFSDSAVRRLARRLAPATIEELLVIMRADHDGRPPLHDAETLARIDALGAKAHELALADAAPKPLVLGRHLIALGWQPGPAFKAVLDTAFEAQLDGQFHDEATGRAWLAEFLADQNEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SPZ7</accession>
    <name>A0A139SPZ7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8 9">Transaldolase</fullName>
            <ecNumber evidence="5 8 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tal</name>
        <name evidence="10" type="ORF">AXK12_03150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="5 8 9"/>
    <dbReference type="EMBL" id="LSZP01000021">
        <property type="protein sequence ID" value="KXU36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711205.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_03150"/>
    <dbReference type="EnsemblBacteria" id="KXU36618">
        <property type="protein sequence ID" value="KXU36618"/>
        <property type="gene ID" value="AXK12_03150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="326" mass="35304" checksum="67D708AAD7B2BD36" modified="2016-05-11" version="1">MATTQLDQLKAFTTVVADTGDFASIKQYAPQDATTNPSLILKAASMPDYAWLVEKAIADSRSSTASAATSAEGLSETIDRLLVLFGCEILKSVPGRVSTEVDARLSFDTAGTIAKARELIARYEQAGIARERILIKIASTWEGIKAAEQLEKEGIHCNLTLLFSFAQAVACAEARVQLISPFVGRILDWHKKATGRDYIGAEDPGVRSVTEIYTYYKRHGYATEVMGASFRNTGEILELAGCDLLTIAPALLAELQSSTAPLVRKLDPSAAAKAEVAKVNFDEKGFRYALNEDAMATEKTAEGIRAFAADIVKLEQMIATRWAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQ72</accession>
    <name>A0A139SQ72_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AXK12_02745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711129.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02745"/>
    <dbReference type="EnsemblBacteria" id="KXU36693">
        <property type="protein sequence ID" value="KXU36693"/>
        <property type="gene ID" value="AXK12_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXU36693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="245" mass="27699" checksum="14F6E6B31DA7A861" modified="2016-05-11" version="1">MPDTRSERILVVDDEPDVTELLCYTLNAKGFVVEALNDPNRCVDFAREFEPDLIVLDVMMPELSGIQICRMLRASASLKKVPVLFLTAKAEEADRVQGLEAGADDYVSKPFSTKELVLRVQSILRRSREGRQAEARVLEVGGLALDLGRHELRLHGELVALTATEFRLLHLLMSRRGRVQSREHLLLNVWNYETEIETRTVDTHVRRLREKLGSEADWVETVRGVGYRFSEKGPTAVLSDSSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SQA9</accession>
    <name>A0A139SQA9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="10" type="ORF">AXK12_02805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="LSZP01000020">
        <property type="protein sequence ID" value="KXU36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711140.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02805"/>
    <dbReference type="EnsemblBacteria" id="KXU36704">
        <property type="protein sequence ID" value="KXU36704"/>
        <property type="gene ID" value="AXK12_02805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023296756" description="Aspartate 1-decarboxylase beta chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023296755" description="Aspartate 1-decarboxylase alpha chain" evidence="9">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="123" mass="12993" checksum="A98C01A53FC897A9" modified="2016-05-11" version="1">MLRTFLRAKLHRATITAADPDYEGSVSIDRALCRAAGLLEFEEISVYDITNGVRFTTYVIYGEPGQVQINGAAAQLVNVGDLVIIAAYAALAPEEIAAHRVTVLQIGAGNTVTSTRTATVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SRA1</accession>
    <name>A0A139SRA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000015">
        <property type="protein sequence ID" value="KXU37088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37088">
        <property type="protein sequence ID" value="KXU37088"/>
        <property type="gene ID" value="AXK12_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013425">
        <property type="entry name" value="Autotrns_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02601">
        <property type="entry name" value="autotrns_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="568" mass="60599" checksum="DA7F0CC8662CCA80" modified="2016-05-11" version="1">MVADDDFAAESECEREDACDLEGAQADARLFWLRAPLLGEFPIEALDFAEVGARDEWETLRMQRMVLGKGNLPLWEREESEGSDLFLEARSAARFFGGGDTLHLASSTPANTASAAAIGFFCDFSELRPSGAFSFTPQFSPKRSTASNSASIGDSDTSHLAAADSLGAVIREPPRTGRASQLTSVFSIGGGAASVRSTREWRAASSGRADGQLPIERVHFEKVAQKNWGPTKNVLAVGNYLVTADRSLAAIKLDGVGDSWDREGYELGRVINLDKHTLSITGAGILSVGEKRDKIWNGTLATTRDNFEIHVTGGGAGYGGLEIAAVMVNAATGTTGLIKTGDGELILSNQTKNTFAGEVRVERGTLTLRSKDGAIASKTIFVGDGSGPAILNLKGGRDHIDPEATVTLRGGEAGEAAVLRFEKTHPSKGVSQKLSKLVIEGSSVIEFIDPFITDGKGTSPNKNALYIDELDLRGELTIRGWDKHDTQIFIKSSVQPDAELLAKIHVEGHANLRVSQTSDGYWSLEAVPIPEPAICGAIVAPGVLALAAWRRRARASESAQRGERAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SS09</accession>
    <name>A0A139SS09_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">AXK12_02110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="LSZP01000010">
        <property type="protein sequence ID" value="KXU37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068711011.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_02110"/>
    <dbReference type="EnsemblBacteria" id="KXU37231">
        <property type="protein sequence ID" value="KXU37231"/>
        <property type="gene ID" value="AXK12_02110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="543" mass="57912" checksum="2A78346337254887" modified="2016-05-11" version="1">MAAKLALLSVSDKTGLVAFARALVNEHGYTLLSTGGTAQALLQAGLPVTEVGAHTGFPEIMEGRVKTLHPKIHGGLLCRRDSEAHLAQAAANRIELIDLVVVNLYPFEETVARAGVSLEEAIENIDIGGPSMLRSAAKNHESVTVLCDPADYDAVLAALGKSGSANAASVDALRELRRKLALKVFERTARYDGAISNYLAARLGELENTKDAAGGARADASDEVPDMAALSGFPEQLTLSYQKAQTLRYGENPHQQAALYGSFHAHYEQLQGKELSYNNLLDITAATYLIGEFERPTVAILKHTNPCGVASADTLEAAWESAYATDRQAPFGGIIVVNHTLGAALAQTISEIFTEVIIAPRFSDEALAIFAKKKNLRLLIAKEGLGAESLQEIRSVVGGVLLQDRDKTIGRPSEFKVVTKREPSAEEWASMLFAWKVAKHVKSNAIVYCRGEQTLGVGAGQMARVDSSRIAVWKAGEAGLDLRGSVVASEALFPFADGLIAAAEAGATCAIQPGGSVRDEEVIAAANERGMAMVFTGIRHFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSK4</accession>
    <name>A0A139SSK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000007">
        <property type="protein sequence ID" value="KXU37514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710921.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01650"/>
    <dbReference type="EnsemblBacteria" id="KXU37514">
        <property type="protein sequence ID" value="KXU37514"/>
        <property type="gene ID" value="AXK12_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="299" mass="32530" checksum="EEA8E24BC62916B7" modified="2016-05-11" version="1">MSESQKMRFARRACAWPPRPQREEHVRLISEAELRAWIVHEDEEVVVLNKPGDVVCHPSKAGPWSSLVGAVREGLGLAQVHLVFRLDRETSGVVVIAKTPAVASRLQRAMQERRVGKVYWAILTGELRAPQTVDQALGDDLSSSVYIKTAVRADGASARTHFEPLAHSGVTVDAGRASAVSGALGQGGALGFTLARVVTETGRKHQIRAHAQWLGHSLVGDKIYGPDERCYLEFIDKGWSAELAAKLLLPRQALHCAEIDFRAAGLPQVFTAALAEDMRDFAQSHGLLPQTSTTRGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSU0</accession>
    <name>A0A139SSU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AXK12_01540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710900.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01540"/>
    <dbReference type="EnsemblBacteria" id="KXU37648">
        <property type="protein sequence ID" value="KXU37648"/>
        <property type="gene ID" value="AXK12_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXU37648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="288" mass="30871" checksum="55DC551F7F4765D3" modified="2016-05-11" version="1">MSPVTRQNLESCGLPSVTARELEGCANEGELTGSHLGCGGRRPSFWARYGVAGVIALGLHAALVVLWPEPSAQPLSHGNGGLREAFAGVGETMELSLIDDDDSLFGEVAEQSPSLQEQRPMQEDWVVAWDFDPSTFTQEVAPDVSGLLAASLAGQMDDAVSAALRAMQESLGQSGGRRGQGLSFGKSGILYAPNPPYPPAARREGREGMVELLVLVDGRGRAKRAEVSRSSGYDDFDETARNTVMTRWQFPARENELQIVRVVFTLTDKTRPSTPASRRAGPTVASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SSV2</accession>
    <name>A0A139SSV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AXK12_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CV41</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000005">
        <property type="protein sequence ID" value="KXU37649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710901.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01545"/>
    <dbReference type="EnsemblBacteria" id="KXU37649">
        <property type="protein sequence ID" value="KXU37649"/>
        <property type="gene ID" value="AXK12_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXU37649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="274" mass="29145" checksum="EBD808B708925182" modified="2016-05-11" version="1">MTKRILSTVLLWLIVGAVLWQFRTTGAVLLVSAISALTLLEFYRLLAGAGLAPFARLGAILGGLITLAPWLAQRFGLHAEHLLALAVVLFSIRILRERGADLRVEALASTLFGLLYVAFMLHYLVRILVIAPDLPARGLVLGLWFVAVAKFCDVGALLTGLAIGRHKMTPNISPKKTWEGAAGGIFTSMALGALIAWLGREVLPPNFTPLAAAALAAPIAATGILSDLVESIIKRRAALKDSGGLIPGIGGMFDLSDSLLLPAPVAYLLFTYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA1</accession>
    <name>A0A139STA1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AXK12_01210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CV41</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710835.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01210"/>
    <dbReference type="EnsemblBacteria" id="KXU37809">
        <property type="protein sequence ID" value="KXU37809"/>
        <property type="gene ID" value="AXK12_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXU37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="140" mass="13929" checksum="A3FE7EA53E0C2174" modified="2016-05-11" version="1">MSILLGILTFILILISVALVLLVLMQKAKNDGGAGAVLGGGMTESTFGADTGNVLSKTTINATIAFFVLSFLLYLGHLYQNRHSDASGGVGLPTIEAEASAAEAAVSAEAESANVLLPNLAAPAASAAEPTGEAAAGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STA6</accession>
    <name>A0A139STA6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AXK12_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LSZP01000004">
        <property type="protein sequence ID" value="KXU37806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710832.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_01185"/>
    <dbReference type="EnsemblBacteria" id="KXU37806">
        <property type="protein sequence ID" value="KXU37806"/>
        <property type="gene ID" value="AXK12_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXU37806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="402" mass="44508" checksum="70FC8535EDAEA0FD" modified="2016-05-11" version="1">MSNDTAQQRWVAAHIAGLPRSGIRDFFELVAKMKGQDVISLGVGEPDFVTPWHIREAAIYALEKGKTHYTSNLGMLELRRAISDYVAGHFGVSYRPEDQVLVTVGVSEALDLAFRAFCNPGDKVLYHSPCYVSYHPSIALVHAQGIAVPTYAKDNFALTAEALRAAWEPGCKILMLNLPCNPTGGTCTRDQLSEIAEFAREKDLLVFSDEIYSELTFEGQHTSIASLPGMAERTVFLHGFSKAFAMTGWRIGYACGPEALIDAMMKVHQYSMMCVSIVSQEAAIEALTHGWDSVQAMREQYHRRRDLLVRRFNEMGLKCHSPRGSFYTFPDITATGLDERTFAAELLKQEKVAVVPGTAFGEGGRGHVRACFATAYDQIIEACDRMERFVAAQLGKSDTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139STS5</accession>
    <name>A0A139STS5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AXK12_01060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CV41</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000003">
        <property type="protein sequence ID" value="KXU37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXU37976">
        <property type="protein sequence ID" value="KXU37976"/>
        <property type="gene ID" value="AXK12_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXU37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="191" mass="19893" checksum="9DB05B54B39601E1" modified="2016-05-11" version="1">MPVVLISSLALLGFGGFFGVVEVATTAFAKALGVPGKIFYPLSLCAVGSFIGGILYGRRAWGLPLRRQFLVVTGVFFASTLLFFFVGGLWGLALFCFLSGGMSAPTIIISMGLIESLVAKPRLTESMTWGLVSPLVGMALGAAVAGPVVDWAGPARAFYGVSAFGALTFAVAWVGQAWLAPPSPQGIRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A139SUC6</accession>
    <name>A0A139SUC6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AXK12_00650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cephaloticoccus capnophilus</name>
        <dbReference type="NCBI Taxonomy" id="1548208"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Verrucomicrobia</taxon>
            <taxon>Opitutae</taxon>
            <taxon>Opitutales</taxon>
            <taxon>Opitutaceae</taxon>
            <taxon>Cephaloticoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Wen L."/>
                <person name="He K."/>
                <person name="Yang H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CV41</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LSZP01000002">
        <property type="protein sequence ID" value="KXU38051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_068710738.1">
        <property type="nucleotide sequence ID" value="NZ_LSZP01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1548208.AXK12_00650"/>
    <dbReference type="EnsemblBacteria" id="KXU38051">
        <property type="protein sequence ID" value="KXU38051"/>
        <property type="gene ID" value="AXK12_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000071392">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="17"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="431"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXU38051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000071392"/>
        </source>
    </evidence>
    <sequence length="541" mass="58373" checksum="71764A1055F20AA0" modified="2016-05-11" version="1">MKRHEAITALTNTKGWDVIVIGGGASGLGAALDATTRGFRTLLLEAHDFAKGTSSRSTKLVHGGVRYLAQGNIGLVREALYERGLLARNAAHLFVNQSFIVPNYRWWEGPYYRLGFSIYDALDGRLSLGRSRYLSAGKTLSRLPTVNKSGLKGAVVYQDGQFDDARLAVNLAQTITEQGGVALNHMRVVDLIRDEGTGRLCGVIARDELGELGAHSGAARAAGQMHTLRAKVIVNATGVFTNEILAMSDPAKGRLVVPSQGAHLVLDHSFLASRDALMIPKTPDGRVLFVIPWHGCALIGTTDTRVAEVSEEPRALESEIEFLLNTAGAYLAKKPTRRDVRCVFAGLRPLAAPKDGEKRTKEISRSHKILVSEAGLVSLIGGKWTTYRRMAEEVIDKAIEVGGLPQAACKTRSLAIHGSVAPAPAKPLDRASPLSHYGSDGVAIRALQAAAPELSTRLHPAHPFTLAEVVWAIRDEMAETIEDVLARRVGLLWRDARAAIEAAPRVAEVFVSERAWTAARAESQIAAFTALAKGYLLDPEM</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>